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LitCovid-sample-PD-NCBITaxon

{"project":"LitCovid-sample-PD-NCBITaxon","denotations":[{"id":"T367","span":{"begin":73,"end":83},"obj":"Species"},{"id":"T368","span":{"begin":73,"end":77},"obj":"Species"}],"attributes":[{"id":"A367","pred":"ncbi_taxonomy_id","subj":"T367","obj":"NCBItxid:2697049"},{"id":"A368","pred":"ncbi_taxonomy_id","subj":"T368","obj":"NCBItxid:694009"}],"namespaces":[{"prefix":"NCBItxid","uri":"http://purl.bioontology.org/ontology/NCBITAXON/"}],"text":"Another proposed mechanism that triggers the proinflammatory response to SARS-CoV-2 is ACE/ACE2 imbalance in the RAAS system. It has been speculated that when ACE2 is occupied by the virus, its effects in limiting the amount and activity of Ang-II is decreased; Ang-II is consequently increased and it has been reported to induce a proinflammatory effect via the AT1R receptor (Marchesi et al., 2008; Eguchi et al., 2018). The Ang-II/AT1R system activates disintegrin and the metalloprotease ADAM 17 (also known as TNFα cleavage enzyme TACE), which lead to the intracellular production of epidermal growth factor ligands (EGFR) and TNFα production, with subsequent stimulation of the transcription factor NF-K B, a pivotal player in proinflammatory cytokines release. Additionally, ADAM 17 activation induces the production of the soluble form of IL-6Rα, active on IL-6-STAT3 pathway, which in turn amplifies NF-K B signaling (Murakami et al., 2019; Takimoto-Ohnishi and Murakami, 2019; Palau et al., 2020). The convergence on hyperactivation of NF-K B seems to be crucial in inducing the cytokine storm. The mechanism is self-feeding, given that NF-K B induces the expression of the angiotensinogen gene, amplifying the Ang-II inflammatory response (Costanzo et al., 2003; Hirano and Murakami, 2020)."}

LitCovid-sample-sentences

{"project":"LitCovid-sample-sentences","denotations":[{"id":"T383","span":{"begin":0,"end":125},"obj":"Sentence"},{"id":"T384","span":{"begin":126,"end":422},"obj":"Sentence"},{"id":"T385","span":{"begin":423,"end":767},"obj":"Sentence"},{"id":"T386","span":{"begin":768,"end":1007},"obj":"Sentence"},{"id":"T387","span":{"begin":1008,"end":1104},"obj":"Sentence"},{"id":"T388","span":{"begin":1105,"end":1301},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Another proposed mechanism that triggers the proinflammatory response to SARS-CoV-2 is ACE/ACE2 imbalance in the RAAS system. It has been speculated that when ACE2 is occupied by the virus, its effects in limiting the amount and activity of Ang-II is decreased; Ang-II is consequently increased and it has been reported to induce a proinflammatory effect via the AT1R receptor (Marchesi et al., 2008; Eguchi et al., 2018). The Ang-II/AT1R system activates disintegrin and the metalloprotease ADAM 17 (also known as TNFα cleavage enzyme TACE), which lead to the intracellular production of epidermal growth factor ligands (EGFR) and TNFα production, with subsequent stimulation of the transcription factor NF-K B, a pivotal player in proinflammatory cytokines release. Additionally, ADAM 17 activation induces the production of the soluble form of IL-6Rα, active on IL-6-STAT3 pathway, which in turn amplifies NF-K B signaling (Murakami et al., 2019; Takimoto-Ohnishi and Murakami, 2019; Palau et al., 2020). The convergence on hyperactivation of NF-K B seems to be crucial in inducing the cytokine storm. The mechanism is self-feeding, given that NF-K B induces the expression of the angiotensinogen gene, amplifying the Ang-II inflammatory response (Costanzo et al., 2003; Hirano and Murakami, 2020)."}

