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Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-107 Sentence denotes Characterization of the LARGE family of putative glycosyltransferases associated with dystroglycanopathies.
T1 0-107 Sentence denotes Characterization of the LARGE family of putative glycosyltransferases associated with dystroglycanopathies.
T1 0-107 Sentence denotes Characterization of the LARGE family of putative glycosyltransferases associated with dystroglycanopathies.
TextSentencer_T2 108-208 Sentence denotes The Large(myd) mouse has a loss-of-function mutation in the putative glycosyltransferase gene Large.
T2 108-208 Sentence denotes The Large(myd) mouse has a loss-of-function mutation in the putative glycosyltransferase gene Large.
T2 108-319 Sentence denotes The Large(myd) mouse has a loss-of-function mutation in the putative glycosyltransferase gene Large. Mutations in the human homolog (LARGE) have been described in a form of congenital muscular dystrophy (MDC1D).
TextSentencer_T3 209-319 Sentence denotes Mutations in the human homolog (LARGE) have been described in a form of congenital muscular dystrophy (MDC1D).
T3 209-319 Sentence denotes Mutations in the human homolog (LARGE) have been described in a form of congenital muscular dystrophy (MDC1D).
TextSentencer_T4 320-492 Sentence denotes Other genes (POMT1, POMGnT1, fukutin, and FKRP) that encode known or putative glycosylation enzymes are also causally associated with human congenital muscular dystrophies.
T3 320-492 Sentence denotes Other genes (POMT1, POMGnT1, fukutin, and FKRP) that encode known or putative glycosylation enzymes are also causally associated with human congenital muscular dystrophies.
T4 320-492 Sentence denotes Other genes (POMT1, POMGnT1, fukutin, and FKRP) that encode known or putative glycosylation enzymes are also causally associated with human congenital muscular dystrophies.
TextSentencer_T5 493-656 Sentence denotes All these diseases are associated with hypoglycosylation of the membrane protein alpha-dystroglycan (alpha-DG) and consequent loss of extracellular ligand binding.
T4 493-656 Sentence denotes All these diseases are associated with hypoglycosylation of the membrane protein alpha-dystroglycan (alpha-DG) and consequent loss of extracellular ligand binding.
T5 493-656 Sentence denotes All these diseases are associated with hypoglycosylation of the membrane protein alpha-dystroglycan (alpha-DG) and consequent loss of extracellular ligand binding.
TextSentencer_T6 657-701 Sentence denotes Hence, they are termed dystroglycanopathies.
T5 657-701 Sentence denotes Hence, they are termed dystroglycanopathies.
T6 657-701 Sentence denotes Hence, they are termed dystroglycanopathies.
TextSentencer_T7 702-791 Sentence denotes A paralogous gene for LARGE (LARGE2 or GYLTL1B) may also have a role in DG glycosylation.
T6 702-791 Sentence denotes A paralogous gene for LARGE (LARGE2 or GYLTL1B) may also have a role in DG glycosylation.
T7 702-791 Sentence denotes A paralogous gene for LARGE (LARGE2 or GYLTL1B) may also have a role in DG glycosylation.
TextSentencer_T8 792-1032 Sentence denotes Using database interrogation and reverse-transcriptase polymerase chain reaction (RT-PCR), we identified vertebrate orthologs of each of these LARGE genes in many vertebrates, including human, mouse, dog, chicken, zebrafish, and pufferfish.
T7 792-1032 Sentence denotes Using database interrogation and reverse-transcriptase polymerase chain reaction (RT-PCR), we identified vertebrate orthologs of each of these LARGE genes in many vertebrates, including human, mouse, dog, chicken, zebrafish, and pufferfish.
T8 792-1032 Sentence denotes Using database interrogation and reverse-transcriptase polymerase chain reaction (RT-PCR), we identified vertebrate orthologs of each of these LARGE genes in many vertebrates, including human, mouse, dog, chicken, zebrafish, and pufferfish.
TextSentencer_T9 1033-1117 Sentence denotes However, within invertebrate genomes, we were able to identify only single homologs.
T8 1033-1117 Sentence denotes However, within invertebrate genomes, we were able to identify only single homologs.
T9 1033-1117 Sentence denotes However, within invertebrate genomes, we were able to identify only single homologs.
TextSentencer_T10 1118-1186 Sentence denotes We suggest that vertebrate LARGE orthologs be referred to as LARGE1.
T9 1118-1186 Sentence denotes We suggest that vertebrate LARGE orthologs be referred to as LARGE1.
T10 1118-1186 Sentence denotes We suggest that vertebrate LARGE orthologs be referred to as LARGE1.
TextSentencer_T11 1187-1309 Sentence denotes RT-PCR, dot-blot, and northern analysis indicated that LARGE2 has a more restricted tissue-expression profile than LARGE1.
T10 1187-1309 Sentence denotes RT-PCR, dot-blot, and northern analysis indicated that LARGE2 has a more restricted tissue-expression profile than LARGE1.
T11 1187-1309 Sentence denotes RT-PCR, dot-blot, and northern analysis indicated that LARGE2 has a more restricted tissue-expression profile than LARGE1.
TextSentencer_T12 1310-1409 Sentence denotes Using epitope-tagged proteins, we show that both LARGE1 and LARGE2 localize to the Golgi apparatus.
T11 1310-1409 Sentence denotes Using epitope-tagged proteins, we show that both LARGE1 and LARGE2 localize to the Golgi apparatus.
T12 1310-1409 Sentence denotes Using epitope-tagged proteins, we show that both LARGE1 and LARGE2 localize to the Golgi apparatus.
TextSentencer_T13 1410-1497 Sentence denotes The high similarity between the LARGE paralogs suggests that LARGE2 may also act on DG.
T12 1410-1497 Sentence denotes The high similarity between the LARGE paralogs suggests that LARGE2 may also act on DG.
T13 1410-1497 Sentence denotes The high similarity between the LARGE paralogs suggests that LARGE2 may also act on DG.
TextSentencer_T14 1498-1641 Sentence denotes Overexpression of LARGE2 in mouse C2C12 myoblasts results in increased glycosylation of alpha-DG accompanied by an increase in laminin binding.
T13 1498-1641 Sentence denotes Overexpression of LARGE2 in mouse C2C12 myoblasts results in increased glycosylation of alpha-DG accompanied by an increase in laminin binding.
T14 1498-1641 Sentence denotes Overexpression of LARGE2 in mouse C2C12 myoblasts results in increased glycosylation of alpha-DG accompanied by an increase in laminin binding.
TextSentencer_T15 1642-1709 Sentence denotes Thus, there may be functional redundancy between LARGE1 and LARGE2.
T14 1642-1709 Sentence denotes Thus, there may be functional redundancy between LARGE1 and LARGE2.
T15 1642-1709 Sentence denotes Thus, there may be functional redundancy between LARGE1 and LARGE2.
TextSentencer_T16 1710-1877 Sentence denotes Consistent with this idea, we show that alpha-DG is still fully glycosylated in kidney (a tissue that expresses a high level of LARGE2 mRNA) of Large(myd) mutant mice.
T15 1710-1877 Sentence denotes Consistent with this idea, we show that alpha-DG is still fully glycosylated in kidney (a tissue that expresses a high level of LARGE2 mRNA) of Large(myd) mutant mice.
T16 1710-1877 Sentence denotes Consistent with this idea, we show that alpha-DG is still fully glycosylated in kidney (a tissue that expresses a high level of LARGE2 mRNA) of Large(myd) mutant mice.