pubmed-sentences-benchmark  

PubMed:10358154 JSONTXT 12 Projects

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Id Subject Object Predicate Lexical cue
S1 0-108 Sentence denotes New immunosuppressive drug PNU156804 blocks IL-2-dependent proliferation and NF-kappa B and AP-1 activation.
S2 109-218 Sentence denotes We had previously shown that the drug undecylprodigiosin (UP) blocks human lymphocyte proliferation in vitro.
S3 219-366 Sentence denotes We have now investigated the mechanism of action of a new analogue of UP, PNU156804, which shows a more favorable activity profile than UP in mice.
S4 367-651 Sentence denotes We demonstrate here that the biological effect of PNU156804 in vitro is indistinguishable from UP: PNU156804 blocks human T cell proliferation in mid-late G1, as determined by cell cycle analysis, expression of cyclins, and cyclin-dependent kinases and retinoblastoma phosphorylation.
S5 652-828 Sentence denotes In addition, we show that PNU156804 does not block significantly the induction of either IL-2 or IL-2R alpha- and gamma-chains but inhibits IL-2-dependent T cell proliferation.
S6 829-927 Sentence denotes We have investigated several molecular pathways that are known to be activated by IL-2 in T cells.
S7 928-999 Sentence denotes We show that PNU156804 does not inhibit c-myc and bcl-2 mRNA induction.
S8 1000-1114 Sentence denotes On the other hand, PNU156804 efficiently inhibits the activation of the NF-kappa B and AP-1 transcription factors.
S9 1115-1243 Sentence denotes PNU156804 inhibition of NF-kappa B activation is due to the inhibition of the degradation of I kappa B-alpha and I kappa B-beta.
S10 1244-1425 Sentence denotes PNU156804 action is restricted to some signaling pathways; it does not affect NF-kappa B activation by PMA in T cells but blocks that induced by CD40 cross-linking in B lymphocytes.
S11 1426-1658 Sentence denotes We conclude that the prodigiosin family of immunosuppressants is a new family of molecules that show a novel target specificity clearly distinct from that of other immunosuppressive drugs such as cyclosporin A, FK506, and rapamycin.