PMC:7243768 / 61150-63897
Annnotations
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 2381 | 2384-2389 | Gene | denotes | IFN-β | Gene:3439 |
| 2382 | 1426-1434 | Species | denotes | SARS-CoV | Tax:694009 |
| 2383 | 1511-1519 | Species | denotes | SARS-CoV | Tax:694009 |
| 2384 | 1725-1733 | Species | denotes | SARS-CoV | Tax:694009 |
| 2385 | 1994-2002 | Species | denotes | SARS-CoV | Tax:694009 |
| 2386 | 2004-2012 | Species | denotes | MERS-CoV | Tax:1335626 |
| 2387 | 2014-2024 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 2388 | 2096-2104 | Species | denotes | MERS-CoV | Tax:1335626 |
| 2389 | 2106-2116 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 2390 | 2281-2289 | Species | denotes | MERS-CoV | Tax:1335626 |
| 2391 | 2390-2398 | Species | denotes | MERS-CoV | Tax:1335626 |
| 2392 | 2557-2567 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 2393 | 1236-1244 | Species | denotes | SARS-CoV | Tax:694009 |
| 2394 | 1605-1613 | Species | denotes | SARS-CoV | Tax:694009 |
| 2395 | 1226-1235 | Chemical | denotes | Ribavirin | MESH:D012254 |
| 2396 | 1256-1266 | Chemical | denotes | nucleoside | MESH:D009705 |
| 2397 | 1416-1425 | Chemical | denotes | Lopinavir | MESH:D061466 |
| 2398 | 1501-1510 | Chemical | denotes | Ritonavir | MESH:D019438 |
| 2399 | 1586-1604 | Chemical | denotes | Methylprednisolone | MESH:D008775 |
| 2400 | 1820-1838 | Chemical | denotes | Methylprednisolone | MESH:D008775 |
| 2401 | 1865-1879 | Chemical | denotes | hydrocortisone | MESH:D006854 |
| 2402 | 1912-1930 | Chemical | denotes | methylprednisolone | MESH:D008775 |
| 2403 | 2076-2095 | Chemical | denotes | Lopinavir/ritonavir | MESH:C558899 |
| 2404 | 2360-2379 | Chemical | denotes | Lopinavir/ritonavir | MESH:C558899 |
| 2405 | 2538-2556 | Chemical | denotes | Hydroxychloroquine | MESH:D006886 |
| 2406 | 1315-1321 | Disease | denotes | Anemia | MESH:D000740 |
| 2407 | 1323-1335 | Disease | denotes | hypocalcemia | MESH:D006996 |
| 2408 | 1337-1351 | Disease | denotes | hypomagnesemia | MESH:C537153 |
| 2409 | 1394-1405 | Disease | denotes | bradycardia | MESH:D001919 |
| 2410 | 1455-1463 | Disease | denotes | Diarrhea | MESH:D003967 |
| 2411 | 1465-1471 | Disease | denotes | nausea | MESH:D009325 |
| 2412 | 1473-1481 | Disease | denotes | vomiting | MESH:D014839 |
| 2413 | 1483-1491 | Disease | denotes | headache | MESH:D006261 |
| 2414 | 1540-1548 | Disease | denotes | Diarrhea | MESH:D003967 |
| 2415 | 1550-1556 | Disease | denotes | nausea | MESH:D009325 |
| 2416 | 1558-1566 | Disease | denotes | vomiting | MESH:D014839 |
| 2417 | 1568-1576 | Disease | denotes | headache | MESH:D006261 |
| 2418 | 1652-1660 | Disease | denotes | diabetes | MESH:D003920 |
| 2419 | 1662-1680 | Disease | denotes | avascular necrosis | MESH:D010020 |
| 2420 | 1682-1694 | Disease | denotes | osteoporosis | MESH:D010024 |
| 2421 | 1768-1781 | Disease | denotes | Aspergillosis | MESH:D001228 |
| 2422 | 2168-2177 | Disease | denotes | pneumonia | MESH:D011014 |
| 2423 | 2188-2207 | Disease | denotes | SARS-CoV-2 Diarrhea | MESH:C000657245 |
| 2424 | 2209-2215 | Disease | denotes | nausea | MESH:D009325 |
| 2425 | 2217-2225 | Disease | denotes | vomiting | MESH:D014839 |
| 2426 | 2227-2235 | Disease | denotes | headache | MESH:D006261 |
| 2427 | 2313-2321 | Disease | denotes | Diarrhea | MESH:D003967 |
| 2428 | 2323-2329 | Disease | denotes | nausea | MESH:D009325 |
