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Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-71 Sentence denotes Androgen receptor gene mutations in hormone-refractory prostate cancer.
T1 0-71 Sentence denotes Androgen receptor gene mutations in hormone-refractory prostate cancer.
TextSentencer_T2 72-161 Sentence denotes Prostate cancer is considered to be one of the most hormone-dependent human malignancies.
T2 72-161 Sentence denotes Prostate cancer is considered to be one of the most hormone-dependent human malignancies.
TextSentencer_T3 162-305 Sentence denotes As a key mediator of hormonal response, the androgen receptor (AR) is believed to have an important role in the progression of prostate cancer.
T3 162-305 Sentence denotes As a key mediator of hormonal response, the androgen receptor (AR) is believed to have an important role in the progression of prostate cancer.
TextSentencer_T4 306-569 Sentence denotes Mutations in the coding region of the AR gene have been found in both untreated and hormone-refractory prostate cancer, but the frequency of such mutations at different stages of the disease is poorly documented and even contradictory results have been published.
T4 306-569 Sentence denotes Mutations in the coding region of the AR gene have been found in both untreated and hormone-refractory prostate cancer, but the frequency of such mutations at different stages of the disease is poorly documented and even contradictory results have been published.
TextSentencer_T5 570-843 Sentence denotes In the present study, the frequency of AR gene mutations was determined in 30 locally recurrent and two metastatic hormone-refractory prostate tumours using the polymerase chain reaction (PCR), non-radioactive single strand conformation polymorphism (SSCP), and sequencing.
T5 570-843 Sentence denotes In the present study, the frequency of AR gene mutations was determined in 30 locally recurrent and two metastatic hormone-refractory prostate tumours using the polymerase chain reaction (PCR), non-radioactive single strand conformation polymorphism (SSCP), and sequencing.
TextSentencer_T6 844-1014 Sentence denotes The length of the polymorphic CAG repeat, which is inversely correlated with the ability of the AR to activate transcription, was also analysed as well as the GGC repeat.
T6 844-1014 Sentence denotes The length of the polymorphic CAG repeat, which is inversely correlated with the ability of the AR to activate transcription, was also analysed as well as the GGC repeat.
TextSentencer_T7 1015-1077 Sentence denotes Twelve samples were known to contain an AR gene amplification.
T7 1015-1077 Sentence denotes Twelve samples were known to contain an AR gene amplification.
TextSentencer_T8 1078-1243 Sentence denotes Altogether, one point mutation (Gly(674)-->Ala) and one microsatellite mutation (CAG(20)-->CAG(18)) were found, both in cancers containing the AR gene amplification.
T8 1078-1243 Sentence denotes Altogether, one point mutation (Gly(674)-->Ala) and one microsatellite mutation (CAG(20)-->CAG(18)) were found, both in cancers containing the AR gene amplification.
TextSentencer_T9 1244-1356 Sentence denotes The mean lengths of the polymorphic CAG and GGC repeats were similar to those observed in the normal population.
T9 1244-1356 Sentence denotes The mean lengths of the polymorphic CAG and GGC repeats were similar to those observed in the normal population.
TextSentencer_T10 1357-1526 Sentence denotes These results favour the view that mutations in the AR gene are rare in hormone-refractory prostate cancer and do not play an important role, at least, in local relapse.
T10 1357-1526 Sentence denotes These results favour the view that mutations in the AR gene are rare in hormone-refractory prostate cancer and do not play an important role, at least, in local relapse.
TextSentencer_T11 1527-1702 Sentence denotes Instead, the amplification and consequent overexpression of the wild-type AR gene seem to be the most common alteration involving the AR in hormone-refractory prostate cancer.
T11 1527-1702 Sentence denotes Instead, the amplification and consequent overexpression of the wild-type AR gene seem to be the most common alteration involving the AR in hormone-refractory prostate cancer.