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PMC:1310901 / 1798-28194 JSONTXT 20 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T1104 13-20 JJ denotes Chronic
T1105 21-28 JJ denotes myeloid
T1106 29-37 NN denotes leukemia
T1107 38-39 -LRB- denotes (
T1108 39-42 NN denotes CML
T1109 42-43 -RRB- denotes )
T1110 44-46 VB denotes is
T1111 47-48 DT denotes a
T1112 49-55 JJ denotes clonal
T1113 56-74 JJ denotes myeloproliferative
T1114 75-83 NN denotes disorder
T1115 84-88 IN denotes with
T1116 89-90 DT denotes a
T1117 91-98 JJ denotes typical
T1118 99-104 CD denotes three
T1119 105-111 JJ denotes phased
T1120 112-118 NN denotes course
T1121 119-120 -LRB- denotes (
T1122 120-127 JJ denotes chronic
T1123 127-128 -COMMA- denotes ,
T1124 129-140 JJ denotes accelerated
T1125 141-144 CC denotes and
T1126 145-152 JJ denotes blastic
T1127 153-158 NN denotes phase
T1128 158-159 -RRB- denotes )
T1129 160-170 VB denotes reflecting
T1130 171-174 DT denotes the
T1131 175-179 NN denotes loss
T1132 180-182 IN denotes of
T1133 183-198 NN denotes differentiation
T1134 199-202 CC denotes and
T1135 203-212 JJ denotes malignant
T1136 213-221 NN denotes progress
T1137 222-227 WDT denotes which
T1138 228-238 RB denotes inevitably
T1139 239-244 VB denotes leads
T1140 245-247 TO denotes to
T1141 248-253 NN denotes death
T1142 254-259 IN denotes after
T1143 260-263 DT denotes the
T1144 264-271 JJ denotes blastic
T1145 272-277 NN denotes phase
T1146 278-279 -LRB- denotes (
T1147 279-282 CD denotes 1,2
T1148 282-283 -RRB- denotes )
T1149 285-288 DT denotes The
T1150 289-297 NN denotes hallmark
T1151 298-305 JJ denotes genetic
T1152 306-316 NN denotes aberration
T1153 317-319 IN denotes of
T1154 320-323 NN denotes CML
T1155 324-326 VB denotes is
T1156 327-328 DT denotes a
T1157 329-339 JJ denotes reciprocal
T1158 340-351 JJ denotes chromosomal
T1159 352-365 NN denotes translocation
T1160 366-367 NN denotes t
T1161 367-368 -LRB- denotes (
T1162 368-369 CD denotes 9
T1163 369-370 -COLON- denotes ;
T1164 370-372 CD denotes 22
T1165 372-373 -RRB- denotes )
T1166 374-381 VB denotes leading
T1167 382-384 TO denotes to
T1168 385-395 NN denotes expression
T1169 396-398 IN denotes of
T1170 399-400 DT denotes a
T1171 401-408 NN denotes bcr-abl
T1172 409-415 NN denotes fusion
T1173 416-420 NN denotes gene
T1174 420-421 -COMMA- denotes ,
T1175 422-424 DT denotes an
T1176 425-433 JJ denotes aberrant
T1177 434-443 VB denotes activated
T1178 444-452 NN denotes tyrosine
T1179 453-459 NN denotes kinase
T1180 460-461 -LRB- denotes (
T1181 461-462 CD denotes 2
T1182 462-463 -RRB- denotes )
T1183 465-474 NN denotes Treatment
T1184 475-479 IN denotes with
T1185 480-490 NN denotes interferon
T1186 491-492 NN denotes α
T1187 493-494 -LRB- denotes (
T1188 494-499 NN denotes IFN-α
T1189 499-500 -RRB- denotes )
T1190 501-509 VB denotes prolongs
T1191 510-518 NN denotes survival
T1192 519-521 IN denotes of
T1193 522-525 NN denotes CML
T1194 526-534 NN denotes patients
T1195 535-538 CC denotes and
T1196 539-541 VB denotes is
T1197 542-552 VB denotes associated
T1198 553-557 IN denotes with
T1199 558-559 DT denotes a
T1200 560-568 JJ denotes complete
T1201 569-580 JJ denotes cytogenetic
T1202 581-589 NN denotes response
T1203 590-592 IN denotes in
T1204 593-597 CD denotes 5–33
T1205 597-598 NN denotes %
T1206 599-601 IN denotes of
T1207 602-605 NN denotes CML
T1208 606-614 NN denotes patients
T1209 615-616 -LRB- denotes (
T1210 616-619 CD denotes 1,2
T1211 619-620 -RRB- denotes )
T1212 622-630 RB denotes Recently
T1213 630-631 -COMMA- denotes ,
T1214 632-634 PRP denotes we
T1215 635-644 VB denotes described
T1216 645-647 DT denotes an
T1217 648-656 JJ denotes impaired
T1218 657-667 NN denotes expression
T1219 668-670 IN denotes of
T1220 671-674 DT denotes the
T1221 675-685 NN denotes interferon
T1222 686-696 JJ denotes regulatory
T1223 697-703 NN denotes factor
T1224 704-705 CD denotes 4
T1225 706-707 -LRB- denotes (
T1226 707-712 NN denotes IRF-4
T1227 712-713 -RRB- denotes )
T1228 714-716 IN denotes in
T1229 717-720 NN denotes CML
T1230 720-721 -COMMA- denotes ,
T1231 722-733 VB denotes correlating
T1232 734-738 IN denotes with
T1233 739-743 JJ denotes poor
T1234 744-752 NN denotes response
T1235 753-755 TO denotes to
T1236 756-761 NN denotes IFN-α
T1237 762-771 NN denotes treatment
T1238 772-773 -LRB- denotes (
T1239 773-774 CD denotes 3
T1240 774-775 -RRB- denotes )
T1241 777-780 DT denotes The
T1242 781-786 NN denotes cause
T1243 787-789 IN denotes of
T1244 790-793 DT denotes the
T1245 794-803 NN denotes silencing
T1246 804-806 IN denotes of
T1247 807-812 NN denotes IRF-4
T1248 813-818 NN denotes level
T1249 819-827 VB denotes remained
T1250 828-835 JJ denotes unclear
T1251 837-847 NN denotes Interferon
T1252 848-858 JJ denotes regulatory
T1253 859-866 NN denotes factors
T1254 867-868 -LRB- denotes (
T1255 868-872 NN denotes IRFs
T1256 872-873 -RRB- denotes )
T1257 874-877 VB denotes are
T1258 878-879 DT denotes a
T1259 880-886 NN denotes family
T1260 887-889 IN denotes of
T1261 890-905 JJ denotes transcriptional
T1262 906-916 NN denotes regulators
T1263 917-924 VB denotes defined
T1264 925-927 IN denotes by
T1265 928-929 DT denotes a
T1266 930-944 JJ denotes characteristic
T1267 945-953 NN denotes homology
T1268 954-956 IN denotes in
T1269 957-962 PRP-DOLLAR- denotes their
T1270 963-974 JJ denotes DNA-binding
T1271 975-981 NN denotes domain
T1272 983-987 PRP denotes They
T1273 988-992 VB denotes play
T1274 993-995 DT denotes an
T1275 996-1005 JJ denotes important
T1276 1006-1010 NN denotes role
T1277 1011-1013 IN denotes in
T1278 1014-1017 DT denotes the
T1279 1018-1028 NN denotes regulation
T1280 1029-1031 IN denotes of
T1281 1032-1039 JJ denotes various
T1282 1040-1045 NN denotes genes
T1283 1046-1047 -LRB- denotes (
T1284 1047-1051 JJ denotes such
T1285 1052-1054 IN denotes as
T1286 1055-1059 NN denotes IFNs
T1287 1059-1060 -COMMA- denotes ,
T1288 1061-1073 NN denotes interleukins
T1289 1073-1074 -COMMA- denotes ,
T1290 1075-1078 NN denotes MHC
T1291 1079-1084 NN denotes class
T1292 1085-1089 NN denotes I/II
T1293 1089-1090 -RRB- denotes )
T1294 1090-1091 -COMMA- denotes ,
T1295 1092-1101 NN denotes apoptosis
T1296 1102-1105 CC denotes and
T1297 1106-1132 NN denotes differentiation/maturation
T1298 1133-1134 -LRB- denotes (
T1299 1134-1137 CD denotes 4–6
T1300 1137-1138 -RRB- denotes )
T1301 1140-1145 NN denotes IRF-4
T1302 1146-1147 -LRB- denotes (
T1303 1147-1167 NN denotes ICSAT/Pip/MUM1/LSIRF
T1304 1167-1168 -RRB- denotes )
T1305 1169-1171 VB denotes is
T1306 1172-1175 CD denotes one
T1307 1176-1182 NN denotes member
T1308 1183-1187 IN denotes with
T1309 1188-1192 RB denotes very
T1310 1193-1203 JJ denotes restricted
T1311 1204-1214 NN denotes expression
T1312 1215-1222 NN denotes pattern
T1313 1222-1223 -COLON- denotes :
T1314 1224-1237 RB denotes Predominately
T1315 1238-1240 NN denotes B-
T1316 1241-1244 CC denotes and
T1317 1245-1254 VB denotes activated
T1318 1255-1268 NN denotes T-lymphocytes
T1319 1269-1272 VB denotes are
T1320 1273-1278 NN denotes IRF-4
T1321 1279-1287 JJ denotes positive
T1322 1288-1289 -LRB- denotes (
T1323 1289-1293 CD denotes 7–11
T1324 1293-1294 -RRB- denotes )
T1325 1296-1298 IN denotes In
T1326 1299-1307 NN denotes contrast
T1327 1308-1310 TO denotes to
T1328 1311-1316 JJ denotes other
T1329 1317-1321 NN denotes IRFs
T1330 1321-1322 -COMMA- denotes ,
T1331 1323-1333 NN denotes expression
T1332 1334-1336 IN denotes of
T1333 1337-1342 NN denotes IRF-4
T1334 1343-1346 MD denotes can
T1335 1346-1349 RB denotes not
T1336 1350-1352 VB denotes be
T1337 1353-1360 VB denotes induced
T1338 1361-1363 IN denotes by
T1339 1364-1368 NN denotes IFNs
T1340 1368-1369 -COMMA- denotes ,
T1341 1370-1373 CC denotes but
T1342 1374-1376 IN denotes by
T1343 1377-1384 NN denotes antigen
T1344 1385-1396 NN denotes stimulation
T1345 1396-1397 -COMMA- denotes ,
T1346 1398-1410 NN denotes crosslinking
T1347 1411-1413 IN denotes of
T1348 1414-1416 NN denotes T-
T1349 1417-1419 CC denotes or
T1350 1420-1426 NN denotes B-cell
T1351 1427-1436 NN denotes receptors
T1352 1437-1439 CC denotes or
T1353 1440-1465 NN denotes phorbol-myristate-acetate
T1354 1466-1467 -LRB- denotes (
T1355 1467-1472 CD denotes 10,11
T1356 1472-1473 -RRB- denotes )
T1357 1475-1485 JJ denotes Consistent
T1358 1486-1490 IN denotes with
T1359 1491-1494 DT denotes the
T1360 1495-1506 NN denotes restriction
T1361 1507-1509 IN denotes of
T1362 1510-1520 NN denotes expression
T1363 1521-1523 TO denotes to
T1364 1524-1539 JJ denotes immunocompetent
T1365 1540-1545 NN denotes cells
T1366 1545-1546 -COMMA- denotes ,
T1367 1547-1551 NN denotes mice
T1368 1552-1556 IN denotes with
T1369 1557-1565 NN denotes deletion
T1370 1566-1568 IN denotes of
T1371 1569-1574 NN denotes IRF-4
T1372 1575-1581 VB denotes failed
T1373 1582-1584 TO denotes to
T1374 1585-1592 VB denotes develop
T1375 1593-1599 JJ denotes mature
T1376 1600-1603 CC denotes and
T1377 1604-1616 RB denotes functionally
T1378 1617-1623 JJ denotes active
T1379 1624-1626 NN denotes B-
T1380 1627-1630 CC denotes and
T1381 1631-1644 NN denotes T-lymphocytes
T1382 1645-1646 -LRB- denotes (
T1383 1646-1648 CD denotes 12
T1384 1648-1649 -RRB- denotes )
T1385 1649-1650 -COMMA- denotes ,
T1386 1651-1654 CC denotes and
T1387 1655-1658 DT denotes the
T1388 1659-1667 JJ denotes impaired
T1389 1668-1678 NN denotes expression
T1390 1679-1681 IN denotes of
T1391 1682-1687 NN denotes IRF-4
T1392 1688-1690 IN denotes in
T1393 1691-1694 NN denotes CML
T1394 1695-1698 VB denotes was
T1395 1699-1712 RB denotes predominately
T1396 1713-1718 VB denotes found
T1397 1719-1721 IN denotes in
T1398 1722-1729 NN denotes T-cells
T1399 1730-1731 -LRB- denotes (
T1400 1731-1732 CD denotes 3
T1401 1732-1733 -RRB- denotes )
T1402 1735-1740 DT denotes These
T1403 1741-1745 NN denotes data
T1404 1746-1753 VB denotes suggest
T1405 1754-1755 DT denotes a
T1406 1756-1763 JJ denotes crucial
T1407 1764-1768 NN denotes role
T1408 1769-1772 IN denotes for
T1409 1773-1778 NN denotes IRF-4
T1410 1779-1781 IN denotes in
T1411 1782-1785 DT denotes the
T1412 1786-1794 NN denotes function
T1413 1795-1797 IN denotes of
T1414 1798-1804 JJ denotes immune
T1415 1805-1810 NN denotes cells
T1416 1812-1823 NN denotes Methylation
T1417 1824-1826 IN denotes of
T1418 1827-1839 NN denotes dinucleotide
T1419 1840-1858 NN denotes cytosine-guanosine
T1420 1859-1865 NN denotes motifs
T1421 1866-1867 -LRB- denotes (
T1422 1867-1870 NN denotes CpG
T1423 1870-1871 -RRB- denotes )
T1424 1871-1872 -COMMA- denotes ,
T1425 1873-1883 RB denotes especially
T1426 1884-1886 IN denotes in
T1427 1887-1890 NN denotes CpG
T1428 1891-1898 NN denotes islands
T1429 1899-1906 VB denotes located
T1430 1907-1909 IN denotes in
T1431 1910-1918 NN denotes promoter
T1432 1919-1926 NN denotes regions
T1433 1926-1927 -COMMA- denotes ,
T1434 1928-1930 VB denotes is
T1435 1931-1934 CD denotes one
T1436 1935-1937 IN denotes of
T1437 1938-1941 DT denotes the
T1438 1942-1952 NN denotes mechanisms
T1439 1953-1955 IN denotes of
T1440 1956-1960 NN denotes gene
T1441 1961-1971 NN denotes regulation
T1442 1972-1974 IN denotes in
T1443 1975-1982 NN denotes mammals
T1444 1983-1986 CC denotes and
T1445 1987-1988 DT denotes a
T1446 1989-1995 JJ denotes common
T1447 1996-2001 NN denotes event
T1448 2002-2004 IN denotes of
T1449 2005-2009 NN denotes gene
T1450 2010-2019 NN denotes silencing
T1451 2020-2022 IN denotes in
T1452 2023-2028 JJ denotes human
T1453 2029-2039 NN denotes neoplasias
T1454 2040-2041 -LRB- denotes (
T1455 2041-2046 CD denotes 13,14
T1456 2046-2047 -RRB- denotes )
T1457 2049-2051 IN denotes As
T1458 2052-2059 VB denotes opposed
T1459 2060-2062 TO denotes to
T1460 2063-2069 JJ denotes normal
T1461 2070-2075 NN denotes cells
T1462 2075-2076 -COMMA- denotes ,
T1463 2077-2093 NN denotes hypermethylation
T1464 2094-2096 IN denotes of
T1465 2097-2100 NN denotes CpG
T1466 2101-2108 NN denotes islands
T1467 2109-2111 VB denotes is
T1468 2112-2113 DT denotes a
T1469 2114-2124 RB denotes frequently
T1470 2125-2133 VB denotes observed
T1471 2134-2144 NN denotes phenomenon
T1472 2145-2147 IN denotes in
T1473 2148-2153 DT denotes every
T1474 2154-2160 NN denotes cancer
T1475 2161-2165 NN denotes type
T1476 2167-2169 FW denotes De
T1477 2170-2174 FW denotes novo
T1478 2175-2178 NN denotes DNA
T1479 2179-2190 NN denotes methylation
T1480 2191-2193 IN denotes of
T1481 2194-2199 NN denotes genes
T1482 2200-2204 JJ denotes such
T1483 2205-2207 IN denotes as
T1484 2208-2212 NN denotes cell
T1485 2213-2218 NN denotes cycle
T1486 2218-2219 -COMMA- denotes ,
T1487 2220-2223 NN denotes DNA
T1488 2224-2230 NN denotes repair
T1489 2230-2231 -COMMA- denotes ,
T1490 2232-2241 NN denotes apoptosis
T1491 2242-2245 CC denotes and
T1492 2246-2251 NN denotes tumor
T1493 2252-2262 NN denotes suppressor
T1494 2263-2268 NN denotes genes
T1495 2269-2271 VB denotes is
T1496 2272-2281 RB denotes therefore
T1497 2282-2289 VB denotes thought
T1498 2290-2292 TO denotes to
T1499 2293-2295 VB denotes be
T1500 2296-2304 VB denotes involved
T1501 2305-2307 IN denotes in
T1502 2308-2321 NN denotes tumorigenesis
T1503 2322-2323 -LRB- denotes (
T1504 2323-2328 CD denotes 15–17
T1505 2328-2329 -RRB- denotes )
T1506 2331-2339 NN denotes Examples
T1507 2340-2343 IN denotes for
T1508 2344-2348 JJ denotes such
T1509 2349-2358 JJ denotes aberrated
T1510 2359-2364 NN denotes genes
T1511 2365-2368 VB denotes are
T1512 2369-2373 NNP denotes MGMT
T1513 2373-2374 -COMMA- denotes ,
T1514 2375-2379 NNP denotes DAPK
T1515 2379-2380 -COMMA- denotes ,
T1516 2381-2387 NN denotes p14ARF
T1517 2387-2388 -COMMA- denotes ,
T1518 2389-2397 NN denotes p15INK4b
T1519 2397-2398 -COMMA- denotes ,
T1520 2399-2407 NN denotes p16INK4a
T1521 2407-2408 -COMMA- denotes ,
T1522 2409-2414 NN denotes BRCA1
T1523 2414-2415 -COMMA- denotes ,
T1524 2416-2421 NN denotes CDH13
T1525 2422-2425 CC denotes and
T1526 2426-2432 NN denotes APAF-1
T1527 2433-2434 -LRB- denotes (
T1528 2434-2439 CD denotes 17–19
T1529 2439-2440 -RRB- denotes )
T1530 2442-2444 IN denotes In
T1531 2445-2448 NN denotes CML
T1532 2448-2449 -COMMA- denotes ,
T1533 2450-2461 NN denotes methylation
T1534 2462-2464 VB denotes is
T1535 2465-2470 VB denotes known
T1536 2471-2473 TO denotes to
T1537 2474-2482 VB denotes regulate
T1538 2483-2493 NN denotes expression
T1539 2494-2496 IN denotes of
T1540 2497-2500 DT denotes the
T1541 2501-2506 NN denotes c-abl
T1542 2506-2507 -COMMA- denotes ,
T1543 2508-2511 DT denotes the
T1544 2512-2515 NN denotes bcr
T1545 2516-2520 NN denotes gene
T1546 2521-2524 CC denotes and
T1547 2525-2531 NN denotes others
T1548 2532-2533 -LRB- denotes (
T1549 2533-2538 CD denotes 20–23
T1550 2538-2539 -RRB- denotes )
T1551 2539-2540 -COMMA- denotes ,
T1552 2541-2544 CC denotes and
T1553 2545-2548 DT denotes the
T1554 2549-2555 NN denotes extent
T1555 2556-2558 IN denotes of
T1556 2559-2570 NN denotes methylation
T1557 2571-2573 IN denotes in
T1558 2574-2577 DT denotes the
T1559 2578-2583 NN denotes c-abl
T1560 2584-2592 NN denotes promoter
T1561 2593-2596 VB denotes has
T1562 2597-2601 VB denotes been
T1563 2602-2607 VB denotes shown
T1564 2608-2610 TO denotes to
T1565 2611-2613 VB denotes be
T1566 2614-2624 VB denotes associated
T1567 2625-2629 IN denotes with
T1568 2630-2638 VB denotes advanced
T1569 2639-2646 NN denotes disease
T1570 2647-2648 -LRB- denotes (
T1571 2648-2650 CD denotes 24
T1572 2650-2651 -RRB- denotes )
T1573 2653-2669 NN denotes Hypermethylation
T1574 2670-2673 IN denotes due
T1575 2674-2676 TO denotes to
T1576 2677-2691 NN denotes overexpression
T1577 2692-2694 IN denotes of
T1578 2695-2698 NN denotes DNA
T1579 2699-2717 NN denotes methyltransferases
T1580 2718-2719 -LRB- denotes (
T1581 2719-2724 NN denotes DNMTs
T1582 2724-2725 -RRB- denotes )
T1583 2726-2733 VB denotes remains
T1584 2734-2737 CD denotes one
T1585 2738-2746 JJ denotes possible
T1586 2747-2758 NN denotes explanation
T1587 2759-2762 IN denotes for
T1588 2763-2765 FW denotes de
T1589 2766-2770 FW denotes novo
T1590 2771-2782 NN denotes methylation
T1591 2783-2785 IN denotes in
T1592 2786-2799 NN denotes tumorigenesis
T1593 2801-2809 RB denotes Recently
T1594 2809-2810 -COMMA- denotes ,
T1595 2811-2816 NN denotes DNMTs
T1596 2817-2821 VB denotes have
T1597 2822-2826 VB denotes been
T1598 2827-2832 VB denotes shown
T1599 2833-2835 TO denotes to
T1600 2836-2838 VB denotes be
T1601 2839-2851 VB denotes up-regulated
T1602 2852-2854 IN denotes in
T1603 2855-2868 JJ denotes hematopoietic
T1604 2869-2881 NN denotes malignancies
T1605 2882-2883 -LRB- denotes (
T1606 2883-2885 CD denotes 25
T1607 2885-2886 -RRB- denotes )
T1608 2888-2906 JJ denotes Methyl-CpG-binding
T1609 2907-2915 NN denotes proteins
T1610 2916-2917 -LRB- denotes (
T1611 2917-2921 NN denotes MBPs
T1612 2921-2922 -RRB- denotes )
T1613 2923-2926 VB denotes are
T1614 2927-2934 VB denotes thought
T1615 2935-2937 TO denotes to
T1616 2938-2945 VB denotes inhibit
T1617 2946-2949 DT denotes the
T1618 2950-2957 NN denotes binding
T1619 2958-2960 IN denotes of
T1620 2961-2976 JJ denotes transcriptional
T1621 2977-2984 NN denotes factors
T1622 2985-2987 TO denotes to
T1623 2988-2991 DT denotes the
T1624 2992-3000 NN denotes promoter
T1625 3001-3004 CC denotes and
T1626 3005-3008 VB denotes are
T1627 3009-3018 RB denotes therefore
T1628 3019-3028 VB denotes discussed
T1629 3029-3031 IN denotes as
T1630 3032-3035 CD denotes one
T1631 3036-3045 NN denotes mechanism
T1632 3046-3048 IN denotes of
T1633 3049-3062 NN denotes transcription
T1634 3063-3073 NN denotes inhibition
T1635 3074-3076 IN denotes by
T1636 3077-3093 NN denotes hypermethylation
T1637 3094-3095 -LRB- denotes (
T1638 3095-3097 CD denotes 26
T1639 3097-3098 -RRB- denotes )
T1640 3100-3102 IN denotes In
T1641 3103-3107 DT denotes this
T1642 3108-3112 NN denotes work
T1643 3112-3113 -COMMA- denotes ,
T1644 3114-3116 PRP denotes we
T1645 3117-3124 VB denotes studied
T1646 3125-3135 NN denotes mechanisms
T1647 3136-3138 IN denotes of
T1648 3139-3144 NN denotes IRF-4
T1649 3145-3149 NN denotes gene
T1650 3150-3160 NN denotes expression
T1651 3161-3170 NN denotes silencing
T1652 3171-3173 IN denotes in
T1653 3174-3182 JJ denotes leukemic
T1654 3183-3188 NN denotes cells
T1655 3190-3192 PRP denotes We
T1656 3193-3201 VB denotes analyzed
T1657 3202-3205 DT denotes the
T1658 3206-3211 NN denotes IRF-4
T1659 3212-3220 NN denotes promoter
T1660 3221-3227 NN denotes region
T1661 3228-3231 IN denotes for
T1662 3232-3239 JJ denotes genetic
T1663 3240-3251 NN denotes aberrations
T1664 3252-3255 CC denotes and
T1665 3256-3269 JJ denotes methylational
T1666 3270-3276 NN denotes status
T1667 3277-3279 IN denotes in
T1668 3280-3294 JJ denotes IRF-4-positive
T1669 3295-3298 CC denotes and
T1670 3299-3308 JJ denotes -negative
T1671 3309-3322 JJ denotes hematopoietic
T1672 3323-3328 NN denotes cells
T2710 3354-3358 NN denotes Cell
T2711 3359-3364 NN denotes lines
T2712 3365-3370 NN denotes K-562
T2713 3370-3371 -COMMA- denotes ,
T2714 3372-3378 NN denotes Jurkat
T2715 3379-3382 CC denotes and
T2716 3383-3388 NN denotes U-937
T2717 3389-3393 VB denotes were
T2718 3394-3402 VB denotes obtained
T2719 3403-3407 IN denotes from
T2720 3408-3411 DT denotes the
T2721 3412-3416 NN denotes ATCC
T2722 3417-3418 -LRB- denotes (
T2723 3418-3426 JJ denotes American
T2724 3427-3431 NN denotes Type
T2725 3432-3439 NNP denotes Culture
T2726 3440-3450 NNP denotes Collection
T2727 3450-3451 -COMMA- denotes ,
T2728 3452-3461 NNP denotes Rockville
T2729 3461-3462 -COMMA- denotes ,
T2730 3463-3466 NNP denotes USA
T2731 3466-3467 -RRB- denotes )
T2732 3468-3471 CC denotes and
T2733 3472-3476 NN denotes EM-2
T2734 3476-3477 -COMMA- denotes ,
T2735 3478-3485 NN denotes LAMA-84
T2736 3485-3486 -COMMA- denotes ,
T2737 3487-3493 NN denotes CML-T1
T2738 3493-3494 -COMMA- denotes ,
T2739 3495-3501 NN denotes BV-173
T2740 3501-3502 -COMMA- denotes ,
T2741 3503-3507 NN denotes SD-1
T2742 3508-3511 CC denotes and
T2743 3512-3521 NN denotes RPMI-8226
T2744 3522-3526 IN denotes from
T2745 3527-3530 DT denotes the
T2746 3531-3535 NN denotes DSMZ
T2747 3536-3537 -LRB- denotes (
T2748 3537-3545 NNP denotes Deutsche
T2749 3546-3554 NNP denotes Sammlung
T2750 3555-3558 NNP denotes von
T2751 3559-3574 NNP denotes Mikroorganismen
T2752 3575-3578 VB denotes und
T2753 3579-3591 NNP denotes Zellkulturen
T2754 3592-3596 NNP denotes GmbH
T2755 3596-3597 -COMMA- denotes ,
T2756 3598-3610 NNP denotes Braunschweig
T2757 3610-3611 -COMMA- denotes ,
T2758 3612-3619 NNP denotes Germany
T2759 3619-3620 -RRB- denotes )
T2760 3622-3625 DT denotes All
T2761 3626-3630 NN denotes cell
T2762 3631-3636 NN denotes lines
T2763 3636-3637 -COMMA- denotes ,
T2764 3638-3644 IN denotes except
T2765 3645-3651 NN denotes BV-173
T2766 3651-3652 -COMMA- denotes ,
T2767 3653-3657 NN denotes SD-1
T2768 3658-3661 CC denotes and
T2769 3662-3671 NN denotes RPMI-8226
T2770 3671-3672 -COMMA- denotes ,
T2771 3673-3677 VB denotes were
T2772 3678-3692 JJ denotes IRF-4-negative
T2862 3695-3699 NN denotes Cell
T2863 3700-3707 NN denotes culture
T2864 3708-3711 CC denotes and
T2865 3712-3723 NN denotes stimulation
T2866 3724-3727 DT denotes All
T2867 3728-3732 NN denotes cell
T2868 3733-3738 NN denotes lines
T2869 3739-3743 VB denotes were
T2870 3744-3754 VB denotes maintained
T2871 3755-3757 IN denotes at
T2872 3758-3759 CD denotes 5
T2873 3759-3760 NN denotes %
T2874 3761-3764 NN denotes CO2
T2875 3765-3767 IN denotes in
T2876 3768-3772 NN denotes RPMI
T2877 3773-3777 CD denotes 1640
T2878 3778-3784 NN denotes medium
T2879 3785-3789 IN denotes with
T2880 3790-3791 CD denotes 1
T2881 3791-3792 NN denotes %
T2882 3793-3802 NN denotes glutamine
T2883 3803-3804 -LRB- denotes (
T2884 3804-3813 NNP denotes Gibco/BRL
T2885 3814-3824 NNP denotes Eggenstein
T2886 3824-3825 -COMMA- denotes ,
T2887 3826-3833 NNP denotes Germany
T2888 3833-3834 -RRB- denotes )
T2889 3835-3847 VB denotes supplemented
T2890 3848-3852 IN denotes with
T2891 3853-3855 CD denotes 10
T2892 3855-3856 NN denotes %
T2893 3857-3862 JJ denotes fetal
T2894 3863-3867 NN denotes calf
T2895 3868-3873 NN denotes serum
T2896 3874-3875 -LRB- denotes (
T2897 3875-3884 NN denotes Gibco/BRL
T2898 3884-3885 -RRB- denotes )
T2899 3885-3886 -COMMA- denotes ,
T2900 3887-3888 CD denotes 1
T2901 3888-3889 NN denotes %
T2902 3890-3913 NN denotes penicillin/streptomycin
T2903 3914-3915 -LRB- denotes (
T2904 3915-3923 NNP denotes Biochrom
T2905 3923-3924 -COMMA- denotes ,
T2906 3925-3931 NNP denotes Berlin
T2907 3931-3932 -COMMA- denotes ,
T2908 3933-3940 NNP denotes Germany
T2909 3940-3941 -RRB- denotes )
T2910 3943-3947 WRB denotes When
T2911 3948-3957 VB denotes indicated
T2912 3957-3958 -COMMA- denotes ,
T2913 3959-3964 NN denotes cells
T2914 3965-3969 VB denotes were
T2915 3970-3977 VB denotes treated
T2916 3978-3982 IN denotes with
T2917 3983-4004 NN denotes 5-aza-2-deoxycytidine
T2918 4005-4006 -LRB- denotes (
T2919 4006-4011 NN denotes AzadC
T2920 4011-4012 -RRB- denotes )
T2921 4013-4015 CC denotes or
T2922 4016-4029 NN denotes 5-azacytidine
T2923 4030-4031 -LRB- denotes (
T2924 4031-4035 NN denotes AzaC
T2925 4035-4036 -RRB- denotes )
T2926 4037-4038 -LRB- denotes (
T2927 4038-4043 NNP denotes Sigma
T2928 4043-4044 -COMMA- denotes ,
T2929 4045-4056 NNP denotes Taufkirchen
T2930 4056-4057 -COMMA- denotes ,
T2931 4058-4065 NNP denotes Germany
T2932 4065-4066 -RRB- denotes )
T2933 4067-4070 IN denotes for
T2934 4071-4080 JJ denotes different
T2935 4081-4085 NN denotes time
T2936 4086-4093 NN denotes periods
T2937 4095-4100 VB denotes Owing
T2938 4101-4103 TO denotes to
T2939 4104-4109 PRP-DOLLAR- denotes their
T2940 4110-4118 JJ denotes chemical
T2941 4119-4130 NN denotes instability
T2942 4131-4136 JJ denotes fresh
T2943 4137-4147 NN denotes substances
T2944 4148-4152 VB denotes were
T2945 4153-4161 JJ denotes re-added
T2946 4162-4167 DT denotes every
T2947 4168-4170 CD denotes 24
T2948 4171-4172 NN denotes h
T3062 4175-4185 NN denotes Sequencing
T3063 4186-4188 IN denotes of
T3064 4189-4192 DT denotes the
T3065 4193-4198 NN denotes IRF-4
T3066 4199-4207 NN denotes promoter
T3067 4208-4211 IN denotes For
T3068 4212-4220 NN denotes analysis
T3069 4221-4223 IN denotes of
T3070 4224-4227 DT denotes the
T3071 4228-4233 NN denotes IRF-4
T3072 4234-4242 NN denotes promoter
T3073 4243-4249 NN denotes region
T3074 4250-4253 IN denotes for
T3075 4254-4263 JJ denotes permanent
T3076 4264-4275 NN denotes aberrations
T3077 4276-4280 JJ denotes such
T3078 4281-4283 IN denotes as
T3079 4284-4304 NN denotes insertions/deletions
T3080 4305-4307 CC denotes or
T3081 4308-4316 NN denotes mutation
T3082 4316-4317 -COMMA- denotes ,
T3083 4318-4320 PRP denotes we
T3084 4321-4334 VB denotes PCR-amplified
T3085 4335-4338 CD denotes two
T3086 4339-4348 NN denotes fragments
T3087 4349-4353 IN denotes from
T3088 4354-4361 JJ denotes genomic
T3089 4362-4365 NN denotes DNA
T3090 4365-4366 -COMMA- denotes ,
T3091 4367-4372 WDT denotes which
T3092 4373-4376 VB denotes was
T3093 4377-4386 VB denotes extracted
T3094 4387-4391 IN denotes from
T3095 4392-4400 VB denotes depicted
T3096 4401-4405 NN denotes cell
T3097 4406-4411 NN denotes lines
T3098 4412-4416 IN denotes with
T3099 4417-4418 DT denotes a
T3100 4419-4429 JJ denotes commercial
T3101 4430-4433 NN denotes kit
T3102 4434-4435 -LRB- denotes (
T3103 4435-4441 NN denotes Qiagen
T3104 4441-4442 -COMMA- denotes ,
T3105 4443-4448 NNP denotes Hilde
T3106 4448-4449 -COMMA- denotes ,
T3107 4450-4457 NNP denotes Germany
T3108 4457-4458 -RRB- denotes )
T3109 4459-4461 IN denotes as
T3110 4462-4473 VB denotes recommended
T3111 4475-4478 DT denotes The
T3112 4479-4486 NN denotes primers
T3113 4487-4491 VB denotes were
T3114 4492-4501 JJ denotes 1-forward
T3115 4501-4502 -COLON- denotes :
T3116 4503-4531 JJ denotes 5′-TTGAGATGGAGTCTTGCTCTGT-3′
T3117 4531-4532 -COMMA- denotes ,
T3118 4533-4542 JJ denotes 1-reverse
T3119 4542-4543 -COLON- denotes :
T3120 4544-4573 NN denotes 5′-CCAGGACCTCAGGAGGCCAGTCA-3′
T3121 4573-4574 -COLON- denotes ;
T3122 4575-4584 CD denotes 2-forward
T3123 4584-4585 -COLON- denotes :
T3124 4586-4617 JJ denotes 5′-AGCGGTGAAACTGAGAGTGCGAGGT-3′
T3125 4617-4618 -COMMA- denotes ,
T3126 4619-4628 JJ denotes 2-reverse
T3127 4628-4629 -COLON- denotes :
T3128 4630-4656 NN denotes 5′-GCCACATCGCTGCAGTTTAG-3′
T3129 4658-4661 DT denotes The
T3130 4662-4670 NN denotes products
T3131 4671-4675 VB denotes were
T3132 4676-4682 VB denotes cloned
T3133 4683-4687 IN denotes with
T3134 4688-4691 DT denotes the
T3135 4692-4697 NN denotes ‘TOPO
T3136 4698-4700 NN denotes TA
T3137 4701-4708 NN denotes cloning
T3138 4709-4713 NN denotes kit’
T3139 4714-4715 -LRB- denotes (
T3140 4715-4725 NN denotes Invitrogen
T3141 4725-4726 -COMMA- denotes ,
T3142 4727-4736 NN denotes Groningen
T3143 4736-4737 -COMMA- denotes ,
T3144 4738-4741 DT denotes The
T3145 4742-4753 NNP denotes Netherlands
T3146 4753-4754 -RRB- denotes )
T3147 4756-4761 IN denotes After
T3148 4762-4771 JJ denotes bacterial
T3149 4772-4785 NN denotes amplification
T3150 4786-4788 IN denotes of
T3151 4789-4792 DT denotes the
T3152 4793-4799 VB denotes cloned
T3153 4800-4803 NN denotes PCR
T3154 4804-4813 NN denotes fragments
T3155 4814-4816 IN denotes by
T3156 4817-4825 JJ denotes standard
T3157 4826-4836 NN denotes procedures
T3158 4836-4837 -COMMA- denotes ,
T3159 4838-4840 IN denotes at
T3160 4841-4846 JJ denotes least
T3161 4847-4852 CD denotes three
T3162 4853-4859 NN denotes clones
T3163 4860-4864 IN denotes from
T3164 4865-4869 DT denotes each
T3165 4870-4876 NN denotes sample
T3166 4877-4881 VB denotes were
T3167 4882-4891 VB denotes sequenced
T3168 4892-4896 IN denotes with
T3169 4897-4899 DT denotes an
T3170 4900-4909 VB denotes automated
T3171 4910-4919 NN denotes sequencer
T3172 4920-4921 -LRB- denotes (
T3173 4921-4924 NNP denotes ABI
T3174 4925-4930 NNP denotes Prism
T3175 4931-4934 CD denotes 377
T3176 4934-4935 -COMMA- denotes ,
T3177 4936-4943 NNP denotes Applied
T3178 4944-4955 NNP denotes Bio-systems
T3179 4955-4956 -COMMA- denotes ,
T3180 4957-4963 NNP denotes Foster
T3181 4964-4968 NNP denotes City
T3182 4968-4969 -COMMA- denotes ,
T3183 4970-4973 NNP denotes USA
T3184 4973-4974 -RRB- denotes )
T3185 4975-4977 IN denotes as
T3186 4978-4989 VB denotes recommended
T3187 4990-4992 IN denotes by
T3188 4993-4996 DT denotes the
T3189 4997-5009 NN denotes manufacturer
T3450 5012-5022 NN denotes Expression
T3451 5023-5031 NN denotes analysis
T3452 5032-5034 TO denotes To
T3453 5035-5042 VB denotes analyze
T3454 5043-5046 DT denotes the
T3455 5047-5052 NN denotes IRF-4
T3456 5053-5068 JJ denotes transcriptional
T3457 5069-5074 NN denotes level
T3458 5074-5075 -COMMA- denotes ,
T3459 5076-5079 NN denotes RNA
T3460 5080-5083 VB denotes was
T3461 5084-5093 VB denotes extracted
T3462 5094-5098 IN denotes from
T3463 5099-5104 NN denotes cells
T3464 5105-5110 VB denotes using
T3465 5111-5114 DT denotes the
T3466 5115-5125 JJ denotes commercial
T3467 5126-5136 NN denotes RNAzol-kit
T3468 5137-5138 -LRB- denotes (
T3469 5138-5144 NNP denotes Paesel
T3470 5144-5145 -COMMA- denotes ,
T3471 5146-5155 NNP denotes Frankfurt
T3472 5155-5156 -COMMA- denotes ,
T3473 5157-5164 NNP denotes Germany
T3474 5164-5165 -RRB- denotes )
T3475 5167-5169 DT denotes An
T3476 5170-5177 NN denotes aliquot
T3477 5178-5180 IN denotes of
T3478 5181-5182 CD denotes 1
T3479 5183-5185 NN denotes μg
T3480 5186-5191 JJ denotes total
T3481 5192-5195 NN denotes RNA
T3482 5196-5199 VB denotes was
T3483 5200-5204 VB denotes used
T3484 5205-5208 IN denotes for
T3485 5209-5213 NN denotes cDNA
T3486 5214-5223 NN denotes synthesis
T3487 5224-5226 IN denotes as
T3488 5227-5236 VB denotes described
T3489 5237-5247 RB denotes previously
T3490 5248-5249 -LRB- denotes (
T3491 5249-5251 CD denotes 27
T3492 5251-5252 -RRB- denotes )
T3493 5254-5257 NN denotes RNA
T3494 5258-5268 NN denotes expression
T3495 5269-5277 NN denotes analysis
T3496 5278-5281 IN denotes for
T3497 5282-5287 NN denotes IRF-4
T3498 5288-5291 CC denotes and
T3499 5292-5295 DT denotes the
T3500 5296-5305 NN denotes reference
T3501 5306-5310 NN denotes gene
T3502 5311-5318 NN denotes β-actin
T3503 5319-5322 VB denotes was
T3504 5323-5330 VB denotes carried
T3505 5331-5334 RP denotes out
T3506 5335-5337 IN denotes by
T3507 5338-5355 JJ denotes semi-quantitative
T3508 5356-5359 NN denotes PCR
T3509 5360-5362 IN denotes as
T3510 5363-5372 VB denotes described
T3511 5373-5383 RB denotes previously
T3512 5384-5385 -LRB- denotes (
T3513 5385-5389 CD denotes 3,27
T3514 5389-5390 -RRB- denotes )
T3515 5392-5395 NN denotes PCR
T3516 5396-5404 NN denotes products
T3517 5405-5409 VB denotes were
T3518 5410-5418 VB denotes verified
T3519 5419-5421 IN denotes by
T3520 5422-5431 VB denotes automated
T3521 5432-5442 NN denotes sequencing
T3522 5444-5447 NN denotes PCR
T3523 5448-5455 NN denotes primers
T3524 5456-5459 CC denotes and
T3525 5460-5470 NN denotes conditions
T3526 5471-5474 IN denotes for
T3527 5475-5485 NN denotes expression
T3528 5486-5494 NN denotes analysis
T3529 5495-5497 IN denotes of
T3530 5498-5502 NN denotes DNMT
T3531 5503-5505 CC denotes or
T3532 5506-5509 NN denotes MBP
T3533 5510-5511 -LRB- denotes (
T3534 5511-5516 NN denotes DNMT1
T3535 5517-5523 NN denotes DNMT3A
T3536 5523-5524 -COMMA- denotes ,
T3537 5525-5531 NN denotes DNMT3B
T3538 5531-5532 -COMMA- denotes ,
T3539 5533-5537 NN denotes MeCP
T3540 5537-5538 -COMMA- denotes ,
T3541 5539-5543 NN denotes MBD1
T3542 5543-5544 -COMMA- denotes ,
T3543 5545-5549 NN denotes MBD2
T3544 5550-5553 CC denotes and
T3545 5554-5558 NN denotes MBD4
T3546 5558-5559 -RRB- denotes )
T3547 5560-5564 VB denotes were
T3548 5565-5574 VB denotes published
T3549 5575-5584 RB denotes elsewhere
T3550 5585-5586 -LRB- denotes (
T3551 5586-5588 CD denotes 28
T3552 5588-5589 -RRB- denotes )
T3553 5591-5594 IN denotes For
T3554 5595-5603 NN denotes analysis
T3555 5604-5606 IN denotes of
T3556 5607-5612 NN denotes IRF-4
T3557 5613-5620 NN denotes protein
T3558 5621-5631 NN denotes expression
T3559 5631-5632 -COMMA- denotes ,
T3560 5633-5634 DT denotes a
T3561 5635-5643 JJ denotes standard
T3562 5644-5658 NN denotes immunoblotting
T3563 5659-5664 NN denotes assay
T3564 5665-5668 VB denotes was
T3565 5669-5678 VB denotes performed
T3566 5679-5681 IN denotes as
T3567 5682-5691 VB denotes described
T3568 5692-5702 RB denotes previously
T3569 5703-5704 -LRB- denotes (
T3570 5704-5706 CD denotes 29
T3571 5706-5707 -RRB- denotes )
T3572 5709-5716 RB denotes Briefly
T3573 5716-5717 -COMMA- denotes ,
T3574 5718-5725 NN denotes protein
T3575 5726-5733 NN denotes lysates
T3576 5734-5738 VB denotes were
T3577 5739-5748 VB denotes generated
T3578 5749-5751 IN denotes by
T3579 5752-5762 VB denotes incubating
T3580 5763-5764 CD denotes 1
T3581 5765-5766 NN denotes ×
T3582 5767-5770 CD denotes 106
T3583 5771-5776 NN denotes cells
T3584 5777-5779 IN denotes in
T3585 5780-5783 CD denotes 100
T3586 5784-5786 NN denotes µl
T3587 5787-5791 NN denotes RIPA
T3588 5792-5798 NN denotes buffer
T3589 5799-5800 -LRB- denotes (
T3590 5800-5801 CD denotes 1
T3591 5801-5802 NN denotes %
T3592 5803-5808 NN denotes NP-40
T3593 5808-5809 -COMMA- denotes ,
T3594 5810-5813 CD denotes 0.5
T3595 5813-5814 NN denotes %
T3596 5815-5834 NN denotes sodiumdesoxycholate
T3597 5834-5835 -COMMA- denotes ,
T3598 5836-5839 CD denotes 0.1
T3599 5839-5840 NN denotes %
T3600 5841-5844 NN denotes SDS
T3601 5844-5845 -COMMA- denotes ,
T3602 5846-5849 CD denotes 100
T3603 5850-5855 NN denotes µg/ml
T3604 5856-5876 NN denotes phenylmethylsulfonyl
T3605 5877-5885 NN denotes fluoride
T3606 5885-5886 -COMMA- denotes ,
T3607 5887-5889 CD denotes 10
T3608 5890-5895 NN denotes µl/ml
T3609 5896-5919 NN denotes protease-inhibitory-mix
T3610 5919-5920 -COMMA- denotes ,
T3611 5921-5922 CD denotes 1
T3612 5923-5930 NN denotes µmol/ml
T3613 5931-5950 NN denotes sodiumorthovanadate
T3614 5951-5953 IN denotes in
T3615 5954-5972 JJ denotes phosphate-buffered
T3616 5973-5979 NN denotes saline
T3617 5979-5980 -RRB- denotes )
T3618 5981-5984 IN denotes for
T3619 5985-5987 CD denotes 30
T3620 5988-5991 NN denotes min
T3621 5992-5994 IN denotes on
T3622 5995-5998 NN denotes ice
T3623 6000-6005 IN denotes After
T3624 6006-6020 NN denotes centrifugation
T3625 6020-6021 -COMMA- denotes ,
T3626 6022-6029 NN denotes protein
T3627 6030-6043 NN denotes concentration
T3628 6044-6046 IN denotes of
T3629 6047-6050 DT denotes the
T3630 6051-6062 NN denotes supernatant
T3631 6063-6066 VB denotes was
T3632 6067-6077 VB denotes determined
T3633 6078-6080 IN denotes by
T3634 6081-6091 NN denotes BCA-method
T3635 6092-6093 -LRB- denotes (
T3636 6093-6099 NNP denotes Pierce
T3637 6099-6100 -COMMA- denotes ,
T3638 6101-6109 NNP denotes Rockford
T3639 6109-6110 -COMMA- denotes ,
T3640 6111-6113 NN denotes IL
T3641 6113-6114 -RRB- denotes )
T3642 6115-6117 IN denotes as
T3643 6118-6129 VB denotes recommended
T3644 6131-6138 NN denotes Protein
T3645 6139-6146 NN denotes lysates
T3646 6147-6148 -LRB- denotes (
T3647 6148-6154 CD denotes 70–100
T3648 6155-6157 NN denotes µg
T3649 6157-6158 -RRB- denotes )
T3650 6159-6163 VB denotes were
T3651 6164-6179 VB denotes electrophoresed
T3652 6180-6182 IN denotes on
T3653 6183-6197 NN denotes polyacrylamide
T3654 6198-6202 NN denotes gels
T3655 6203-6206 CC denotes and
T3656 6207-6218 VB denotes transferred
T3657 6219-6221 TO denotes to
T3658 6222-6223 DT denotes a
T3659 6224-6237 NN denotes PVDF-membrane
T3660 6238-6239 -LRB- denotes (
T3661 6239-6248 NNP denotes Immobilon
T3662 6249-6250 NNP denotes P
T3663 6250-6251 -COMMA- denotes ,
T3664 6252-6256 CD denotes 0.45
T3665 6257-6259 NN denotes µm
T3666 6259-6260 -COLON- denotes ;
T3667 6261-6270 NNP denotes Millipore
T3668 6270-6271 -COMMA- denotes ,
T3669 6272-6280 NNP denotes Eschborn
T3670 6280-6281 -COMMA- denotes ,
T3671 6282-6289 NNP denotes Germany
T3672 6289-6290 -RRB- denotes )
T3673 6292-6301 NN denotes Membranes
T3674 6302-6306 VB denotes were
T3675 6307-6314 VB denotes blocked
T3676 6315-6319 IN denotes with
T3677 6320-6323 CD denotes 2.5
T3678 6323-6324 NN denotes %
T3679 6325-6333 VB denotes blocking
T3680 6334-6341 NN denotes reagent
T3681 6342-6343 -LRB- denotes (
T3682 6343-6353 NNP denotes Boehringer
T3683 6354-6362 NNP denotes Mannheim
T3684 6362-6363 -COMMA- denotes ,
T3685 6364-6371 NNP denotes Germany
T3686 6371-6372 -RRB- denotes )
T3687 6373-6375 IN denotes in
T3688 6376-6380 NN denotes TBST
T3689 6381-6387 NN denotes buffer
T3690 6388-6389 -LRB- denotes (
T3691 6389-6393 CD denotes 4.44
T3692 6394-6397 NN denotes g/l
T3693 6398-6406 NN denotes Tris–HCL
T3694 6406-6407 -COMMA- denotes ,
T3695 6408-6412 CD denotes 2.65
T3696 6413-6416 NN denotes g/l
T3697 6417-6423 NN denotes TrisOH
T3698 6423-6424 -COMMA- denotes ,
T3699 6425-6429 CD denotes 8.07
T3700 6430-6433 NN denotes g/l
T3701 6434-6438 NN denotes NaCl
T3702 6438-6439 -COMMA- denotes ,
T3703 6440-6443 CD denotes 0.2
T3704 6444-6447 NN denotes g/l
T3705 6448-6451 NN denotes KCl
T3706 6452-6455 CC denotes and
T3707 6456-6459 CD denotes 500
T3708 6460-6464 VB denotes µl/l
T3709 6465-6473 CD denotes Tween-20
T3710 6474-6476 IN denotes in
T3711 6477-6480 NN denotes H2O
T3712 6480-6481 -RRB- denotes )
T3713 6482-6485 CC denotes and
T3714 6486-6498 RB denotes subsequently
T3715 6499-6508 VB denotes incubated
T3716 6509-6513 IN denotes with
T3717 6514-6521 JJ denotes primary
T3718 6522-6530 NN denotes antibody
T3719 6531-6533 IN denotes as
T3720 6534-6543 VB denotes indicated
T3721 6544-6547 CC denotes and
T3722 6548-6559 JJ denotes horseradish
T3723 6560-6581 JJ denotes peroxidase-conjugated
T3724 6582-6591 JJ denotes secondary
T3725 6592-6600 NN denotes antibody
T3726 6600-6601 -COMMA- denotes ,
T3727 6602-6612 JJ denotes anti-mouse
T3728 6613-6615 CC denotes or
T3729 6616-6625 JJ denotes anti-goat
T3730 6626-6629 NN denotes IgG
T3731 6630-6631 -LRB- denotes (
T3732 6631-6635 NNP denotes DAKO
T3733 6635-6636 -COMMA- denotes ,
T3734 6637-6644 NNP denotes Hamburg
T3735 6644-6645 -COMMA- denotes ,
T3736 6646-6653 NNP denotes Germany
T3737 6653-6654 -RRB- denotes )
T3738 6654-6655 -COMMA- denotes ,
T3739 6656-6668 RB denotes respectively
T3740 6670-6673 DT denotes The
T3741 6674-6683 NN denotes membranes
T3742 6684-6688 VB denotes were
T3743 6689-6693 RB denotes then
T3744 6694-6703 VB denotes developed
T3745 6704-6708 IN denotes with
T3746 6709-6711 DT denotes an
T3747 6712-6715 NN denotes ECL
T3748 6716-6725 NN denotes detection
T3749 6726-6729 NN denotes kit
T3750 6730-6731 -LRB- denotes (
T3751 6731-6739 NNP denotes Amersham
T3752 6740-6749 NNP denotes Pharmacia
T3753 6750-6757 NNP denotes Biotech
T3754 6757-6758 -COMMA- denotes ,
T3755 6759-6767 NNP denotes Freiburg
T3756 6767-6768 -COMMA- denotes ,
T3757 6769-6776 NNP denotes Germany
T3758 6776-6777 -RRB- denotes )
T3759 6779-6782 DT denotes The
T3760 6783-6790 JJ denotes primary
T3761 6791-6801 NN denotes antibodies
T3762 6802-6806 VB denotes were
T3763 6807-6811 NN denotes goat
T3764 6812-6828 NN denotes anti-IRF-4/ICSAT
T3765 6829-6830 -LRB- denotes (
T3766 6830-6834 NN denotes M-17
T3767 6834-6835 -RRB- denotes )
T3768 6836-6837 -LRB- denotes (
T3769 6837-6842 NNP denotes Santa
T3770 6843-6847 NNP denotes Cruz
T3771 6848-6861 NNP denotes Biotechnology
T3772 6861-6862 -COMMA- denotes ,
T3773 6863-6868 NNP denotes Santa
T3774 6869-6873 NNP denotes Cruz
T3775 6873-6874 -COMMA- denotes ,
T3776 6875-6877 NN denotes CA
T3777 6877-6878 -RRB- denotes )
