PubMed:16371368 / 108-426 JSONTXT

Annnotations TAB JSON ListView MergeView

{"target":"http://pubannotation.org/docs/sourcedb/PubMed/sourceid/16371368","sourcedb":"PubMed","sourceid":"16371368","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/16371368","text":"Mutations in SHP-2 phosphatase that cause hyperactivation of its catalytic activity have been identified in human leukemias, particularly juvenile myelomonocytic leukemia, which is characterized by hypersensitivity of myeloid progenitor cells to granulocyte macrophage colony-stimulating factor and interleukin (IL)-3.","tracks":[{"project":"sonoma2","denotations":[{"id":"T-0","span":{"begin":0,"end":9},"obj":"VAR"},{"id":"T-1","span":{"begin":13,"end":18},"obj":"GENE"},{"id":"T-2","span":{"begin":36,"end":41},"obj":"REG"},{"id":"T-3","span":{"begin":42,"end":57},"obj":"POSREG"},{"id":"T-4","span":{"begin":65,"end":83},"obj":"MPA"},{"id":"T-5","span":{"begin":94,"end":104},"obj":"REG"},{"id":"T-6","span":{"begin":114,"end":123},"obj":"DISEASE"},{"id":"T-7","span":{"begin":138,"end":170},"obj":"DISEASE"},{"id":"T-8","span":{"begin":181,"end":194},"obj":"REG"},{"id":"T-9","span":{"begin":198,"end":214},"obj":"POSREG"},{"id":"T-10","span":{"begin":218,"end":242},"obj":"CPA"},{"id":"T-11","span":{"begin":246,"end":294},"obj":"GENE"},{"id":"T-12","span":{"begin":299,"end":317},"obj":"GENE"}],"relations":[{"id":"R-0","pred":"CauseOf","subj":"T-0","obj":"T-2"},{"id":"R-1","pred":"CauseOf","subj":"T-0","obj":"T-3"},{"id":"R-2","pred":"CauseOf","subj":"T-0","obj":"T-9"},{"id":"R-3","pred":"ThemeOf","subj":"T-1","obj":"T-0"},{"id":"R-4","pred":"ThemeOf","subj":"T-4","obj":"T-3"},{"id":"R-5","pred":"ThemeOf","subj":"T-4","obj":"T-5"},{"id":"R-6","pred":"ThemeOf","subj":"T-6","obj":"T-3"},{"id":"R-7","pred":"ThemeOf","subj":"T-6","obj":"T-5"},{"id":"R-8","pred":"ThemeOf","subj":"T-6","obj":"T-8"},{"id":"R-9","pred":"ThemeOf","subj":"T-6","obj":"T-9"},{"id":"R-10","pred":"ThemeOf","subj":"T-7","obj":"T-2"},{"id":"R-11","pred":"ThemeOf","subj":"T-7","obj":"T-3"},{"id":"R-12","pred":"ThemeOf","subj":"T-7","obj":"T-5"},{"id":"R-13","pred":"ThemeOf","subj":"T-7","obj":"T-8"},{"id":"R-14","pred":"ThemeOf","subj":"T-7","obj":"T-9"},{"id":"R-15","pred":"ThemeOf","subj":"T-9","obj":"T-8"},{"id":"R-16","pred":"ThemeOf","subj":"T-10","obj":"T-9"},{"id":"R-17","pred":"ThemeOf","subj":"T-10","obj":"T-8"},{"id":"R-18","pred":"ThemeOf","subj":"T-11","obj":"T-8"},{"id":"R-19","pred":"ThemeOf","subj":"T-11","obj":"T-9"},{"id":"R-20","pred":"ThemeOf","subj":"T-11","obj":"T-10"},{"id":"R-21","pred":"ThemeOf","subj":"T-12","obj":"T-9"},{"id":"R-22","pred":"ThemeOf","subj":"T-12","obj":"T-10"}],"attributes":[{"subj":"T-0","pred":"source","obj":"sonoma2"},{"subj":"T-1","pred":"source","obj":"sonoma2"},{"subj":"T-2","pred":"source","obj":"sonoma2"},{"subj":"T-3","pred":"source","obj":"sonoma2"},{"subj":"T-4","pred":"source","obj":"sonoma2"},{"subj":"T-5","pred":"source","obj":"sonoma2"},{"subj":"T-6","pred":"source","obj":"sonoma2"},{"subj":"T-7","pred":"source","obj":"sonoma2"},{"subj":"T-8","pred":"source","obj":"sonoma2"},{"subj":"T-9","pred":"source","obj":"sonoma2"},{"subj":"T-10","pred":"source