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PMC:340383 / 16623-17880 JSONTXT 5 Projects

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Id Subject Object Predicate Lexical cue
T4051 0-3 PRP$ denotes Our
T4053 4-12 JJ denotes previous
T4052 13-17 NN denotes work
T4055 18-21 VBZ denotes has
T4054 22-31 VBN denotes described
T4056 32-37 JJ denotes human
T4058 38-42 NN denotes ACDP
T4057 43-48 NNS denotes genes
T4059 49-50 -LRB- denotes [
T4060 50-51 CD denotes 1
T4061 51-52 -RRB- denotes ]
T4062 52-53 . denotes .
T4063 53-321 sentence denotes The new information of the current work includes: 1). It is the first time to report the existence of multiple Acdp genes in other mammals in addition to human, while Acdp appears to be a single copy gene in lower organisms such as in C. elegans, yeasts and bacteria.
T4064 54-57 DT denotes The
T4066 58-61 JJ denotes new
T4065 62-73 NN denotes information
T4068 74-76 IN denotes of
T4069 77-80 DT denotes the
T4071 81-88 JJ denotes current
T4070 89-93 NN denotes work
T4067 94-102 VBZ denotes includes
T4073 102-104 : denotes :
T4074 104-105 LS denotes 1
T4075 105-106 -RRB- denotes )
T4076 106-107 , denotes .
T4077 108-110 PRP denotes It
T4072 111-113 VBZ denotes is
T4078 114-117 DT denotes the
T4080 118-123 JJ denotes first
T4079 124-128 NN denotes time
T4081 129-131 TO denotes to
T4082 132-138 VB denotes report
T4083 139-142 DT denotes the
T4084 143-152 NN denotes existence
T4085 153-155 IN denotes of
T4086 156-164 JJ denotes multiple
T4088 165-169 NN denotes Acdp
T4087 170-175 NNS denotes genes
T4089 176-178 IN denotes in
T4090 179-184 JJ denotes other
T4091 185-192 NNS denotes mammals
T4092 193-195 IN denotes in
T4093 196-204 NN denotes addition
T4094 205-207 IN denotes to
T4095 208-213 NN denotes human
T4096 213-215 , denotes ,
T4097 215-220 IN denotes while
T4099 221-225 NN denotes Acdp
T4098 226-233 VBZ denotes appears
T4100 234-236 TO denotes to
T4101 237-239 VB denotes be
T4102 240-241 DT denotes a
T4104 242-248 JJ denotes single
T4105 249-253 NN denotes copy
T4103 254-258 NN denotes gene
T4106 259-261 IN denotes in
T4107 262-267 JJR denotes lower
T4108 268-277 NNS denotes organisms
T4109 278-282 JJ denotes such
T4110 283-285 IN denotes as
T4111 286-288 IN denotes in
T4112 289-291 NNP denotes C.
T4113 292-299 NNP denotes elegans
T4114 299-301 , denotes ,
T4115 301-307 NNS denotes yeasts
T4116 308-311 CC denotes and
T4117 312-320 NNS denotes bacteria
T4118 320-321 . denotes .
T4119 321-949 sentence denotes We have also suggested the evolutionary relationships of Acdp genes in different species (phylogenetic tree); 2). Molecular cloning and characterization of murine Acdp gene family are essential for study of this novel gene family in animal model, e.g. for generation of knockout or transgenic models; 3). We have demonstrated both DNA and amino acid conservations between mouse and human for each Acdp gene and the whole Acdp gene family, which provide important information for the possibility of functional redundancy or overlap between Acdp members; 4). We have generated antibodies specific for Acdp1 and all Acdp proteins.
T4120 322-324 PRP denotes We
T4122 325-329 VBP denotes have
T4123 330-334 RB denotes also
T4121 335-344 VBN denotes suggested
T4125 345-348 DT denotes the
T4127 349-361 JJ denotes evolutionary
T4126 362-375 NNS denotes relationships
T4128 376-378 IN denotes of
T4129 379-383 NN denotes Acdp
T4130 384-389 NNS denotes genes
T4131 390-392 IN denotes in
T4132 393-402 JJ denotes different
T4133 403-410 NNS denotes species
T4134 411-412 -LRB- denotes (
T4136 412-424 JJ denotes phylogenetic
T4135 425-429 NN denotes tree
T4137 429-430 -RRB- denotes )
T4138 430-431 : denotes ;
T4139 432-433 LS denotes 2
T4141 433-434 -RRB- denotes )
T4142 434-435 , denotes .