| 2429 | 2331-2339 | Disease | denotes | vomiting | MESH:D014839 |
| 2430 | 2341-2349 | Disease | denotes | headache | MESH:D006261 |
| 2431 | 2442-2450 | Disease | denotes | necrosis | MESH:D009336 |
| 2432 | 2487-2495 | Disease | denotes | Diarrhea | MESH:D003967 |
| 2433 | 2497-2503 | Disease | denotes | nausea | MESH:D009325 |
| 2434 | 2505-2513 | Disease | denotes | vomiting | MESH:D014839 |
| 2435 | 2515-2523 | Disease | denotes | headache | MESH:D006261 |
| 2436 | 2569-2576 | Disease | denotes | Malaria | MESH:D008288 |
| 2437 | 2680-2702 | Disease | denotes | infected cell Diarrhea | MESH:D003967 |
| 2438 | 2704-2710 | Disease | denotes | nausea | MESH:D009325 |
| 2439 | 2712-2720 | Disease | denotes | vomiting | MESH:D014839 |
| 2440 | 2722-2730 | Disease | denotes | headache | MESH:D006261 |
| 2441 | 2732-2741 | Disease | denotes | dizziness | MESH:D004244 |
| 2445 | 1052-1060 | Species | denotes | SARS-CoV | Tax:694009 |
| 2446 | 1062-1070 | Species | denotes | MERS-CoV | Tax:1335626 |
| 2447 | 1076-1086 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 2465 | 55-65 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 2466 | 124-134 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 2467 | 236-244 | Species | denotes | patients | Tax:9606 |
| 2468 | 381-389 | Species | denotes | patients | Tax:9606 |
| 2469 | 891-901 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 2470 | 71-89 | Chemical | denotes | hydroxychloroquine | MESH:D006886 |
| 2471 | 154-172 | Chemical | denotes | hydroxychloroquine | MESH:D006886 |
| 2472 | 174-186 | Chemical | denotes | azithromycin | MESH:D017963 |
| 2473 | 275-293 | Chemical | denotes | hydroxychloroquine | MESH:D006886 |
| 2474 | 298-310 | Chemical | denotes | azithromycin | MESH:D017963 |
| 2475 | 403-421 | Chemical | denotes | hydroxychloroquine | MESH:D006886 |
| 2476 | 632-641 | Chemical | denotes | lopinavir | MESH:D061466 |
| 2477 | 762-773 | Chemical | denotes | chloroquine | MESH:D002738 |
| 2478 | 778-796 | Chemical | denotes | hydroxychloroquine | MESH:D006886 |
| 2479 | 527-535 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 2480 | 686-694 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 2481 | 986-1002 | Disease | denotes | heart arrhythmia | MESH:D001145 |
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T518 | 986-991 | Body_part | denotes | heart | http://purl.org/sig/ont/fma/fma7088 |
| T519 | 1947-1951 | Body_part | denotes | Lung | http://purl.org/sig/ont/fma/fma7195 |
| T520 | 1987-1993 | Body_part | denotes | plasma | http://purl.org/sig/ont/fma/fma62970 |
| T521 | 2299-2302 | Body_part | denotes | DNA | http://purl.org/sig/ont/fma/fma74412 |
| T522 | 2454-2459 | Body_part | denotes | lungs | http://purl.org/sig/ont/fma/fma68877 |
| T523 | 2479-2486 | Body_part | denotes | tissues | http://purl.org/sig/ont/fma/fma9637 |
| T524 | 2598-2606 | Body_part | denotes | endosome | http://purl.org/sig/ont/fma/fma67180 |
| T525 | 2689-2693 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T259 | 986-991 | Body_part | denotes | heart | http://purl.obolibrary.org/obo/UBERON_0000948 |
