PMC:7556165 / 64229-65530 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7556165","sourcedb":"PMC","sourceid":"7556165","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7556165","text":"Another proposed mechanism that triggers the proinflammatory response to SARS-CoV-2 is ACE/ACE2 imbalance in the RAAS system. It has been speculated that when ACE2 is occupied by the virus, its effects in limiting the amount and activity of Ang-II is decreased; Ang-II is consequently increased and it has been reported to induce a proinflammatory effect via the AT1R receptor (Marchesi et al., 2008; Eguchi et al., 2018). The Ang-II/AT1R system activates disintegrin and the metalloprotease ADAM 17 (also known as TNFα cleavage enzyme TACE), which lead to the intracellular production of epidermal growth factor ligands (EGFR) and TNFα production, with subsequent stimulation of the transcription factor NF-K B, a pivotal player in proinflammatory cytokines release. Additionally, ADAM 17 activation induces the production of the soluble form of IL-6Rα, active on IL-6-STAT3 pathway, which in turn amplifies NF-K B signaling (Murakami et al., 2019; Takimoto-Ohnishi and Murakami, 2019; Palau et al., 2020). The convergence on hyperactivation of NF-K B seems to be crucial in inducing the cytokine storm. The mechanism is self-feeding, given that NF-K B induces the expression of the angiotensinogen gene, amplifying the Ang-II inflammatory response (Costanzo et al., 2003; Hirano and Murakami, 2020).","tracks":[{"project":"LitCovid-sample-PD-NCBITaxon","denotations":[{"id":"T367","span":{"begin":73,"end":83},"obj":"Species"},{"id":"T368","span":{"begin":73,"end":77},"obj":"Species"}],"attributes":[{"id":"A367","pred":"ncbi_taxonomy_id","subj":"T367","obj":"NCBItxid:2697049"},{"id":"A368","pred":"ncbi_taxonomy_id","subj":"T368","obj":"NCBItxid:694009"},{"subj":"T367","pred":"source","obj":"LitCovid-sample-PD-NCBITaxon"},{"subj":"T368","pred":"source","obj":"LitCovid-sample-PD-NCBITaxon"}],"namespaces":[{"prefix":"NCBItxid","uri":"http://purl.bioontology.org/ontology/NCBITAXON/"}]},{"project":"LitCovid-sample-sentences","denotations":[{"id":"T383","span":{"begin":0,"end":125},"obj":"Sentence"},{"id":"T384","span":{"begin":126,"end":422},"obj":"Sentence"},{"id":"T385","span":{"begin":423,"end":767},"obj":"Sentence"},{"id":"T386","span":{"begin":768,"end":1007},"obj":"Sentence"},{"id":"T387","span":{"begin":1008,"end":1104},"obj":"Sentence"},{"id":"T388","span":{"begin":1105,"end":1301},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T383","pred":"source","obj":"LitCovid-sample-sentences"},{"subj":"T384","pred":"source","obj":"LitCovid-sample-sentences"},{"subj":"T385","pred":"source","obj":"LitCovid-sample-sentences"},{"subj":"T386","pred":"source","obj":"LitCovid-sample-sentences"},{"subj":"T387","pred":"source","obj":"LitCovid-sample-sentences"},{"subj":"T388","pred":"source","obj":"LitCovid-sample-sentences"}]},{"project":"LitCovid-sample-Pubtator","denotations":[{"id":"1771","span":{"begin":87,"end":90},"obj":"Gene"},{"id":"1772","span":{"begin":91,"end":95},"obj":"Gene"},{"id":"1773","span":{"begin":159,"end":163},"obj":"Gene"},{"id":"1774","span":{"begin":434,"end":438},"obj":"Gene"},{"id":"1775","span":{"begin":492,"end":499},"obj":"Gene"},{"id":"1776","span":{"begin":515,"end":519},"obj":"Gene"},{"id":"1777","span":{"begin":536,"end":540},"obj":"Gene"},{"id":"1778","span":{"begin":622,"end":626},"obj":"Gene"},{"id":"1779","span":{"begin":632,"end":636},"obj":"Gene"},{"id":"1780","span":{"begin":782,"end":789},"obj":"Gene"},{"id":"1781","span":{"begin":847,"end":853},"obj":"Gene"},{"id":"1782","span":{"begin":865,"end":869},"obj":"Gene"},{"id":"1783","span":{"begin":870,"end":875},"obj":"Gene"},{"id":"1784","span":{"begin":1184,"end":1199},"obj":"Gene"},{"id":"1785","span":{"begin":73,"end":83},"obj":"Species"}],"attributes":[{"id":"A1782","pred":"pubann:denotes","subj":"1782","obj":"Gene:3569"},{"id":"A1776","pred":"pubann:denotes","subj":"1776","obj":"Gene:7124"},{"id":"A1784","pred":"pubann:denotes","subj":"1784","obj":"Gene:183"},{"id":"A1773","pred":"pubann:denotes","subj":"1773","obj":"Gene:59272"},{"id":"A1771","pred":"pubann:denotes","subj":"1771","obj":"Gene:1636"},{"id":"A1774","pred":"pubann:denotes","subj":"1774","obj":"Gene:185"},{"id":"A1778","pred":"pubann:denotes","subj":"1778","obj":"Gene:1956"},{"id":"A1772","pred":"pubann:denotes","subj":"1772","obj":"Gene:59272"},{"id":"A1779","pred":"pubann:denotes","subj":"1779","obj":"Gene:7124"},{"id":"A1777","pred":"pubann:denotes","subj":"1777","obj":"Gene:6868"},{"id":"A1783","pred":"pubann:denotes","subj":"1783","obj":"Gene:6774"},{"id":"A1775","pred":"pubann:denotes","subj":"1775","obj":"Gene:6868"},{"id":"A1780","pred":"pubann:denotes","subj":"1780","obj":"Gene:6868"},{"id":"A1781","pred":"pubann:denotes","subj":"1781","obj":"Gene:3570"},{"id":"A1785","pred":"pubann:denotes","subj":"1785","obj":"Tax:2697049"},{"subj":"1771","pred":"source","obj":"LitCovid-sample-Pubtator"},{"subj":"1772","pred":"source","obj":"LitCovid-sample-Pubtator"},{"subj":"1773","pred":"source","obj":"LitCovid-sample-Pubtator"},{"subj":"1774","pred":"source","obj":"LitCovid-sample-Pubtator"},{"subj":"1775","pred":"source","obj":"LitCovid-sample-Pubtator"},{"subj":"1776","pred":"source","obj":"LitCovid-sample-Pubtator"},{"subj":"1777","pred":"source","obj":"LitCovid-sample-Pubtator"},{"subj":"1778","pred":"source","obj":"LitCovid-sample-Pubtator"},{"subj":"1779","pred":"source","obj":"LitCovid-sample-Pubtator"},{"subj":"1780","pred":"source","obj":"LitCovid-sample-Pubtator"},{"subj":"1781","pred":"source","obj":"LitCovid-sample-Pubtator"},{"subj":"1782","pred":"source","obj":"LitCovid-sample-Pubtator"},{"subj":"1783","pred":"source","obj":"LitCovid-sample-Pubtator"},{"subj":"1784","pred":"source","obj":"LitCovid-sample-Pubtator"},{"subj":"1785","pred":"source","obj":"LitCovid-sample-Pubtator"}]},{"project":"LitCovid-sample-UniProt","denotations":[{"id":"T5927","span":{"begin":87,"end":90},"obj":"Protein"},{"id":"T5952","span":{"begin":91,"end":95},"obj":"Protein"},{"id":"T5953","span":{"begin":159,"end":163},"obj":"Protein"},{"id":"T5954","span":{"begin":456,"end":467},"obj":"Protein"},{"id":"T5965","span":{"begin":492,"end":499},"obj":"Protein"},{"id":"T5974","span":{"begin":589,"end":612},"obj":"Protein"},{"id":"T5991","span":{"begin":782,"end":789},"obj":"Protein"},{"id":"T6000","span":{"begin":865,"end":869},"obj":"Protein"},{"id":"T6044","span":{"begin":1184,"end":1199},"obj":"Protein"}],"attributes":[{"id":"A5927","pred":"uniprot_id","subj":"T5927","obj":"https://www.uniprot.org/uniprot/Q9GLN7"},{"id":"A5928","pred":"uniprot_id","subj":"T5927","obj":"https://www.uniprot.org/uniprot/Q9GLN6"},{"id":"A5929","pred":"uniprot_id","subj":"T5927","obj":"https://www.uniprot.org/uniprot/Q9EQM9"},{"id":"A5930","pred":"uniprot_id","subj":"T5927","obj":"https://www.uniprot.org/uniprot/Q8CFN1"},{"id":"A5931","pred":"uniprot_id","subj":"T5927","obj":"https://www.uniprot.org/uniprot/Q7TMC6"},{"id":"A5932","pred":"uniprot_id","subj":"T5927","obj":"https://www.uniprot.org/uniprot/Q7M4L4"},{"id":"A5933","pred":"uniprot_id","subj":"T5927","obj":"https://www.uniprot.org/uniprot/Q6GTS2"},{"id":"A5934","pred":"uniprot_id","subj":"T5927","obj":"https://www.uniprot.org/uniprot/Q59GY8"},{"id":"A5935","pred":"uniprot_id