PMC:7190487 / 2312-2873
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T14 | 244-247 | Body_part | denotes | arm | http://purl.org/sig/ont/fma/fma24890 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T5 | 244-247 | Body_part | denotes | arm | http://purl.obolibrary.org/obo/UBERON_0001460 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T18 | 434-442 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T35 | 22-27 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T36 | 48-49 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T37 | 244-247 | http://www.ebi.ac.uk/efo/EFO_0001410 | denotes | arm |
| T38 | 518-528 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activation |
| T39 | 550-560 | http://purl.obolibrary.org/obo/SO_0000418 | denotes | signalling |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T36 | 132-143 | Chemical | denotes | angiotensin | http://purl.obolibrary.org/obo/CHEBI_48433 |
| T37 | 144-155 | Chemical | denotes | aldosterone | http://purl.obolibrary.org/obo/CHEBI_27584|http://purl.obolibrary.org/obo/CHEBI_30834 |
| T39 | 164-167 | Chemical | denotes | RAS | http://purl.obolibrary.org/obo/CHEBI_63620 |
| T40 | 359-362 | Chemical | denotes | RAS | http://purl.obolibrary.org/obo/CHEBI_63620 |
| T41 | 388-397 | Chemical | denotes | metformin | http://purl.obolibrary.org/obo/CHEBI_6801 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T23 | 545-549 | http://purl.obolibrary.org/obo/GO_0050405 | denotes | AMPK |
| T24 | 545-549 | http://purl.obolibrary.org/obo/GO_0047322 | denotes | AMPK |
| T25 | 545-549 | http://purl.obolibrary.org/obo/GO_0004691 | denotes | AMPK |
| T26 | 550-560 | http://purl.obolibrary.org/obo/GO_0023052 | denotes | signalling |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T22 | 0-83 | Sentence | denotes | Nonetheless, once the virus is inside, there is a downregulation of ACE2 receptors. |
| T23 | 84-319 | Sentence | denotes | This in turn leads to an imbalance in the renin-angiotensin-aldosterone system (RAS) promoting the deleterious effects of its pro-inflammatory and pro-fibrotic arm, further giving rise to the lethal cardio-pulmonary complications [10]. |
| T24 | 320-380 | Sentence | denotes | By upregulating ACE2, the imbalance in RAS could be averted. |
| T25 | 381-561 | Sentence | denotes | Hence, metformin would not only prevent the entry of SARS-CoV-2 as described above, but also prevent the detrimental sequelae by causing activation of ACE2 through AMPK-signalling. |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 117 | 68-72 | Gene | denotes | ACE2 | Gene:59272 |
| 118 | 336-340 | Gene | denotes | ACE2 | Gene:59272 |
| 119 | 532-536 | Gene | denotes | ACE2 | Gene:59272 |
| 120 | 545-549 | Gene | denotes | AMPK | Gene:5563 |
| 121 | 434-444 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 122 | 144-155 | Chemical | denotes | aldosterone | MESH:D000450 |
| 123 | 388-397 | Chemical | denotes | metformin | MESH:D008687 |