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PMC:3586680 / 12856-14833 JSONTXT 24 Projects

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Id Subject Object Predicate Lexical cue
T90 0-17 Sentence denotes p53 and Functions
T6773 18-133 Sentence denotes Activated p53 mediates apoptosis, cell cycle arrest, senescence, DNA repair, or metabolism (Lane and Levine, 2010).
T91 18-133 Sentence denotes Activated p53 mediates apoptosis, cell cycle arrest, senescence, DNA repair, or metabolism (Lane and Levine, 2010).
T6774 134-663 Sentence denotes The primary structures of p53 and its isoforms are depicted (Figure 2). p53 induces cell cycle arrest by transactivating genes such as cyclin-dependent kinase inhibitor p21, or microRNA miR34. p53 induces apoptosis by transactivating proapoptotic genes such as BAX, PUMA, SCOTIN, and FAS, and inhibiting the antiapoptotic gene BCL-2 (Lane and Levine, 2010). p53 triggers pro-survival or cell death response, depending upon cell types, the intensity of the stress signal, and the extent of cellular damage (Menendez et al., 2009).
T92 134-663 Sentence denotes The primary structures of p53 and its isoforms are depicted (Figure 2). p53 induces cell cycle arrest by transactivating genes such as cyclin-dependent kinase inhibitor p21, or microRNA miR34. p53 induces apoptosis by transactivating proapoptotic genes such as BAX, PUMA, SCOTIN, and FAS, and inhibiting the antiapoptotic gene BCL-2 (Lane and Levine, 2010). p53 triggers pro-survival or cell death response, depending upon cell types, the intensity of the stress signal, and the extent of cellular damage (Menendez et al., 2009).
T6775 664-853 Sentence denotes Also, p53 plays a role in controlling cell motility via regulating the expression of smooth muscle α-actin (Comer et al., 1998), collagens IIα1 and VIα1 (Sun et al., 1999), and many others.
T93 664-853 Sentence denotes Also, p53 plays a role in controlling cell motility via regulating the expression of smooth muscle α-actin (Comer et al., 1998), collagens IIα1 and VIα1 (Sun et al., 1999), and many others.
T94 854-1143 Sentence denotes Figure 2 p53 and WWOX in GBM cell apoptosis. (A) Full-length p53 possesses two N-terminal transactivation acidic domains, a proline-rich domain, a central DNA-binding region, and a C-terminal domain, containing a nuclear localization signal, an oligomerization domain, and a basic region.
T14072 864-1143 Sentence denotes p53 and WWOX in GBM cell apoptosis. (A) Full-length p53 possesses two N-terminal transactivation acidic domains, a proline-rich domain, a central DNA-binding region, and a C-terminal domain, containing a nuclear localization signal, an oligomerization domain, and a basic region.
T14073 1144-1279 Sentence denotes N-terminal deletion mutants of p53 are also shown. (B) Three likely scenarios are proposed for WWOX and p53 to regulate GBM cell death.
T95 1144-1279 Sentence denotes N-terminal deletion mutants of p53 are also shown. (B) Three likely scenarios are proposed for WWOX and p53 to regulate GBM cell death.
T14074 1280-1375 Sentence denotes First, ectopic WWOX fails to induce apoptosis of GBM cells expressing endogenous wild type p53.
T96 1280-1375 Sentence denotes First, ectopic WWOX fails to induce apoptosis of GBM cells expressing endogenous wild type p53.
T14075 1376-1515 Sentence denotes It appears that ectopic WWOX binds and functionally antagonizes p53, and both proteins nullify each other’s function in inducing apoptosis.
T97 1376-1515 Sentence denotes It appears that ectopic WWOX binds and functionally antagonizes p53, and both proteins nullify each other’s function in inducing apoptosis.
T14076 1516-1612 Sentence denotes Second, no physical interactions between mutant p53 proteins and WWOX are expected in GBM cells.
T98 1516-1612 Sentence denotes Second, no physical interactions between mutant p53 proteins and WWOX are expected in GBM cells.
T14077 1613-1680 Sentence denotes Thus, ectopic WWOX induce apoptosis in mutant p53-expressing cells.
T99 1613-1680 Sentence denotes Thus, ectopic WWOX induce apoptosis in mutant p53-expressing cells.
T14078 1681-1733 Sentence denotes Finally, whether WWOX binds p53 isoforms is unknown.
T100 1681-1733 Sentence denotes Finally, whether WWOX binds p53 isoforms is unknown.
T14079 1734-1847 Sentence denotes Also, whether ectopic WWOX induction of apoptosis in GBM cells expressing p53 isoforms remains to be established.
T101 1734-1847 Sentence denotes Also, whether ectopic WWOX induction of apoptosis in GBM cells expressing p53 isoforms remains to be established.
T14080 1848-1977 Sentence denotes TAD, transactivation domain; PrD, proline domain; NLS, nuclear localization signal; OD, oligomerization domain; BR, basic region.
T102 1848-1977 Sentence denotes TAD, transactivation domain; PrD, proline domain; NLS, nuclear localization signal; OD, oligomerization domain; BR, basic region.