","subj":"T5927","obj":"https://www.uniprot.org/uniprot/Q53YX9"},{"id":"A5936","pred":"uniprot_id","subj":"T5927","obj":"https://www.uniprot.org/uniprot/Q50JE5"},{"id":"A5937","pred":"uniprot_id","subj":"T5927","obj":"https://www.uniprot.org/uniprot/Q10751"},{"id":"A5938","pred":"uniprot_id","subj":"T5927","obj":"https://www.uniprot.org/uniprot/Q0GA41"},{"id":"A5939","pred":"uniprot_id","subj":"T5927","obj":"https://www.uniprot.org/uniprot/P47820"},{"id":"A5940","pred":"uniprot_id","subj":"T5927","obj":"https://www.uniprot.org/uniprot/P22968"},{"id":"A5941","pred":"uniprot_id","subj":"T5927","obj":"https://www.uniprot.org/uniprot/P22967"},{"id":"A5942","pred":"uniprot_id","subj":"T5927","obj":"https://www.uniprot.org/uniprot/P22966"},{"id":"A5943","pred":"uniprot_id","subj":"T5927","obj":"https://www.uniprot.org/uniprot/P12822"},{"id":"A5944","pred":"uniprot_id","subj":"T5927","obj":"https://www.uniprot.org/uniprot/P12821"},{"id":"A5945","pred":"uniprot_id","subj":"T5927","obj":"https://www.uniprot.org/uniprot/P12820"},{"id":"A5946","pred":"uniprot_id","subj":"T5927","obj":"https://www.uniprot.org/uniprot/P09470"},{"id":"A5947","pred":"uniprot_id","subj":"T5927","obj":"https://www.uniprot.org/uniprot/O02852"},{"id":"A5948","pred":"uniprot_id","subj":"T5927","obj":"https://www.uniprot.org/uniprot/E7EU16"},{"id":"A5949","pred":"uniprot_id","subj":"T5927","obj":"https://www.uniprot.org/uniprot/B4DXI3"},{"id":"A5950","pred":"uniprot_id","subj":"T5927","obj":"https://www.uniprot.org/uniprot/B0LPF0"},{"id":"A5951","pred":"uniprot_id","subj":"T5927","obj":"https://www.uniprot.org/uniprot/Q9VJV3"},{"id":"A5952","pred":"uniprot_id","subj":"T5952","obj":"https://www.uniprot.org/uniprot/Q9UFZ6"},{"id":"A5953","pred":"uniprot_id","subj":"T5953","obj":"https://www.uniprot.org/uniprot/Q9UFZ6"},{"id":"A5954","pred":"uniprot_id","subj":"T5954","obj":"https://www.uniprot.org/uniprot/Q9YI19"},{"id":"A5955","pred":"uniprot_id","subj":"T5954","obj":"https://www.uniprot.org/uniprot/Q9PVK9"},{"id":"A5956","pred":"uniprot_id","subj":"T5954","obj":"https://www.uniprot.org/uniprot/Q9IAX6"},{"id":"A5957","pred":"uniprot_id","subj":"T5954","obj":"https://www.uniprot.org/uniprot/Q7SZE0"},{"id":"A5958","pred":"uniprot_id","subj":"T5954","obj":"https://www.uniprot.org/uniprot/Q7SZD7"},{"id":"A5959","pred":"uniprot_id","subj":"T5954","obj":"https://www.uniprot.org/uniprot/Q7SZD6"},{"id":"A5960","pred":"uniprot_id","subj":"T5954","obj":"https://www.uniprot.org/uniprot/Q5EE07"},{"id":"A5961","pred":"uniprot_id","subj":"T5954","obj":"https://www.uniprot.org/uniprot/P0DMH4"},{"id":"A5962","pred":"uniprot_id","subj":"T5954","obj":"https://www.uniprot.org/uniprot/P0C6E3"},{"id":"A5963","pred":"uniprot_id","subj":"T5954","obj":"https://www.uniprot.org/uniprot/O73795"},{"id":"A5964","pred":"uniprot_id","subj":"T5954","obj":"https://www.uniprot.org/uniprot/E9NW26"},{"id":"A5965","pred":"uniprot_id","subj":"T5965","obj":"https://www.uniprot.org/uniprot/Q9Z1K9"},{"id":"A5966","pred":"uniprot_id","subj":"T5965","obj":"https://www.uniprot.org/uniprot/Q9Z0K3"},{"id":"A5967","pred":"uniprot_id","subj":"T5965","obj":"https://www.uniprot.org/uniprot/Q9Z0F8"},{"id":"A5968","pred":"uniprot_id","subj":"T5965","obj":"https://www.uniprot.org/uniprot/Q9R1U4"},{"id":"A5969","pred":"uniprot_id","subj":"T5965","obj":"https://www.uniprot.org/uniprot/Q505A7"},{"id":"A5970","pred":"uniprot_id","subj":"T5965","obj":"https://www.uniprot.org/uniprot/P78536"},{"id":"A5971","pred":"uniprot_id","subj":"T5965","obj":"https://www.uniprot.org/uniprot/O88726"},{"id":"A5972","pred":"uniprot_id","subj":"T5965","obj":"https://www.uniprot.org/uniprot/O77636"},{"id":"A5973","pred":"