LitCovid-sentences  

PMC:7712180 / 106571-112573 JSONTXT 3 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T583 0-98 Sentence denotes Table 1 Host range, viral receptor-binding glycoproteins and host receptors of influenza viruses.
T584 99-226 Sentence denotes Family Genus Genome Type Host IAV Subtype or IBV1/ICV/IDV Lineage Disease Receptor-binding Protein Host Receptor Ref.
T585 227-570 Sentence denotes Birds Wild birds (frequently found in waterfowls and shorebirds) H1–H16 and N1–N9HP: H5NX, X = NA subtypes No or mild diseaseHP: isolated from dead wild birds HA TerminalNeu5Acα2,3GalSome gull/tern H16: α2,6Neu5Ac ≥ α2,3Neu5AcInternalDuck type: non-fucosylate, SiaLec, 3′SLNGull type: fucosylated, SiaLex and 6-sulfo-SiaLex Gull/tern H16:
T586 571-633 Sentence denotes 6′SLDN ≥ LSTb, but some 6-sulfo-SiaLex > 6′SLDN, LSTb [23,24]
T587 634-786 Sentence denotes Domestic birds (poultry) H1–H13, N1–N9 LP: mild disease HP: multi-organ systemic disease HA TerminalNeu5Acα2,3GalInternalHP higher affinity than LP:
T588 787-814 Sentence denotes 3′SLN, SiaLecAll LP and HP:
T589 815-873 Sentence denotes 3′SLN > SiaLex, SiaLec > SiaLea, 3′SLN ~ SiaLecH5 poultry:
T590 874-909 Sentence denotes 6-sulfo-3′SLNH7H7 from all species:
T591 910-1000 Sentence denotes 6-sulfo-3′SLN, 6-sulfo-SiaLex > nonsulfated SGPs [25,26,27,28,29,30,31,32,33,34,35,36,37]
T592 1001-1067 Sentence denotes Domestic ducks HP: H5N1, H5N2, H5N3, H5N5, H5N6, H5N8, H7N2, H7N9
T593 1068-1157 Sentence denotes Other poultry HP: H5N1, H5N2, H5N3, H5N6, H5N8, H5N9, H7N1, H7N2, H7N3, H7N4, H7N7, H7N9
T594 1158-1332 Sentence denotes Alphainfluenzavirus Other animals Pigs H1N1, H1N2, H2N3, H3N1, H3N2, HPH5N1 Respiratory disease HA Neu5Acα2,6Gal > Neu5Acα2,3GalNeu5AcGM3, Neu5GcGM3 [4][38,39,40,41]
T595 1333-1441 Sentence denotes Horses H7N7, H3N8 Respiratory disease HA Mainly Neu5Gcα2,3Gal, Sialyllacto-N-tetraose a, SiaLex [42,43]
T596 1442-1548 Sentence denotes 8 (−)ssRNA segments Dogs H3N8, H3N2, H3N1, H5N2, HPAI H5N1, H1N1 Respiratory disease HA Canine H3N8:
T597 1549-1601 Sentence denotes 6-sulfo-3′SLN and Neu5Acα2,3Galβ- [38][43,44,45,46]
T598 1602-1665 Sentence denotes Cats H7N2, H3N2, HPH5N1 Respiratory disease HA Feline H7N2:
T599 1666-1689 Sentence denotes Siaα2,3Gal [38,47][48]
T600 1690-1858 Sentence denotes A Ferrets(a model for human infection and transmission) Triple reassortant H1N1 SIV, A(H1N1)pdm09 Respiratory disease HA Expected to bind to Neu5Acα2,6Gal [49,50]
T601 1859-2041 Sentence denotes Occasionally in numerous species of mammals such as whales, seals, tigers, and minks Seal H7N7 & whale H13N9Tiger HPH5N1 Mink H9N2 Respiratory disease HA Seal H7N7 & whale H13N9:
T602 2042-2209 Sentence denotes Siaα2,3GalTiger HPH5N1 HA with Q226 and G228 (H3 numbering): predicted to prefer Siaα2,3GalMink H9N2 HA with 226L: increased binding to Siaα2,6Gal [51,52,53,54,55,56]
T603 2210-2616 Sentence denotes Orthomyxoviridae Zoonosis Poultry, pigs and other animals H1, H2, H3, H5 (HP & LP), H6, H7 (HP & LP), H9, H10 HP: severe systemic diseaseOther zoonotic infections: ranging from mild upper respiratory tract infection to severe pneumonia and death.Possible to cause conjunctivitis, GI symptoms, encephalitis and encephalopathy HA Most still retains previous host-receptor specificity [16][57,58,59]
T604 2617-2986 Sentence denotes Humans 1918-derived H1N1 (extinct), 1957-derived H2N2 (extinct), 1968-derived H3N2, 2009-derived H1N1 Pandemic and continued as seasonal flu:Primarily cause respiratory disease (usually pdm more severe, including pneumonia) HA Terminal Neu5Acα2,6GalInternal 6′S(LN)nEarly human-adapted viruses: n = 1, 2, 3, etc.Long-term circulating viruses: n ≥ 3 [16,19][60,61]
T605 2987-3063 Sentence denotes Bats Fruit-eating bats in Guatemala Sl-BatH17N10Fruit-eating bats in Peru:
T606 3064-3208 Sentence denotes Ap-batH18N11 H17: liver, intestine, lung and kidney tissues, and rectal swabsH18: intestine tissue and rectal swabs HA MHC-II HLA-DR [62,63]
T607 3209-3266 Sentence denotes Fruit-eating bats in Egypt Distinct from all known IAVs.
