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PMC:3312845 / 29963-31395 JSONTXT 23 Projects

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Id Subject Object Predicate Lexical cue
T11636 0-144 Sentence denotes p65 phosphorylation of NF-κB enhances its transactivation potential, and p65 phosphorylation occurs in either the cytoplasm or the nucleus [30].
T221 0-144 Sentence denotes p65 phosphorylation of NF-κB enhances its transactivation potential, and p65 phosphorylation occurs in either the cytoplasm or the nucleus [30].
T11637 145-320 Sentence denotes In the present study, p65-Thr435 immunoreactivity was detected in endothelial cells, and its immunoreactivity showed an inverse correlation to the degree of SMI-71 expression.
T222 145-320 Sentence denotes In the present study, p65-Thr435 immunoreactivity was detected in endothelial cells, and its immunoreactivity showed an inverse correlation to the degree of SMI-71 expression.
T11638 321-421 Sentence denotes SMI-71, an endothelial barrier antigen, is a protein expressed by endothelial cells of rat BBB [31].
T223 321-421 Sentence denotes SMI-71, an endothelial barrier antigen, is a protein expressed by endothelial cells of rat BBB [31].
T11639 422-514 Sentence denotes Under pathological conditions, SMI-71 expression is lost in endothelial cells [5,7,8,30,32].
T224 422-514 Sentence denotes Under pathological conditions, SMI-71 expression is lost in endothelial cells [5,7,8,30,32].
T11640 515-643 Sentence denotes Acute phases of the above pathological conditions are accompanied by opening of the BBB and development of vasogenic edema [33].
T225 515-643 Sentence denotes Acute phases of the above pathological conditions are accompanied by opening of the BBB and development of vasogenic edema [33].
T11641 644-883 Sentence denotes Indeed, neutralization of SMI-71 in vivo leads to widening of intercellular junctions between endothelial cells and swelling of perivascular astrocytic processes [34], although SMI-71 is not localized at endothelial cell junctions [35-38].
T226 644-883 Sentence denotes Indeed, neutralization of SMI-71 in vivo leads to widening of intercellular junctions between endothelial cells and swelling of perivascular astrocytic processes [34], although SMI-71 is not localized at endothelial cell junctions [35-38].
T11642 884-1043 Sentence denotes In the present study, SMI-71 immunoreactivity was significantly reduced in blood vessels 1 day after SE when vasogenic edema and neuronal damage were observed.
T227 884-1043 Sentence denotes In the present study, SMI-71 immunoreactivity was significantly reduced in blood vessels 1 day after SE when vasogenic edema and neuronal damage were observed.
T11643 1044-1131 Sentence denotes Furthermore, sTNFp55R infusion effectively prevented SE-induced SMI-71 down-regulation.
T228 1044-1131 Sentence denotes Furthermore, sTNFp55R infusion effectively prevented SE-induced SMI-71 down-regulation.
T11644 1132-1432 Sentence denotes With respect to the phosphorylation of p65-Thr435 by TNF-α [39], our findings indicate that TNF-α-mediated p65-Thr435 phosphorylation in endothelial cells may play an important role in vasogenic edema induction via SMI-71 degradation or its posttranslational dysfunction influencing BBB permeability.
T229 1132-1432 Sentence denotes With respect to the phosphorylation of p65-Thr435 by TNF-α [39], our findings indicate that TNF-α-mediated p65-Thr435 phosphorylation in endothelial cells may play an important role in vasogenic edema induction via SMI-71 degradation or its posttranslational dysfunction influencing BBB permeability.