uniprot_id","subj":"T5965","obj":"https://www.uniprot.org/uniprot/O60226"},{"id":"A5974","pred":"uniprot_id","subj":"T5974","obj":"https://www.uniprot.org/uniprot/Q9GU69"},{"id":"A5975","pred":"uniprot_id","subj":"T5974","obj":"https://www.uniprot.org/uniprot/Q9BEA0"},{"id":"A5976","pred":"uniprot_id","subj":"T5974","obj":"https://www.uniprot.org/uniprot/Q9BDQ0"},{"id":"A5977","pred":"uniprot_id","subj":"T5974","obj":"https://www.uniprot.org/uniprot/Q95ND4"},{"id":"A5978","pred":"uniprot_id","subj":"T5974","obj":"https://www.uniprot.org/uniprot/Q6P9J2"},{"id":"A5979","pred":"uniprot_id","subj":"T5974","obj":"https://www.uniprot.org/uniprot/Q63183"},{"id":"A5980","pred":"uniprot_id","subj":"T5974","obj":"https://www.uniprot.org/uniprot/Q569W5"},{"id":"A5981","pred":"uniprot_id","subj":"T5974","obj":"https://www.uniprot.org/uniprot/Q52LZ6"},{"id":"A5982","pred":"uniprot_id","subj":"T5974","obj":"https://www.uniprot.org/uniprot/Q00968"},{"id":"A5983","pred":"uniprot_id","subj":"T5974","obj":"https://www.uniprot.org/uniprot/P07522"},{"id":"A5984","pred":"uniprot_id","subj":"T5974","obj":"https://www.uniprot.org/uniprot/P01133"},{"id":"A5985","pred":"uniprot_id","subj":"T5974","obj":"https://www.uniprot.org/uniprot/P01132"},{"id":"A5986","pred":"uniprot_id","subj":"T5974","obj":"https://www.uniprot.org/uniprot/O62759"},{"id":"A5987","pred":"uniprot_id","subj":"T5974","obj":"https://www.uniprot.org/uniprot/E9QNX6"},{"id":"A5988","pred":"uniprot_id","subj":"T5974","obj":"https://www.uniprot.org/uniprot/E9PBF0"},{"id":"A5989","pred":"uniprot_id","subj":"T5974","obj":"https://www.uniprot.org/uniprot/E7EVD2"},{"id":"A5990","pred":"uniprot_id","subj":"T5974","obj":"https://www.uniprot.org/uniprot/B4DRK7"},{"id":"A5991","pred":"uniprot_id","subj":"T5991","obj":"https://www.uniprot.org/uniprot/Q9Z1K9"},{"id":"A5992","pred":"uniprot_id","subj":"T5991","obj":"https://www.uniprot.org/uniprot/Q9Z0K3"},{"id":"A5993","pred":"uniprot_id","subj":"T5991","obj":"https://www.uniprot.org/uniprot/Q9Z0F8"},{"id":"A5994","pred":"uniprot_id","subj":"T5991","obj":"https://www.uniprot.org/uniprot/Q9R1U4"},{"id":"A5995","pred":"uniprot_id","subj":"T5991","obj":"https://www.uniprot.org/uniprot/Q505A7"},{"id":"A5996","pred":"uniprot_id","subj":"T5991","obj":"https://www.uniprot.org/uniprot/P78536"},{"id":"A5997","pred":"uniprot_id","subj":"T5991","obj":"https://www.uniprot.org/uniprot/O88726"},{"id":"A5998","pred":"uniprot_id","subj":"T5991","obj":"https://www.uniprot.org/uniprot/O77636"},{"id":"A5999","pred":"uniprot_id","subj":"T5991","obj":"https://www.uniprot.org/uniprot/O60226"},{"id":"A6000","pred":"uniprot_id","subj":"T6000","obj":"https://www.uniprot.org/uniprot/Q9XT80"},{"id":"A6001","pred":"uniprot_id","subj":"T6000","obj":"https://www.uniprot.org/uniprot/Q9UCU4"},{"id":"A6002","pred":"uniprot_id","subj":"T6000","obj":"https://www.uniprot.org/uniprot/Q9UCU3"},{"id":"A6003","pred":"uniprot_id","subj":"T6000","obj":"https://www.uniprot.org/uniprot/Q9UCU2"},{"id":"A6004","pred":"uniprot_id","subj":"T6000","obj":"https://www.uniprot.org/uniprot/Q9MZR1"},{"id":"A6005","pred":"uniprot_id","subj":"T6000","obj":"https://www.uniprot.org/uniprot/Q9MYZ7"},{"id":"A6006","pred":"uniprot_id","subj":"T6000","obj":"https://www.uniprot.org/uniprot/Q95KN6"},{"id":"A6007","pred":"uniprot_id","subj":"T6000","obj":"https://www.uniprot.org/uniprot/Q95181"},{"id":"A6008","pred":"uniprot_id","subj":"T6000","obj":"https://www.uniprot.org/uniprot/Q90YI0"},{"id":"A6009","pred":"uniprot_id","subj":"T6000","obj":"https://www.uniprot.org/uniprot/Q8MKH0"},{"id":"A6010","pred":"uniprot_id","subj":"T6000","obj":"https://www.uniprot.org/uniprot/Q8BN26"},{"id":"A6011","