PMC:7190487 / 2312-2873 JSONTXT

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{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7190487","sourcedb":"PMC","sourceid":"7190487","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7190487","text":"Nonetheless, once the virus is inside, there is a downregulation of ACE2 receptors. This in turn leads to an imbalance in the renin-angiotensin-aldosterone system (RAS) promoting the deleterious effects of its pro-inflammatory and pro-fibrotic arm, further giving rise to the lethal cardio-pulmonary complications [10]. By upregulating ACE2, the imbalance in RAS could be averted. Hence, metformin would not only prevent the entry of SARS-CoV-2 as described above, but also prevent the detrimental sequelae by causing activation of ACE2 through 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