Id |
Subject |
Object |
Predicate |
Lexical cue |
TextSentencer_T1 |
0-116 |
Sentence |
denotes |
Functional analysis of H. sapiens DNA polymerase gamma spacer mutation W748S with and without common variant E1143G. |
T1 |
0-116 |
Sentence |
denotes |
Functional analysis of H. sapiens DNA polymerase gamma spacer mutation W748S with and without common variant E1143G. |
TextSentencer_T2 |
117-209 |
Sentence |
denotes |
Mitochondrial DNA polymerase, POLG, is the sole DNA polymerase found in animal mitochondria. |
T2 |
117-209 |
Sentence |
denotes |
Mitochondrial DNA polymerase, POLG, is the sole DNA polymerase found in animal mitochondria. |
TextSentencer_T3 |
210-379 |
Sentence |
denotes |
In humans, POLGalpha W748S in cis with an E1143G mutation has been linked to a new type of recessive ataxia, MIRAS, which is the most common inherited ataxia in Finland. |
T3 |
210-379 |
Sentence |
denotes |
In humans, POLGalpha W748S in cis with an E1143G mutation has been linked to a new type of recessive ataxia, MIRAS, which is the most common inherited ataxia in Finland. |
TextSentencer_T4 |
380-484 |
Sentence |
denotes |
We investigated the biochemical phenotypes of the W748S amino acid change, using recombinant human POLG. |
T4 |
380-484 |
Sentence |
denotes |
We investigated the biochemical phenotypes of the W748S amino acid change, using recombinant human POLG. |
TextSentencer_T5 |
485-645 |
Sentence |
denotes |
We measured processive and non-processive DNA polymerase activity, DNA binding affinity, enzyme processivity, and subunit interaction with recombinant POLGbeta. |
T5 |
485-645 |
Sentence |
denotes |
We measured processive and non-processive DNA polymerase activity, DNA binding affinity, enzyme processivity, and subunit interaction with recombinant POLGbeta. |
TextSentencer_T6 |
646-777 |
Sentence |
denotes |
In addition, we studied the effects of the W748S and E1143G mutations in primary human cell cultures using retroviral transduction. |
T6 |
646-777 |
Sentence |
denotes |
In addition, we studied the effects of the W748S and E1143G mutations in primary human cell cultures using retroviral transduction. |
TextSentencer_T7 |
778-885 |
Sentence |
denotes |
Here, we examined cell viability, mitochondrial DNA copy number, and products of mitochondrial translation. |
T7 |
778-885 |
Sentence |
denotes |
Here, we examined cell viability, mitochondrial DNA copy number, and products of mitochondrial translation. |
TextSentencer_T8 |
886-1100 |
Sentence |
denotes |
Our results indicate that the W748S mutant POLGalpha does not exhibit a clear biochemical phenotype, making it indistinguishable from wild type POLGalpha and as such, fail to replicate previously published results. |
T8 |
886-1100 |
Sentence |
denotes |
Our results indicate that the W748S mutant POLGalpha does not exhibit a clear biochemical phenotype, making it indistinguishable from wild type POLGalpha and as such, fail to replicate previously published results. |
TextSentencer_T9 |
1101-1229 |
Sentence |
denotes |
Furthermore, results from the cell models were concurrent with the findings from patients, and support our biochemical findings. |
T9 |
1101-1229 |
Sentence |
denotes |
Furthermore, results from the cell models were concurrent with the findings from patients, and support our biochemical findings. |