LitCovid-sentences  

PMC:7435837 / 40283-45261 JSONTXT 9 Projects

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Id Subject Object Predicate Lexical cue
T305 0-2 Sentence denotes 7.
T306 3-30 Sentence denotes Conclusions and Perspective
T307 31-80 Sentence denotes Humanity is faced with an unprecedented pandemic.
T308 81-202 Sentence denotes It is the best-documented pandemic that the world has seen and this makes it different from previous, historic pandemics.
T309 203-322 Sentence denotes However, the SARS-CoV-2 pandemic has elicited a concerted, world effort to attempt and curb the effect of the pandemic.
T310 323-479 Sentence denotes If a cynical view is taken, humanity has to realize that this will not be the last pandemic and that potentially worse pandemics will be seen in the future.
T311 480-634 Sentence denotes The cusp of antibiotic resistance against many infectious diseases is currently being reached, yet there are even fewer defenses against viral infections.
T312 635-850 Sentence denotes However, nature has provided an abundance of tools, which with human ingenuity and unselfish behavior, can contribute greatly to the prevention of pandemics or at least help to control the spread of these pandemics.
T313 851-1001 Sentence denotes Seen only from an antiviral perspective, many efforts that were launched against other microorganisms can also be effectively applied against viruses.
T314 1002-1101 Sentence denotes Significant research efforts are focused on the treatment of coronaviruses and these will continue.
T315 1102-1207 Sentence denotes Of special interest is the employment of antiviral polysaccharide to create virucidal drugs and vaccines.
T316 1208-1278 Sentence denotes These efforts are aimed primarily at in vivo situations and treatment.
T317 1279-1394 Sentence denotes It is suggested that many of the in vivo knowledge can be applied to ex vivo, the passive effort against pathogens.
T318 1395-1503 Sentence denotes It is known that host cells and viruses interact through glycoprotein and polysaccharide-based interactions.
T319 1504-1719 Sentence denotes Therefore, the pharmacological effort is attempting to disrupt these interactions or the cellular effects that are seen after the virus and host membrane has indeed merged and the viral mechanism is put into motion.
T320 1720-1827 Sentence denotes The human body is a harsh environment and drug delivery and drug development meet these challenges head-on.
T321 1828-1991 Sentence denotes These include, for example, resistance to absorption of therapeutic agents into the body or degradation of therapeutic agents once they are absorbed into the body.
T322 1992-2128 Sentence denotes A clever strategy that is being followed against virus-host cell interaction is to exploit the polysaccharide-lectin recognition system.
T323 2129-2260 Sentence denotes In vivo efforts have shown that administered polysaccharide-based drugs can serve effectively as decoy binding targets for viruses.
T324 2261-2353 Sentence denotes Thus, the interaction with membrane-seated viral recognition mechanisms can be circumvented.
T325 2354-2536 Sentence denotes Another approach is to induce immunity by presenting polysaccharides or oligosaccharides that represent viral glycoproteins of a specific, or numerous, pathogen(s) to B- and T-cells.
T326 2537-2682 Sentence denotes These cells will recognize the xenobiotic polysaccharide and activate the immune system cascade and recognize further viruses and eliminate them.
T327 2683-2835 Sentence denotes If successful, memory cells will be formed and become active when the antigen-antibody, polysaccharide-lectin, interaction occurs in a future infection.
T328 2836-2877 Sentence denotes Our suggestion is almost unsophisticated.
T329 2878-2993 Sentence denotes It is inferred that several surfaces and substrates can be exploited as nanotraps for viruses, outside of the body.
T330 2994-3120 Sentence denotes It might not be farfetched to suggest that the naturally occurring GAGs will be sufficient to gain positive antiviral results.
T331 3121-3243 Sentence denotes GAGs are naturally occurring and abundantly available and are suitable to LbL nanocoating in their crude, unrefined state.
T332 3244-3319 Sentence denotes It might seem obvious that a layer-by-layer nanocoating strategy will work.
T333 3320-3439 Sentence denotes However, literature and patent literature surveys have not revealed a significant effort toward antiviral nanocoatings.
T334 3440-3553 Sentence denotes From the abundant bactericidal reports, it can be deduced that the LbL technique will produce antiviral surfaces.
T335 3554-3734 Sentence denotes However, we foresee success because surface recognition mechanisms between organisms, hosts, and guests, rely on similar principles and that is protein-polysaccharide interactions.
T336 3735-3860 Sentence denotes It is known that numerous polysaccharides have shown antiviral properties and hold significant promise as therapeutic agents.
T337 3861-3993 Sentence denotes It is suggested to LbL-nanocoat the polysaccharides onto several environmental structures with which humans come into contact daily.
T338 3994-4287 Sentence denotes We are also optimistic enough to state that researchers in an industry can be successful in this effort since the technique of LbL nanocoating is straightforward, robust, and based on many types of intermolecular forces that can almost guarantee adhesion of materials to a surface of any kind.
T339 4288-4444 Sentence denotes Numerous examples of LbL nanocoating have been found and described that coat commonly encountered surfaces and produce antibacterial and antifungal actions.
T340 4445-4552 Sentence denotes Investigation of the antiviral effects of polysaccharide LbL coatings should be investigated and developed.
T341 4553-4720 Sentence denotes This is an aspect of LbL nanocoating that has not been investigated to a large extent and is a very lucrative option for antiviral research and industrial cooperation.
T342 4721-4789 Sentence denotes The human, airborne coronavirus are ideal targets for this endeavor.
T343 4790-4978 Sentence denotes Polysaccharides, in vivo or ex vivo, should be explored for their antiviral applications, especially against coronavirus infections that may be recurring or more frequent in our existence.