| T260 | 1947-1951 | Body_part | denotes | Lung | http://purl.obolibrary.org/obo/UBERON_0002048 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T705 | 55-63 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T706 | 55-59 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T707 | 124-132 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T708 | 124-128 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T709 | 527-535 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T710 | 686-694 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T711 | 891-899 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T712 | 891-895 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T713 | 992-1002 | Disease | denotes | arrhythmia | http://purl.obolibrary.org/obo/MONDO_0007263 |
| T714 | 1052-1060 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T715 | 1052-1056 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T716 | 1076-1084 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T717 | 1076-1080 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T718 | 1236-1244 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T719 | 1236-1240 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T720 | 1315-1321 | Disease | denotes | Anemia | http://purl.obolibrary.org/obo/MONDO_0002280 |
| T721 | 1323-1335 | Disease | denotes | hypocalcemia | http://purl.obolibrary.org/obo/MONDO_0018543 |
| T722 | 1337-1351 | Disease | denotes | hypomagnesemia | http://purl.obolibrary.org/obo/MONDO_0018100 |
| T723 | 1426-1434 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T724 | 1426-1430 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T725 | 1455-1463 | Disease | denotes | Diarrhea | http://purl.obolibrary.org/obo/MONDO_0001673 |
| T726 | 1511-1519 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T727 | 1511-1515 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T728 | 1540-1548 | Disease | denotes | Diarrhea | http://purl.obolibrary.org/obo/MONDO_0001673 |
| T729 | 1605-1613 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T730 | 1605-1609 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T731 | 1652-1660 | Disease | denotes | diabetes | http://purl.obolibrary.org/obo/MONDO_0005015 |
| T732 | 1662-1680 | Disease | denotes | avascular necrosis | http://purl.obolibrary.org/obo/MONDO_0005380|http://purl.obolibrary.org/obo/MONDO_0018373 |
| T734 | 1682-1694 | Disease | denotes | osteoporosis | http://purl.obolibrary.org/obo/MONDO_0005298 |
| T735 | 1725-1733 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T736 | 1725-1729 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T737 | 1768-1781 | Disease | denotes | Aspergillosis | http://purl.obolibrary.org/obo/MONDO_0005657 |
| T738 | 1947-1960 | Disease | denotes | Lung diseases | http://purl.obolibrary.org/obo/MONDO_0005275 |
| T739 | 1994-2002 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T740 | 1994-1998 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T741 | 2014-2022 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T742 | 2014-2018 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T743 | 2106-2114 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T744 | 2106-2110 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T745 | 2168-2177 | Disease | denotes | pneumonia | http://purl.obolibrary.org/obo/MONDO_0005249 |
| T746 | 2188-2196 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T747 | 2188-2192 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T748 | 2199-2207 | Disease | denotes | Diarrhea | http://purl.obolibrary.org/obo/MONDO_0001673 |
| T749 | 2268-2279 | Disease | denotes | Hepatitis-C | http://purl.obolibrary.org/obo/MONDO_0005231 |