LitCovid-sample-Pubtator

{"project":"LitCovid-sample-Pubtator","denotations":[{"id":"1771","span":{"begin":87,"end":90},"obj":"Gene"},{"id":"1772","span":{"begin":91,"end":95},"obj":"Gene"},{"id":"1773","span":{"begin":159,"end":163},"obj":"Gene"},{"id":"1774","span":{"begin":434,"end":438},"obj":"Gene"},{"id":"1775","span":{"begin":492,"end":499},"obj":"Gene"},{"id":"1776","span":{"begin":515,"end":519},"obj":"Gene"},{"id":"1777","span":{"begin":536,"end":540},"obj":"Gene"},{"id":"1778","span":{"begin":622,"end":626},"obj":"Gene"},{"id":"1779","span":{"begin":632,"end":636},"obj":"Gene"},{"id":"1780","span":{"begin":782,"end":789},"obj":"Gene"},{"id":"1781","span":{"begin":847,"end":853},"obj":"Gene"},{"id":"1782","span":{"begin":865,"end":869},"obj":"Gene"},{"id":"1783","span":{"begin":870,"end":875},"obj":"Gene"},{"id":"1784","span":{"begin":1184,"end":1199},"obj":"Gene"},{"id":"1785","span":{"begin":73,"end":83},"obj":"Species"}],"attributes":[{"id":"A1782","pred":"pubann:denotes","subj":"1782","obj":"Gene:3569"},{"id":"A1776","pred":"pubann:denotes","subj":"1776","obj":"Gene:7124"},{"id":"A1784","pred":"pubann:denotes","subj":"1784","obj":"Gene:183"},{"id":"A1773","pred":"pubann:denotes","subj":"1773","obj":"Gene:59272"},{"id":"A1771","pred":"pubann:denotes","subj":"1771","obj":"Gene:1636"},{"id":"A1774","pred":"pubann:denotes","subj":"1774","obj":"Gene:185"},{"id":"A1778","pred":"pubann:denotes","subj":"1778","obj":"Gene:1956"},{"id":"A1772","pred":"pubann:denotes","subj":"1772","obj":"Gene:59272"},{"id":"A1779","pred":"pubann:denotes","subj":"1779","obj":"Gene:7124"},{"id":"A1777","pred":"pubann:denotes","subj":"1777","obj":"Gene:6868"},{"id":"A1783","pred":"pubann:denotes","subj":"1783","obj":"Gene:6774"},{"id":"A1775","pred":"pubann:denotes","subj":"1775","obj":"Gene:6868"},{"id":"A1780","pred":"pubann:denotes","subj":"1780","obj":"Gene:6868"},{"id":"A1781","pred":"pubann:denotes","subj":"1781","obj":"Gene:3570"},{"id":"A1785","pred":"pubann:denotes","subj":"1785","obj":"Tax:2697049"}],"text":"Another proposed mechanism that triggers the proinflammatory response to SARS-CoV-2 is ACE/ACE2 imbalance in the RAAS system. It has been speculated that when ACE2 is occupied by the virus, its effects in limiting the amount and activity of Ang-II is decreased; Ang-II is consequently increased and it has been reported to induce a proinflammatory effect via the AT1R receptor (Marchesi et al., 2008; Eguchi et al., 2018). The Ang-II/AT1R system activates disintegrin and the metalloprotease ADAM 17 (also known as TNFα cleavage enzyme TACE), which lead to the intracellular production of epidermal growth factor ligands (EGFR) and TNFα production, with subsequent stimulation of the transcription factor NF-K B, a pivotal player in proinflammatory cytokines release. Additionally, ADAM 17 activation induces the production of the soluble form of IL-6Rα, active on IL-6-STAT3 pathway, which in turn amplifies NF-K B signaling (Murakami et al., 2019; Takimoto-Ohnishi and Murakami, 2019; Palau et al., 2020). The convergence on hyperactivation of NF-K B seems to be crucial in inducing the cytokine storm. The mechanism is self-feeding, given that NF-K B induces the expression of the angiotensinogen gene, amplifying the Ang-II inflammatory response (Costanzo et al., 2003; Hirano and Murakami, 2020)."}

