test_HZAU_BioNLP  

Documents (27) JSON TSV

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PubMed 10075646 The biological and pathological function of the presenilin-1 Deltaexon 9 mutation is independent of its defect to undergo proteolytic processing. The two homologous presenilins are key factors for the 1.71 KB 2015-11-03 25 0 2021-07-12
PubMed 10545183 Amyloidogenic function of the Alzheimer's disease-associated presenilin 1 in the absence of endoproteolysis. Alzheimer's disease (AD) is characterized by the invariant accumulation of senile plaques p 1.77 KB 2015-11-21 3 0 2021-07-12
PubMed 10899436 Tau mutations in frontotemporal dementia FTDP-17 and their relevance for Alzheimer's disease. Alzheimer's disease is characterised by the degeneration of selected populations of nerve cells that devel 1.32 KB 2015-11-15 16 1 2021-07-12
PubMed 11447840 Tau gene mutations and neurodegeneration. Abundant neurofibrillary lesions made of the microtubule-associated protein tau constitute a defining neuropathological characteristic of Alzheimer's disease. 1.75 KB 2015-11-17 3 1 2021-07-12
PubMed 11906199 Generation of amyloid beta protein from a presenilin-1 and betaAPP complex. Presenilin-1 (PS1) is a causative gene in early onset familial Alzheimer's disease (FAD). FAD-linked mutant PS1s significant 1.03 KB 2015-11-22 1 1 2021-07-12
PubMed 11959461 FAD-linked mutations in presenilin 1 alter the length of Abeta peptides derived from betaAPP transmembrane domain mutants. gamma-Secretase is an enzymatic activity responsible for the final cleavage o 1.45 KB 2015-11-22 12 1 2021-07-12
PubMed 15006708 Fibroblasts from FAD-linked presenilin 1 mutations display a normal unfolded protein response but overproduce Abeta42 in response to tunicamycin. Many patients affected by early onset familial Alzheim 1.12 KB 2015-11-18 4 2 2021-07-12
PubMed 15192323 APP induces neuronal apoptosis through APP-BP1-mediated downregulation of beta-catenin. Alzheimer's disease (AD) is a neurodegenerative disease associated with progressive dementia. This mini-review f 861 Bytes 2015-11-22 2 9 2021-07-12
PubMed 15192701 PS1 activates PI3K thus inhibiting GSK-3 activity and tau overphosphorylation: effects of FAD mutations. Phosphatidylinositol 3-kinase (PI3K) promotes cell survival and communication by activating its 1.4 KB 2015-11-19 3 4 2021-07-12
PubMed 15992373 Familial Alzheimer's disease mutations inhibit gamma-secretase-mediated liberation of beta-amyloid precursor protein carboxy-terminal fragment. Cleavage of the beta-secretase processed beta-amyloid pr 1.51 KB 2015-11-19 3 8 2021-07-12