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PubMed:20153822 JSONTXT 20 Projects

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Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-116 Sentence denotes Functional analysis of H. sapiens DNA polymerase gamma spacer mutation W748S with and without common variant E1143G.
T1 0-116 Sentence denotes Functional analysis of H. sapiens DNA polymerase gamma spacer mutation W748S with and without common variant E1143G.
TextSentencer_T2 117-209 Sentence denotes Mitochondrial DNA polymerase, POLG, is the sole DNA polymerase found in animal mitochondria.
T2 117-209 Sentence denotes Mitochondrial DNA polymerase, POLG, is the sole DNA polymerase found in animal mitochondria.
TextSentencer_T3 210-379 Sentence denotes In humans, POLGalpha W748S in cis with an E1143G mutation has been linked to a new type of recessive ataxia, MIRAS, which is the most common inherited ataxia in Finland.
T3 210-379 Sentence denotes In humans, POLGalpha W748S in cis with an E1143G mutation has been linked to a new type of recessive ataxia, MIRAS, which is the most common inherited ataxia in Finland.
TextSentencer_T4 380-484 Sentence denotes We investigated the biochemical phenotypes of the W748S amino acid change, using recombinant human POLG.
T4 380-484 Sentence denotes We investigated the biochemical phenotypes of the W748S amino acid change, using recombinant human POLG.
TextSentencer_T5 485-645 Sentence denotes We measured processive and non-processive DNA polymerase activity, DNA binding affinity, enzyme processivity, and subunit interaction with recombinant POLGbeta.
T5 485-645 Sentence denotes We measured processive and non-processive DNA polymerase activity, DNA binding affinity, enzyme processivity, and subunit interaction with recombinant POLGbeta.
TextSentencer_T6 646-777 Sentence denotes In addition, we studied the effects of the W748S and E1143G mutations in primary human cell cultures using retroviral transduction.
T6 646-777 Sentence denotes In addition, we studied the effects of the W748S and E1143G mutations in primary human cell cultures using retroviral transduction.
TextSentencer_T7 778-885 Sentence denotes Here, we examined cell viability, mitochondrial DNA copy number, and products of mitochondrial translation.
T7 778-885 Sentence denotes Here, we examined cell viability, mitochondrial DNA copy number, and products of mitochondrial translation.
TextSentencer_T8 886-1100 Sentence denotes Our results indicate that the W748S mutant POLGalpha does not exhibit a clear biochemical phenotype, making it indistinguishable from wild type POLGalpha and as such, fail to replicate previously published results.
T8 886-1100 Sentence denotes Our results indicate that the W748S mutant POLGalpha does not exhibit a clear biochemical phenotype, making it indistinguishable from wild type POLGalpha and as such, fail to replicate previously published results.
TextSentencer_T9 1101-1229 Sentence denotes Furthermore, results from the cell models were concurrent with the findings from patients, and support our biochemical findings.
T9 1101-1229 Sentence denotes Furthermore, results from the cell models were concurrent with the findings from patients, and support our biochemical findings.