| T750 | 2268-2277 | Disease | denotes | Hepatitis | http://purl.obolibrary.org/obo/MONDO_0002251 |
| T751 | 2313-2321 | Disease | denotes | Diarrhea | http://purl.obolibrary.org/obo/MONDO_0001673 |
| T752 | 2487-2495 | Disease | denotes | Diarrhea | http://purl.obolibrary.org/obo/MONDO_0001673 |
| T753 | 2557-2565 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T754 | 2557-2561 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T755 | 2569-2576 | Disease | denotes | Malaria | http://purl.obolibrary.org/obo/MONDO_0005136 |
| T756 | 2694-2702 | Disease | denotes | Diarrhea | http://purl.obolibrary.org/obo/MONDO_0001673 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T782 | 212-213 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T783 | 258-259 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T784 | 335-341 | http://purl.obolibrary.org/obo/UBERON_0000473 | denotes | tested |
| T785 | 552-558 | http://purl.obolibrary.org/obo/UBERON_0000473 | denotes | tested |
| T786 | 564-565 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T787 | 986-991 | http://purl.obolibrary.org/obo/UBERON_0000948 | denotes | heart |
| T788 | 986-991 | http://purl.obolibrary.org/obo/UBERON_0007100 | denotes | heart |
| T789 | 986-991 | http://purl.obolibrary.org/obo/UBERON_0015228 | denotes | heart |
| T790 | 986-991 | http://www.ebi.ac.uk/efo/EFO_0000815 | denotes | heart |
| T791 | 1947-1951 | http://purl.obolibrary.org/obo/UBERON_0002048 | denotes | Lung |
| T792 | 1947-1951 | http://www.ebi.ac.uk/efo/EFO_0000934 | denotes | Lung |
| T793 | 1987-1993 | http://purl.obolibrary.org/obo/UBERON_0001969 | denotes | plasma |
| T794 | 2454-2459 | http://www.ebi.ac.uk/efo/EFO_0000934 | denotes | lungs |
| T795 | 2534-2536 | http://purl.obolibrary.org/obo/CLO_0053733 | denotes | 11 |
| T796 | 2689-2693 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T79786 | 71-89 | Chemical | denotes | hydroxychloroquine | http://purl.obolibrary.org/obo/CHEBI_5801 |
| T58 | 154-172 | Chemical | denotes | hydroxychloroquine | http://purl.obolibrary.org/obo/CHEBI_5801 |
| T59 | 174-186 | Chemical | denotes | azithromycin | http://purl.obolibrary.org/obo/CHEBI_2955 |
| T41603 | 275-293 | Chemical | denotes | hydroxychloroquine | http://purl.obolibrary.org/obo/CHEBI_5801 |
| T38520 | 298-310 | Chemical | denotes | azithromycin | http://purl.obolibrary.org/obo/CHEBI_2955 |
| T79741 | 403-421 | Chemical | denotes | hydroxychloroquine | http://purl.obolibrary.org/obo/CHEBI_5801 |
| T49111 | 599-603 | Chemical | denotes | drug | http://purl.obolibrary.org/obo/CHEBI_23888 |
| T1213 | 632-655 | Chemical | denotes | lopinavir and ritonavir | http://purl.obolibrary.org/obo/CHEBI_145924 |
| T65 | 632-641 | Chemical | denotes | lopinavir | http://purl.obolibrary.org/obo/CHEBI_31781 |
| T77715 | 646-655 | Chemical | denotes | ritonavir | http://purl.obolibrary.org/obo/CHEBI_45409 |
| T37499 | 756-761 | Chemical | denotes | drugs | http://purl.obolibrary.org/obo/CHEBI_23888 |
| T29897 | 762-773 | Chemical | denotes | chloroquine | http://purl.obolibrary.org/obo/CHEBI_3638 |
| T19985 | 778-796 | Chemical | denotes | hydroxychloroquine | http://purl.obolibrary.org/obo/CHEBI_5801 |
| T22696 | 855-860 | Chemical | denotes | drugs | http://purl.obolibrary.org/obo/CHEBI_23888 |
| T79813 | 1032-1037 | Chemical | denotes | drugs | http://purl.obolibrary.org/obo/CHEBI_23888 |
| T69397 | 1256-1266 | Chemical | denotes | nucleoside | http://purl.obolibrary.org/obo/CHEBI_33838 |
