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PMC:7556165 / 64229-65530 JSON TXT

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LitCovid-sample-PD-NCBITaxon

Id	Subject	Object	Predicate	Lexical cue	ncbi_taxonomy_id
T367	73-83	Species	denotes	SARS-CoV-2	NCBItxid:2697049
T368	73-77	Species	denotes	SARS	NCBItxid:694009

LitCovid-sample-sentences

Id	Subject	Object	Predicate	Lexical cue
T383	0-125	Sentence	denotes	Another proposed mechanism that triggers the proinflammatory response to SARS-CoV-2 is ACE/ACE2 imbalance in the RAAS system.
T384	126-422	Sentence	denotes	It has been speculated that when ACE2 is occupied by the virus, its effects in limiting the amount and activity of Ang-II is decreased; Ang-II is consequently increased and it has been reported to induce a proinflammatory effect via the AT1R receptor (Marchesi et al., 2008; Eguchi et al., 2018).
T385	423-767	Sentence	denotes	The Ang-II/AT1R system activates disintegrin and the metalloprotease ADAM 17 (also known as TNFα cleavage enzyme TACE), which lead to the intracellular production of epidermal growth factor ligands (EGFR) and TNFα production, with subsequent stimulation of the transcription factor NF-K B, a pivotal player in proinflammatory cytokines release.
T386	768-1007	Sentence	denotes	Additionally, ADAM 17 activation induces the production of the soluble form of IL-6Rα, active on IL-6-STAT3 pathway, which in turn amplifies NF-K B signaling (Murakami et al., 2019; Takimoto-Ohnishi and Murakami, 2019; Palau et al., 2020).
T387	1008-1104	Sentence	denotes	The convergence on hyperactivation of NF-K B seems to be crucial in inducing the cytokine storm.
T388	1105-1301	Sentence	denotes	The mechanism is self-feeding, given that NF-K B induces the expression of the angiotensinogen gene, amplifying the Ang-II inflammatory response (Costanzo et al., 2003; Hirano and Murakami, 2020).

LitCovid-sample-Pubtator

Id	Subject	Object	Predicate	Lexical cue	pubann:denotes
1771	87-90	Gene	denotes	ACE	Gene:1636
1772	91-95	Gene	denotes	ACE2	Gene:59272
1773	159-163	Gene	denotes	ACE2	Gene:59272
1774	434-438	Gene	denotes	AT1R	Gene:185
1775	492-499	Gene	denotes	ADAM 17	Gene:6868
1776	515-519	Gene	denotes	TNFα	Gene:7124
1777	536-540	Gene	denotes	TACE	Gene:6868
1778	622-626	Gene	denotes	EGFR	Gene:1956
1779	632-636	Gene	denotes	TNFα	Gene:7124
1780	782-789	Gene	denotes	ADAM 17	Gene:6868
1781	847-853	Gene	denotes	IL-6Rα	Gene:3570
1782	865-869	Gene	denotes	IL-6	Gene:3569
1783	870-875	Gene	denotes	STAT3	Gene:6774
1784	1184-1199	Gene	denotes	angiotensinogen	Gene:183
1785	73-83	Species	denotes	SARS-CoV-2	Tax:2697049

