| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T1 |
0-100 |
Sentence |
denotes |
Glucuronyl C5-epimerase is crucial for epithelial cell maturation during embryonic lung development. |
| T2 |
101-320 |
Sentence |
denotes |
Glucuronyl C5-epimerase (Hsepi) is a key enzyme in the biosynthesis of heparan sulfate that is a sulfated polysaccharide expressed on the cell surface and in the extracellular matrix of alveolar walls and blood vessels. |
| T3 |
321-453 |
Sentence |
denotes |
Targeted interruption of the Hsepi gene, Glce, in mice resulted in neonatal lethality, which is most likely due to lung atelectasis. |
| T4 |
454-544 |
Sentence |
denotes |
In this study, we examined the potential mechanisms behind the defect in lung development. |
| T5 |
545-682 |
Sentence |
denotes |
Histological analysis of the lungs from embryos revealed no difference in the morphology between wildtype and mutant animals up to E16.5. |
| T6 |
683-811 |
Sentence |
denotes |
This suggests that the initial events leading to formation of the lung primordium and branching morphogenesis are not disturbed. |
| T7 |
812-979 |
Sentence |
denotes |
However, the distal lung of E17.5-18.5 mutants is still populated by epithelial tubules, lacking the typical saccular structural characteristic of a normal E17.5 lung. |
| T8 |
980-1205 |
Sentence |
denotes |
Immunostaining revealed strong signals of surfactant protein-C, but a weaker signal of T1α in the mutant lungs in comparison to WT littermates, suggesting differentiation of type I alveolar epithelial cells (AT1) is impaired. |
| T9 |
1206-1324 |
Sentence |
denotes |
One of the parameters contributed to the failure of AT1 maturation is reduced vascularization in the developing lungs. |
