PMC:7239617 / 1124-1927 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7239617","sourcedb":"PMC","sourceid":"7239617","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7239617","text":"Parallelling what has been reported in influenza patients, we designed this prospective observational study to investigate IPA risk in critically ill patients with COVID-19. The patients were classified by means of the EORTC-MSG criteria5 (if immunocompromised) or the influenza-associated IPA criteria4 combined with serum β-D-glucan and quantitative real-time PCR (qPCR)7 done in the serum or pulmonary specimens (if non-immunocompromised). Putative IPA was considered if Aspergillus spp were identified in BAL culture; or if two of the following conditions were met (ie, presence of Aspergillus spp in bronchial aspiration [BA] culture; positive Aspergillus fumigatus qPCR in BAL, BA, or serum;8 galactomannan index \u003e0·8 in BAL;5 galactomannan index \u003e0·5 in serum; and β-D-glucan \u003e80 pg/mL in serum).","tracks":[{"project":"LitCovid-PubTator","denotations":[{"id":"55","span":{"begin":49,"end":57},"obj":"Species"},{"id":"56","span":{"begin":150,"end":158},"obj":"Species"},{"id":"57","span":{"begin":178,"end":186},"obj":"Species"},{"id":"58","span":{"begin":649,"end":670},"obj":"Species"},{"id":"59","span":{"begin":474,"end":485},"obj":"Species"},{"id":"60","span":{"begin":586,"end":597},"obj":"Species"},{"id":"61","span":{"begin":324,"end":334},"obj":"Chemical"},{"id":"62","span":{"begin":684,"end":686},"obj":"Chemical"},{"id":"66","span":{"begin":135,"end":149},"obj":"Disease"},{"id":"67","span":{"begin":164,"end":172},"obj":"Disease"}],"attributes":[{"id":"A55","pred":"tao:has_database_id","subj":"55","obj":"Tax:9606"},{"id":"A56","pred":"tao:has_database_id","subj":"56","obj":"Tax:9606"},{"id":"A57","pred":"tao:has_database_id","subj":"57","obj":"Tax:9606"},{"id":"A58","pred":"tao:has_database_id","subj":"58","obj":"Tax:746128"},{"id":"A59","pred":"tao:has_database_id","subj":"59","obj":"Tax:746128"},{"id":"A60","pred":"tao:has_database_id","subj":"60","obj":"Tax:746128"},{"id":"A66","pred":"tao:has_database_id","subj":"66","obj":"MESH:D016638"},{"id":"A67","pred":"tao:has_database_id","subj":"67","obj":"MESH:C000657245"},{"subj":"55","pred":"source","obj":"LitCovid-PubTator"},{"subj":"56","pred":"source","obj":"LitCovid-PubTator"},{"subj":"57","pred":"source","obj":"LitCovid-PubTator"},{"subj":"58","pred":"source","obj":"LitCovid-PubTator"},{"subj":"59","pred":"source","obj":"LitCovid-PubTator"},{"subj":"60","pred":"source","obj":"LitCovid-PubTator"},{"subj":"61","pred":"source","obj":"LitCovid-PubTator"},{"subj":"62","pred":"source","obj":"LitCovid-PubTator"},{"subj":"66","pred":"source","obj":"LitCovid-PubTator"},{"subj":"67","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T2","span":{"begin":318,"end":323},"obj":"Body_part"},{"id":"T3","span":{"begin":386,"end":391},"obj":"Body_part"},{"id":"T4","span":{"begin":691,"end":696},"obj":"Body_part"},{"id":"T5","span":{"begin":761,"end":766},"obj":"Body_part"},{"id":"T6","span":{"begin":796,"end":801},"obj":"Body_part"}],"attributes":[{"id":"A2","pred":"fma_id","subj":"T2","obj":"http://purl.org/sig/ont/fma/fma63083"},{"id":"A3","pred":"fma_id","subj":"T3","obj":"http://purl.org/sig/ont/fma/fma63083"},{"id":"A4","pred":"fma_id","subj":"T4","obj":"http://purl.org/sig/ont/fma/fma63083"},{"id":"A5","pred":"fma_id","subj":"T5","obj":"http://purl.org/sig/ont/fma/fma63083"},{"id":"A6","pred":"fma_id","subj":"T6","obj":"http://purl.org/sig/ont/fma/fma63083"},{"subj":"T2","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T3","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