T4143 436-445 JJ denotes Molecular
T4144 446-453 NN denotes cloning
T4145 454-457 CC denotes and
T4146 458-474 NN denotes characterization
T4147 475-477 IN denotes of
T4148 478-484 JJ denotes murine
T4150 485-489 NN denotes Acdp
T4151 490-494 NN denotes gene
T4149 495-501 NN denotes family
T4140 502-505 VBP denotes are
T4152 506-515 JJ denotes essential
T4153 516-519 IN denotes for
T4154 520-525 NN denotes study
T4155 526-528 IN denotes of
T4156 529-533 DT denotes this
T4158 534-539 JJ denotes novel
T4159 540-544 NN denotes gene
T4157 545-551 NN denotes family
T4160 552-554 IN denotes in
T4161 555-561 NN denotes animal
T4162 562-567 NN denotes model
T4163 567-569 , denotes ,
T4164 569-573 FW denotes e.g.
T4165 574-577 IN denotes for
T4166 578-588 NN denotes generation
T4167 589-591 IN denotes of
T4168 592-600 NN denotes knockout
T4170 601-603 CC denotes or
T4171 604-614 JJ denotes transgenic
T4169 615-621 NNS denotes models
T4172 621-622 : denotes ;
T4173 623-624 LS denotes 3
T4175 624-625 -RRB- denotes )
T4176 625-626 , denotes .
T4177 627-629 PRP denotes We
T4178 630-634 VBP denotes have
T4174 635-647 VBN denotes demonstrated
T4179 648-652 CC denotes both
T4180 653-656 NN denotes DNA
T4182 657-660 CC denotes and
T4183 661-666 NN denotes amino
T4184 667-671 NN denotes acid
T4181 672-685 NNS denotes conservations
T4185 686-693 IN denotes between
T4186 694-699 NN denotes mouse
T4187 700-703 CC denotes and
T4188 704-709 NN denotes human
T4189 710-713 IN denotes for
T4190 714-718 DT denotes each
T4192 719-723 NN denotes Acdp
T4191 724-728 NN denotes gene
T4193 729-732 CC denotes and
T4194 733-736 DT denotes the
T4196 737-742 JJ denotes whole
T4197 743-747 NN denotes Acdp
T4198 748-752 NN denotes gene
T4195 753-759 NN denotes family
T4199 759-761 , denotes ,
T4200 761-766 WDT denotes which
T4201 767-774 VBP denotes provide
T4202 775-784 JJ denotes important
T4203 785-796 NN denotes information
T4204 797-800 IN denotes for
T4205 801-804 DT denotes the
T4206 805-816 NN denotes possibility
T4207 817-819 IN denotes of
T4208 820-830 JJ denotes functional
T4209 831-841 NN denotes redundancy
T4210 842-844 CC denotes or
T4211 845-852 NN denotes overlap
T4212 853-860 IN denotes between
T4213 861-865 NN denotes Acdp
T4214 866-873 NNS denotes members
T4215 873-874 : denotes ;
T4216 875-876 LS denotes 4
T4217 876-877 -RRB- denotes )
T4218 877-878 , denotes .
T4219 879-881 PRP denotes We
T4220 882-886 VBP denotes have
T4124 887-896 VBN denotes generated
T4221 897-907 NNS denotes antibodies
T4222 908-916 JJ denotes specific
T4223 917-920 IN denotes for
T4224 921-926 NN denotes Acdp1
T4225 927-930 CC denotes and
T4226 931-934 DT denotes all
T4228 935-939 NN denotes Acdp
T4227 940-948 NN denotes proteins
T4229 948-949 . denotes .
T4230 949-1020 sentence denotes The Acdp1 C-terminus antibody appears to specifically recognize Acdp1.
T4231 950-953 DT denotes The
T4233 954-959 NN denotes Acdp1
T4234 960-961 NN denotes C
T4236 961-962 HYPH denotes -
T4235 962-970 NN denotes terminus
T4232 971-979 NN denotes antibody
T4237 980-987 VBZ denotes appears
T4238 988-990 TO denotes to
T4240 991-1003 RB denotes specifically
T4239 1004-1013 VB denotes recognize
T4241 1014-1019 NN denotes Acdp1
T4242 1019-1020 . denotes .
