PubMed:16371368 / 108-426 JSONTXT

{"project":"sonoma2","denotations":[{"id":"T-0","span":{"begin":0,"end":9},"obj":"VAR"},{"id":"T-1","span":{"begin":13,"end":18},"obj":"GENE"},{"id":"T-2","span":{"begin":36,"end":41},"obj":"REG"},{"id":"T-3","span":{"begin":42,"end":57},"obj":"POSREG"},{"id":"T-4","span":{"begin":65,"end":83},"obj":"MPA"},{"id":"T-5","span":{"begin":94,"end":104},"obj":"REG"},{"id":"T-6","span":{"begin":114,"end":123},"obj":"DISEASE"},{"id":"T-7","span":{"begin":138,"end":170},"obj":"DISEASE"},{"id":"T-8","span":{"begin":181,"end":194},"obj":"REG"},{"id":"T-9","span":{"begin":198,"end":214},"obj":"POSREG"},{"id":"T-10","span":{"begin":218,"end":242},"obj":"CPA"},{"id":"T-11","span":{"begin":246,"end":294},"obj":"GENE"},{"id":"T-12","span":{"begin":299,"end":317},"obj":"GENE"}],"relations":[{"id":"R-0","pred":"CauseOf","subj":"T-0","obj":"T-2"},{"id":"R-1","pred":"CauseOf","subj":"T-0","obj":"T-3"},{"id":"R-2","pred":"CauseOf","subj":"T-0","obj":"T-9"},{"id":"R-3","pred":"ThemeOf","subj":"T-1","obj":"T-0"},{"id":"R-4","pred":"ThemeOf","subj":"T-4","obj":"T-3"},{"id":"R-5","pred":"ThemeOf","subj":"T-4","obj":"T-5"},{"id":"R-6","pred":"ThemeOf","subj":"T-6","obj":"T-3"},{"id":"R-7","pred":"ThemeOf","subj":"T-6","obj":"T-5"},{"id":"R-8","pred":"ThemeOf","subj":"T-6","obj":"T-8"},{"id":"R-9","pred":"ThemeOf","subj":"T-6","obj":"T-9"},{"id":"R-10","pred":"ThemeOf","subj":"T-7","obj":"T-2"},{"id":"R-11","pred":"ThemeOf","subj":"T-7","obj":"T-3"},{"id":"R-12","pred":"ThemeOf","subj":"T-7","obj":"T-5"},{"id":"R-13","pred":"ThemeOf","subj":"T-7","obj":"T-8"},{"id":"R-14","pred":"ThemeOf","subj":"T-7","obj":"T-9"},{"id":"R-15","pred":"ThemeOf","subj":"T-9","obj":"T-8"},{"id":"R-16","pred":"ThemeOf","subj":"T-10","obj":"T-9"},{"id":"R-17","pred":"ThemeOf","subj":"T-10","obj":"T-8"},{"id":"R-18","pred":"ThemeOf","subj":"T-11","obj":"T-8"},{"id":"R-19","pred":"ThemeOf","subj":"T-11","obj":"T-9"},{"id":"R-20","pred":"ThemeOf","subj":"T-11","obj":"T-10"},{"id":"R-21","pred":"ThemeOf","subj":"T-12","obj":"T-9"},{"id":"R-22","pred":"ThemeOf","subj":"T-12","obj":"T-10"}],"text":"Mutations in SHP-2 phosphatase that cause hyperactivation of its catalytic activity have been identified in human leukemias, particularly juvenile myelomonocytic leukemia, which is characterized by hypersensitivity of myeloid progenitor cells to granulocyte macrophage colony-stimulating factor and interleukin (IL)-3."}