T3778 6879-6882 CC denotes and
T3779 6883-6888 NN denotes mouse
T3780 6889-6901 JJ denotes anti-β-actin
T3781 6902-6903 -LRB- denotes (
T3782 6903-6908 NN denotes AC-74
T3783 6908-6909 -RRB- denotes )
T3784 6910-6911 -LRB- denotes (
T3785 6911-6916 NN denotes Sigma
T3786 6916-6917 -RRB- denotes )
T4371 6920-6940 JJ denotes Methylation-specific
T4372 6941-6962 NN denotes restriction-PCR-assay
T4373 6963-6966 NN denotes DNA
T4374 6967-6970 VB denotes was
T4375 6971-6980 VB denotes extracted
T4376 6981-6985 IN denotes with
T4377 6986-6987 DT denotes a
T4378 6988-6998 JJ denotes commercial
T4379 6999-7002 NN denotes kit
T4380 7003-7004 -LRB- denotes (
T4381 7004-7010 NN denotes Qiagen
T4382 7010-7011 -RRB- denotes )
T4383 7012-7014 IN denotes as
T4384 7015-7026 VB denotes recommended
T4385 7028-7033 IN denotes Since
T4386 7034-7037 DT denotes the
T4387 7038-7049 NN denotes restriction
T4388 7050-7057 NN denotes ability
T4389 7058-7060 IN denotes of
T4390 7061-7068 JJ denotes several
T4391 7069-7082 NN denotes endonucleases
T4392 7083-7085 VB denotes is
T4393 7086-7095 VB denotes inhibited
T4394 7096-7098 IN denotes by
T4395 7099-7110 NN denotes methylation
T4396 7111-7113 IN denotes of
T4397 7114-7119 PRP-DOLLAR- denotes their
T4398 7120-7126 NN denotes target
T4399 7127-7135 NN denotes sequence
T4400 7135-7136 -COMMA- denotes ,
T4401 7137-7139 PRP denotes we
T4402 7140-7144 VB denotes used
T4403 7145-7166 JJ denotes methylation-sensitive
T4404 7167-7174 NN denotes enzymes
T4405 7175-7180 NN denotes HpaII
T4406 7181-7184 CC denotes and
T4407 7185-7202 NN denotes HaeII-isochizomer
T4408 7203-7211 NN denotes Bsp143II
T4409 7212-7215 CC denotes and
T4410 7216-7224 NN denotes Bsh1236I
T4411 7225-7226 -LRB- denotes (
T4412 7226-7229 NNP denotes MBI
T4413 7230-7239 NNP denotes Fermentas
T4414 7239-7240 -COMMA- denotes ,
T4415 7241-7243 NNP denotes St
T4416 7244-7252 NNP denotes Leon-Rot
T4417 7252-7253 -COMMA- denotes ,
T4418 7254-7261 NNP denotes Germany
T4419 7261-7262 -RRB- denotes )
T4420 7263-7264 -LRB- denotes (
T4421 7264-7269 CD denotes 20,24
T4422 7269-7270 -RRB- denotes )
T4423 7272-7274 IN denotes As
T4424 7275-7282 VB denotes control
T4425 7283-7286 DT denotes the
T4426 7287-7308 JJ denotes methylation-resistant
T4427 7309-7315 NN denotes enzyme
T4428 7316-7320 NN denotes MspI
T4429 7321-7324 CC denotes and
T4430 7325-7327 DT denotes an
T4431 7328-7334 NN denotes enzyme
T4432 7335-7339 IN denotes with
T4433 7340-7342 DT denotes no
T4434 7343-7354 NN denotes recognition
T4435 7355-7359 NN denotes site
T4436 7360-7362 IN denotes in
T4437 7363-7366 DT denotes the
T4438 7367-7373 NN denotes target
T4439 7374-7382 NN denotes promoter
T4440 7382-7383 -COMMA- denotes ,
T4441 7384-7389 NN denotes EcoRI
T4442 7389-7390 -COMMA- denotes ,
T4443 7391-7395 VB denotes were
T4444 7396-7400 VB denotes used
T4445 7402-7405 NN denotes DNA
T4446 7406-7407 -LRB- denotes (
T4447 7407-7410 CD denotes 0.8
T4448 7411-7413 NN denotes µg
T4449 7413-7414 -RRB- denotes )
T4450 7415-7418 VB denotes was
T4451 7419-7427 VB denotes digested
T4452 7428-7430 IN denotes by
T4453 7431-7433 CD denotes 40
T4454 7434-7435 NN denotes U
T4455 7436-7439 DT denotes the
T4456 7440-7450 JJ denotes respective
T4457 7451-7457 NN denotes enzyme
T4458 7458-7461 IN denotes for
T4459 7462-7463 CD denotes 6
T4460 7464-7465 NN denotes h
T4461 7466-7469 CC denotes and
T4462 7469-7470 -COMMA- denotes ,
T4463 7471-7473 TO denotes to
T4464 7474-7480 VB denotes ensure
T4465 7481-7489 JJ denotes complete
T4466 7490-7498 NN denotes cleavage
T4467 7498-7499 -COMMA- denotes ,
T4468 7500-7510 JJ denotes additional
T4469 7511-7513 CD denotes 20
T4470 7514-7515 NN denotes U
T4471 7516-7519 IN denotes for
T4472 7520-7522 CD denotes 16
T4473 7523-7524 NN denotes h
T4474 7526-7536 RB denotes Thereafter
T4475 7537-7540 CD denotes 100
T4476 7541-7543 NN denotes ng
T4477 7544-7546 IN denotes of
T4478 7547-7555 JJ denotes digested
T4479 7556-7559 NN denotes DNA
T4480 7560-7563 VB denotes was
T4481 7564-7568 VB denotes used
T4482 7569-7571 TO denotes to
T4483 7572-7573 DT denotes a
T4484 7574-7577 NN denotes PCR
T4485 7578-7591 NN denotes amplification
T4486 7592-7594 IN denotes of
T4487 7595-7598 CD denotes two
T4488 7599-7608 NN denotes fragments
T4489 7609-7610 -LRB- denotes (
T4490 7610-7612 NN denotes F1
T4491 7613-7616 CC denotes and
T4492 7617-7619 NN denotes F2
T4493 7619-7620 -RRB- denotes )
T4494 7621-7629 VB denotes spanning
T4495 7630-7634 NN denotes part
T4496 7635-7637 IN denotes of
T4497 7638-7641 DT denotes the
T4498 7642-7647 NN denotes IRF-4
T4499 7648-7656 NN denotes promoter
T4500 7657-7658 -LRB- denotes (
T4501 7658-7660 CD denotes 30
T4502 7660-7661 -RRB- denotes )
T4503 7662-7663 -LRB- denotes (
T4504 7663-7670 NN denotes GenBank
T4505 7671-7677 NN denotes U52683
T4506 7677-7678 -COLON- denotes ;
T4507 7679-7682 VB denotes see
T4508 7683-7689 NN denotes Figure
T4509 7690-7692 NN denotes 3A
T4510 7692-7693 -RRB- denotes )
T4511 7695-7698 DT denotes The
T4512 7699-7708 NN denotes sequences
T4513 7709-7711 IN denotes of
T4514 7712-7715 DT denotes the
T4515 7716-7723 NN denotes primers
T4516 7724-7728 VB denotes were
T4517 7729-7739 JJ denotes F1-forward
T4518 7739-7740 -COLON- denotes :
T4519 7741-7769 JJ denotes 5′-TTGAGATGGAGTCTTGCTCTGT-3′
T4520 7769-7770 -COMMA- denotes ,
T4521 7771-7781 JJ denotes F1-reverse
T4522 7781-7782 -COLON- denotes :
T4523 7783-7811 NN denotes ATCACTTCCAGACTTCAGTTCACCT-3′
T4524 7812-7813 -LRB- denotes (
T4525 7813-7816 CD denotes 341
T4526 7817-7819 NN denotes bp
T4527 7819-7820 -RRB- denotes )
T4528 7820-7821 -COLON- denotes ;
T4529 7822-7832 JJ denotes F2-forward
T4530 7832-7833 -COLON- denotes :
T4531 7834-7865 JJ denotes 5′-AAGGTGAACTGAAGTCTGGAAGTGA-3′
T4532 7865-7866 -COMMA- denotes ,
T4533 7867-7877 JJ denotes F2-reverse
T4534 7877-7878 -COLON- denotes :
T4535 7879-7908 NN denotes 5′-CCAGGACCTCAGGAGGCCAGTCA-3′
T4536 7909-7910 -LRB- denotes (
T4537 7910-7913 CD denotes 474
T4538 7914-7916 NN denotes bp
T4539 7916-7917 -RRB- denotes )
T4540 7919-7922 DT denotes The
T4541 7923-7926 NN denotes PCR
T4542 7927-7937 NN denotes conditions
T4543 7938-7942 VB denotes were
T4544 7943-7952 VB denotes described
T4545 7953-7962 RB denotes elsewhere
T4546 7963-7964 -LRB- denotes (
T4547 7964-7965 CD denotes 3
T4548 7965-7966 -RRB- denotes )
T4549 7968-7971 NN denotes PCR
T4550 7972-7975 VB denotes was
T4551 7976-7985 VB denotes performed
T4552 7986-7990 IN denotes with
T4553 7991-7993 DT denotes an
T4554 7994-8003 JJ denotes annealing
T4555 8004-8015 NN denotes temperature
T4556 8016-8018 IN denotes of
T4557 8019-8023 NN denotes 62°C
T4558 8024-8027 CC denotes and
T4559 8028-8030 CD denotes 35
T4560 8031-8037 NN denotes cycles
T4561 8039-8043 WRB denotes When
T4562 8044-8047 NN denotes DNA
T4563 8048-8051 VB denotes was
T4564 8052-8062 VB denotes methylated
T4565 8063-8065 IN denotes at
T4566 8066-8074 JJ denotes specific
T4567 8075-8080 NN denotes sites
T4568 8080-8081 -COMMA- denotes ,
T4569 8082-8085 DT denotes the
T4570 8086-8095 JJ denotes sensitive
T4571 8096-8103 NN denotes enzymes
T4572 8104-8108 VB denotes were
T4573 8109-8112 RB denotes not
T4574 8113-8117 JJ denotes able
T4575 8118-8120 TO denotes to
T4576 8121-8127 VB denotes digest
T4577 8128-8131 DT denotes the
T4578 8132-8135 NN denotes DNA
T4579 8136-8139 CC denotes and
T4580 8140-8153 NN denotes amplification
T4581 8154-8158 VB denotes took
T4582 8159-8164 NN denotes place
T4583 8164-8165 -COLON- denotes ;
T4584 8166-8168 IN denotes in
T4585 8169-8173 NN denotes case
T4586 8174-8176 IN denotes of
T4587 8177-8179 DT denotes no
T4588 8180-8191 NN denotes methylation
T4589 8191-8192 -COMMA- denotes ,
T4590 8193-8196 NN denotes DNA
T4591 8197-8200 VB denotes was
T4592 8201-8209 VB denotes digested
T4593 8210-8213 CC denotes and
T4594 8214-8216 DT denotes no
T4595 8217-8224 NN denotes product
T4596 8225-8228 VB denotes was
T4597 8229-8238 VB denotes generated
T4598 8240-8243 DT denotes The
T4599 8244-8247 NN denotes PCR
T4600 8248-8256 NN denotes products
T4601 8257-8261 VB denotes were
T4602 8262-8277 VB denotes electrophoresed
T4603 8278-8280 IN denotes on
T4604 8281-8282 DT denotes a
T4605 8283-8284 CD denotes 3
T4606 8284-8285 NN denotes %
T4607 8286-8293 NN denotes agarose
T4608 8294-8297 NN denotes gel
T4609 8297-8298 -COMMA- denotes ,
T4610 8299-8303 VB denotes were
T4611 8304-8311 VB denotes stained
T4612 8312-8316 IN denotes with
T4613 8317-8325 NN denotes ethidium
T4614 8326-8333 NN denotes bromide
T4615 8334-8337 CC denotes and
T4616 8338-8350 VB denotes photographed
T4617 8352-8355 NN denotes PCR
T4618 8356-8364 NN denotes products
T4619 8365-8369 VB denotes were
T4620 8370-8378 VB denotes verified
T4621 8379-8381 IN denotes by
T4622 8382-8391 VB denotes automated
T4623 8392-8402 NN denotes sequencing
T4943 8405-8414 NN denotes Bisulfite
T4944 8415-8424 NN denotes treatment
T4945 8425-8428 NN denotes DNA
T4946 8429-8432 VB denotes was
T4947 8433-8442 VB denotes extracted
T4948 8443-8445 IN denotes as
T4949 8446-8455 VB denotes described
T4950 8456-8461 RB denotes above
T4951 8463-8472 NN denotes Bisulfite
T4952 8473-8482 NN denotes treatment
T4953 8483-8485 IN denotes of
T4954 8486-8489 NN denotes DNA
T4955 8489-8490 -COMMA- denotes ,
T4956 8491-8498 VB denotes leading
T4957 8499-8501 TO denotes to
T4958 8502-8512 NN denotes conversion
T4959 8513-8515 IN denotes of
T4960 8516-8528 JJ denotes unmethylated
T4961 8529-8537 NN denotes cytosine
T4962 8538-8540 TO denotes to
T4963 8541-8547 NN denotes uracil
T4964 8548-8556 NN denotes residues
T4965 8557-8560 CC denotes and
T4966 8561-8563 DT denotes no
T4967 8564-8570 NN denotes change
T4968 8571-8573 IN denotes of
T4969 8574-8584 VB denotes methylated
T4970 8585-8593 NN denotes cytosine
T4971 8594-8602 NN denotes residues
T4972 8602-8603 -COMMA- denotes ,
T4973 8604-8607 VB denotes was
T4974 8608-8617 VB denotes performed
T4975 8618-8620 IN denotes as
T4976 8621-8630 VB denotes described
T4977 8631-8633 IN denotes as
T4978 8634-8641 VB denotes follows
T4979 8643-8650 RB denotes Briefly
T4980 8650-8651 -COMMA- denotes ,
T4981 8652-8653 CD denotes 1
T4982 8654-8656 NN denotes µg
T4983 8657-8659 IN denotes of
T4984 8660-8663 NN denotes DNA
T4985 8664-8667 CC denotes and
T4986 8668-8669 CD denotes 2
T4987 8670-8672 NN denotes µg
T4988 8673-8675 IN denotes of
T4989 8676-8680 NN denotes poly
T4990 8680-8681 -LRB- denotes (
T4991 8681-8686 NN denotes dA–dT
T4992 8686-8687 -RRB- denotes )
T4993 8687-8688 -LRB- denotes (
T4994 8688-8692 NN denotes poly
T4995 8692-8693 -LRB- denotes (
T4996 8693-8698 NN denotes dA–dT
T4997 8698-8699 -RRB- denotes )
T4998 8700-8710 NN denotes copolymers
T4999 8711-8712 -LRB- denotes (
T5000 8712-8720 NNP denotes Amersham
T5001 8721-8730 NNP denotes Pharmacia
T5002 8731-8738 NNP denotes Biotech
T5003 8738-8739 -RRB- denotes )
T5004 8740-8744 VB denotes were
T5005 8745-8756 VB denotes denaturated
T5006 8757-8760 IN denotes for
T5007 8761-8763 CD denotes 20
T5008 8764-8767 NN denotes min
T5009 8768-8770 IN denotes at
T5010 8771-8775 NN denotes 42°C
T5011 8776-8778 IN denotes in
T5012 8779-8782 CD denotes 0.3
T5013 8783-8784 NN denotes M
T5014 8785-8789 NN denotes NaOH
T5015 8790-8792 IN denotes in
T5016 8793-8794 DT denotes a
T5017 8795-8801 NN denotes volume
T5018 8802-8804 IN denotes of
T5019 8805-8807 CD denotes 50
T5020 8808-8810 NN denotes µl
T5021 8812-8817 JJ denotes Fresh
T5022 8818-8827 NN denotes solutions
T5023 8828-8830 IN denotes of
T5024 8831-8833 CD denotes 30
T5025 8834-8836 NN denotes µl
T5026 8837-8839 IN denotes of
T5027 8840-8842 CD denotes 10
T5028 8843-8845 NN denotes mM
T5029 8846-8857 NN denotes hydrochinon
T5030 8858-8859 -LRB- denotes (
T5031 8859-8864 NN denotes Sigma
T5032 8864-8865 -RRB- denotes )
T5033 8866-8869 CC denotes and
T5034 8870-8873 CD denotes 530
T5035 8874-8876 NN denotes µl
T5036 8877-8879 IN denotes of
T5037 8880-8881 CD denotes 3
T5038 8882-8883 NN denotes M
T5039 8884-8890 NN denotes sodium
T5040 8891-8900 NN denotes bisulfite
T5041 8901-8902 -LRB- denotes (
T5042 8902-8904 NN denotes pH
T5043 8905-8908 CD denotes 5.0
T5044 8908-8909 -COLON- denotes ;
T5045 8910-8915 NNP denotes Sigma
T5046 8915-8916 -RRB- denotes )
T5047 8917-8921 VB denotes were
T5048 8922-8927 VB denotes added
T5049 8927-8928 -COMMA- denotes ,
T5050 8929-8932 DT denotes the
T5051 8933-8941 NN denotes solution
T5052 8942-8945 VB denotes was
T5053 8946-8952 RB denotes gently
T5054 8953-8958 VB denotes mixed
T5055 8958-8959 -COMMA- denotes ,
T5056 8960-8969 VB denotes overlayed
T5057 8970-8974 IN denotes with
T5058 8975-8982 NN denotes mineral
T5059 8983-8986 NN denotes oil
T5060 8987-8990 CC denotes and
T5061 8991-9000 VB denotes incubated
T5062 9001-9003 IN denotes in
T5063 9004-9007 DT denotes the
T5064 9008-9012 NN denotes dark
T5065 9013-9016 IN denotes for
T5066 9017-9022 CD denotes 12–13
T5067 9023-9024 NN denotes h
T5068 9025-9027 IN denotes at
T5069 9028-9033 NNP denotes 50°C.
T5070 9034-9037 DT denotes The
T5071 9038-9045 JJ denotes aqueous
T5072 9046-9051 NN denotes phase
T5073 9052-9055 VB denotes was
T5074 9056-9065 VB denotes recovered
T5075 9066-9071 VB denotes using
T5076 9072-9075 DT denotes the
T5077 9076-9083 NNP denotes ‘Wizard
T5078 9084-9087 NN denotes DNA
T5079 9088-9096 NN denotes clean-up
T5080 9097-9104 NN denotes system’
T5081 9105-9106 -LRB- denotes (
T5082 9106-9113 NNP denotes Promega
T5083 9113-9114 -COMMA- denotes ,
T5084 9115-9123 NNP denotes Mannheim
T5085 9123-9124 -COMMA- denotes ,
T5086 9125-9132 NNP denotes Germany
T5087 9132-9133 -RRB- denotes )
T5088 9135-9138 DT denotes The
T5089 9139-9147 VB denotes purified
T5090 9148-9151 NN denotes DNA
T5091 9152-9155 VB denotes was
T5092 9156-9168 RB denotes subsequently
T5093 9169-9174 VB denotes mixed
T5094 9175-9179 IN denotes with
T5095 9180-9181 CD denotes 1
T5096 9182-9183 NN denotes M
T5097 9184-9188 NN denotes NaOH
T5098 9189-9191 TO denotes to
T5099 9192-9193 DT denotes a
T5100 9194-9199 JJ denotes final
T5101 9200-9213 NN denotes concentration
T5102 9214-9216 IN denotes of
T5103 9217-9220 CD denotes 0.3
T5104 9221-9222 NN denotes M
T5105 9223-9226 CC denotes and
T5106 9227-9236 VB denotes incubated
T5107 9237-9240 IN denotes for
T5108 9241-9243 CD denotes 20
T5109 9244-9247 NN denotes min
T5110 9248-9250 IN denotes at
T5111 9251-9255 NN denotes 37°C
T5112 9256-9258 TO denotes to
T5113 9259-9265 VB denotes ensure
T5114 9266-9274 JJ denotes complete
T5115 9275-9290 NN denotes desulfonisation
T5116 9292-9295 NN denotes DNA
T5117 9296-9299 VB denotes was
T5118 9300-9307 NN denotes ethanol
T5119 9308-9320 VB denotes precipitated
T5120 9321-9323 IN denotes in
T5121 9324-9327 DT denotes the
T5122 9328-9336 NN denotes presence
T5123 9337-9339 IN denotes of
T5124 9340-9344 CD denotes 1/10
T5125 9345-9348 NN denotes vol
T5126 9349-9351 IN denotes of
T5127 9352-9353 CD denotes 3
T5128 9354-9355 NN denotes M
T5129 9356-9362 NN denotes sodium
T5130 9363-9370 NN denotes acetate
T5131 9370-9371 -COMMA- denotes ,
T5132 9372-9378 VB denotes washed
T5133 9379-9383 IN denotes with
T5134 9384-9386 CD denotes 70
T5135 9386-9387 NN denotes %
T5136 9388-9395 NN denotes ethanol
T5137 9396-9399 CC denotes and
T5138 9400-9411 VB denotes resuspended
T5139 9412-9414 IN denotes in
T5140 9415-9417 CD denotes 50
T5141 9418-9420 NN denotes µl
T5142 9421-9424 NN denotes H2O
T5143 9426-9436 JJ denotes Subsequent
T5144 9437-9440 NN denotes PCR
T5145 9441-9454 NN denotes amplification
T5146 9455-9457 IN denotes of
T5147 9458-9459 CD denotes 4
T5148 9460-9462 NN denotes µl
T5149 9463-9480 JJ denotes bisulfite-treated
T5150 9481-9484 NN denotes DNA
T5151 9485-9488 VB denotes was
T5152 9489-9493 VB denotes used
T5153 9494-9497 IN denotes for
T5154 9498-9505 NN denotes cloning
T5155 9506-9508 IN denotes of
T5156 9509-9512 CD denotes two
T5157 9513-9522 NN denotes fragments
T5158 9523-9525 IN denotes of
T5159 9526-9529 DT denotes the
T5160 9530-9535 NN denotes IRF-4
T5161 9536-9544 NN denotes promoter
T5162 9545-9546 -LRB- denotes (
T5163 9546-9550 NN denotes BS-I
T5164 9551-9554 CC denotes and
T5165 9555-9560 NN denotes BS-II
T5166 9560-9561 -RRB- denotes )
T5167 9562-9566 IN denotes into
T5168 9567-9573 NN denotes pCR2.1
T5169 9574-9580 NN denotes vector
T5170 9581-9585 IN denotes with
T5171 9586-9589 DT denotes the
T5172 9590-9595 NN denotes ‘TOPO
T5173 9596-9598 NN denotes TA
T5174 9599-9606 NN denotes cloning
T5175 9607-9611 NN denotes kit’
T5176 9612-9613 -LRB- denotes (
T5177 9613-9623 NN denotes Invitrogen
T5178 9623-9624 -RRB- denotes )
T5179 9625-9626 -LRB- denotes (
T5180 9626-9629 VB denotes see
T5181 9630-9636 NN denotes Figure
T5182 9637-9639 NN denotes 3A
T5183 9639-9640 -RRB- denotes )
T5184 9642-9645 DT denotes The
T5185 9646-9653 NN denotes primers
T5186 9654-9658 VB denotes used
T5187 9659-9662 IN denotes for
T5188 9663-9666 NN denotes PCR
T5189 9667-9680 NN denotes amplification
T5190 9681-9683 IN denotes of
T5191 9684-9687 DT denotes the
T5192 9688-9692 NN denotes BS-I
T5193 9693-9696 CC denotes and
T5194 9697-9702 NN denotes BS-II
T5195 9703-9712 NN denotes fragments
T5196 9713-9720 VB denotes contain
T5197 9721-9724 DT denotes the
T5198 9725-9733 JJ denotes putative
T5199 9734-9741 JJ denotes altered
T5200 9742-9750 NN denotes sequence
T5201 9751-9753 IN denotes of
T5202 9754-9757 DT denotes the
T5203 9758-9763 NN denotes sense
T5204 9764-9770 NN denotes strand
T5205 9771-9774 JJ denotes due
T5206 9775-9777 TO denotes to
T5207 9778-9787 VB denotes bisulfite
T5208 9788-9797 NN denotes treatment
T5209 9798-9799 -LRB- denotes (
T5210 9799-9808 VB denotes converted
T5211 9809-9817 NN denotes cytosine
T5212 9818-9826 NN denotes residues
T5213 9827-9830 VB denotes are
T5214 9831-9838 VB denotes written
T5215 9839-9841 IN denotes in
T5216 9842-9846 JJ denotes bold
T5217 9847-9854 NN denotes letters
T5218 9854-9855 -RRB- denotes )
T5219 9855-9856 -COLON- denotes :
T5220 9857-9869 JJ denotes BS-I-forward
T5221 9870-9903 NN denotes 5′-TATTTGGATTTTTAGGGAGTTTTTTTT-3′
T5222 9903-9904 -COMMA- denotes ,
T5223 9905-9917 JJ denotes BS-I-reverse
T5224 9918-9950 NN denotes 5′-ACCCAACTCCCTTAAACTATTAAACT-3′
T5225 9951-9952 -LRB- denotes (
T5226 9952-9955 CD denotes 187
T5227 9956-9958 NN denotes bp
T5228 9958-9959 -RRB- denotes )
T5229 9959-9960 -COLON- denotes ;
T5230 9961-9974 JJ denotes BS-II-forward
T5231 9975-10007 NN denotes 5′-AGTTTAATAGTTTAAGGGAGTTGGGT-3′
T5232 10007-10008 -COMMA- denotes ,
T5233 10009-10022 JJ denotes BS-II-reverse
T5234 10023-10055 NN denotes 5′-CTCACCCTAAACTCAAAACTAAAAAC-3′
T5235 10056-10057 -LRB- denotes (
T5236 10057-10060 CD denotes 674
T5237 10061-10063 NN denotes bp
T5238 10063-10064 -RRB- denotes )
T5239 10066-10071 IN denotes After
T5240 10072-10081 JJ denotes bacterial
T5241 10082-10095 NN denotes amplification
T5242 10096-10098 IN denotes of
T5243 10099-10102 DT denotes the
T5244 10103-10109 VB denotes cloned
T5245 10110-10113 NN denotes PCR
T5246 10114-10123 NN denotes fragments
T5247 10124-10126 IN denotes by
T5248 10127-10135 JJ denotes standard
T5249 10136-10146 NN denotes procedures
T5250 10146-10147 -COMMA- denotes ,
T5251 10148-10153 CD denotes eight
T5252 10154-10160 NN denotes clones
T5253 10161-10165 IN denotes from
T5254 10166-10170 DT denotes each
T5255 10171-10177 NN denotes sample
T5256 10178-10182 VB denotes were
T5257 10183-10192 VB denotes sequenced
T5258 10193-10197 IN denotes with
T5259 10198-10200 DT denotes an
T5260 10201-10210 VB denotes automated
T5261 10211-10220 NN denotes sequencer
T5262 10221-10222 -LRB- denotes (
T5263 10222-10225 NNP denotes ABI
T5264 10226-10231 NNP denotes Prism
T5265 10232-10235 CD denotes 377
T5266 10235-10236 -COMMA- denotes ,
T5267 10237-10244 NNP denotes Applied
T5268 10245-10255 NNP denotes Biosystems
T5269 10255-10256 -RRB- denotes )
T5701 10259-10261 FW denotes In
T5702 10262-10267 FW denotes vitro
T5703 10268-10279 NN denotes methylation
T5704 10280-10283 CC denotes and
T5705 10284-10292 NN denotes reporter
T5706 10293-10297 NN denotes gene
T5707 10298-10304 NN denotes assays
T5708 10305-10308 DT denotes The
T5709 10309-10314 NN denotes IRF-4
T5710 10315-10332 JJ denotes promoter-reporter
T5711 10333-10337 NN denotes gene
T5712 10338-10347 NN denotes construct
T5713 10348-10351 VB denotes was
T5714 10352-10362 RB denotes generously
T5715 10363-10371 VB denotes provided
T5716 10372-10374 IN denotes by
T5717 10375-10377 NNP denotes J.
T5718 10378-10385 NNP denotes Hiscott
T5719 10386-10387 -LRB- denotes (
T5720 10387-10389 CD denotes 31
T5721 10389-10390 -RRB- denotes )
T5722 10392-10402 NN denotes Constructs
T5723 10403-10407 VB denotes were
T5724 10408-10418 VB denotes methylated
T5725 10419-10421 FW denotes in
T5726 10422-10427 FW denotes vitro
T5727 10428-10432 IN denotes with
T5728 10433-10436 NN denotes CpG
T5729 10437-10446 NN denotes Methylase
T5730 10447-10448 -LRB- denotes (
T5731 10448-10453 NN denotes M.Sss
T5732 10454-10455 CD denotes I
T5733 10455-10456 -RRB- denotes )
T5734 10457-10459 IN denotes as
T5735 10460-10471 VB denotes recommended
T5736 10472-10474 IN denotes by
T5737 10475-10478 DT denotes the
T5738 10479-10491 NN denotes manufacturer
T5739 10492-10493 -LRB- denotes (
T5740 10493-10495 NN denotes NE
T5741 10496-10503 NN denotes Biolabs
T5742 10503-10504 -RRB- denotes )
T5743 10505-10508 CC denotes and
T5744 10509-10517 JJ denotes complete
T5745 10518-10529 NN denotes methylation
T5746 10530-10533 VB denotes was
T5747 10534-10541 VB denotes checked
T5748 10542-10545 IN denotes via
T5749 10546-10557 NN denotes restriction
T5750 10558-10566 NN denotes analysis
T5751 10567-10568 -LRB- denotes (
T5752 10568-10574 NN denotes Figure
T5753 10575-10577 NN denotes 5A
T5754 10577-10578 -RRB- denotes )
T5755 10580-10588 NN denotes Reporter
T5756 10589-10593 NN denotes gene
T5757 10594-10600 NN denotes assays
T5758 10601-10606 VB denotes using
T5759 10607-10610 DT denotes the
T5760 10611-10615 JJ denotes dual
T5761 10616-10626 NN denotes luciferase
T5762 10627-10632 NN denotes assay
T5763 10633-10634 -LRB- denotes (
T5764 10634-10641 NN denotes Promega
T5765 10641-10642 -RRB- denotes )
T5766 10643-10647 VB denotes were
T5767 10648-10657 VB denotes performed
T5768 10658-10665 JJ denotes similar
T5769 10666-10668 TO denotes to
T5770 10669-10677 JJ denotes previous
T5771 10678-10685 NN denotes reports
T5772 10686-10687 -LRB- denotes (
T5773 10687-10689 CD denotes 29
T5774 10689-10690 -RRB- denotes )
T5775 10692-10699 RB denotes Briefly
T5776 10699-10700 -COMMA- denotes ,
T5777 10701-10702 CD denotes 5
T5778 10703-10705 NN denotes nM
T5779 10706-10708 IN denotes of
T5780 10709-10712 DT denotes the
T5781 10713-10721 NN denotes reporter
T5782 10722-10731 NN denotes construct
T5783 10732-10735 CC denotes and
T5784 10736-10739 DT denotes the
T5785 10740-10752 NN denotes transfection
T5786 10753-10760 NN denotes control
T5787 10761-10770 NN denotes construct
T5788 10771-10781 VB denotes expressing
T5789 10782-10785 DT denotes the
T5790 10786-10793 NN denotes renilla
T5791 10794-10804 NN denotes luciferase
T5792 10805-10809 NN denotes gene
T5793 10810-10814 VB denotes were
T5794 10815-10838 VB denotes transientlyco-expressed
T5795 10839-10842 IN denotes via
T5796 10843-10858 NN denotes electroporation
T5797 10860-10863 DT denotes The
T5798 10864-10871 NN denotes control
T5799 10872-10881 NN denotes construct
T5800 10882-10888 VB denotes served
T5801 10889-10891 IN denotes as
T5802 10892-10894 DT denotes an
T5803 10895-10903 JJ denotes internal
T5804 10904-10913 NN denotes reference
T5805 10914-10917 IN denotes for
T5806 10918-10930 NN denotes transfection
T5807 10931-10941 NN denotes efficiency
T5808 10943-10954 CD denotes Forty-eight
T5809 10955-10960 NN denotes hours
T5810 10961-10966 IN denotes after
T5811 10967-10979 NN denotes transfection
T5812 10979-10980 -COMMA- denotes ,
T5813 10981-10991 NN denotes luciferase
T5814 10992-11000 NN denotes activity
T5815 11001-11004 VB denotes was
T5816 11005-11013 VB denotes measured
T5817 11014-11018 IN denotes with
T5818 11019-11020 DT denotes a
T5819 11021-11023 NN denotes LB
T5820 11024-11026 CD denotes 96
T5821 11027-11028 NN denotes P
T5822 11029-11039 NN denotes microlumat
T5823 11040-11041 -LRB- denotes (
T5824 11041-11043 NNP denotes EG
T5825 11043-11044 CC denotes &
T5826 11044-11045 NNP denotes G
T5827 11046-11054 NNP denotes Berthold
T5828 11054-11055 -COMMA- denotes ,
T5829 11056-11059 NNP denotes Bad
T5830 11060-11067 NNP denotes Wildbad
T5831 11067-11068 -COMMA- denotes ,
T5832 11069-11076 NNP denotes Germany
T5833 11076-11077 -RRB- denotes )
T5834 11079-11084 NN denotes IRF-4
T5835 11085-11093 NN denotes promoter
T5836 11094-11104 NN denotes activation
T5837 11105-11108 VB denotes was
T5838 11109-11119 VB denotes quantified
T5839 11120-11122 IN denotes as
T5840 11123-11124 DT denotes a
T5841 11125-11130 NN denotes ratio
T5842 11131-11133 IN denotes of
T5843 11134-11142 VB denotes measured
T5844 11143-11150 RB denotes firefly
T5845 11151-11156 JJ denotes light
T5846 11157-11162 NN denotes units
T5847 11163-11164 -LRB- denotes (
T5848 11164-11167 NN denotes flu
T5849 11167-11168 -RRB- denotes )
T5850 11169-11177 JJ denotes relative
T5851 11178-11180 TO denotes to
T5852 11181-11188 NN denotes renilla
T5853 11189-11190 -LRB- denotes (
T5854 11190-11193 NN denotes rlu
T5855 11193-11194 -RRB- denotes )
T5856 11196-11200 DT denotes Each
T5857 11201-11211 NN denotes experiment
T5858 11212-11215 VB denotes was
T5859 11216-11223 VB denotes carried
T5860 11224-11227 RP denotes out
T5861 11228-11230 IN denotes at
T5862 11231-11236 JJ denotes least
T5863 11237-11242 CD denotes three
T5864 11243-11248 NN denotes times
T6221 11260-11267 NN denotes Absence
T6222 11268-11270 IN denotes of
T6223 11271-11276 NN denotes IRF-4
T6224 11277-11287 NN denotes expression
T6225 11288-11290 IN denotes in
T6226 11291-11299 NN denotes leukemia
T6227 11300-11305 NN denotes cells
T6228 11306-11308 VB denotes is
T6229 11309-11312 RB denotes not
T6230 11313-11316 JJ denotes due
T6231 11317-11319 TO denotes to
T6232 11320-11328 NN denotes promoter
T6233 11329-11340 NN denotes alterations
T6234 11341-11343 PRP denotes We
T6235 11344-11348 VB denotes have
T6236 11349-11359 RB denotes previously
T6237 11360-11372 VB denotes demonstrated
T6238 11373-11374 DT denotes a
T6239 11375-11379 NN denotes lack
T6240 11380-11382 IN denotes of
T6241 11383-11388 NN denotes IRF-4
T6242 11389-11399 NN denotes expression
T6243 11400-11402 IN denotes in
T6244 11403-11411 NN denotes leukemia
T6245 11412-11420 NN denotes patients
T6246 11421-11424 CC denotes and
T6247 11425-11437 RB denotes specifically
T6248 11438-11440 IN denotes in
T6249 11441-11444 NN denotes CML
T6250 11445-11452 NN denotes T-cells
T6251 11453-11454 -LRB- denotes (
T6252 11454-11455 CD denotes 3
T6253 11455-11456 -RRB- denotes )
T6254 11458-11462 RB denotes Here
T6255 11462-11463 -COMMA- denotes ,
T6256 11464-11466 PRP denotes we
T6257 11467-11478 VB denotes demonstrate
T6258 11479-11482 DT denotes the
T6259 11483-11490 NN denotes absence
T6260 11491-11493 IN denotes of
T6261 11494-11499 NN denotes IRF-4
T6262 11500-11510 NN denotes expression
T6263 11511-11513 IN denotes in
T6264 11514-11521 JJ denotes various
T6265 11522-11535 JJ denotes hematopoietic
T6266 11536-11540 NN denotes cell
T6267 11541-11546 NN denotes lines
T6268 11546-11547 -COMMA- denotes ,
T6269 11548-11552 JJ denotes such
T6270 11553-11555 IN denotes as
T6271 11556-11562 NN denotes Jurkat
T6272 11562-11563 -COMMA- denotes ,
T6273 11564-11565 DT denotes a
T6274 11566-11572 NN denotes T-cell
T6275 11573-11581 NN denotes leukemia
T6276 11581-11582 -COMMA- denotes ,
T6277 11583-11589 NN denotes CML-T1
T6278 11589-11590 -COMMA- denotes ,
T6279 11591-11592 DT denotes a
T6280 11593-11609 JJ denotes bcr-abl-positive
T6281 11610-11616 NN denotes T-cell
T6282 11617-11621 NN denotes line
T6283 11621-11622 -COMMA- denotes ,
T6284 11623-11628 NN denotes K-562
T6285 11628-11629 -COMMA- denotes ,
T6286 11630-11631 DT denotes a
T6287 11632-11647 JJ denotes bcr-abl-positve
T6288 11648-11663 NN denotes erythroleukemia
T6289 11663-11664 -COMMA- denotes ,
T6290 11665-11670 NN denotes U-937
T6291 11670-11671 -COMMA- denotes ,
T6292 11672-11673 DT denotes a
T6293 11674-11683 JJ denotes monocytic
T6294 11684-11692 NN denotes leukemia
T6295 11692-11693 -COMMA- denotes ,
T6296 11694-11698 NN denotes EM-2
T6297 11699-11702 CC denotes and
T6298 11703-11710 NN denotes LAMA-84
T6299 11710-11711 -COMMA- denotes ,
T6300 11712-11727 JJ denotes bcr-abl-positve
T6301 11728-11735 JJ denotes myeloid
T6302 11736-11744 NN denotes leukemia
T6303 11744-11745 -COMMA- denotes ,
T6304 11746-11749 CC denotes but
T6305 11750-11753 RB denotes not
T6306 11754-11756 IN denotes in
T6307 11757-11761 NN denotes SD-1
T6308 11761-11762 -COMMA- denotes ,
T6309 11763-11764 DT denotes a
T6310 11765-11781 JJ denotes bcr-abl-positive
T6311 11782-11787 JJ denotes acute
T6312 11788-11801 JJ denotes lymphoblastic
T6313 11802-11810 NN denotes leukemia
T6314 11811-11812 -LRB- denotes (
T6315 11812-11815 JJ denotes pre
T6316 11816-11821 NN denotes B-ALL
T6317 11821-11822 -RRB- denotes )
T6318 11822-11823 -COMMA- denotes ,
T6319 11824-11833 NN denotes RPMI-8226
T6320 11833-11834 -COMMA- denotes ,
T6321 11835-11836 DT denotes a
T6322 11837-11845 JJ denotes multiple
T6323 11846-11853 NN denotes myeloma
T6324 11854-11857 CC denotes and
T6325 11858-11864 NN denotes BV-173
T6326 11864-11865 -COMMA- denotes ,
T6327 11866-11867 DT denotes a
T6328 11868-11884 JJ denotes bcr-abl-positive
T6329 11885-11891 NN denotes B-cell
T6330 11892-11896 NN denotes line
T6331 11897-11898 -LRB- denotes (
T6332 11898-11905 NN denotes Figures
T6333 11906-11908 NN denotes 1A
T6334 11909-11912 CC denotes and
T6335 11913-11915 NN denotes 5D
T6336 11915-11916 -RRB- denotes )
T6337 11918-11923 IN denotes After
T6338 11924-11934 NN denotes sequencing
T6339 11935-11937 IN denotes of
T6340 11938-11941 DT denotes the
T6341 11942-11947 NN denotes IRF-4
T6342 11948-11956 NN denotes promoter
T6343 11956-11957 -COMMA- denotes ,
T6344 11958-11960 PRP denotes it
T6345 11961-11966 MD denotes could
T6346 11967-11969 VB denotes be
T6347 11970-11978 VB denotes excluded
T6348 11979-11983 IN denotes that
T6349 11984-11991 NN denotes absence
T6350 11992-11994 IN denotes of
T6351 11995-12000 NN denotes IRF-4
T6352 12001-12011 NN denotes expression
T6353 12012-12014 IN denotes in
T6354 12015-12018 DT denotes any
T6355 12019-12021 IN denotes of
T6356 12022-12025 DT denotes the
T6357 12026-12031 JJ denotes above
T6358 12032-12036 NN denotes cell
T6359 12037-12042 NN denotes lines
T6360 12043-12046 VB denotes was
T6361 12047-12050 JJ denotes due
T6362 12051-12053 TO denotes to
T6363 12054-12061 JJ denotes genetic
T6364 12062-12073 NN denotes aberrations
T6365 12075-12082 RB denotes However
T6366 12082-12083 -COMMA- denotes ,
T6367 12084-12085 CD denotes 2
T6368 12086-12088 NN denotes bp
T6369 12089-12096 NN denotes changes
T6370 12097-12098 -LRB- denotes (
T6371 12098-12108 NN denotes nucleotide
T6372 12109-12114 NN denotes −1081
T6373 12114-12115 -COMMA- denotes ,
T6374 12116-12119 NN denotes T→C
T6375 12120-12123 CC denotes and
T6376 12124-12129 CD denotes −1068
T6377 12129-12130 -COMMA- denotes ,
T6378 12131-12134 NN denotes A→C
T6379 12134-12135 -RRB- denotes )
T6380 12136-12141 MD denotes could
T6381 12142-12144 VB denotes be
T6382 12145-12153 VB denotes detected
T6383 12154-12156 IN denotes in
T6384 12157-12161 CC denotes both
T6385 12162-12165 DT denotes the
T6386 12166-12180 JJ denotes IRF-4-positive
T6387 12181-12187 NN denotes BV-173
T6388 12188-12191 CC denotes and
T6389 12192-12195 DT denotes the
T6390 12196-12210 JJ denotes IRF-4-negative
T6391 12211-12218 NN denotes LAMA-84
T6392 12218-12219 -COMMA- denotes ,
T6393 12220-12224 NN denotes EM-2
T6394 12225-12228 CC denotes and
T6395 12229-12234 NN denotes K-562
T6396 12235-12236 -LRB- denotes (
T6397 12236-12242 NN denotes Figure
T6398 12243-12245 NN denotes 1B
T6399 12245-12246 -RRB- denotes )
T6400 12248-12250 IN denotes At
T6401 12251-12259 NN denotes position
T6402 12260-12264 CD denotes −116
T6403 12265-12267 DT denotes an
T6404 12268-12271 NN denotes A→C
T6405 12272-12284 NN denotes substitution
T6406 12285-12288 VB denotes was
T6407 12289-12294 VB denotes found
T6408 12295-12297 IN denotes in
T6409 12298-12302 NN denotes EM-2
T6410 12302-12303 -COMMA- denotes ,
T6411 12304-12309 NN denotes K-562
T6412 12310-12313 CC denotes and
T6413 12314-12320 NN denotes CML-T1
T6414 12320-12321 -COMMA- denotes ,
T6415 12322-12329 IN denotes whereas
T6416 12330-12336 NN denotes Jurkat
T6417 12336-12337 -COMMA- denotes ,
T6418 12338-12344 NN denotes BV-173
T6419 12345-12348 CC denotes and
T6420 12349-12353 NN denotes SD-1
T6421 12354-12363 VB denotes exhibited
T6422 12364-12365 DT denotes a
T6423 12366-12371 VB denotes mixed
T6424 12372-12375 NN denotes A/C
T6425 12376-12384 NN denotes sequence
T6426 12385-12388 CC denotes and
T6427 12389-12394 NN denotes U-937
T6428 12394-12395 -COMMA- denotes ,
T6429 12396-12403 NN denotes LAMA-84
T6430 12404-12407 CC denotes and
T6431 12408-12417 NN denotes RPMI-8226
T6432 12418-12420 DT denotes no
T6433 12421-12433 NN denotes substitution
T6434 12434-12436 IN denotes at
T6435 12437-12440 DT denotes all
T6436 12441-12442 -LRB- denotes (
T6437 12442-12448 NN denotes Figure
T6438 12449-12451 NN denotes 1B
T6439 12451-12452 -RRB- denotes )
T6440 12454-12466 RB denotes Consequently
T6441 12466-12467 -COMMA- denotes ,
T6442 12468-12473 DT denotes these
T6443 12474-12485 NN denotes alterations
T6444 12486-12489 VB denotes are
T6445 12490-12498 JJ denotes unlikely
T6446 12499-12501 TO denotes to
T6447 12502-12508 VB denotes affect
T6448 12509-12514 NN denotes IRF-4
T6449 12515-12525 NN denotes expression
T7025 12528-12536 NN denotes Increase
T7026 12537-12539 IN denotes of
T7027 12540-12545 NN denotes IRF-4
T7028 12546-12556 NN denotes expression
T7029 12557-12559 IN denotes in
T7030 12560-12573 JJ denotes hematopoietic
T7031 12574-12579 NN denotes cells
T7032 12580-12585 IN denotes after
T7033 12586-12599 VB denotes demethylating
T7034 12600-12609 NN denotes treatment
T7035 12610-12612 PRP denotes We
T7036 12613-12617 RB denotes next
T7037 12618-12626 VB denotes analyzed
T7038 12627-12634 IN denotes whether
T7039 12635-12643 NN denotes promoter
T7040 12644-12655 NN denotes methylation
T7041 12656-12661 MD denotes could
T7042 12662-12664 VB denotes be
T7043 12665-12676 JJ denotes responsible
T7044 12677-12680 IN denotes for
T7045 12681-12696 NN denotes down-regulation
T7046 12697-12699 IN denotes of
T7047 12700-12705 NN denotes IRF-4
T7048 12706-12716 NN denotes expression
T7049 12718-12719 DT denotes A
T7050 12720-12726 NN denotes region
T7051 12727-12736 VB denotes including
T7052 12737-12742 NN denotes exon1
T7053 12743-12745 IN denotes in
T7054 12746-12749 DT denotes the
T7055 12750-12755 NN denotes IRF-4
T7056 12756-12764 NN denotes promoter
T7057 12765-12774 VB denotes exhibited
T7058 12775-12776 DT denotes a
T7059 12777-12782 JJ denotes large
T7060 12783-12789 NN denotes number
T7061 12790-12792 IN denotes of
T7062 12793-12801 JJ denotes CpG-rich
T7063 12802-12811 NN denotes sequences
T7064 12812-12813 -LRB- denotes (
T7065 12813-12819 NN denotes Figure
T7066 12820-12822 NN denotes 3A
T7067 12822-12823 -RRB- denotes )
T7068 12825-12832 JJ denotes Several
T7069 12833-12841 JJ denotes chemical
T7070 12842-12852 NN denotes substances
T7071 12853-12857 JJ denotes such
T7072 12858-12860 IN denotes as
T7073 12861-12882 NN denotes 5-aza-2-deoxycytidine
T7074 12883-12884 -LRB- denotes (
T7075 12884-12889 NN denotes AzadC
T7076 12889-12890 -RRB- denotes )
T7077 12891-12893 CC denotes or
T7078 12894-12907 NN denotes 5-azacytidine
T7079 12908-12909 -LRB- denotes (
T7080 12909-12913 NN denotes AzaC
T7081 12913-12914 -RRB- denotes )
T7082 12915-12922 VB denotes inhibit
T7083 12923-12925 FW denotes de
T7084 12926-12930 FW denotes novo
T7085 12931-12934 CC denotes and
T7086 12935-12946 NN denotes maintenance
T7087 12947-12958 NN denotes methylation
T7088 12958-12959 -COMMA- denotes ,
T7089 12960-12963 CC denotes and
T7090 12964-12968 RB denotes thus
T7091 12969-12972 MD denotes can
T7092 12973-12975 VB denotes be
T7093 12976-12980 VB denotes used
T7094 12981-12983 TO denotes to
T7095 12984-12991 VB denotes discern
T7096 12992-13000 NN denotes promoter
T7097 13001-13012 NN denotes methylation
T7098 13013-13014 -LRB- denotes (
T7099 13014-13019 CD denotes 32,33
T7100 13019-13020 -RRB- denotes )
T7101 13022-13024 PRP denotes We
T7102 13025-13029 VB denotes used
T7103 13030-13035 NN denotes AzadC
T7104 13036-13038 TO denotes to
T7105 13039-13047 VB denotes generate
T7106 13048-13060 JJ denotes unmethylated
T7107 13061-13064 NN denotes DNA
T7108 13066-13067 DT denotes A
T7109 13068-13070 CD denotes 72
T7110 13071-13072 NN denotes h
T7111 13073-13088 NN denotes AzadC-treatment
T7112 13089-13097 VB denotes resulted
T7113 13098-13100 IN denotes in
T7114 13101-13102 DT denotes a
T7115 13103-13126 JJ denotes concentration-dependent
T7116 13127-13137 NN denotes activation
T7117 13138-13140 IN denotes of
T7118 13141-13146 NN denotes IRF-4
T7119 13147-13160 NN denotes transcription
T7120 13161-13163 IN denotes in
T7121 13164-13170 NN denotes Jurkat
T7122 13171-13174 CC denotes and
T7123 13175-13181 NN denotes CML-T1
T7124 13182-13189 NN denotes T-cells
T7125 13190-13192 RB denotes as
T7126 13193-13197 RB denotes well
T7127 13198-13200 IN denotes as
T7128 13201-13203 IN denotes in
T7129 13204-13209 NN denotes U-937
T7130 13209-13210 -COMMA- denotes ,
T7131 13211-13216 NN denotes K-562
T7132 13217-13220 CC denotes and
T7133 13221-13225 NN denotes EM-2
T7134 13226-13230 NN denotes cell
T7135 13231-13236 NN denotes lines
T7136 13237-13238 -LRB- denotes (
T7137 13238-13244 NN denotes Figure
T7138 13245-13247 NN denotes 2A
T7139 13247-13248 -RRB- denotes )
T7140 13250-13255 NN denotes IRF-4
T7141 13256-13269 NN denotes transcription
T7142 13270-13273 VB denotes was
T7143 13274-13281 VB denotes induced
T7144 13282-13284 IN denotes in
T7145 13285-13286 DT denotes a
T7146 13287-13301 JJ denotes time-dependent
T7147 13302-13308 NN denotes manner
T7148 13309-13312 CC denotes and
T7149 13313-13316 VB denotes was
T7150 13317-13325 VB denotes observed
T7151 13326-13328 RB denotes as
T7152 13329-13334 RB denotes early
T7153 13335-13337 IN denotes as
T7154 13338-13340 CD denotes 24
T7155 13341-13342 NN denotes h
T7156 13343-13348 IN denotes after
T7157 13349-13358 NN denotes treatment
T7158 13359-13363 IN denotes with
T7159 13364-13369 NN denotes AzadC
T7160 13370-13373 CC denotes and
T7161 13374-13383 VB denotes increased
T7162 13384-13388 IN denotes over
T7163 13389-13393 NN denotes time
T7164 13394-13399 IN denotes until
T7165 13400-13402 CD denotes 72
T7166 13403-13404 NN denotes h
T7167 13405-13406 -LRB- denotes (
T7168 13406-13412 NN denotes Figure
T7169 13413-13415 NN denotes 2B
T7170 13415-13416 -RRB- denotes )
T7171 13418-13422 NN denotes Time
T7172 13423-13426 CC denotes and
T7173 13427-13435 NN denotes strength
T7174 13436-13438 IN denotes of
T7175 13439-13442 DT denotes the
T7176 13443-13453 NN denotes appearance
T7177 13454-13456 IN denotes of
T7178 13457-13462 NN denotes IRF-4
T7179 13463-13474 NN denotes transcripts
T7180 13475-13481 VB denotes varied
T7181 13482-13487 IN denotes among
T7182 13488-13492 NN denotes cell
T7183 13493-13498 NN denotes lines
T7184 13498-13499 -COMMA- denotes ,
T7185 13500-13504 FW denotes i.e.
