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Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-137 Sentence denotes Proteomic and functional analyses reveal a dual molecular mechanism underlying arsenic-induced apoptosis in human multiple myeloma cells.
T1 0-137 Sentence denotes Proteomic and functional analyses reveal a dual molecular mechanism underlying arsenic-induced apoptosis in human multiple myeloma cells.
TextSentencer_T2 138-281 Sentence denotes Multiple myeloma (MM) is an incurable plasma cell malignancy with a terminal phase marked by increased proliferation and resistance to therapy.
T2 138-281 Sentence denotes Multiple myeloma (MM) is an incurable plasma cell malignancy with a terminal phase marked by increased proliferation and resistance to therapy.
TextSentencer_T3 282-439 Sentence denotes Arsenic trioxide (ATO), an antitumor agent with a multifaceted mechanism of action, displayed clinical activity in patients with late-stage multiple myeloma.
T3 282-439 Sentence denotes Arsenic trioxide (ATO), an antitumor agent with a multifaceted mechanism of action, displayed clinical activity in patients with late-stage multiple myeloma.
TextSentencer_T4 440-526 Sentence denotes However, the precise mechanism(s) of action of ATO has not been completely elucidated.
T4 440-526 Sentence denotes However, the precise mechanism(s) of action of ATO has not been completely elucidated.
TextSentencer_T5 527-727 Sentence denotes In the present study, we used proteomics to analyze the ATO-induced protein alterations in MM cell line U266 and then investigated the molecular pathways responsible for the anticancer actions of ATO.
T5 527-727 Sentence denotes In the present study, we used proteomics to analyze the ATO-induced protein alterations in MM cell line U266 and then investigated the molecular pathways responsible for the anticancer actions of ATO.
TextSentencer_T6 728-964 Sentence denotes Several clusters of proteins altered in expression in U266 cells upon ATO treatment were identified, including down-regulated signal transduction proteins and ubiquitin/proteasome members, and up-regulated immunity and defense proteins.
T6 728-964 Sentence denotes Several clusters of proteins altered in expression in U266 cells upon ATO treatment were identified, including down-regulated signal transduction proteins and ubiquitin/proteasome members, and up-regulated immunity and defense proteins.
TextSentencer_T7 965-1076 Sentence denotes Significantly regulated 14-3-3zeta and heat shock proteins (HSPs) were selected for further functional studies.
T7 965-1076 Sentence denotes Significantly regulated 14-3-3zeta and heat shock proteins (HSPs) were selected for further functional studies.
TextSentencer_T8 1077-1274 Sentence denotes Overexpression of 14-3-3zeta in MM cells attenuated ATO-induced cell death, whereas RNAi-based 14-3-3zeta knock-down or the inhibition of HSP90 enhanced tumor cell sensitivity to the ATO induction.
T8 1077-1274 Sentence denotes Overexpression of 14-3-3zeta in MM cells attenuated ATO-induced cell death, whereas RNAi-based 14-3-3zeta knock-down or the inhibition of HSP90 enhanced tumor cell sensitivity to the ATO induction.
TextSentencer_T9 1275-1480 Sentence denotes These observations implicate 14-3-3zeta and HSP90 as potential molecular targets for drug intervention of multiple myeloma and thus improve our understanding on the mechanisms of antitumor activity of ATO.
T9 1275-1480 Sentence denotes These observations implicate 14-3-3zeta and HSP90 as potential molecular targets for drug intervention of multiple myeloma and thus improve our understanding on the mechanisms of antitumor activity of ATO.