| T20148 | 1416-1425 | Chemical | denotes | Lopinavir | http://purl.obolibrary.org/obo/CHEBI_31781 |
| T21128 | 1444-1454 | Chemical | denotes | inhibitors | http://purl.obolibrary.org/obo/CHEBI_35222 |
| T81696 | 1529-1539 | Chemical | denotes | inhibitors | http://purl.obolibrary.org/obo/CHEBI_35222 |
| T16278 | 1865-1879 | Chemical | denotes | hydrocortisone | http://purl.obolibrary.org/obo/CHEBI_17650 |
| T64734 | 1912-1930 | Chemical | denotes | methylprednisolone | http://purl.obolibrary.org/obo/CHEBI_6888 |
| T9447 | 2076-2085 | Chemical | denotes | Lopinavir | http://purl.obolibrary.org/obo/CHEBI_31781 |
| T79 | 2086-2095 | Chemical | denotes | ritonavir | http://purl.obolibrary.org/obo/CHEBI_45409 |
| T53974 | 2255-2265 | Chemical | denotes | interferon | http://purl.obolibrary.org/obo/CHEBI_52999 |
| T37213 | 2299-2302 | Chemical | denotes | DNA | http://purl.obolibrary.org/obo/CHEBI_16991 |
| T38671 | 2360-2369 | Chemical | denotes | Lopinavir | http://purl.obolibrary.org/obo/CHEBI_31781 |
| T55075 | 2370-2379 | Chemical | denotes | ritonavir | http://purl.obolibrary.org/obo/CHEBI_45409 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T121 | 135-141 | http://purl.obolibrary.org/obo/GO_0040007 | denotes | growth |
| T122 | 1276-1314 | http://purl.obolibrary.org/obo/GO_0045071 | denotes | inhibits the viral genomic replication |
| T123 | 1289-1314 | http://purl.obolibrary.org/obo/GO_0019079 | denotes | viral genomic replication |
| T124 | 1672-1680 | http://purl.obolibrary.org/obo/GO_0070265 | denotes | necrosis |
| T125 | 1672-1680 | http://purl.obolibrary.org/obo/GO_0019835 | denotes | necrosis |
| T126 | 1672-1680 | http://purl.obolibrary.org/obo/GO_0008219 | denotes | necrosis |
| T127 | 1672-1680 | http://purl.obolibrary.org/obo/GO_0001906 | denotes | necrosis |
| T128 | 2045-2060 | http://purl.obolibrary.org/obo/GO_0006955 | denotes | immune response |
| T129 | 2299-2312 | http://purl.obolibrary.org/obo/GO_0071897 | denotes | DNA synthesis |
| T130 | 2303-2312 | http://purl.obolibrary.org/obo/GO_0009058 | denotes | synthesis |
| T131 | 2442-2450 | http://purl.obolibrary.org/obo/GO_0070265 | denotes | necrosis |
| T132 | 2442-2450 | http://purl.obolibrary.org/obo/GO_0019835 | denotes | necrosis |
| T133 | 2442-2450 | http://purl.obolibrary.org/obo/GO_0008219 | denotes | necrosis |
| T134 | 2442-2450 | http://purl.obolibrary.org/obo/GO_0001906 | denotes | necrosis |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T440 | 0-142 | Sentence | denotes | According to the Chinese report, in-vitro treatment of SARS-CoV-2 with hydroxychloroquine had resulted in the inhibition of SARS-CoV-2 growth. |
| T441 | 143-462 | Sentence | denotes | Along with hydroxychloroquine, azithromycin was also administered at a dosage of 500 mg, the patients treated with a combination of hydroxychloroquine and azithromycin exhibited 100% cure and tested negative for PCR results; whereas, the patients treated with hydroxychloroquine alone exhibited only 57.1% success rate. |
| T442 | 463-590 | Sentence | denotes | This combinational therapy might be an approachable way to cure COVID-19 and needs to be tested over a large sample size [147]. |
| T443 | 591-695 | Sentence | denotes | Another drug combination, which includes lopinavir and ritonavir, had no in-vitro evidence for COVID-19. |