LitCovid-sample-UniProt

Id	Subject	Object	Predicate	Lexical cue	uniprot_id
T5927	87-90	Protein	denotes	ACE	https://www.uniprot.org/uniprot/Q9GLN7\|https://www.uniprot.org/uniprot/Q9GLN6\|https://www.uniprot.org/uniprot/Q9EQM9\|https://www.uniprot.org/uniprot/Q8CFN1\|https://www.uniprot.org/uniprot/Q7TMC6\|https://www.uniprot.org/uniprot/Q7M4L4\|https://www.uniprot.org/uniprot/Q6GTS2\|https://www.uniprot.org/uniprot/Q59GY8\|https://www.uniprot.org/uniprot/Q53YX9\|https://www.uniprot.org/uniprot/Q50JE5\|https://www.uniprot.org/uniprot/Q10751\|https://www.uniprot.org/uniprot/Q0GA41\|https://www.uniprot.org/uniprot/P47820\|https://www.uniprot.org/uniprot/P22968\|https://www.uniprot.org/uniprot/P22967\|https://www.uniprot.org/uniprot/P22966\|https://www.uniprot.org/uniprot/P12822\|https://www.uniprot.org/uniprot/P12821\|https://www.uniprot.org/uniprot/P12820\|https://www.uniprot.org/uniprot/P09470\|https://www.uniprot.org/uniprot/O02852\|https://www.uniprot.org/uniprot/E7EU16\|https://www.uniprot.org/uniprot/B4DXI3\|https://www.uniprot.org/uniprot/B0LPF0\|https://www.uniprot.org/uniprot/Q9VJV3
T5952	91-95	Protein	denotes	ACE2	https://www.uniprot.org/uniprot/Q9UFZ6
T5953	159-163	Protein	denotes	ACE2	https://www.uniprot.org/uniprot/Q9UFZ6
T5954	456-467	Protein	denotes	disintegrin	https://www.uniprot.org/uniprot/Q9YI19\|https://www.uniprot.org/uniprot/Q9PVK9\|https://www.uniprot.org/uniprot/Q9IAX6\|https://www.uniprot.org/uniprot/Q7SZE0\|https://www.uniprot.org/uniprot/Q7SZD7\|https://www.uniprot.org/uniprot/Q7SZD6\|https://www.uniprot.org/uniprot/Q5EE07\|https://www.uniprot.org/uniprot/P0DMH4\|https://www.uniprot.org/uniprot/P0C6E3\|https://www.uniprot.org/uniprot/O73795\|https://www.uniprot.org/uniprot/E9NW26
T5965	492-499	Protein	denotes	ADAM 17	https://www.uniprot.org/uniprot/Q9Z1K9\|https://www.uniprot.org/uniprot/Q9Z0K3\|https://www.uniprot.org/uniprot/Q9Z0F8\|https://www.uniprot.org/uniprot/Q9R1U4\|https://www.uniprot.org/uniprot/Q505A7\|https://www.uniprot.org/uniprot/P78536\|https://www.uniprot.org/uniprot/O88726\|https://www.uniprot.org/uniprot/O77636\|https://www.uniprot.org/uniprot/O60226
T5974	589-612	Protein	denotes	epidermal growth factor	https://www.uniprot.org/uniprot/Q9GU69\|https://www.uniprot.org/uniprot/Q9BEA0\|https://www.uniprot.org/uniprot/Q9BDQ0\|https://www.uniprot.org/uniprot/Q95ND4\|https://www.uniprot.org/uniprot/Q6P9J2\|https://www.uniprot.org/uniprot/Q63183\|https://www.uniprot.org/uniprot/Q569W5\|https://www.uniprot.org/uniprot/Q52LZ6\|https://www.uniprot.org/uniprot/Q00968\|https://www.uniprot.org/uniprot/P07522\|https://www.uniprot.org/uniprot/P01133\|https://www.uniprot.org/uniprot/P01132\|https://www.uniprot.org/uniprot/O62759\|https://www.uniprot.org/uniprot/E9QNX6\|https://www.uniprot.org/uniprot/E9PBF0\|https://www.uniprot.org/uniprot/E7EVD2\|https://www.uniprot.org/uniprot/B4DRK7
T5991	782-789	Protein	denotes	ADAM 17	https://www.uniprot.org/uniprot/Q9Z1K9\|https://www.uniprot.org/uniprot/Q9Z0K3\|https://www.uniprot.org/uniprot/Q9Z0F8\|https://www.uniprot.org/uniprot/Q9R1U4\|https://www.uniprot.org/uniprot/Q505A7\|https://www.uniprot.org/uniprot/P78536\|https://www.uniprot.org/uniprot/O88726\|https://www.uniprot.org/uniprot/O77636\|https://www.uniprot.org/uniprot/O60226
T6000	865-869	Protein	denotes	IL-6	https://www.uniprot.org/uniprot/Q9XT80\|https://www.uniprot.org/uniprot/Q9UCU4\|https://www.uniprot.org/uniprot/Q9UCU3\|https://www.uniprot.org/uniprot/Q9UCU2\|https://www.uniprot.org/uniprot/Q9MZR1\|https://www.uniprot.org/uniprot/Q9MYZ7\|https://www.uniprot.org/uniprot/Q95KN6\|https://www.uniprot.org/uniprot/Q95181\|https://www.uniprot.org/uniprot/Q90YI0\|https://www.uniprot.org/uniprot/Q8MKH0\|https://www.uniprot.org/uniprot/Q8BN26\|https://www.uniprot.org/uniprot/Q865X6\|https://www.uniprot.org/uniprot/Q865W7\|https://www.uniprot.org/uniprot/Q6V919\|https://www.uniprot.org/uniprot/Q6L6X6\|https://www.uniprot.org/uniprot/Q5I6E3\|https://www.uniprot.org/uniprot/Q3UCQ0\|https://www.uniprot.org/uniprot/Q2MH06\|https://www.uniprot.org/uniprot/Q28819\|https://www.uniprot.org/uniprot/Q28747\|https://www.uniprot.org/uniprot/Q28319\|https://www.uniprot.org/uniprot/Q25BC2\|https://www.uniprot.org/uniprot/Q0PW36\|https://www.uniprot.org/uniprot/Q0GGL7\|https://www.uniprot.org/uniprot/Q08DT2\|https://www.uniprot.org/uniprot/P79341\|https://www.uniprot.org/uniprot/P51494\|https://www.uniprot.org/uniprot/P46650\|https://www.uniprot.org/uniprot/P41693\|https://www.uniprot.org/uniprot/P41683\|https://www.uniprot.org/uniprot/P41323\|https://www.uniprot.org/uniprot/P29455\|https://www.uniprot.org/uniprot/P26893\|https://www.uniprot.org/uniprot/P26892\|https://www.uniprot.org/uniprot/P20607\|https://www.uniprot.org/uniprot/P08505\|https://www.uniprot.org/uniprot/P05231\|https://www.uniprot.org/uniprot/O46568\|https://www.uniprot.org/uniprot/O35736\|https://www.uniprot.org/uniprot/O19007\|https://www.uniprot.org/uniprot/B6CKP4\|https://www.uniprot.org/uniprot/A9QWQ9\|https://www.uniprot.org/uniprot/A3FBE9\|https://www.uniprot.org/uniprot/A0S0B0
T6044	1184-1199	Protein	denotes	angiotensinogen	https://www.uniprot.org/uniprot/Q9TSZ0\|https://www.uniprot.org/uniprot/Q9GLP7\|https://www.uniprot.org/uniprot/Q9GLP6\|https://www.uniprot.org/uniprot/Q9GLN8\|https://www.uniprot.org/uniprot/Q96F91\|https://www.uniprot.org/uniprot/Q16359\|https://www.uniprot.org/uniprot/Q16358\|https://www.uniprot.org/uniprot/P67886\|https://www.uniprot.org/uniprot/P67885\|https://www.uniprot.org/uniprot/P20757\|https://www.uniprot.org/uniprot/P11859\|https://www.uniprot.org/uniprot/P01019\|https://www.uniprot.org/uniprot/P01018\|https://www.uniprot.org/uniprot/P01017\|https://www.uniprot.org/uniprot/P01016\|https://www.uniprot.org/uniprot/P01015\|https://www.uniprot.org/uniprot/A0A3Q1LGY9