T4","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T5","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T6","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T2","span":{"begin":318,"end":323},"obj":"Body_part"},{"id":"T3","span":{"begin":386,"end":391},"obj":"Body_part"},{"id":"T4","span":{"begin":691,"end":696},"obj":"Body_part"},{"id":"T5","span":{"begin":761,"end":766},"obj":"Body_part"},{"id":"T6","span":{"begin":796,"end":801},"obj":"Body_part"}],"attributes":[{"id":"A2","pred":"uberon_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/UBERON_0001977"},{"id":"A3","pred":"uberon_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/UBERON_0001977"},{"id":"A4","pred":"uberon_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/UBERON_0001977"},{"id":"A5","pred":"uberon_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/UBERON_0001977"},{"id":"A6","pred":"uberon_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/UBERON_0001977"},{"subj":"T2","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T3","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T4","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T5","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T6","pred":"source","obj":"LitCovid-PD-UBERON"}]},{"project":"LitCovid-PD-HP","denotations":[{"id":"T7","span":{"begin":123,"end":126},"obj":"Phenotype"},{"id":"T8","span":{"begin":290,"end":293},"obj":"Phenotype"},{"id":"T9","span":{"begin":452,"end":455},"obj":"Phenotype"},{"id":"T10","span":{"begin":615,"end":625},"obj":"Phenotype"}],"attributes":[{"id":"A7","pred":"hp_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/HP_0020103"},{"id":"A8","pred":"hp_id","subj":"T8","obj":"http://purl.obolibrary.org/obo/HP_0020103"},{"id":"A9","pred":"hp_id","subj":"T9","obj":"http://purl.obolibrary.org/obo/HP_0020103"},{"id":"A10","pred":"hp_id","subj":"T10","obj":"http://purl.obolibrary.org/obo/HP_0002835"},{"subj":"T7","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T8","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T9","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T10","pred":"source","obj":"LitCovid-PD-HP"}]},{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T13","span":{"begin":39,"end":48},"obj":"Disease"},{"id":"T14","span":{"begin":164,"end":172},"obj":"Disease"},{"id":"T15","span":{"begin":269,"end":278},"obj":"Disease"}],"attributes":[{"id":"A13","pred":"mondo_id","subj":"T13","obj":"http://purl.obolibrary.org/obo/MONDO_0005812"},{"id":"A14","pred":"mondo_id","subj":"T14","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A15","pred":"mondo_id","subj":"T15","obj":"http://purl.obolibrary.org/obo/MONDO_0005812"},{"subj":"T13","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T14","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T15","pred":"source","obj":"LitCovid-PD-MONDO"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T4","span":{"begin":18,"end":21},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T5","span":{"begin":787,"end":789},"obj":"http://purl.obolibrary.org/obo/CLO_0008426"}],"attributes":[{"subj":"T4","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T5","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T11","span":{"begin":123,"end":126},"obj":"Chemical"},{"id":"T13","span":{"begin":225,"end":228},"obj":"Chemical"},{"id":"T15","span":{"begin":290,"end":293},"obj":"Chemical"},{"id":"T17","span":{"begin":328,"end":334},"obj":"Chemical"},{"id":"T18","span":{"begin":452,"end":455},"obj":"Chemical"},{"id":"T20","span":{"begin":509,"end":512},"obj":"Chemical"},{"id":"T21","span":{"begin":679,"end":682},"obj":"Chemical"},{"id":"T22","span":{"begin":699,"end":712},"obj":