{"project":"sonoma","denotations":[{"id":"T-4","span":{"begin":0,"end":9},"obj":"VAR"},{"id":"T-5","span":{"begin":13,"end":30},"obj":"GENE"},{"id":"T-6","span":{"begin":36,"end":41},"obj":"REG"},{"id":"T-7","span":{"begin":42,"end":57},"obj":"POSREG"},{"id":"T-8","span":{"begin":65,"end":83},"obj":"MPA"},{"id":"T-9","span":{"begin":94,"end":104},"obj":"REG"},{"id":"T-10","span":{"begin":114,"end":123},"obj":"DISEASE"},{"id":"T-11","span":{"begin":138,"end":170},"obj":"DISEASE"},{"id":"T-12","span":{"begin":181,"end":194},"obj":"REG"},{"id":"T-13","span":{"begin":198,"end":214},"obj":"POSREG"}],"relations":[{"id":"R-5","pred":"ThemeOf","subj":"T-4","obj":"T-5"},{"id":"R-6","pred":"CauseOf","subj":"T-4","obj":"T-6"},{"id":"R-7","pred":"CauseOf","subj":"T-4","obj":"T-7"},{"id":"R-8","pred":"CauseOf","subj":"T-4","obj":"T-9"},{"id":"R-9","pred":"CauseOf","subj":"T-4","obj":"T-12"},{"id":"R-10","pred":"CauseOf","subj":"T-4","obj":"T-13"},{"id":"R-11","pred":"A","subj":"T-5","obj":"T-10"},{"id":"R-12","pred":"A","subj":"T-5","obj":"T-11"},{"id":"R-13","pred":"ThemeOf","subj":"T-6","obj":"T-8"},{"id":"R-14","pred":"ThemeOf","subj":"T-6","obj":"T-10"},{"id":"R-15","pred":"ThemeOf","subj":"T-6","obj":"T-11"},{"id":"R-16","pred":"ThemeOf","subj":"T-7","obj":"T-8"},{"id":"R-17","pred":"ThemeOf","subj":"T-7","obj":"T-9"},{"id":"R-18","pred":"ThemeOf","subj":"T-7","obj":"T-10"},{"id":"R-19","pred":"ThemeOf","subj":"T-7","obj":"T-11"},{"id":"R-20","pred":"ThemeOf","subj":"T-8","obj":"T-9"},{"id":"R-21","pred":"ThemeOf","subj":"T-8","obj":"T-12"},{"id":"R-22","pred":"ThemeOf","subj":"T-8","obj":"T-13"},{"id":"R-23","pred":"ThemeOf","subj":"T-9","obj":"T-10"},{"id":"R-24","pred":"ThemeOf","subj":"T-9","obj":"T-11"},{"id":"R-25","pred":"ThemeOf","subj":"T-9","obj":"T-12"},{"id":"R-26","pred":"ThemeOf","subj":"T-10","obj":"T-12"},{"id":"R-27","pred":"ThemeOf","subj":"T-10","obj":"T-13"},{"id":"R-28","pred":"ThemeOf","subj":"T-11","obj":"T-12"},{"id":"R-29","pred":"ThemeOf","subj":"T-11","obj":"T-13"},{"id":"R-30","pred":"ThemeOf","subj":"T-12","obj":"T-13"}],"text":"Mutations in SHP-2 phosphatase that cause hyperactivation of its catalytic activity have been identified in human leukemias, particularly juvenile myelomonocytic leukemia, which is characterized by hypersensitivity of myeloid progenitor cells to granulocyte macrophage colony-stimulating factor and interleukin (IL)-3."}

{"project":"sentences","denotations":[{"id":"T2","span":{"begin":0,"end":318},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Mutations in SHP-2 phosphatase that cause hyperactivation of its catalytic activity have been identified in human leukemias, particularly juvenile myelomonocytic leukemia, which is characterized by hypersensitivity of myeloid progenitor cells to granulocyte macrophage colony-stimulating factor and interleukin (IL)-3."}