T4243 1020-1147 sentence denotes Using this antibody, we have demonstrated that Acdp1 is predominantly localized on the plasma membrane in hippocampus neurons.
T4244 1021-1026 VBG denotes Using
T4246 1027-1031 DT denotes this
T4247 1032-1040 NN denotes antibody
T4248 1040-1042 , denotes ,
T4249 1042-1044 PRP denotes we
T4250 1045-1049 VBP denotes have
T4245 1050-1062 VBN denotes demonstrated
T4251 1063-1067 IN denotes that
T4253 1068-1073 NN denotes Acdp1
T4254 1074-1076 VBZ denotes is
T4255 1077-1090 RB denotes predominantly
T4252 1091-1100 VBN denotes localized
T4256 1101-1103 IN denotes on
T4257 1104-1107 DT denotes the
T4259 1108-1114 NN denotes plasma
T4258 1115-1123 NN denotes membrane
T4260 1124-1126 IN denotes in
T4261 1127-1138 NN denotes hippocampus
T4262 1139-1146 NNS denotes neurons
T4263 1146-1147 . denotes .
T4264 1147-1257 sentence denotes These results represent an important step towards the characterization of functions for the Acdp gene family.
T4265 1148-1153 DT denotes These
T4266 1154-1161 NNS denotes results
T4267 1162-1171 VBP denotes represent
T4268 1172-1174 DT denotes an
T4270 1175-1184 JJ denotes important
T4269 1185-1189 NN denotes step
T4271 1190-1197 IN denotes towards
T4272 1198-1201 DT denotes the
T4273 1202-1218 NN denotes characterization
T4274 1219-1221 IN denotes of
T4275 1222-1231 NNS denotes functions
T4276 1232-1235 IN denotes for
T4277 1236-1239 DT denotes the
T4279 1240-1244 NN denotes Acdp
T4280 1245-1249 NN denotes gene
T4278 1250-1256 NN denotes family
T4281 1256-1257 . denotes .
R2353 T4051 T4052 poss Our,work
R2354 T4052 T4054 nsubj work,described
R2355 T4053 T4052 amod previous,work
R2356 T4055 T4054 aux has,described
R2357 T4056 T4057 amod human,genes
R2358 T4057 T4054 dobj genes,described
R2359 T4058 T4057 compound ACDP,genes
R2360 T4059 T4060 punct [,1
R2361 T4060 T4054 parataxis 1,described
R2362 T4061 T4060 punct ],1
R2363 T4062 T4054 punct .,described
R2364 T4064 T4065 det The,information
R2365 T4065 T4067 nsubj information,includes
R2366 T4066 T4065 amod new,information
R2367 T4067 T4072 ccomp includes,is
R2368 T4068 T4065 prep of,information
R2369 T4069 T4070 det the,work
R2370 T4070 T4068 pobj work,of
R2371 T4071 T4070 amod current,work
R2372 T4073 T4067 punct : ,includes
R2373 T4074 T4072 meta 1,is
R2374 T4075 T4074 punct ),1
R2375 T4076 T4074 punct .,1
R2376 T4077 T4072 nsubj It,is
R2377 T4078 T4079 det the,time
R2378 T4079 T4072 attr time,is
R2379 T4080 T4079 amod first,time
R2380 T4081 T4082 aux to,report
R2381 T4082 T4079 advcl report,time
R2382 T4083 T4084 det the,existence
R2383 T4084 T4082 dobj existence,report
R2384 T4085 T4084 prep of,existence
R2385 T4086 T4087 amod multiple,genes
R2386 T4087 T4085 pobj genes,of
R2387 T4088 T4087 compound Acdp,genes
R2388 T4089 T4082 prep in,report
R2389 T4090 T4091 amod other,mammals
R2390 T4091 T4089 pobj mammals,in
R2391 T4092 T4091 prep in,mammals
R2392 T4093 T4092 pobj addition,in
R2393 T4094 T4093 prep to,addition
R2394 T4095 T4094 pobj human,to
R2395 T4096 T4072 punct ", ",is
R2396 T4097 T4098 mark while,appears
R2397 T4098 T4072 advcl appears,is
R2398 T4099 T4098 nsubj Acdp,appears
R2399 T4100 T4101 aux to,be
R2400 T4101 T4098 xcomp be,appears
