PubMed:16371368 / 108-426
Annnotations
sonoma2
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T-0 | 0-9 | VAR | denotes | Mutations |
T-1 | 13-18 | GENE | denotes | SHP-2 |
T-2 | 36-41 | REG | denotes | cause |
T-3 | 42-57 | POSREG | denotes | hyperactivation |
T-4 | 65-83 | MPA | denotes | catalytic activity |
T-5 | 94-104 | REG | denotes | identified |
T-6 | 114-123 | DISEASE | denotes | leukemias |
T-7 | 138-170 | DISEASE | denotes | juvenile myelomonocytic leukemia |
T-8 | 181-194 | REG | denotes | characterized |
T-9 | 198-214 | POSREG | denotes | hypersensitivity |
T-10 | 218-242 | CPA | denotes | myeloid progenitor cells |
T-11 | 246-294 | GENE | denotes | granulocyte macrophage colony-stimulating factor |
T-12 | 299-317 | GENE | denotes | interleukin (IL)-3 |
R-0 | T-0 | T-2 | CauseOf | Mutations,cause |
R-1 | T-0 | T-3 | CauseOf | Mutations,hyperactivation |
R-2 | T-0 | T-9 | CauseOf | Mutations,hypersensitivity |
R-3 | T-1 | T-0 | ThemeOf | SHP-2,Mutations |
R-4 | T-4 | T-3 | ThemeOf | catalytic activity,hyperactivation |
R-5 | T-4 | T-5 | ThemeOf | catalytic activity,identified |
R-6 | T-6 | T-3 | ThemeOf | leukemias,hyperactivation |
R-7 | T-6 | T-5 | ThemeOf | leukemias,identified |
R-8 | T-6 | T-8 | ThemeOf | leukemias,characterized |
R-9 | T-6 | T-9 | ThemeOf | leukemias,hypersensitivity |
R-10 | T-7 | T-2 | ThemeOf | juvenile myelomonocytic leukemia,cause |
R-11 | T-7 | T-3 | ThemeOf | juvenile myelomonocytic leukemia,hyperactivation |
R-12 | T-7 | T-5 | ThemeOf | juvenile myelomonocytic leukemia,identified |
R-13 | T-7 | T-8 | ThemeOf | juvenile myelomonocytic leukemia,characterized |
R-14 | T-7 | T-9 | ThemeOf | juvenile myelomonocytic leukemia,hypersensitivity |
R-15 | T-9 | T-8 | ThemeOf | hypersensitivity,characterized |
R-16 | T-10 | T-9 | ThemeOf | myeloid progenitor cells,hypersensitivity |
R-17 | T-10 | T-8 | ThemeOf | myeloid progenitor cells,characterized |
R-18 | T-11 | T-8 | ThemeOf | granulocyte macrophage colony-stimulating factor,characterized |
R-19 | T-11 | T-9 | ThemeOf | granulocyte macrophage colony-stimulating factor,hypersensitivity |
R-20 | T-11 | T-10 | ThemeOf | granulocyte macrophage colony-stimulating factor,myeloid progenitor cells |
R-21 | T-12 | T-9 | ThemeOf | interleukin (IL)-3,hypersensitivity |
R-22 | T-12 | T-10 | ThemeOf | interleukin (IL)-3,myeloid progenitor cells |
sonoma
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T-4 | 0-9 | VAR | denotes | Mutations |
T-5 | 13-30 | GENE | denotes | SHP-2 phosphatase |
T-6 | 36-41 | REG | denotes | cause |
T-7 | 42-57 | POSREG | denotes | hyperactivation |
T-8 | 65-83 | MPA | denotes | catalytic activity |
T-9 | 94-104 | REG | denotes | identified |
T-10 | 114-123 | DISEASE | denotes | leukemias |
T-11 | 138-170 | DISEASE | denotes | juvenile myelomonocytic leukemia |
T-12 | 181-194 | REG | denotes | characterized |
T-13 | 198-214 | POSREG | denotes | hypersensitivity |
R-5 | T-4 | T-5 | ThemeOf | Mutations,SHP-2 phosphatase |
R-6 | T-4 | T-6 | CauseOf | Mutations,cause |
R-7 | T-4 | T-7 | CauseOf | Mutations,hyperactivation |
R-8 | T-4 | T-9 | CauseOf | Mutations,identified |
R-9 | T-4 | T-12 | CauseOf | Mutations,characterized |
R-10 | T-4 | T-13 | CauseOf | Mutations,hypersensitivity |
R-11 | T-5 | T-10 | A | SHP-2 phosphatase,leukemias |
R-12 | T-5 | T-11 | A | SHP-2 phosphatase,juvenile myelomonocytic leukemia |
R-13 | T-6 | T-8 | ThemeOf | cause,catalytic activity |
R-14 | T-6 | T-10 | ThemeOf | cause,leukemias |
R-15 | T-6 | T-11 | ThemeOf | cause,juvenile myelomonocytic leukemia |
R-16 | T-7 | T-8 | ThemeOf | hyperactivation,catalytic activity |
R-17 | T-7 | T-9 | ThemeOf | hyperactivation,identified |
R-18 | T-7 | T-10 | ThemeOf | hyperactivation,leukemias |
R-19 | T-7 | T-11 | ThemeOf | hyperactivation,juvenile myelomonocytic leukemia |
R-20 | T-8 | T-9 | ThemeOf | catalytic activity,identified |
R-21 | T-8 | T-12 | ThemeOf | catalytic activity,characterized |
R-22 | T-8 | T-13 | ThemeOf | catalytic activity,hypersensitivity |
R-23 | T-9 | T-10 | ThemeOf | identified,leukemias |
R-24 | T-9 | T-11 | ThemeOf | identified,juvenile myelomonocytic leukemia |
R-25 | T-9 | T-12 | ThemeOf | identified,characterized |
R-26 | T-10 | T-12 | ThemeOf | leukemias,characterized |
R-27 | T-10 | T-13 | ThemeOf | leukemias,hypersensitivity |
