PMC:7600245 / 95332-96916 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7600245","sourcedb":"PMC","sourceid":"7600245","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7600245","text":"Table 2 Most frequently evaluated anti-inflammatory/immunomodulatory drugs in clinical trials for COVID-19 a.\nTherapy Type Mechanism No. of Interventional Clinical Trials b\nTocilizumab(Actemra) Humanized monoclonal antibody IL-6 receptor blocker ~41\nRuxolitinib(Jakafi) Small molecule JAK 1 and 2 inhibitor ~15\nColchicine(Colcrys) Small molecule Inhibition of NLRP3 inflammasome and of microtubule polymerization ~15\nAnakinra(Kineret) Recombinant non-glycosylated human polypeptide IL-1 receptor antagonist ~13\nMethylprednisolone (DEPOMedrol) Small molecule Intracellular receptor-mediated gene expression \u0026 suppression of migration of polymorphonuclear leukocytes, among others ~13\nBaricitinib(Olumiant) Small molecule JAK 1 and 2 inhibitor ~12\nSarilumab(Kevzara) Human monoclonal antibody IL-6 receptor blocker ~10\nDexamethasone(Decadron, Active Injection D) Small molecule Stimulation of glucocorticoid receptors, suppression of neutrophil migration, suppression of inflammatory mediators production, and reversal of increased capillary permeability ~10\nSirolimus(Rapamune) Small molecule mTOR pathway inhibitor ~4\nMavrilimumab Human monoclonal antibody GM-CSF receptor blocker ~4\nSiltuximab(Sylvant) Chimeric monoclonal antibody Anti-IL-6 ~2\nCanakinumab(Ilaris) Human monoclonal antibody Anti-IL-1β ~2\na From clinicaltrials.gov, b No. is as of July 25, 2020. 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