PMC:7190487 / 2312-2873 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T14","span":{"begin":244,"end":247},"obj":"Body_part"}],"attributes":[{"id":"A14","pred":"fma_id","subj":"T14","obj":"http://purl.org/sig/ont/fma/fma24890"}],"text":"Nonetheless, once the virus is inside, there is a downregulation of ACE2 receptors. This in turn leads to an imbalance in the renin-angiotensin-aldosterone system (RAS) promoting the deleterious effects of its pro-inflammatory and pro-fibrotic arm, further giving rise to the lethal cardio-pulmonary complications [10]. By upregulating ACE2, the imbalance in RAS could be averted. Hence, metformin would not only prevent the entry of SARS-CoV-2 as described above, but also prevent the detrimental sequelae by causing activation of ACE2 through AMPK-signalling."}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T5","span":{"begin":244,"end":247},"obj":"Body_part"}],"attributes":[{"id":"A5","pred":"uberon_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/UBERON_0001460"}],"text":"Nonetheless, once the virus is inside, there is a downregulation of ACE2 receptors. This in turn leads to an imbalance in the renin-angiotensin-aldosterone system (RAS) promoting the deleterious effects of its pro-inflammatory and pro-fibrotic arm, further giving rise to the lethal cardio-pulmonary complications [10]. By upregulating ACE2, the imbalance in RAS could be averted. Hence, metformin would not only prevent the entry of SARS-CoV-2 as described above, but also prevent the detrimental sequelae by causing activation of ACE2 through AMPK-signalling."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T18","span":{"begin":434,"end":442},"obj":"Disease"}],"attributes":[{"id":"A18","pred":"mondo_id","subj":"T18","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"}],"text":"Nonetheless, once the virus is inside, there is a downregulation of ACE2 receptors. This in turn leads to an imbalance in the renin-angiotensin-aldosterone system (RAS) promoting the deleterious effects of its pro-inflammatory and pro-fibrotic arm, further giving rise to the lethal cardio-pulmonary complications [10]. By upregulating ACE2, the imbalance in RAS could be averted. Hence, metformin would not only prevent the entry of SARS-CoV-2 as described above, but also prevent the detrimental sequelae by causing activation of ACE2 through AMPK-signalling."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T35","span":{"begin":22,"end":27},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T36","span":{"begin":48,"end":49},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T37","span":{"begin":244,"end":247},"obj":"http://www.ebi.ac.uk/efo/EFO_0001410"},{"id":"T38","span":{"begin":518,"end":528},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T39","span":{"begin":550,"end":560},"obj":"http://purl.obolibrary.org/obo/SO_0000418"}],"text":"Nonetheless, once the virus is inside, there is a downregulation of ACE2 receptors. This in turn leads to an imbalance in the renin-angiotensin-aldosterone system (RAS) promoting the deleterious effects of its pro-inflammatory and pro-fibrotic arm, further giving rise to the lethal cardio-pulmonary complications [10]. By upregulating ACE2, the imbalance in RAS could be averted. Hence, metformin would not only prevent the entry of SARS-CoV-2 as described above, but also prevent the detrimental sequelae by causing activation of ACE2 through AMPK-signalling."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T36","span":{"begin":132,"end":143},"obj":"Chemical"},{"id":"T37","span":{"begin":144,"end":155},"obj":"Chemical"},{"id":"T39","span":{"begin":164,"end":167},"obj":"Chemical"},{"id":"T40","span":{"begin":359,"end":362},"obj":"Chemical"},{"id":"T41","span":{"begin":388,"end":397},"obj":"Chemical"}],"attributes":[{"id":"A36","pred":"chebi_id","subj":"T36","obj":"http://purl.obolibrary.org/obo/CHEBI_48433"},{"id":"A37","pred":"chebi_id","subj":"T37","obj":"http://purl.obolibrary.org/obo/CHEBI_27584"},{"id":"A38","pred":"chebi_id","subj":"T37","obj":"http://purl.obolibrary.org/obo/CHEBI_30834"},{"id":"A39","pred":"chebi_id","subj":"T39","obj":"http://purl.obolibrary.org/obo/CHEBI_63620"},{"id":"A40","pred":"chebi_id","subj":"T40","obj":"http://purl.obolibrary.org/obo/CHEBI_63620"},{"id":"A41","pred":"chebi_id","subj":"T41","obj":"http://purl.obolibrary.org/obo/CHEBI_6801"}],"text":"Nonetheless, once