R-28 | T-11 | T-12 | ThemeOf | juvenile myelomonocytic leukemia,characterized |
R-29 | T-11 | T-13 | ThemeOf | juvenile myelomonocytic leukemia,hypersensitivity |
R-30 | T-12 | T-13 | ThemeOf | characterized,hypersensitivity |
sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T2 | 0-318 | Sentence | denotes | Mutations in SHP-2 phosphatase that cause hyperactivation of its catalytic activity have been identified in human leukemias, particularly juvenile myelomonocytic leukemia, which is characterized by hypersensitivity of myeloid progenitor cells to granulocyte macrophage colony-stimulating factor and interleukin (IL)-3. |
PubmedHPO
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 42-57 | HP_0000752 | denotes | hyperactivation |
T2 | 114-123 | HP_0001909 | denotes | leukemias |
T3 | 138-170 | HP_0012209 | denotes | juvenile myelomonocytic leukemia |
T4 | 162-170 | HP_0001909 | denotes | leukemia |
DisGeNET5_gene_disease
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
16371368-1#246#294#gene1437 | 246-294 | gene1437 | denotes | granulocyte macrophage colony-stimulating factor |
16371368-1#138#170#diseaseC0349639 | 138-170 | diseaseC0349639 | denotes | juvenile myelomonocytic leukemia |
246#294#gene1437138#170#diseaseC0349639 | 16371368-1#246#294#gene1437 | 16371368-1#138#170#diseaseC0349639 | associated_with | granulocyte macrophage colony-stimulating factor,juvenile myelomonocytic leukemia |
kaiyin_test
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 0-9 | Var | denotes | Mutations |
T2 | 13-18 | Gene | denotes | SHP-2 |
T3 | 19-30 | Enzyme | denotes | phosphatase |
T4 | 42-57 | PosReg | denotes | hyperactivation |
T5 | 65-83 | MPA | denotes | catalytic activity |
T33 | 108-123 | Disease | denotes | human leukemias |
T34 | 138-170 | Disease | denotes | juvenile myelomonocytic leukemia |
R1 | T3 | T2 | ThemeOf | phosphatase,SHP-2 |
R2 | T2 | T1 | ThemeOf | SHP-2,Mutations |
R3 | T1 | T4 | CauseOf | Mutations,hyperactivation |
R4 | T5 | T4 | ThemeOf | catalytic activity,hyperactivation |
name_no
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 0-9 | Var | denotes | Mutations |
T2 | 13-18 | Gene | denotes | SHP-2 |
T3 | 19-30 | Enzyme | denotes | phosphatase |
T4 | 42-57 | PosReg | denotes | hyperactivation |
T5 | 65-83 | MPA | denotes | catalytic activity |
T33 | 108-123 | Disease | denotes | human leukemias |
T34 | 138-170 | Disease | denotes | juvenile myelomonocytic leukemia |
R1 | T3 | T2 | ThemeOf | phosphatase,SHP-2 |
R2 | T2 | T1 | ThemeOf | SHP-2,Mutations |
R3 | T1 | T4 | CauseOf | Mutations,hyperactivation |
R4 | T5 | T4 | ThemeOf | catalytic activity,hyperactivation |
mondo_disease
Id | Subject | Object | Predicate | Lexical cue | mondo_id |
---|---|---|---|---|---|
T2 | 114-123 | Disease | denotes | leukemias | http://purl.obolibrary.org/obo/MONDO_0005059 |
T3 | 138-170 | Disease | denotes | juvenile myelomonocytic leukemia | http://purl.obolibrary.org/obo/MONDO_0011908 |
T4 | 198-214 | Disease | denotes | hypersensitivity | http://purl.obolibrary.org/obo/MONDO_0000605|http://purl.obolibrary.org/obo/MONDO_0005271 |
HP-phenotype
Id | Subject | Object | Predicate | Lexical cue | hp_id |
---|---|---|---|---|---|
T2 | 138-170 | Phenotype | denotes | juvenile myelomonocytic leukemia | HP:0012209 |
T3 | 198-214 | Phenotype | denotes | hypersensitivity | HP:0041092 |
NCBITAXON
Id | Subject | Object | Predicate | Lexical cue | db_id |
---|---|---|---|---|---|
T1 | 108-113 | OrganismTaxon | denotes | human | 9606 |
Anatomy-UBERON
Id | Subject | Object | Predicate | Lexical cue | uberon_id |
---|---|---|---|---|---|
T1 | 138-146 | Body_part | denotes | juvenile | http://purl.obolibrary.org/obo/UBERON_0007021 |
T2 | 218-242 | Body_part | denotes | myeloid progenitor cells | http://purl.obolibrary.org/obo/CL_0000839 |
T3 | 246-257 | Body_part | denotes | granulocyte | http://purl.obolibrary.org/obo/CL_0000094 |
T4 | 258-268 | Body_part | denotes | macrophage | http://purl.obolibrary.org/obo/CL_0000235 |
CL-cell
Id | Subject | Object | Predicate | Lexical cue | cl_id |
---|---|---|---|---|---|
T1 | 218-242 | Cell | denotes | myeloid progenitor cells | http://purl.obolibrary.org/obo/CL:0000839 |
T2 | 246-257 | Cell | denotes | granulocyte | http://purl.obolibrary.org/obo/CL:0000094 |
T3 | 258-268 | Cell | denotes | macrophage | http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394 |