LitCovid-sample-UniProt

LitCovid-sample-PD-IDO

{"project":"LitCovid-sample-PD-IDO","denotations":[{"id":"T258","span":{"begin":183,"end":188},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T259","span":{"begin":575,"end":585},"obj":"http://purl.obolibrary.org/obo/IDO_0000607"},{"id":"T260","span":{"begin":599,"end":605},"obj":"http://purl.obolibrary.org/obo/GO_0040007"},{"id":"T261","span":{"begin":637,"end":647},"obj":"http://purl.obolibrary.org/obo/IDO_0000607"},{"id":"T262","span":{"begin":813,"end":823},"obj":"http://purl.obolibrary.org/obo/IDO_0000607"}],"text":"Another proposed mechanism that triggers the proinflammatory response to SARS-CoV-2 is ACE/ACE2 imbalance in the RAAS system. It has been speculated that when ACE2 is occupied by the virus, its effects in limiting the amount and activity of Ang-II is decreased; Ang-II is consequently increased and it has been reported to induce a proinflammatory effect via the AT1R receptor (Marchesi et al., 2008; Eguchi et al., 2018). The Ang-II/AT1R system activates disintegrin and the metalloprotease ADAM 17 (also known as TNFα cleavage enzyme TACE), which lead to the intracellular production of epidermal growth factor ligands (EGFR) and TNFα production, with subsequent stimulation of the transcription factor NF-K B, a pivotal player in proinflammatory cytokines release. Additionally, ADAM 17 activation induces the production of the soluble form of IL-6Rα, active on IL-6-STAT3 pathway, which in turn amplifies NF-K B signaling (Murakami et al., 2019; Takimoto-Ohnishi and Murakami, 2019; Palau et al., 2020). The convergence on hyperactivation of NF-K B seems to be crucial in inducing the cytokine storm. The mechanism is self-feeding, given that NF-K B induces the expression of the angiotensinogen gene, amplifying the Ang-II inflammatory response (Costanzo et al., 2003; Hirano and Murakami, 2020)."}

LitCovid-sample-PD-FMA

{"project":"LitCovid-sample-PD-FMA","denotations":[{"id":"T436","span":{"begin":749,"end":758},"obj":"Body_part"},{"id":"T437","span":{"begin":1089,"end":1097},"obj":"Body_part"},{"id":"T438","span":{"begin":1200,"end":1204},"obj":"Body_part"}],"attributes":[{"id":"A436","pred":"fma_id","subj":"T436","obj":"http://purl.org/sig/ont/fma/fma84050"},{"id":"A437","pred":"fma_id","subj":"T437","obj":"http://purl.org/sig/ont/fma/fma84050"},{"id":"A438","pred":"fma_id","subj":"T438","obj":"http://purl.org/sig/ont/fma/fma74402"}],"text":"Another proposed mechanism that triggers the proinflammatory response to SARS-CoV-2 is ACE/ACE2 imbalance in the RAAS system. It has been speculated that when ACE2 is occupied by the virus, its effects in limiting the amount and activity of Ang-II is decreased; Ang-II is consequently increased and it has been reported to induce a proinflammatory effect via the AT1R receptor (Marchesi et al., 2008; Eguchi et al., 2018). The Ang-II/AT1R system activates disintegrin and the metalloprotease ADAM 17 (also known as TNFα cleavage enzyme TACE), which lead to the intracellular production of epidermal growth factor ligands (EGFR) and TNFα production, with subsequent stimulation of the transcription factor NF-K B, a pivotal player in proinflammatory cytokines release. Additionally, ADAM 17 activation induces the production of the soluble form of IL-6Rα, active on IL-6-STAT3 pathway, which in turn amplifies NF-K B signaling (Murakami et al., 2019; Takimoto-Ohnishi and Murakami, 2019; Palau et al., 2020). The convergence on hyperactivation of NF-K B seems to be crucial in inducing the cytokine storm. The mechanism is self-feeding, given that NF-K B induces the expression of the angiotensinogen gene, amplifying the Ang-II inflammatory response (Costanzo et al., 2003; Hirano and Murakami, 2020)."}