pred":"uniprot_id","subj":"T6000","obj":"https://www.uniprot.org/uniprot/Q865X6"},{"id":"A6012","pred":"uniprot_id","subj":"T6000","obj":"https://www.uniprot.org/uniprot/Q865W7"},{"id":"A6013","pred":"uniprot_id","subj":"T6000","obj":"https://www.uniprot.org/uniprot/Q6V919"},{"id":"A6014","pred":"uniprot_id","subj":"T6000","obj":"https://www.uniprot.org/uniprot/Q6L6X6"},{"id":"A6015","pred":"uniprot_id","subj":"T6000","obj":"https://www.uniprot.org/uniprot/Q5I6E3"},{"id":"A6016","pred":"uniprot_id","subj":"T6000","obj":"https://www.uniprot.org/uniprot/Q3UCQ0"},{"id":"A6017","pred":"uniprot_id","subj":"T6000","obj":"https://www.uniprot.org/uniprot/Q2MH06"},{"id":"A6018","pred":"uniprot_id","subj":"T6000","obj":"https://www.uniprot.org/uniprot/Q28819"},{"id":"A6019","pred":"uniprot_id","subj":"T6000","obj":"https://www.uniprot.org/uniprot/Q28747"},{"id":"A6020","pred":"uniprot_id","subj":"T6000","obj":"https://www.uniprot.org/uniprot/Q28319"},{"id":"A6021","pred":"uniprot_id","subj":"T6000","obj":"https://www.uniprot.org/uniprot/Q25BC2"},{"id":"A6022","pred":"uniprot_id","subj":"T6000","obj":"https://www.uniprot.org/uniprot/Q0PW36"},{"id":"A6023","pred":"uniprot_id","subj":"T6000","obj":"https://www.uniprot.org/uniprot/Q0GGL7"},{"id":"A6024","pred":"uniprot_id","subj":"T6000","obj":"https://www.uniprot.org/uniprot/Q08DT2"},{"id":"A6025","pred":"uniprot_id","subj":"T6000","obj":"https://www.uniprot.org/uniprot/P79341"},{"id":"A6026","pred":"uniprot_id","subj":"T6000","obj":"https://www.uniprot.org/uniprot/P51494"},{"id":"A6027","pred":"uniprot_id","subj":"T6000","obj":"https://www.uniprot.org/uniprot/P46650"},{"id":"A6028","pred":"uniprot_id","subj":"T6000","obj":"https://www.uniprot.org/uniprot/P41693"},{"id":"A6029","pred":"uniprot_id","subj":"T6000","obj":"https://www.uniprot.org/uniprot/P41683"},{"id":"A6030","pred":"uniprot_id","subj":"T6000","obj":"https://www.uniprot.org/uniprot/P41323"},{"id":"A6031","pred":"uniprot_id","subj":"T6000","obj":"https://www.uniprot.org/uniprot/P29455"},{"id":"A6032","pred":"uniprot_id","subj":"T6000","obj":"https://www.uniprot.org/uniprot/P26893"},{"id":"A6033","pred":"uniprot_id","subj":"T6000","obj":"https://www.uniprot.org/uniprot/P26892"},{"id":"A6034","pred":"uniprot_id","subj":"T6000","obj":"https://www.uniprot.org/uniprot/P20607"},{"id":"A6035","pred":"uniprot_id","subj":"T6000","obj":"https://www.uniprot.org/uniprot/P08505"},{"id":"A6036","pred":"uniprot_id","subj":"T6000","obj":"https://www.uniprot.org/uniprot/P05231"},{"id":"A6037","pred":"uniprot_id","subj":"T6000","obj":"https://www.uniprot.org/uniprot/O46568"},{"id":"A6038","pred":"uniprot_id","subj":"T6000","obj":"https://www.uniprot.org/uniprot/O35736"},{"id":"A6039","pred":"uniprot_id","subj":"T6000","obj":"https://www.uniprot.org/uniprot/O19007"},{"id":"A6040","pred":"uniprot_id","subj":"T6000","obj":"https://www.uniprot.org/uniprot/B6CKP4"},{"id":"A6041","pred":"uniprot_id","subj":"T6000","obj":"https://www.uniprot.org/uniprot/A9QWQ9"},{"id":"A6042","pred":"uniprot_id","subj":"T6000","obj":"https://www.uniprot.org/uniprot/A3FBE9"},{"id":"A6043","pred":"uniprot_id","subj":"T6000","obj":"https://www.uniprot.org/uniprot/A0S0B0"},{"id":"A6044","pred":"uniprot_id","subj":"T6044","obj":"https://www.uniprot.org/uniprot/Q9TSZ0"},{"id":"A6045","pred":"uniprot_id","subj":"T6044","obj":"https://www.uniprot.org/uniprot/Q9GLP7"},{"id":"A6046","pred":"uniprot_id","subj":"T6044","obj":"https://www.uniprot.org/uniprot/Q9GLP6"},{"id":"A6047","pred":"uniprot_id","subj":"T6044","obj":"https://www.uniprot.org/uniprot/Q9GLN8"},{"id":"A6048","pred":"uniprot_id","subj":"T6044","obj":"https://www.uniprot.org/uniprot/Q96F91"},{"id