T7186 13505-13511 NN denotes CML-T1
T7187 13512-13521 VB denotes responded
T7188 13522-13531 JJ denotes strongest
T7189 13532-13534 TO denotes to
T7190 13535-13550 NN denotes AzadC-treatment
T7191 13551-13552 -LRB- denotes (
T7192 13552-13556 NN denotes data
T7193 13557-13560 RB denotes not
T7194 13561-13566 VB denotes shown
T7195 13566-13567 -RRB- denotes )
T7196 13569-13571 IN denotes In
T7197 13572-13576 NN denotes line
T7198 13577-13581 IN denotes with
T7199 13582-13586 DT denotes this
T7200 13586-13587 -COMMA- denotes ,
T7201 13588-13603 NN denotes AzadC-treatment
T7202 13604-13606 IN denotes of
T7203 13607-13613 NN denotes CML-T1
T7204 13614-13617 CC denotes and
T7205 13618-13625 NN denotes LAMA-84
T7206 13626-13631 NN denotes cells
T7207 13632-13636 RB denotes also
T7208 13637-13647 VB denotes translated
T7209 13648-13650 IN denotes in
T7210 13651-13653 DT denotes an
T7211 13654-13663 NN denotes induction
T7212 13664-13666 IN denotes of
T7213 13667-13672 NN denotes IRF-4
T7214 13673-13680 NN denotes protein
T7215 13681-13691 NN denotes expression
T7216 13692-13693 -LRB- denotes (
T7217 13693-13699 NN denotes Figure
T7218 13700-13702 NN denotes 2C
T7219 13702-13703 -RRB- denotes )
T7220 13705-13716 RB denotes Accordingly
T7221 13716-13717 -COMMA- denotes ,
T7222 13718-13727 NN denotes treatment
T7223 13728-13730 IN denotes of
T7224 13731-13734 DT denotes the
T7225 13735-13749 JJ denotes IRF-4-positive
T7226 13750-13754 NN denotes cell
T7227 13755-13759 NN denotes line
T7228 13760-13766 NN denotes BV-173
T7229 13766-13767 -COMMA- denotes ,
T7230 13768-13772 NN denotes SD-1
T7231 13773-13776 CC denotes and
T7232 13777-13786 NN denotes RPMI-8226
T7233 13787-13791 IN denotes with
T7234 13792-13797 NN denotes AzadC
T7235 13798-13801 VB denotes had
T7236 13802-13804 DT denotes no
T7237 13805-13811 NN denotes effect
T7238 13812-13814 IN denotes on
T7239 13815-13820 NN denotes IRF-4
T7240 13821-13831 NN denotes expression
T7241 13832-13833 -LRB- denotes (
T7242 13833-13839 NN denotes Figure
T7243 13840-13842 NN denotes 2D
T7244 13842-13843 -RRB- denotes )
T7245 13845-13850 EX denotes There
T7246 13851-13854 VB denotes was
T7247 13855-13857 DT denotes no
T7248 13858-13868 NN denotes difference
T7249 13869-13871 IN denotes in
T7250 13872-13875 DT denotes the
T7251 13876-13883 NN denotes effects
T7252 13884-13886 IN denotes of
T7253 13887-13891 NN denotes AzaC
T7254 13892-13898 IN denotes versus
T7255 13899-13904 NN denotes AzadC
T7256 13904-13905 -COMMA- denotes ,
T7257 13906-13908 IN denotes as
T7258 13909-13913 DT denotes both
T7259 13914-13923 VB denotes increased
T7260 13924-13927 DT denotes the
T7261 13928-13933 NN denotes IRF-4
T7262 13934-13938 NN denotes mRNA
T7263 13939-13944 NN denotes level
T7264 13945-13947 IN denotes in
T7265 13948-13954 NN denotes CML-T1
T7266 13955-13960 NN denotes cells
T7267 13961-13963 RB denotes as
T7268 13964-13968 RB denotes well
T7269 13969-13970 -LRB- denotes (
T7270 13970-13974 NN denotes data
T7271 13975-13978 RB denotes not
T7272 13979-13984 VB denotes shown
T7273 13984-13985 -RRB- denotes )
T7274 13987-13991 DT denotes This
T7275 13992-13999 VB denotes implied
T7276 14000-14004 IN denotes that
T7277 14005-14013 NN denotes promoter
T7278 14014-14025 NN denotes methylation
T7279 14026-14029 MD denotes may
T7280 14030-14037 VB denotes control
T7281 14038-14043 NN denotes IRF-4
T7282 14044-14054 NN denotes expression
T7283 14054-14055 -COMMA- denotes ,
T7284 14056-14059 CC denotes but
T7285 14060-14062 DT denotes an
T7286 14063-14074 JJ denotes alternative
T7287 14075-14086 NN denotes explanation
T7288 14087-14090 MD denotes may
T7289 14091-14093 VB denotes be
T7290 14094-14104 NN denotes activation
T7291 14105-14107 IN denotes of
T7292 14108-14116 JJ denotes positive
T7293 14117-14132 JJ denotes transcriptional
T7294 14133-14143 NN denotes regulators
T7295 14144-14146 IN denotes of
T7296 14147-14152 NN denotes IRF-4
T7297 14153-14155 IN denotes by
T7298 14156-14161 NN denotes AzadC
T7299 14162-14163 -LRB- denotes (
T7300 14163-14165 CC denotes or
T7301 14166-14170 NN denotes AzaC
T7302 14170-14171 -RRB- denotes )
T7852 14174-14195 JJ denotes Methylation-sensitive
T7853 14196-14203 NN denotes enzymes
T7854 14204-14206 VB denotes do
T7855 14207-14210 RB denotes not
T7856 14211-14214 VB denotes cut
T7857 14215-14223 JJ denotes specific
T7858 14224-14229 NN denotes sites
T7859 14230-14232 IN denotes in
T7860 14233-14236 DT denotes the
T7861 14237-14242 NN denotes IRF-4
T7862 14243-14251 NN denotes promoter
T7863 14252-14254 IN denotes in
T7864 14255-14268 JJ denotes hematopoietic
T7865 14269-14274 NN denotes cells
T7866 14275-14277 TO denotes To
T7867 14278-14285 RB denotes further
T7868 14286-14297 VB denotes investigate
T7869 14298-14306 NN denotes promoter
T7870 14307-14318 NN denotes methylation
T7871 14319-14321 IN denotes as
T7872 14322-14323 DT denotes a
T7873 14324-14334 JJ denotes regulatory
T7874 14335-14344 NN denotes mechanism
T7875 14345-14347 IN denotes of
T7876 14348-14353 NN denotes IRF-4
T7877 14354-14358 NN denotes gene
T7878 14359-14369 NN denotes expression
T7879 14369-14370 -COMMA- denotes ,
T7880 14371-14393 NN denotes restriction-PCR-assays
T7881 14394-14398 VB denotes were
T7882 14399-14408 VB denotes performed
T7883 14409-14410 -LRB- denotes (
T7884 14410-14415 CD denotes 20,24
T7885 14415-14416 -RRB- denotes )
T7886 14416-14417 -COMMA- denotes ,
T7887 14418-14423 WRB denotes where
T7888 14424-14428 RB denotes only
T7889 14429-14439 VB denotes methylated
T7890 14440-14443 NN denotes DNA
T7891 14444-14449 MD denotes would
T7892 14450-14453 RB denotes not
T7893 14454-14456 VB denotes be
T7894 14457-14460 VB denotes cut
T7895 14461-14469 VB denotes enabling
T7896 14470-14480 JJ denotes subsequent
T7897 14481-14484 NN denotes PCR
T7898 14485-14498 NN denotes amplification
T7899 14499-14502 CC denotes and
T7900 14503-14507 NN denotes vice
T7901 14508-14513 NN denotes versa
T7902 14515-14522 JJ denotes Genomic
T7903 14523-14526 NN denotes DNA
T7904 14527-14531 IN denotes from
T7905 14532-14540 JJ denotes leukemic
T7906 14541-14546 NN denotes cells
T7907 14547-14553 NN denotes Jurkat
T7908 14553-14554 -COMMA- denotes ,
T7909 14555-14561 NN denotes CML-T1
T7910 14561-14562 -COMMA- denotes ,
T7911 14563-14568 NN denotes U-937
T7912 14568-14569 -COMMA- denotes ,
T7913 14570-14575 NN denotes K-562
T7914 14575-14576 -COMMA- denotes ,
T7915 14577-14581 NN denotes EM-2
T7916 14582-14585 CC denotes and
T7917 14586-14592 NN denotes BV-173
T7918 14593-14596 VB denotes was
T7919 14597-14605 VB denotes digested
T7920 14606-14610 IN denotes with
T7921 14611-14614 DT denotes the
T7922 14615-14636 JJ denotes methylation-sensitive
T7923 14637-14644 NN denotes enzymes
T7924 14645-14650 NN denotes HpaII
T7925 14650-14651 -COMMA- denotes ,
T7926 14652-14660 NN denotes Bsh1236I
T7927 14661-14664 CC denotes and
T7928 14665-14682 NN denotes HaeII-isochizomer
T7929 14683-14691 NN denotes Bsp143II
T7930 14693-14698 NNP denotes EcoRI
T7931 14698-14699 -COMMA- denotes ,
T7932 14700-14705 WDT denotes which
T7933 14706-14709 VB denotes has
T7934 14710-14712 DT denotes no
T7935 14713-14724 NN denotes recognition
T7936 14725-14729 NN denotes site
T7937 14730-14736 IN denotes within
T7938 14737-14740 DT denotes the
T7939 14741-14746 NN denotes IRF-4
T7940 14747-14755 NN denotes promoter
T7941 14755-14756 -COMMA- denotes ,
T7942 14757-14760 CC denotes and
T7943 14761-14764 DT denotes the
T7944 14765-14786 JJ denotes methylation-resistant
T7945 14787-14793 NN denotes enzyme
T7946 14794-14798 NN denotes MspI
T7947 14799-14805 VB denotes served
T7948 14806-14808 IN denotes as
T7949 14809-14817 NN denotes controls
T7950 14819-14822 CD denotes Two
T7951 14823-14831 JJ denotes separate
T7952 14832-14845 NN denotes amplification
T7953 14846-14855 NN denotes reactions
T7954 14856-14860 VB denotes were
T7955 14861-14870 VB denotes performed
T7956 14870-14871 -COMMA- denotes ,
T7957 14872-14882 VB denotes generating
T7958 14883-14886 CD denotes two
T7959 14887-14896 NN denotes fragments
T7960 14896-14897 -COMMA- denotes ,
T7961 14898-14900 NN denotes F1
T7962 14901-14904 CC denotes and
T7963 14905-14907 NN denotes F2
T7964 14908-14909 -LRB- denotes (
T7965 14909-14915 NN denotes Figure
T7966 14916-14918 NN denotes 3A
T7967 14918-14919 -RRB- denotes )
T7968 14921-14926 IN denotes After
T7969 14927-14936 NN denotes digestion
T7970 14937-14941 IN denotes with
T7971 14942-14947 NN denotes HpaII
T7972 14948-14951 CC denotes and
T7973 14952-14960 NN denotes Bsp143II
T7974 14961-14962 DT denotes a
T7975 14963-14973 JJ denotes sufficient
T7976 14974-14977 NN denotes PCR
T7977 14978-14991 NN denotes amplification
T7978 14992-14994 IN denotes of
T7979 14995-14997 NN denotes F1
T7980 14998-15001 CC denotes and
T7981 15002-15004 NN denotes F2
T7982 15005-15008 VB denotes was
T7983 15009-15017 VB denotes detected
T7984 15018-15020 IN denotes in
T7985 15021-15024 NN denotes DNA
T7986 15025-15029 IN denotes from
T7987 15030-15044 JJ denotes IRF-4-negative
T7988 15045-15051 NN denotes Jurkat
T7989 15051-15052 -COMMA- denotes ,
T7990 15053-15059 NN denotes CML-T1
T7991 15059-15060 -COMMA- denotes ,
T7992 15061-15066 NN denotes U-937
T7993 15066-15067 -COMMA- denotes ,
T7994 15068-15073 NN denotes K-562
T7995 15074-15077 CC denotes and
T7996 15078-15082 NN denotes EM-2
T7997 15083-15088 NN denotes cells
T7998 15088-15089 -COMMA- denotes ,
T7999 15090-15100 VB denotes suggesting
T8000 15101-15102 DT denotes a
T8001 15103-15111 NN denotes promoter
T8002 15112-15123 NN denotes methylation
T8003 15124-15125 -LRB- denotes (
T8004 15125-15128 CC denotes and
T8005 15129-15140 NN denotes restriction
T8006 15141-15151 NN denotes protection
T8007 15151-15152 -RRB- denotes )
T8008 15153-15155 IN denotes at
T8009 15156-15159 DT denotes the
T8010 15160-15170 JJ denotes respective
T8011 15171-15182 NN denotes recognition
T8012 15183-15188 NN denotes sites
T8013 15189-15190 -LRB- denotes (
T8014 15190-15196 NN denotes Figure
T8015 15197-15199 NN denotes 3B
T8016 15200-15203 CC denotes and
T8017 15204-15205 NN denotes C
T8018 15205-15206 -RRB- denotes )
T8019 15208-15215 RB denotes Notably
T8020 15215-15216 -COMMA- denotes ,
T8021 15217-15219 IN denotes in
T8022 15220-15234 JJ denotes IRF-4-positive
T8023 15235-15239 NN denotes SD-1
T8024 15240-15245 NN denotes cells
T8025 15246-15255 NN denotes digestion
T8026 15256-15260 IN denotes with
T8027 15261-15264 DT denotes the
T8028 15265-15286 JJ denotes methylation-sensitive
T8029 15287-15294 NN denotes enzymes
T8030 15295-15305 RB denotes completely
T8031 15306-15315 VB denotes inhibited
T8032 15316-15329 NN denotes amplification
T8033 15330-15332 IN denotes of
T8034 15333-15335 NN denotes F1
T8035 15336-15339 CC denotes and
T8036 15340-15342 NN denotes F2
T8037 15344-15346 IN denotes In
T8038 15347-15361 JJ denotes IRF-4-positive
T8039 15362-15368 NN denotes BV-173
T8040 15369-15374 NN denotes cells
T8041 15375-15376 DT denotes a
T8042 15377-15382 NN denotes HpaII
T8043 15382-15383 -COMMA- denotes ,
T8044 15384-15387 CC denotes but
T8045 15388-15391 RB denotes not
T8046 15392-15393 DT denotes a
T8047 15394-15402 NN denotes Bsh1236I
T8048 15403-15412 NN denotes digestion
T8049 15412-15413 -COMMA- denotes ,
T8050 15414-15427 RB denotes significantly
T8051 15428-15435 VB denotes reduced
T8052 15436-15439 DT denotes the
T8053 15440-15451 JJ denotes amplifiable
T8054 15452-15455 NN denotes DNA
T8055 15456-15463 NN denotes message
T8056 15464-15466 IN denotes of
T8057 15467-15469 NN denotes F2
T8058 15470-15471 -LRB- denotes (
T8059 15471-15477 NN denotes Figure
T8060 15478-15480 NN denotes 3C
T8061 15480-15481 -RRB- denotes )
T8062 15481-15482 -COMMA- denotes ,
T8063 15483-15490 IN denotes whereas
T8064 15491-15504 NN denotes amplification
T8065 15505-15507 IN denotes of
T8066 15508-15510 NN denotes F1
T8067 15511-15514 VB denotes was
T8068 15515-15518 RB denotes not
T8069 15519-15527 VB denotes affected
T8070 15528-15529 -LRB- denotes (
T8071 15529-15535 NN denotes Figure
T8072 15536-15538 NN denotes 3B
T8073 15538-15539 -RRB- denotes )
T8074 15541-15545 DT denotes This
T8075 15546-15553 VB denotes implied
T8076 15554-15558 IN denotes that
T8077 15559-15564 NN denotes IRF-4
T8078 15565-15578 NN denotes transcription
T8079 15579-15581 IN denotes in
T8080 15582-15586 NN denotes SD-1
T8081 15587-15590 CC denotes and
T8082 15591-15597 NN denotes BV-173
T8083 15598-15603 NN denotes cells
T8084 15604-15606 VB denotes is
T8085 15607-15617 VB denotes associated
T8086 15618-15622 IN denotes with
T8087 15623-15627 JJ denotes less
T8088 15628-15636 NN denotes promoter
T8089 15637-15648 NN denotes methylation
T8090 15649-15650 -LRB- denotes (
T8091 15650-15652 IN denotes in
T8092 15653-15659 NN denotes BV-173
T8093 15660-15670 RB denotes especially
T8094 15671-15673 IN denotes at
T8095 15674-15679 NN denotes HpaII
T8096 15680-15685 NN denotes sites
T8097 15685-15686 -RRB- denotes )
T8098 15687-15689 IN denotes as
T8099 15690-15698 VB denotes compared
T8100 15699-15703 IN denotes with
T8101 15704-15707 DT denotes the
T8102 15708-15714 VB denotes tested
T8103 15715-15729 JJ denotes IRF-4-negative
T8104 15730-15735 NN denotes cells
T8578 15738-15746 JJ denotes Specific
T8579 15747-15750 NN denotes CpG
T8580 15751-15756 NN denotes sites
T8581 15757-15759 IN denotes in
T8582 15760-15763 DT denotes the
T8583 15764-15769 NN denotes IRF-4
T8584 15770-15778 NN denotes promoter
T8585 15779-15782 VB denotes are
T8586 15783-15793 VB denotes methylated
T8587 15794-15796 IN denotes in
T8588 15797-15810 JJ denotes hematopoietic
T8589 15811-15816 NN denotes cells
T8590 15817-15819 IN denotes In
T8591 15820-15825 NN denotes order
T8592 15826-15828 TO denotes to
T8593 15829-15836 RB denotes exactly
T8594 15837-15840 VB denotes map
T8595 15841-15844 DT denotes the
T8596 15845-15856 NN denotes methylation
T8597 15857-15862 NN denotes sites
T8598 15863-15869 IN denotes within
T8599 15870-15873 DT denotes the
T8600 15874-15879 NN denotes IRF-4
T8601 15880-15888 NN denotes promoter
T8602 15888-15889 -COMMA- denotes ,
T8603 15890-15892 PRP denotes we
T8604 15893-15900 VB denotes treated
T8605 15901-15904 NN denotes DNA
T8606 15905-15907 IN denotes of
T8607 15908-15914 NN denotes Jurkat
T8608 15914-15915 -COMMA- denotes ,
T8609 15916-15922 NN denotes CML-T1
T8610 15922-15923 -COMMA- denotes ,
T8611 15924-15929 NN denotes U-937
T8612 15929-15930 -COMMA- denotes ,
T8613 15931-15936 NN denotes K-562
T8614 15937-15940 CC denotes and
T8615 15941-15945 NN denotes EM-2
T8616 15946-15951 NN denotes cells
T8617 15952-15954 RB denotes as
T8618 15955-15959 RB denotes well
T8619 15960-15962 IN denotes as
T8620 15963-15965 IN denotes of
T8621 15966-15970 NN denotes SD-1
T8622 15970-15971 -COMMA- denotes ,
T8623 15972-15981 NN denotes RPMI-8226
T8624 15982-15985 CC denotes and
T8625 15986-15992 NN denotes BV-173
T8626 15993-16000 NN denotes control
T8627 16001-16006 NN denotes cells
T8628 16007-16011 IN denotes with
T8629 16012-16021 NN denotes bisulfite
T8630 16021-16022 -COMMA- denotes ,
T8631 16023-16028 WDT denotes which
T8632 16029-16039 RB denotes chemically
T8633 16040-16048 VB denotes converts
T8634 16049-16061 JJ denotes unmethylated
T8635 16062-16070 NN denotes cytosine
T8636 16071-16073 TO denotes to
T8637 16074-16080 NN denotes uracil
T8638 16080-16081 -COMMA- denotes ,
T8639 16082-16089 IN denotes whereas
T8640 16090-16092 PRP denotes it
T8641 16093-16096 VB denotes has
T8642 16097-16099 DT denotes no
T8643 16100-16106 NN denotes effect
T8644 16107-16109 IN denotes on
T8645 16110-16120 VB denotes methylated
T8646 16121-16129 NN denotes cytosine
T8647 16129-16130 -COMMA- denotes ,
T8648 16131-16135 FW denotes i.e.
T8649 16136-16138 IN denotes in
T8650 16139-16142 NN denotes CpG
T8651 16143-16144 -LRB- denotes (
T8652 16144-16146 CD denotes 34
T8653 16146-16147 -RRB- denotes )
T8654 16149-16153 DT denotes This
T8655 16154-16163 NN denotes technique
T8656 16164-16166 VB denotes is
T8657 16167-16177 RB denotes especially
T8658 16178-16184 JJ denotes useful
T8659 16185-16188 IN denotes for
T8660 16189-16198 NN denotes detection
T8661 16199-16201 IN denotes of
T8662 16202-16209 JJ denotes unknown
T8663 16210-16221 NN denotes methylation
T8664 16222-16230 NN denotes patterns
T8665 16232-16235 NN denotes PCR
T8666 16236-16249 NN denotes amplification
T8667 16249-16250 -COMMA- denotes ,
T8668 16251-16258 NN denotes cloning
T8669 16259-16262 CC denotes and
T8670 16263-16273 NN denotes sequencing
T8671 16274-16276 IN denotes of
T8672 16277-16280 DT denotes the
T8673 16281-16298 JJ denotes bisulfite-treated
T8674 16299-16302 NN denotes DNA
T8675 16303-16309 VB denotes showed
T8676 16310-16311 DT denotes a
T8677 16312-16320 JJ denotes specific
T8678 16321-16332 NN denotes methylation
T8679 16333-16340 NN denotes pattern
T8680 16341-16343 IN denotes of
T8681 16344-16347 DT denotes the
T8682 16348-16356 VB denotes analyzed
T8683 16357-16359 CD denotes 62
T8684 16360-16363 NN denotes CpG
T8685 16364-16369 NN denotes sites
T8686 16370-16372 IN denotes in
T8687 16373-16376 DT denotes all
T8688 16377-16381 NN denotes cell
T8689 16382-16387 NN denotes lines
T8690 16388-16389 -LRB- denotes (
T8691 16389-16395 NN denotes Figure
T8692 16396-16397 CD denotes 4
T8693 16398-16401 CC denotes and
T8694 16402-16407 NN denotes Table
T8695 16408-16409 CD denotes 1
T8696 16409-16410 -RRB- denotes )
T8697 16412-16414 IN denotes In
T8698 16415-16422 JJ denotes general
T8699 16422-16423 -COMMA- denotes ,
T8700 16424-16427 DT denotes the
T8701 16428-16441 JJ denotes methylational
T8702 16442-16448 NN denotes status
T8703 16449-16455 VB denotes ranged
T8704 16456-16460 IN denotes from
T8705 16461-16464 CD denotes one
T8706 16465-16469 NN denotes cell
T8707 16470-16474 NN denotes line
T8708 16475-16479 IN denotes with
T8709 16480-16481 DT denotes a
T8710 16482-16488 RB denotes nearly
T8711 16489-16503 JJ denotes non-methylated
T8712 16504-16509 NN denotes IRF-4
T8713 16510-16518 NN denotes promoter
T8714 16519-16520 -LRB- denotes (
T8715 16520-16524 NN denotes SD-1
T8716 16524-16525 -COMMA- denotes ,
T8717 16526-16540 JJ denotes IRF-4-positive
T8718 16540-16541 -RRB- denotes )
T8719 16542-16544 TO denotes to
T8720 16545-16546 DT denotes a
T8721 16547-16557 RB denotes completely
T8722 16558-16568 VB denotes methylated
T8723 16569-16574 NN denotes IRF-4
T8724 16575-16583 NN denotes promoter
T8725 16584-16586 IN denotes in
T8726 16587-16593 NN denotes CML-T1
T8727 16594-16595 -LRB- denotes (
T8728 16595-16609 JJ denotes IRF-4-negative
T8729 16609-16610 -RRB- denotes )
T8730 16612-16625 RB denotes Interestingly
T8731 16625-16626 -COMMA- denotes ,
T8732 16627-16630 DT denotes the
T8733 16631-16641 NN denotes percentage
T8734 16642-16644 IN denotes of
T8735 16645-16648 NN denotes CpG
T8736 16649-16660 NN denotes methylation
T8737 16661-16663 IN denotes in
T8738 16664-16667 DT denotes the
T8739 16668-16673 NN denotes IRF-4
T8740 16674-16682 NN denotes promoter
T8741 16683-16687 IN denotes from
T8742 16688-16702 JJ denotes IRF-4-positive
T8743 16703-16708 NN denotes cells
T8744 16709-16712 VB denotes was
T8745 16713-16717 RB denotes very
T8746 16718-16721 JJ denotes low
T8747 16722-16723 -LRB- denotes (
T8748 16723-16727 NN denotes mean
T8749 16728-16730 CD denotes 24
T8750 16730-16731 NN denotes %
T8751 16731-16732 -RRB- denotes )
T8752 16733-16735 IN denotes as
T8753 16736-16744 VB denotes compared
T8754 16745-16749 IN denotes with
T8755 16750-16764 JJ denotes IRF-4-negative
T8756 16765-16770 NN denotes cells
T8757 16771-16772 -LRB- denotes (
T8758 16772-16776 NN denotes mean
T8759 16777-16779 CD denotes 94
T8760 16779-16780 NN denotes %
T8761 16780-16781 -RRB- denotes )
T8762 16782-16783 -LRB- denotes (
T8763 16783-16789 NN denotes Figure
T8764 16790-16792 NN denotes 4A
T8765 16793-16796 CC denotes and
T8766 16797-16802 JJ denotes Table
T8767 16803-16804 CD denotes 1
T8768 16804-16805 -RRB- denotes )
T8769 16807-16808 DT denotes A
T8770 16809-16818 NN denotes 5′-region
T8771 16819-16820 -LRB- denotes (
T8772 16820-16822 NN denotes R1
T8773 16822-16823 -RRB- denotes )
T8774 16824-16828 IN denotes with
T8775 16829-16831 CD denotes 13
T8776 16832-16847 VB denotes hypermethylated
T8777 16848-16851 NN denotes CpG
T8778 16852-16857 NN denotes sites
T8779 16858-16859 -LRB- denotes (
T8780 16859-16863 JJ denotes mean
T8781 16864-16870 NN denotes number
T8782 16871-16873 IN denotes of
T8783 16874-16884 VB denotes methylated
T8784 16885-16891 NN denotes clones
T8785 16892-16895 CD denotes 5.5
T8786 16896-16898 IN denotes of
T8787 16899-16900 CD denotes 8
T8788 16901-16905 IN denotes with
T8789 16906-16908 CD denotes 77
T8790 16908-16909 NN denotes %
T8791 16910-16920 VB denotes methylated
T8792 16921-16925 NN denotes CpGs
T8793 16925-16926 -RRB- denotes )
T8794 16927-16930 VB denotes was
T8795 16931-16936 VB denotes found
T8796 16937-16939 IN denotes in
T8797 16940-16944 JJ denotes most
T8798 16945-16950 NN denotes cells
T8799 16951-16952 -LRB- denotes (
T8800 16952-16958 IN denotes except
T8801 16959-16963 NN denotes SD-1
T8802 16964-16967 CC denotes and
T8803 16968-16977 NN denotes RPMI-8226
T8804 16977-16978 -RRB- denotes )
T8805 16979-16982 CC denotes and
T8806 16983-16984 DT denotes a
T8807 16985-16994 NN denotes 3′-region
T8808 16995-16996 -LRB- denotes (
T8809 16996-16998 NN denotes R3
T8810 16998-16999 -RRB- denotes )
T8811 17000-17002 IN denotes of
T8812 17003-17004 CD denotes 6
T8813 17005-17019 VB denotes hypomethylated
T8814 17020-17023 NN denotes CpG
T8815 17024-17029 NN denotes sites
T8816 17030-17031 -LRB- denotes (
T8817 17031-17035 JJ denotes mean
T8818 17036-17042 NN denotes number
T8819 17043-17045 IN denotes of
T8820 17046-17056 VB denotes methylated
T8821 17057-17063 NN denotes clones
T8822 17064-17067 CD denotes 1.7
T8823 17068-17070 IN denotes of
T8824 17071-17072 CD denotes 8
T8825 17073-17077 IN denotes with
T8826 17078-17080 CD denotes 33
T8827 17080-17081 NN denotes %
T8828 17082-17092 VB denotes methylated
T8829 17093-17097 NN denotes CpGs
T8830 17097-17098 -RRB- denotes )
T8831 17099-17102 VB denotes was
T8832 17103-17108 VB denotes found
T8833 17109-17111 IN denotes in
T8834 17112-17116 JJ denotes most
T8835 17117-17122 NN denotes cells
T8836 17123-17124 -LRB- denotes (
T8837 17124-17130 IN denotes except
T8838 17131-17137 NN denotes CML-T1
T8839 17138-17141 CC denotes and
T8840 17142-17147 NN denotes U-937
T8841 17147-17148 -RRB- denotes )
T8842 17149-17150 -LRB- denotes (
T8843 17150-17156 NN denotes Figure
T8844 17157-17159 NN denotes 4A
T8845 17160-17163 CC denotes and
T8846 17164-17169 JJ denotes Table
T8847 17170-17171 CD denotes 1
T8848 17171-17172 -RRB- denotes )
T8849 17174-17186 RB denotes Intriguingly
T8850 17186-17187 -COMMA- denotes ,
T8851 17188-17189 DT denotes a
T8852 17190-17197 NN denotes stretch
T8853 17198-17200 IN denotes of
T8854 17201-17203 CD denotes 13
T8855 17204-17207 NN denotes CpG
T8856 17208-17213 NN denotes sites
T8857 17214-17215 -LRB- denotes (
T8858 17215-17216 -SHARP- denotes #
T8859 17216-17221 CD denotes 10–22
T8860 17221-17222 -COLON- denotes ;
T8861 17223-17225 NN denotes R2
T8862 17225-17226 -RRB- denotes )
T8863 17227-17230 VB denotes was
T8864 17231-17239 VB denotes detected
T8865 17240-17242 IN denotes in
T8866 17243-17250 IN denotes between
T8867 17251-17256 DT denotes these
T8868 17257-17264 NN denotes regions
T8869 17264-17265 -COMMA- denotes ,
T8870 17266-17271 WDT denotes which
T8871 17272-17276 VB denotes were
T8872 17277-17283 RB denotes highly
T8873 17284-17294 VB denotes methylated
T8874 17295-17297 IN denotes in
T8875 17298-17312 JJ denotes IRF-4-negative
T8876 17313-17314 -LRB- denotes (
T8877 17314-17318 JJ denotes mean
T8878 17319-17325 NN denotes number
T8879 17326-17328 IN denotes of
T8880 17329-17339 VB denotes methylated
T8881 17340-17346 NN denotes clones
T8882 17347-17350 CD denotes 7.1
T8883 17351-17353 IN denotes of
T8884 17354-17355 CD denotes 8
T8885 17356-17360 IN denotes with
T8886 17361-17363 CD denotes 89
T8887 17363-17364 NN denotes %
T8888 17365-17375 VB denotes methylated
T8889 17376-17380 NN denotes CpGs
T8890 17380-17381 -RRB- denotes )
T8891 17382-17385 CC denotes but
T8892 17386-17393 RB denotes totally
T8893 17394-17408 JJ denotes non-methylated
T8894 17409-17411 IN denotes in
T8895 17412-17426 JJ denotes IRF-4-positive
T8896 17427-17432 NN denotes cells
T8897 17433-17434 -LRB- denotes (
T8898 17434-17440 NN denotes Figure
T8899 17441-17443 NN denotes 4A
T8900 17444-17447 CC denotes and
T8901 17448-17449 NN denotes B
T8902 17449-17450 -RRB- denotes )
T8903 17452-17463 RB denotes Furthermore
T8904 17463-17464 -COMMA- denotes ,
T8905 17465-17470 CD denotes three
T8906 17471-17474 NN denotes CpG
T8907 17475-17480 NN denotes sites
T8908 17481-17483 IN denotes at
T8909 17484-17487 DT denotes the
T8910 17488-17490 NN denotes 5′
T8911 17491-17494 NN denotes end
T8912 17495-17496 -LRB- denotes (
T8913 17496-17497 -SHARP- denotes #
T8914 17497-17499 CD denotes 54
T8915 17499-17500 -COMMA- denotes ,
T8916 17501-17503 CD denotes 56
T8917 17503-17504 -COMMA- denotes ,
T8918 17505-17507 CD denotes 58
T8919 17507-17508 -RRB- denotes )
T8920 17509-17512 CC denotes and
T8921 17513-17516 CD denotes two
T8922 17517-17520 NN denotes CpG
T8923 17521-17527 NN denotes motifs
T8924 17528-17530 IN denotes at
T8925 17531-17534 DT denotes the
T8926 17535-17537 NN denotes 3′
T8927 17538-17541 NN denotes end
T8928 17542-17543 -LRB- denotes (
T8929 17543-17544 -SHARP- denotes #
T8930 17544-17545 CD denotes 1
T8931 17545-17546 -COMMA- denotes ,
T8932 17547-17548 CD denotes 2
T8933 17548-17549 -RRB- denotes )
T8934 17550-17556 VB denotes showed
T8935 17557-17561 DT denotes this
T8936 17562-17568 JJ denotes direct
T8937 17569-17580 NN denotes correlation
T8938 17581-17588 IN denotes between
T8939 17589-17593 JJ denotes high
T8940 17594-17605 NN denotes methylation
T8941 17606-17612 NN denotes status
T8942 17613-17616 CC denotes and
T8943 17617-17624 NN denotes absence
T8944 17625-17627 IN denotes of
T8945 17628-17633 NN denotes IRF-4
T8946 17634-17644 NN denotes expression
T8947 17646-17648 IN denotes In
T8948 17649-17657 NN denotes addition
T8949 17657-17658 -COMMA- denotes ,
T8950 17659-17662 CD denotes two
T8951 17663-17666 NN denotes CpG
T8952 17667-17672 NN denotes sites
T8953 17673-17680 JJ denotes located
T8954 17681-17683 IN denotes in
T8955 17684-17685 DT denotes a
T8956 17686-17690 NN denotes NFκB
T8957 17691-17692 -LRB- denotes (
T8958 17692-17693 -SHARP- denotes #
T8959 17693-17695 CD denotes 48
T8960 17695-17696 -RRB- denotes )
T8961 17697-17700 CC denotes and
T8962 17701-17702 DT denotes a
T8963 17703-17706 NN denotes SP1
T8964 17707-17714 NN denotes element
T8965 17715-17716 -LRB- denotes (
T8966 17716-17717 -SHARP- denotes #
T8967 17717-17719 CD denotes 45
T8968 17719-17720 -RRB- denotes )
T8969 17721-17724 VB denotes are
T8970 17725-17729 RB denotes less
T8971 17730-17740 VB denotes methylated
T8972 17741-17743 IN denotes in
T8973 17744-17758 JJ denotes IRF-4-positive
T8974 17759-17763 IN denotes than
T8975 17764-17766 IN denotes in
T8976 17767-17781 JJ denotes IRF-4-negative
T8977 17782-17787 NN denotes cells
T8978 17788-17789 -LRB- denotes (
T8979 17789-17793 JJ denotes mean
T8980 17794-17800 NN denotes number
T8981 17801-17803 IN denotes of
T8982 17804-17814 VB denotes methylated
T8983 17815-17821 NN denotes clones
T8984 17821-17822 -COLON- denotes :
T8985 17823-17826 CD denotes 1/8
T8986 17827-17833 CC denotes versus
T8987 17834-17837 CD denotes 8/8
T8988 17837-17838 -RRB- denotes )
T8989 17840-17845 DT denotes These
T8990 17846-17853 NN denotes results
T8991 17854-17862 VB denotes indicate
T8992 17863-17866 DT denotes the
T8993 17867-17878 NN denotes involvement
T8994 17879-17881 IN denotes of
T8995 17882-17885 NN denotes CpG
T8996 17886-17897 NN denotes methylation
T8997 17898-17900 IN denotes in
T8998 17901-17904 DT denotes the
T8999 17905-17915 NN denotes regulation
T9000 17916-17918 IN denotes of
T9001 17919-17924 NN denotes IRF-4
T9002 17925-17935 NN denotes expression
T9003 17936-17938 IN denotes in
T9004 17939-17947 JJ denotes leukemic
T9005 17948-17953 NN denotes cells
T9706 17956-17958 FW denotes In
T9707 17959-17964 FW denotes vitro
T9708 17965-17976 NN denotes methylation
T9709 17977-17979 IN denotes of
T9710 17980-17982 DT denotes an
T9711 17983-17988 NN denotes IRF-4
T9712 17989-18006 JJ denotes promoter-reporter
T9713 18007-18016 NN denotes construct
T9714 18017-18026 VB denotes decreases
T9715 18027-18030 PRP-DOLLAR- denotes its
T9716 18031-18039 NN denotes activity
T9717 18040-18042 TO denotes To
T9718 18043-18050 VB denotes provide
T9719 18051-18059 NN denotes evidence
T9720 18060-18063 IN denotes for
T9721 18064-18065 DT denotes a
T9722 18066-18072 JJ denotes direct
T9723 18073-18079 NN denotes effect
T9724 18080-18082 IN denotes of
T9725 18083-18096 JJ denotes methylational
T9726 18097-18103 NN denotes status
T9727 18104-18106 IN denotes on
T9728 18107-18112 NN denotes IRF-4
T9729 18113-18121 NN denotes promoter
T9730 18122-18130 NN denotes activity
T9731 18131-18133 PRP denotes we
T9732 18134-18143 VB denotes performed
T9733 18144-18152 NN denotes reporter
T9734 18153-18157 NN denotes gene
T9735 18158-18164 NN denotes assays
T9736 18165-18169 IN denotes with
T9737 18170-18175 NN denotes IRF-4
T9738 18176-18184 NN denotes promoter
T9739 18185-18195 NN denotes constructs
T9740 18196-18202 IN denotes before
T9741 18203-18206 CC denotes and
T9742 18207-18212 IN denotes after
T9743 18213-18218 PRP-DOLLAR- denotes their
T9744 18219-18221 FW denotes in
T9745 18222-18227 FW denotes vitro
T9746 18228-18239 NN denotes methylation
T9747 18241-18242 DT denotes A
T9748 18243-18251 JJ denotes complete
T9749 18252-18263 NN denotes methylation
T9750 18264-18266 IN denotes of
T9751 18267-18272 DT denotes these
T9752 18273-18283 NN denotes constructs
T9753 18284-18287 VB denotes was
T9754 18288-18295 VB denotes checked
T9755 18296-18299 IN denotes via
T9756 18300-18311 NN denotes restriction
T9757 18312-18318 NN denotes assays
T9758 18319-18323 IN denotes with
T9759 18324-18345 JJ denotes methylation-sensitive
T9760 18346-18359 NN denotes endonucleases
T9761 18360-18361 -LRB- denotes (
T9762 18361-18367 NN denotes Figure
T9763 18368-18370 NN denotes 5A
T9764 18370-18371 -RRB- denotes )
T9765 18373-18385 RB denotes Intriguingly
T9766 18385-18386 -COMMA- denotes ,
T9767 18387-18398 NN denotes methylation
T9768 18399-18401 IN denotes of
T9769 18402-18405 DT denotes the
T9770 18406-18411 NN denotes IRF-4
T9771 18412-18420 NN denotes promoter
T9772 18421-18434 RB denotes significantly
T9773 18435-18444 VB denotes decreased
T9774 18445-18453 NN denotes promoter
T9775 18454-18462 NN denotes activity
T9776 18463-18465 IN denotes in
T9777 18466-18480 JJ denotes IRF-4-positive
T9778 18481-18485 NN denotes SD-1
T9779 18486-18491 NN denotes cells
T9780 18492-18494 IN denotes by
T9781 18495-18499 CD denotes 85.0
T9782 18499-18500 NN denotes %
T9783 18501-18502 -LRB- denotes (
T9784 18502-18508 NN denotes Figure
T9785 18509-18511 NN denotes 5B
T9786 18511-18512 -RRB- denotes )
T9787 18514-18517 DT denotes The
T9788 18518-18527 JJ denotes silencing
T9789 18528-18534 NN denotes effect
T9790 18535-18537 IN denotes of
T9791 18538-18541 NN denotes CpG
T9792 18542-18553 NN denotes methylation
T9793 18554-18557 VB denotes was
T9794 18558-18561 RB denotes not
T9795 18562-18572 JJ denotes restricted
T9796 18573-18575 TO denotes to
T9797 18576-18590 JJ denotes IRF-4-positive
T9798 18591-18596 NN denotes cells
T9799 18596-18597 -COMMA- denotes ,
T9800 18598-18603 IN denotes since
T9801 18604-18606 FW denotes in
T9802 18607-18612 FW denotes vitro
T9803 18613-18624 NN denotes methylation
T9804 18625-18628 VB denotes led
T9805 18629-18631 TO denotes to
T9806 18632-18633 DT denotes a
T9807 18634-18638 CD denotes 92.9
T9808 18638-18639 NN denotes %
T9809 18640-18650 NN denotes abrogation
T9810 18651-18653 IN denotes of
T9811 18654-18662 NN denotes promoter
T9812 18663-18671 NN denotes activity
T9813 18672-18674 IN denotes in
T9814 18675-18689 JJ denotes IRF-4-negative
T9815 18690-18696 NN denotes Jurkat
T9816 18697-18702 NN denotes cells
T9817 18703-18704 -LRB- denotes (
T9818 18704-18710 NN denotes Figure
T9819 18711-18713 NN denotes 5C
T9820 18713-18714 -RRB- denotes )
T9821 18716-18718 IN denotes In
T9822 18719-18727 NN denotes contrast
T9823 18727-18728 -COMMA- denotes ,
T9824 18729-18736 NN denotes control
T9825 18737-18748 NN denotes methylation
T9826 18749-18751 IN denotes of
T9827 18752-18753 DT denotes a
T9828 18754-18762 NN denotes reporter
T9829 18763-18772 NN denotes construct
T9830 18773-18777 IN denotes with
T9831 18778-18779 DT denotes a
T9832 18780-18789 JJ denotes different
T9833 18790-18798 NN denotes promoter
T9834 18799-18800 -LRB- denotes (
T9835 18800-18804 NN denotes FasL
T9836 18804-18805 -RRB- denotes )
T9837 18806-18808 RB denotes as
T9838 18809-18813 RB denotes well
T9839 18814-18816 IN denotes as
T9840 18817-18819 DT denotes an
T9841 18820-18825 JJ denotes empty
T9842 18826-18832 NN denotes vector
T9843 18833-18836 VB denotes had
T9844 18837-18839 DT denotes no
T9845 18840-18846 NN denotes effect
T9846 18847-18849 IN denotes on
T9847 18850-18853 DT denotes the
T9848 18854-18862 NN denotes reporter
T9849 18863-18871 NN denotes activity
T9850 18872-18873 -LRB- denotes (
T9851 18873-18877 NN denotes data
T9852 18878-18881 RB denotes not
T9853 18882-18887 VB denotes shown
T9854 18887-18888 -RRB- denotes )
T9855 18890-18895 DT denotes These
T9856 18896-18900 NN denotes data
T9857 18901-18907 VB denotes proved
T9858 18908-18909 DT denotes a
T9859 18910-18916 JJ denotes direct
T9860 18917-18928 NN denotes association
T9861 18929-18936 IN denotes between
T9862 18937-18948 NN denotes methylation
T9863 18949-18952 CC denotes and
T9864 18953-18961 NN denotes activity
T9865 18962-18964 IN denotes of
T9866 18965-18968 DT denotes the
T9867 18969-18974 NN denotes IRF-4
T9868 18975-18983 NN denotes promoter
T10256 18986-18990 NN denotes mRNA
T10257 18991-19001 NN denotes expression
T10258 19002-19004 IN denotes of
T10259 19005-19008 NN denotes DNA
T10260 19009-19027 NN denotes methyltransferases
T10261 19028-19031 CC denotes and
T10262 19032-19050 NN denotes methyl-CpG-binding
T10263 19051-19059 NN denotes proteins
T10264 19060-19063 MD denotes may
T10265 19064-19067 RB denotes not
T10266 19068-19070 VB denotes be
T10267 19071-19081 VB denotes associated
T10268 19082-19086 IN denotes with
T10269 19087-19092 NN denotes IRF-4
T10270 19093-19101 NN denotes promoter
T10271 19102-19113 NN denotes methylation
T10272 19114-19119 IN denotes Since
T10273 19120-19129 NN denotes abundance
T10274 19130-19132 IN denotes of
T10275 19133-19137 NN denotes DNMT
T10276 19138-19141 CC denotes and
T10277 19142-19145 NN denotes MBP
T10278 19146-19156 VB denotes contribute
T10279 19157-19159 TO denotes to
T10280 19160-19168 NN denotes promoter
T10281 19169-19179 NN denotes regulation
T10282 19180-19183 IN denotes via
T10283 19184-19195 NN denotes methylation
T10284 19196-19197 -LRB- denotes (
T10285 19197-19205 CD denotes 25,26,28
T10286 19205-19206 -RRB- denotes )
T10287 19206-19207 -COMMA- denotes ,
T10288 19208-19210 PRP denotes we
T10289 19211-19218 VB denotes studied
T10290 19219-19224 PRP-DOLLAR- denotes their
T10291 19225-19229 NN denotes mRNA
T10292 19230-19240 NN denotes expression
T10293 19241-19243 TO denotes to
T10294 19244-19255 VB denotes investigate
T10295 19256-19257 DT denotes a
T10296 19258-19266 JJ denotes possible
T10297 19267-19276 NN denotes mechanism
T10298 19277-19280 IN denotes for
T10299 19281-19284 DT denotes the
T10300 19285-19293 VB denotes observed
T10301 19294-19305 NN denotes methylation
T10302 19306-19317 NN denotes differences
T10303 19318-19320 IN denotes in
T10304 19321-19324 DT denotes the
T10305 19325-19330 NN denotes IRF-4
T10306 19331-19339 NN denotes promoter
T10307 19341-19343 TO denotes To
T10308 19344-19348 DT denotes this