LitCovid-sample-PD-MONDO

{"project":"LitCovid-sample-PD-MONDO","denotations":[{"id":"T381","span":{"begin":73,"end":83},"obj":"Disease"},{"id":"T382","span":{"begin":73,"end":77},"obj":"Disease"}],"attributes":[{"id":"A381","pred":"mondo_id","subj":"T381","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A382","pred":"mondo_id","subj":"T382","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"}],"text":"Another proposed mechanism that triggers the proinflammatory response to SARS-CoV-2 is ACE/ACE2 imbalance in the RAAS system. It has been speculated that when ACE2 is occupied by the virus, its effects in limiting the amount and activity of Ang-II is decreased; Ang-II is consequently increased and it has been reported to induce a proinflammatory effect via the AT1R receptor (Marchesi et al., 2008; Eguchi et al., 2018). The Ang-II/AT1R system activates disintegrin and the metalloprotease ADAM 17 (also known as TNFα cleavage enzyme TACE), which lead to the intracellular production of epidermal growth factor ligands (EGFR) and TNFα production, with subsequent stimulation of the transcription factor NF-K B, a pivotal player in proinflammatory cytokines release. Additionally, ADAM 17 activation induces the production of the soluble form of IL-6Rα, active on IL-6-STAT3 pathway, which in turn amplifies NF-K B signaling (Murakami et al., 2019; Takimoto-Ohnishi and Murakami, 2019; Palau et al., 2020). The convergence on hyperactivation of NF-K B seems to be crucial in inducing the cytokine storm. The mechanism is self-feeding, given that NF-K B induces the expression of the angiotensinogen gene, amplifying the Ang-II inflammatory response (Costanzo et al., 2003; Hirano and Murakami, 2020)."}

LitCovid-sample-PD-GO-BP-0

{"project":"LitCovid-sample-PD-GO-BP-0","denotations":[{"id":"T132","span":{"begin":599,"end":605},"obj":"http://purl.obolibrary.org/obo/GO_0040007"},{"id":"T133","span":{"begin":622,"end":626},"obj":"http://purl.obolibrary.org/obo/GO_0005006"},{"id":"T134","span":{"begin":684,"end":697},"obj":"http://purl.obolibrary.org/obo/GO_0006351"},{"id":"T135","span":{"begin":847,"end":852},"obj":"http://purl.obolibrary.org/obo/GO_0004915"},{"id":"T136","span":{"begin":916,"end":925},"obj":"http://purl.obolibrary.org/obo/GO_0023052"},{"id":"T137","span":{"begin":1228,"end":1249},"obj":"http://purl.obolibrary.org/obo/GO_0006954"}],"text":"Another proposed mechanism that triggers the proinflammatory response to SARS-CoV-2 is ACE/ACE2 imbalance in the RAAS system. It has been speculated that when ACE2 is occupied by the virus, its effects in limiting the amount and activity of Ang-II is decreased; Ang-II is consequently increased and it has been reported to induce a proinflammatory effect via the AT1R receptor (Marchesi et al., 2008; Eguchi et al., 2018). The Ang-II/AT1R system activates disintegrin and the metalloprotease ADAM 17 (also known as TNFα cleavage enzyme TACE), which lead to the intracellular production of epidermal growth factor ligands (EGFR) and TNFα production, with subsequent stimulation of the transcription factor NF-K B, a pivotal player in proinflammatory cytokines release. Additionally, ADAM 17 activation induces the production of the soluble form of IL-6Rα, active on IL-6-STAT3 pathway, which in turn amplifies NF-K B signaling (Murakami et al., 2019; Takimoto-Ohnishi and Murakami, 2019; Palau et al., 2020). The convergence on hyperactivation of NF-K B seems to be crucial in inducing the cytokine storm. The mechanism is self-feeding, given that NF-K B induces the expression of the angiotensinogen gene, amplifying the Ang-II inflammatory response (Costanzo et al., 2003; Hirano and Murakami, 2020)."}