LitCovid-sample-PD-IDO

Id	Subject	Object	Predicate	Lexical cue
T258	183-188	http://purl.obolibrary.org/obo/NCBITaxon_10239	denotes	virus
T259	575-585	http://purl.obolibrary.org/obo/IDO_0000607	denotes	production
T260	599-605	http://purl.obolibrary.org/obo/GO_0040007	denotes	growth
T261	637-647	http://purl.obolibrary.org/obo/IDO_0000607	denotes	production
T262	813-823	http://purl.obolibrary.org/obo/IDO_0000607	denotes	production

LitCovid-sample-PD-FMA

Id	Subject	Object	Predicate	Lexical cue	fma_id
T436	749-758	Body_part	denotes	cytokines	http://purl.org/sig/ont/fma/fma84050
T437	1089-1097	Body_part	denotes	cytokine	http://purl.org/sig/ont/fma/fma84050
T438	1200-1204	Body_part	denotes	gene	http://purl.org/sig/ont/fma/fma74402

LitCovid-sample-PD-MONDO

Id	Subject	Object	Predicate	Lexical cue	mondo_id
T381	73-83	Disease	denotes	SARS-CoV-2	http://purl.obolibrary.org/obo/MONDO_0100096
T382	73-77	Disease	denotes	SARS	http://purl.obolibrary.org/obo/MONDO_0005091