","obj":"sonoma2"},{"subj":"T-11","pred":"source","obj":"sonoma2"},{"subj":"T-12","pred":"source","obj":"sonoma2"}]},{"project":"sonoma","denotations":[{"id":"T-4","span":{"begin":0,"end":9},"obj":"VAR"},{"id":"T-5","span":{"begin":13,"end":30},"obj":"GENE"},{"id":"T-6","span":{"begin":36,"end":41},"obj":"REG"},{"id":"T-7","span":{"begin":42,"end":57},"obj":"POSREG"},{"id":"T-8","span":{"begin":65,"end":83},"obj":"MPA"},{"id":"T-9","span":{"begin":94,"end":104},"obj":"REG"},{"id":"T-10","span":{"begin":114,"end":123},"obj":"DISEASE"},{"id":"T-11","span":{"begin":138,"end":170},"obj":"DISEASE"},{"id":"T-12","span":{"begin":181,"end":194},"obj":"REG"},{"id":"T-13","span":{"begin":198,"end":214},"obj":"POSREG"}],"relations":[{"id":"R-5","pred":"ThemeOf","subj":"T-4","obj":"T-5"},{"id":"R-6","pred":"CauseOf","subj":"T-4","obj":"T-6"},{"id":"R-7","pred":"CauseOf","subj":"T-4","obj":"T-7"},{"id":"R-8","pred":"CauseOf","subj":"T-4","obj":"T-9"},{"id":"R-9","pred":"CauseOf","subj":"T-4","obj":"T-12"},{"id":"R-10","pred":"CauseOf","subj":"T-4","obj":"T-13"},{"id":"R-11","pred":"A","subj":"T-5","obj":"T-10"},{"id":"R-12","pred":"A","subj":"T-5","obj":"T-11"},{"id":"R-13","pred":"ThemeOf","subj":"T-6","obj":"T-8"},{"id":"R-14","pred":"ThemeOf","subj":"T-6","obj":"T-10"},{"id":"R-15","pred":"ThemeOf","subj":"T-6","obj":"T-11"},{"id":"R-16","pred":"ThemeOf","subj":"T-7","obj":"T-8"},{"id":"R-17","pred":"ThemeOf","subj":"T-7","obj":"T-9"},{"id":"R-18","pred":"ThemeOf","subj":"T-7","obj":"T-10"},{"id":"R-19","pred":"ThemeOf","subj":"T-7","obj":"T-11"},{"id":"R-20","pred":"ThemeOf","subj":"T-8","obj":"T-9"},{"id":"R-21","pred":"ThemeOf","subj":"T-8","obj":"T-12"},{"id":"R-22","pred":"ThemeOf","subj":"T-8","obj":"T-13"},{"id":"R-23","pred":"ThemeOf","subj":"T-9","obj":"T-10"},{"id":"R-24","pred":"ThemeOf","subj":"T-9","obj":"T-11"},{"id":"R-25","pred":"ThemeOf","subj":"T-9","obj":"T-12"},{"id":"R-26","pred":"ThemeOf","subj":"T-10","obj":"T-12"},{"id":"R-27","pred":"ThemeOf","subj":"T-10","obj":"T-13"},{"id":"R-28","pred":"ThemeOf","subj":"T-11","obj":"T-12"},{"id":"R-29","pred":"ThemeOf","subj":"T-11","obj":"T-13"},{"id":"R-30","pred":"ThemeOf","subj":"T-12","obj":"T-13"}],"attributes":[{"subj":"T-4","pred":"source","obj":"sonoma"},{"subj":"T-5","pred":"source","obj":"sonoma"},{"subj":"T-6","pred":"source","obj":"sonoma"},{"subj":"T-7","pred":"source","obj":"sonoma"},{"subj":"T-8","pred":"source","obj":"sonoma"},{"subj":"T-9","pred":"source","obj":"sonoma"},{"subj":"T-10","pred":"source","obj":"sonoma"},{"subj":"T-11","pred":"source","obj":"sonoma"},{"subj":"T-12","pred":"source","obj":"sonoma"},{"subj":"T-13","pred":"source","obj":"sonoma"}]},{"project":"sentences","denotations":[{"id":"T2","span":{"begin":0,"end":318},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T2","pred":"source","obj":"sentences"}]},{"project":"PubmedHPO","denotations":[{"id":"T1","span":{"begin":42,"end":57},"obj":"HP_0000752"},{"id":"T2","span":{"begin":114,"end":123},"obj":"HP_0001909"},{"id":"T3","span":{"begin":138,"end":170},"obj":"HP_0012209"},{"id":"T4","span":{"begin":162,"end":170},"obj":"HP_0001909"}],"attributes":[{"subj":"T1","pred":"source","obj