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Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-148 Sentence denotes POMT2, a key enzyme in Walker-Warburg syndrome: somatic sPOMT2, but not testis-specific tPOMT2, is crucial for mannosyltransferase activity in vivo.
T1 0-148 Sentence denotes POMT2, a key enzyme in Walker-Warburg syndrome: somatic sPOMT2, but not testis-specific tPOMT2, is crucial for mannosyltransferase activity in vivo.
T1 0-148 Sentence denotes POMT2, a key enzyme in Walker-Warburg syndrome: somatic sPOMT2, but not testis-specific tPOMT2, is crucial for mannosyltransferase activity in vivo.
TextSentencer_T2 149-236 Sentence denotes O-Mannosylation represents an evolutionarily conserved, essential protein modification.
T2 149-236 Sentence denotes O-Mannosylation represents an evolutionarily conserved, essential protein modification.
T2 149-236 Sentence denotes O-Mannosylation represents an evolutionarily conserved, essential protein modification.
TextSentencer_T3 237-385 Sentence denotes In mammals the protein O-mannosyltransferases POMT1 and POMT2 act as a heteromeric complex to initiate O-mannosylation in the endoplasmic reticulum.
T3 237-385 Sentence denotes In mammals the protein O-mannosyltransferases POMT1 and POMT2 act as a heteromeric complex to initiate O-mannosylation in the endoplasmic reticulum.
T3 237-385 Sentence denotes In mammals the protein O-mannosyltransferases POMT1 and POMT2 act as a heteromeric complex to initiate O-mannosylation in the endoplasmic reticulum.
TextSentencer_T4 386-523 Sentence denotes Mutations in human POMT1 and POMT2 cause a group of congenital muscular dystrophies due to reduced O-glycosylation of alpha-dystroglycan.
T4 386-523 Sentence denotes Mutations in human POMT1 and POMT2 cause a group of congenital muscular dystrophies due to reduced O-glycosylation of alpha-dystroglycan.
T4 386-523 Sentence denotes Mutations in human POMT1 and POMT2 cause a group of congenital muscular dystrophies due to reduced O-glycosylation of alpha-dystroglycan.
TextSentencer_T5 524-654 Sentence denotes The most severe of these autosomal recessive conditions is Walker-Warburg syndrome (WWS) with severe brain and ocular involvement.
T5 524-654 Sentence denotes The most severe of these autosomal recessive conditions is Walker-Warburg syndrome (WWS) with severe brain and ocular involvement.
T5 524-654 Sentence denotes The most severe of these autosomal recessive conditions is Walker-Warburg syndrome (WWS) with severe brain and ocular involvement.
TextSentencer_T6 655-783 Sentence denotes We previously showed in the murine model that Pomt1 is expressed in WWS-related tissues both during embryogenesis and in adults.
T6 655-783 Sentence denotes We previously showed in the murine model that Pomt1 is expressed in WWS-related tissues both during embryogenesis and in adults.
T6 655-783 Sentence denotes We previously showed in the murine model that Pomt1 is expressed in WWS-related tissues both during embryogenesis and in adults.
TextSentencer_T7 784-943 Sentence denotes Whereas there is only a single Pomt1 transcript in adult mice, we demonstrated that there are two Pomt2 transcripts, somatic sPomt2 and testis-specific tPomt2.
T7 784-943 Sentence denotes Whereas there is only a single Pomt1 transcript in adult mice, we demonstrated that there are two Pomt2 transcripts, somatic sPomt2 and testis-specific tPomt2.
T7 784-943 Sentence denotes Whereas there is only a single Pomt1 transcript in adult mice, we demonstrated that there are two Pomt2 transcripts, somatic sPomt2 and testis-specific tPomt2.
TextSentencer_T8 944-1134 Sentence denotes In this study we demonstrate that sPomt2, but not tPomt2, is prominently expressed in mouse embryos in the tissues that are most severely affected in WWS (developing muscle, eye, and brain).
T8 944-1134 Sentence denotes In this study we demonstrate that sPomt2, but not tPomt2, is prominently expressed in mouse embryos in the tissues that are most severely affected in WWS (developing muscle, eye, and brain).
T8 944-1134 Sentence denotes In this study we demonstrate that sPomt2, but not tPomt2, is prominently expressed in mouse embryos in the tissues that are most severely affected in WWS (developing muscle, eye, and brain).
TextSentencer_T9 1135-1337 Sentence denotes Correlation of POMT transcripts and protein isoforms with POMT mannosyltransferase enzyme activity demonstrates that sPOMT2-POMT1 complexes catalyze mannosyltransfer in adult somatic tissues and testis.
T9 1135-1337 Sentence denotes Correlation of POMT transcripts and protein isoforms with POMT mannosyltransferase enzyme activity demonstrates that sPOMT2-POMT1 complexes catalyze mannosyltransfer in adult somatic tissues and testis.
T9 1135-1337 Sentence denotes Correlation of POMT transcripts and protein isoforms with POMT mannosyltransferase enzyme activity demonstrates that sPOMT2-POMT1 complexes catalyze mannosyltransfer in adult somatic tissues and testis.
TextSentencer_T10 1338-1454 Sentence denotes It is suggested that the gonadal defects described in some WWS cases are associated with defects in O-mannosylation.
T10 1338-1454 Sentence denotes It is suggested that the gonadal defects described in some WWS cases are associated with defects in O-mannosylation.
T10 1338-1454 Sentence denotes It is suggested that the gonadal defects described in some WWS cases are associated with defects in O-mannosylation.
TextSentencer_T11 1455-1644 Sentence denotes Our data further show that whereas sPOMT2 is widely expressed, tPOMT2 is restricted to the acrosome of male germ cells and is not involved in the biosynthesis of O-mannosyl glycans in vivo.
T11 1455-1644 Sentence denotes Our data further show that whereas sPOMT2 is widely expressed, tPOMT2 is restricted to the acrosome of male germ cells and is not involved in the biosynthesis of O-mannosyl glycans in vivo.
T11 1455-1644 Sentence denotes Our data further show that whereas sPOMT2 is widely expressed, tPOMT2 is restricted to the acrosome of male germ cells and is not involved in the biosynthesis of O-mannosyl glycans in vivo.
TextSentencer_T12 1645-1778 Sentence denotes We prove that tPOMT2 is highly conserved among mammals, including humans, suggesting a crucial function that is distinct from sPOMT2.
T12 1645-1778 Sentence denotes We prove that tPOMT2 is highly conserved among mammals, including humans, suggesting a crucial function that is distinct from sPOMT2.
T12 1645-1778 Sentence denotes We prove that tPOMT2 is highly conserved among mammals, including humans, suggesting a crucial function that is distinct from sPOMT2.