T10309 19349-19352 NN denotes end
T10310 19352-19353 -COMMA- denotes ,
T10311 19354-19356 PRP denotes we
T10312 19357-19360 VB denotes did
T10313 19361-19364 RB denotes not
T10314 19365-19371 VB denotes detect
T10315 19372-19373 DT denotes a
T10316 19374-19385 JJ denotes significant
T10317 19386-19396 NN denotes difference
T10318 19397-19399 IN denotes in
T10319 19400-19404 NN denotes DNMT
T10320 19405-19406 -LRB- denotes (
T10321 19406-19411 NN denotes DNMT1
T10322 19411-19412 -COMMA- denotes ,
T10323 19413-19419 NN denotes DNMT3A
T10324 19420-19423 CC denotes and
T10325 19424-19430 NN denotes DNMT3B
T10326 19430-19431 -RRB- denotes )
T10327 19432-19434 CC denotes or
T10328 19435-19438 NN denotes MBP
T10329 19439-19440 -LRB- denotes (
T10330 19440-19444 NN denotes MBD1
T10331 19444-19445 -COMMA- denotes ,
T10332 19446-19450 NN denotes MBD2
T10333 19450-19451 -COMMA- denotes ,
T10334 19452-19456 NN denotes MBD4
T10335 19457-19460 CC denotes and
T10336 19461-19465 NN denotes MeCP
T10337 19465-19466 -RRB- denotes )
T10338 19467-19471 NN denotes mRNA
T10339 19472-19482 NN denotes expression
T10340 19483-19490 IN denotes between
T10341 19491-19505 JJ denotes IRF-4-positive
T10342 19506-19509 CC denotes and
T10343 19510-19519 JJ denotes -negative
T10344 19520-19525 NN denotes cells
T10345 19526-19527 -LRB- denotes (
T10346 19527-19533 NN denotes Figure
T10347 19534-19536 NN denotes 5D
T10348 19536-19537 -RRB- denotes )
T10349 19539-19541 IN denotes In
T10350 19542-19546 NN denotes fact
T10351 19546-19547 -COMMA- denotes ,
T10352 19548-19551 DT denotes all
T10353 19552-19560 VB denotes analyzed
T10354 19561-19566 NN denotes cells
T10355 19567-19570 VB denotes had
T10356 19571-19579 JJ denotes moderate
T10357 19580-19582 TO denotes to
T10358 19583-19587 JJ denotes high
T10359 19588-19592 NN denotes mRNA
T10360 19593-19599 NN denotes levels
T10361 19600-19602 IN denotes of
T10362 19603-19608 DT denotes these
T10363 19609-19615 VB denotes tested
T10364 19616-19625 NN denotes DNMT/MBPs
T10365 19626-19629 CC denotes and
T10366 19630-19641 NN denotes differences
T10367 19642-19644 IN denotes in
T10368 19645-19655 NN denotes expression
T10369 19656-19660 VB denotes were
T10370 19661-19664 RB denotes not
T10371 19665-19675 VB denotes correlated
T10372 19676-19680 IN denotes with
T10373 19681-19686 NN denotes IRF-4
T10374 19687-19693 NN denotes status
T10375 19695-19700 DT denotes These
T10376 19701-19708 NN denotes results
T10377 19709-19717 VB denotes indicate
T10378 19718-19719 DT denotes a
T10379 19720-19728 JJ denotes distinct
T10380 19729-19734 NN denotes cause
T10381 19735-19737 IN denotes of
T10382 19738-19741 DT denotes the
T10383 19742-19753 NN denotes methylation
T10384 19754-19765 NN denotes differences
T10385 19766-19768 IN denotes in
T10386 19769-19783 JJ denotes IRF-4-positive
T10387 19784-19787 CC denotes and
T10388 19788-19797 JJ denotes -negative
T10389 19798-19803 NN denotes cells
T10390 19804-19810 RB denotes rather
T10391 19811-19815 IN denotes than
T10392 19816-19823 NN denotes changes
T10393 19824-19826 IN denotes in
T10394 19827-19830 DT denotes the
T10395 19831-19835 NN denotes DNMT
T10396 19836-19839 CC denotes and
T10397 19840-19843 NN denotes MBP
T10398 19844-19848 NN denotes mRNA
T10399 19849-19862 NN denotes transcription
T11346 19876-19880 JJ denotes Many
T11347 19881-19888 JJ denotes genetic
T11348 19889-19896 NN denotes lesions
T11349 19897-19900 VB denotes are
T11350 19901-19906 VB denotes known
T11351 19907-19909 TO denotes to
T11352 19910-19919 VB denotes influence
T11353 19920-19924 NN denotes gene
T11354 19925-19935 NN denotes expression
T11355 19936-19938 IN denotes of
T11356 19939-19944 NN denotes tumor
T11357 19945-19955 NN denotes suppressor
T11358 19956-19961 NN denotes genes
T11359 19963-19970 IN denotes Whereas
T11360 19971-19980 NN denotes mutations
T11361 19981-19984 CC denotes and
T11362 19985-19994 NN denotes deletions
T11363 19995-19997 CC denotes or
T11364 19998-20008 NN denotes insertions
T11365 20009-20013 VB denotes have
T11366 20014-20023 JJ denotes permanent
T11367 20024-20031 NN denotes effects
T11368 20031-20032 -COMMA- denotes ,
T11369 20033-20043 JJ denotes reversible
T11370 20044-20054 NN denotes mechanisms
T11371 20055-20058 VB denotes are
T11372 20059-20063 NN denotes gene
T11373 20064-20075 NN denotes methylation
T11374 20075-20076 -COMMA- denotes ,
T11375 20077-20079 CC denotes or
T11376 20080-20090 NN denotes expression
T11377 20091-20094 CC denotes and
T11378 20095-20105 NN denotes activation
T11379 20106-20108 IN denotes of
T11380 20109-20122 NN denotes transcription
T11381 20123-20130 NN denotes factors
T11382 20130-20131 -COMMA- denotes ,
T11383 20132-20144 RB denotes respectively
T11384 20146-20148 PRP denotes We
T11385 20149-20156 VB denotes studied
T11386 20157-20158 DT denotes a
T11387 20159-20167 JJ denotes putative
T11388 20168-20173 NN denotes cause
T11389 20174-20177 IN denotes for
T11390 20178-20184 JJ denotes absent
T11391 20185-20190 NN denotes IRF-4
T11392 20191-20201 NN denotes expression
T11393 20202-20204 IN denotes in
T11394 20205-20213 NN denotes leukemia
T11395 20214-20219 NN denotes cells
T11396 20220-20223 CC denotes and
T11397 20224-20229 RB denotes first
T11398 20230-20237 VB denotes focused
T11399 20238-20240 IN denotes on
T11400 20241-20248 JJ denotes genetic
T11401 20249-20260 NN denotes aberrations
T11402 20261-20263 IN denotes of
T11403 20264-20267 DT denotes the
T11404 20268-20276 NN denotes promoter
T11405 20278-20280 PRP denotes We
T11406 20281-20289 VB denotes observed
T11407 20290-20292 DT denotes no
T11408 20293-20300 JJ denotes genetic
T11409 20301-20312 NN denotes alterations
T11410 20313-20315 IN denotes in
T11411 20316-20319 DT denotes the
T11412 20320-20325 NN denotes IRF-4
T11413 20326-20334 NN denotes promoter
T11414 20334-20335 -COMMA- denotes ,
T11415 20336-20341 WDT denotes which
T11416 20342-20345 MD denotes can
T11417 20346-20353 VB denotes account
T11418 20354-20357 IN denotes for
T11419 20358-20361 DT denotes the
T11420 20362-20366 NN denotes lack
T11421 20367-20369 IN denotes of
T11422 20370-20375 NN denotes IRF-4
T11423 20376-20386 NN denotes expression
T11424 20386-20387 -COLON- denotes :
T11425 20388-20391 DT denotes The
T11426 20392-20400 VB denotes detected
T11427 20401-20405 NN denotes base
T11428 20406-20410 NN denotes pair
T11429 20411-20418 NN denotes changes
T11430 20419-20421 IN denotes at
T11431 20422-20430 NN denotes position
T11432 20431-20436 NN denotes −1081
T11433 20437-20438 -LRB- denotes (
T11434 20438-20441 NN denotes T→C
T11435 20442-20454 NN denotes substitution
T11436 20454-20455 -RRB- denotes )
T11437 20455-20456 -COMMA- denotes ,
T11438 20457-20459 IN denotes at
T11439 20460-20468 NN denotes position
T11440 20469-20474 CD denotes −1068
T11441 20475-20476 -LRB- denotes (
T11442 20476-20479 NN denotes A→C
T11443 20480-20492 NN denotes substitution
T11444 20492-20493 -RRB- denotes )
T11445 20494-20497 CC denotes and
T11446 20498-20500 IN denotes at
T11447 20501-20509 NN denotes position
T11448 20510-20514 CD denotes −116
T11449 20515-20516 -LRB- denotes (
T11450 20516-20519 NN denotes A→C
T11451 20520-20532 NN denotes substitution
T11452 20532-20533 -RRB- denotes )
T11453 20534-20537 VB denotes are
T11454 20538-20546 JJ denotes unlikely
T11455 20547-20558 JJ denotes responsible
T11456 20559-20562 IN denotes for
T11457 20563-20569 JJ denotes absent
T11458 20570-20586 NN denotes IRF-4-expression
T11459 20587-20592 IN denotes since
T11460 20593-20596 DT denotes the
T11461 20597-20602 JJ denotes first
T11462 20603-20606 CD denotes two
T11463 20607-20616 NN denotes mutations
T11464 20617-20621 VB denotes were
T11465 20622-20627 VB denotes found
T11466 20628-20632 CC denotes both
T11467 20633-20635 IN denotes in
T11468 20636-20650 JJ denotes IRF-4-positive
T11469 20651-20654 CC denotes and
T11470 20655-20664 JJ denotes -negative
T11471 20665-20670 NN denotes cells
T11472 20671-20678 IN denotes whereas
T11473 20679-20682 DT denotes the
T11474 20683-20689 JJ denotes latter
T11475 20690-20696 NN denotes change
T11476 20697-20700 VB denotes was
T11477 20701-20704 RB denotes not
T11478 20705-20713 VB denotes detected
T11479 20714-20726 RB denotes consistently
T11480 20727-20729 IN denotes in
T11481 20730-20733 DT denotes all
T11482 20734-20748 JJ denotes IRF-4-negative
T11483 20749-20751 CC denotes or
T11484 20752-20761 JJ denotes -positive
T11485 20762-20767 NN denotes cells
T11486 20768-20771 CC denotes and
T11487 20772-20775 MD denotes may
T11488 20776-20780 RB denotes thus
T11489 20781-20783 VB denotes be
T11490 20784-20785 DT denotes a
T11491 20786-20798 NN denotes polymorphism
T11492 20800-20803 DT denotes All
T11493 20804-20809 CD denotes three
T11494 20810-20823 NN denotes substitutions
T11495 20824-20827 VB denotes did
T11496 20828-20831 RB denotes not
T11497 20832-20838 VB denotes change
T11498 20839-20842 DT denotes any
T11499 20843-20848 JJ denotes known
T11500 20849-20857 JJ denotes putative
T11501 20858-20871 NN denotes transcription
T11502 20872-20878 NN denotes factor
T11503 20879-20886 NN denotes binding
T11504 20887-20892 NN denotes sites
T11505 20893-20894 -LRB- denotes (
T11506 20894-20899 CD denotes 30,31
T11507 20899-20900 -RRB- denotes )
T11508 20901-20904 CC denotes and
T11509 20905-20909 RB denotes also
T11510 20910-20912 VB denotes do
T11511 20913-20916 RB denotes not
T11512 20917-20923 VB denotes affect
T11513 20924-20927 DT denotes any
T11514 20928-20939 NN denotes restriction
T11515 20940-20945 NN denotes sites
T11516 20946-20948 CC denotes or
T11517 20949-20955 NN denotes primer
T11518 20956-20963 NN denotes binding
T11519 20964-20969 NN denotes sites
T11520 20970-20972 IN denotes of
T11521 20973-20976 DT denotes the
T11522 20977-20981 VB denotes used
T11523 20982-20988 NN denotes assays
T11524 20990-20997 RB denotes However
T11525 20997-20998 -COMMA- denotes ,
T11526 20999-21008 JJ denotes permanent
T11527 21009-21016 JJ denotes genetic
T11528 21017-21027 NN denotes variations
T11529 21028-21030 IN denotes in
T11530 21031-21034 DT denotes the
T11531 21035-21040 NN denotes IRF-4
T11532 21041-21047 NN denotes coding
T11533 21048-21056 NN denotes sequence
T11534 21056-21057 -COMMA- denotes ,
T11535 21058-21062 JJ denotes such
T11536 21063-21065 IN denotes as
T11537 21066-21075 NN denotes deletions
T11538 21076-21078 CC denotes or
T11539 21079-21088 NN denotes mutations
T11540 21089-21098 VB denotes resulting
T11541 21099-21101 IN denotes in
T11542 21102-21113 NN denotes stop-codons
T11543 21114-21118 VB denotes have
T11544 21119-21122 RB denotes not
T11545 21123-21127 VB denotes been
T11546 21128-21136 VB denotes excluded
T11547 21137-21139 IN denotes by
T11548 21140-21148 NN denotes sequence
T11549 21149-21157 NN denotes analysis
T11550 21159-21164 IN denotes Since
T11551 21165-21170 NN denotes IRF-4
T11552 21171-21181 NN denotes expression
T11553 21182-21184 IN denotes in
T11554 21185-21189 NN denotes cell
T11555 21190-21195 NN denotes lines
T11556 21196-21199 CC denotes and
T11557 21200-21203 NN denotes CML
T11558 21204-21207 MD denotes can
T11559 21208-21210 VB denotes be
T11560 21211-21218 VB denotes induced
T11561 21219-21221 IN denotes by
T11562 21222-21235 NN denotes demethylation
T11563 21236-21239 CC denotes and
T11564 21240-21250 JJ denotes successful
T11565 21251-21256 NN denotes IFN-α
T11566 21257-21264 NN denotes therapy
T11567 21265-21266 -LRB- denotes (
T11568 21266-21267 CD denotes 3
T11569 21267-21268 -RRB- denotes )
T11570 21268-21269 -COMMA- denotes ,
T11571 21270-21282 RB denotes respectively
T11572 21282-21283 -COMMA- denotes ,
T11573 21284-21287 DT denotes the
T11574 21288-21297 NN denotes existence
T11575 21298-21300 IN denotes of
T11576 21301-21305 JJ denotes such
T11577 21306-21313 JJ denotes genetic
T11578 21314-21325 NN denotes aberrations
T11579 21326-21331 VB denotes seems
T11580 21332-21340 JJ denotes unlikely
T11581 21342-21344 PRP denotes We
T11582 21345-21349 RB denotes then
T11583 21350-21362 VB denotes investigated
T11584 21363-21370 IN denotes whether
T11585 21371-21374 DT denotes the
T11586 21375-21385 RB denotes previously
T11587 21386-21395 VB denotes described
T11588 21396-21411 NN denotes down-regulation
T11589 21412-21414 IN denotes of
T11590 21415-21420 NN denotes IRF-4
T11591 21421-21431 NN denotes expression
T11592 21432-21434 IN denotes in
T11593 21435-21440 JJ denotes human
T11594 21441-21448 JJ denotes myeloid
T11595 21449-21458 NN denotes leukemias
T11596 21459-21462 VB denotes was
T11597 21463-21466 JJ denotes due
T11598 21467-21469 TO denotes to
T11599 21470-21471 DT denotes a
T11600 21472-21484 JJ denotes differential
T11601 21485-21501 NN denotes hypermethylation
T11602 21502-21504 IN denotes of
T11603 21505-21508 DT denotes the
T11604 21509-21517 NN denotes promoter
T11605 21517-21518 -COMMA- denotes ,
T11606 21519-21524 IN denotes since
T11607 21525-21528 DT denotes the
T11608 21529-21538 VB denotes presented
T11609 21539-21552 NN denotes re-expression
T11610 21553-21556 IN denotes due
T11611 21557-21559 TO denotes to
T11612 21560-21575 NN denotes AzadC-treatment
T11613 21576-21581 MD denotes might
T11614 21582-21586 RB denotes also
T11615 21587-21589 VB denotes be
T11616 21590-21591 DT denotes a
T11617 21592-21598 NN denotes result
T11618 21599-21601 IN denotes of
T11619 21602-21612 NN denotes activation
T11620 21613-21615 IN denotes of
T11621 21616-21624 JJ denotes positive
T11622 21625-21640 JJ denotes transcriptional
T11623 21641-21651 NN denotes regulators
T11624 21652-21654 IN denotes of
T11625 21655-21660 NN denotes IRF-4
T11626 21662-21673 NN denotes Methylation
T11627 21674-21676 IN denotes of
T11628 21677-21680 NN denotes CpG
T11629 21681-21686 NN denotes sites
T11630 21687-21689 VB denotes is
T11631 21690-21691 DT denotes a
T11632 21692-21698 JJ denotes common
T11633 21699-21708 NN denotes mechanism
T11634 21709-21711 IN denotes of
T11635 21712-21721 NN denotes silencing
T11636 21722-21727 NN denotes genes
T11637 21728-21730 IN denotes in
T11638 21731-21739 NN denotes leukemia
T11639 21740-21743 CC denotes and
T11640 21744-21747 VB denotes has
T11641 21748-21752 RB denotes also
T11642 21753-21757 VB denotes been
T11643 21758-21763 VB denotes shown
T11644 21764-21767 IN denotes for
T11645 21768-21775 DT denotes another
T11646 21776-21779 NN denotes IRF
T11647 21779-21780 -COMMA- denotes ,
T11648 21781-21786 NN denotes IRF-7
T11649 21787-21788 -LRB- denotes (
T11650 21788-21790 CD denotes 35
T11651 21790-21791 -RRB- denotes )
T11652 21792-21795 CC denotes and
T11653 21796-21799 IN denotes for
T11654 21800-21804 NN denotes PU.1
T11655 21805-21806 -LRB- denotes (
T11656 21806-21808 CD denotes 36
T11657 21808-21809 -RRB- denotes )
T11658 21809-21810 -COMMA- denotes ,
T11659 21811-21813 DT denotes an
T11660 21814-21825 VB denotes interacting
T11661 21826-21833 NN denotes partner
T11662 21834-21836 IN denotes of
T11663 21837-21842 NN denotes IRF-4
T11664 21844-21846 TO denotes To
T11665 21847-21856 VB denotes elucidate
T11666 21857-21860 DT denotes the
T11667 21861-21870 NN denotes relevance
T11668 21871-21873 IN denotes of
T11669 21874-21878 DT denotes this
T11670 21879-21888 NN denotes mechanism
T11671 21889-21892 IN denotes for
T11672 21893-21896 DT denotes the
T11673 21897-21907 NN denotes regulation
T11674 21908-21910 IN denotes of
T11675 21911-21916 NN denotes IRF-4
T11676 21917-21927 NN denotes expression
T11677 21927-21928 -COMMA- denotes ,
T11678 21929-21936 JJ denotes various
T11679 21937-21945 JJ denotes leukemic
T11680 21946-21951 NN denotes cells
T11681 21952-21956 VB denotes were
T11682 21957-21964 VB denotes treated
T11683 21965-21969 IN denotes with
T11684 21970-21983 VB denotes demethylating
T11685 21984-21990 NN denotes agents
T11686 21991-21994 CC denotes and
T11687 21995-22004 NN denotes promoters
T11688 22005-22009 VB denotes were
T11689 22010-22019 VB denotes sequenced
T11690 22020-22025 IN denotes after
T11691 22026-22035 NN denotes bisulfite
T11692 22036-22045 NN denotes treatment
T11693 22047-22049 PRP denotes We
T11694 22050-22055 VB denotes found
T11695 22056-22060 IN denotes that
T11696 22061-22066 NN denotes IRF-4
T11697 22067-22077 NN denotes expression
T11698 22078-22083 MD denotes could
T11699 22084-22090 RB denotes indeed
T11700 22091-22093 VB denotes be
T11701 22094-22103 VB denotes connected
T11702 22104-22106 TO denotes to
T11703 22107-22110 DT denotes the
T11704 22111-22122 NN denotes methylation
T11705 22123-22129 NN denotes status
T11706 22130-22132 IN denotes of
T11707 22133-22141 JJ denotes distinct
T11708 22142-22145 NN denotes CpG
T11709 22146-22152 NN denotes motifs
T11710 22153-22155 IN denotes in
T11711 22156-22159 DT denotes the
T11712 22160-22165 NN denotes IRF-4
T11713 22166-22174 NN denotes promoter
T11714 22176-22178 IN denotes In
T11715 22179-22185 NN denotes Figure
T11716 22186-22188 NN denotes 4A
T11717 22188-22189 -COMMA- denotes ,
T11718 22190-22195 DT denotes those
T11719 22196-22199 NN denotes CpG
T11720 22200-22205 NN denotes sites
T11721 22206-22209 VB denotes are
T11722 22210-22215 VB denotes shown
T11723 22216-22217 -LRB- denotes (
T11724 22217-22223 JJ denotes bottom
T11725 22224-22228 NN denotes line
T11726 22228-22229 -RRB- denotes )
T11727 22229-22230 -COMMA- denotes ,
T11728 22231-22236 WP-DOLLAR- denotes whose
T11729 22237-22253 NN denotes hypermethylation
T11730 22254-22257 MD denotes may
T11731 22258-22265 VB denotes account
T11732 22266-22269 IN denotes for
T11733 22270-22273 DT denotes the
T11734 22274-22281 NN denotes absence
T11735 22282-22284 IN denotes of
T11736 22285-22290 NN denotes IRF-4
T11737 22291-22301 NN denotes expression
T11738 22302-22304 IN denotes in
T11739 22305-22308 DT denotes the
T11740 22309-22319 JJ denotes respective
T11741 22320-22325 NN denotes cells
T11742 22327-22330 CD denotes One
T11743 22331-22333 IN denotes of
T11744 22334-22338 PRP denotes them
T11745 22339-22340 -LRB- denotes (
T11746 22340-22341 -SHARP- denotes #
T11747 22341-22343 CD denotes 54
T11748 22343-22344 -RRB- denotes )
T11749 22345-22347 VB denotes is
T11750 22348-22356 JJ denotes adjacent
T11751 22357-22359 TO denotes to
T11752 22360-22362 DT denotes an
T11753 22363-22373 VB denotes identified
T11754 22374-22384 JJ denotes regulatory
T11755 22385-22392 NN denotes element
T11756 22393-22394 -LRB- denotes (
T11757 22394-22403 NN denotes NFκB-site
T11758 22403-22404 -RRB- denotes )
T11759 22404-22405 -COMMA- denotes ,
T11760 22406-22416 VB denotes indicating
T11761 22417-22418 DT denotes a
T11762 22419-22427 JJ denotes possible
T11763 22428-22439 NN denotes involvement
T11764 22440-22442 IN denotes of
T11765 22443-22447 DT denotes this
T11766 22448-22452 NN denotes site
T11767 22454-22456 IN denotes At
T11768 22457-22460 CD denotes two
T11769 22461-22468 JJ denotes further
T11770 22469-22472 NN denotes CpG
T11771 22473-22478 NN denotes sites
T11772 22479-22480 -LRB- denotes (
T11773 22480-22481 -SHARP- denotes #
T11774 22481-22483 CD denotes 48
T11775 22483-22484 -COMMA- denotes ,
T11776 22485-22487 CD denotes 45
T11777 22487-22488 -RRB- denotes )
T11778 22489-22492 DT denotes the
T11779 22493-22504 NN denotes methylation
T11780 22505-22511 NN denotes status
T11781 22512-22514 IN denotes in
T11782 22515-22529 JJ denotes IRF-4-positive
T11783 22530-22533 VB denotes was
T11784 22534-22539 JJ denotes lower
T11785 22540-22544 IN denotes than
T11786 22545-22549 DT denotes that
T11787 22550-22552 IN denotes of
T11788 22553-22567 JJ denotes IRF-4-negative
T11789 22568-22573 NN denotes cells
T11790 22575-22580 DT denotes These
T11791 22581-22584 NN denotes CpG
T11792 22585-22590 NN denotes sites
T11793 22591-22594 VB denotes are
T11794 22595-22602 JJ denotes located
T11795 22603-22605 IN denotes in
T11796 22606-22608 DT denotes an
T11797 22609-22613 NN denotes NFκB
T11798 22614-22617 CC denotes and
T11799 22618-22620 DT denotes an
T11800 22621-22624 NN denotes SP1
T11801 22625-22632 NN denotes element
T11802 22633-22634 -LRB- denotes (
T11803 22634-22636 CD denotes 31
T11804 22636-22637 -RRB- denotes )
T11805 22638-22641 CC denotes and
T11806 22642-22646 RB denotes thus
T11807 22647-22650 MD denotes may
T11808 22651-22655 RB denotes also
T11809 22656-22660 VB denotes play
T11810 22661-22662 DT denotes a
T11811 22663-22667 NN denotes role
T11812 22668-22670 IN denotes in
T11813 22671-22681 NN denotes regulation
T11814 22682-22684 IN denotes of
T11815 22685-22690 NN denotes IRF-4
T11816 22691-22701 NN denotes expression
T11817 22703-22705 PRP denotes It
T11818 22706-22709 VB denotes has
T11819 22710-22714 VB denotes been
T11820 22715-22720 VB denotes shown
T11821 22721-22725 IN denotes that
T11822 22726-22730 NN denotes NFκB
T11823 22731-22739 NN denotes elements
T11824 22740-22744 VB denotes play
T11825 22745-22747 DT denotes an
T11826 22748-22757 JJ denotes important
T11827 22758-22762 NN denotes role
T11828 22763-22765 IN denotes in
T11829 22766-22771 NN denotes IRF-4
T11830 22772-22781 NN denotes induction
T11831 22782-22784 IN denotes as
T11832 22785-22790 NN denotes IRF-4
T11833 22791-22801 NN denotes expression
T11834 22802-22809 VB denotes depends
T11835 22810-22812 IN denotes on
T11836 22813-22820 NN denotes binding
T11837 22821-22823 IN denotes of
T11838 22824-22827 DT denotes the
T11839 22828-22842 NN denotes transactivator
T11840 22843-22848 NN denotes c-Rel
T11841 22849-22851 TO denotes to
T11842 22852-22857 DT denotes these
T11843 22858-22866 NN denotes elements
T11844 22867-22869 IN denotes in
T11845 22870-22873 DT denotes the
T11846 22874-22879 NN denotes IRF-4
T11847 22880-22888 NN denotes promoter
T11848 22889-22890 -LRB- denotes (
T11849 22890-22895 CD denotes 31,37
T11850 22895-22896 -RRB- denotes )
T11851 22898-22909 RB denotes Furthermore
T11852 22909-22910 -COMMA- denotes ,
T11853 22911-22922 NN denotes methylation
T11854 22923-22925 IN denotes of
T11855 22926-22929 DT denotes the
T11856 22930-22937 JJ denotes central
T11857 22938-22941 NN denotes CpG
T11858 22942-22944 IN denotes in
T11859 22945-22948 DT denotes the
T11860 22949-22953 NN denotes NFκB
T11861 22954-22961 NN denotes element
T11862 22962-22970 VB denotes inhibits
T11863 22971-22978 NN denotes binding
T11864 22979-22981 IN denotes of
T11865 22982-22985 DT denotes the
T11866 22986-22990 NN denotes NFκB
T11867 22991-22998 NN denotes protein
T11868 22999-23008 NN denotes complexes
T11869 23009-23010 -LRB- denotes (
T11870 23010-23012 CD denotes 38
T11871 23012-23013 -RRB- denotes )
T11872 23013-23014 -COMMA- denotes ,
T11873 23015-23024 VB denotes promoting
T11874 23025-23028 DT denotes the
T11875 23029-23041 NN denotes significance
T11876 23042-23044 IN denotes of
T11877 23045-23048 DT denotes the
T11878 23049-23057 VB denotes observed
T11879 23058-23069 NN denotes methylation
T11880 23070-23081 NN denotes differences
T11881 23082-23084 IN denotes in
T11882 23085-23099 JJ denotes IRF-4-positive
T11883 23100-23103 CC denotes and
T11884 23104-23113 JJ denotes -negative
T11885 23114-23119 NN denotes cells
T11886 23121-23124 NNP denotes Via
T11887 23125-23127 FW denotes in
T11888 23128-23133 FW denotes vitro
T11889 23134-23145 NN denotes methylation
T11890 23146-23149 CC denotes and
T11891 23150-23158 NN denotes reporter
T11892 23159-23163 NN denotes gene
T11893 23164-23170 NN denotes assays
T11894 23171-23173 PRP denotes we
T11895 23174-23179 MD denotes could
T11896 23180-23187 RB denotes clearly
T11897 23188-23195 VB denotes appoint
T11898 23196-23199 DT denotes the
T11899 23200-23209 NN denotes silencing
T11900 23210-23212 IN denotes of
T11901 23213-23216 DT denotes the
T11902 23217-23222 NN denotes IRF-4
T11903 23223-23231 NN denotes promoter
T11904 23232-23234 TO denotes to
T11905 23235-23236 DT denotes a
T11906 23237-23248 NN denotes methylation
T11907 23249-23255 NN denotes effect
T11908 23255-23256 -COMMA- denotes ,
T11909 23257-23262 WDT denotes which
T11910 23263-23266 MD denotes may
T11911 23267-23271 RB denotes thus
T11912 23272-23274 VB denotes be
T11913 23275-23278 DT denotes the
T11914 23279-23288 NN denotes mechanism
T11915 23289-23291 IN denotes of
T11916 23292-23297 NN denotes IRF-4
T11917 23298-23310 NN denotes deregulation
T11918 23311-23313 FW denotes in
T11919 23314-23318 FW denotes vivo
T11920 23320-23323 CD denotes One
T11921 23324-23332 JJ denotes possible
T11922 23333-23338 NN denotes cause
T11923 23339-23342 IN denotes for
T11924 23343-23346 DT denotes the
T11925 23347-23355 JJ denotes aberrant
T11926 23356-23367 NN denotes methylation
T11927 23368-23370 IN denotes in
T11928 23371-23384 NN denotes tumorigenesis
T11929 23385-23387 VB denotes is
T11930 23388-23390 DT denotes an
T11931 23391-23400 VB denotes increased
T11932 23401-23406 NN denotes level
T11933 23407-23409 IN denotes of
T11934 23410-23415 NN denotes DNMTs
T11935 23416-23422 IN denotes during
T11936 23423-23426 DT denotes the
T11937 23427-23439 JJ denotes pathogenetic
T11938 23440-23447 NN denotes process
T11939 23449-23451 IN denotes In
T11940 23452-23457 NN denotes colon
T11941 23457-23458 -COMMA- denotes ,
T11942 23459-23463 NN denotes lung
T11943 23464-23467 CC denotes and
T11944 23468-23479 JJ denotes hematologic
T11945 23480-23492 NN denotes malignancies
T11946 23492-23493 -COMMA- denotes ,
T11947 23494-23508 NN denotes overexpression
T11948 23509-23511 IN denotes of
T11949 23512-23517 NN denotes DNMT1
T11950 23517-23518 -COMMA- denotes ,
T11951 23519-23520 DT denotes a
T11952 23521-23532 NN denotes maintenance
T11953 23533-23537 NN denotes DNMT
T11954 23537-23538 -COMMA- denotes ,
T11955 23539-23542 VB denotes has
T11956 23543-23547 VB denotes been
T11957 23548-23556 VB denotes detected
T11958 23557-23558 -LRB- denotes (
T11959 23558-23563 CD denotes 39–41
T11960 23563-23564 -RRB- denotes )
T11961 23566-23577 RB denotes Furthermore
T11962 23577-23578 -COMMA- denotes ,
T11963 23579-23581 PRP denotes it
T11964 23582-23585 VB denotes has
T11965 23586-23590 VB denotes been
T11966 23591-23596 VB denotes shown
T11967 23597-23601 IN denotes that
T11968 23602-23605 NN denotes CML
T11969 23606-23611 NN denotes cells
T11970 23612-23614 IN denotes in
T11971 23615-23618 DT denotes the
T11972 23619-23624 JJ denotes acute
T11973 23625-23630 NN denotes phase
T11974 23631-23640 VB denotes exhibited
T11975 23641-23649 JJ denotes elevated
T11976 23650-23656 NN denotes levels
T11977 23657-23659 IN denotes of
T11978 23660-23663 DT denotes the
T11979 23664-23669 CD denotes three
T11980 23670-23675 VB denotes known
T11981 23676-23681 NN denotes DNMTs
T11982 23681-23682 -COMMA- denotes ,
T11983 23683-23688 IN denotes while
T11984 23689-23692 NN denotes CML
T11985 23693-23698 NN denotes cells
T11986 23699-23701 IN denotes in
T11987 23702-23709 JJ denotes chronic
T11988 23710-23715 NN denotes phase
T11989 23716-23725 VB denotes expressed
T11990 23726-23732 JJ denotes normal
T11991 23733-23739 NN denotes levels
T11992 23740-23742 IN denotes of
T11993 23743-23748 NN denotes DNMTs
T11994 23749-23751 IN denotes if
T11995 23752-23760 VB denotes compared
T11996 23761-23765 IN denotes with
T11997 23766-23772 JJ denotes normal
T11998 23773-23777 NN denotes bone
T11999 23778-23784 NN denotes marrow
T12000 23785-23790 NN denotes cells
T12001 23791-23792 -LRB- denotes (
T12002 23792-23794 CD denotes 25
T12003 23794-23795 -RRB- denotes )
T12004 23797-23810 RB denotes Interestingly
T12005 23810-23811 -COMMA- denotes ,
T12006 23812-23813 DT denotes a
T12007 23814-23822 JJ denotes positive
T12008 23823-23834 NN denotes correlation
T12009 23835-23842 IN denotes between
T12010 23843-23848 NN denotes DNMT1
T12011 23849-23859 NN denotes expression
T12012 23860-23866 NN denotes levels
T12013 23867-23870 CC denotes and
T12014 23871-23887 NN denotes hypermethylation
T12015 23888-23890 IN denotes of
T12016 23891-23899 NN denotes p15INK4b
T12017 23900-23903 VB denotes has
T12018 23904-23908 VB denotes been
T12019 23909-23917 VB denotes detected
T12020 23918-23920 IN denotes in
T12021 23921-23924 NN denotes AML
T12022 23925-23926 -LRB- denotes (
T12023 23926-23928 CD denotes 25
T12024 23928-23929 -RRB- denotes )
T12025 23931-23933 IN denotes In
T12026 23934-23938 DT denotes this
T12027 23939-23943 NN denotes work
T12028 23943-23944 -COMMA- denotes ,
T12029 23945-23947 PRP denotes we
T12030 23948-23951 VB denotes did
T12031 23952-23955 RB denotes not
T12032 23956-23962 VB denotes detect
T12033 23963-23974 JJ denotes significant
T12034 23975-23979 NN denotes mRNA
T12035 23980-23990 NN denotes expression
T12036 23991-24002 NN denotes differences
T12037 24003-24005 IN denotes of
T12038 24006-24014 VB denotes selected
T12039 24015-24019 NN denotes DNMT
T12040 24020-24022 CC denotes or
T12041 24023-24026 NN denotes MBP
T12042 24026-24027 -COMMA- denotes ,
T12043 24028-24034 VB denotes making
T12044 24035-24037 PRP denotes it
T12045 24038-24040 DT denotes an
T12046 24041-24049 JJ denotes unlikely
T12047 24050-24055 NN denotes cause
T12048 24056-24059 IN denotes for
T12049 24060-24063 DT denotes the
T12050 24064-24072 VB denotes observed
T12051 24073-24084 NN denotes methylation
T12052 24085-24088 CC denotes and
T12053 24089-24093 RB denotes thus
T12054 24094-24099 NN denotes IRF-4
T12055 24100-24110 NN denotes expression
T12056 24111-24122 NN denotes differences
T12057 24123-24125 IN denotes in
T12058 24126-24134 NN denotes leukemia
T12059 24135-24140 NN denotes cells
T12060 24142-24145 DT denotes The
T12061 24146-24153 NN denotes finding
T12062 24154-24158 IN denotes that
T12063 24159-24164 NN denotes IRF-4
T12064 24165-24175 NN denotes expression
T12065 24176-24178 VB denotes is
T12066 24179-24187 VB denotes silenced
T12067 24188-24190 IN denotes by
T12068 24191-24199 NN denotes promoter
T12069 24200-24216 NN denotes hypermethylation
T12070 24217-24222 MD denotes might
T12071 24223-24232 VB denotes represent
T12072 24233-24234 DT denotes a
T12073 24235-24244 NN denotes mechanism
T12074 24245-24249 WDT denotes that
T12075 24250-24258 VB denotes accounts
T12076 24259-24262 IN denotes for
T12077 24263-24266 DT denotes the
T12078 24267-24277 RB denotes previously
T12079 24278-24286 VB denotes observed
T12080 24287-24291 NN denotes loss
T12081 24292-24294 IN denotes of
T12082 24295-24300 NN denotes IRF-4
T12083 24301-24311 NN denotes expression
T12084 24312-24314 IN denotes in
T12085 24315-24318 NN denotes CML
T12086 24320-24326 RB denotes Indeed
T12087 24326-24327 -COMMA- denotes ,
T12088 24328-24335 JJ denotes several
T12089 24336-24344 JJ denotes clinical
T12090 24345-24351 NN denotes trials
T12091 24352-24356 IN denotes with
T12092 24357-24365 NN denotes leukemia
T12093 24366-24374 NN denotes patients
T12094 24375-24378 CC denotes and
T12095 24379-24387 NN denotes patients
T12096 24388-24392 IN denotes with
T12097 24393-24408 JJ denotes myelodysplastic
T12098 24409-24418 NN denotes syndromes
T12099 24419-24431 VB denotes demonstrated
T12100 24432-24435 DT denotes the
T12101 24436-24445 JJ denotes potential
T12102 24446-24454 JJ denotes clinical
T12103 24455-24462 NN denotes benefit
T12104 24463-24465 IN denotes of
T12105 24466-24467 DT denotes a
T12106 24468-24477 NN denotes treatment
T12107 24478-24482 IN denotes with
T12108 24483-24496 VB denotes demethylating
T12109 24497-24503 NN denotes agents
T12110 24504-24505 -LRB- denotes (
T12111 24505-24510 CD denotes 42–45
T12112 24510-24511 -RRB- denotes )
T12113 24513-24516 DT denotes The
T12114 24517-24527 NN denotes expression
T12115 24528-24530 IN denotes of
T12116 24531-24538 DT denotes another
T12117 24539-24542 NN denotes IRF
T12118 24542-24543 -COMMA- denotes ,
T12119 24544-24547 NN denotes IFN
T12120 24548-24557 NN denotes consensus
T12121 24558-24566 NN denotes sequence
T12122 24567-24574 NN denotes binding
T12123 24575-24582 NN denotes protein
T12124 24583-24584 -LRB- denotes (
T12125 24584-24595 NN denotes ICSBP/IRF-8
T12126 24595-24596 -RRB- denotes )
T12127 24596-24597 -COMMA- denotes ,
T12128 24598-24600 VB denotes is
T12129 24601-24609 JJ denotes impaired
T12130 24610-24612 IN denotes in
T12131 24613-24620 JJ denotes myeloid
T12132 24621-24630 NN denotes leukemias
T12133 24631-24641 RB denotes especially
T12134 24642-24645 NN denotes CML
T12135 24646-24647 -LRB- denotes (
T12136 24647-24655 CD denotes 27,46,47
T12137 24655-24656 -RRB- denotes )
T12138 24658-24661 CC denotes But
T12139 24662-24664 IN denotes in
T12140 24665-24673 NN denotes contrast
T12141 24674-24676 TO denotes to
T12142 24677-24682 NN denotes IRF-4
T12143 24682-24683 -COMMA- denotes ,
T12144 24684-24687 DT denotes the
T12145 24688-24692 NN denotes loss
T12146 24693-24695 IN denotes of
T12147 24696-24700 DT denotes this
T12148 24701-24704 NN denotes IRF
T12149 24705-24710 MD denotes could
T12150 24711-24714 RB denotes not
T12151 24715-24717 VB denotes be
T12152 24718-24726 VB denotes reverted
T12153 24727-24729 IN denotes in
T12154 24730-24744 JJ denotes ICSBP-negative
T12155 24745-24749 NN denotes cell
T12156 24750-24755 NN denotes lines
T12157 24756-24757 -LRB- denotes (
T12158 24757-24761 NN denotes EM-2
T12159 24761-24762 -COMMA- denotes ,
T12160 24763-24769 NN denotes CML-T1
T12161 24769-24770 -COMMA- denotes ,
T12162 24771-24776 NN denotes K-562
T12163 24777-24780 CC denotes and
T12164 24781-24788 NN denotes LAMA-84
T12165 24788-24789 -RRB- denotes )
T12166 24790-24792 IN denotes by
T12167 24793-24802 NN denotes treatment
T12168 24803-24807 IN denotes with
T12169 24808-24813 NN denotes AzadC
T12170 24814-24815 -LRB- denotes (
T12171 24815-24821 NN denotes Figure
T12172 24822-24823 CD denotes 6
T12173 24823-24824 -RRB- denotes )
T12174 24825-24828 CC denotes and
T12175 24829-24834 NN denotes AzadC
T12176 24835-24838 VB denotes has
T12177 24839-24841 DT denotes no
T12178 24842-24848 NN denotes effect
T12179 24849-24851 IN denotes on
T12180 24852-24857 NN denotes ICSBP
T12181 24858-24864 NN denotes levels
T12182 24865-24867 IN denotes in
T12183 24868-24882 JJ denotes ICSBP-positive
T12184 24883-24888 NN denotes U-937
T12185 24889-24894 NN denotes cells
T12186 24895-24896 -LRB- denotes (
T12187 24896-24902 NN denotes Figure
T12188 24903-24904 CD denotes 6
T12189 24904-24905 -RRB- denotes )
T12190 24907-24912 DT denotes These
T12191 24913-24917 NN denotes data
T12192 24918-24925 VB denotes suggest
T12193 24926-24927 DT denotes a
T12194 24928-24936 JJ denotes distinct
T12195 24937-24947 JJ denotes regulatory
T12196 24948-24957 NN denotes mechanism
T12197 24958-24961 IN denotes for
T12198 24962-24967 DT denotes these
T12199 24968-24971 CD denotes two
T12200 24972-24976 NN denotes IRFs
T12201 24978-24983 NN denotes IRF-4
T12202 24983-24984 -COMMA- denotes ,
T12203 24985-24992 JJ denotes similar
T12204 24993-24995 TO denotes to
T12205 24996-25000 JJ denotes many
T12206 25001-25006 JJ denotes other
T12207 25007-25016 JJ denotes classical
T12208 25017-25022 NN denotes tumor
T12209 25023-25033 NN denotes suppressor
T12210 25034-25039 NN denotes genes
T12211 25040-25048 NN denotes p15INK4b
T12212 25048-25049 -COMMA- denotes ,
T12213 25050-25058 NN denotes p16INK4a
T12214 25059-25061 CC denotes or
T12215 25062-25065 NN denotes p53
T12216 25065-25066 -COMMA- denotes ,
T12217 25067-25070 MD denotes may
T12218 25071-25075 RB denotes thus
T12219 25076-25078 VB denotes be
T12220 25079-25080 DT denotes a
T12221 25081-25088 NN denotes subject
T12222 25089-25091 IN denotes of
T12223 25092-25103 NN denotes alterations
T12224 25104-25106 IN denotes in
T12225 25107-25110 DT denotes the
T12226 25111-25119 NN denotes promoter
T12227 25120-25131 NN denotes methylation
T12228 25132-25138 NN denotes status
T12229 25139-25146 VB denotes leading
T12230 25147-25149 TO denotes to
T12231 25150-25160 NN denotes expression
T12232 25161-25168 NN denotes changes
T12233 25168-25169 -COMMA- denotes ,
T12234 25170-25175 WDT denotes which
T12235 25176-25181 MD denotes might
T12236 25182-25192 VB denotes contribute
T12237 25193-25195 TO denotes to
T12238 25196-25199 DT denotes the
T12239 25200-25210 NN denotes initiation
T12240 25211-25217 CC denotes and/or
