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PubMed:26260790 JSONTXT 22 Projects

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Id Subject Object Predicate Lexical cue
T1 0-115 Sentence denotes Adipose Tissue Lipolysis Promotes Exercise-induced Cardiac Hypertrophy Involving the Lipokine C16:1n7-Palmitoleate.
T2 116-238 Sentence denotes Endurance exercise training induces substantial adaptive cardiac modifications such as left ventricular hypertrophy (LVH).
T3 239-389 Sentence denotes Simultaneously to the development of LVH, adipose tissue (AT) lipolysis becomes elevated upon endurance training to cope with enhanced energy demands.
T4 390-519 Sentence denotes In this study, we investigated the impact of adipose tissue lipolysis on the development of exercise-induced cardiac hypertrophy.
T5 520-639 Sentence denotes Mice deficient for adipose triglyceride lipase (Atgl) in AT (atATGL-KO) were challenged with chronic treadmill running.
T6 640-787 Sentence denotes Exercise-induced AT lipolytic activity was significantly reduced in atATGL-KO mice accompanied by the absence of a plasma fatty acid (FA) increase.
T7 788-972 Sentence denotes These processes were directly associated with a prominent attenuation of myocardial FA uptake in atATGL-KO and a significant reduction of the cardiac hypertrophic response to exercise.
T8 973-1149 Sentence denotes FA serum profiling revealed palmitoleic acid (C16:1n7) as a new molecular co-mediator of exercise-induced cardiac hypertrophy by inducing nonproliferative cardiomyocyte growth.
T9 1150-1242 Sentence denotes In parallel, serum FA analysis and echocardiography were performed in 25 endurance athletes.
T10 1243-1409 Sentence denotes In consonance, the serum C16:1n7 palmitoleate level exhibited a significantly positive correlation with diastolic interventricular septum thickness in those athletes.
T11 1410-1512 Sentence denotes No correlation existed between linoleic acid (18:2n6) and diastolic interventricular septum thickness.
T12 1513-1738 Sentence denotes Collectively, our data provide the first evidence that adipose tissue lipolysis directly promotes the development of exercise-induced cardiac hypertrophy involving the lipokine C16:1n7 palmitoleate as a molecular co-mediator.
T13 1739-1900 Sentence denotes The identification of a lipokine involved in physiological cardiac growth may help to develop future lipid-based therapies for pathological LVH or heart failure.