R2401 T4102 T4103 det a,gene
R2402 T4103 T4101 attr gene,be
R2403 T4104 T4103 amod single,gene
R2404 T4105 T4103 compound copy,gene
R2405 T4106 T4103 prep in,gene
R2406 T4107 T4108 amod lower,organisms
R2407 T4108 T4106 pobj organisms,in
R2408 T4109 T4110 amod such,as
R2409 T4110 T4101 prep as,be
R2410 T4111 T4110 prep in,as
R2411 T4112 T4113 compound C.,elegans
R2412 T4113 T4111 pobj elegans,in
R2413 T4114 T4113 punct ", ",elegans
R2414 T4115 T4113 conj yeasts,elegans
R2415 T4116 T4115 cc and,yeasts
R2416 T4117 T4115 conj bacteria,yeasts
R2417 T4118 T4072 punct .,is
R2418 T4120 T4121 nsubj We,suggested
R2419 T4121 T4124 ccomp suggested,generated
R2420 T4122 T4121 aux have,suggested
R2421 T4123 T4121 advmod also,suggested
R2422 T4125 T4126 det the,relationships
R2423 T4126 T4121 dobj relationships,suggested
R2424 T4127 T4126 amod evolutionary,relationships
R2425 T4128 T4126 prep of,relationships
R2426 T4129 T4130 compound Acdp,genes
R2427 T4130 T4128 pobj genes,of
R2428 T4131 T4130 prep in,genes
R2429 T4132 T4133 amod different,species
R2430 T4133 T4131 pobj species,in
R2431 T4134 T4135 punct (,tree
R2432 T4135 T4121 parataxis tree,suggested
R2433 T4136 T4135 amod phylogenetic,tree
R2434 T4137 T4135 punct ),tree
R2435 T4138 T4124 punct ;,generated
R2436 T4139 T4140 meta 2,are
R2437 T4140 T4124 ccomp are,generated
R2438 T4141 T4139 punct ),2
R2439 T4142 T4139 punct .,2
R2440 T4143 T4144 amod Molecular,cloning
R2441 T4144 T4140 nsubj cloning,are
R2442 T4145 T4144 cc and,cloning
R2443 T4146 T4144 conj characterization,cloning
R2444 T4147 T4144 prep of,cloning
R2445 T4148 T4149 amod murine,family
R2446 T4149 T4147 pobj family,of
R2447 T4150 T4149 compound Acdp,family
R2448 T4151 T4149 compound gene,family
R2449 T4152 T4140 acomp essential,are
R2450 T4153 T4140 prep for,are
R2451 T4154 T4153 pobj study,for
R2452 T4155 T4154 prep of,study
R2453 T4156 T4157 det this,family
R2454 T4157 T4155 pobj family,of
R2455 T4158 T4157 amod novel,family
R2456 T4159 T4157 compound gene,family
R2457 T4160 T4154 prep in,study
R2458 T4161 T4162 compound animal,model
R2459 T4162 T4160 pobj model,in
R2460 T4163 T4153 punct ", ",for
R2461 T4164 T4165 advmod e.g.,for
R2462 T4165 T4153 prep for,for
R2463 T4166 T4165 pobj generation,for
R2464 T4167 T4166 prep of,generation
R2465 T4168 T4169 nmod knockout,models
R2466 T4169 T4167 pobj models,of
R2467 T4170 T4168 cc or,knockout
R2468 T4171 T4168 conj transgenic,knockout
R2469 T4172 T4124 punct ;,generated
R2470 T4173 T4174 meta 3,demonstrated
R2471 T4174 T4124 ccomp demonstrated,generated
R2472 T4175 T4173 punct ),3
R2473 T4176 T4173 punct .,3
R2474 T4177 T4174 nsubj We,demonstrated
R2475 T4178 T4174 aux have,demonstrated
R2476 T4179 T4180 preconj both,DNA
R2477 T4180 T4181 nmod DNA,conservations
R2478 T4181 T4174 dobj conservations,demonstrated
R2479 T4182 T4180 cc and,DNA
R2480 T4183 T4184 compound amino,acid
R2481 T4184 T4180 conj acid,DNA
R2482 T4185 T4181 prep between,conservations
R2483 T4186 T4185 pobj mouse,between
R2484 T4187 T4186 cc and,mouse
R2485 T4188 T4186 conj human,mouse
R2486 T4189 T4174 prep for,demonstrated
R2487 T4190 T4191 det each,gene
R2488 T4191 T4189 pobj gene,for
R2489 T4192 T4191 compound Acdp,gene
