FBDD was first reported in 1996 [195] and used throughout the late 1990s as evidenced by the use of keywords related to FBDD in papers published during this time [196]. The use of FBDD as a viable drug screening technique began to be widely adopted in the mid-2000s [197]. High Throughput Screening (HTS) is another technique widely used in drug discovery [198]. HTS analyzes molecules from a chemical library to see which ones are suitable leads [198,199,200,201] (see Figure 6). FBDD techniques will screen against a carefully designed fragment library composed of a few thousand molecules (for details on the choice of compounds and design of fragment libraries, see [202,203]) and identified hits are further developed via fragment growing, fragment merging, or fragment linking [194]. For examples of drugs derived from the FBDD approach that are currently in clinical trials, refer to Table 2.