LitCovid-sample-PD-HP

{"project":"LitCovid-sample-PD-HP","denotations":[{"id":"T69","span":{"begin":1089,"end":1103},"obj":"Phenotype"}],"attributes":[{"id":"A69","pred":"hp_id","subj":"T69","obj":"http://purl.obolibrary.org/obo/HP_0033041"}],"text":"Another proposed mechanism that triggers the proinflammatory response to SARS-CoV-2 is ACE/ACE2 imbalance in the RAAS system. It has been speculated that when ACE2 is occupied by the virus, its effects in limiting the amount and activity of Ang-II is decreased; Ang-II is consequently increased and it has been reported to induce a proinflammatory effect via the AT1R receptor (Marchesi et al., 2008; Eguchi et al., 2018). The Ang-II/AT1R system activates disintegrin and the metalloprotease ADAM 17 (also known as TNFα cleavage enzyme TACE), which lead to the intracellular production of epidermal growth factor ligands (EGFR) and TNFα production, with subsequent stimulation of the transcription factor NF-K B, a pivotal player in proinflammatory cytokines release. Additionally, ADAM 17 activation induces the production of the soluble form of IL-6Rα, active on IL-6-STAT3 pathway, which in turn amplifies NF-K B signaling (Murakami et al., 2019; Takimoto-Ohnishi and Murakami, 2019; Palau et al., 2020). The convergence on hyperactivation of NF-K B seems to be crucial in inducing the cytokine storm. The mechanism is self-feeding, given that NF-K B induces the expression of the angiotensinogen gene, amplifying the Ang-II inflammatory response (Costanzo et al., 2003; Hirano and Murakami, 2020)."}

LitCovid-sample-GO-BP

{"project":"LitCovid-sample-GO-BP","denotations":[{"id":"T136","span":{"begin":599,"end":605},"obj":"http://purl.obolibrary.org/obo/GO_0040007"},{"id":"T137","span":{"begin":622,"end":626},"obj":"http://purl.obolibrary.org/obo/GO_0005006"},{"id":"T138","span":{"begin":684,"end":704},"obj":"http://purl.obolibrary.org/obo/GO_0000981"},{"id":"T139","span":{"begin":684,"end":697},"obj":"http://purl.obolibrary.org/obo/GO_0006351"},{"id":"T140","span":{"begin":847,"end":852},"obj":"http://purl.obolibrary.org/obo/GO_0004915"},{"id":"T141","span":{"begin":916,"end":925},"obj":"http://purl.obolibrary.org/obo/GO_0023052"},{"id":"T142","span":{"begin":1228,"end":1249},"obj":"http://purl.obolibrary.org/obo/GO_0006954"}],"text":"Another proposed mechanism that triggers the proinflammatory response to SARS-CoV-2 is ACE/ACE2 imbalance in the RAAS system. It has been speculated that when ACE2 is occupied by the virus, its effects in limiting the amount and activity of Ang-II is decreased; Ang-II is consequently increased and it has been reported to induce a proinflammatory effect via the AT1R receptor (Marchesi et al., 2008; Eguchi et al., 2018). The Ang-II/AT1R system activates disintegrin and the metalloprotease ADAM 17 (also known as TNFα cleavage enzyme TACE), which lead to the intracellular production of epidermal growth factor ligands (EGFR) and TNFα production, with subsequent stimulation of the transcription factor NF-K B, a pivotal player in proinflammatory cytokines release. Additionally, ADAM 17 activation induces the production of the soluble form of IL-6Rα, active on IL-6-STAT3 pathway, which in turn amplifies NF-K B signaling (Murakami et al., 2019; Takimoto-Ohnishi and Murakami, 2019; Palau et al., 2020). The convergence on hyperactivation of NF-K B seems to be crucial in inducing the cytokine storm. The mechanism is self-feeding, given that NF-K B induces the expression of the angiotensinogen gene, amplifying the Ang-II inflammatory response (Costanzo et al., 2003; Hirano and Murakami, 2020)."}