LitCovid-sample-PD-GO-BP-0

Id	Subject	Object	Predicate	Lexical cue
T132	599-605	http://purl.obolibrary.org/obo/GO_0040007	denotes	growth
T133	622-626	http://purl.obolibrary.org/obo/GO_0005006	denotes	EGFR
T134	684-697	http://purl.obolibrary.org/obo/GO_0006351	denotes	transcription
T135	847-852	http://purl.obolibrary.org/obo/GO_0004915	denotes	IL-6R
T136	916-925	http://purl.obolibrary.org/obo/GO_0023052	denotes	signaling
T137	1228-1249	http://purl.obolibrary.org/obo/GO_0006954	denotes	inflammatory response

LitCovid-sample-PD-HP

Id	Subject	Object	Predicate	Lexical cue	hp_id
T69	1089-1103	Phenotype	denotes	cytokine storm	http://purl.obolibrary.org/obo/HP_0033041

LitCovid-sample-GO-BP

Id	Subject	Object	Predicate	Lexical cue
T136	599-605	http://purl.obolibrary.org/obo/GO_0040007	denotes	growth
T137	622-626	http://purl.obolibrary.org/obo/GO_0005006	denotes	EGFR
T138	684-704	http://purl.obolibrary.org/obo/GO_0000981	denotes	transcription factor
T139	684-697	http://purl.obolibrary.org/obo/GO_0006351	denotes	transcription
T140	847-852	http://purl.obolibrary.org/obo/GO_0004915	denotes	IL-6R
T141	916-925	http://purl.obolibrary.org/obo/GO_0023052	denotes	signaling
T142	1228-1249	http://purl.obolibrary.org/obo/GO_0006954	denotes	inflammatory response

LitCovid-PD-HP

Id	Subject	Object	Predicate	Lexical cue	hp_id
T72	1089-1103	Phenotype	denotes	cytokine storm	http://purl.obolibrary.org/obo/HP_0033041

LitCovid-PubTator

Id	Subject	Object	Predicate	Lexical cue	tao:has_database_id
1771	87-90	Gene	denotes	ACE	Gene:1636
1772	91-95	Gene	denotes	ACE2	Gene:59272
1773	159-163	Gene	denotes	ACE2	Gene:59272
1774	434-438	Gene	denotes	AT1R	Gene:185
1775	492-499	Gene	denotes	ADAM 17	Gene:6868
1776	515-519	Gene	denotes	TNFα	Gene:7124
1777	536-540	Gene	denotes	TACE	Gene:6868
1778	622-626	Gene	denotes	EGFR	Gene:1956
1779	632-636	Gene	denotes	TNFα	Gene:7124
1780	782-789	Gene	denotes	ADAM 17	Gene:6868
1781	847-853	Gene	denotes	IL-6Rα	Gene:3570
1782	865-869	Gene	denotes	IL-6	Gene:3569
1783	870-875	Gene	denotes	STAT3	Gene:6774
1784	1184-1199	Gene	denotes	angiotensinogen	Gene:183
1785	73-83	Species	denotes	SARS-CoV-2	Tax:2697049

LitCovid-sentences

Id	Subject	Object	Predicate	Lexical cue
T383	0-125	Sentence	denotes	Another proposed mechanism that triggers the proinflammatory response to SARS-CoV-2 is ACE/ACE2 imbalance in the RAAS system.
T384	126-422	Sentence	denotes	It has been speculated that when ACE2 is occupied by the virus, its effects in limiting the amount and activity of Ang-II is decreased; Ang-II is consequently increased and it has been reported to induce a proinflammatory effect via the AT1R receptor (Marchesi et al., 2008; Eguchi et al., 2018).
T385	423-767	Sentence	denotes	The Ang-II/AT1R system activates disintegrin and the metalloprotease ADAM 17 (also known as TNFα cleavage enzyme TACE), which lead to the intracellular production of epidermal growth factor ligands (EGFR) and TNFα production, with subsequent stimulation of the transcription factor NF-K B, a pivotal player in proinflammatory cytokines release.
T386	768-1007	Sentence	denotes	Additionally, ADAM 17 activation induces the production of the soluble form of IL-6Rα, active on IL-6-STAT3 pathway, which in turn amplifies NF-K B signaling (Murakami et al., 2019; Takimoto-Ohnishi and Murakami, 2019; Palau et al., 2020).
T387	1008-1104	Sentence	denotes	The convergence on hyperactivation of NF-K B seems to be crucial in inducing the cytokine storm.
T388	1105-1301	Sentence	denotes	The mechanism is self-feeding, given that NF-K B induces the expression of the angiotensinogen gene, amplifying the Ang-II inflammatory response (Costanzo et al., 2003; Hirano and Murakami, 2020).