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Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-76 Sentence denotes miR-19a acts as an oncogenic microRNA and is up-regulated in bladder cancer.
T1 0-76 Sentence denotes miR-19a acts as an oncogenic microRNA and is up-regulated in bladder cancer.
TextSentencer_T2 77-88 Sentence denotes BACKGROUND:
T2 77-88 Sentence denotes BACKGROUND:
TextSentencer_T3 89-225 Sentence denotes The application of microRNAs (miRNAs) as potential biomarkers and therapy targets has been widely investigated in many kinds of cancers.
T3 89-225 Sentence denotes The application of microRNAs (miRNAs) as potential biomarkers and therapy targets has been widely investigated in many kinds of cancers.
TextSentencer_T4 226-370 Sentence denotes The discovery of tumor associated miRNAs in serum of patients supported the use of plasma/serum miRNAs as noninvasive means of cancer detection.
T4 226-370 Sentence denotes The discovery of tumor associated miRNAs in serum of patients supported the use of plasma/serum miRNAs as noninvasive means of cancer detection.
TextSentencer_T5 371-522 Sentence denotes However, the aberrant expression of miRNAs in bladder cancer patients and their intensive roles and mechanisms in bladder cancer are poorly understood.
T5 371-522 Sentence denotes However, the aberrant expression of miRNAs in bladder cancer patients and their intensive roles and mechanisms in bladder cancer are poorly understood.
TextSentencer_T6 523-531 Sentence denotes METHODS:
T6 523-531 Sentence denotes METHODS:
TextSentencer_T7 532-993 Sentence denotes Taqman probe stem-loop real-time PCR was used to accurately measure the levels of miR-19a in bladder cancer cell lines, 100 pairs of bladder cancer tissues and the adjacent non-neoplastic tissues and also the plasma collected from bladder cancer patients and normal controls. miR-19a mimics and inhibitors were transfected into bladder cancer cells to investigate its role on regulating cell proliferation which was measured by CCK-8 and colony formation assay.
T7 532-993 Sentence denotes Taqman probe stem-loop real-time PCR was used to accurately measure the levels of miR-19a in bladder cancer cell lines, 100 pairs of bladder cancer tissues and the adjacent non-neoplastic tissues and also the plasma collected from bladder cancer patients and normal controls. miR-19a mimics and inhibitors were transfected into bladder cancer cells to investigate its role on regulating cell proliferation which was measured by CCK-8 and colony formation assay.
TextSentencer_T8 994-1184 Sentence denotes The target of miR-19a was identified by western blot and whether its regulatory role depends on its target was improved by a rescue experiment with miR-19a mimic and PTEN expression plasmid.
T8 994-1184 Sentence denotes The target of miR-19a was identified by western blot and whether its regulatory role depends on its target was improved by a rescue experiment with miR-19a mimic and PTEN expression plasmid.
TextSentencer_T9 1185-1351 Sentence denotes RESULTS: miR-19a was significantly up-regulated in bladder cancer tissues and high-level of miR-19a was correlative with more aggressive phenotypes of bladder cancer.
T9 1185-1351 Sentence denotes RESULTS: miR-19a was significantly up-regulated in bladder cancer tissues and high-level of miR-19a was correlative with more aggressive phenotypes of bladder cancer.
TextSentencer_T10 1352-1573 Sentence denotes Meanwhile, gain or loss of function of miR-19a demonstrated that miR-19a can promote cell growth of bladder cancer cells and the further mechanism studies indicated that its oncogenic role was dependent on targeting PTEN.
T10 1352-1573 Sentence denotes Meanwhile, gain or loss of function of miR-19a demonstrated that miR-19a can promote cell growth of bladder cancer cells and the further mechanism studies indicated that its oncogenic role was dependent on targeting PTEN.
TextSentencer_T11 1574-1841 Sentence denotes Furthermore, investigation of miR-19a expression in the plasma of bladder cancer patients showed that miR-19a was also increased in plasma of bladder cancer patients which strongly supported miR-19a could be developed as potential diagnostic marker of bladder cancer.
T11 1574-1841 Sentence denotes Furthermore, investigation of miR-19a expression in the plasma of bladder cancer patients showed that miR-19a was also increased in plasma of bladder cancer patients which strongly supported miR-19a could be developed as potential diagnostic marker of bladder cancer.
TextSentencer_T12 1842-1854 Sentence denotes CONCLUSIONS:
T12 1842-1854 Sentence denotes CONCLUSIONS:
TextSentencer_T13 1855-2008 Sentence denotes Our data indicated that miR-19a might act as an oncogenic microRNA in bladder cancer and was significantly up-regulated in bladder cancer carcinogenesis.
T13 1855-2008 Sentence denotes Our data indicated that miR-19a might act as an oncogenic microRNA in bladder cancer and was significantly up-regulated in bladder cancer carcinogenesis.
TextSentencer_T14 2009-2088 Sentence denotes The oncogenic role of miR19a in bladder cancer was dependent on targeting PTEN.
T14 2009-2088 Sentence denotes The oncogenic role of miR19a in bladder cancer was dependent on targeting PTEN.