{"project":"PubmedHPO","denotations":[{"id":"T1","span":{"begin":42,"end":57},"obj":"HP_0000752"},{"id":"T2","span":{"begin":114,"end":123},"obj":"HP_0001909"},{"id":"T3","span":{"begin":138,"end":170},"obj":"HP_0012209"},{"id":"T4","span":{"begin":162,"end":170},"obj":"HP_0001909"}],"text":"Mutations in SHP-2 phosphatase that cause hyperactivation of its catalytic activity have been identified in human leukemias, particularly juvenile myelomonocytic leukemia, which is characterized by hypersensitivity of myeloid progenitor cells to granulocyte macrophage colony-stimulating factor and interleukin (IL)-3."}

{"project":"DisGeNET5_gene_disease","denotations":[{"id":"16371368-1#246#294#gene1437","span":{"begin":246,"end":294},"obj":"gene1437"},{"id":"16371368-1#138#170#diseaseC0349639","span":{"begin":138,"end":170},"obj":"diseaseC0349639"}],"relations":[{"id":"246#294#gene1437138#170#diseaseC0349639","pred":"associated_with","subj":"16371368-1#246#294#gene1437","obj":"16371368-1#138#170#diseaseC0349639"}],"text":"Mutations in SHP-2 phosphatase that cause hyperactivation of its catalytic activity have been identified in human leukemias, particularly juvenile myelomonocytic leukemia, which is characterized by hypersensitivity of myeloid progenitor cells to granulocyte macrophage colony-stimulating factor and interleukin (IL)-3."}

{"project":"kaiyin_test","denotations":[{"id":"T1","span":{"begin":0,"end":9},"obj":"Var"},{"id":"T2","span":{"begin":13,"end":18},"obj":"Gene"},{"id":"T3","span":{"begin":19,"end":30},"obj":"Enzyme"},{"id":"T4","span":{"begin":42,"end":57},"obj":"PosReg"},{"id":"T5","span":{"begin":65,"end":83},"obj":"MPA"},{"id":"T33","span":{"begin":108,"end":123},"obj":"Disease"},{"id":"T34","span":{"begin":138,"end":170},"obj":"Disease"}],"relations":[{"id":"R1","pred":"ThemeOf","subj":"T3","obj":"T2"},{"id":"R2","pred":"ThemeOf","subj":"T2","obj":"T1"},{"id":"R3","pred":"CauseOf","subj":"T1","obj":"T4"},{"id":"R4","pred":"ThemeOf","subj":"T5","obj":"T4"}],"text":"Mutations in SHP-2 phosphatase that cause hyperactivation of its catalytic activity have been identified in human leukemias, particularly juvenile myelomonocytic leukemia, which is characterized by hypersensitivity of myeloid progenitor cells to granulocyte macrophage colony-stimulating factor and interleukin (IL)-3."}

{"project":"name_no","denotations":[{"id":"T1","span":{"begin":0,"end":9},"obj":"Var"},{"id":"T2","span":{"begin":13,"end":18},"obj":"Gene"},{"id":"T3","span":{"begin":19,"end":30},"obj":"Enzyme"},{"id":"T4","span":{"begin":42,"end":57},"obj":"PosReg"},{"id":"T5","span":{"begin":65,"end":83},"obj":"MPA"},{"id":"T33","span":{"begin":108,"end":123},"obj":"Disease"},{"id":"T34","span":{"begin":138,"end":170},"obj":"Disease"}],"relations":[{"id":"R1","pred":"ThemeOf","subj":"T3","obj":"T2"},{"id":"R2","pred":"ThemeOf","subj":"T2","obj":"T1"},{"id":"R3","pred":"CauseOf","subj":"T1","obj":"T4"},{"id":"R4","pred":"ThemeOf","subj":"T5","obj":"T4"}],"text":"Mutations in SHP-2 phosphatase that cause hyperactivation of its catalytic activity have been identified in human leukemias, particularly juvenile myelomonocytic leukemia, which is characterized by hypersensitivity of myeloid progenitor cells to granulocyte macrophage colony-stimulating factor and interleukin (IL)-3."}

