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PMC:3586680 / 13710-14833 JSONTXT 23 Projects

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Id Subject Object Predicate Lexical cue
T94 0-289 Sentence denotes Figure 2 p53 and WWOX in GBM cell apoptosis. (A) Full-length p53 possesses two N-terminal transactivation acidic domains, a proline-rich domain, a central DNA-binding region, and a C-terminal domain, containing a nuclear localization signal, an oligomerization domain, and a basic region.
T14072 10-289 Sentence denotes p53 and WWOX in GBM cell apoptosis. (A) Full-length p53 possesses two N-terminal transactivation acidic domains, a proline-rich domain, a central DNA-binding region, and a C-terminal domain, containing a nuclear localization signal, an oligomerization domain, and a basic region.
T14073 290-425 Sentence denotes N-terminal deletion mutants of p53 are also shown. (B) Three likely scenarios are proposed for WWOX and p53 to regulate GBM cell death.
T95 290-425 Sentence denotes N-terminal deletion mutants of p53 are also shown. (B) Three likely scenarios are proposed for WWOX and p53 to regulate GBM cell death.
T14074 426-521 Sentence denotes First, ectopic WWOX fails to induce apoptosis of GBM cells expressing endogenous wild type p53.
T96 426-521 Sentence denotes First, ectopic WWOX fails to induce apoptosis of GBM cells expressing endogenous wild type p53.
T14075 522-661 Sentence denotes It appears that ectopic WWOX binds and functionally antagonizes p53, and both proteins nullify each other’s function in inducing apoptosis.
T97 522-661 Sentence denotes It appears that ectopic WWOX binds and functionally antagonizes p53, and both proteins nullify each other’s function in inducing apoptosis.
T14076 662-758 Sentence denotes Second, no physical interactions between mutant p53 proteins and WWOX are expected in GBM cells.
T98 662-758 Sentence denotes Second, no physical interactions between mutant p53 proteins and WWOX are expected in GBM cells.
T14077 759-826 Sentence denotes Thus, ectopic WWOX induce apoptosis in mutant p53-expressing cells.
T99 759-826 Sentence denotes Thus, ectopic WWOX induce apoptosis in mutant p53-expressing cells.
T14078 827-879 Sentence denotes Finally, whether WWOX binds p53 isoforms is unknown.
T100 827-879 Sentence denotes Finally, whether WWOX binds p53 isoforms is unknown.
T14079 880-993 Sentence denotes Also, whether ectopic WWOX induction of apoptosis in GBM cells expressing p53 isoforms remains to be established.
T101 880-993 Sentence denotes Also, whether ectopic WWOX induction of apoptosis in GBM cells expressing p53 isoforms remains to be established.
T14080 994-1123 Sentence denotes TAD, transactivation domain; PrD, proline domain; NLS, nuclear localization signal; OD, oligomerization domain; BR, basic region.
T102 994-1123 Sentence denotes TAD, transactivation domain; PrD, proline domain; NLS, nuclear localization signal; OD, oligomerization domain; BR, basic region.