| T444 | 696-823 | Sentence | denotes | Also, the clinical trials are being carried out on malarial drugs chloroquine and hydroxychloroquine (represented in Table 2 ). |
| T445 | 824-902 | Sentence | denotes | Some scientists say that these drugs are not recommendable against SARS-CoV-2. |
| T446 | 903-1003 | Sentence | denotes | Since there are no scientific proofs available and it might be harmful, leading to heart arrhythmia. |
| T447 | 1004-1145 | Sentence | denotes | Table 2 Elucidating various drugs used to treat SARS-CoV, MERS-CoV, and SARS-CoV-2, along with their mechanism of action and adverse effects. |
| T448 | 1146-1152 | Sentence | denotes | S. no. |
| T449 | 1153-1222 | Sentence | denotes | Drug Effective against Mechanism of action Adverse effects References |
| T450 | 1223-1225 | Sentence | denotes | 1. |
| T451 | 1226-1412 | Sentence | denotes | Ribavirin SARS-CoV Anti-viral nucleoside analog – inhibits the viral genomic replication Anemia, hypocalcemia, hypomagnesemia, developed the risk of teratogenicity and bradycardia [118]. |
| T452 | 1413-1415 | Sentence | denotes | 2. |
| T453 | 1416-1497 | Sentence | denotes | Lopinavir SARS-CoV Protease inhibitors Diarrhea, nausea, vomiting, headache [122] |
| T454 | 1498-1500 | Sentence | denotes | 3. |
| T455 | 1501-1582 | Sentence | denotes | Ritonavir SARS-CoV Protease inhibitors Diarrhea, nausea, vomiting, headache [122] |
| T456 | 1583-1585 | Sentence | denotes | 4. |
| T457 | 1586-1705 | Sentence | denotes | Methylprednisolone SARS-CoV Anti-inflammatory effect The onset of diabetes, avascular necrosis, osteoporosis. [132,133] |
| T458 | 1706-1708 | Sentence | denotes | 5. |
| T459 | 1709-1816 | Sentence | denotes | Corticosteroids SARS-CoV Inhibits pro-inflammatory effects Aspergillosis and fungal superinfection [49,134] |
| T460 | 1817-1819 | Sentence | denotes | 6. |
| T461 | 1820-1970 | Sentence | denotes | Methylprednisolone (0.5–1 mg/kg) followed by hydrocortisone (100 mg/8 h) and pulse doses of methylprednisolone (0.5 g for 3 d) Lung diseases – – [124] |
| T462 | 1971-1973 | Sentence | denotes | 7. |
| T463 | 1974-2072 | Sentence | denotes | Convalescent plasma SARS-CoV, MERS-CoV, SARS-CoV-2 Adaptive or passive immune response – [135,139] |
| T464 | 2073-2075 | Sentence | denotes | 8. |
| T465 | 2076-2241 | Sentence | denotes | Lopinavir/ritonavir MERS-CoV, SARS-CoV-2 Not effective against MERS, anti-viral therapy for pneumonia caused by SARS-CoV-2 Diarrhea, nausea, vomiting, headache [140] |
| T466 | 2242-2244 | Sentence | denotes | 9. |
| T467 | 2245-2355 | Sentence | denotes | Pegylated interferon-α Hepatitis-C, MERS-CoV Inhibits DNA synthesis Diarrhea, nausea, vomiting, headache [140] |
| T468 | 2356-2359 | Sentence | denotes | 10. |
| T469 | 2360-2533 | Sentence | denotes | Lopinavir/ritonavir and IFN-β MERS-CoV Improves pulmonary, reduce viral load, and necrosis in lungs and extrapulmonary tissues Diarrhea, nausea, vomiting, headache [143,144] |
| T470 | 2534-2537 | Sentence | denotes | 11. |
| T471 | 2538-2747 | Sentence | denotes | Hydroxychloroquine SARS-CoV-2, Malaria Blocks maturation of endosome, maturation and its function by inhibiting the release of virions in the infected cell Diarrhea, nausea, vomiting, headache, dizziness [112] |
LitCovid-PD-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T279 | 992-1002 | Phenotype | denotes | arrhythmia | http://purl.obolibrary.org/obo/HP_0011675 |
