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PubMed:18413728 JSONTXT 7 Projects

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Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-90 Sentence denotes Cyclin D1 and CDK4 activity contribute to the undifferentiated phenotype in neuroblastoma.
T1 0-90 Sentence denotes Cyclin D1 and CDK4 activity contribute to the undifferentiated phenotype in neuroblastoma.
TextSentencer_T2 91-284 Sentence denotes Genomic aberrations of Cyclin D1 (CCND1), CDK4, and CDK6 in neuroblastoma indicate that dysregulation of the G(1) entry checkpoint is an important cell cycle aberration in this pediatric tumor.
T2 91-284 Sentence denotes Genomic aberrations of Cyclin D1 (CCND1), CDK4, and CDK6 in neuroblastoma indicate that dysregulation of the G(1) entry checkpoint is an important cell cycle aberration in this pediatric tumor.
TextSentencer_T3 285-467 Sentence denotes Here, we report that analysis of Affymetrix expression data of primary neuroblastic tumors shows an extensive overexpression of Cyclin D1, which correlates with histologic subgroups.
T3 285-467 Sentence denotes Here, we report that analysis of Affymetrix expression data of primary neuroblastic tumors shows an extensive overexpression of Cyclin D1, which correlates with histologic subgroups.
TextSentencer_T4 468-612 Sentence denotes Immunohistochemical analysis showed overexpression of Cyclin D1 in neuroblasts and low Cyclin D1 expression in all cell types in ganglioneuroma.
T4 468-612 Sentence denotes Immunohistochemical analysis showed overexpression of Cyclin D1 in neuroblasts and low Cyclin D1 expression in all cell types in ganglioneuroma.
TextSentencer_T5 613-847 Sentence denotes This suggests an involvement of G(1)-regulating genes in neuronal differentiation processes which we further evaluated using RNA interference against Cyclin D1 and its kinase partners CDK4 and CDK6 in several neuroblastoma cell lines.
T5 613-847 Sentence denotes This suggests an involvement of G(1)-regulating genes in neuronal differentiation processes which we further evaluated using RNA interference against Cyclin D1 and its kinase partners CDK4 and CDK6 in several neuroblastoma cell lines.
TextSentencer_T6 848-1089 Sentence denotes The Cyclin D1 and CDK4 knockdown resulted in pRb pathway inhibition as shown by an almost complete disappearance of CDK4/CDK6-specific pRb phosphorylation, reduction of E2F transcriptional activity, and a decrease of Cyclin A protein levels.
T6 848-1089 Sentence denotes The Cyclin D1 and CDK4 knockdown resulted in pRb pathway inhibition as shown by an almost complete disappearance of CDK4/CDK6-specific pRb phosphorylation, reduction of E2F transcriptional activity, and a decrease of Cyclin A protein levels.
TextSentencer_T7 1090-1251 Sentence denotes Phenotype analysis showed a significant reduction in cell proliferation, a G(1)-specific cell cycle arrest, and, moreover, an extensive neuronal differentiation.
T7 1090-1251 Sentence denotes Phenotype analysis showed a significant reduction in cell proliferation, a G(1)-specific cell cycle arrest, and, moreover, an extensive neuronal differentiation.
TextSentencer_T8 1252-1390 Sentence denotes Affymetrix microarray profiling of small interfering RNA-treated cells revealed a shift in expression profile toward a neuronal phenotype.
T8 1252-1390 Sentence denotes Affymetrix microarray profiling of small interfering RNA-treated cells revealed a shift in expression profile toward a neuronal phenotype.
TextSentencer_T9 1391-1447 Sentence denotes Several new potential downstream players are identified.
T9 1391-1447 Sentence denotes Several new potential downstream players are identified.
TextSentencer_T10 1448-1587 Sentence denotes We conclude that neuroblastoma functionally depend on overexpression of G(1)-regulating genes to maintain their undifferentiated phenotype.
T10 1448-1587 Sentence denotes We conclude that neuroblastoma functionally depend on overexpression of G(1)-regulating genes to maintain their undifferentiated phenotype.