":"PubmedHPO"},{"subj":"T2","pred":"source","obj":"PubmedHPO"},{"subj":"T3","pred":"source","obj":"PubmedHPO"},{"subj":"T4","pred":"source","obj":"PubmedHPO"}]},{"project":"DisGeNET5_gene_disease","denotations":[{"id":"16371368-1#246#294#gene1437","span":{"begin":246,"end":294},"obj":"gene1437"},{"id":"16371368-1#138#170#diseaseC0349639","span":{"begin":138,"end":170},"obj":"diseaseC0349639"}],"relations":[{"id":"246#294#gene1437138#170#diseaseC0349639","pred":"associated_with","subj":"16371368-1#246#294#gene1437","obj":"16371368-1#138#170#diseaseC0349639"}],"attributes":[{"subj":"16371368-1#246#294#gene1437","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"16371368-1#138#170#diseaseC0349639","pred":"source","obj":"DisGeNET5_gene_disease"}]},{"project":"kaiyin_test","denotations":[{"id":"T1","span":{"begin":0,"end":9},"obj":"Var"},{"id":"T2","span":{"begin":13,"end":18},"obj":"Gene"},{"id":"T3","span":{"begin":19,"end":30},"obj":"Enzyme"},{"id":"T4","span":{"begin":42,"end":57},"obj":"PosReg"},{"id":"T5","span":{"begin":65,"end":83},"obj":"MPA"},{"id":"T33","span":{"begin":108,"end":123},"obj":"Disease"},{"id":"T34","span":{"begin":138,"end":170},"obj":"Disease"}],"relations":[{"id":"R1","pred":"ThemeOf","subj":"T3","obj":"T2"},{"id":"R2","pred":"ThemeOf","subj":"T2","obj":"T1"},{"id":"R3","pred":"CauseOf","subj":"T1","obj":"T4"},{"id":"R4","pred":"ThemeOf","subj":"T5","obj":"T4"}],"attributes":[{"subj":"T1","pred":"source","obj":"kaiyin_test"},{"subj":"T2","pred":"source","obj":"kaiyin_test"},{"subj":"T3","pred":"source","obj":"kaiyin_test"},{"subj":"T4","pred":"source","obj":"kaiyin_test"},{"subj":"T5","pred":"source","obj":"kaiyin_test"},{"subj":"T33","pred":"source","obj":"kaiyin_test"},{"subj":"T34","pred":"source","obj":"kaiyin_test"}]},{"project":"name_no","denotations":[{"id":"T1","span":{"begin":0,"end":9},"obj":"Var"},{"id":"T2","span":{"begin":13,"end":18},"obj":"Gene"},{"id":"T3","span":{"begin":19,"end":30},"obj":"Enzyme"},{"id":"T4","span":{"begin":42,"end":57},"obj":"PosReg"},{"id":"T5","span":{"begin":65,"end":83},"obj":"MPA"},{"id":"T33","span":{"begin":108,"end":123},"obj":"Disease"},{"id":"T34","span":{"begin":138,"end":170},"obj":"Disease"}],"relations":[{"id":"R1","pred":"ThemeOf","subj":"T3","obj":"T2"},{"id":"R2","pred":"ThemeOf","subj":"T2","obj":"T1"},{"id":"R3","pred":"CauseOf","subj":"T1","obj":"T4"},{"id":"R4","pred":"ThemeOf","subj":"T5","obj":"T4"}],"attributes":[{"subj":"T1","pred":"source","obj":"name_no"},{"subj":"T2","pred":"source","obj":"name_no"},{"subj":"T3","pred":"source","obj":"name_no"},{"subj":"T4","pred":"source","obj":"name_no"},{"subj":"T5","pred":"source","obj":"name_no"},{"subj":"T33","pred":"source","obj":"name_no"},{"subj":"T34","pred":"source","obj":"name_no"}]},{"project":"mondo_disease","denotations":[{"id":"T2","span":{"begin":114,"end":123},"obj":"Disease"},{"id":"T3","span":{"begin":138,"end":170},"obj":"Disease"},{"id":"T4","span":{"begin":198,"end":214},"obj":"Disease"}],"attributes":[{"id":"A2","pred":"mondo_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/MONDO_0005059"},{"id":"A3","pred":"mondo_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/MONDO