| T280 | 1315-1321 | Phenotype | denotes | Anemia | http://purl.obolibrary.org/obo/HP_0001903 |
| T281 | 1323-1335 | Phenotype | denotes | hypocalcemia | http://purl.obolibrary.org/obo/HP_0002901 |
| T282 | 1337-1351 | Phenotype | denotes | hypomagnesemia | http://purl.obolibrary.org/obo/HP_0002917 |
| T283 | 1394-1405 | Phenotype | denotes | bradycardia | http://purl.obolibrary.org/obo/HP_0001662 |
| T284 | 1455-1463 | Phenotype | denotes | Diarrhea | http://purl.obolibrary.org/obo/HP_0002014 |
| T285 | 1465-1481 | Phenotype | denotes | nausea, vomiting | http://purl.obolibrary.org/obo/HP_0002017 |
| T286 | 1483-1491 | Phenotype | denotes | headache | http://purl.obolibrary.org/obo/HP_0002315 |
| T287 | 1540-1548 | Phenotype | denotes | Diarrhea | http://purl.obolibrary.org/obo/HP_0002014 |
| T288 | 1550-1566 | Phenotype | denotes | nausea, vomiting | http://purl.obolibrary.org/obo/HP_0002017 |
| T289 | 1568-1576 | Phenotype | denotes | headache | http://purl.obolibrary.org/obo/HP_0002315 |
| T290 | 1662-1680 | Phenotype | denotes | avascular necrosis | http://purl.obolibrary.org/obo/HP_0010885 |
| T291 | 1682-1694 | Phenotype | denotes | osteoporosis | http://purl.obolibrary.org/obo/HP_0000939 |
| T292 | 1947-1960 | Phenotype | denotes | Lung diseases | http://purl.obolibrary.org/obo/HP_0002088 |
| T293 | 2168-2177 | Phenotype | denotes | pneumonia | http://purl.obolibrary.org/obo/HP_0002090 |
| T294 | 2199-2207 | Phenotype | denotes | Diarrhea | http://purl.obolibrary.org/obo/HP_0002014 |
| T295 | 2209-2225 | Phenotype | denotes | nausea, vomiting | http://purl.obolibrary.org/obo/HP_0002017 |
| T296 | 2227-2235 | Phenotype | denotes | headache | http://purl.obolibrary.org/obo/HP_0002315 |
| T297 | 2268-2277 | Phenotype | denotes | Hepatitis | http://purl.obolibrary.org/obo/HP_0012115 |
| T298 | 2313-2321 | Phenotype | denotes | Diarrhea | http://purl.obolibrary.org/obo/HP_0002014 |
| T299 | 2323-2339 | Phenotype | denotes | nausea, vomiting | http://purl.obolibrary.org/obo/HP_0002017 |
| T300 | 2341-2349 | Phenotype | denotes | headache | http://purl.obolibrary.org/obo/HP_0002315 |
| T301 | 2487-2495 | Phenotype | denotes | Diarrhea | http://purl.obolibrary.org/obo/HP_0002014 |
| T302 | 2497-2513 | Phenotype | denotes | nausea, vomiting | http://purl.obolibrary.org/obo/HP_0002017 |
| T303 | 2515-2523 | Phenotype | denotes | headache | http://purl.obolibrary.org/obo/HP_0002315 |
| T304 | 2694-2702 | Phenotype | denotes | Diarrhea | http://purl.obolibrary.org/obo/HP_0002014 |
| T305 | 2704-2720 | Phenotype | denotes | nausea, vomiting | http://purl.obolibrary.org/obo/HP_0002017 |
| T306 | 2722-2730 | Phenotype | denotes | headache | http://purl.obolibrary.org/obo/HP_0002315 |
| T307 | 2732-2741 | Phenotype | denotes | dizziness | http://purl.obolibrary.org/obo/HP_0002321 |
2_test
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 32450165-32205204-66451114 | 585-588 | 32205204 | denotes | 147 |
| 32450165-32066541-66451116 | 1578-1581 | 32066541 | denotes | 122 |
| 32450165-15650220-66451117 | 1697-1700 | 15650220 | denotes | 132 |
| 32450165-15272286-66451118 | 1809-1811 | 15272286 | denotes | 49 |
| 32450165-14985565-66451119 | 2064-2067 | 14985565 | denotes | 135 |
| 32450165-14523782-66451120 | 2068-2071 | 14523782 | denotes | 139 |
| 32450165-16183666-66451121 | 2525-2528 | 16183666 | denotes | 143 |
| 32450165-15214887-66451122 | 2529-2532 | 15214887 | denotes | 144 |