T12241 25218-25229 NN denotes progression
T12242 25230-25232 IN denotes of
T12243 25233-25239 NN denotes cancer
T12244 25241-25246 RB denotes Still
T12245 25246-25247 -COMMA- denotes ,
T12246 25248-25251 DT denotes the
T12247 25252-25259 JJ denotes obvious
T12248 25260-25270 JJ denotes functional
T12249 25271-25280 NN denotes diversity
T12250 25281-25283 IN denotes of
T12251 25284-25289 NN denotes IRF-4
T12252 25290-25297 VB denotes remains
T12253 25298-25308 JJ denotes remarkable
T12254 25309-25312 CC denotes and
T12255 25313-25316 MD denotes can
T12256 25316-25319 RB denotes not
T12257 25320-25322 VB denotes be
T12258 25323-25328 RB denotes fully
T12259 25329-25338 VB denotes explained
T12260 25339-25341 IN denotes by
T12261 25342-25345 DT denotes the
T12262 25346-25351 NN denotes IRF-4
T12263 25352-25360 NN denotes promoter
T12264 25361-25372 NN denotes methylation
T12265 25373-25379 NN denotes status
T12266 25381-25384 IN denotes For
T12267 25385-25392 NN denotes example
T12268 25392-25393 -COMMA- denotes ,
T12269 25394-25399 NN denotes IRF-4
T12270 25400-25402 VB denotes is
T12271 25403-25412 RB denotes primarily
T12272 25413-25418 VB denotes known
T12273 25419-25422 IN denotes for
T12274 25423-25426 PRP-DOLLAR- denotes its
T12275 25427-25436 JJ denotes oncogenic
T12276 25437-25445 NN denotes features
T12277 25447-25449 IN denotes In
T12278 25450-25458 JJ denotes multiple
T12279 25459-25466 NN denotes myeloma
T12280 25467-25468 -LRB- denotes (
T12281 25468-25470 NN denotes MM
T12282 25470-25471 -RRB- denotes )
T12283 25472-25473 DT denotes a
T12284 25474-25487 NN denotes translocation
T12285 25488-25490 IN denotes on
T12286 25491-25501 NN denotes chromosome
T12287 25502-25505 NN denotes 14q
T12288 25506-25509 VB denotes was
T12289 25510-25518 VB denotes reported
T12290 25519-25521 TO denotes to
T12291 25522-25526 VB denotes lead
T12292 25527-25529 TO denotes to
T12293 25530-25531 DT denotes a
T12294 25532-25538 NN denotes fusion
T12295 25539-25543 NN denotes gene
T12296 25544-25546 IN denotes of
T12297 25547-25561 NN denotes immunoglobulin
T12298 25562-25573 NN denotes heavy-chain
T12299 25574-25575 -LRB- denotes (
T12300 25575-25578 NN denotes IgH
T12301 25578-25579 -RRB- denotes )
T12302 25580-25583 CC denotes and
T12303 25584-25589 NN denotes IRF-4
T12304 25590-25599 VB denotes resulting
T12305 25600-25602 IN denotes in
T12306 25603-25604 DT denotes a
T12307 25605-25615 JJ denotes subsequent
T12308 25616-25630 NN denotes overexpression
T12309 25631-25633 IN denotes of
T12310 25634-25639 NN denotes IRF-4
T12311 25640-25641 -LRB- denotes (
T12312 25641-25646 CD denotes 48,49
T12313 25646-25647 -RRB- denotes )
T12314 25649-25651 IN denotes In
T12315 25652-25660 NN denotes addition
T12316 25660-25661 -COMMA- denotes ,
T12317 25662-25670 JJ denotes abundant
T12318 25671-25676 NN denotes IRF-4
T12319 25677-25687 NN denotes expression
T12320 25688-25691 VB denotes was
T12321 25692-25697 VB denotes found
T12322 25698-25700 TO denotes to
T12323 25701-25703 VB denotes be
T12324 25704-25705 DT denotes a
T12325 25706-25712 NN denotes marker
T12326 25713-25716 IN denotes for
T12327 25717-25724 JJ denotes various
T12328 25725-25732 NN denotes subsets
T12329 25733-25735 IN denotes of
T12330 25736-25745 NN denotes lymphomas
T12331 25745-25746 -COMMA- denotes ,
T12332 25747-25751 JJ denotes such
T12333 25752-25754 IN denotes as
T12334 25755-25762 JJ denotes diffuse
T12335 25763-25768 JJ denotes large
T12336 25769-25775 NN denotes B-cell
T12337 25776-25785 NN denotes lymphomas
T12338 25785-25786 -COMMA- denotes ,
T12339 25787-25794 JJ denotes primary
T12340 25795-25803 NN denotes effusion
T12341 25804-25812 NN denotes lymphoma
T12342 25812-25813 -COMMA- denotes ,
T12343 25814-25817 CC denotes and
T12344 25818-25826 JJ denotes marginal
T12345 25827-25831 NN denotes zone
T12346 25832-25840 NN denotes lymphoma
T12347 25840-25841 -COMMA- denotes ,
T12348 25842-25845 CC denotes and
T12349 25846-25851 JJ denotes adult
T12350 25852-25858 NN denotes T-cell
T12351 25859-25867 NN denotes leukemia
T12352 25868-25869 -LRB- denotes (
T12353 25869-25880 CD denotes 11,31,50–52
T12354 25880-25881 -RRB- denotes )
T12355 25883-25887 DT denotes This
T12356 25888-25893 VB denotes draws
T12357 25894-25895 DT denotes a
T12358 25896-25900 RB denotes more
T12359 25901-25908 JJ denotes complex
T12360 25909-25916 NN denotes picture
T12361 25917-25919 IN denotes of
T12362 25920-25923 DT denotes the
T12363 25924-25928 NN denotes role
T12364 25929-25931 IN denotes of
T12365 25932-25937 NN denotes IRF-4
T12366 25939-25954 NN denotes Down-regulation
T12367 25955-25957 IN denotes of
T12368 25958-25963 NN denotes IRF-4
T12369 25964-25967 MD denotes may
T12370 25968-25975 VB denotes promote
T12371 25976-25990 NN denotes leukemogenesis
T12372 25991-25993 IN denotes in
T12373 25994-26001 JJ denotes myeloid
T12374 26002-26006 NN denotes cell
T12375 26007-26014 NN denotes context
T12376 26015-26016 -LRB- denotes (
T12377 26016-26017 CD denotes 3
T12378 26017-26018 -RRB- denotes )
T12379 26018-26019 -COMMA- denotes ,
T12380 26020-26025 WDT denotes which
T12381 26026-26029 VB denotes was
T12382 26030-26038 RB denotes recently
T12383 26039-26048 VB denotes confirmed
T12384 26049-26051 IN denotes in
T12385 26052-26060 NN denotes IRF-4−/−
T12386 26061-26069 NN denotes ICSBP−/−
T12387 26070-26076 JJ denotes double
T12388 26077-26086 JJ denotes knock-out
T12389 26087-26091 NN denotes mice
T12390 26092-26093 -LRB- denotes (
T12391 26093-26095 CD denotes 53
T12392 26095-26096 -RRB- denotes )
T12393 26096-26097 -COMMA- denotes ,
T12394 26098-26103 IN denotes while
T12395 26104-26109 NN denotes IRF-4
T12396 26110-26123 NN denotes up-regulation
T12397 26124-26127 MD denotes may
T12398 26128-26134 VB denotes induce
T12399 26135-26136 DT denotes a
T12400 26137-26143 NN denotes growth
T12401 26144-26153 NN denotes advantage
T12402 26154-26156 IN denotes in
T12403 26157-26166 NN denotes lymphomas
T12404 26167-26169 CC denotes or
T12405 26170-26172 NN denotes MM
T12406 26173-26174 -LRB- denotes (
T12407 26174-26176 CD denotes 48
T12408 26176-26177 -RRB- denotes )
T12409 26179-26184 VB denotes Taken
T12410 26185-26193 RB denotes together
T12411 26193-26194 -COMMA- denotes ,
T12412 26195-26198 PRP-DOLLAR- denotes our
T12413 26199-26203 NN denotes data
T12414 26204-26211 VB denotes suggest
T12415 26212-26216 IN denotes that
T12416 26217-26222 NN denotes IRF-4
T12417 26223-26231 NN denotes promoter
T12418 26232-26243 NN denotes methylation
T12419 26244-26253 VB denotes regulates
T12420 26254-26259 NN denotes IRF-4
T12421 26260-26270 NN denotes expression
T12422 26270-26271 -COMMA- denotes ,
T12423 26272-26275 CC denotes and
T12424 26276-26280 IN denotes that
T12425 26281-26289 JJ denotes aberrant
T12426 26290-26300 NN denotes expression
T12427 26301-26303 IN denotes of
T12428 26304-26309 NN denotes IRF-4
T12429 26310-26312 IN denotes in
T12430 26313-26320 JJ denotes certain
T12431 26321-26326 NN denotes types
T12432 26327-26329 IN denotes of
T12433 26330-26338 NN denotes leukemia
T12434 26339-26342 MD denotes may
T12435 26343-26345 VB denotes be
T12436 26346-26347 DT denotes a
T12437 26348-26359 NN denotes consequence
T12438 26360-26362 IN denotes of
T12439 26363-26368 NN denotes IRF-4
T12440 26369-26377 NN denotes promoter
T12441 26378-26394 NN denotes hypermethylation
R1000 T1337 T1334 arg2Of induced,can
R10000 T12099 T12086 arg1Of demonstrated,Indeed
R10001 T12099 T12087 arg1Of demonstrated,","
R10002 T12103 T12099 arg2Of benefit,demonstrated
R10003 T12103 T12100 arg1Of benefit,the
R10004 T12103 T12101 arg1Of benefit,potential
R10005 T12103 T12102 arg1Of benefit,clinical
R10006 T12103 T12104 arg1Of benefit,of
R10007 T12106 T12104 arg2Of treatment,of
R10008 T12106 T12105 arg1Of treatment,a
R10009 T12106 T12107 arg1Of treatment,with
R1001 T1337 T1335 arg1Of induced,not
R10010 T12109 T12107 arg2Of agents,with
R10011 T12109 T12108 arg1Of agents,demethylating
R10012 T12109 T12110 arg1Of agents,(
R10013 T12111 T12110 arg2Of 42–45,(
R10014 T12112 T12110 arg3Of ),(
R10015 T12114 T12113 arg1Of expression,The
R10016 T12114 T12115 arg1Of expression,of
R10017 T12114 T12128 arg1Of expression,is
R10018 T12114 T12129 arg1Of expression,impaired
R10019 T12117 T12116 arg1Of IRF,another
R1002 T1337 T1336 arg2Of induced,be
R10020 T12117 T12118 arg1Of IRF,","
R10021 T12118 T12115 arg2Of ",",of
R10022 T12123 T12118 arg2Of protein,","
R10023 T12123 T12119 arg1Of protein,IFN
R10024 T12123 T12120 arg1Of protein,consensus
R10025 T12123 T12121 arg1Of protein,sequence
R10026 T12123 T12122 arg1Of protein,binding
R10027 T12123 T12124 arg1Of protein,(
R10028 T12125 T12124 arg2Of ICSBP/IRF-8,(
R10029 T12126 T12124 arg3Of ),(
R1003 T1337 T1341 arg1Of induced,but
R10030 T12128 T12127 arg1Of is,","
R10031 T12129 T12128 arg2Of impaired,is
R10032 T12129 T12130 arg1Of impaired,in
R10033 T12134 T12130 arg2Of CML,in
R10034 T12134 T12131 arg1Of CML,myeloid
R10035 T12134 T12132 arg1Of CML,leukemias
R10036 T12134 T12133 arg1Of CML,especially
R10037 T12134 T12135 arg1Of CML,(
R10038 T12136 T12135 arg2Of "27,46,47",(
R10039 T12137 T12135 arg3Of ),(
R1004 T1337 T1342 arg1Of induced,by
R10040 T12140 T12139 arg2Of contrast,in
R10041 T12140 T12141 arg1Of contrast,to
R10042 T12142 T12141 arg2Of IRF-4,to
R10043 T12145 T12144 arg1Of loss,the
R10044 T12145 T12146 arg1Of loss,of
R10045 T12145 T12149 arg1Of loss,could
R10046 T12145 T12151 arg1Of loss,be
R10047 T12145 T12152 arg2Of loss,reverted
R10048 T12148 T12146 arg2Of IRF,of
R10049 T12148 T12147 arg1Of IRF,this
R1005 T1339 T1337 arg1Of IFNs,induced
R10050 T12152 T12149 arg2Of reverted,could
R10051 T12152 T12150 arg1Of reverted,not
R10052 T12152 T12151 arg2Of reverted,be
R10053 T12152 T12153 arg1Of reverted,in
R10054 T12152 T12166 arg1Of reverted,by
R10055 T12152 T12174 arg1Of reverted,and
R10056 T12156 T12153 arg2Of lines,in
R10057 T12156 T12154 arg1Of lines,ICSBP-negative
R10058 T12156 T12155 arg1Of lines,cell
R10059 T12156 T12157 arg1Of lines,(
R1006 T1339 T1338 arg2Of IFNs,by
R10060 T12158 T12159 arg1Of EM-2,","
R10061 T12159 T12161 arg1Of ",",","
R10062 T12160 T12159 arg2Of CML-T1,","
R10063 T12161 T12163 arg1Of ",",and
R10064 T12162 T12161 arg2Of K-562,","
R10065 T12163 T12157 arg2Of and,(
R10066 T12164 T12163 arg2Of LAMA-84,and
R10067 T12165 T12157 arg3Of ),(
R10068 T12167 T12166 arg2Of treatment,by
R10069 T12167 T12168 arg1Of treatment,with
R1007 T1341 T1340 arg1Of but,","
R10070 T12169 T12168 arg2Of AzadC,with
R10071 T12169 T12170 arg1Of AzadC,(
R10072 T12171 T12170 arg2Of Figure,(
R10073 T12171 T12172 arg1Of Figure,6
R10074 T12173 T12170 arg3Of ),(
R10075 T12174 T12138 arg1Of and,But
R10076 T12174 T12139 arg1Of and,in
R10077 T12174 T12143 arg1Of and,","
R10078 T12175 T12176 arg1Of AzadC,has
R10079 T12176 T12174 arg2Of has,and
R1008 T1344 T1343 arg1Of stimulation,antigen
R10080 T12176 T12179 arg1Of has,on
R10081 T12178 T12176 arg2Of effect,has
R10082 T12178 T12177 arg1Of effect,no
R10083 T12181 T12179 arg2Of levels,on
R10084 T12181 T12180 arg1Of levels,ICSBP
R10085 T12181 T12182 arg1Of levels,in
R10086 T12185 T12182 arg2Of cells,in
R10087 T12185 T12183 arg1Of cells,ICSBP-positive
R10088 T12185 T12184 arg1Of cells,U-937
R10089 T12185 T12186 arg1Of cells,(
R1009 T1344 T1345 arg1Of stimulation,","
R10090 T12187 T12186 arg2Of Figure,(
R10091 T12187 T12188 arg1Of Figure,6
R10092 T12189 T12186 arg3Of ),(
R10093 T12191 T12190 arg1Of data,These
R10094 T12191 T12192 arg1Of data,suggest
R10095 T12196 T12192 arg2Of mechanism,suggest
R10096 T12196 T12193 arg1Of mechanism,a
R10097 T12196 T12194 arg1Of mechanism,distinct
R10098 T12196 T12195 arg1Of mechanism,regulatory
R10099 T12196 T12197 arg1Of mechanism,for
R1010 T1345 T1352 arg1Of ",",or
R10100 T12200 T12197 arg2Of IRFs,for
R10101 T12200 T12198 arg1Of IRFs,these
R10102 T12200 T12199 arg1Of IRFs,two
R10103 T12201 T12202 arg1Of IRF-4,","
R10104 T12201 T12203 arg1Of IRF-4,similar
R10105 T12203 T12204 arg1Of similar,to
R10106 T12210 T12204 arg2Of genes,to
R10107 T12210 T12205 arg1Of genes,many
R10108 T12210 T12206 arg1Of genes,other
R10109 T12210 T12207 arg1Of genes,classical
R1011 T1346 T1345 arg2Of crosslinking,","
R10110 T12210 T12208 arg1Of genes,tumor
R10111 T12210 T12209 arg1Of genes,suppressor
R10112 T12211 T12212 arg1Of p15INK4b,","
R10113 T12212 T12214 arg1Of ",",or
R10114 T12213 T12212 arg2Of p16INK4a,","
R10115 T12214 T12201 arg1Of or,IRF-4
R10116 T12214 T12217 arg1Of or,may
R10117 T12214 T12219 arg1Of or,be
R10118 T12215 T12214 arg2Of p53,or
R10119 T12219 T12216 arg1Of be,","
R1012 T1346 T1347 arg1Of crosslinking,of
R10120 T12219 T12217 arg2Of be,may
R10121 T12219 T12218 arg1Of be,thus
R10122 T12221 T12219 arg2Of subject,be
R10123 T12221 T12220 arg1Of subject,a
R10124 T12221 T12222 arg1Of subject,of
R10125 T12221 T12224 arg1Of subject,in
R10126 T12221 T12233 arg1Of subject,","
R10127 T12221 T12234 arg1Of subject,which
R10128 T12221 T12235 arg1Of subject,might
R10129 T12221 T12236 arg1Of subject,contribute
R1013 T1348 T1349 arg1Of T-,or
R10130 T12223 T12222 arg2Of alterations,of
R10131 T12228 T12224 arg2Of status,in
R10132 T12228 T12225 arg1Of status,the
R10133 T12228 T12226 arg1Of status,promoter
R10134 T12228 T12227 arg1Of status,methylation
R10135 T12228 T12229 arg1Of status,leading
R10136 T12229 T12230 arg1Of leading,to
R10137 T12232 T12230 arg2Of changes,to
R10138 T12232 T12231 arg1Of changes,expression
R10139 T12236 T12235 arg2Of contribute,might
R1014 T1350 T1349 arg2Of B-cell,or
R10140 T12236 T12237 arg1Of contribute,to
R10141 T12239 T12240 arg1Of initiation,and/or
R10142 T12240 T12237 arg2Of and/or,to
R10143 T12240 T12238 arg1Of and/or,the
R10144 T12240 T12242 arg1Of and/or,of
R10145 T12241 T12240 arg2Of progression,and/or
R10146 T12243 T12242 arg2Of cancer,of
R10147 T12249 T12246 arg1Of diversity,the
R10148 T12249 T12247 arg1Of diversity,obvious
R10149 T12249 T12248 arg1Of diversity,functional
R1015 T1351 T1347 arg2Of receptors,of
R10150 T12249 T12250 arg1Of diversity,of
R10151 T12249 T12252 arg1Of diversity,remains
R10152 T12249 T12253 arg1Of diversity,remarkable
R10153 T12249 T12255 arg1Of diversity,can
R10154 T12249 T12257 arg1Of diversity,be
R10155 T12249 T12259 arg2Of diversity,explained
R10156 T12251 T12250 arg2Of IRF-4,of
R10157 T12252 T12254 arg1Of remains,and
R10158 T12253 T12252 arg2Of remarkable,remains
R10159 T12254 T12244 arg1Of and,Still
R1016 T1351 T1348 arg1Of receptors,T-
R10160 T12254 T12245 arg1Of and,","
R10161 T12259 T12254 arg2Of explained,and
R10162 T12259 T12255 arg2Of explained,can
R10163 T12259 T12256 arg1Of explained,not
R10164 T12259 T12257 arg2Of explained,be
R10165 T12259 T12258 arg1Of explained,fully
R10166 T12265 T12259 arg1Of status,explained
R10167 T12265 T12260 arg2Of status,by
R10168 T12265 T12261 arg1Of status,the
R10169 T12265 T12262 arg1Of status,IRF-4
R1017 T1351 T1350 arg1Of receptors,B-cell
R10170 T12265 T12263 arg1Of status,promoter
R10171 T12265 T12264 arg1Of status,methylation
R10172 T12267 T12266 arg2Of example,For
R10173 T12269 T12270 arg1Of IRF-4,is
R10174 T12269 T12272 arg2Of IRF-4,known
R10175 T12272 T12266 arg1Of known,For
R10176 T12272 T12268 arg1Of known,","
R10177 T12272 T12270 arg2Of known,is
R10178 T12272 T12271 arg1Of known,primarily
R10179 T12272 T12273 arg1Of known,for
R1018 T1352 T1342 arg2Of or,by
R10180 T12276 T12273 arg2Of features,for
R10181 T12276 T12274 arg1Of features,its
R10182 T12276 T12275 arg1Of features,oncogenic
R10183 T12279 T12277 arg2Of myeloma,In
R10184 T12279 T12278 arg1Of myeloma,multiple
R10185 T12279 T12280 arg1Of myeloma,(
R10186 T12281 T12280 arg2Of MM,(
R10187 T12282 T12280 arg3Of ),(
R10188 T12284 T12283 arg1Of translocation,a
R10189 T12284 T12285 arg1Of translocation,on
R1019 T1353 T1352 arg2Of phorbol-myristate-acetate,or
R10190 T12284 T12288 arg1Of translocation,was
R10191 T12284 T12289 arg2Of translocation,reported
R10192 T12284 T12291 arg1Of translocation,lead
R10193 T12287 T12285 arg2Of 14q,on
R10194 T12287 T12286 arg1Of 14q,chromosome
R10195 T12289 T12277 arg1Of reported,In
R10196 T12289 T12288 arg2Of reported,was
R10197 T12289 T12304 modOf reported,resulting
R10198 T12291 T12289 arg3Of lead,reported
R10199 T12291 T12290 arg1Of lead,to
R1020 T1353 T1354 arg1Of phorbol-myristate-acetate,(
R10200 T12291 T12292 arg1Of lead,to
R10201 T12295 T12292 arg2Of gene,to
R10202 T12295 T12293 arg1Of gene,a
R10203 T12295 T12294 arg1Of gene,fusion
R10204 T12295 T12296 arg1Of gene,of
R10205 T12298 T12297 arg1Of heavy-chain,immunoglobulin
R10206 T12298 T12299 arg1Of heavy-chain,(
R10207 T12298 T12302 arg1Of heavy-chain,and
R10208 T12300 T12299 arg2Of IgH,(
R10209 T12301 T12299 arg3Of ),(
R1021 T1355 T1354 arg2Of "10,11",(
R10210 T12302 T12296 arg2Of and,of
R10211 T12303 T12302 arg2Of IRF-4,and
R10212 T12304 T12305 arg1Of resulting,in
R10213 T12308 T12305 arg2Of overexpression,in
R10214 T12308 T12306 arg1Of overexpression,a
R10215 T12308 T12307 arg1Of overexpression,subsequent
R10216 T12308 T12309 arg1Of overexpression,of
R10217 T12310 T12309 arg2Of IRF-4,of
R10218 T12310 T12311 arg1Of IRF-4,(
R10219 T12312 T12311 arg2Of "48,49",(
R1022 T1356 T1354 arg3Of ),(
R10220 T12313 T12311 arg3Of ),(
R10221 T12315 T12314 arg2Of addition,In
R10222 T12319 T12317 arg1Of expression,abundant
R10223 T12319 T12318 arg1Of expression,IRF-4
R10224 T12319 T12320 arg1Of expression,was
R10225 T12319 T12321 arg2Of expression,found
R10226 T12319 T12323 arg1Of expression,be
R10227 T12321 T12314 arg1Of found,In
R10228 T12321 T12316 arg1Of found,","
R10229 T12321 T12320 arg2Of found,was
R1023 T1357 T1358 arg1Of Consistent,with
R10230 T12323 T12321 arg3Of be,found
R10231 T12323 T12322 arg1Of be,to
R10232 T12325 T12323 arg2Of marker,be
R10233 T12325 T12324 arg1Of marker,a
R10234 T12325 T12326 arg1Of marker,for
R10235 T12328 T12326 arg2Of subsets,for
R10236 T12328 T12327 arg1Of subsets,various
R10237 T12328 T12329 arg1Of subsets,of
R10238 T12328 T12331 arg1Of subsets,","
R10239 T12328 T12333 arg1Of subsets,as
R1024 T1360 T1358 arg2Of restriction,with
R10240 T12330 T12329 arg2Of lymphomas,of
R10241 T12333 T12332 arg1Of as,such
R10242 T12337 T12334 arg1Of lymphomas,diffuse
R10243 T12337 T12335 arg1Of lymphomas,large
R10244 T12337 T12336 arg1Of lymphomas,B-cell
R10245 T12337 T12338 arg1Of lymphomas,","
R10246 T12338 T12343 arg1Of ",",and
R10247 T12341 T12338 arg2Of lymphoma,","
R10248 T12341 T12339 arg1Of lymphoma,primary
R10249 T12341 T12340 arg1Of lymphoma,effusion
R1025 T1360 T1359 arg1Of restriction,the
R10250 T12343 T12342 arg1Of and,","
R10251 T12343 T12348 arg1Of and,and
R10252 T12346 T12343 arg2Of lymphoma,and
R10253 T12346 T12344 arg1Of lymphoma,marginal
R10254 T12346 T12345 arg1Of lymphoma,zone
R10255 T12348 T12333 arg2Of and,as
R10256 T12348 T12347 arg1Of and,","
R10257 T12351 T12348 arg2Of leukemia,and
R10258 T12351 T12349 arg1Of leukemia,adult
R10259 T12351 T12350 arg1Of leukemia,T-cell
R1026 T1360 T1361 arg1Of restriction,of
R10260 T12351 T12352 arg1Of leukemia,(
R10261 T12353 T12352 arg2Of "11,31,50–52",(
R10262 T12354 T12352 arg3Of ),(
R10263 T12355 T12356 arg1Of This,draws
R10264 T12359 T12358 arg1Of complex,more
R10265 T12360 T12356 arg2Of picture,draws
R10266 T12360 T12357 arg1Of picture,a
R10267 T12360 T12359 arg1Of picture,complex
R10268 T12360 T12361 arg1Of picture,of
R10269 T12363 T12361 arg2Of role,of
R1027 T1360 T1363 arg1Of restriction,to
R10270 T12363 T12362 arg1Of role,the
R10271 T12363 T12364 arg1Of role,of
R10272 T12365 T12364 arg2Of IRF-4,of
R10273 T12366 T12367 arg1Of Down-regulation,of
R10274 T12366 T12369 arg1Of Down-regulation,may
R10275 T12366 T12370 arg1Of Down-regulation,promote
R10276 T12368 T12367 arg2Of IRF-4,of
R10277 T12370 T12369 arg2Of promote,may
R10278 T12370 T12372 arg1Of promote,in
R10279 T12371 T12370 arg2Of leukemogenesis,promote
R1028 T1362 T1361 arg2Of expression,of
R10280 T12375 T12372 arg2Of context,in
R10281 T12375 T12373 arg1Of context,myeloid
R10282 T12375 T12374 arg1Of context,cell
R10283 T12375 T12376 arg1Of context,(
R10284 T12375 T12379 arg1Of context,","
R10285 T12375 T12380 arg1Of context,which
R10286 T12375 T12381 arg1Of context,was
R10287 T12375 T12383 arg2Of context,confirmed
R10288 T12377 T12376 arg2Of 3,(
R10289 T12378 T12376 arg3Of ),(
R1029 T1365 T1363 arg2Of cells,to
R10290 T12383 T12381 arg2Of confirmed,was
R10291 T12383 T12382 arg1Of confirmed,recently
R10292 T12383 T12384 arg1Of confirmed,in
R10293 T12383 T12393 arg1Of confirmed,","
R10294 T12383 T12394 arg1Of confirmed,while
R10295 T12389 T12384 arg2Of mice,in
R10296 T12389 T12385 arg1Of mice,IRF-4−/−
R10297 T12389 T12386 arg1Of mice,ICSBP−/−
R10298 T12389 T12387 arg1Of mice,double
R10299 T12389 T12388 arg1Of mice,knock-out
R1030 T1365 T1364 arg1Of cells,immunocompetent
R10300 T12389 T12390 arg1Of mice,(
R10301 T12391 T12390 arg2Of 53,(
R10302 T12392 T12390 arg3Of ),(
R10303 T12396 T12395 arg1Of up-regulation,IRF-4
R10304 T12396 T12397 arg1Of up-regulation,may
R10305 T12396 T12398 arg1Of up-regulation,induce
R10306 T12398 T12394 arg2Of induce,while
R10307 T12398 T12397 arg2Of induce,may
R10308 T12398 T12402 arg1Of induce,in
R10309 T12401 T12398 arg2Of advantage,induce
R1031 T1367 T1368 arg1Of mice,with
R10310 T12401 T12399 arg1Of advantage,a
R10311 T12401 T12400 arg1Of advantage,growth
R10312 T12403 T12404 arg1Of lymphomas,or
R10313 T12404 T12402 arg2Of or,in
R10314 T12405 T12404 arg2Of MM,or
R10315 T12405 T12406 arg1Of MM,(
R10316 T12407 T12406 arg2Of 48,(
R10317 T12408 T12406 arg3Of ),(
R10318 T12409 T12410 arg1Of Taken,together
R10319 T12413 T12412 arg1Of data,our
R1032 T1367 T1372 arg1Of mice,failed
R10320 T12413 T12414 arg1Of data,suggest
R10321 T12414 T12409 modOf suggest,Taken
R10322 T12414 T12411 arg1Of suggest,","
R10323 T12418 T12416 arg1Of methylation,IRF-4
R10324 T12418 T12417 arg1Of methylation,promoter
R10325 T12418 T12419 arg1Of methylation,regulates
R10326 T12419 T12415 arg1Of regulates,that
R10327 T12419 T12423 arg1Of regulates,and
R10328 T12421 T12419 arg2Of expression,regulates
R10329 T12421 T12420 arg1Of expression,IRF-4
R1033 T1367 T1374 arg1Of mice,develop
R10330 T12423 T12414 arg2Of and,suggest
R10331 T12423 T12422 arg1Of and,","
R10332 T12424 T12423 arg2Of that,and
R10333 T12426 T12425 arg1Of expression,aberrant
R10334 T12426 T12427 arg1Of expression,of
R10335 T12426 T12429 arg1Of expression,in
R10336 T12426 T12434 arg1Of expression,may
R10337 T12426 T12435 arg1Of expression,be
R10338 T12428 T12427 arg2Of IRF-4,of
R10339 T12431 T12429 arg2Of types,in
R1034 T1369 T1368 arg2Of deletion,with
R10340 T12431 T12430 arg1Of types,certain
R10341 T12431 T12432 arg1Of types,of
R10342 T12433 T12432 arg2Of leukemia,of
R10343 T12435 T12424 arg2Of be,that
R10344 T12435 T12434 arg2Of be,may
R10345 T12437 T12435 arg2Of consequence,be
R10346 T12437 T12436 arg1Of consequence,a
R10347 T12437 T12438 arg1Of consequence,of
R10348 T12441 T12438 arg2Of hypermethylation,of
R10349 T12441 T12439 arg1Of hypermethylation,IRF-4
R1035 T1369 T1370 arg1Of deletion,of
R10350 T12441 T12440 arg1Of hypermethylation,promoter
R1036 T1371 T1370 arg2Of IRF-4,of
R1037 T1372 T1386 arg1Of failed,and
R1038 T1374 T1372 arg2Of develop,failed
R1039 T1374 T1373 arg1Of develop,to
R1040 T1375 T1376 arg1Of mature,and
R1041 T1378 T1376 arg2Of active,and
R1042 T1378 T1377 arg1Of active,functionally
R1043 T1379 T1375 arg1Of B-,mature
R1044 T1379 T1378 arg1Of B-,active
R1045 T1379 T1380 arg1Of B-,and
R1046 T1380 T1374 arg2Of and,develop
R1047 T1381 T1380 arg2Of T-lymphocytes,and
R1048 T1381 T1382 arg1Of T-lymphocytes,(
R1049 T1383 T1382 arg2Of 12,(
R1050 T1384 T1382 arg3Of ),(
R1051 T1386 T1357 arg1Of and,Consistent
R1052 T1386 T1366 arg1Of and,","
R1053 T1386 T1385 arg1Of and,","
R1054 T1389 T1387 arg1Of expression,the
R1055 T1389 T1388 arg1Of expression,impaired
R1056 T1389 T1390 arg1Of expression,of
R1057 T1389 T1392 arg1Of expression,in
R1058 T1389 T1394 arg1Of expression,was
R1059 T1389 T1396 arg2Of expression,found
R1060 T1391 T1390 arg2Of IRF-4,of
R1061 T1393 T1392 arg2Of CML,in
R1062 T1396 T1386 arg2Of found,and
R1063 T1396 T1394 arg2Of found,was
R1064 T1396 T1395 arg1Of found,predominately
R1065 T1396 T1397 arg1Of found,in
R1066 T1398 T1397 arg2Of T-cells,in
R1067 T1398 T1399 arg1Of T-cells,(
R1068 T1400 T1399 arg2Of 3,(
R1069 T1401 T1399 arg3Of ),(
R1070 T1403 T1402 arg1Of data,These
R1071 T1403 T1404 arg1Of data,suggest
R1072 T1407 T1404 arg2Of role,suggest
R1073 T1407 T1405 arg1Of role,a
R1074 T1407 T1406 arg1Of role,crucial
R1075 T1407 T1408 arg1Of role,for
R1076 T1407 T1410 arg1Of role,in
R1077 T1409 T1408 arg2Of IRF-4,for
R1078 T1412 T1410 arg2Of function,in
R1079 T1412 T1411 arg1Of function,the
R1080 T1412 T1413 arg1Of function,of
R1081 T1415 T1413 arg2Of cells,of
R1082 T1415 T1414 arg1Of cells,immune
R1083 T1416 T1417 arg1Of Methylation,of
R1084 T1416 T1424 arg1Of Methylation,","
R1085 T1416 T1426 arg1Of Methylation,in
R1086 T1416 T1434 arg1Of Methylation,is
R1087 T1420 T1417 arg2Of motifs,of
R1088 T1420 T1418 arg1Of motifs,dinucleotide
R1089 T1420 T1419 arg1Of motifs,cytosine-guanosine
R1090 T1420 T1421 arg1Of motifs,(
R1091 T1422 T1421 arg2Of CpG,(
R1092 T1423 T1421 arg3Of ),(
R1093 T1426 T1425 arg1Of in,especially
R1094 T1428 T1426 arg2Of islands,in
R1095 T1428 T1427 arg1Of islands,CpG
R1096 T1428 T1429 arg2Of islands,located
R1097 T1429 T1430 arg1Of located,in
R1098 T1432 T1430 arg2Of regions,in
R1099 T1432 T1431 arg1Of regions,promoter
R1100 T1434 T1433 arg1Of is,","
R1101 T1435 T1436 arg1Of one,of
R1102 T1435 T1444 arg1Of one,and
R1103 T1438 T1436 arg2Of mechanisms,of
R1104 T1438 T1437 arg1Of mechanisms,the
R1105 T1438 T1439 arg1Of mechanisms,of
R1106 T1438 T1442 arg1Of mechanisms,in
R1107 T1441 T1439 arg2Of regulation,of
R1108 T1441 T1440 arg1Of regulation,gene
R1109 T1443 T1442 arg2Of mammals,in
R1110 T1444 T1434 arg2Of and,is
R1111 T1447 T1444 arg2Of event,and
R1112 T1447 T1445 arg1Of event,a
R1113 T1447 T1446 arg1Of event,common
R1114 T1447 T1448 arg1Of event,of
R1115 T1447 T1451 arg1Of event,in
R1116 T1450 T1448 arg2Of silencing,of
R1117 T1450 T1449 arg1Of silencing,gene
R1118 T1453 T1451 arg2Of neoplasias,in
R1119 T1453 T1452 arg1Of neoplasias,human
R1120 T1453 T1454 arg1Of neoplasias,(
R1121 T1455 T1454 arg2Of "13,14",(
R1122 T1456 T1454 arg3Of ),(
R1123 T1458 T1457 arg2Of opposed,As
R1124 T1458 T1459 arg1Of opposed,to
R1125 T1461 T1459 arg2Of cells,to
R1126 T1461 T1460 arg1Of cells,normal
R1127 T1463 T1464 arg1Of hypermethylation,of
R1128 T1463 T1467 arg1Of hypermethylation,is
R1129 T1466 T1464 arg2Of islands,of
R1130 T1466 T1465 arg1Of islands,CpG
R1131 T1467 T1457 arg1Of is,As
R1132 T1467 T1462 arg1Of is,","
R1133 T1467 T1472 arg1Of is,in
R1134 T1470 T1469 arg1Of observed,frequently
R1135 T1471 T1467 arg2Of phenomenon,is
R1136 T1471 T1468 arg1Of phenomenon,a
R1137 T1471 T1470 arg1Of phenomenon,observed
R1138 T1475 T1472 arg2Of type,in
R1139 T1475 T1473 arg1Of type,every
R1140 T1475 T1474 arg1Of type,cancer
R1141 T1477 T1476 arg1Of novo,De
R1142 T1479 T1477 arg1Of methylation,novo
R1143 T1479 T1478 arg1Of methylation,DNA
R1144 T1479 T1480 arg1Of methylation,of
R1145 T1479 T1495 arg1Of methylation,is
R1146 T1479 T1497 arg2Of methylation,thought
R1147 T1479 T1499 arg1Of methylation,be
R1148 T1479 T1500 arg2Of methylation,involved
R1149 T1481 T1480 arg2Of genes,of
R1150 T1481 T1483 arg1Of genes,as
R1151 T1483 T1482 arg1Of as,such
R1152 T1485 T1484 arg1Of cycle,cell
R1153 T1485 T1486 arg1Of cycle,","
R1154 T1486 T1489 arg1Of ",",","
R1155 T1488 T1486 arg2Of repair,","
R1156 T1488 T1487 arg1Of repair,DNA
R1157 T1489 T1491 arg1Of ",",and
R1158 T1490 T1489 arg2Of apoptosis,","
R1159 T1491 T1483 arg2Of and,as
R1160 T1494 T1491 arg2Of genes,and
R1161 T1494 T1492 arg1Of genes,tumor
R1162 T1494 T1493 arg1Of genes,suppressor
R1163 T1497 T1495 arg2Of thought,is
R1164 T1497 T1496 arg1Of thought,therefore
R1165 T1500 T1497 arg3Of involved,thought
R1166 T1500 T1498 arg1Of involved,to
R1167 T1500 T1499 arg2Of involved,be
R1168 T1500 T1501 arg1Of involved,in
R1169 T1502 T1501 arg2Of tumorigenesis,in
R1170 T1502 T1503 arg1Of tumorigenesis,(
R1171 T1504 T1503 arg2Of 15–17,(
R1172 T1505 T1503 arg3Of ),(
R1173 T1506 T1507 arg1Of Examples,for
R1174 T1506 T1511 arg1Of Examples,are
R1175 T1509 T1508 arg1Of aberrated,such
R1176 T1510 T1507 arg2Of genes,for
R1177 T1510 T1509 arg1Of genes,aberrated
R1178 T1512 T1513 arg1Of MGMT,","
R1179 T1513 T1515 arg1Of ",",","
R1180 T1514 T1513 arg2Of DAPK,","
R1181 T1515 T1517 arg1Of ",",","
R1182 T1516 T1515 arg2Of p14ARF,","
R1183 T1517 T1519 arg1Of ",",","
R1184 T1518 T1517 arg2Of p15INK4b,","
R1185 T1519 T1521 arg1Of ",",","
R1186 T1520 T1519 arg2Of p16INK4a,","
R1187 T1521 T1523 arg1Of ",",","
R1188 T1522 T1521 arg2Of BRCA1,","
R1189 T1523 T1525 arg1Of ",",and
R1190 T1524 T1523 arg2Of CDH13,","
R1191 T1525 T1511 arg2Of and,are
R1192 T1526 T1525 arg2Of APAF-1,and
R1193 T1526 T1527 arg1Of APAF-1,(
R1194 T1528 T1527 arg2Of 17–19,(
R1195 T1529 T1527 arg3Of ),(
R1196 T1531 T1530 arg2Of CML,In
R1197 T1533 T1534 arg1Of methylation,is
R1198 T1533 T1535 arg2Of methylation,known
R1199 T1533 T1537 arg1Of methylation,regulate
R1200 T1535 T1534 arg2Of known,is
R1201 T1535 T1552 arg1Of known,and
R1202 T1537 T1535 arg3Of regulate,known
R1203 T1537 T1536 arg1Of regulate,to
R1204 T1538 T1537 arg2Of expression,regulate
R1205 T1538 T1539 arg1Of expression,of
R1206 T1541 T1540 arg1Of c-abl,the
R1207 T1541 T1542 arg1Of c-abl,","
R1208 T1542 T1546 arg1Of ",",and
R1209 T1545 T1542 arg2Of gene,","
R1210 T1545 T1543 arg1Of gene,the
R1211 T1545 T1544 arg1Of gene,bcr
R1212 T1546 T1539 arg2Of and,of
R1213 T1547 T1546 arg2Of others,and
R1214 T1547 T1548 arg1Of others,(
R1215 T1549 T1548 arg2Of 20–23,(
R1216 T1550 T1548 arg3Of ),(
R1217 T1552 T1530 arg1Of and,In
R1218 T1552 T1532 arg1Of and,","
R1219 T1552 T1551 arg1Of and,","
R1220 T1554 T1553 arg1Of extent,the
R1221 T1554 T1555 arg1Of extent,of
R1222 T1554 T1557 arg1Of extent,in
R1223 T1554 T1561 arg1Of extent,has
R1224 T1554 T1562 arg1Of extent,been
R1225 T1554 T1563 arg2Of extent,shown
R1226 T1554 T1565 arg1Of extent,be
R1227 T1554 T1566 arg2Of extent,associated
R1228 T1556 T1555 arg2Of methylation,of
R1229 T1560 T1557 arg2Of promoter,in
R1230 T1560 T1558 arg1Of promoter,the
R1231 T1560 T1559 arg1Of promoter,c-abl
R1232 T1563 T1552 arg2Of shown,and
R1233 T1563 T1561 arg2Of shown,has
R1234 T1563 T1562 arg2Of shown,been
R1235 T1566 T1563 arg3Of associated,shown
R1236 T1566 T1564 arg1Of associated,to
R1237 T1566 T1565 arg2Of associated,be
R1238 T1566 T1567 arg1Of associated,with
R1239 T1569 T1567 arg2Of disease,with
R1240 T1569 T1568 arg2Of disease,advanced
R1241 T1569 T1570 arg1Of disease,(
R1242 T1571 T1570 arg2Of 24,(
R1243 T1572 T1570 arg3Of ),(
R1244 T1573 T1574 arg1Of Hypermethylation,due
R1245 T1573 T1583 arg1Of Hypermethylation,remains
R1246 T1574 T1575 arg1Of due,to
R1247 T1576 T1574 arg2Of overexpression,due
R1248 T1576 T1577 arg1Of overexpression,of
R1249 T1576 T1580 arg1Of overexpression,(
R1250 T1579 T1577 arg2Of methyltransferases,of
R1251 T1579 T1578 arg1Of methyltransferases,DNA
R1252 T1581 T1580 arg2Of DNMTs,(
R1253 T1582 T1580 arg3Of ),(
R1254 T1586 T1583 arg2Of explanation,remains
R1255 T1586 T1584 arg1Of explanation,one
R1256 T1586 T1585 arg1Of explanation,possible
R1257 T1586 T1587 arg1Of explanation,for
R1258 T1589 T1588 arg1Of novo,de
R1259 T1590 T1587 arg2Of methylation,for
R1260 T1590 T1589 arg1Of methylation,novo
R1261 T1590 T1591 arg1Of methylation,in
R1262 T1592 T1591 arg2Of tumorigenesis,in
R1263 T1595 T1596 arg1Of DNMTs,have
R1264 T1595 T1597 arg1Of DNMTs,been
R1265 T1595 T1598 arg2Of DNMTs,shown
R1266 T1595 T1600 arg1Of DNMTs,be
R1267 T1595 T1601 arg2Of DNMTs,up-regulated
R1268 T1598 T1593 arg1Of shown,Recently
R1269 T1598 T1594 arg1Of shown,","
R1270 T1598 T1596 arg2Of shown,have
R1271 T1598 T1597 arg2Of shown,been
R1272 T1601 T1598 arg3Of up-regulated,shown
R1273 T1601 T1599 arg1Of up-regulated,to
R1274 T1601 T1600 arg2Of up-regulated,be
R1275 T1601 T1602 arg1Of up-regulated,in
R1276 T1604 T1602 arg2Of malignancies,in
R1277 T1604 T1603 arg1Of malignancies,hematopoietic
R1278 T1604 T1605 arg1Of malignancies,(
R1279 T1606 T1605 arg2Of 25,(
R1280 T1607 T1605 arg3Of ),(
R1281 T1609 T1608 arg1Of proteins,Methyl-CpG-binding
R1282 T1609 T1610 arg1Of proteins,(
R1283 T1609 T1613 arg1Of proteins,are
R1284 T1609 T1614 arg2Of proteins,thought
R1285 T1609 T1616 arg1Of proteins,inhibit
R1286 T1609 T1626 arg1Of proteins,are
R1287 T1609 T1628 arg2Of proteins,discussed
R1288 T1611 T1610 arg2Of MBPs,(
R1289 T1612 T1610 arg3Of ),(
R1290 T1614 T1613 arg2Of thought,are
R1291 T1614 T1625 arg1Of thought,and
R1292 T1616 T1614 arg3Of inhibit,thought
R1293 T1616 T1615 arg1Of inhibit,to
R1294 T1618 T1616 arg2Of binding,inhibit
R1295 T1618 T1617 arg1Of binding,the
R1296 T1618 T1619 arg1Of binding,of
R1297 T1618 T1622 arg1Of binding,to
R1298 T1621 T1619 arg2Of factors,of
R1299 T1621 T1620 arg1Of factors,transcriptional
R1300 T1624 T1622 arg2Of promoter,to
R1301 T1624 T1623 arg1Of promoter,the
R1302 T1628 T1625 arg2Of discussed,and
R1303 T1628 T1626 arg2Of discussed,are
R1304 T1628 T1627 arg1Of discussed,therefore
R1305 T1628 T1629 arg1Of discussed,as
R1306 T1631 T1629 arg2Of mechanism,as
R1307 T1631 T1630 arg1Of mechanism,one
R1308 T1631 T1632 arg1Of mechanism,of
R1309 T1631 T1635 arg1Of mechanism,by
R1310 T1634 T1632 arg2Of inhibition,of
R1311 T1634 T1633 arg1Of inhibition,transcription
R1312 T1636 T1635 arg2Of hypermethylation,by
R1313 T1636 T1637 arg1Of hypermethylation,(
R1314 T1638 T1637 arg2Of 26,(
R1315 T1639 T1637 arg3Of ),(
R1316 T1642 T1640 arg2Of work,In
R1317 T1642 T1641 arg1Of work,this
R1318 T1644 T1645 arg1Of we,studied
R1319 T1645 T1640 arg1Of studied,In
R1320 T1645 T1643 arg1Of studied,","
R1321 T1645 T1652 arg1Of studied,in
R1322 T1646 T1645 arg2Of mechanisms,studied
R1323 T1646 T1647 arg1Of mechanisms,of
R1324 T1651 T1647 arg2Of silencing,of
R1325 T1651 T1648 arg1Of silencing,IRF-4
R1326 T1651 T1649 arg1Of silencing,gene
R1327 T1651 T1650 arg1Of silencing,expression
R1328 T1654 T1652 arg2Of cells,in
R1329 T1654 T1653 arg1Of cells,leukemic
R1330 T1655 T1656 arg1Of We,analyzed
R1331 T1656 T1661 arg1Of analyzed,for
R1332 T1660 T1656 arg2Of region,analyzed
R1333 T1660 T1657 arg1Of region,the
R1334 T1660 T1658 arg1Of region,IRF-4
R1335 T1660 T1659 arg1Of region,promoter
R1336 T1663 T1662 arg1Of aberrations,genetic
R1337 T1663 T1664 arg1Of aberrations,and
R1338 T1664 T1661 arg2Of and,for
R1339 T1664 T1667 arg1Of and,in
R1340 T1666 T1664 arg2Of status,and
R1341 T1666 T1665 arg1Of status,methylational
R1342 T1668 T1669 arg1Of IRF-4-positive,and
R1343 T1670 T1669 arg2Of -negative,and
R1344 T1672 T1667 arg2Of cells,in
R1345 T1672 T1668 arg1Of cells,IRF-4-positive
R1346 T1672 T1670 arg1Of cells,-negative
R1347 T1672 T1671 arg1Of cells,hematopoietic
R2131 T2711 T2710 arg1Of lines,Cell
R2132 T2712 T2713 arg1Of K-562,","
R2133 T2713 T2715 arg1Of ",",and
R2134 T2714 T2713 arg2Of Jurkat,","
R2135 T2715 T2717 arg1Of and,were
R2136 T2715 T2718 arg2Of and,obtained
R2137 T2716 T2715 arg2Of U-937,and
R2138 T2718 T2717 arg2Of obtained,were
R2139 T2718 T2719 arg1Of obtained,from
R2140 T2718 T2742 arg1Of obtained,and
R2141 T2721 T2722 arg1Of ATCC,(
R2142 T2721 T2732 arg1Of ATCC,and
R2143 T2726 T2722 arg2Of Collection,(
R2144 T2726 T2723 arg1Of Collection,American
R2145 T2726 T2724 arg1Of Collection,Type
R2146 T2726 T2725 arg1Of Collection,Culture
R2147 T2726 T2727 arg1Of Collection,","
R2148 T2728 T2727 arg2Of Rockville,","
R2149 T2728 T2729 arg1Of Rockville,","
R2150 T2730 T2729 arg2Of USA,","
R2151 T2731 T2722 arg3Of ),(
R2152 T2732 T2719 arg2Of and,from
R2153 T2732 T2720 arg1Of and,the
R2154 T2733 T2734 arg1Of EM-2,","
R2155 T2734 T2736 arg1Of ",",","
R2156 T2735 T2734 arg2Of LAMA-84,","
R2157 T2736 T2738 arg1Of ",",","
R2158 T2737 T2736 arg2Of CML-T1,","
R2159 T2738 T2740 arg1Of ",",","
R2160 T2739 T2738 arg2Of BV-173,","
R2161 T2740 T2732 arg2Of ",",and
R2162 T2741 T2740 arg2Of SD-1,","
R2163 T2743 T2744 arg1Of RPMI-8226,from
R2164 T2743 T2752 arg1Of RPMI-8226,und
R2165 T2751 T2744 arg2Of Mikroorganismen,from
R2166 T2751 T2745 arg1Of Mikroorganismen,the