LitCovid-PD-HP

{"project":"LitCovid-PD-HP","denotations":[{"id":"T72","span":{"begin":1089,"end":1103},"obj":"Phenotype"}],"attributes":[{"id":"A72","pred":"hp_id","subj":"T72","obj":"http://purl.obolibrary.org/obo/HP_0033041"}],"text":"Another proposed mechanism that triggers the proinflammatory response to SARS-CoV-2 is ACE/ACE2 imbalance in the RAAS system. It has been speculated that when ACE2 is occupied by the virus, its effects in limiting the amount and activity of Ang-II is decreased; Ang-II is consequently increased and it has been reported to induce a proinflammatory effect via the AT1R receptor (Marchesi et al., 2008; Eguchi et al., 2018). The Ang-II/AT1R system activates disintegrin and the metalloprotease ADAM 17 (also known as TNFα cleavage enzyme TACE), which lead to the intracellular production of epidermal growth factor ligands (EGFR) and TNFα production, with subsequent stimulation of the transcription factor NF-K B, a pivotal player in proinflammatory cytokines release. Additionally, ADAM 17 activation induces the production of the soluble form of IL-6Rα, active on IL-6-STAT3 pathway, which in turn amplifies NF-K B signaling (Murakami et al., 2019; Takimoto-Ohnishi and Murakami, 2019; Palau et al., 2020). The convergence on hyperactivation of NF-K B seems to be crucial in inducing the cytokine storm. The mechanism is self-feeding, given that NF-K B induces the expression of the angiotensinogen gene, amplifying the Ang-II inflammatory response (Costanzo et al., 2003; Hirano and Murakami, 2020)."}

LitCovid-PubTator

{"project":"LitCovid-PubTator","denotations":[{"id":"1771","span":{"begin":87,"end":90},"obj":"Gene"},{"id":"1772","span":{"begin":91,"end":95},"obj":"Gene"},{"id":"1773","span":{"begin":159,"end":163},"obj":"Gene"},{"id":"1774","span":{"begin":434,"end":438},"obj":"Gene"},{"id":"1775","span":{"begin":492,"end":499},"obj":"Gene"},{"id":"1776","span":{"begin":515,"end":519},"obj":"Gene"},{"id":"1777","span":{"begin":536,"end":540},"obj":"Gene"},{"id":"1778","span":{"begin":622,"end":626},"obj":"Gene"},{"id":"1779","span":{"begin":632,"end":636},"obj":"Gene"},{"id":"1780","span":{"begin":782,"end":789},"obj":"Gene"},{"id":"1781","span":{"begin":847,"end":853},"obj":"Gene"},{"id":"1782","span":{"begin":865,"end":869},"obj":"Gene"},{"id":"1783","span":{"begin":870,"end":875},"obj":"Gene"},{"id":"1784","span":{"begin":1184,"end":1199},"obj":"Gene"},{"id":"1785","span":{"begin":73,"end":83},"obj":"Species"}],"attributes":[{"id":"A1771","pred":"tao:has_database_id","subj":"1771","obj":"Gene:1636"},{"id":"A1772","pred":"tao:has_database_id","subj":"1772","obj":"Gene:59272"},{"id":"A1773","pred":"tao:has_database_id","subj":"1773","obj":"Gene:59272"},{"id":"A1774","pred":"tao:has_database_id","subj":"1774","obj":"Gene:185"},{"id":"A1775","pred":"tao:has_database_id","subj":"1775","obj":"Gene:6868"},{"id":"A1776","pred":"tao:has_database_id","subj":"1776","obj":"Gene:7124"},{"id":"A1777","pred":"tao:has_database_id","subj":"1777","obj":"Gene:6868"},{"id":"A1778","pred":"tao:has_database_id","subj":"1778","obj":"Gene:1956"},{"id":"A1779","pred":"tao:has_database_id","subj":"1779","obj":"Gene:7124"},{"id":"A1780","pred":"tao:has_database_id","subj":"1780","obj":"Gene:6868"},{"id":"A1781","pred":"tao:has_database_id","subj":"1781","obj":"Gene:3570"},{"id":"A1782","pred":"tao:has_database_id","subj":"1782","obj":"Gene:3569"},{"id":"A1783","pred":"tao:has_database_id","subj":"1783","obj":"Gene:6774"},{"id":"A1784","pred":"tao:has_database_id","subj":"1784","obj":"Gene:183"},{"id":"A1785","pred":"tao:has_database_id","subj":"1785","obj":"Tax:2697049"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Another proposed mechanism that triggers the proinflammatory response to SARS-CoV-2 is ACE/ACE2 imbalance in the RAAS system. It has been speculated that when ACE2 is occupied by the virus, its effects in limiting the amount and activity of Ang-II is decreased; Ang-II is consequently increased and it has been reported to induce a proinflammatory effect via the AT1R receptor (Marchesi et al., 2008; Eguchi et al., 2018). The Ang-II/AT1R system activates disintegrin and the metalloprotease ADAM 17 (also known as TNFα cleavage enzyme TACE), which lead to the intracellular production of epidermal growth factor ligands (EGFR) and TNFα production, with subsequent stimulation of the transcription factor NF-K B, a pivotal player in proinflammatory cytokines release. Additionally, ADAM 17 activation induces the production of the soluble form of IL-6Rα, active on IL-6-STAT3 pathway, which in turn amplifies NF-K B signaling (Murakami et al., 2019; Takimoto-Ohnishi and Murakami, 2019; Palau et al., 2020). The convergence on hyperactivation of NF-K B seems to be crucial in inducing the cytokine storm. The mechanism is self-feeding, given that NF-K B induces the expression of the angiotensinogen gene, amplifying the Ang-II inflammatory response (Costanzo et al., 2003; Hirano and Murakami, 2020)."}

