PubMed:6094871 JSONTXT 10 Projects

[Clinical evaluation of sulbactam/cefoperazone for infections in the field of obstetrics and gynecology]. A daily dose of 2 or 4 grams of sulbactam/cefoperazone (SBT/CPZ) by drip infusion was given to 12 patients with gyneco-obstetrical infections and the results were following: The clinical effect was judged excellent in 2 cases, good in 9 cases and poor in 1 case, and the effective rate was 91.7%. Except for Streptococcus faecalis, the bacteriological effect was sufficient. A good effect was also seen in Pseudomonas cepacia resistant organism to other cephem antibiotics. Diarrhea was observed in 1 patient, and increases of GOT and GPT, possibly attributable to concomitantly used anticancer agent, were detected in another patient. In conclusion, SBT/CPZ with a 91.7% of efficacy rate, was useful in infections caused by beta-lactamase producing organisms and, thus, a useful agent for gyneco-obstetrical infections.