| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T274 |
0-168 |
Sentence |
denotes |
FBDD was first reported in 1996 [195] and used throughout the late 1990s as evidenced by the use of keywords related to FBDD in papers published during this time [196]. |
| T275 |
169-272 |
Sentence |
denotes |
The use of FBDD as a viable drug screening technique began to be widely adopted in the mid-2000s [197]. |
| T276 |
273-362 |
Sentence |
denotes |
High Throughput Screening (HTS) is another technique widely used in drug discovery [198]. |
| T277 |
363-480 |
Sentence |
denotes |
HTS analyzes molecules from a chemical library to see which ones are suitable leads [198,199,200,201] (see Figure 6). |
| T278 |
481-789 |
Sentence |
denotes |
FBDD techniques will screen against a carefully designed fragment library composed of a few thousand molecules (for details on the choice of compounds and design of fragment libraries, see [202,203]) and identified hits are further developed via fragment growing, fragment merging, or fragment linking [194]. |
| T279 |
790-899 |
Sentence |
denotes |
For examples of drugs derived from the FBDD approach that are currently in clinical trials, refer to Table 2. |