T608 3267-3448 Sentence denotes HAs, closest to mallard H9 viruses with 73% aa identity Viruses in bat oral swabs > in rectal swabsAble to replicate in mouse lungs HA TerminalNeu5Acα2,3Gal > Neu5Acα2,6Gal [64]
T609 3449-3557 Sentence denotes Betainfluenzavirus 8 (-)ssRNA segments B Humans, sporadically in seals, pigs, horses, pheasants and dogs.
T610 3559-3814 Sentence denotes Influenza B viruses (IBVs)2 lineages- Victoria lineage B/Victoria/2/87-like viruses- Yamagata lineage: B/Yamagata/16/88-like viruses Seasonal flu HA Wild types of both Yamagata (HA with F95 and N194) and Victoria (HA with G141, R162 and D196) lineages:
T611 3815-3961 Sentence denotes Neu5Acα2,6Gal>Neu5Acα2,3Gal2001–2007 clinical isolates in Taiwan:83% of Yamagata-like strains prefer α2,6Sia; 17% prefer both α2,3Sia and α2,6Sia.
T612 3962-4249 Sentence denotes 54% of Victoria-like strains prefer both α2,3Sia and α2,6Sia; 25% prefer sulfated glycan, either β-Gal-3-sulfate or 6-HSO3-Galβ1,4GlcNAc; 21% prefer α2,6Sia.Dual α2,3Sia and α2,6Sia-binding viruses seem to be associated with bronchopneumonia and gastrointestinal symptoms. [65,66,67,68]
T613 4250-4537 Sentence denotes Gammainfluenzavirus 7 (−)ssRNA segments C Humans (particularly in infants and children), pigs, cattle Influenza C viruses (ICVs)6 lineages: C/Taylor, C/Mississippi, C/Aichi, C/Yamagata, C/Kanagawa and C/Sao Paulo Usually mild flu HEF TerminalC/Johannesburg/1/66 (C/Aichi lineage):
T614 4538-4569 Sentence denotes Neu5,9Ac2α2,6Gal [69,70,71,72]
T615 4570-4858 Sentence denotes Deltainfluenzavirus 7 (−)ssRNA segments D Pigs, cattle,91% seropositivity found among persons working with cattle Influenza D viruses (IDVs)3 lineages: D/OK, D/660 and D/JapaneseD/Japanese lineage contains 2 sublineages: D/Yama2016 and D/Yama2019 Usually mild flu HEF TerminalD/OK:
T616 4859-4924 Sentence denotes Neu5,9Ac2 and Neu5Gc9Ac either linked to α2,6Gal or α2,3GalD/660:
T617 4925-4993 Sentence denotes Neu5,9Ac2α2,6Gal, Neu5Gc9Acα2,6Gal and Neu5Gc9Acα2,3Gal [15,72][73]
T618 4994-5000 Sentence denotes 3′SLN:
T619 5001-5057 Sentence denotes 3′sialyllactosamine (Neu5Acα2,3Galβ1,4GlcNAcβ1); 6′SLDN:
T620 5058-5516 Sentence denotes Neu5Acα2,6GalNAcβ1,4GlcNAcβ1; GI: gastrointestinal; HA: hemagglutinin; HEF: hemagglutinin-esterase-fusion; HLA-DR: human leukocyte antigen DR isotype; HP: highly pathogenic virus; IAV: influenza A virus; IBV1: influenza B virus; ICV: influenza C virus; IDV: influenza D virus; LP: low pathogenic virus; LSTb: lactoseries tetrasaccharide b (Galβ1,3(Neu5Acα2,6)GlcNAcβ1,3Galβ1,4Glcβ1); MHC-II: major histocompatibility complex II; NA: neuraminidase; Neu5,9Ac2:
T621 5517-5562 Sentence denotes 5-N-acetyl-9-O-acetylneuraminic acid; Neu5Ac:
T622 5563-5600 Sentence denotes 5-N-acetylneuraminic acid; Neu5AcGM3:
T623 5601-5643 Sentence denotes Neu5Acα2,3Galβ1,4Glcβ1-1′Ceramide; Neu5Gc:
T624 5644-5683 Sentence denotes 5-N-glycolylneuraminic acid; Neu5GcGM3:
T625 5684-5933 Sentence denotes Neu5Gcα2,3Galβ1,4Glcβ1-1′Ceramide; Sia: sialic acid; SiaLea: sialyl-Lewisa (Neu5Acα2,3Galβ1,3(Fucα1,4)GlcNAcβ1); SiaLec: sialyl-Lewisc (Neu5Acα2,3Galβ1,3GlcNAcβ1); SiaLex: sialyl-Lewisx (Neu5Acα2,3Galβ1,4(Fucα1,3)GlcNAcβ1); Sialyllacto-N-tetraose a:
T626 5934-6002 Sentence denotes Neu5Acα2,3Galβ1,3GlcNAcβ1,3Galβ1-4Glcβ1; SIV: swine influenza virus.