R2490 T4193 T4191 cc and,gene
R2491 T4194 T4195 det the,family
R2492 T4195 T4191 conj family,gene
R2493 T4196 T4195 amod whole,family
R2494 T4197 T4195 compound Acdp,family
R2495 T4198 T4195 compound gene,family
R2496 T4199 T4191 punct ", ",gene
R2497 T4200 T4201 dep which,provide
R2498 T4201 T4191 relcl provide,gene
R2499 T4202 T4203 amod important,information
R2500 T4203 T4201 dobj information,provide
R2501 T4204 T4203 prep for,information
R2502 T4205 T4206 det the,possibility
R2503 T4206 T4204 pobj possibility,for
R2504 T4207 T4206 prep of,possibility
R2505 T4208 T4209 amod functional,redundancy
R2506 T4209 T4207 pobj redundancy,of
R2507 T4210 T4209 cc or,redundancy
R2508 T4211 T4209 conj overlap,redundancy
R2509 T4212 T4209 prep between,redundancy
R2510 T4213 T4214 compound Acdp,members
R2511 T4214 T4212 pobj members,between
R2512 T4215 T4124 punct ;,generated
R2513 T4216 T4124 meta 4,generated
R2514 T4217 T4216 punct ),4
R2515 T4218 T4216 punct .,4
R2516 T4219 T4124 nsubj We,generated
R2517 T4220 T4124 aux have,generated
R2518 T4221 T4124 dobj antibodies,generated
R2519 T4222 T4221 amod specific,antibodies
R2520 T4223 T4222 prep for,specific
R2521 T4224 T4223 pobj Acdp1,for
R2522 T4225 T4224 cc and,Acdp1
R2523 T4226 T4227 det all,proteins
R2524 T4227 T4224 conj proteins,Acdp1
R2525 T4228 T4227 compound Acdp,proteins
R2526 T4229 T4124 punct .,generated
R2527 T4231 T4232 det The,antibody
R2528 T4232 T4237 nsubj antibody,appears
R2529 T4233 T4232 compound Acdp1,antibody
R2530 T4234 T4235 compound C,terminus
R2531 T4235 T4232 compound terminus,antibody
R2532 T4236 T4235 punct -,terminus
R2533 T4238 T4239 aux to,recognize
R2534 T4239 T4237 xcomp recognize,appears
R2535 T4240 T4239 advmod specifically,recognize
R2536 T4241 T4239 dobj Acdp1,recognize
R2537 T4242 T4237 punct .,appears
R2538 T4244 T4245 advcl Using,demonstrated
R2539 T4246 T4247 det this,antibody
R2540 T4247 T4244 dobj antibody,Using
R2541 T4248 T4245 punct ", ",demonstrated
R2542 T4249 T4245 nsubj we,demonstrated
R2543 T4250 T4245 aux have,demonstrated
R2544 T4251 T4252 mark that,localized
R2545 T4252 T4245 ccomp localized,demonstrated
R2546 T4253 T4252 nsubjpass Acdp1,localized
R2547 T4254 T4252 auxpass is,localized
R2548 T4255 T4252 advmod predominantly,localized
R2549 T4256 T4252 prep on,localized
R2550 T4257 T4258 det the,membrane
R2551 T4258 T4256 pobj membrane,on
R2552 T4259 T4258 compound plasma,membrane
R2553 T4260 T4252 prep in,localized
R2554 T4261 T4262 compound hippocampus,neurons
R2555 T4262 T4260 pobj neurons,in
R2556 T4263 T4245 punct .,demonstrated
R2557 T4265 T4266 det These,results
R2558 T4266 T4267 nsubj results,represent
R2559 T4268 T4269 det an,step
R2560 T4269 T4267 dobj step,represent
R2561 T4270 T4269 amod important,step
R2562 T4271 T4269 prep towards,step
R2563 T4272 T4273 det the,characterization
R2564 T4273 T4271 pobj characterization,towards
R2565 T4274 T4273 prep of,characterization
R2566 T4275 T4274 pobj functions,of
R2567 T4276 T4273 prep for,characterization
R2568 T4277 T4278 det the,family
R2569 T4278 T4276 pobj family,for
R2570 T4279 T4278 compound Acdp,family
R2571 T4280 T4278 compound gene,family
R2572 T4281 T4267 punct .,represent