R2167 T2751 T2746 arg1Of Mikroorganismen,DSMZ
R2168 T2751 T2747 arg1Of Mikroorganismen,(
R2169 T2751 T2748 arg1Of Mikroorganismen,Deutsche
R2170 T2751 T2749 arg1Of Mikroorganismen,Sammlung
R2171 T2751 T2750 arg1Of Mikroorganismen,von
R2172 T2752 T2742 arg2Of und,and
R2173 T2754 T2753 arg1Of GmbH,Zellkulturen
R2174 T2754 T2755 arg1Of GmbH,","
R2175 T2755 T2752 arg2Of ",",und
R2176 T2755 T2757 arg1Of ",",","
R2177 T2756 T2755 arg2Of Braunschweig,","
R2178 T2758 T2757 arg2Of Germany,","
R2179 T2758 T2759 arg1Of Germany,)
R2180 T2762 T2760 arg1Of lines,All
R2181 T2762 T2761 arg1Of lines,cell
R2182 T2762 T2771 arg1Of lines,were
R2183 T2762 T2772 arg1Of lines,IRF-4-negative
R2184 T2765 T2766 arg1Of BV-173,","
R2185 T2766 T2768 arg1Of ",",and
R2186 T2767 T2766 arg2Of SD-1,","
R2187 T2768 T2764 arg2Of and,except
R2188 T2769 T2768 arg2Of RPMI-8226,and
R2189 T2771 T2763 arg1Of were,","
R2190 T2771 T2764 arg1Of were,except
R2191 T2771 T2770 arg1Of were,","
R2192 T2772 T2771 arg2Of IRF-4-negative,were
R2263 T2863 T2864 arg1Of culture,and
R2264 T2864 T2862 arg1Of and,Cell
R2265 T2865 T2864 arg2Of stimulation,and
R2266 T2868 T2866 arg1Of lines,All
R2267 T2868 T2867 arg1Of lines,cell
R2268 T2868 T2869 arg1Of lines,were
R2269 T2868 T2870 arg2Of lines,maintained
R2270 T2870 T2869 arg2Of maintained,were
R2271 T2870 T2871 arg1Of maintained,at
R2272 T2872 T2873 arg1Of 5,%
R2273 T2874 T2871 arg2Of CO2,at
R2274 T2874 T2872 arg1Of CO2,5
R2275 T2874 T2875 arg1Of CO2,in
R2276 T2874 T2879 arg1Of CO2,with
R2277 T2874 T2889 arg2Of CO2,supplemented
R2278 T2878 T2875 arg2Of medium,in
R2279 T2878 T2876 arg1Of medium,RPMI
R2280 T2878 T2877 arg1Of medium,1640
R2281 T2880 T2881 arg1Of 1,%
R2282 T2882 T2879 arg2Of glutamine,with
R2283 T2882 T2880 arg1Of glutamine,1
R2284 T2882 T2883 arg1Of glutamine,(
R2285 T2885 T2883 arg2Of Eggenstein,(
R2286 T2885 T2884 arg1Of Eggenstein,Gibco/BRL
R2287 T2885 T2886 arg1Of Eggenstein,","
R2288 T2887 T2886 arg2Of Germany,","
R2289 T2888 T2883 arg3Of ),(
R2290 T2889 T2890 arg1Of supplemented,with
R2291 T2889 T2903 arg1Of supplemented,(
R2292 T2891 T2892 arg1Of 10,%
R2293 T2895 T2891 arg1Of serum,10
R2294 T2895 T2893 arg1Of serum,fetal
R2295 T2895 T2894 arg1Of serum,calf
R2296 T2895 T2896 arg1Of serum,(
R2297 T2895 T2899 arg1Of serum,","
R2298 T2897 T2896 arg2Of Gibco/BRL,(
R2299 T2898 T2896 arg3Of ),(
R2300 T2899 T2890 arg2Of ",",with
R2301 T2900 T2901 arg1Of 1,%
R2302 T2902 T2899 arg2Of penicillin/streptomycin,","
R2303 T2902 T2900 arg1Of penicillin/streptomycin,1
R2304 T2904 T2905 arg1Of Biochrom,","
R2305 T2905 T2903 arg2Of ",",(
R2306 T2905 T2907 arg1Of ",",","
R2307 T2906 T2905 arg2Of Berlin,","
R2308 T2908 T2907 arg2Of Germany,","
R2309 T2909 T2903 arg3Of ),(
R2310 T2913 T2911 arg2Of cells,indicated
R2311 T2913 T2914 arg1Of cells,were
R2312 T2913 T2915 arg2Of cells,treated
R2313 T2915 T2910 arg1Of treated,When
R2314 T2915 T2911 modOf treated,indicated
R2315 T2915 T2912 arg1Of treated,","
R2316 T2915 T2914 arg2Of treated,were
R2317 T2915 T2916 arg1Of treated,with
R2318 T2915 T2926 arg1Of treated,(
R2319 T2915 T2933 arg1Of treated,for
R2320 T2917 T2918 arg1Of 5-aza-2-deoxycytidine,(
R2321 T2917 T2921 arg1Of 5-aza-2-deoxycytidine,or
R2322 T2919 T2918 arg2Of AzadC,(
R2323 T2920 T2918 arg3Of ),(
R2324 T2921 T2916 arg2Of or,with
R2325 T2922 T2921 arg2Of 5-azacytidine,or
R2326 T2922 T2923 arg1Of 5-azacytidine,(
R2327 T2924 T2923 arg2Of AzaC,(
R2328 T2925 T2923 arg3Of ),(
R2329 T2927 T2928 arg1Of Sigma,","
R2330 T2928 T2926 arg2Of ",",(
R2331 T2928 T2930 arg1Of ",",","
R2332 T2929 T2928 arg2Of Taufkirchen,","
R2333 T2931 T2930 arg2Of Germany,","
R2334 T2932 T2926 arg3Of ),(
R2335 T2936 T2933 arg2Of periods,for
R2336 T2936 T2934 arg1Of periods,different
R2337 T2936 T2935 arg1Of periods,time
R2338 T2937 T2938 arg1Of Owing,to
R2339 T2937 T2945 arg1Of Owing,re-added
R2340 T2940 T2938 arg2Of chemical,to
R2341 T2940 T2939 arg1Of chemical,their
R2342 T2941 T2937 arg2Of instability,Owing
R2343 T2941 T2944 arg2Of instability,were
R2344 T2943 T2942 arg1Of substances,fresh
R2345 T2943 T2944 arg1Of substances,were
R2346 T2948 T2945 arg2Of h,re-added
R2347 T2948 T2946 arg1Of h,every
R2348 T2948 T2947 arg1Of h,24
R2438 T3062 T3063 arg1Of Sequencing,of
R2439 T3066 T3063 arg2Of promoter,of
R2440 T3066 T3064 arg1Of promoter,the
R2441 T3066 T3065 arg1Of promoter,IRF-4
R2442 T3068 T3067 arg2Of analysis,For
R2443 T3068 T3069 arg1Of analysis,of
R2444 T3073 T3069 arg2Of region,of
R2445 T3073 T3070 arg1Of region,the
R2446 T3073 T3071 arg1Of region,IRF-4
R2447 T3073 T3072 arg1Of region,promoter
R2448 T3073 T3074 arg1Of region,for
R2449 T3076 T3074 arg2Of aberrations,for
R2450 T3076 T3075 arg1Of aberrations,permanent
R2451 T3076 T3078 arg1Of aberrations,as
R2452 T3078 T3077 arg1Of as,such
R2453 T3079 T3080 arg1Of insertions/deletions,or
R2454 T3080 T3078 arg2Of or,as
R2455 T3081 T3080 arg2Of mutation,or
R2456 T3083 T3084 arg1Of we,PCR-amplified
R2457 T3084 T3067 arg1Of PCR-amplified,For
R2458 T3084 T3082 arg1Of PCR-amplified,","
R2459 T3086 T3084 arg2Of fragments,PCR-amplified
R2460 T3086 T3085 arg1Of fragments,two
R2461 T3086 T3087 arg1Of fragments,from
R2462 T3089 T3087 arg2Of DNA,from
R2463 T3089 T3088 arg1Of DNA,genomic
R2464 T3089 T3090 arg1Of DNA,","
R2465 T3089 T3091 arg1Of DNA,which
R2466 T3089 T3092 arg1Of DNA,was
R2467 T3089 T3093 arg2Of DNA,extracted
R2468 T3093 T3092 arg2Of extracted,was
R2469 T3093 T3094 arg1Of extracted,from
R2470 T3093 T3109 arg1Of extracted,as
R2471 T3097 T3094 arg2Of lines,from
R2472 T3097 T3095 arg2Of lines,depicted
R2473 T3097 T3096 arg1Of lines,cell
R2474 T3097 T3098 arg1Of lines,with
R2475 T3097 T3102 arg1Of lines,(
R2476 T3101 T3098 arg2Of kit,with
R2477 T3101 T3099 arg1Of kit,a
R2478 T3101 T3100 arg1Of kit,commercial
R2479 T3103 T3102 arg2Of Qiagen,(
R2480 T3103 T3104 arg1Of Qiagen,","
R2481 T3103 T3106 arg1Of Qiagen,","
R2482 T3105 T3104 arg2Of Hilde,","
R2483 T3107 T3106 arg2Of Germany,","
R2484 T3108 T3102 arg3Of ),(
R2485 T3110 T3109 arg2Of recommended,as
R2486 T3112 T3111 arg1Of primers,The
R2487 T3112 T3113 arg1Of primers,were
R2488 T3112 T3114 arg1Of primers,1-forward
R2489 T3113 T3115 arg1Of were,:
R2490 T3114 T3113 arg2Of 1-forward,were
R2491 T3116 T3117 arg1Of 5′-TTGAGATGGAGTCTTGCTCTGT-3′,","
R2492 T3117 T3119 arg1Of ",",:
R2493 T3118 T3117 arg2Of 1-reverse,","
R2494 T3120 T3121 arg1Of 5′-CCAGGACCTCAGGAGGCCAGTCA-3′,;
R2495 T3121 T3123 arg1Of ;,:
R2496 T3122 T3121 arg2Of 2-forward,;
R2497 T3124 T3125 arg1Of 5′-AGCGGTGAAACTGAGAGTGCGAGGT-3′,","
R2498 T3125 T3127 arg1Of ",",:
R2499 T3126 T3125 arg2Of 2-reverse,","
R2500 T3130 T3129 arg1Of products,The
R2501 T3130 T3131 arg1Of products,were
R2502 T3130 T3132 arg2Of products,cloned
R2503 T3132 T3131 arg2Of cloned,were
R2504 T3132 T3133 arg1Of cloned,with
R2505 T3138 T3133 arg2Of kit’,with
R2506 T3138 T3134 arg1Of kit’,the
R2507 T3138 T3135 arg1Of kit’,‘TOPO
R2508 T3138 T3136 arg1Of kit’,TA
R2509 T3138 T3137 arg1Of kit’,cloning
R2510 T3138 T3139 arg1Of kit’,(
R2511 T3140 T3139 arg2Of Invitrogen,(
R2512 T3140 T3141 arg1Of Invitrogen,","
R2513 T3140 T3143 arg1Of Invitrogen,","
R2514 T3142 T3141 arg2Of Groningen,","
R2515 T3145 T3143 arg2Of Netherlands,","
R2516 T3145 T3144 arg1Of Netherlands,The
R2517 T3146 T3139 arg3Of ),(
R2518 T3149 T3147 arg2Of amplification,After
R2519 T3149 T3148 arg1Of amplification,bacterial
R2520 T3149 T3150 arg1Of amplification,of
R2521 T3149 T3155 arg1Of amplification,by
R2522 T3154 T3150 arg2Of fragments,of
R2523 T3154 T3151 arg1Of fragments,the
R2524 T3154 T3152 arg2Of fragments,cloned
R2525 T3154 T3153 arg1Of fragments,PCR
R2526 T3157 T3155 arg2Of procedures,by
R2527 T3157 T3156 arg1Of procedures,standard
R2528 T3161 T3159 arg1Of three,at
R2529 T3161 T3160 arg1Of three,least
R2530 T3162 T3161 arg1Of clones,three
R2531 T3162 T3163 arg1Of clones,from
R2532 T3162 T3166 arg1Of clones,were
R2533 T3162 T3167 arg2Of clones,sequenced
R2534 T3165 T3163 arg2Of sample,from
R2535 T3165 T3164 arg1Of sample,each
R2536 T3167 T3147 arg1Of sequenced,After
R2537 T3167 T3158 arg1Of sequenced,","
R2538 T3167 T3166 arg2Of sequenced,were
R2539 T3167 T3168 arg1Of sequenced,with
R2540 T3167 T3172 arg1Of sequenced,(
R2541 T3167 T3185 arg1Of sequenced,as
R2542 T3171 T3168 arg2Of sequencer,with
R2543 T3171 T3169 arg1Of sequencer,an
R2544 T3171 T3170 arg2Of sequencer,automated
R2545 T3174 T3173 arg1Of Prism,ABI
R2546 T3174 T3175 arg1Of Prism,377
R2547 T3174 T3176 arg1Of Prism,","
R2548 T3174 T3179 arg1Of Prism,","
R2549 T3178 T3176 arg2Of Bio-systems,","
R2550 T3178 T3177 arg1Of Bio-systems,Applied
R2551 T3179 T3172 arg2Of ",",(
R2552 T3179 T3182 arg1Of ",",","
R2553 T3179 T3183 arg1Of ",",USA
R2554 T3181 T3179 arg2Of City,","
R2555 T3181 T3180 arg1Of City,Foster
R2556 T3184 T3172 arg3Of ),(
R2557 T3186 T3185 arg2Of recommended,as
R2558 T3189 T3186 arg1Of manufacturer,recommended
R2559 T3189 T3187 arg2Of manufacturer,by
R2560 T3189 T3188 arg1Of manufacturer,the
R2749 T3451 T3450 arg1Of analysis,Expression
R2750 T3453 T3452 arg1Of analyze,To
R2751 T3457 T3453 arg2Of level,analyze
R2752 T3457 T3454 arg1Of level,the
R2753 T3457 T3455 arg1Of level,IRF-4
R2754 T3457 T3456 arg1Of level,transcriptional
R2755 T3459 T3453 arg1Of RNA,analyze
R2756 T3459 T3460 arg1Of RNA,was
R2757 T3459 T3461 arg2Of RNA,extracted
R2758 T3461 T3452 modOf extracted,To
R2759 T3461 T3458 arg1Of extracted,","
R2760 T3461 T3460 arg2Of extracted,was
R2761 T3461 T3462 arg1Of extracted,from
R2762 T3463 T3462 arg2Of cells,from
R2763 T3463 T3464 arg1Of cells,using
R2764 T3467 T3464 arg2Of RNAzol-kit,using
R2765 T3467 T3465 arg1Of RNAzol-kit,the
R2766 T3467 T3466 arg1Of RNAzol-kit,commercial
R2767 T3467 T3468 arg1Of RNAzol-kit,(
R2768 T3469 T3470 arg1Of Paesel,","
R2769 T3470 T3468 arg2Of ",",(
R2770 T3470 T3472 arg1Of ",",","
R2771 T3471 T3470 arg2Of Frankfurt,","
R2772 T3473 T3472 arg2Of Germany,","
R2773 T3474 T3468 arg3Of ),(
R2774 T3476 T3475 arg1Of aliquot,An
R2775 T3476 T3477 arg1Of aliquot,of
R2776 T3476 T3482 arg1Of aliquot,was
R2777 T3476 T3483 arg2Of aliquot,used
R2778 T3481 T3477 arg2Of RNA,of
R2779 T3481 T3478 arg1Of RNA,1
R2780 T3481 T3479 arg1Of RNA,μg
R2781 T3481 T3480 arg1Of RNA,total
R2782 T3483 T3482 arg2Of used,was
R2783 T3483 T3484 arg1Of used,for
R2784 T3486 T3484 arg2Of synthesis,for
R2785 T3486 T3485 arg1Of synthesis,cDNA
R2786 T3487 T3483 arg3Of as,used
R2787 T3488 T3487 arg2Of described,as
R2788 T3488 T3489 arg1Of described,previously
R2789 T3489 T3490 arg1Of previously,(
R2790 T3491 T3490 arg2Of 27,(
R2791 T3492 T3490 arg3Of ),(
R2792 T3495 T3493 arg1Of analysis,RNA
R2793 T3495 T3494 arg1Of analysis,expression
R2794 T3495 T3496 arg1Of analysis,for
R2795 T3495 T3498 arg1Of analysis,and
R2796 T3497 T3496 arg2Of IRF-4,for
R2797 T3498 T3503 arg1Of and,was
R2798 T3498 T3504 arg2Of and,carried
R2799 T3502 T3498 arg2Of β-actin,and
R2800 T3502 T3499 arg1Of β-actin,the
R2801 T3502 T3500 arg1Of β-actin,reference
R2802 T3502 T3501 arg1Of β-actin,gene
R2803 T3504 T3503 arg2Of carried,was
R2804 T3504 T3505 arg1Of carried,out
R2805 T3504 T3509 arg1Of carried,as
R2806 T3508 T3504 arg1Of PCR,carried
R2807 T3508 T3506 arg2Of PCR,by
R2808 T3508 T3507 arg1Of PCR,semi-quantitative
R2809 T3510 T3509 arg2Of described,as
R2810 T3510 T3511 arg1Of described,previously
R2811 T3511 T3512 arg1Of previously,(
R2812 T3513 T3512 arg2Of "3,27",(
R2813 T3514 T3512 arg3Of ),(
R2814 T3516 T3515 arg1Of products,PCR
R2815 T3516 T3517 arg1Of products,were
R2816 T3516 T3518 arg2Of products,verified
R2817 T3518 T3517 arg2Of verified,were
R2818 T3521 T3518 arg1Of sequencing,verified
R2819 T3521 T3519 arg2Of sequencing,by
R2820 T3521 T3520 arg2Of sequencing,automated
R2821 T3523 T3522 arg1Of primers,PCR
R2822 T3523 T3524 arg1Of primers,and
R2823 T3524 T3526 arg1Of and,for
R2824 T3524 T3547 arg1Of and,were
R2825 T3524 T3548 arg2Of and,published
R2826 T3525 T3524 arg2Of conditions,and
R2827 T3528 T3526 arg2Of analysis,for
R2828 T3528 T3527 arg1Of analysis,expression
R2829 T3528 T3529 arg1Of analysis,of
R2830 T3530 T3531 arg1Of DNMT,or
R2831 T3531 T3529 arg2Of or,of
R2832 T3531 T3533 arg1Of or,(
R2833 T3532 T3531 arg2Of MBP,or
R2834 T3535 T3534 arg1Of DNMT3A,DNMT1
R2835 T3535 T3536 arg1Of DNMT3A,","
R2836 T3536 T3538 arg1Of ",",","
R2837 T3537 T3536 arg2Of DNMT3B,","
R2838 T3538 T3540 arg1Of ",",","
R2839 T3539 T3538 arg2Of MeCP,","
R2840 T3540 T3542 arg1Of ",",","
R2841 T3541 T3540 arg2Of MBD1,","
R2842 T3542 T3544 arg1Of ",",and
R2843 T3543 T3542 arg2Of MBD2,","
R2844 T3544 T3533 arg2Of and,(
R2845 T3545 T3544 arg2Of MBD4,and
R2846 T3546 T3533 arg3Of ),(
R2847 T3548 T3547 arg2Of published,were
R2848 T3548 T3549 arg1Of published,elsewhere
R2849 T3549 T3550 arg1Of elsewhere,(
R2850 T3551 T3550 arg2Of 28,(
R2851 T3552 T3550 arg3Of ),(
R2852 T3554 T3553 arg2Of analysis,For
R2853 T3554 T3555 arg1Of analysis,of
R2854 T3558 T3555 arg2Of expression,of
R2855 T3558 T3556 arg1Of expression,IRF-4
R2856 T3558 T3557 arg1Of expression,protein
R2857 T3563 T3560 arg1Of assay,a
R2858 T3563 T3561 arg1Of assay,standard
R2859 T3563 T3562 arg1Of assay,immunoblotting
R2860 T3563 T3564 arg1Of assay,was
R2861 T3563 T3565 arg2Of assay,performed
R2862 T3565 T3553 arg1Of performed,For
R2863 T3565 T3559 arg1Of performed,","
R2864 T3565 T3564 arg2Of performed,was
R2865 T3565 T3566 arg1Of performed,as
R2866 T3567 T3566 arg2Of described,as
R2867 T3567 T3568 arg1Of described,previously
R2868 T3568 T3569 arg1Of previously,(
R2869 T3570 T3569 arg2Of 29,(
R2870 T3571 T3569 arg3Of ),(
R2871 T3575 T3574 arg1Of lysates,protein
R2872 T3575 T3576 arg1Of lysates,were
R2873 T3575 T3577 arg2Of lysates,generated
R2874 T3577 T3572 arg1Of generated,Briefly
R2875 T3577 T3573 arg1Of generated,","
R2876 T3577 T3576 arg2Of generated,were
R2877 T3577 T3578 arg1Of generated,by
R2878 T3579 T3578 arg2Of incubating,by
R2879 T3579 T3618 arg1Of incubating,for
R2880 T3583 T3579 arg2Of cells,incubating
R2881 T3583 T3580 arg1Of cells,1
R2882 T3583 T3581 arg1Of cells,×
R2883 T3583 T3582 arg1Of cells,106
R2884 T3583 T3584 arg1Of cells,in
R2885 T3583 T3589 arg1Of cells,(
R2886 T3588 T3584 arg2Of buffer,in
R2887 T3588 T3585 arg1Of buffer,100
R2888 T3588 T3586 arg1Of buffer,µl
R2889 T3588 T3587 arg1Of buffer,RIPA
R2890 T3590 T3591 arg1Of 1,%
R2891 T3592 T3590 arg1Of NP-40,1
R2892 T3592 T3593 arg1Of NP-40,","
R2893 T3593 T3597 arg1Of ",",","
R2894 T3594 T3595 arg1Of 0.5,%
R2895 T3596 T3593 arg2Of sodiumdesoxycholate,","
R2896 T3596 T3594 arg1Of sodiumdesoxycholate,0.5
R2897 T3597 T3601 arg1Of ",",","
R2898 T3598 T3599 arg1Of 0.1,%
R2899 T3600 T3597 arg2Of SDS,","
R2900 T3600 T3598 arg1Of SDS,0.1
R2901 T3601 T3606 arg1Of ",",","
R2902 T3605 T3601 arg2Of fluoride,","
R2903 T3605 T3602 arg1Of fluoride,100
R2904 T3605 T3603 arg1Of fluoride,µg/ml
R2905 T3605 T3604 arg1Of fluoride,phenylmethylsulfonyl
R2906 T3606 T3610 arg1Of ",",","
R2907 T3609 T3606 arg2Of protease-inhibitory-mix,","
R2908 T3609 T3607 arg1Of protease-inhibitory-mix,10
R2909 T3609 T3608 arg1Of protease-inhibitory-mix,µl/ml
R2910 T3610 T3589 arg2Of ",",(
R2911 T3613 T3610 arg2Of sodiumorthovanadate,","
R2912 T3613 T3611 arg1Of sodiumorthovanadate,1
R2913 T3613 T3612 arg1Of sodiumorthovanadate,µmol/ml
R2914 T3613 T3614 arg1Of sodiumorthovanadate,in
R2915 T3616 T3614 arg2Of saline,in
R2916 T3616 T3615 arg1Of saline,phosphate-buffered
R2917 T3617 T3589 arg3Of ),(
R2918 T3620 T3618 arg2Of min,for
R2919 T3620 T3619 arg1Of min,30
R2920 T3620 T3621 arg1Of min,on
R2921 T3622 T3621 arg2Of ice,on
R2922 T3624 T3623 arg2Of centrifugation,After
R2923 T3627 T3626 arg1Of concentration,protein
R2924 T3627 T3628 arg1Of concentration,of
R2925 T3627 T3631 arg1Of concentration,was
R2926 T3627 T3632 arg2Of concentration,determined
R2927 T3630 T3628 arg2Of supernatant,of
R2928 T3630 T3629 arg1Of supernatant,the
R2929 T3632 T3623 arg1Of determined,After
R2930 T3632 T3625 arg1Of determined,","
R2931 T3632 T3631 arg2Of determined,was
R2932 T3632 T3635 arg1Of determined,(
R2933 T3632 T3642 arg1Of determined,as
R2934 T3634 T3632 arg1Of BCA-method,determined
R2935 T3634 T3633 arg2Of BCA-method,by
R2936 T3636 T3637 arg1Of Pierce,","
R2937 T3637 T3635 arg2Of ",",(
R2938 T3637 T3639 arg1Of ",",","
R2939 T3638 T3637 arg2Of Rockford,","
R2940 T3640 T3639 arg2Of IL,","
R2941 T3641 T3635 arg3Of ),(
R2942 T3643 T3642 arg2Of recommended,as
R2943 T3645 T3644 arg1Of lysates,Protein
R2944 T3645 T3646 arg1Of lysates,(
R2945 T3645 T3650 arg1Of lysates,were
R2946 T3645 T3651 arg2Of lysates,electrophoresed
R2947 T3645 T3656 arg2Of lysates,transferred
R2948 T3648 T3646 arg2Of µg,(
R2949 T3648 T3647 arg1Of µg,70–100
R2950 T3649 T3646 arg3Of ),(
R2951 T3651 T3652 arg1Of electrophoresed,on
R2952 T3651 T3655 arg1Of electrophoresed,and
R2953 T3654 T3652 arg2Of gels,on
R2954 T3654 T3653 arg1Of gels,polyacrylamide
R2955 T3655 T3650 arg2Of and,were
R2956 T3656 T3655 arg2Of transferred,and
R2957 T3656 T3657 arg1Of transferred,to
R2958 T3659 T3657 arg2Of PVDF-membrane,to
R2959 T3659 T3658 arg1Of PVDF-membrane,a
R2960 T3659 T3660 arg1Of PVDF-membrane,(
R2961 T3662 T3660 arg2Of P,(
R2962 T3662 T3661 arg1Of P,Immobilon
R2963 T3662 T3663 arg1Of P,","
R2964 T3662 T3666 arg1Of P,;
R2965 T3665 T3663 arg2Of µm,","
R2966 T3665 T3664 arg1Of µm,0.45
R2967 T3667 T3666 arg2Of Millipore,;
R2968 T3667 T3668 arg1Of Millipore,","
R2969 T3669 T3668 arg2Of Eschborn,","
R2970 T3669 T3670 arg1Of Eschborn,","
R2971 T3671 T3670 arg2Of Germany,","
R2972 T3672 T3660 arg3Of ),(
R2973 T3673 T3674 arg1Of Membranes,were
R2974 T3673 T3675 arg2Of Membranes,blocked
R2975 T3673 T3715 arg2Of Membranes,incubated
R2976 T3675 T3676 arg1Of blocked,with
R2977 T3675 T3713 arg1Of blocked,and
R2978 T3678 T3676 arg2Of %,with
R2979 T3678 T3677 arg1Of %,2.5
R2980 T3678 T3679 arg1Of %,blocking
R2981 T3678 T3690 arg1Of %,(
R2982 T3680 T3679 arg2Of reagent,blocking
R2983 T3680 T3681 arg1Of reagent,(
R2984 T3680 T3687 arg1Of reagent,in
R2985 T3683 T3681 arg2Of Mannheim,(
R2986 T3683 T3682 arg1Of Mannheim,Boehringer
R2987 T3683 T3684 arg1Of Mannheim,","
R2988 T3685 T3684 arg2Of Germany,","
R2989 T3686 T3681 arg3Of ),(
R2990 T3689 T3687 arg2Of buffer,in
R2991 T3689 T3688 arg1Of buffer,TBST
R2992 T3693 T3691 arg1Of Tris–HCL,4.44
R2993 T3693 T3692 arg1Of Tris–HCL,g/l
R2994 T3693 T3694 arg1Of Tris–HCL,","
R2995 T3694 T3698 arg1Of ",",","
R2996 T3697 T3694 arg2Of TrisOH,","
R2997 T3697 T3695 arg1Of TrisOH,2.65
R2998 T3697 T3696 arg1Of TrisOH,g/l
R2999 T3698 T3702 arg1Of ",",","
R3000 T3701 T3698 arg2Of NaCl,","
R3001 T3701 T3699 arg1Of NaCl,8.07
R3002 T3701 T3700 arg1Of NaCl,g/l
R3003 T3702 T3706 arg1Of ",",and
R3004 T3703 T3704 arg1Of 0.2,g/l
R3005 T3705 T3702 arg2Of KCl,","
R3006 T3705 T3703 arg1Of KCl,0.2
R3007 T3706 T3708 arg1Of and,µl/l
R3008 T3707 T3706 arg2Of 500,and
R3009 T3708 T3690 arg2Of µl/l,(
R3010 T3708 T3710 arg1Of µl/l,in
R3011 T3709 T3708 arg2Of Tween-20,µl/l
R3012 T3711 T3710 arg2Of H2O,in
R3013 T3712 T3690 arg3Of ),(
R3014 T3713 T3674 arg2Of and,were
R3015 T3713 T3739 arg1Of and,respectively
R3016 T3715 T3713 arg2Of incubated,and
R3017 T3715 T3714 arg1Of incubated,subsequently
R3018 T3715 T3716 arg1Of incubated,with
R3019 T3715 T3738 arg1Of incubated,","
R3020 T3718 T3716 arg2Of antibody,with
R3021 T3718 T3717 arg1Of antibody,primary
R3022 T3718 T3719 arg1Of antibody,as
R3023 T3723 T3721 arg1Of peroxidase-conjugated,and
R3024 T3723 T3722 arg1Of peroxidase-conjugated,horseradish
R3025 T3725 T3720 arg2Of antibody,indicated
R3026 T3725 T3723 arg1Of antibody,peroxidase-conjugated
R3027 T3725 T3724 arg1Of antibody,secondary
R3028 T3725 T3726 arg1Of antibody,","
R3029 T3726 T3719 arg2Of ",",as
R3030 T3726 T3731 arg1Of ",",(
R3031 T3727 T3728 arg1Of anti-mouse,or
R3032 T3729 T3728 arg2Of anti-goat,or
R3033 T3730 T3726 arg2Of IgG,","
R3034 T3730 T3727 arg1Of IgG,anti-mouse
R3035 T3730 T3729 arg1Of IgG,anti-goat
R3036 T3732 T3733 arg1Of DAKO,","
R3037 T3733 T3735 arg1Of ",",","
R3038 T3734 T3733 arg2Of Hamburg,","
R3039 T3735 T3731 arg2Of ",",(
R3040 T3736 T3735 arg2Of Germany,","
R3041 T3737 T3731 arg3Of ),(
R3042 T3741 T3740 arg1Of membranes,The
R3043 T3741 T3742 arg1Of membranes,were
R3044 T3741 T3744 arg2Of membranes,developed
R3045 T3744 T3742 arg2Of developed,were
R3046 T3744 T3743 arg1Of developed,then
R3047 T3744 T3745 arg1Of developed,with
R3048 T3749 T3745 arg2Of kit,with
R3049 T3749 T3746 arg1Of kit,an
R3050 T3749 T3747 arg1Of kit,ECL
R3051 T3749 T3748 arg1Of kit,detection
R3052 T3749 T3750 arg1Of kit,(
R3053 T3753 T3750 arg2Of Biotech,(
R3054 T3753 T3751 arg1Of Biotech,Amersham
R3055 T3753 T3752 arg1Of Biotech,Pharmacia
R3056 T3753 T3754 arg1Of Biotech,","
R3057 T3755 T3754 arg2Of Freiburg,","
R3058 T3755 T3756 arg1Of Freiburg,","
R3059 T3757 T3756 arg2Of Germany,","
R3060 T3758 T3750 arg3Of ),(
R3061 T3761 T3759 arg1Of antibodies,The
R3062 T3761 T3760 arg1Of antibodies,primary
R3063 T3761 T3762 arg1Of antibodies,were
R3064 T3764 T3763 arg1Of anti-IRF-4/ICSAT,goat
R3065 T3764 T3765 arg1Of anti-IRF-4/ICSAT,(
R3066 T3764 T3768 arg1Of anti-IRF-4/ICSAT,(
R3067 T3764 T3778 arg1Of anti-IRF-4/ICSAT,and
R3068 T3766 T3765 arg2Of M-17,(
R3069 T3767 T3765 arg3Of ),(
R3070 T3771 T3768 arg2Of Biotechnology,(
R3071 T3771 T3769 arg1Of Biotechnology,Santa
R3072 T3771 T3770 arg1Of Biotechnology,Cruz
R3073 T3771 T3772 arg1Of Biotechnology,","
R3074 T3774 T3772 arg2Of Cruz,","
R3075 T3774 T3773 arg1Of Cruz,Santa
R3076 T3774 T3775 arg1Of Cruz,","
R3077 T3776 T3775 arg2Of CA,","
R3078 T3777 T3768 arg3Of ),(
R3079 T3778 T3762 arg2Of and,were
R3080 T3778 T3784 arg1Of and,(
R3081 T3782 T3778 arg2Of AC-74,and
R3082 T3782 T3779 arg1Of AC-74,mouse
R3083 T3782 T3780 arg1Of AC-74,anti-β-actin
R3084 T3782 T3781 arg2Of AC-74,(
R3085 T3783 T3781 arg3Of ),(
R3086 T3785 T3784 arg2Of Sigma,(
R3087 T3786 T3784 arg3Of ),(
R3523 T4372 T4371 arg1Of restriction-PCR-assay,Methylation-specific
R3524 T4373 T4374 arg1Of DNA,was
R3525 T4373 T4375 arg2Of DNA,extracted
R3526 T4375 T4374 arg2Of extracted,was
R3527 T4375 T4376 arg1Of extracted,with
R3528 T4375 T4383 arg1Of extracted,as
R3529 T4379 T4376 arg2Of kit,with
R3530 T4379 T4377 arg1Of kit,a
R3531 T4379 T4378 arg1Of kit,commercial
R3532 T4379 T4380 arg1Of kit,(
R3533 T4381 T4380 arg2Of Qiagen,(
R3534 T4382 T4380 arg3Of ),(
R3535 T4384 T4383 arg2Of recommended,as
R3536 T4388 T4386 arg1Of ability,the
R3537 T4388 T4387 arg1Of ability,restriction
R3538 T4388 T4389 arg1Of ability,of
R3539 T4388 T4392 arg1Of ability,is
R3540 T4388 T4393 arg2Of ability,inhibited
R3541 T4391 T4389 arg2Of endonucleases,of
R3542 T4391 T4390 arg1Of endonucleases,several
R3543 T4393 T4385 arg2Of inhibited,Since
R3544 T4393 T4392 arg2Of inhibited,is
R3545 T4395 T4393 arg1Of methylation,inhibited
R3546 T4395 T4394 arg2Of methylation,by
R3547 T4395 T4396 arg1Of methylation,of
R3548 T4399 T4396 arg2Of sequence,of
R3549 T4399 T4397 arg1Of sequence,their
R3550 T4399 T4398 arg1Of sequence,target
R3551 T4401 T4402 arg1Of we,used
R3552 T4402 T4385 arg1Of used,Since
R3553 T4402 T4400 arg1Of used,","
R3554 T4405 T4403 arg1Of HpaII,methylation-sensitive
R3555 T4405 T4404 arg1Of HpaII,enzymes
R3556 T4405 T4406 arg1Of HpaII,and
R3557 T4406 T4409 arg1Of and,and
R3558 T4408 T4406 arg2Of Bsp143II,and
R3559 T4408 T4407 arg1Of Bsp143II,HaeII-isochizomer
R3560 T4409 T4402 arg2Of and,used
R3561 T4409 T4420 arg1Of and,(
R3562 T4410 T4409 arg2Of Bsh1236I,and
R3563 T4410 T4411 arg1Of Bsh1236I,(
R3564 T4413 T4411 arg2Of Fermentas,(
R3565 T4413 T4412 arg1Of Fermentas,MBI
R3566 T4413 T4414 arg1Of Fermentas,","
R3567 T4416 T4414 arg2Of Leon-Rot,","
R3568 T4416 T4415 arg1Of Leon-Rot,St
R3569 T4416 T4417 arg1Of Leon-Rot,","
R3570 T4418 T4417 arg2Of Germany,","
R3571 T4419 T4411 arg3Of ),(
R3572 T4421 T4420 arg2Of "20,24",(
R3573 T4422 T4420 arg3Of ),(
R3574 T4424 T4423 arg2Of control,As
R3575 T4424 T4432 arg1Of control,with
R3576 T4428 T4425 arg1Of MspI,the
R3577 T4428 T4426 arg1Of MspI,methylation-resistant
R3578 T4428 T4427 arg1Of MspI,enzyme
R3579 T4428 T4429 arg1Of MspI,and
R3580 T4429 T4424 arg2Of and,control
R3581 T4431 T4429 arg2Of enzyme,and
R3582 T4431 T4430 arg1Of enzyme,an
R3583 T4435 T4432 arg2Of site,with
R3584 T4435 T4433 arg1Of site,no
R3585 T4435 T4434 arg1Of site,recognition
R3586 T4435 T4436 arg1Of site,in
R3587 T4439 T4436 arg2Of promoter,in
R3588 T4439 T4437 arg1Of promoter,the
R3589 T4439 T4438 arg1Of promoter,target
R3590 T4441 T4443 arg1Of EcoRI,were
R3591 T4441 T4444 arg2Of EcoRI,used
R3592 T4444 T4423 arg1Of used,As
R3593 T4444 T4440 arg1Of used,","
R3594 T4444 T4442 arg1Of used,","
R3595 T4444 T4443 arg2Of used,were
R3596 T4445 T4446 arg1Of DNA,(
R3597 T4445 T4450 arg1Of DNA,was
R3598 T4445 T4451 arg2Of DNA,digested
R3599 T4448 T4446 arg2Of µg,(
R3600 T4448 T4447 arg1Of µg,0.8
R3601 T4449 T4446 arg3Of ),(
R3602 T4451 T4450 arg2Of digested,was
R3603 T4451 T4462 arg1Of digested,","
R3604 T4451 T4463 modOf digested,to
R3605 T4451 T4467 arg1Of digested,","
R3606 T4451 T4471 arg1Of digested,for
R3607 T4454 T4453 arg1Of U,40
R3608 T4457 T4451 arg1Of enzyme,digested
R3609 T4457 T4452 arg2Of enzyme,by
R3610 T4457 T4454 arg1Of enzyme,U
R3611 T4457 T4455 arg1Of enzyme,the
R3612 T4457 T4456 arg1Of enzyme,respective
R3613 T4457 T4458 arg1Of enzyme,for
R3614 T4457 T4461 arg1Of enzyme,and
R3615 T4460 T4458 arg2Of h,for
R3616 T4460 T4459 arg1Of h,6
R3617 T4464 T4463 arg1Of ensure,to
R3618 T4466 T4464 arg2Of cleavage,ensure
R3619 T4466 T4465 arg1Of cleavage,complete
R3620 T4470 T4468 arg1Of U,additional
R3621 T4470 T4469 arg1Of U,20
R3622 T4471 T4470 arg1Of for,U
R3623 T4473 T4471 arg2Of h,for
R3624 T4473 T4472 arg1Of h,16
R3625 T4475 T4474 arg1Of 100,Thereafter
R3626 T4476 T4475 arg1Of ng,100
R3627 T4476 T4477 arg1Of ng,of
R3628 T4476 T4480 arg1Of ng,was
R3629 T4476 T4481 arg2Of ng,used
R3630 T4479 T4477 arg2Of DNA,of
R3631 T4479 T4478 arg1Of DNA,digested
R3632 T4481 T4480 arg2Of used,was
R3633 T4481 T4482 arg1Of used,to
R3634 T4481 T4510 arg1Of used,)
R3635 T4485 T4482 arg2Of amplification,to
R3636 T4485 T4483 arg1Of amplification,a
R3637 T4485 T4484 arg1Of amplification,PCR
R3638 T4485 T4486 arg1Of amplification,of
R3639 T4485 T4489 arg1Of amplification,(
R3640 T4485 T4494 arg1Of amplification,spanning
R3641 T4485 T4507 modOf amplification,see
R3642 T4488 T4486 arg2Of fragments,of
R3643 T4488 T4487 arg1Of fragments,two
R3644 T4490 T4491 arg1Of F1,and
R3645 T4491 T4489 arg2Of and,(
R3646 T4492 T4491 arg2Of F2,and
R3647 T4493 T4489 arg3Of ),(
R3648 T4494 T4506 arg1Of spanning,;
R3649 T4495 T4494 arg2Of part,spanning
R3650 T4495 T4496 arg1Of part,of
R3651 T4501 T4500 arg2Of 30,(
R3652 T4502 T4500 arg3Of ),(
R3653 T4505 T4496 arg2Of U52683,of
R3654 T4505 T4497 arg1Of U52683,the
R3655 T4505 T4498 arg1Of U52683,IRF-4
R3656 T4505 T4499 arg1Of U52683,promoter
R3657 T4505 T4500 arg1Of U52683,(
R3658 T4505 T4503 arg1Of U52683,(
R3659 T4505 T4504 arg1Of U52683,GenBank
R3660 T4509 T4507 arg2Of 3A,see
R3661 T4509 T4508 arg1Of 3A,Figure
R3662 T4512 T4511 arg1Of sequences,The
R3663 T4512 T4513 arg1Of sequences,of
R3664 T4512 T4516 arg1Of sequences,were
R3665 T4512 T4517 arg1Of sequences,F1-forward
R3666 T4515 T4513 arg2Of primers,of
R3667 T4515 T4514 arg1Of primers,the
R3668 T4516 T4518 arg1Of were,:
R3669 T4517 T4516 arg2Of F1-forward,were
R3670 T4519 T4520 arg1Of 5′-TTGAGATGGAGTCTTGCTCTGT-3′,","
R3671 T4520 T4522 arg1Of ",",:
R3672 T4521 T4520 arg2Of F1-reverse,","
R3673 T4523 T4519 arg1Of ATCACTTCCAGACTTCAGTTCACCT-3′,5′-TTGAGATGGAGTCTTGCTCTGT-3′
R3674 T4523 T4521 arg1Of ATCACTTCCAGACTTCAGTTCACCT-3′,F1-reverse
R3675 T4523 T4524 arg1Of ATCACTTCCAGACTTCAGTTCACCT-3′,(
R3676 T4523 T4528 arg1Of ATCACTTCCAGACTTCAGTTCACCT-3′,;
R3677 T4526 T4524 arg2Of bp,(
R3678 T4526 T4525 arg1Of bp,341
R3679 T4527 T4524 arg3Of ),(
R3680 T4529 T4528 arg2Of F2-forward,;
R3681 T4529 T4530 arg1Of F2-forward,:
R3682 T4531 T4532 arg1Of 5′-AAGGTGAACTGAAGTCTGGAAGTGA-3′,","
R3683 T4532 T4534 arg1Of ",",:
R3684 T4533 T4532 arg2Of F2-reverse,","
R3685 T4535 T4536 arg1Of 5′-CCAGGACCTCAGGAGGCCAGTCA-3′,(
R3686 T4538 T4536 arg2Of bp,(
R3687 T4538 T4537 arg1Of bp,474
R3688 T4539 T4536 arg3Of ),(
R3689 T4542 T4540 arg1Of conditions,The
R3690 T4542 T4541 arg1Of conditions,PCR
R3691 T4542 T4543 arg1Of conditions,were
R3692 T4542 T4544 arg2Of conditions,described
R3693 T4544 T4543 arg2Of described,were
R3694 T4544 T4545 arg1Of described,elsewhere
R3695 T4545 T4546 arg1Of elsewhere,(
R3696 T4547 T4546 arg2Of 3,(
R3697 T4548 T4546 arg3Of ),(
R3698 T4549 T4550 arg1Of PCR,was
R3699 T4549 T4551 arg2Of PCR,performed
R3700 T4551 T4550 arg2Of performed,was
R3701 T4551 T4552 arg1Of performed,with
R3702 T4555 T4552 arg2Of temperature,with
R3703 T4555 T4553 arg1Of temperature,an
R3704 T4555 T4554 arg1Of temperature,annealing
R3705 T4555 T4556 arg1Of temperature,of
R3706 T4557 T4558 arg1Of 62°C,and
R3707 T4558 T4556 arg2Of and,of
R3708 T4560 T4558 arg2Of cycles,and
R3709 T4560 T4559 arg1Of cycles,35
R3710 T4562 T4563 arg1Of DNA,was
R3711 T4562 T4564 arg2Of DNA,methylated
R3712 T4564 T4561 arg2Of methylated,When
R3713 T4564 T4563 arg2Of methylated,was
R3714 T4564 T4565 arg1Of methylated,at
R3715 T4567 T4565 arg2Of sites,at
R3716 T4567 T4566 arg1Of sites,specific
R3717 T4571 T4569 arg1Of enzymes,the
R3718 T4571 T4570 arg1Of enzymes,sensitive
R3719 T4571 T4572 arg1Of enzymes,were
R3720 T4571 T4574 arg1Of enzymes,able
R3721 T4571 T4576 arg1Of enzymes,digest
R3722 T4572 T4573 arg1Of were,not
R3723 T4572 T4579 arg1Of were,and
R3724 T4574 T4572 arg2Of able,were
R3725 T4576 T4574 arg2Of digest,able
R3726 T4576 T4575 arg1Of digest,to
R3727 T4578 T4576 arg2Of DNA,digest
R3728 T4578 T4577 arg1Of DNA,the
R3729 T4579 T4561 arg1Of and,When
R3730 T4579 T4568 arg1Of and,","
R3731 T4579 T4583 arg1Of and,;
R3732 T4580 T4581 arg1Of amplification,took
R3733 T4581 T4579 arg2Of took,and
R3734 T4582 T4581 arg2Of place,took
R3735 T4585 T4584 arg2Of case,in
R3736 T4585 T4586 arg1Of case,of
R3737 T4588 T4586 arg2Of methylation,of
R3738 T4588 T4587 arg1Of methylation,no
R3739 T4590 T4591 arg1Of DNA,was
R3740 T4590 T4592 arg2Of DNA,digested
R3741 T4592 T4591 arg2Of digested,was
R3742 T4592 T4593 arg1Of digested,and
R3743 T4593 T4583 arg2Of and,;
R3744 T4593 T4584 arg1Of and,in
R3745 T4593 T4589 arg1Of and,","
R3746 T4595 T4594 arg1Of product,no
R3747 T4595 T4596 arg1Of product,was
R3748 T4595 T4597 arg2Of product,generated
R3749 T4597 T4593 arg2Of generated,and
R3750 T4597 T4596 arg2Of generated,was
R3751 T4600 T4598 arg1Of products,The
R3752 T4600 T4599 arg1Of products,PCR
R3753 T4600 T4601 arg1Of products,were
R3754 T4600 T4602 arg2Of products,electrophoresed
R3755 T4600 T4610 arg1Of products,were
R3756 T4600 T4611 arg2Of products,stained
R3757 T4600 T4616 arg2Of products,photographed
R3758 T4602 T4601 arg2Of electrophoresed,were
R3759 T4602 T4603 arg1Of electrophoresed,on
R3760 T4602 T4609 arg1Of electrophoresed,","
R3761 T4605 T4606 arg1Of 3,%
R3762 T4608 T4603 arg2Of gel,on
R3763 T4608 T4604 arg1Of gel,a
R3764 T4608 T4605 arg1Of gel,3
R3765 T4608 T4607 arg1Of gel,agarose
R3766 T4611 T4612 arg1Of stained,with
R3767 T4611 T4615 arg1Of stained,and
R3768 T4614 T4612 arg2Of bromide,with
R3769 T4614 T4613 arg1Of bromide,ethidium
R3770 T4615 T4609 arg2Of and,","
R3771 T4615 T4610 arg2Of and,were
R3772 T4616 T4615 arg2Of photographed,and
R3773 T4618 T4617 arg1Of products,PCR
R3774 T4618 T4619 arg1Of products,were
R3775 T4618 T4620 arg2Of products,verified
R3776 T4620 T4619 arg2Of verified,were
R3777 T4623 T4620 arg1Of sequencing,verified
R3778 T4623 T4621 arg2Of sequencing,by
R3779 T4623 T4622 arg2Of sequencing,automated
R4058 T4944 T4943 arg1Of treatment,Bisulfite
R4059 T4945 T4946 arg1Of DNA,was
R4060 T4945 T4947 arg2Of DNA,extracted
R4061 T4947 T4946 arg2Of extracted,was
R4062 T4947 T4948 arg1Of extracted,as
R4063 T4949 T4948 arg2Of described,as
R4064 T4949 T4950 arg1Of described,above
R4065 T4952 T4951 arg1Of treatment,Bisulfite
R4066 T4952 T4953 arg1Of treatment,of
R4067 T4952 T4955 arg1Of treatment,","
R4068 T4952 T4956 arg1Of treatment,leading
R4069 T4952 T4962 modOf treatment,to
R4070 T4952 T4978 arg1Of treatment,follows
R4071 T4954 T4953 arg2Of DNA,of
R4072 T4956 T4957 arg1Of leading,to
R4073 T4958 T4957 arg2Of conversion,to
R4074 T4958 T4959 arg1Of conversion,of
R4075 T4961 T4959 arg2Of cytosine,of
R4076 T4961 T4960 arg1Of cytosine,unmethylated
R4077 T4963 T4972 arg1Of uracil,","
R4078 T4964 T4965 arg1Of residues,and
R4079 T4965 T4963 arg2Of and,uracil
R4080 T4967 T4965 arg2Of change,and
R4081 T4967 T4966 arg1Of change,no
R4082 T4967 T4968 arg1Of change,of
R4083 T4971 T4968 arg2Of residues,of
R4084 T4971 T4969 arg2Of residues,methylated
R4085 T4971 T4970 arg1Of residues,cytosine
R4086 T4972 T4962 arg1Of ",",to
R4087 T4974 T4972 arg2Of performed,","
R4088 T4974 T4973 arg2Of performed,was
R4089 T4974 T4975 arg1Of performed,as
R4090 T4976 T4975 arg2Of described,as
R4091 T4976 T4977 arg1Of described,as
R4092 T4982 T4981 arg1Of µg,1
R4093 T4982 T4983 arg1Of µg,of
R4094 T4982 T4988 arg1Of µg,of
R4095 T4982 T5004 arg1Of µg,were
R4096 T4982 T5005 arg2Of µg,denaturated
R4097 T4984 T4985 arg1Of DNA,and
R4098 T4985 T4983 arg2Of and,of
R4099 T4987 T4985 arg2Of µg,and
R4100 T4987 T4986 arg1Of µg,2
R4101 T4989 T4990 arg1Of poly,(
R4102 T4991 T4990 arg2Of dA–dT,(
R4103 T4992 T4990 arg3Of ),(
R4104 T4996 T4995 arg2Of dA–dT,(
R4105 T4997 T4995 arg3Of ),(
R4106 T4998 T4988 arg2Of copolymers,of
R4107 T4998 T4989 arg1Of copolymers,poly
R4108 T4998 T4993 arg1Of copolymers,(
R4109 T4998 T4994 arg1Of copolymers,poly
R4110 T4998 T4995 arg1Of copolymers,(
R4111 T4998 T4999 arg1Of copolymers,(
R4112 T5002 T4999 arg2Of Biotech,(
R4113 T5002 T5000 arg1Of Biotech,Amersham
R4114 T5002 T5001 arg1Of Biotech,Pharmacia
R4115 T5003 T4999 arg3Of ),(
R4116 T5005 T4979 arg1Of denaturated,Briefly
R4117 T5005 T4980 arg1Of denaturated,","
R4118 T5005 T5004 arg2Of denaturated,were
R4119 T5005 T5006 arg1Of denaturated,for
R4120 T5005 T5009 arg1Of denaturated,at
R4121 T5005 T5011 arg1Of denaturated,in
R4122 T5005 T5015 arg1Of denaturated,in
R4123 T5008 T5006 arg2Of min,for
R4124 T5008 T5007 arg1Of min,20
R4125 T5010 T5009 arg2Of 42°C,at
R4126 T5012 T5013 arg1Of 0.3,M
R4127 T5014 T5011 arg2Of NaOH,in
R4128 T5014 T5012 arg1Of NaOH,0.3
R4129 T5017 T5015 arg2Of volume,in
R4130 T5017 T5016 arg1Of volume,a
R4131 T5017 T5018 arg1Of volume,of
R4132 T5020 T5018 arg2Of µl,of
R4133 T5020 T5019 arg1Of µl,50
R4134 T5022 T5021 arg1Of solutions,Fresh
R4135 T5022 T5023 arg1Of solutions,of
R4136 T5022 T5047 arg1Of solutions,were
R4137 T5022 T5048 arg2Of solutions,added
R4138 T5025 T5024 arg1Of µl,30
R4139 T5025 T5026 arg1Of µl,of
R4140 T5025 T5033 arg1Of µl,and
R4141 T5027 T5028 arg1Of 10,mM
R4142 T5029 T5026 arg2Of hydrochinon,of
R4143 T5029 T5027 arg1Of hydrochinon,10
R4144 T5029 T5030 arg1Of hydrochinon,(
R4145 T5031 T5030 arg2Of Sigma,(
R4146 T5032 T5030 arg3Of ),(
R4147 T5033 T5023 arg2Of and,of
R4148 T5035 T5033 arg2Of µl,and
R4149 T5035 T5034 arg1Of µl,530
R4150 T5035 T5036 arg1Of µl,of
R4151 T5037 T5038 arg1Of 3,M
R4152 T5040 T5036 arg2Of bisulfite,of
R4153 T5040 T5037 arg1Of bisulfite,3
R4154 T5040 T5039 arg1Of bisulfite,sodium
R4155 T5040 T5041 arg1Of bisulfite,(
R4156 T5042 T5041 arg2Of pH,(
R4157 T5042 T5043 arg1Of pH,5.0
R4158 T5042 T5044 arg1Of pH,;
R4159 T5045 T5044 arg2Of Sigma,;
R4160 T5046 T5041 arg3Of ),(
R4161 T5048 T5047 arg2Of added,were
R4162 T5051 T5050 arg1Of solution,the
R4163 T5051 T5052 arg1Of solution,was
R4164 T5051 T5054 arg2Of solution,mixed
R4165 T5051 T5056 arg2Of solution,overlayed
R4166 T5051 T5061 arg2Of solution,incubated
R4167 T5054 T5055 arg1Of mixed,","
R4168 T5055 T5060 arg1Of ",",and
R4169 T5056 T5055 arg2Of overlayed,","
R4170 T5056 T5057 arg1Of overlayed,with
R4171 T5059 T5057 arg2Of oil,with
R4172 T5059 T5058 arg1Of oil,mineral
R4173 T5060 T5049 arg1Of and,","
R4174 T5060 T5052 arg2Of and,was
R4175 T5060 T5053 arg1Of and,gently
R4176 T5061 T5060 arg2Of incubated,and
R4177 T5061 T5062 arg1Of incubated,in
R4178 T5064 T5062 arg2Of dark,in
R4179 T5064 T5063 arg1Of dark,the
R4180 T5067 T5066 arg1Of h,12–13
R4181 T5067 T5068 arg1Of h,at
R4182 T5067 T5073 arg1Of h,was
R4183 T5067 T5074 arg2Of h,recovered
R4184 T5072 T5068 arg2Of phase,at
R4185 T5072 T5069 arg1Of phase,50°C.
