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Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-124 Sentence denotes Distinct phenotypes associated with increasing dosage of the PLP gene: implications for CMT1A due to PMP22 gene duplication.
T1 0-124 Sentence denotes Distinct phenotypes associated with increasing dosage of the PLP gene: implications for CMT1A due to PMP22 gene duplication.
TextSentencer_T2 125-372 Sentence denotes Increased dosage of the proteolipid protein (Plp) gene causes CNS disease (Pelizaeus-Merzbacher disease [PMD]), which has many similarities to disorders of the PNS associated with duplication of the peripheral myelin protein-22 (PMP22) gene locus.
T2 125-372 Sentence denotes Increased dosage of the proteolipid protein (Plp) gene causes CNS disease (Pelizaeus-Merzbacher disease [PMD]), which has many similarities to disorders of the PNS associated with duplication of the peripheral myelin protein-22 (PMP22) gene locus.
TextSentencer_T3 373-466 Sentence denotes Transgenic mice carrying extra copies of the wild-type Plp gene provide a valid model of PMD.
T3 373-466 Sentence denotes Transgenic mice carrying extra copies of the wild-type Plp gene provide a valid model of PMD.
TextSentencer_T4 467-598 Sentence denotes Variations in gene dosage can cause a wide range of phenotypes from severe, lethal dysmyelination through late-onset demyelination.
T4 467-598 Sentence denotes Variations in gene dosage can cause a wide range of phenotypes from severe, lethal dysmyelination through late-onset demyelination.
TextSentencer_T5 599-804 Sentence denotes A predilection for different fiber diameters may occur within the various phenotypes with dysmyelination being more obvious in large fibers and late-onset degeneration predominantly affecting small fibers.
T5 599-804 Sentence denotes A predilection for different fiber diameters may occur within the various phenotypes with dysmyelination being more obvious in large fibers and late-onset degeneration predominantly affecting small fibers.
TextSentencer_T6 805-949 Sentence denotes Although the frequency of apoptotic oligodendrocytes is increased with high gene dosage, the number of mature oligodendrocytes appears adequate.
T6 805-949 Sentence denotes Although the frequency of apoptotic oligodendrocytes is increased with high gene dosage, the number of mature oligodendrocytes appears adequate.
TextSentencer_T7 950-1087 Sentence denotes Oligodendrocytes in the dysmyelinated CNS express a range of genes typical of mature cells, yet are unable to assemble sufficient myelin.
T7 950-1087 Sentence denotes Oligodendrocytes in the dysmyelinated CNS express a range of genes typical of mature cells, yet are unable to assemble sufficient myelin.
TextSentencer_T8 1088-1190 Sentence denotes Oligodendrocytes contain abnormal vacuoles and stain intensely for PLP and other proteins such as MAG.
T8 1088-1190 Sentence denotes Oligodendrocytes contain abnormal vacuoles and stain intensely for PLP and other proteins such as MAG.
TextSentencer_T9 1191-1335 Sentence denotes The findings suggest that with high gene dosage much of the PLP, and possibly other proteins, is missorted and degraded in the lysosomal system.
T9 1191-1335 Sentence denotes The findings suggest that with high gene dosage much of the PLP, and possibly other proteins, is missorted and degraded in the lysosomal system.