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PMC:3586680 / 7511-9219 JSONTXT 25 Projects

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Id Subject Object Predicate Lexical cue
T12775 0-63 Sentence denotes Schematic diagrams of WWOX structure and its role in signaling.
T12776 64-192 Sentence denotes WWOX contains two N-terminal WW domains, a C-terminal short-chain alcohol dehydrogenase/reductase (SDR) domain, and a D3 region.
T53 64-192 Sentence denotes WWOX contains two N-terminal WW domains, a C-terminal short-chain alcohol dehydrogenase/reductase (SDR) domain, and a D3 region.
T12777 193-354 Sentence denotes A nuclear localization signal (NLS) is in between the WW domains (Chang et al., 2003, 2007; Del Mare et al., 2011; Salah et al., 2012; Su et al., 2012; reviews).
T54 193-354 Sentence denotes A nuclear localization signal (NLS) is in between the WW domains (Chang et al., 2003, 2007; Del Mare et al., 2011; Salah et al., 2012; Su et al., 2012; reviews).
T12778 355-410 Sentence denotes The SDR domain possesses a mitochondria-binding region.
T55 355-410 Sentence denotes The SDR domain possesses a mitochondria-binding region.
T12779 411-484 Sentence denotes There are two conserved tyrosine phosphorylation sites, Tyr33 and Tyr287.
T56 411-484 Sentence denotes There are two conserved tyrosine phosphorylation sites, Tyr33 and Tyr287.
T12780 485-609 Sentence denotes Other phosphorylation sites predicted by NetPhos 2.0 Server are Tyr6, Thr12, Ser14, Tyr61, Tyr293, and Thr3B3, respectively.
T57 485-609 Sentence denotes Other phosphorylation sites predicted by NetPhos 2.0 Server are Tyr6, Thr12, Ser14, Tyr61, Tyr293, and Thr3B3, respectively.
T12781 610-681 Sentence denotes Upon stress stimulation, WWOX is phosphorylated in Tyr33 and binds p53.
T58 610-681 Sentence denotes Upon stress stimulation, WWOX is phosphorylated in Tyr33 and binds p53.
T12782 682-768 Sentence denotes The WWOX/p53 complex then translocates to mitochondria or nucleus to induce apoptosis.
T59 682-768 Sentence denotes The WWOX/p53 complex then translocates to mitochondria or nucleus to induce apoptosis.
T12783 769-977 Sentence denotes WWOX also binds PPxY motif-containing transcription factors, such as RUNX2, c-Jun, and ERBB4, via its first WW domain, and the binding blocks the activity of these proteins by retaining them in the cytoplasm.
T60 769-977 Sentence denotes WWOX also binds PPxY motif-containing transcription factors, such as RUNX2, c-Jun, and ERBB4, via its first WW domain, and the binding blocks the activity of these proteins by retaining them in the cytoplasm.
T12784 978-1012 Sentence denotes WWOX binds Tau via its SDR domain.
T61 978-1012 Sentence denotes WWOX binds Tau via its SDR domain.
T12785 1013-1116 Sentence denotes WWOX participates in the Wnt/β-catenin signal pathway by binding Dvl and inhibiting its nuclear import.
T62 1013-1116 Sentence denotes WWOX participates in the Wnt/β-catenin signal pathway by binding Dvl and inhibiting its nuclear import.
T12786 1117-1275 Sentence denotes Phorbol ester stimulates the dissociation of MEK/WWOX complex in Jurkat T cell, and the released WWOX translocates to the mitochondria for causing cell death.
T63 1117-1275 Sentence denotes Phorbol ester stimulates the dissociation of MEK/WWOX complex in Jurkat T cell, and the released WWOX translocates to the mitochondria for causing cell death.
T64 1276-1360 Sentence denotes WWOX is recruited to the membrane area by association with Hyal-2 and phospho-Ezrin.
T12787 1276-1406 Sentence denotes WWOX is recruited to the membrane area by association with Hyal-2 and phospho-Ezrin. Hyal-2 is an alternative receptor for TGF-β1.
T65 1361-1406 Sentence denotes Hyal-2 is an alternative receptor for TGF-β1.
T12788 1407-1555 Sentence denotes In response to TGF-β1, WWOX binds Hyal-2 and forms a complex, followed by relocating to the nucleus and enhancing the SMAD-driven promoter activity.
T66 1407-1555 Sentence denotes In response to TGF-β1, WWOX binds Hyal-2 and forms a complex, followed by relocating to the nucleus and enhancing the SMAD-driven promoter activity.
T12789 1556-1708 Sentence denotes Ack1, activated Cdc42-associated kinase 1; Hyal-2, hyaluronoglucosaminidase 2; CKI, casein kinase; GSK, glycogen synthase kinase; PKA, protein kinase A.
T67 1556-1708 Sentence denotes Ack1, activated Cdc42-associated kinase 1; Hyal-2, hyaluronoglucosaminidase 2; CKI, casein kinase; GSK, glycogen synthase kinase; PKA, protein kinase A.