R4186 T5072 T5070 arg1Of phase,The
R4187 T5072 T5071 arg1Of phase,aqueous
R4188 T5074 T5073 arg2Of recovered,was
R4189 T5074 T5075 modOf recovered,using
R4190 T5074 T5081 arg1Of recovered,(
R4191 T5080 T5075 arg2Of system’,using
R4192 T5080 T5076 arg1Of system’,the
R4193 T5080 T5077 arg1Of system’,‘Wizard
R4194 T5080 T5078 arg1Of system’,DNA
R4195 T5080 T5079 arg1Of system’,clean-up
R4196 T5082 T5083 arg1Of Promega,","
R4197 T5083 T5081 arg2Of ",",(
R4198 T5083 T5085 arg1Of ",",","
R4199 T5084 T5083 arg2Of Mannheim,","
R4200 T5086 T5085 arg2Of Germany,","
R4201 T5087 T5081 arg3Of ),(
R4202 T5090 T5088 arg1Of DNA,The
R4203 T5090 T5089 arg2Of DNA,purified
R4204 T5090 T5091 arg1Of DNA,was
R4205 T5090 T5093 arg2Of DNA,mixed
R4206 T5090 T5106 arg2Of DNA,incubated
R4207 T5093 T5094 arg1Of mixed,with
R4208 T5093 T5105 arg1Of mixed,and
R4209 T5095 T5096 arg1Of 1,M
R4210 T5097 T5094 arg2Of NaOH,with
R4211 T5097 T5095 arg1Of NaOH,1
R4212 T5097 T5098 arg1Of NaOH,to
R4213 T5101 T5098 arg2Of concentration,to
R4214 T5101 T5099 arg1Of concentration,a
R4215 T5101 T5100 arg1Of concentration,final
R4216 T5101 T5102 arg1Of concentration,of
R4217 T5104 T5102 arg2Of M,of
R4218 T5104 T5103 arg1Of M,0.3
R4219 T5105 T5091 arg2Of and,was
R4220 T5105 T5092 arg1Of and,subsequently
R4221 T5106 T5105 arg2Of incubated,and
R4222 T5106 T5107 arg1Of incubated,for
R4223 T5106 T5110 arg1Of incubated,at
R4224 T5106 T5112 modOf incubated,to
R4225 T5109 T5107 arg2Of min,for
R4226 T5109 T5108 arg1Of min,20
R4227 T5111 T5110 arg2Of 37°C,at
R4228 T5113 T5112 arg1Of ensure,to
R4229 T5115 T5113 arg2Of desulfonisation,ensure
R4230 T5115 T5114 arg1Of desulfonisation,complete
R4231 T5116 T5117 arg1Of DNA,was
R4232 T5116 T5138 arg1Of DNA,resuspended
R4233 T5117 T5137 arg1Of was,and
R4234 T5118 T5117 arg2Of ethanol,was
R4235 T5118 T5119 arg2Of ethanol,precipitated
R4236 T5119 T5120 arg1Of precipitated,in
R4237 T5122 T5120 arg2Of presence,in
R4238 T5122 T5121 arg1Of presence,the
R4239 T5122 T5123 arg1Of presence,of
R4240 T5122 T5131 arg1Of presence,","
R4241 T5122 T5132 arg2Of presence,washed
R4242 T5125 T5123 arg2Of vol,of
R4243 T5125 T5124 arg1Of vol,1/10
R4244 T5125 T5126 arg1Of vol,of
R4245 T5127 T5128 arg1Of 3,M
R4246 T5130 T5126 arg2Of acetate,of
R4247 T5130 T5127 arg1Of acetate,3
R4248 T5130 T5129 arg1Of acetate,sodium
R4249 T5132 T5133 arg1Of washed,with
R4250 T5134 T5135 arg1Of 70,%
R4251 T5136 T5133 arg2Of ethanol,with
R4252 T5136 T5134 arg1Of ethanol,70
R4253 T5138 T5137 arg2Of resuspended,and
R4254 T5138 T5139 arg1Of resuspended,in
R4255 T5142 T5139 arg2Of H2O,in
R4256 T5142 T5140 arg1Of H2O,50
R4257 T5142 T5141 arg1Of H2O,µl
R4258 T5145 T5143 arg1Of amplification,Subsequent
R4259 T5145 T5144 arg1Of amplification,PCR
R4260 T5145 T5146 arg1Of amplification,of
R4261 T5145 T5151 arg1Of amplification,was
R4262 T5145 T5152 arg2Of amplification,used
R4263 T5150 T5146 arg2Of DNA,of
R4264 T5150 T5147 arg1Of DNA,4
R4265 T5150 T5148 arg1Of DNA,µl
R4266 T5150 T5149 arg1Of DNA,bisulfite-treated
R4267 T5152 T5151 arg2Of used,was
R4268 T5152 T5153 arg1Of used,for
R4269 T5152 T5167 arg1Of used,into
R4270 T5152 T5179 arg1Of used,(
R4271 T5154 T5153 arg2Of cloning,for
R4272 T5154 T5155 arg1Of cloning,of
R4273 T5157 T5155 arg2Of fragments,of
R4274 T5157 T5156 arg1Of fragments,two
R4275 T5157 T5158 arg1Of fragments,of
R4276 T5157 T5162 arg1Of fragments,(
R4277 T5161 T5158 arg2Of promoter,of
R4278 T5161 T5159 arg1Of promoter,the
R4279 T5161 T5160 arg1Of promoter,IRF-4
R4280 T5163 T5164 arg1Of BS-I,and
R4281 T5164 T5162 arg2Of and,(
R4282 T5165 T5164 arg2Of BS-II,and
R4283 T5166 T5162 arg3Of ),(
R4284 T5169 T5167 arg2Of vector,into
R4285 T5169 T5168 arg1Of vector,pCR2.1
R4286 T5169 T5170 arg1Of vector,with
R4287 T5175 T5170 arg2Of kit’,with
R4288 T5175 T5171 arg1Of kit’,the
R4289 T5175 T5172 arg1Of kit’,‘TOPO
R4290 T5175 T5173 arg1Of kit’,TA
R4291 T5175 T5174 arg1Of kit’,cloning
R4292 T5175 T5176 arg1Of kit’,(
R4293 T5177 T5176 arg2Of Invitrogen,(
R4294 T5178 T5176 arg3Of ),(
R4295 T5180 T5179 arg2Of see,(
R4296 T5182 T5180 arg2Of 3A,see
R4297 T5182 T5181 arg1Of 3A,Figure
R4298 T5183 T5179 arg3Of ),(
R4299 T5185 T5184 arg1Of primers,The
R4300 T5185 T5186 arg2Of primers,used
R4301 T5185 T5196 arg1Of primers,contain
R4302 T5186 T5187 arg1Of used,for
R4303 T5189 T5187 arg2Of amplification,for
R4304 T5189 T5188 arg1Of amplification,PCR
R4305 T5189 T5190 arg1Of amplification,of
R4306 T5192 T5193 arg1Of BS-I,and
R4307 T5194 T5193 arg2Of BS-II,and
R4308 T5195 T5190 arg2Of fragments,of
R4309 T5195 T5191 arg1Of fragments,the
R4310 T5195 T5192 arg1Of fragments,BS-I
R4311 T5195 T5194 arg1Of fragments,BS-II
R4312 T5196 T5219 arg1Of contain,:
R4313 T5196 T5221 arg1Of contain,5′-TATTTGGATTTTTAGGGAGTTTTTTTT-3′
R4314 T5196 T5229 arg1Of contain,;
R4315 T5196 T5231 arg1Of contain,5′-AGTTTAATAGTTTAAGGGAGTTGGGT-3′
R4316 T5200 T5196 arg2Of sequence,contain
R4317 T5200 T5197 arg1Of sequence,the
R4318 T5200 T5198 arg1Of sequence,putative
R4319 T5200 T5199 arg1Of sequence,altered
R4320 T5200 T5201 arg1Of sequence,of
R4321 T5204 T5201 arg2Of strand,of
R4322 T5204 T5202 arg1Of strand,the
R4323 T5204 T5203 arg1Of strand,sense
R4324 T5204 T5205 arg1Of strand,due
R4325 T5207 T5205 arg2Of bisulfite,due
R4326 T5207 T5206 arg1Of bisulfite,to
R4327 T5208 T5207 arg2Of treatment,bisulfite
R4328 T5208 T5209 arg1Of treatment,(
R4329 T5212 T5210 arg2Of residues,converted
R4330 T5212 T5211 arg1Of residues,cytosine
R4331 T5212 T5213 arg1Of residues,are
R4332 T5212 T5214 arg2Of residues,written
R4333 T5214 T5209 arg2Of written,(
R4334 T5214 T5213 arg2Of written,are
R4335 T5214 T5215 arg1Of written,in
R4336 T5217 T5215 arg2Of letters,in
R4337 T5217 T5216 arg1Of letters,bold
R4338 T5218 T5209 arg3Of ),(
R4339 T5221 T5220 arg1Of 5′-TATTTGGATTTTTAGGGAGTTTTTTTT-3′,BS-I-forward
R4340 T5221 T5222 arg1Of 5′-TATTTGGATTTTTAGGGAGTTTTTTTT-3′,","
R4341 T5224 T5222 arg2Of 5′-ACCCAACTCCCTTAAACTATTAAACT-3′,","
R4342 T5224 T5223 arg1Of 5′-ACCCAACTCCCTTAAACTATTAAACT-3′,BS-I-reverse
R4343 T5224 T5225 arg1Of 5′-ACCCAACTCCCTTAAACTATTAAACT-3′,(
R4344 T5227 T5225 arg2Of bp,(
R4345 T5227 T5226 arg1Of bp,187
R4346 T5228 T5225 arg3Of ),(
R4347 T5231 T5230 arg1Of 5′-AGTTTAATAGTTTAAGGGAGTTGGGT-3′,BS-II-forward
R4348 T5231 T5232 arg1Of 5′-AGTTTAATAGTTTAAGGGAGTTGGGT-3′,","
R4349 T5234 T5232 arg2Of 5′-CTCACCCTAAACTCAAAACTAAAAAC-3′,","
R4350 T5234 T5233 arg1Of 5′-CTCACCCTAAACTCAAAACTAAAAAC-3′,BS-II-reverse
R4351 T5234 T5235 arg1Of 5′-CTCACCCTAAACTCAAAACTAAAAAC-3′,(
R4352 T5237 T5235 arg2Of bp,(
R4353 T5237 T5236 arg1Of bp,674
R4354 T5238 T5235 arg3Of ),(
R4355 T5241 T5239 arg2Of amplification,After
R4356 T5241 T5240 arg1Of amplification,bacterial
R4357 T5241 T5242 arg1Of amplification,of
R4358 T5241 T5247 arg1Of amplification,by
R4359 T5246 T5242 arg2Of fragments,of
R4360 T5246 T5243 arg1Of fragments,the
R4361 T5246 T5244 arg2Of fragments,cloned
R4362 T5246 T5245 arg1Of fragments,PCR
R4363 T5249 T5247 arg2Of procedures,by
R4364 T5249 T5248 arg1Of procedures,standard
R4365 T5252 T5251 arg1Of clones,eight
R4366 T5252 T5253 arg1Of clones,from
R4367 T5252 T5256 arg1Of clones,were
R4368 T5252 T5257 arg2Of clones,sequenced
R4369 T5255 T5253 arg2Of sample,from
R4370 T5255 T5254 arg1Of sample,each
R4371 T5257 T5239 arg1Of sequenced,After
R4372 T5257 T5250 arg1Of sequenced,","
R4373 T5257 T5256 arg2Of sequenced,were
R4374 T5257 T5258 arg1Of sequenced,with
R4375 T5257 T5262 arg1Of sequenced,(
R4376 T5261 T5258 arg2Of sequencer,with
R4377 T5261 T5259 arg1Of sequencer,an
R4378 T5261 T5260 arg2Of sequencer,automated
R4379 T5264 T5262 arg2Of Prism,(
R4380 T5264 T5263 arg1Of Prism,ABI
R4381 T5264 T5265 arg1Of Prism,377
R4382 T5264 T5266 arg1Of Prism,","
R4383 T5268 T5266 arg2Of Biosystems,","
R4384 T5268 T5267 arg1Of Biosystems,Applied
R4385 T5269 T5262 arg3Of ),(
R4762 T5702 T5701 arg1Of vitro,In
R4763 T5703 T5704 arg1Of methylation,and
R4764 T5705 T5704 arg2Of reporter,and
R4765 T5707 T5702 arg1Of assays,vitro
R4766 T5707 T5703 arg1Of assays,methylation
R4767 T5707 T5705 arg1Of assays,reporter
R4768 T5707 T5706 arg1Of assays,gene
R4769 T5712 T5708 arg1Of construct,The
R4770 T5712 T5709 arg1Of construct,IRF-4
R4771 T5712 T5710 arg1Of construct,promoter-reporter
R4772 T5712 T5711 arg1Of construct,gene
R4773 T5712 T5713 arg1Of construct,was
R4774 T5712 T5715 arg2Of construct,provided
R4775 T5715 T5713 arg2Of provided,was
R4776 T5715 T5714 arg1Of provided,generously
R4777 T5718 T5715 arg1Of Hiscott,provided
R4778 T5718 T5716 arg2Of Hiscott,by
R4779 T5718 T5717 arg1Of Hiscott,J.
R4780 T5718 T5719 arg1Of Hiscott,(
R4781 T5720 T5719 arg2Of 31,(
R4782 T5721 T5719 arg3Of ),(
R4783 T5722 T5723 arg1Of Constructs,were
R4784 T5722 T5724 arg2Of Constructs,methylated
R4785 T5724 T5723 arg2Of methylated,were
R4786 T5724 T5726 arg1Of methylated,vitro
R4787 T5724 T5727 arg1Of methylated,with
R4788 T5724 T5734 arg1Of methylated,as
R4789 T5724 T5743 arg1Of methylated,and
R4790 T5726 T5725 arg1Of vitro,in
R4791 T5729 T5727 arg2Of Methylase,with
R4792 T5729 T5728 arg1Of Methylase,CpG
R4793 T5729 T5730 arg1Of Methylase,(
R4794 T5731 T5730 arg2Of M.Sss,(
R4795 T5731 T5732 arg1Of M.Sss,I
R4796 T5733 T5730 arg3Of ),(
R4797 T5735 T5734 arg2Of recommended,as
R4798 T5738 T5735 arg1Of manufacturer,recommended
R4799 T5738 T5736 arg2Of manufacturer,by
R4800 T5738 T5737 arg1Of manufacturer,the
R4801 T5738 T5739 arg1Of manufacturer,(
R4802 T5741 T5739 arg2Of Biolabs,(
R4803 T5741 T5740 arg1Of Biolabs,NE
R4804 T5742 T5739 arg3Of ),(
R4805 T5745 T5744 arg1Of methylation,complete
R4806 T5745 T5746 arg1Of methylation,was
R4807 T5745 T5747 arg2Of methylation,checked
R4808 T5747 T5743 arg2Of checked,and
R4809 T5747 T5746 arg2Of checked,was
R4810 T5747 T5748 arg1Of checked,via
R4811 T5750 T5748 arg2Of analysis,via
R4812 T5750 T5749 arg1Of analysis,restriction
R4813 T5750 T5751 arg1Of analysis,(
R4814 T5753 T5751 arg2Of 5A,(
R4815 T5753 T5752 arg1Of 5A,Figure
R4816 T5754 T5751 arg3Of ),(
R4817 T5756 T5755 arg1Of gene,Reporter
R4818 T5756 T5766 modOf gene,were
R4819 T5756 T5768 arg1Of gene,similar
R4820 T5757 T5758 arg1Of assays,using
R4821 T5757 T5766 arg1Of assays,were
R4822 T5757 T5767 arg2Of assays,performed
R4823 T5762 T5758 arg2Of assay,using
R4824 T5762 T5759 arg1Of assay,the
R4825 T5762 T5760 arg1Of assay,dual
R4826 T5762 T5761 arg1Of assay,luciferase
R4827 T5762 T5763 arg1Of assay,(
R4828 T5764 T5763 arg2Of Promega,(
R4829 T5765 T5763 arg3Of ),(
R4830 T5767 T5766 arg2Of performed,were
R4831 T5768 T5769 arg1Of similar,to
R4832 T5771 T5756 arg1Of reports,gene
R4833 T5771 T5770 arg1Of reports,previous
R4834 T5771 T5772 arg1Of reports,(
R4835 T5773 T5772 arg2Of 29,(
R4836 T5774 T5772 arg3Of ),(
R4837 T5778 T5777 arg1Of nM,5
R4838 T5778 T5779 arg1Of nM,of
R4839 T5778 T5783 arg1Of nM,and
R4840 T5782 T5779 arg2Of construct,of
R4841 T5782 T5780 arg1Of construct,the
R4842 T5782 T5781 arg1Of construct,reporter
R4843 T5783 T5793 arg1Of and,were
R4844 T5783 T5794 arg2Of and,transientlyco-expressed
R4845 T5787 T5783 arg2Of construct,and
R4846 T5787 T5784 arg1Of construct,the
R4847 T5787 T5785 arg1Of construct,transfection
R4848 T5787 T5786 arg1Of construct,control
R4849 T5787 T5788 arg1Of construct,expressing
R4850 T5792 T5788 arg2Of gene,expressing
R4851 T5792 T5789 arg1Of gene,the
R4852 T5792 T5790 arg1Of gene,renilla
R4853 T5792 T5791 arg1Of gene,luciferase
R4854 T5794 T5775 arg1Of transientlyco-expressed,Briefly
R4855 T5794 T5776 arg1Of transientlyco-expressed,","
R4856 T5794 T5793 arg2Of transientlyco-expressed,were
R4857 T5794 T5795 arg1Of transientlyco-expressed,via
R4858 T5796 T5795 arg2Of electroporation,via
R4859 T5799 T5797 arg1Of construct,The
R4860 T5799 T5798 arg1Of construct,control
R4861 T5799 T5800 arg1Of construct,served
R4862 T5800 T5801 arg1Of served,as
R4863 T5804 T5801 arg2Of reference,as
R4864 T5804 T5802 arg1Of reference,an
R4865 T5804 T5803 arg1Of reference,internal
R4866 T5804 T5805 arg1Of reference,for
R4867 T5807 T5805 arg2Of efficiency,for
R4868 T5807 T5806 arg1Of efficiency,transfection
R4869 T5809 T5808 arg1Of hours,Forty-eight
R4870 T5810 T5809 arg1Of after,hours
R4871 T5811 T5810 arg2Of transfection,after
R4872 T5814 T5813 arg1Of activity,luciferase
R4873 T5814 T5815 arg1Of activity,was
R4874 T5814 T5816 arg2Of activity,measured
R4875 T5816 T5810 arg1Of measured,after
R4876 T5816 T5812 arg1Of measured,","
R4877 T5816 T5815 arg2Of measured,was
R4878 T5816 T5817 arg1Of measured,with
R4879 T5816 T5823 arg1Of measured,(
R4880 T5822 T5817 arg2Of microlumat,with
R4881 T5822 T5818 arg1Of microlumat,a
R4882 T5822 T5819 arg1Of microlumat,LB
R4883 T5822 T5820 arg1Of microlumat,96
R4884 T5822 T5821 arg1Of microlumat,P
R4885 T5827 T5823 arg2Of Berthold,(
R4886 T5827 T5824 arg1Of Berthold,EG
R4887 T5827 T5825 arg1Of Berthold,&
R4888 T5827 T5826 arg1Of Berthold,G
R4889 T5827 T5828 arg1Of Berthold,","
R4890 T5830 T5828 arg2Of Wildbad,","
R4891 T5830 T5829 arg1Of Wildbad,Bad
R4892 T5830 T5831 arg1Of Wildbad,","
R4893 T5832 T5831 arg2Of Germany,","
R4894 T5833 T5823 arg3Of ),(
R4895 T5836 T5834 arg1Of activation,IRF-4
R4896 T5836 T5835 arg1Of activation,promoter
R4897 T5836 T5837 arg1Of activation,was
R4898 T5836 T5838 arg2Of activation,quantified
R4899 T5838 T5837 arg2Of quantified,was
R4900 T5838 T5839 arg1Of quantified,as
R4901 T5841 T5839 arg2Of ratio,as
R4902 T5841 T5840 arg1Of ratio,a
R4903 T5841 T5842 arg1Of ratio,of
R4904 T5845 T5844 arg1Of light,firefly
R4905 T5846 T5842 arg2Of units,of
R4906 T5846 T5843 arg2Of units,measured
R4907 T5846 T5845 arg1Of units,light
R4908 T5846 T5847 arg1Of units,(
R4909 T5846 T5850 arg1Of units,relative
R4910 T5848 T5847 arg2Of flu,(
R4911 T5849 T5847 arg3Of ),(
R4912 T5850 T5851 arg1Of relative,to
R4913 T5852 T5851 arg2Of renilla,to
R4914 T5852 T5853 arg1Of renilla,(
R4915 T5854 T5853 arg2Of rlu,(
R4916 T5855 T5853 arg3Of ),(
R4917 T5857 T5856 arg1Of experiment,Each
R4918 T5857 T5858 arg1Of experiment,was
R4919 T5857 T5859 arg2Of experiment,carried
R4920 T5859 T5858 arg2Of carried,was
R4921 T5859 T5860 arg1Of carried,out
R4922 T5859 T5864 arg1Of carried,times
R4923 T5863 T5861 arg1Of three,at
R4924 T5863 T5862 arg1Of three,least
R4925 T5864 T5863 arg1Of times,three
R5176 T6221 T6222 arg1Of Absence,of
R5177 T6221 T6228 arg1Of Absence,is
R5178 T6221 T6230 arg1Of Absence,due
R5179 T6224 T6222 arg2Of expression,of
R5180 T6224 T6223 arg1Of expression,IRF-4
R5181 T6224 T6225 arg1Of expression,in
R5182 T6227 T6225 arg2Of cells,in
R5183 T6227 T6226 arg1Of cells,leukemia
R5184 T6228 T6229 arg1Of is,not
R5185 T6230 T6228 arg2Of due,is
R5186 T6230 T6231 arg1Of due,to
R5187 T6233 T6231 arg2Of alterations,to
R5188 T6233 T6232 arg1Of alterations,promoter
R5189 T6234 T6235 arg1Of We,have
R5190 T6234 T6237 arg1Of We,demonstrated
R5191 T6237 T6235 arg2Of demonstrated,have
R5192 T6237 T6236 arg1Of demonstrated,previously
R5193 T6239 T6237 arg2Of lack,demonstrated
R5194 T6239 T6238 arg1Of lack,a
R5195 T6239 T6240 arg1Of lack,of
R5196 T6239 T6243 arg1Of lack,in
R5197 T6239 T6248 arg1Of lack,in
R5198 T6242 T6240 arg2Of expression,of
R5199 T6242 T6241 arg1Of expression,IRF-4
R5200 T6243 T6246 arg1Of in,and
R5201 T6245 T6243 arg2Of patients,in
R5202 T6245 T6244 arg1Of patients,leukemia
R5203 T6248 T6246 arg2Of in,and
R5204 T6248 T6247 arg1Of in,specifically
R5205 T6250 T6248 arg2Of T-cells,in
R5206 T6250 T6249 arg1Of T-cells,CML
R5207 T6250 T6251 arg1Of T-cells,(
R5208 T6252 T6251 arg2Of 3,(
R5209 T6253 T6251 arg3Of ),(
R5210 T6256 T6257 arg1Of we,demonstrate
R5211 T6257 T6254 arg1Of demonstrate,Here
R5212 T6257 T6255 arg1Of demonstrate,","
R5213 T6259 T6258 arg1Of absence,the
R5214 T6259 T6260 arg1Of absence,of
R5215 T6259 T6306 arg1Of absence,in
R5216 T6259 T6318 arg1Of absence,","
R5217 T6259 T6324 arg1Of absence,and
R5218 T6260 T6304 arg1Of of,but
R5219 T6262 T6260 arg2Of expression,of
R5220 T6262 T6261 arg1Of expression,IRF-4
R5221 T6262 T6263 arg1Of expression,in
R5222 T6262 T6278 arg1Of expression,","
R5223 T6262 T6289 arg1Of expression,","
R5224 T6262 T6291 arg1Of expression,","
R5225 T6267 T6263 arg2Of lines,in
R5226 T6267 T6264 arg1Of lines,various
R5227 T6267 T6265 arg1Of lines,hematopoietic
R5228 T6267 T6266 arg1Of lines,cell
R5229 T6267 T6268 arg1Of lines,","
R5230 T6267 T6270 arg1Of lines,as
R5231 T6270 T6269 arg1Of as,such
R5232 T6271 T6270 arg2Of Jurkat,as
R5233 T6271 T6272 arg1Of Jurkat,","
R5234 T6271 T6276 arg1Of Jurkat,","
R5235 T6275 T6272 arg2Of leukemia,","
R5236 T6275 T6273 arg1Of leukemia,a
R5237 T6275 T6274 arg1Of leukemia,T-cell
R5238 T6277 T6276 arg2Of CML-T1,","
R5239 T6282 T6278 arg2Of line,","
R5240 T6282 T6279 arg1Of line,a
R5241 T6282 T6280 arg1Of line,bcr-abl-positive
R5242 T6282 T6281 arg1Of line,T-cell
R5243 T6282 T6283 arg1Of line,","
R5244 T6282 T6285 arg1Of line,","
R5245 T6284 T6283 arg2Of K-562,","
R5246 T6288 T6285 arg2Of erythroleukemia,","
R5247 T6288 T6286 arg1Of erythroleukemia,a
R5248 T6288 T6287 arg1Of erythroleukemia,bcr-abl-positve
R5249 T6290 T6289 arg2Of U-937,","
R5250 T6294 T6295 arg1Of leukemia,","
R5251 T6295 T6297 arg1Of ",",and
R5252 T6296 T6295 arg2Of EM-2,","
R5253 T6297 T6293 arg1Of and,monocytic
R5254 T6297 T6299 arg1Of and,","
R5255 T6298 T6297 arg2Of LAMA-84,and
R5256 T6299 T6291 arg2Of ",",","
R5257 T6299 T6292 arg1Of ",",a
R5258 T6302 T6299 arg2Of leukemia,","
R5259 T6302 T6300 arg1Of leukemia,bcr-abl-positve
R5260 T6302 T6301 arg1Of leukemia,myeloid
R5261 T6304 T6303 arg1Of but,","
R5262 T6306 T6304 arg2Of in,but
R5263 T6306 T6305 arg1Of in,not
R5264 T6307 T6306 arg2Of SD-1,in
R5265 T6307 T6308 arg1Of SD-1,","
R5266 T6313 T6308 arg2Of leukemia,","
R5267 T6313 T6309 arg1Of leukemia,a
R5268 T6313 T6310 arg1Of leukemia,bcr-abl-positive
R5269 T6313 T6311 arg1Of leukemia,acute
R5270 T6313 T6312 arg1Of leukemia,lymphoblastic
R5271 T6313 T6314 arg1Of leukemia,(
R5272 T6316 T6314 arg2Of B-ALL,(
R5273 T6316 T6315 arg1Of B-ALL,pre
R5274 T6317 T6314 arg3Of ),(
R5275 T6319 T6318 arg2Of RPMI-8226,","
R5276 T6319 T6320 arg1Of RPMI-8226,","
R5277 T6323 T6320 arg2Of myeloma,","
R5278 T6323 T6321 arg1Of myeloma,a
R5279 T6323 T6322 arg1Of myeloma,multiple
R5280 T6324 T6257 arg2Of and,demonstrate
R5281 T6325 T6324 arg2Of BV-173,and
R5282 T6325 T6326 arg1Of BV-173,","
R5283 T6330 T6326 arg2Of line,","
R5284 T6330 T6327 arg1Of line,a
R5285 T6330 T6328 arg1Of line,bcr-abl-positive
R5286 T6330 T6329 arg1Of line,B-cell
R5287 T6330 T6331 arg1Of line,(
R5288 T6333 T6334 arg1Of 1A,and
R5289 T6334 T6331 arg2Of and,(
R5290 T6334 T6332 arg1Of and,Figures
R5291 T6335 T6334 arg2Of 5D,and
R5292 T6336 T6331 arg3Of ),(
R5293 T6338 T6337 arg2Of sequencing,After
R5294 T6338 T6339 arg1Of sequencing,of
R5295 T6342 T6339 arg2Of promoter,of
R5296 T6342 T6340 arg1Of promoter,the
R5297 T6342 T6341 arg1Of promoter,IRF-4
R5298 T6344 T6345 arg1Of it,could
R5299 T6344 T6346 arg1Of it,be
R5300 T6346 T6337 arg1Of be,After
R5301 T6346 T6343 arg1Of be,","
R5302 T6346 T6345 arg2Of be,could
R5303 T6346 T6353 arg1Of be,in
R5304 T6349 T6346 arg2Of absence,be
R5305 T6349 T6347 arg2Of absence,excluded
R5306 T6349 T6348 arg1Of absence,that
R5307 T6349 T6350 arg1Of absence,of
R5308 T6352 T6350 arg2Of expression,of
R5309 T6352 T6351 arg1Of expression,IRF-4
R5310 T6354 T6355 arg1Of any,of
R5311 T6354 T6360 arg1Of any,was
R5312 T6354 T6361 arg1Of any,due
R5313 T6359 T6355 arg2Of lines,of
R5314 T6359 T6356 arg1Of lines,the
R5315 T6359 T6357 arg1Of lines,above
R5316 T6359 T6358 arg1Of lines,cell
R5317 T6360 T6353 arg2Of was,in
R5318 T6361 T6360 arg2Of due,was
R5319 T6361 T6362 arg1Of due,to
R5320 T6364 T6362 arg2Of aberrations,to
R5321 T6364 T6363 arg1Of aberrations,genetic
R5322 T6369 T6367 arg1Of changes,2
R5323 T6369 T6368 arg1Of changes,bp
R5324 T6369 T6370 arg1Of changes,(
R5325 T6369 T6380 arg1Of changes,could
R5326 T6369 T6381 arg1Of changes,be
R5327 T6369 T6382 arg2Of changes,detected
R5328 T6372 T6371 arg1Of −1081,nucleotide
R5329 T6372 T6373 arg1Of −1081,","
R5330 T6373 T6375 arg1Of ",",and
R5331 T6374 T6373 arg2Of T→C,","
R5332 T6375 T6370 arg2Of and,(
R5333 T6375 T6377 arg1Of and,","
R5334 T6376 T6375 arg2Of −1068,and
R5335 T6378 T6377 arg2Of A→C,","
R5336 T6379 T6370 arg3Of ),(
R5337 T6382 T6365 arg1Of detected,However
R5338 T6382 T6366 arg1Of detected,","
R5339 T6382 T6380 arg2Of detected,could
R5340 T6382 T6381 arg2Of detected,be
R5341 T6382 T6383 arg1Of detected,in
R5342 T6387 T6385 arg1Of BV-173,the
R5343 T6387 T6386 arg1Of BV-173,IRF-4-positive
R5344 T6387 T6388 arg1Of BV-173,and
R5345 T6388 T6383 arg2Of and,in
R5346 T6388 T6384 arg1Of and,both
R5347 T6388 T6392 arg1Of and,","
R5348 T6391 T6388 arg2Of LAMA-84,and
R5349 T6391 T6389 arg1Of LAMA-84,the
R5350 T6391 T6390 arg1Of LAMA-84,IRF-4-negative
R5351 T6393 T6394 arg1Of EM-2,and
R5352 T6394 T6392 arg2Of and,","
R5353 T6394 T6396 arg1Of and,(
R5354 T6395 T6394 arg2Of K-562,and
R5355 T6398 T6396 arg2Of 1B,(
R5356 T6398 T6397 arg1Of 1B,Figure
R5357 T6399 T6396 arg3Of ),(
R5358 T6401 T6400 arg2Of position,At
R5359 T6401 T6402 arg1Of position,−116
R5360 T6405 T6403 arg1Of substitution,an
R5361 T6405 T6404 arg1Of substitution,A→C
R5362 T6405 T6406 arg1Of substitution,was
R5363 T6405 T6407 arg2Of substitution,found
R5364 T6407 T6400 arg1Of found,At
R5365 T6407 T6406 arg2Of found,was
R5366 T6407 T6408 arg1Of found,in
R5367 T6407 T6415 arg1Of found,whereas
R5368 T6409 T6410 arg1Of EM-2,","
R5369 T6410 T6412 arg1Of ",",and
R5370 T6411 T6410 arg2Of K-562,","
R5371 T6412 T6408 arg2Of and,in
R5372 T6413 T6412 arg2Of CML-T1,and
R5373 T6415 T6414 arg1Of whereas,","
R5374 T6416 T6417 arg1Of Jurkat,","
R5375 T6417 T6419 arg1Of ",",and
R5376 T6418 T6417 arg2Of BV-173,","
R5377 T6419 T6421 arg1Of and,exhibited
R5378 T6420 T6419 arg2Of SD-1,and
R5379 T6421 T6415 arg2Of exhibited,whereas
R5380 T6422 T6431 arg1Of a,RPMI-8226
R5381 T6425 T6423 arg2Of sequence,mixed
R5382 T6425 T6424 arg1Of sequence,A/C
R5383 T6425 T6426 arg1Of sequence,and
R5384 T6426 T6421 arg2Of and,exhibited
R5385 T6426 T6422 arg1Of and,a
R5386 T6426 T6434 arg1Of and,at
R5387 T6426 T6436 arg1Of and,(
R5388 T6427 T6428 arg1Of U-937,","
R5389 T6428 T6430 arg1Of ",",and
R5390 T6429 T6428 arg2Of LAMA-84,","
R5391 T6430 T6426 arg2Of and,and
R5392 T6431 T6430 arg2Of RPMI-8226,and
R5393 T6433 T6431 arg2Of substitution,RPMI-8226
R5394 T6433 T6432 arg1Of substitution,no
R5395 T6434 T6435 arg1Of at,all
R5396 T6438 T6436 arg2Of 1B,(
R5397 T6438 T6437 arg1Of 1B,Figure
R5398 T6439 T6436 arg3Of ),(
R5399 T6443 T6442 arg1Of alterations,these
R5400 T6443 T6444 arg1Of alterations,are
R5401 T6443 T6445 arg1Of alterations,unlikely
R5402 T6443 T6447 arg1Of alterations,affect
R5403 T6444 T6440 arg1Of are,Consequently
R5404 T6444 T6441 arg1Of are,","
R5405 T6445 T6444 arg2Of unlikely,are
R5406 T6447 T6445 arg2Of affect,unlikely
R5407 T6447 T6446 arg1Of affect,to
R5408 T6449 T6447 arg2Of expression,affect
R5409 T6449 T6448 arg1Of expression,IRF-4
R5814 T7025 T7026 arg1Of Increase,of
R5815 T7025 T7029 arg1Of Increase,in
R5816 T7025 T7032 arg1Of Increase,after
R5817 T7028 T7026 arg2Of expression,of
R5818 T7028 T7027 arg1Of expression,IRF-4
R5819 T7031 T7029 arg2Of cells,in
R5820 T7031 T7030 arg1Of cells,hematopoietic
R5821 T7033 T7032 arg2Of demethylating,after
R5822 T7034 T7033 arg2Of treatment,demethylating
R5823 T7035 T7037 arg1Of We,analyzed
R5824 T7037 T7036 arg1Of analyzed,next
R5825 T7040 T7039 arg1Of methylation,promoter
R5826 T7040 T7041 arg1Of methylation,could
R5827 T7040 T7042 arg1Of methylation,be
R5828 T7040 T7043 arg1Of methylation,responsible
R5829 T7042 T7037 arg2Of be,analyzed
R5830 T7042 T7038 arg1Of be,whether
R5831 T7042 T7041 arg2Of be,could
R5832 T7043 T7042 arg2Of responsible,be
R5833 T7043 T7044 arg1Of responsible,for
R5834 T7045 T7044 arg2Of down-regulation,for
R5835 T7045 T7046 arg1Of down-regulation,of
R5836 T7048 T7046 arg2Of expression,of
R5837 T7048 T7047 arg1Of expression,IRF-4
R5838 T7050 T7049 arg1Of region,A
R5839 T7050 T7051 arg1Of region,including
R5840 T7050 T7057 arg1Of region,exhibited
R5841 T7052 T7051 arg2Of exon1,including
R5842 T7052 T7053 arg1Of exon1,in
R5843 T7056 T7053 arg2Of promoter,in
R5844 T7056 T7054 arg1Of promoter,the
R5845 T7056 T7055 arg1Of promoter,IRF-4
R5846 T7060 T7057 arg2Of number,exhibited
R5847 T7060 T7058 arg1Of number,a
R5848 T7060 T7059 arg1Of number,large
R5849 T7060 T7061 arg1Of number,of
R5850 T7063 T7061 arg2Of sequences,of
R5851 T7063 T7062 arg1Of sequences,CpG-rich
R5852 T7063 T7064 arg1Of sequences,(
R5853 T7066 T7064 arg2Of 3A,(
R5854 T7066 T7065 arg1Of 3A,Figure
R5855 T7067 T7064 arg3Of ),(
R5856 T7070 T7068 arg1Of substances,Several
R5857 T7070 T7069 arg1Of substances,chemical
R5858 T7070 T7072 arg1Of substances,as
R5859 T7070 T7082 arg1Of substances,inhibit
R5860 T7070 T7091 arg1Of substances,can
R5861 T7070 T7092 arg1Of substances,be
R5862 T7070 T7093 arg2Of substances,used
R5863 T7072 T7071 arg1Of as,such
R5864 T7073 T7074 arg1Of 5-aza-2-deoxycytidine,(
R5865 T7073 T7077 arg1Of 5-aza-2-deoxycytidine,or
R5866 T7075 T7074 arg2Of AzadC,(
R5867 T7076 T7074 arg3Of ),(
R5868 T7077 T7072 arg2Of or,as
R5869 T7078 T7077 arg2Of 5-azacytidine,or
R5870 T7078 T7079 arg1Of 5-azacytidine,(
R5871 T7080 T7079 arg2Of AzaC,(
R5872 T7081 T7079 arg3Of ),(
R5873 T7082 T7089 arg1Of inhibit,and
R5874 T7084 T7083 arg1Of novo,de
R5875 T7087 T7082 arg2Of methylation,inhibit
R5876 T7087 T7084 arg1Of methylation,novo
R5877 T7087 T7085 arg1Of methylation,and
R5878 T7087 T7086 arg1Of methylation,maintenance
R5879 T7089 T7088 arg1Of and,","
R5880 T7093 T7089 arg2Of used,and
R5881 T7093 T7090 arg1Of used,thus
R5882 T7093 T7091 arg2Of used,can
R5883 T7093 T7092 arg2Of used,be
R5884 T7095 T7093 arg3Of discern,used
R5885 T7095 T7094 arg1Of discern,to
R5886 T7097 T7095 arg2Of methylation,discern
R5887 T7097 T7096 arg1Of methylation,promoter
R5888 T7097 T7098 arg1Of methylation,(
R5889 T7099 T7098 arg2Of "32,33",(
R5890 T7100 T7098 arg3Of ),(
R5891 T7101 T7102 arg1Of We,used
R5892 T7101 T7105 arg1Of We,generate
R5893 T7103 T7102 arg2Of AzadC,used
R5894 T7105 T7102 arg3Of generate,used
R5895 T7105 T7104 arg1Of generate,to
R5896 T7107 T7105 arg2Of DNA,generate
R5897 T7107 T7106 arg1Of DNA,unmethylated
R5898 T7111 T7108 arg1Of AzadC-treatment,A
R5899 T7111 T7109 arg1Of AzadC-treatment,72
R5900 T7111 T7110 arg1Of AzadC-treatment,h
R5901 T7111 T7112 arg1Of AzadC-treatment,resulted
R5902 T7112 T7113 arg1Of resulted,in
R5903 T7112 T7128 arg1Of resulted,in
R5904 T7113 T7127 arg1Of in,as
R5905 T7116 T7113 arg2Of activation,in
R5906 T7116 T7114 arg1Of activation,a
R5907 T7116 T7115 arg1Of activation,concentration-dependent
R5908 T7116 T7117 arg1Of activation,of
R5909 T7116 T7120 arg1Of activation,in
R5910 T7119 T7117 arg2Of transcription,of
R5911 T7119 T7118 arg1Of transcription,IRF-4
R5912 T7121 T7122 arg1Of Jurkat,and
R5913 T7123 T7122 arg2Of CML-T1,and
R5914 T7124 T7120 arg2Of T-cells,in
R5915 T7124 T7121 arg1Of T-cells,Jurkat
R5916 T7124 T7123 arg1Of T-cells,CML-T1
R5917 T7127 T7125 arg1Of as,as
R5918 T7127 T7126 arg1Of as,well
R5919 T7128 T7127 arg2Of in,as
R5920 T7129 T7130 arg1Of U-937,","
R5921 T7130 T7132 arg1Of ",",and
R5922 T7131 T7130 arg2Of K-562,","
R5923 T7132 T7128 arg2Of and,in
R5924 T7135 T7132 arg2Of lines,and
R5925 T7135 T7133 arg1Of lines,EM-2
R5926 T7135 T7134 arg1Of lines,cell
R5927 T7135 T7136 arg1Of lines,(
R5928 T7138 T7136 arg2Of 2A,(
R5929 T7138 T7137 arg1Of 2A,Figure
R5930 T7139 T7136 arg3Of ),(
R5931 T7141 T7140 arg1Of transcription,IRF-4
R5932 T7141 T7142 arg1Of transcription,was
R5933 T7141 T7143 arg2Of transcription,induced
R5934 T7141 T7149 arg1Of transcription,was
R5935 T7141 T7150 arg2Of transcription,observed
R5936 T7141 T7161 arg1Of transcription,increased
R5937 T7143 T7142 arg2Of induced,was
R5938 T7143 T7144 arg1Of induced,in
R5939 T7143 T7148 arg1Of induced,and
R5940 T7147 T7144 arg2Of manner,in
R5941 T7147 T7145 arg1Of manner,a
R5942 T7147 T7146 arg1Of manner,time-dependent
R5943 T7150 T7149 arg2Of observed,was
R5944 T7150 T7152 arg1Of observed,early
R5945 T7150 T7156 arg1Of observed,after
R5946 T7150 T7160 arg1Of observed,and
R5947 T7152 T7151 arg1Of early,as
R5948 T7152 T7153 arg1Of early,as
R5949 T7155 T7153 arg2Of h,as
R5950 T7155 T7154 arg1Of h,24
R5951 T7157 T7156 arg2Of treatment,after
R5952 T7157 T7158 arg1Of treatment,with
R5953 T7159 T7158 arg2Of AzadC,with
R5954 T7160 T7148 arg2Of and,and
R5955 T7161 T7160 arg2Of increased,and
R5956 T7161 T7162 arg1Of increased,over
R5957 T7161 T7164 arg1Of increased,until
R5958 T7163 T7162 arg2Of time,over
R5959 T7166 T7164 arg2Of h,until
R5960 T7166 T7165 arg1Of h,72
R5961 T7166 T7167 arg1Of h,(
R5962 T7169 T7167 arg2Of 2B,(
R5963 T7169 T7168 arg1Of 2B,Figure
R5964 T7170 T7167 arg3Of ),(
R5965 T7171 T7172 arg1Of Time,and
R5966 T7172 T7174 arg1Of and,of
R5967 T7172 T7180 arg1Of and,varied
R5968 T7173 T7172 arg2Of strength,and
R5969 T7176 T7174 arg2Of appearance,of
R5970 T7176 T7175 arg1Of appearance,the
R5971 T7176 T7177 arg1Of appearance,of
R5972 T7179 T7177 arg2Of transcripts,of
R5973 T7179 T7178 arg1Of transcripts,IRF-4
R5974 T7180 T7181 arg1Of varied,among
R5975 T7180 T7184 arg1Of varied,","
R5976 T7183 T7181 arg2Of lines,among
R5977 T7183 T7182 arg1Of lines,cell
R5978 T7186 T7185 arg1Of CML-T1,i.e.