":"A6049","pred":"uniprot_id","subj":"T6044","obj":"https://www.uniprot.org/uniprot/Q16359"},{"id":"A6050","pred":"uniprot_id","subj":"T6044","obj":"https://www.uniprot.org/uniprot/Q16358"},{"id":"A6051","pred":"uniprot_id","subj":"T6044","obj":"https://www.uniprot.org/uniprot/P67886"},{"id":"A6052","pred":"uniprot_id","subj":"T6044","obj":"https://www.uniprot.org/uniprot/P67885"},{"id":"A6053","pred":"uniprot_id","subj":"T6044","obj":"https://www.uniprot.org/uniprot/P20757"},{"id":"A6054","pred":"uniprot_id","subj":"T6044","obj":"https://www.uniprot.org/uniprot/P11859"},{"id":"A6055","pred":"uniprot_id","subj":"T6044","obj":"https://www.uniprot.org/uniprot/P01019"},{"id":"A6056","pred":"uniprot_id","subj":"T6044","obj":"https://www.uniprot.org/uniprot/P01018"},{"id":"A6057","pred":"uniprot_id","subj":"T6044","obj":"https://www.uniprot.org/uniprot/P01017"},{"id":"A6058","pred":"uniprot_id","subj":"T6044","obj":"https://www.uniprot.org/uniprot/P01016"},{"id":"A6059","pred":"uniprot_id","subj":"T6044","obj":"https://www.uniprot.org/uniprot/P01015"},{"id":"A6060","pred":"uniprot_id","subj":"T6044","obj":"https://www.uniprot.org/uniprot/A0A3Q1LGY9"},{"subj":"T5927","pred":"source","obj":"LitCovid-sample-UniProt"},{"subj":"T5952","pred":"source","obj":"LitCovid-sample-UniProt"},{"subj":"T5953","pred":"source","obj":"LitCovid-sample-UniProt"},{"subj":"T5954","pred":"source","obj":"LitCovid-sample-UniProt"},{"subj":"T5965","pred":"source","obj":"LitCovid-sample-UniProt"},{"subj":"T5974","pred":"source","obj":"LitCovid-sample-UniProt"},{"subj":"T5991","pred":"source","obj":"LitCovid-sample-UniProt"},{"subj":"T6000","pred":"source","obj":"LitCovid-sample-UniProt"},{"subj":"T6044","pred":"source","obj":"LitCovid-sample-UniProt"}]},{"project":"LitCovid-sample-PD-IDO","denotations":[{"id":"T258","span":{"begin":183,"end":188},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T259","span":{"begin":575,"end":585},"obj":"http://purl.obolibrary.org/obo/IDO_0000607"},{"id":"T260","span":{"begin":599,"end":605},"obj":"http://purl.obolibrary.org/obo/GO_0040007"},{"id":"T261","span":{"begin":637,"end":647},"obj":"http://purl.obolibrary.org/obo/IDO_0000607"},{"id":"T262","span":{"begin":813,"end":823},"obj":"http://purl.obolibrary.org/obo/IDO_0000607"}],"attributes":[{"subj":"T258","pred":"source","obj":"LitCovid-sample-PD-IDO"},{"subj":"T259","pred":"source","obj":"LitCovid-sample-PD-IDO"},{"subj":"T260","pred":"source","obj":"LitCovid-sample-PD-IDO"},{"subj":"T261","pred":"source","obj":"LitCovid-sample-PD-IDO"},{"subj":"T262","pred":"source","obj":"LitCovid-sample-PD-IDO"}]},{"project":"LitCovid-sample-PD-FMA","denotations":[{"id":"T436","span":{"begin":749,"end":758},"obj":"Body_part"},{"id":"T437","span":{"begin":1089,"end":1097},"obj":"Body_part"},{"id":"T438","span":{"begin":1200,"end":1204},"obj":"Body_part"}],"attributes":[{"id":"A436","pred":"fma_id","subj":"T436","obj":"http://purl.org/sig/ont/fma/fma84050"},{"id":"A437","pred":"fma_id","subj":"T437","obj":"http://purl.org/sig/ont/fma/fma84050"},{"id":"A438","pred":"fma_id","subj":"T438","obj":"http://purl.org/sig/ont/fma/fma74402"},{"subj":"T436","pred":"source","obj":"LitCovid-sample-PD-FMA"},{"subj":"T437","pred":"source","obj":"LitCovid-sample-PD-FMA"},{"subj":"T438","pred":"source","obj":"LitCovid-sample-PD-FMA"}]},{"project":"LitCovid-sample-PD-MONDO","denotations":[{"id":"T381","span":{"begin":73,"end":83},"obj":"Disease"},{"id":"T382","span":{"begin":73,"end":77},"obj":"Disease"}],"attributes":[{"id":"A381","pred":"mondo_id","subj":"T381","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A382","pred":"mondo_id","subj":"T382","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