{"project":"mondo_disease","denotations":[{"id":"T2","span":{"begin":114,"end":123},"obj":"Disease"},{"id":"T3","span":{"begin":138,"end":170},"obj":"Disease"},{"id":"T4","span":{"begin":198,"end":214},"obj":"Disease"}],"attributes":[{"id":"A2","pred":"mondo_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/MONDO_0005059"},{"id":"A3","pred":"mondo_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/MONDO_0011908"},{"id":"A4","pred":"mondo_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/MONDO_0000605"},{"id":"A5","pred":"mondo_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/MONDO_0005271"}],"text":"Mutations in SHP-2 phosphatase that cause hyperactivation of its catalytic activity have been identified in human leukemias, particularly juvenile myelomonocytic leukemia, which is characterized by hypersensitivity of myeloid progenitor cells to granulocyte macrophage colony-stimulating factor and interleukin (IL)-3."}

{"project":"HP-phenotype","denotations":[{"id":"T2","span":{"begin":138,"end":170},"obj":"Phenotype"},{"id":"T3","span":{"begin":198,"end":214},"obj":"Phenotype"}],"attributes":[{"id":"A2","pred":"hp_id","subj":"T2","obj":"HP:0012209"},{"id":"A3","pred":"hp_id","subj":"T3","obj":"HP:0041092"}],"namespaces":[{"prefix":"HP","uri":"http://purl.obolibrary.org/obo/HP_"}],"text":"Mutations in SHP-2 phosphatase that cause hyperactivation of its catalytic activity have been identified in human leukemias, particularly juvenile myelomonocytic leukemia, which is characterized by hypersensitivity of myeloid progenitor cells to granulocyte macrophage colony-stimulating factor and interleukin (IL)-3."}

{"project":"NCBITAXON","denotations":[{"id":"T1","span":{"begin":108,"end":113},"obj":"OrganismTaxon"}],"attributes":[{"id":"A1","pred":"db_id","subj":"T1","obj":"9606"}],"text":"Mutations in SHP-2 phosphatase that cause hyperactivation of its catalytic activity have been identified in human leukemias, particularly juvenile myelomonocytic leukemia, which is characterized by hypersensitivity of myeloid progenitor cells to granulocyte macrophage colony-stimulating factor and interleukin (IL)-3."}

{"project":"Anatomy-UBERON","denotations":[{"id":"T1","span":{"begin":138,"end":146},"obj":"Body_part"},{"id":"T2","span":{"begin":218,"end":242},"obj":"Body_part"},{"id":"T3","span":{"begin":246,"end":257},"obj":"Body_part"},{"id":"T4","span":{"begin":258,"end":268},"obj":"Body_part"}],"attributes":[{"id":"A1","pred":"uberon_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/UBERON_0007021"},{"id":"A2","pred":"uberon_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/CL_0000839"},{"id":"A3","pred":"uberon_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/CL_0000094"},{"id":"A4","pred":"uberon_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/CL_0000235"}],"text":"Mutations in SHP-2 phosphatase that cause hyperactivation of its catalytic activity have been identified in human leukemias, particularly juvenile myelomonocytic leukemia, which is characterized by hypersensitivity of myeloid progenitor cells to granulocyte macrophage colony-stimulating factor and interleukin (IL)-3."}

{"project":"CL-cell","denotations":[{"id":"T1","span":{"begin":218,"end":242},"obj":"Cell"},{"id":"T2","span":{"begin":246,"end":257},"obj":"Cell"},{"id":"T3","span":{"begin":258,"end":268},"obj":"Cell"}],"attributes":[{"id":"A1","pred":"cl_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/CL:0000839"},{"id":"A2","pred":"cl_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/CL:0000094"},{"id":"A3","pred":"cl_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/CL:0000235"},{"id":"A4","pred":"cl_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/CL:0000394"}],"text":"Mutations in SHP-2 phosphatase that cause hyperactivation of its catalytic activity have been identified in human leukemias, particularly juvenile myelomonocytic leukemia, which is characterized by hypersensitivity of myeloid progenitor cells to granulocyte macrophage colony-stimulating factor and interleukin (IL)-3."}