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PMC:3317373 / 15826-16891 JSONTXT 25 Projects

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Id Subject Object Predicate Lexical cue
T7216 0-104 Sentence denotes It has been demonstrated that NF-κB is activated in brain and spinal cord after traumatic injury [2, 9].
T162 0-104 Sentence denotes It has been demonstrated that NF-κB is activated in brain and spinal cord after traumatic injury [2, 9].
T7217 105-323 Sentence denotes As a transcript factor, NF-κB binds with DNA once it was activated and induces transcription of MMP9 and a battery of proinflammatory cytokines, including TNF-α, IL-1β, and IL-6, in brain tissues after TBI [3, 10, 11].
T163 105-323 Sentence denotes As a transcript factor, NF-κB binds with DNA once it was activated and induces transcription of MMP9 and a battery of proinflammatory cytokines, including TNF-α, IL-1β, and IL-6, in brain tissues after TBI [3, 10, 11].
T7218 324-512 Sentence denotes Our results also revealed that scratch injury induced elevation of NF-κB DNA binding activity, overexpression of MMP9, and proinflammatory mediators mentioned above in cultured astrocytes.
T164 324-512 Sentence denotes Our results also revealed that scratch injury induced elevation of NF-κB DNA binding activity, overexpression of MMP9, and proinflammatory mediators mentioned above in cultured astrocytes.
T7219 513-613 Sentence denotes It has been demonstrated that there is an autoregulatory loop among these proinflammatory mediators.
T165 513-613 Sentence denotes It has been demonstrated that there is an autoregulatory loop among these proinflammatory mediators.
T7220 614-841 Sentence denotes For example, TNF-α and IL-1β are potent stimulators for MMP9 in astrocytes [12, 13], and IL-6 induces overexpression of MMP9 in human colon carcinoma cells [14], and TNF-α and IL-1β also can induce activation of NF-κB [15, 16].
T166 614-841 Sentence denotes For example, TNF-α and IL-1β are potent stimulators for MMP9 in astrocytes [12, 13], and IL-6 induces overexpression of MMP9 in human colon carcinoma cells [14], and TNF-α and IL-1β also can induce activation of NF-κB [15, 16].
T7221 842-962 Sentence denotes This autoregulatory loop extremely aggravates the damaging effect of inflammation and induces secondary injury to brain.
T167 842-962 Sentence denotes This autoregulatory loop extremely aggravates the damaging effect of inflammation and induces secondary injury to brain.
T7222 963-1065 Sentence denotes It is a good choice for targeting on an upstream factor to prevent such autoregulatory loop after TBI.
T168 963-1065 Sentence denotes It is a good choice for targeting on an upstream factor to prevent such autoregulatory loop after TBI.