"subj":"T381","pred":"source","obj":"LitCovid-sample-PD-MONDO"},{"subj":"T382","pred":"source","obj":"LitCovid-sample-PD-MONDO"}]},{"project":"LitCovid-sample-PD-GO-BP-0","denotations":[{"id":"T132","span":{"begin":599,"end":605},"obj":"http://purl.obolibrary.org/obo/GO_0040007"},{"id":"T133","span":{"begin":622,"end":626},"obj":"http://purl.obolibrary.org/obo/GO_0005006"},{"id":"T134","span":{"begin":684,"end":697},"obj":"http://purl.obolibrary.org/obo/GO_0006351"},{"id":"T135","span":{"begin":847,"end":852},"obj":"http://purl.obolibrary.org/obo/GO_0004915"},{"id":"T136","span":{"begin":916,"end":925},"obj":"http://purl.obolibrary.org/obo/GO_0023052"},{"id":"T137","span":{"begin":1228,"end":1249},"obj":"http://purl.obolibrary.org/obo/GO_0006954"}],"attributes":[{"subj":"T132","pred":"source","obj":"LitCovid-sample-PD-GO-BP-0"},{"subj":"T133","pred":"source","obj":"LitCovid-sample-PD-GO-BP-0"},{"subj":"T134","pred":"source","obj":"LitCovid-sample-PD-GO-BP-0"},{"subj":"T135","pred":"source","obj":"LitCovid-sample-PD-GO-BP-0"},{"subj":"T136","pred":"source","obj":"LitCovid-sample-PD-GO-BP-0"},{"subj":"T137","pred":"source","obj":"LitCovid-sample-PD-GO-BP-0"}]},{"project":"LitCovid-sample-PD-HP","denotations":[{"id":"T69","span":{"begin":1089,"end":1103},"obj":"Phenotype"}],"attributes":[{"id":"A69","pred":"hp_id","subj":"T69","obj":"http://purl.obolibrary.org/obo/HP_0033041"},{"subj":"T69","pred":"source","obj":"LitCovid-sample-PD-HP"}]},{"project":"LitCovid-sample-GO-BP","denotations":[{"id":"T136","span":{"begin":599,"end":605},"obj":"http://purl.obolibrary.org/obo/GO_0040007"},{"id":"T137","span":{"begin":622,"end":626},"obj":"http://purl.obolibrary.org/obo/GO_0005006"},{"id":"T138","span":{"begin":684,"end":704},"obj":"http://purl.obolibrary.org/obo/GO_0000981"},{"id":"T139","span":{"begin":684,"end":697},"obj":"http://purl.obolibrary.org/obo/GO_0006351"},{"id":"T140","span":{"begin":847,"end":852},"obj":"http://purl.obolibrary.org/obo/GO_0004915"},{"id":"T141","span":{"begin":916,"end":925},"obj":"http://purl.obolibrary.org/obo/GO_0023052"},{"id":"T142","span":{"begin":1228,"end":1249},"obj":"http://purl.obolibrary.org/obo/GO_0006954"}],"attributes":[{"subj":"T136","pred":"source","obj":"LitCovid-sample-GO-BP"},{"subj":"T137","pred":"source","obj":"LitCovid-sample-GO-BP"},{"subj":"T138","pred":"source","obj":"LitCovid-sample-GO-BP"},{"subj":"T139","pred":"source","obj":"LitCovid-sample-GO-BP"},{"subj":"T140","pred":"source","obj":"LitCovid-sample-GO-BP"},{"subj":"T141","pred":"source","obj":"LitCovid-sample-GO-BP"},{"subj":"T142","pred":"source","obj":"LitCovid-sample-GO-BP"}]},{"project":"LitCovid-PD-HP","denotations":[{"id":"T72","span":{"begin":1089,"end":1103},"obj":"Phenotype"}],"attributes":[{"id":"A72","pred":"hp_id","subj":"T72","obj":"http://purl.obolibrary.org/obo/HP_0033041"},{"subj":"T72","pred":"source","obj":"LitCovid-PD-HP"}]},{"project":"LitCovid-PubTator","denotations":[{"id":"1771","span":{"begin":87,"end":90},"obj":"Gene"},{"id":"1772","span":{"begin":91,"end":95},"obj":"Gene"},{"id":"1773","span":{"begin":159,"end":163},"obj":"Gene"},{"id":"1774","span":{"begin":434,"end":438},"obj":"Gene"},{"id":"1775","span":{"begin":492,"end":499},"obj":"Gene"},{"id":"1776","span":{"begin":515,"end":519},"obj":"Gene"},{"id":"1777","span":{"begin":536,"end":540},"obj":"Gene"},{"id":"1778","span":{"begin":622,"end":626},"obj":"Gene"},{"id":"1779","span":{"begin":632,"end":636},"obj":"Gene"},{"id":"1780","span":{"begin":782,"end":789},"obj":"Gene"},{"id":"1781","span":{"begin":847,"end":853},"obj":"Gene"},{"id":"1782","span":{"begin":865,"end":869},"obj":"Gene"},{"id":"1783","span