the virus is inside, there is a downregulation of ACE2 receptors. This in turn leads to an imbalance in the renin-angiotensin-aldosterone system (RAS) promoting the deleterious effects of its pro-inflammatory and pro-fibrotic arm, further giving rise to the lethal cardio-pulmonary complications [10]. By upregulating ACE2, the imbalance in RAS could be averted. Hence, metformin would not only prevent the entry of SARS-CoV-2 as described above, but also prevent the detrimental sequelae by causing activation of ACE2 through AMPK-signalling."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T23","span":{"begin":545,"end":549},"obj":"http://purl.obolibrary.org/obo/GO_0050405"},{"id":"T24","span":{"begin":545,"end":549},"obj":"http://purl.obolibrary.org/obo/GO_0047322"},{"id":"T25","span":{"begin":545,"end":549},"obj":"http://purl.obolibrary.org/obo/GO_0004691"},{"id":"T26","span":{"begin":550,"end":560},"obj":"http://purl.obolibrary.org/obo/GO_0023052"}],"text":"Nonetheless, once the virus is inside, there is a downregulation of ACE2 receptors. This in turn leads to an imbalance in the renin-angiotensin-aldosterone system (RAS) promoting the deleterious effects of its pro-inflammatory and pro-fibrotic arm, further giving rise to the lethal cardio-pulmonary complications [10]. By upregulating ACE2, the imbalance in RAS could be averted. Hence, metformin would not only prevent the entry of SARS-CoV-2 as described above, but also prevent the detrimental sequelae by causing activation of ACE2 through AMPK-signalling."}

{"project":"LitCovid-sentences","denotations":[{"id":"T22","span":{"begin":0,"end":83},"obj":"Sentence"},{"id":"T23","span":{"begin":84,"end":319},"obj":"Sentence"},{"id":"T24","span":{"begin":320,"end":380},"obj":"Sentence"},{"id":"T25","span":{"begin":381,"end":561},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Nonetheless, once the virus is inside, there is a downregulation of ACE2 receptors. This in turn leads to an imbalance in the renin-angiotensin-aldosterone system (RAS) promoting the deleterious effects of its pro-inflammatory and pro-fibrotic arm, further giving rise to the lethal cardio-pulmonary complications [10]. By upregulating ACE2, the imbalance in RAS could be averted. Hence, metformin would not only prevent the entry of SARS-CoV-2 as described above, but also prevent the detrimental sequelae by causing activation of ACE2 through AMPK-signalling."}

{"project":"LitCovid-PubTator","denotations":[{"id":"117","span":{"begin":68,"end":72},"obj":"Gene"},{"id":"118","span":{"begin":336,"end":340},"obj":"Gene"},{"id":"119","span":{"begin":532,"end":536},"obj":"Gene"},{"id":"120","span":{"begin":545,"end":549},"obj":"Gene"},{"id":"121","span":{"begin":434,"end":444},"obj":"Species"},{"id":"122","span":{"begin":144,"end":155},"obj":"Chemical"},{"id":"123","span":{"begin":388,"end":397},"obj":"Chemical"}],"attributes":[{"id":"A117","pred":"tao:has_database_id","subj":"117","obj":"Gene:59272"},{"id":"A118","pred":"tao:has_database_id","subj":"118","obj":"Gene:59272"},{"id":"A119","pred":"tao:has_database_id","subj":"119","obj":"Gene:59272"},{"id":"A120","pred":"tao:has_database_id","subj":"120","obj":"Gene:5563"},{"id":"A121","pred":"tao:has_database_id","subj":"121","obj":"Tax:2697049"},{"id":"A122","pred":"tao:has_database_id","subj":"122","obj":"MESH:D000450"},{"id":"A123","pred":"tao:has_database_id","subj":"123","obj":"MESH:D008687"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Nonetheless, once the virus is inside, there is a downregulation of ACE2 receptors. This in turn leads to an imbalance in the renin-angiotensin-aldosterone system (RAS) promoting the deleterious effects of its pro-inflammatory and pro-fibrotic arm, further giving rise to the lethal cardio-pulmonary complications [10]. By upregulating ACE2, the imbalance in RAS could be averted. Hence, metformin would not only prevent the entry of SARS-CoV-2 as described above, but also prevent the detrimental sequelae by causing activation of ACE2 through AMPK-signalling."}