LitCovid-sentences

{"project":"LitCovid-sentences","denotations":[{"id":"T383","span":{"begin":0,"end":125},"obj":"Sentence"},{"id":"T384","span":{"begin":126,"end":422},"obj":"Sentence"},{"id":"T385","span":{"begin":423,"end":767},"obj":"Sentence"},{"id":"T386","span":{"begin":768,"end":1007},"obj":"Sentence"},{"id":"T387","span":{"begin":1008,"end":1104},"obj":"Sentence"},{"id":"T388","span":{"begin":1105,"end":1301},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Another proposed mechanism that triggers the proinflammatory response to SARS-CoV-2 is ACE/ACE2 imbalance in the RAAS system. It has been speculated that when ACE2 is occupied by the virus, its effects in limiting the amount and activity of Ang-II is decreased; Ang-II is consequently increased and it has been reported to induce a proinflammatory effect via the AT1R receptor (Marchesi et al., 2008; Eguchi et al., 2018). The Ang-II/AT1R system activates disintegrin and the metalloprotease ADAM 17 (also known as TNFα cleavage enzyme TACE), which lead to the intracellular production of epidermal growth factor ligands (EGFR) and TNFα production, with subsequent stimulation of the transcription factor NF-K B, a pivotal player in proinflammatory cytokines release. Additionally, ADAM 17 activation induces the production of the soluble form of IL-6Rα, active on IL-6-STAT3 pathway, which in turn amplifies NF-K B signaling (Murakami et al., 2019; Takimoto-Ohnishi and Murakami, 2019; Palau et al., 2020). The convergence on hyperactivation of NF-K B seems to be crucial in inducing the cytokine storm. The mechanism is self-feeding, given that NF-K B induces the expression of the angiotensinogen gene, amplifying the Ang-II inflammatory response (Costanzo et al., 2003; Hirano and Murakami, 2020)."}

PMC:7556165 / 64229-65530 JSONTXT

Annnotations TAB JSON ListView MergeView

PMC:7556165 / 64229-65530 JSON TXT