"Chemical"},{"id":"T23","span":{"begin":727,"end":730},"obj":"Chemical"},{"id":"T24","span":{"begin":733,"end":746},"obj":"Chemical"},{"id":"T25","span":{"begin":776,"end":782},"obj":"Chemical"}],"attributes":[{"id":"A11","pred":"chebi_id","subj":"T11","obj":"http://purl.obolibrary.org/obo/CHEBI_17824"},{"id":"A12","pred":"chebi_id","subj":"T11","obj":"http://purl.obolibrary.org/obo/CHEBI_30802"},{"id":"A13","pred":"chebi_id","subj":"T13","obj":"http://purl.obolibrary.org/obo/CHEBI_64220"},{"id":"A14","pred":"chebi_id","subj":"T13","obj":"http://purl.obolibrary.org/obo/CHEBI_64243"},{"id":"A15","pred":"chebi_id","subj":"T15","obj":"http://purl.obolibrary.org/obo/CHEBI_17824"},{"id":"A16","pred":"chebi_id","subj":"T15","obj":"http://purl.obolibrary.org/obo/CHEBI_30802"},{"id":"A17","pred":"chebi_id","subj":"T17","obj":"http://purl.obolibrary.org/obo/CHEBI_37163"},{"id":"A18","pred":"chebi_id","subj":"T18","obj":"http://purl.obolibrary.org/obo/CHEBI_17824"},{"id":"A19","pred":"chebi_id","subj":"T18","obj":"http://purl.obolibrary.org/obo/CHEBI_30802"},{"id":"A20","pred":"chebi_id","subj":"T20","obj":"http://purl.obolibrary.org/obo/CHEBI_64198"},{"id":"A21","pred":"chebi_id","subj":"T21","obj":"http://purl.obolibrary.org/obo/CHEBI_64198"},{"id":"A22","pred":"chebi_id","subj":"T22","obj":"http://purl.obolibrary.org/obo/CHEBI_27680"},{"id":"A23","pred":"chebi_id","subj":"T23","obj":"http://purl.obolibrary.org/obo/CHEBI_64198"},{"id":"A24","pred":"chebi_id","subj":"T24","obj":"http://purl.obolibrary.org/obo/CHEBI_27680"},{"id":"A25","pred":"chebi_id","subj":"T25","obj":"http://purl.obolibrary.org/obo/CHEBI_37163"},{"subj":"T11","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T13","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T15","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T17","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T18","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T20","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T21","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T22","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T23","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T24","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T25","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-PD-GlycoEpitope","denotations":[{"id":"T2","span":{"begin":699,"end":712},"obj":"GlycoEpitope"},{"id":"T3","span":{"begin":733,"end":746},"obj":"GlycoEpitope"}],"attributes":[{"id":"A2","pred":"glyco_epitope_db_id","subj":"T2","obj":"http://www.glycoepitope.jp/epitopes/EP0510"},{"id":"A3","pred":"glyco_epitope_db_id","subj":"T3","obj":"http://www.glycoepitope.jp/epitopes/EP0510"},{"subj":"T2","pred":"source","obj":"LitCovid-PD-GlycoEpitope"},{"subj":"T3","pred":"source","obj":"LitCovid-PD-GlycoEpitope"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T3","span":{"begin":0,"end":173},"obj":"Sentence"},{"id":"T4","span":{"begin":174,"end":442},"obj":"Sentence"},{"id":"T5","span":{"begin":443,"end":803},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T3","pred":"source","obj":"LitCovid-sentences"},{"subj":"T4","pred":"source","obj":"LitCovid-sentences"},{"subj":"T5","pred":"source","obj":"LitCovid-sentences"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PubTator","color":"#95ec93","default":true},{"id":"LitCovid-PD-FMA-UBERON","color":"#ec93af"},{"id":"LitCovid-PD-UBERON","color":"#93c9ec"},{"id":"LitCovid-PD-HP","color":"#e3ec93"},{"id":"LitCovid-PD-MONDO","color":"#db93ec"},{"id":"LitCovid-PD-CLO","color":"#93ecc1"},{"id":"LitCovid-PD-CHEBI","color":"#eca793"},{"id":"LitCovid-PD-GlycoEpitope","color":"#9398ec"},{"id":"LitCovid-sentences","color":"#b3ec93"}]}]}}