PMC:7243768 / 61150-63897 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7243768","sourcedb":"PMC","sourceid":"7243768","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7243768","text":"According to the Chinese report, in-vitro treatment of SARS-CoV-2 with hydroxychloroquine had resulted in the inhibition of SARS-CoV-2 growth. Along with hydroxychloroquine, azithromycin was also administered at a dosage of 500 mg, the patients treated with a combination of hydroxychloroquine and azithromycin exhibited 100% cure and tested negative for PCR results; whereas, the patients treated with hydroxychloroquine alone exhibited only 57.1% success rate. This combinational therapy might be an approachable way to cure COVID-19 and needs to be tested over a large sample size [147]. Another drug combination, which includes lopinavir and ritonavir, had no in-vitro evidence for COVID-19. Also, the clinical trials are being carried out on malarial drugs chloroquine and hydroxychloroquine (represented in Table 2 ). Some scientists say that these drugs are not recommendable against SARS-CoV-2. Since there are no scientific proofs available and it might be harmful, leading to heart arrhythmia.\nTable 2 Elucidating various drugs used to treat SARS-CoV, MERS-CoV, and SARS-CoV-2, along with their mechanism of action and adverse effects.\nS. no. Drug Effective against Mechanism of action Adverse effects References\n1. Ribavirin SARS-CoV Anti-viral nucleoside analog – inhibits the viral genomic replication Anemia, hypocalcemia, hypomagnesemia, developed the risk of teratogenicity and bradycardia [118].\n2. Lopinavir SARS-CoV Protease inhibitors Diarrhea, nausea, vomiting, headache [122]\n3. Ritonavir SARS-CoV Protease inhibitors Diarrhea, nausea, vomiting, headache [122]\n4. Methylprednisolone SARS-CoV Anti-inflammatory effect The onset of diabetes, avascular necrosis, osteoporosis. [132,133]\n5. Corticosteroids SARS-CoV Inhibits pro-inflammatory effects Aspergillosis and fungal superinfection [49,134]\n6. Methylprednisolone (0.5–1 mg/kg) followed by hydrocortisone (100 mg/8 h) and pulse doses of methylprednisolone (0.5 g for 3 d) Lung diseases – – [124]\n7. Convalescent plasma SARS-CoV, MERS-CoV, SARS-CoV-2 Adaptive or passive immune response – [135,139]\n8. Lopinavir/ritonavir MERS-CoV, SARS-CoV-2 Not effective against MERS, anti-viral therapy for pneumonia caused by SARS-CoV-2 Diarrhea, nausea, vomiting, headache [140]\n9. Pegylated interferon-α Hepatitis-C, MERS-CoV Inhibits DNA synthesis Diarrhea, nausea, vomiting, headache [140]\n10. Lopinavir/ritonavir and IFN-β MERS-CoV Improves pulmonary, reduce viral load, and necrosis in lungs and extrapulmonary tissues Diarrhea, nausea, vomiting, headache [143,144]\n11. Hydroxychloroquine SARS-CoV-2, Malaria Blocks maturation of endosome, maturation and its function by inhibiting the release of virions in the infected cell Diarrhea, nausea, vomiting, headache, dizziness 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