":{"begin":870,"end":875},"obj":"Gene"},{"id":"1784","span":{"begin":1184,"end":1199},"obj":"Gene"},{"id":"1785","span":{"begin":73,"end":83},"obj":"Species"}],"attributes":[{"id":"A1771","pred":"tao:has_database_id","subj":"1771","obj":"Gene:1636"},{"id":"A1772","pred":"tao:has_database_id","subj":"1772","obj":"Gene:59272"},{"id":"A1773","pred":"tao:has_database_id","subj":"1773","obj":"Gene:59272"},{"id":"A1774","pred":"tao:has_database_id","subj":"1774","obj":"Gene:185"},{"id":"A1775","pred":"tao:has_database_id","subj":"1775","obj":"Gene:6868"},{"id":"A1776","pred":"tao:has_database_id","subj":"1776","obj":"Gene:7124"},{"id":"A1777","pred":"tao:has_database_id","subj":"1777","obj":"Gene:6868"},{"id":"A1778","pred":"tao:has_database_id","subj":"1778","obj":"Gene:1956"},{"id":"A1779","pred":"tao:has_database_id","subj":"1779","obj":"Gene:7124"},{"id":"A1780","pred":"tao:has_database_id","subj":"1780","obj":"Gene:6868"},{"id":"A1781","pred":"tao:has_database_id","subj":"1781","obj":"Gene:3570"},{"id":"A1782","pred":"tao:has_database_id","subj":"1782","obj":"Gene:3569"},{"id":"A1783","pred":"tao:has_database_id","subj":"1783","obj":"Gene:6774"},{"id":"A1784","pred":"tao:has_database_id","subj":"1784","obj":"Gene:183"},{"id":"A1785","pred":"tao:has_database_id","subj":"1785","obj":"Tax:2697049"},{"subj":"1771","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1772","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1773","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1774","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1775","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1776","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1777","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1778","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1779","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1780","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1781","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1782","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1783","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1784","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1785","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T383","span":{"begin":0,"end":125},"obj":"Sentence"},{"id":"T384","span":{"begin":126,"end":422},"obj":"Sentence"},{"id":"T385","span":{"begin":423,"end":767},"obj":"Sentence"},{"id":"T386","span":{"begin":768,"end":1007},"obj":"Sentence"},{"id":"T387","span":{"begin":1008,"end":1104},"obj":"Sentence"},{"id":"T388","span":{"begin":1105,"end":1301},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T383","pred":"source","obj":"LitCovid-sentences"},{"subj":"T384","pred":"source","obj":"LitCovid-sentences"},{"subj":"T385","pred":"source","obj":"LitCovid-sentences"},{"subj":"T386","pred":"source","obj":"LitCovid-sentences"},{"subj":"T387","pred":"source","obj":"LitCovid-sentences"},{"subj":"T388","pred":"source","obj":"LitCovid-sentences"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-sample-PD-NCBITaxon","color":"#b893ec","default":true},{"id":"LitCovid-sample-sentences","color":"#93ec9e"},{"id":"LitCovid-sample-Pubtator","color":"#ec93a1"},{"id":"LitCovid-sample-UniProt","color":"#93bbec"},{"id":"LitCovid-sample-PD-IDO","color":"#d5ec93"},{"id":"LitCovid-sample-PD-FMA","color":"#e893ec"},{"id":"LitCovid-sample-PD-MONDO","color":"#93ecce"},{"id":"LitCovid-sample-PD-GO-BP-0","color":"#ecb493"},{"id":"LitCovid-sample-PD-HP","color":"#9a93ec"},{"id":"LitCovid-sample-GO-BP","color":"#a5ec93"},{"id":"LitCovid-PD-HP","color":"#ec93bf"},{"id":"LitCovid-PubTator","color":"#93d9ec"},{"id":"LitCovid-sentences","color":"#ece593"}]}]}}