_0011908"},{"id":"A4","pred":"mondo_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/MONDO_0000605"},{"id":"A5","pred":"mondo_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/MONDO_0005271"},{"subj":"T2","pred":"source","obj":"mondo_disease"},{"subj":"T3","pred":"source","obj":"mondo_disease"},{"subj":"T4","pred":"source","obj":"mondo_disease"}]},{"project":"HP-phenotype","denotations":[{"id":"T2","span":{"begin":138,"end":170},"obj":"Phenotype"},{"id":"T3","span":{"begin":198,"end":214},"obj":"Phenotype"}],"attributes":[{"id":"A2","pred":"hp_id","subj":"T2","obj":"HP:0012209"},{"id":"A3","pred":"hp_id","subj":"T3","obj":"HP:0041092"},{"subj":"T2","pred":"source","obj":"HP-phenotype"},{"subj":"T3","pred":"source","obj":"HP-phenotype"}],"namespaces":[{"prefix":"HP","uri":"http://purl.obolibrary.org/obo/HP_"}]},{"project":"NCBITAXON","denotations":[{"id":"T1","span":{"begin":108,"end":113},"obj":"OrganismTaxon"}],"attributes":[{"id":"A1","pred":"db_id","subj":"T1","obj":"9606"},{"subj":"T1","pred":"source","obj":"NCBITAXON"}]},{"project":"Anatomy-UBERON","denotations":[{"id":"T1","span":{"begin":138,"end":146},"obj":"Body_part"},{"id":"T2","span":{"begin":218,"end":242},"obj":"Body_part"},{"id":"T3","span":{"begin":246,"end":257},"obj":"Body_part"},{"id":"T4","span":{"begin":258,"end":268},"obj":"Body_part"}],"attributes":[{"id":"A1","pred":"uberon_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/UBERON_0007021"},{"id":"A2","pred":"uberon_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/CL_0000839"},{"id":"A3","pred":"uberon_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/CL_0000094"},{"id":"A4","pred":"uberon_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/CL_0000235"},{"subj":"T1","pred":"source","obj":"Anatomy-UBERON"},{"subj":"T2","pred":"source","obj":"Anatomy-UBERON"},{"subj":"T3","pred":"source","obj":"Anatomy-UBERON"},{"subj":"T4","pred":"source","obj":"Anatomy-UBERON"}]},{"project":"CL-cell","denotations":[{"id":"T1","span":{"begin":218,"end":242},"obj":"Cell"},{"id":"T2","span":{"begin":246,"end":257},"obj":"Cell"},{"id":"T3","span":{"begin":258,"end":268},"obj":"Cell"}],"attributes":[{"id":"A1","pred":"cl_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/CL:0000839"},{"id":"A2","pred":"cl_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/CL:0000094"},{"id":"A3","pred":"cl_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/CL:0000235"},{"id":"A4","pred":"cl_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/CL:0000394"},{"subj":"T1","pred":"source","obj":"CL-cell"},{"subj":"T2","pred":"source","obj":"CL-cell"},{"subj":"T3","pred":"source","obj":"CL-cell"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"sonoma2","color":"#ecc393","default":true},{"id":"sonoma","color":"#a993ec"},{"id":"sentences","color":"#96ec93"},{"id":"PubmedHPO","color":"#ec93b0"},{"id":"DisGeNET5_gene_disease","color":"#93caec"},{"id":"kaiyin_test","color":"#e4ec93"},{"id":"name_no","color":"#da93ec"},{"id":"mondo_disease","color":"#93ecc0"},{"id":"HP-phenotype","color":"#eca693"},{"id":"NCBITAXON","color":"#939aec"},{"id":"Anatomy-UBERON","color":"#b4ec93"},{"id":"CL-cell","color":"#ec93ce"}]}]}}