R5979 T7186 T7187 arg1Of CML-T1,responded
R5980 T7187 T7184 arg2Of responded,","
R5981 T7187 T7189 arg1Of responded,to
R5982 T7188 T7187 arg2Of strongest,responded
R5983 T7190 T7189 arg2Of AzadC-treatment,to
R5984 T7190 T7191 arg1Of AzadC-treatment,(
R5985 T7192 T7191 arg2Of data,(
R5986 T7192 T7194 arg2Of data,shown
R5987 T7194 T7193 arg1Of shown,not
R5988 T7195 T7191 arg3Of ),(
R5989 T7197 T7196 arg2Of line,In
R5990 T7197 T7198 arg1Of line,with
R5991 T7199 T7198 arg2Of this,with
R5992 T7201 T7202 arg1Of AzadC-treatment,of
R5993 T7201 T7208 arg1Of AzadC-treatment,translated
R5994 T7203 T7204 arg1Of CML-T1,and
R5995 T7205 T7204 arg2Of LAMA-84,and
R5996 T7206 T7202 arg2Of cells,of
R5997 T7206 T7203 arg1Of cells,CML-T1
R5998 T7206 T7205 arg1Of cells,LAMA-84
R5999 T7208 T7196 arg1Of translated,In
R6000 T7208 T7200 arg1Of translated,","
R6001 T7208 T7207 arg1Of translated,also
R6002 T7208 T7209 arg1Of translated,in
R6003 T7211 T7209 arg2Of induction,in
R6004 T7211 T7210 arg1Of induction,an
R6005 T7211 T7212 arg1Of induction,of
R6006 T7215 T7212 arg2Of expression,of
R6007 T7215 T7213 arg1Of expression,IRF-4
R6008 T7215 T7214 arg1Of expression,protein
R6009 T7215 T7216 arg1Of expression,(
R6010 T7218 T7216 arg2Of 2C,(
R6011 T7218 T7217 arg1Of 2C,Figure
R6012 T7219 T7216 arg3Of ),(
R6013 T7222 T7223 arg1Of treatment,of
R6014 T7222 T7229 arg1Of treatment,","
R6015 T7228 T7223 arg2Of BV-173,of
R6016 T7228 T7224 arg1Of BV-173,the
R6017 T7228 T7225 arg1Of BV-173,IRF-4-positive
R6018 T7228 T7226 arg1Of BV-173,cell
R6019 T7228 T7227 arg1Of BV-173,line
R6020 T7229 T7235 arg1Of ",",had
R6021 T7230 T7231 arg1Of SD-1,and
R6022 T7231 T7229 arg2Of and,","
R6023 T7231 T7233 arg1Of and,with
R6024 T7232 T7231 arg2Of RPMI-8226,and
R6025 T7234 T7233 arg2Of AzadC,with
R6026 T7235 T7220 arg1Of had,Accordingly
R6027 T7235 T7221 arg1Of had,","
R6028 T7237 T7235 arg2Of effect,had
R6029 T7237 T7236 arg1Of effect,no
R6030 T7237 T7238 arg1Of effect,on
R6031 T7240 T7238 arg2Of expression,on
R6032 T7240 T7239 arg1Of expression,IRF-4
R6033 T7240 T7241 arg1Of expression,(
R6034 T7243 T7241 arg2Of 2D,(
R6035 T7243 T7242 arg1Of 2D,Figure
R6036 T7244 T7241 arg3Of ),(
R6037 T7245 T7246 arg1Of There,was
R6038 T7246 T7249 arg1Of was,in
R6039 T7246 T7256 arg1Of was,","
R6040 T7246 T7257 arg1Of was,as
R6041 T7248 T7246 arg2Of difference,was
R6042 T7248 T7247 arg1Of difference,no
R6043 T7251 T7249 arg2Of effects,in
R6044 T7251 T7250 arg1Of effects,the
R6045 T7251 T7252 arg1Of effects,of
R6046 T7253 T7252 arg2Of AzaC,of
R6047 T7253 T7254 arg1Of AzaC,versus
R6048 T7255 T7254 arg2Of AzadC,versus
R6049 T7258 T7259 arg1Of both,increased
R6050 T7259 T7257 arg2Of increased,as
R6051 T7259 T7267 arg1Of increased,as
R6052 T7263 T7259 arg2Of level,increased
R6053 T7263 T7260 arg1Of level,the
R6054 T7263 T7261 arg1Of level,IRF-4
R6055 T7263 T7262 arg1Of level,mRNA
R6056 T7263 T7264 arg1Of level,in
R6057 T7266 T7264 arg2Of cells,in
R6058 T7266 T7265 arg1Of cells,CML-T1
R6059 T7268 T7267 arg2Of well,as
R6060 T7268 T7269 arg1Of well,(
R6061 T7270 T7269 arg2Of data,(
R6062 T7270 T7272 arg2Of data,shown
R6063 T7272 T7271 arg1Of shown,not
R6064 T7273 T7269 arg3Of ),(
R6065 T7274 T7275 arg1Of This,implied
R6066 T7278 T7277 arg1Of methylation,promoter
R6067 T7278 T7279 arg1Of methylation,may
R6068 T7278 T7280 arg1Of methylation,control
R6069 T7280 T7279 arg2Of control,may
R6070 T7280 T7284 arg1Of control,but
R6071 T7282 T7280 arg2Of expression,control
R6072 T7282 T7281 arg1Of expression,IRF-4
R6073 T7284 T7275 arg2Of but,implied
R6074 T7284 T7276 arg1Of but,that
R6075 T7284 T7283 arg1Of but,","
R6076 T7287 T7285 arg1Of explanation,an
R6077 T7287 T7286 arg1Of explanation,alternative
R6078 T7287 T7288 arg1Of explanation,may
R6079 T7287 T7289 arg1Of explanation,be
R6080 T7289 T7284 arg2Of be,but
R6081 T7289 T7288 arg2Of be,may
R6082 T7289 T7297 arg1Of be,by
R6083 T7290 T7289 arg2Of activation,be
R6084 T7290 T7291 arg1Of activation,of
R6085 T7294 T7291 arg2Of regulators,of
R6086 T7294 T7292 arg1Of regulators,positive
R6087 T7294 T7293 arg1Of regulators,transcriptional
R6088 T7294 T7295 arg1Of regulators,of
R6089 T7296 T7295 arg2Of IRF-4,of
R6090 T7298 T7297 arg2Of AzadC,by
R6091 T7298 T7299 arg1Of AzadC,(
R6092 T7301 T7299 arg2Of AzaC,(
R6093 T7301 T7300 arg1Of AzaC,or
R6094 T7302 T7299 arg3Of ),(
R6497 T7853 T7852 arg1Of enzymes,Methylation-sensitive
R6498 T7853 T7854 arg1Of enzymes,do
R6499 T7853 T7856 arg1Of enzymes,cut
R6500 T7856 T7854 arg2Of cut,do
R6501 T7856 T7855 arg1Of cut,not
R6502 T7858 T7856 arg2Of sites,cut
R6503 T7858 T7857 arg1Of sites,specific
R6504 T7858 T7859 arg1Of sites,in
R6505 T7862 T7859 arg2Of promoter,in
R6506 T7862 T7860 arg1Of promoter,the
R6507 T7862 T7861 arg1Of promoter,IRF-4
R6508 T7862 T7863 arg1Of promoter,in
R6509 T7865 T7863 arg2Of cells,in
R6510 T7865 T7864 arg1Of cells,hematopoietic
R6511 T7868 T7866 arg1Of investigate,To
R6512 T7868 T7867 arg1Of investigate,further
R6513 T7868 T7871 arg1Of investigate,as
R6514 T7870 T7868 arg2Of methylation,investigate
R6515 T7870 T7869 arg1Of methylation,promoter
R6516 T7874 T7871 arg2Of mechanism,as
R6517 T7874 T7872 arg1Of mechanism,a
R6518 T7874 T7873 arg1Of mechanism,regulatory
R6519 T7874 T7875 arg1Of mechanism,of
R6520 T7878 T7875 arg2Of expression,of
R6521 T7878 T7876 arg1Of expression,IRF-4
R6522 T7878 T7877 arg1Of expression,gene
R6523 T7880 T7868 arg1Of restriction-PCR-assays,investigate
R6524 T7880 T7881 arg1Of restriction-PCR-assays,were
R6525 T7880 T7882 arg2Of restriction-PCR-assays,performed
R6526 T7882 T7866 modOf performed,To
R6527 T7882 T7879 arg1Of performed,","
R6528 T7882 T7881 arg2Of performed,were
R6529 T7882 T7883 arg1Of performed,(
R6530 T7882 T7886 arg1Of performed,","
R6531 T7882 T7887 arg1Of performed,where
R6532 T7884 T7883 arg2Of "20,24",(
R6533 T7885 T7883 arg3Of ),(
R6534 T7890 T7888 arg1Of DNA,only
R6535 T7890 T7889 arg2Of DNA,methylated
R6536 T7890 T7891 arg1Of DNA,would
R6537 T7890 T7893 arg1Of DNA,be
R6538 T7890 T7894 arg2Of DNA,cut
R6539 T7890 T7895 arg1Of DNA,enabling
R6540 T7894 T7887 arg2Of cut,where
R6541 T7894 T7891 arg2Of cut,would
R6542 T7894 T7892 arg1Of cut,not
R6543 T7894 T7893 arg2Of cut,be
R6544 T7894 T7895 modOf cut,enabling
R6545 T7898 T7896 arg1Of amplification,subsequent
R6546 T7898 T7897 arg1Of amplification,PCR
R6547 T7898 T7899 arg1Of amplification,and
R6548 T7899 T7895 arg2Of and,enabling
R6549 T7901 T7899 arg2Of versa,and
R6550 T7901 T7900 arg1Of versa,vice
R6551 T7903 T7902 arg1Of DNA,Genomic
R6552 T7903 T7904 arg1Of DNA,from
R6553 T7903 T7918 arg1Of DNA,was
R6554 T7903 T7919 arg2Of DNA,digested
R6555 T7906 T7905 arg1Of cells,leukemic
R6556 T7907 T7908 arg1Of Jurkat,","
R6557 T7908 T7910 arg1Of ",",","
R6558 T7909 T7908 arg2Of CML-T1,","
R6559 T7910 T7912 arg1Of ",",","
R6560 T7911 T7910 arg2Of U-937,","
R6561 T7912 T7914 arg1Of ",",","
R6562 T7913 T7912 arg2Of K-562,","
R6563 T7914 T7906 arg1Of ",",cells
R6564 T7914 T7916 arg1Of ",",and
R6565 T7915 T7914 arg2Of EM-2,","
R6566 T7916 T7904 arg2Of and,from
R6567 T7917 T7916 arg2Of BV-173,and
R6568 T7919 T7918 arg2Of digested,was
R6569 T7919 T7920 arg1Of digested,with
R6570 T7923 T7921 arg1Of enzymes,the
R6571 T7923 T7922 arg1Of enzymes,methylation-sensitive
R6572 T7924 T7925 arg1Of HpaII,","
R6573 T7925 T7927 arg1Of ",",and
R6574 T7926 T7925 arg2Of Bsh1236I,","
R6575 T7927 T7920 arg2Of and,with
R6576 T7927 T7923 arg1Of and,enzymes
R6577 T7929 T7927 arg2Of Bsp143II,and
R6578 T7929 T7928 arg1Of Bsp143II,HaeII-isochizomer
R6579 T7930 T7931 arg1Of EcoRI,","
R6580 T7930 T7932 arg1Of EcoRI,which
R6581 T7930 T7933 arg1Of EcoRI,has
R6582 T7936 T7934 arg1Of site,no
R6583 T7936 T7935 arg1Of site,recognition
R6584 T7936 T7937 arg1Of site,within
R6585 T7936 T7942 arg1Of site,and
R6586 T7940 T7937 arg2Of promoter,within
R6587 T7940 T7938 arg1Of promoter,the
R6588 T7940 T7939 arg1Of promoter,IRF-4
R6589 T7942 T7933 arg2Of and,has
R6590 T7942 T7941 arg1Of and,","
R6591 T7946 T7942 arg2Of MspI,and
R6592 T7946 T7943 arg1Of MspI,the
R6593 T7946 T7944 arg1Of MspI,methylation-resistant
R6594 T7946 T7945 arg1Of MspI,enzyme
R6595 T7946 T7947 arg2Of MspI,served
R6596 T7947 T7948 arg1Of served,as
R6597 T7949 T7948 arg2Of controls,as
R6598 T7953 T7950 arg1Of reactions,Two
R6599 T7953 T7951 arg1Of reactions,separate
R6600 T7953 T7952 arg1Of reactions,amplification
R6601 T7953 T7954 arg1Of reactions,were
R6602 T7953 T7955 arg2Of reactions,performed
R6603 T7955 T7954 arg2Of performed,were
R6604 T7955 T7956 arg1Of performed,","
R6605 T7955 T7957 modOf performed,generating
R6606 T7959 T7957 arg2Of fragments,generating
R6607 T7959 T7958 arg1Of fragments,two
R6608 T7959 T7960 arg1Of fragments,","
R6609 T7961 T7962 arg1Of F1,and
R6610 T7962 T7960 arg2Of and,","
R6611 T7962 T7964 arg1Of and,(
R6612 T7963 T7962 arg2Of F2,and
R6613 T7966 T7964 arg2Of 3A,(
R6614 T7966 T7965 arg1Of 3A,Figure
R6615 T7967 T7964 arg3Of ),(
R6616 T7969 T7968 arg2Of digestion,After
R6617 T7969 T7970 arg1Of digestion,with
R6618 T7971 T7972 arg1Of HpaII,and
R6619 T7972 T7970 arg2Of and,with
R6620 T7973 T7972 arg2Of Bsp143II,and
R6621 T7977 T7974 arg1Of amplification,a
R6622 T7977 T7975 arg1Of amplification,sufficient
R6623 T7977 T7976 arg1Of amplification,PCR
R6624 T7977 T7978 arg1Of amplification,of
R6625 T7977 T7982 arg1Of amplification,was
R6626 T7977 T7983 arg2Of amplification,detected
R6627 T7979 T7980 arg1Of F1,and
R6628 T7980 T7978 arg2Of and,of
R6629 T7981 T7980 arg2Of F2,and
R6630 T7983 T7968 arg1Of detected,After
R6631 T7983 T7982 arg2Of detected,was
R6632 T7983 T7984 arg1Of detected,in
R6633 T7983 T7986 arg1Of detected,from
R6634 T7983 T7998 arg1Of detected,","
R6635 T7983 T7999 modOf detected,suggesting
R6636 T7985 T7984 arg2Of DNA,in
R6637 T7988 T7987 arg1Of Jurkat,IRF-4-negative
R6638 T7988 T7989 arg1Of Jurkat,","
R6639 T7989 T7991 arg1Of ",",","
R6640 T7990 T7989 arg2Of CML-T1,","
R6641 T7991 T7993 arg1Of ",",","
R6642 T7992 T7991 arg2Of U-937,","
R6643 T7993 T7995 arg1Of ",",and
R6644 T7994 T7993 arg2Of K-562,","
R6645 T7995 T7986 arg2Of and,from
R6646 T7997 T7995 arg2Of cells,and
R6647 T7997 T7996 arg1Of cells,EM-2
R6648 T8002 T7999 arg2Of methylation,suggesting
R6649 T8002 T8000 arg1Of methylation,a
R6650 T8002 T8001 arg1Of methylation,promoter
R6651 T8002 T8003 arg1Of methylation,(
R6652 T8002 T8008 arg1Of methylation,at
R6653 T8006 T8003 arg2Of protection,(
R6654 T8006 T8004 arg1Of protection,and
R6655 T8006 T8005 arg1Of protection,restriction
R6656 T8007 T8003 arg3Of ),(
R6657 T8012 T8008 arg2Of sites,at
R6658 T8012 T8009 arg1Of sites,the
R6659 T8012 T8010 arg1Of sites,respective
R6660 T8012 T8011 arg1Of sites,recognition
R6661 T8012 T8013 arg1Of sites,(
R6662 T8015 T8014 arg1Of 3B,Figure
R6663 T8015 T8016 arg1Of 3B,and
R6664 T8016 T8013 arg2Of and,(
R6665 T8017 T8016 arg2Of C,and
R6666 T8018 T8013 arg3Of ),(
R6667 T8024 T8021 arg2Of cells,in
R6668 T8024 T8022 arg1Of cells,IRF-4-positive
R6669 T8024 T8023 arg1Of cells,SD-1
R6670 T8025 T8026 arg1Of digestion,with
R6671 T8025 T8031 arg1Of digestion,inhibited
R6672 T8029 T8026 arg2Of enzymes,with
R6673 T8029 T8027 arg1Of enzymes,the
R6674 T8029 T8028 arg1Of enzymes,methylation-sensitive
R6675 T8031 T8019 arg1Of inhibited,Notably
R6676 T8031 T8020 arg1Of inhibited,","
R6677 T8031 T8021 arg1Of inhibited,in
R6678 T8031 T8030 arg1Of inhibited,completely
R6679 T8032 T8031 arg2Of amplification,inhibited
R6680 T8032 T8033 arg1Of amplification,of
R6681 T8034 T8035 arg1Of F1,and
R6682 T8035 T8033 arg2Of and,of
R6683 T8036 T8035 arg2Of F2,and
R6684 T8040 T8037 arg2Of cells,In
R6685 T8040 T8038 arg1Of cells,IRF-4-positive
R6686 T8040 T8039 arg1Of cells,BV-173
R6687 T8042 T8041 arg1Of HpaII,a
R6688 T8042 T8044 arg1Of HpaII,but
R6689 T8044 T8043 arg1Of but,","
R6690 T8044 T8045 arg1Of but,not
R6691 T8044 T8051 arg1Of but,reduced
R6692 T8048 T8044 arg2Of digestion,but
R6693 T8048 T8046 arg1Of digestion,a
R6694 T8048 T8047 arg1Of digestion,Bsh1236I
R6695 T8051 T8049 arg1Of reduced,","
R6696 T8051 T8050 arg1Of reduced,significantly
R6697 T8051 T8063 arg1Of reduced,whereas
R6698 T8055 T8051 arg2Of message,reduced
R6699 T8055 T8052 arg1Of message,the
R6700 T8055 T8053 arg1Of message,amplifiable
R6701 T8055 T8054 arg1Of message,DNA
R6702 T8055 T8056 arg1Of message,of
R6703 T8057 T8056 arg2Of F2,of
R6704 T8057 T8058 arg1Of F2,(
R6705 T8060 T8058 arg2Of 3C,(
R6706 T8060 T8059 arg1Of 3C,Figure
R6707 T8061 T8058 arg3Of ),(
R6708 T8063 T8037 arg1Of whereas,In
R6709 T8063 T8062 arg1Of whereas,","
R6710 T8064 T8065 arg1Of amplification,of
R6711 T8064 T8067 arg1Of amplification,was
R6712 T8064 T8069 arg2Of amplification,affected
R6713 T8066 T8065 arg2Of F1,of
R6714 T8069 T8063 arg2Of affected,whereas
R6715 T8069 T8067 arg2Of affected,was
R6716 T8069 T8068 arg1Of affected,not
R6717 T8069 T8070 arg1Of affected,(
R6718 T8072 T8070 arg2Of 3B,(
R6719 T8072 T8071 arg1Of 3B,Figure
R6720 T8073 T8070 arg3Of ),(
R6721 T8074 T8075 arg1Of This,implied
R6722 T8078 T8077 arg1Of transcription,IRF-4
R6723 T8078 T8079 arg1Of transcription,in
R6724 T8078 T8084 arg1Of transcription,is
R6725 T8078 T8085 arg2Of transcription,associated
R6726 T8080 T8081 arg1Of SD-1,and
R6727 T8082 T8081 arg2Of BV-173,and
R6728 T8083 T8079 arg2Of cells,in
R6729 T8083 T8080 arg1Of cells,SD-1
R6730 T8083 T8082 arg1Of cells,BV-173
R6731 T8085 T8075 arg2Of associated,implied
R6732 T8085 T8076 arg1Of associated,that
R6733 T8085 T8084 arg2Of associated,is
R6734 T8085 T8086 arg1Of associated,with
R6735 T8085 T8090 arg1Of associated,(
R6736 T8085 T8098 arg1Of associated,as
R6737 T8089 T8086 arg2Of methylation,with
R6738 T8089 T8087 arg1Of methylation,less
R6739 T8089 T8088 arg1Of methylation,promoter
R6740 T8091 T8090 arg2Of in,(
R6741 T8092 T8091 arg2Of BV-173,in
R6742 T8092 T8094 arg1Of BV-173,at
R6743 T8094 T8093 arg1Of at,especially
R6744 T8096 T8094 arg2Of sites,at
R6745 T8096 T8095 arg1Of sites,HpaII
R6746 T8097 T8090 arg3Of ),(
R6747 T8099 T8098 arg2Of compared,as
R6748 T8099 T8100 arg1Of compared,with
R6749 T8104 T8100 arg2Of cells,with
R6750 T8104 T8101 arg1Of cells,the
R6751 T8104 T8102 arg2Of cells,tested
R6752 T8104 T8103 arg1Of cells,IRF-4-negative
R7082 T8580 T8578 arg1Of sites,Specific
R7083 T8580 T8579 arg1Of sites,CpG
R7084 T8580 T8581 arg1Of sites,in
R7085 T8580 T8585 arg1Of sites,are
R7086 T8580 T8586 arg2Of sites,methylated
R7087 T8584 T8581 arg2Of promoter,in
R7088 T8584 T8582 arg1Of promoter,the
R7089 T8584 T8583 arg1Of promoter,IRF-4
R7090 T8586 T8585 arg2Of methylated,are
R7091 T8586 T8587 arg1Of methylated,in
R7092 T8589 T8587 arg2Of cells,in
R7093 T8589 T8588 arg1Of cells,hematopoietic
R7094 T8591 T8590 arg2Of order,In
R7095 T8594 T8590 arg3Of map,In
R7096 T8594 T8592 arg1Of map,to
R7097 T8594 T8593 arg1Of map,exactly
R7098 T8597 T8594 arg2Of sites,map
R7099 T8597 T8595 arg1Of sites,the
R7100 T8597 T8596 arg1Of sites,methylation
R7101 T8597 T8598 arg1Of sites,within
R7102 T8601 T8598 arg2Of promoter,within
R7103 T8601 T8599 arg1Of promoter,the
R7104 T8601 T8600 arg1Of promoter,IRF-4
R7105 T8603 T8594 arg1Of we,map
R7106 T8603 T8604 arg1Of we,treated
R7107 T8604 T8590 arg1Of treated,In
R7108 T8604 T8602 arg1Of treated,","
R7109 T8604 T8638 arg1Of treated,","
R7110 T8604 T8639 arg1Of treated,whereas
R7111 T8605 T8604 arg2Of DNA,treated
R7112 T8605 T8606 arg1Of DNA,of
R7113 T8605 T8620 arg1Of DNA,of
R7114 T8606 T8619 arg1Of of,as
R7115 T8607 T8608 arg1Of Jurkat,","
R7116 T8608 T8610 arg1Of ",",","
R7117 T8609 T8608 arg2Of CML-T1,","
R7118 T8610 T8612 arg1Of ",",","
R7119 T8611 T8610 arg2Of U-937,","
R7120 T8612 T8614 arg1Of ",",and
R7121 T8613 T8612 arg2Of K-562,","
R7122 T8615 T8614 arg2Of EM-2,and
R7123 T8616 T8606 arg2Of cells,of
R7124 T8616 T8607 arg1Of cells,Jurkat
R7125 T8616 T8609 arg1Of cells,CML-T1
R7126 T8616 T8611 arg1Of cells,U-937
R7127 T8616 T8613 arg1Of cells,K-562
R7128 T8616 T8615 arg1Of cells,EM-2
R7129 T8619 T8617 arg1Of as,as
R7130 T8619 T8618 arg1Of as,well
R7131 T8620 T8619 arg2Of of,as
R7132 T8621 T8622 arg1Of SD-1,","
R7133 T8622 T8624 arg1Of ",",and
R7134 T8623 T8622 arg2Of RPMI-8226,","
R7135 T8624 T8620 arg2Of and,of
R7136 T8624 T8628 arg1Of and,with
R7137 T8624 T8630 arg1Of and,","
R7138 T8624 T8631 arg1Of and,which
R7139 T8624 T8633 arg1Of and,converts
R7140 T8627 T8624 arg2Of cells,and
R7141 T8627 T8625 arg1Of cells,BV-173
R7142 T8627 T8626 arg1Of cells,control
R7143 T8629 T8628 arg2Of bisulfite,with
R7144 T8633 T8632 arg1Of converts,chemically
R7145 T8633 T8636 arg1Of converts,to
R7146 T8635 T8633 arg2Of cytosine,converts
R7147 T8635 T8634 arg1Of cytosine,unmethylated
R7148 T8637 T8636 arg2Of uracil,to
R7149 T8640 T8641 arg1Of it,has
R7150 T8641 T8639 arg2Of has,whereas
R7151 T8641 T8644 arg1Of has,on
R7152 T8641 T8647 arg1Of has,","
R7153 T8641 T8648 arg1Of has,i.e.
R7154 T8641 T8649 arg1Of has,in
R7155 T8643 T8641 arg2Of effect,has
R7156 T8643 T8642 arg1Of effect,no
R7157 T8646 T8644 arg2Of cytosine,on
R7158 T8646 T8645 arg2Of cytosine,methylated
R7159 T8650 T8649 arg2Of CpG,in
R7160 T8650 T8651 arg1Of CpG,(
R7161 T8652 T8651 arg2Of 34,(
R7162 T8653 T8651 arg3Of ),(
R7163 T8655 T8654 arg1Of technique,This
R7164 T8655 T8656 arg1Of technique,is
R7165 T8655 T8658 arg1Of technique,useful
R7166 T8658 T8656 arg2Of useful,is
R7167 T8658 T8657 arg1Of useful,especially
R7168 T8658 T8659 arg1Of useful,for
R7169 T8660 T8659 arg2Of detection,for
R7170 T8660 T8661 arg1Of detection,of
R7171 T8664 T8661 arg2Of patterns,of
R7172 T8664 T8662 arg1Of patterns,unknown
R7173 T8664 T8663 arg1Of patterns,methylation
R7174 T8666 T8665 arg1Of amplification,PCR
R7175 T8666 T8667 arg1Of amplification,","
R7176 T8667 T8669 arg1Of ",",and
R7177 T8668 T8667 arg2Of cloning,","
R7178 T8669 T8671 arg1Of and,of
R7179 T8669 T8675 arg1Of and,showed
R7180 T8670 T8669 arg2Of sequencing,and
R7181 T8674 T8671 arg2Of DNA,of
R7182 T8674 T8672 arg1Of DNA,the
R7183 T8674 T8673 arg1Of DNA,bisulfite-treated
R7184 T8679 T8675 arg2Of pattern,showed
R7185 T8679 T8676 arg1Of pattern,a
R7186 T8679 T8677 arg1Of pattern,specific
R7187 T8679 T8678 arg1Of pattern,methylation
R7188 T8679 T8680 arg1Of pattern,of
R7189 T8679 T8686 arg1Of pattern,in
R7190 T8685 T8680 arg2Of sites,of
R7191 T8685 T8681 arg1Of sites,the
R7192 T8685 T8682 arg2Of sites,analyzed
R7193 T8685 T8683 arg1Of sites,62
R7194 T8685 T8684 arg1Of sites,CpG
R7195 T8689 T8686 arg2Of lines,in
R7196 T8689 T8687 arg1Of lines,all
R7197 T8689 T8688 arg1Of lines,cell
R7198 T8689 T8690 arg1Of lines,(
R7199 T8691 T8692 arg1Of Figure,4
R7200 T8691 T8693 arg1Of Figure,and
R7201 T8693 T8690 arg2Of and,(
R7202 T8694 T8693 arg2Of Table,and
R7203 T8694 T8695 arg1Of Table,1
R7204 T8696 T8690 arg3Of ),(
R7205 T8698 T8697 arg2Of general,In
R7206 T8702 T8700 arg1Of status,the
R7207 T8702 T8701 arg1Of status,methylational
R7208 T8702 T8703 arg1Of status,ranged
R7209 T8703 T8697 arg1Of ranged,In
R7210 T8703 T8699 arg1Of ranged,","
R7211 T8703 T8704 arg1Of ranged,from
R7212 T8707 T8704 arg2Of line,from
R7213 T8707 T8705 arg1Of line,one
R7214 T8707 T8706 arg1Of line,cell
R7215 T8707 T8708 arg1Of line,with
R7216 T8711 T8710 arg1Of non-methylated,nearly
R7217 T8713 T8708 arg2Of promoter,with
R7218 T8713 T8709 arg1Of promoter,a
R7219 T8713 T8711 arg1Of promoter,non-methylated
R7220 T8713 T8712 arg1Of promoter,IRF-4
R7221 T8713 T8714 arg1Of promoter,(
R7222 T8713 T8719 arg1Of promoter,to
R7223 T8715 T8714 arg2Of SD-1,(
R7224 T8715 T8716 arg1Of SD-1,","
R7225 T8717 T8716 arg2Of IRF-4-positive,","
R7226 T8718 T8714 arg3Of ),(
R7227 T8722 T8721 arg1Of methylated,completely
R7228 T8724 T8719 arg2Of promoter,to
R7229 T8724 T8720 arg1Of promoter,a
R7230 T8724 T8722 arg1Of promoter,methylated
R7231 T8724 T8723 arg1Of promoter,IRF-4
R7232 T8724 T8725 arg1Of promoter,in
R7233 T8726 T8725 arg2Of CML-T1,in
R7234 T8726 T8727 arg1Of CML-T1,(
R7235 T8728 T8727 arg2Of IRF-4-negative,(
R7236 T8729 T8727 arg3Of ),(
R7237 T8733 T8732 arg1Of percentage,the
R7238 T8733 T8734 arg1Of percentage,of
R7239 T8733 T8737 arg1Of percentage,in
R7240 T8733 T8744 arg1Of percentage,was
R7241 T8733 T8746 arg1Of percentage,low
R7242 T8736 T8734 arg2Of methylation,of
R7243 T8736 T8735 arg1Of methylation,CpG
R7244 T8740 T8737 arg2Of promoter,in
R7245 T8740 T8738 arg1Of promoter,the
R7246 T8740 T8739 arg1Of promoter,IRF-4
R7247 T8740 T8741 arg1Of promoter,from
R7248 T8743 T8741 arg2Of cells,from
R7249 T8743 T8742 arg1Of cells,IRF-4-positive
R7250 T8744 T8730 arg1Of was,Interestingly
R7251 T8744 T8731 arg1Of was,","
R7252 T8746 T8744 arg2Of low,was
R7253 T8746 T8745 arg1Of low,very
R7254 T8746 T8747 arg1Of low,(
R7255 T8750 T8747 arg2Of %,(
R7256 T8750 T8748 arg1Of %,mean
R7257 T8750 T8749 arg1Of %,24
R7258 T8751 T8747 arg3Of ),(
R7259 T8752 T8744 arg3Of as,was
R7260 T8753 T8752 arg2Of compared,as
R7261 T8753 T8754 arg1Of compared,with
R7262 T8756 T8754 arg2Of cells,with
R7263 T8756 T8755 arg1Of cells,IRF-4-negative
R7264 T8756 T8757 arg1Of cells,(
R7265 T8756 T8762 arg1Of cells,(
R7266 T8760 T8757 arg2Of %,(
R7267 T8760 T8758 arg1Of %,mean
R7268 T8760 T8759 arg1Of %,94
R7269 T8761 T8757 arg3Of ),(
R7270 T8764 T8763 arg1Of 4A,Figure
R7271 T8764 T8765 arg1Of 4A,and
R7272 T8765 T8762 arg2Of and,(
R7273 T8767 T8765 arg2Of 1,and
R7274 T8767 T8766 arg1Of 1,Table
R7275 T8768 T8762 arg3Of ),(
R7276 T8770 T8769 arg1Of 5′-region,A
R7277 T8770 T8771 arg1Of 5′-region,(
R7278 T8770 T8774 arg1Of 5′-region,with
R7279 T8770 T8794 arg1Of 5′-region,was
R7280 T8770 T8795 arg2Of 5′-region,found
R7281 T8772 T8771 arg2Of R1,(
R7282 T8773 T8771 arg3Of ),(
R7283 T8778 T8774 arg2Of sites,with
R7284 T8778 T8775 arg1Of sites,13
R7285 T8778 T8776 arg2Of sites,hypermethylated
R7286 T8778 T8777 arg1Of sites,CpG
R7287 T8778 T8779 arg1Of sites,(
R7288 T8781 T8779 arg2Of number,(
R7289 T8781 T8780 arg1Of number,mean
R7290 T8781 T8782 arg1Of number,of
R7291 T8781 T8785 arg1Of number,5.5
R7292 T8784 T8782 arg2Of clones,of
R7293 T8784 T8783 arg2Of clones,methylated
R7294 T8785 T8786 arg1Of 5.5,of
R7295 T8785 T8788 arg1Of 5.5,with
R7296 T8787 T8786 arg2Of 8,of
R7297 T8789 T8790 arg1Of 77,%
R7298 T8792 T8788 arg2Of CpGs,with
R7299 T8792 T8789 arg1Of CpGs,77
R7300 T8792 T8791 arg2Of CpGs,methylated
R7301 T8793 T8779 arg3Of ),(
R7302 T8795 T8794 arg2Of found,was
R7303 T8795 T8796 arg1Of found,in
R7304 T8795 T8799 arg1Of found,(
R7305 T8795 T8805 arg1Of found,and
R7306 T8798 T8796 arg2Of cells,in
R7307 T8798 T8797 arg1Of cells,most
R7308 T8800 T8799 arg2Of except,(
R7309 T8801 T8802 arg1Of SD-1,and
R7310 T8802 T8800 arg2Of and,except
R7311 T8803 T8802 arg2Of RPMI-8226,and
R7312 T8804 T8799 arg3Of ),(
R7313 T8807 T8806 arg1Of 3′-region,a
R7314 T8807 T8808 arg1Of 3′-region,(
R7315 T8807 T8811 arg1Of 3′-region,of
R7316 T8807 T8831 arg1Of 3′-region,was
R7317 T8807 T8832 arg2Of 3′-region,found
R7318 T8809 T8808 arg2Of R3,(
R7319 T8810 T8808 arg3Of ),(
R7320 T8815 T8811 arg2Of sites,of
R7321 T8815 T8812 arg1Of sites,6
R7322 T8815 T8813 arg2Of sites,hypomethylated
R7323 T8815 T8814 arg1Of sites,CpG
R7324 T8815 T8816 arg1Of sites,(
R7325 T8818 T8816 arg2Of number,(
R7326 T8818 T8817 arg1Of number,mean
R7327 T8818 T8819 arg1Of number,of
R7328 T8818 T8822 arg1Of number,1.7
R7329 T8821 T8819 arg2Of clones,of
R7330 T8821 T8820 arg2Of clones,methylated
R7331 T8822 T8823 arg1Of 1.7,of
R7332 T8822 T8825 arg1Of 1.7,with
R7333 T8824 T8823 arg2Of 8,of
R7334 T8826 T8827 arg1Of 33,%
R7335 T8829 T8825 arg2Of CpGs,with
R7336 T8829 T8826 arg1Of CpGs,33
R7337 T8829 T8828 arg2Of CpGs,methylated
R7338 T8830 T8816 arg3Of ),(
R7339 T8832 T8805 arg2Of found,and
R7340 T8832 T8831 arg2Of found,was
R7341 T8832 T8833 arg1Of found,in
R7342 T8835 T8833 arg2Of cells,in
R7343 T8835 T8834 arg1Of cells,most
R7344 T8835 T8836 arg1Of cells,(
R7345 T8835 T8842 arg1Of cells,(
R7346 T8837 T8836 arg2Of except,(
R7347 T8838 T8839 arg1Of CML-T1,and
R7348 T8839 T8837 arg2Of and,except
R7349 T8840 T8839 arg2Of U-937,and
R7350 T8841 T8836 arg3Of ),(
R7351 T8844 T8843 arg1Of 4A,Figure
R7352 T8844 T8845 arg1Of 4A,and
R7353 T8845 T8842 arg2Of and,(
R7354 T8847 T8845 arg2Of 1,and
R7355 T8847 T8846 arg1Of 1,Table
R7356 T8848 T8842 arg3Of ),(
R7357 T8852 T8851 arg1Of stretch,a
R7358 T8852 T8853 arg1Of stretch,of
R7359 T8852 T8863 arg1Of stretch,was
R7360 T8852 T8864 arg2Of stretch,detected
R7361 T8856 T8853 arg2Of sites,of
R7362 T8856 T8854 arg1Of sites,13
R7363 T8856 T8855 arg1Of sites,CpG
R7364 T8856 T8857 arg1Of sites,(
R7365 T8859 T8857 arg2Of 10–22,(
R7366 T8859 T8858 arg1Of 10–22,#
R7367 T8859 T8860 arg1Of 10–22,;
R7368 T8861 T8860 arg2Of R2,;
R7369 T8862 T8857 arg3Of ),(
R7370 T8864 T8849 arg1Of detected,Intriguingly
R7371 T8864 T8850 arg1Of detected,","
R7372 T8864 T8863 arg2Of detected,was
R7373 T8864 T8865 arg1Of detected,in
R7374 T8864 T8866 arg1Of detected,between
R7375 T8868 T8866 arg2Of regions,between
R7376 T8868 T8867 arg1Of regions,these
R7377 T8868 T8869 arg1Of regions,","
R7378 T8868 T8870 arg1Of regions,which
R7379 T8868 T8871 arg1Of regions,were
R7380 T8868 T8873 arg2Of regions,methylated
R7381 T8868 T8893 arg1Of regions,non-methylated
R7382 T8873 T8872 arg1Of methylated,highly
R7383 T8873 T8874 arg1Of methylated,in
R7384 T8873 T8891 arg1Of methylated,but
R7385 T8875 T8874 arg2Of IRF-4-negative,in
R7386 T8875 T8876 arg1Of IRF-4-negative,(
R7387 T8878 T8876 arg2Of number,(
R7388 T8878 T8877 arg1Of number,mean
R7389 T8878 T8879 arg1Of number,of
R7390 T8878 T8882 arg1Of number,7.1
R7391 T8881 T8879 arg2Of clones,of
R7392 T8881 T8880 arg2Of clones,methylated
R7393 T8882 T8883 arg1Of 7.1,of
R7394 T8882 T8885 arg1Of 7.1,with
R7395 T8884 T8883 arg2Of 8,of
R7396 T8886 T8887 arg1Of 89,%
R7397 T8889 T8885 arg2Of CpGs,with
R7398 T8889 T8886 arg1Of CpGs,89
R7399 T8889 T8888 arg2Of CpGs,methylated
R7400 T8890 T8876 arg3Of ),(
R7401 T8891 T8871 arg2Of but,were
R7402 T8893 T8891 arg2Of non-methylated,but
R7403 T8893 T8892 arg1Of non-methylated,totally
R7404 T8893 T8894 arg1Of non-methylated,in
R7405 T8896 T8894 arg2Of cells,in
R7406 T8896 T8895 arg1Of cells,IRF-4-positive
R7407 T8896 T8897 arg1Of cells,(
R7408 T8899 T8898 arg1Of 4A,Figure
R7409 T8899 T8900 arg1Of 4A,and
R7410 T8900 T8897 arg2Of and,(
R7411 T8901 T8900 arg2Of B,and
R7412 T8902 T8897 arg3Of ),(
R7413 T8907 T8905 arg1Of sites,three
R7414 T8907 T8906 arg1Of sites,CpG
R7415 T8907 T8908 arg1Of sites,at
R7416 T8907 T8912 arg1Of sites,(
R7417 T8907 T8920 arg1Of sites,and
R7418 T8911 T8908 arg2Of end,at
R7419 T8911 T8909 arg1Of end,the
R7420 T8911 T8910 arg1Of end,5′
R7421 T8914 T8915 arg1Of 54,","
R7422 T8915 T8912 arg2Of ",",(
R7423 T8915 T8913 arg1Of ",",#
R7424 T8915 T8917 arg1Of ",",","
R7425 T8916 T8915 arg2Of 56,","
R7426 T8918 T8917 arg2Of 58,","
R7427 T8919 T8912 arg3Of ),(
R7428 T8920 T8924 arg1Of and,at
R7429 T8920 T8928 arg1Of and,(
R7430 T8920 T8934 arg1Of and,showed
R7431 T8923 T8920 arg2Of motifs,and
R7432 T8923 T8921 arg1Of motifs,two
R7433 T8923 T8922 arg1Of motifs,CpG
R7434 T8927 T8924 arg2Of end,at
R7435 T8927 T8925 arg1Of end,the
R7436 T8927 T8926 arg1Of end,3′
R7437 T8930 T8928 arg2Of 1,(
R7438 T8930 T8929 arg1Of 1,#
R7439 T8930 T8931 arg1Of 1,","
R7440 T8932 T8931 arg2Of 2,","
R7441 T8933 T8928 arg3Of ),(
R7442 T8934 T8903 arg1Of showed,Furthermore
R7443 T8934 T8904 arg1Of showed,","
R7444 T8937 T8934 arg2Of correlation,showed
R7445 T8937 T8935 arg1Of correlation,this
R7446 T8937 T8936 arg1Of correlation,direct
R7447 T8937 T8938 arg1Of correlation,between
R7448 T8941 T8939 arg1Of status,high
R7449 T8941 T8940 arg1Of status,methylation
R7450 T8941 T8942 arg1Of status,and
R7451 T8942 T8938 arg2Of and,between
R7452 T8943 T8942 arg2Of absence,and
R7453 T8943 T8944 arg1Of absence,of
R7454 T8946 T8944 arg2Of expression,of
R7455 T8946 T8945 arg1Of expression,IRF-4
R7456 T8948 T8947 arg2Of addition,In
R7457 T8952 T8950 arg1Of sites,two
R7458 T8952 T8951 arg1Of sites,CpG
R7459 T8952 T8953 arg1Of sites,located
R7460 T8952 T8969 arg1Of sites,are
R7461 T8952 T8971 arg1Of sites,methylated
R7462 T8953 T8954 arg1Of located,in
R7463 T8956 T8955 arg1Of NFκB,a
R7464 T8956 T8957 arg1Of NFκB,(
R7465 T8956 T8961 arg1Of NFκB,and
R7466 T8959 T8957 arg2Of 48,(
R7467 T8959 T8958 arg1Of 48,#
R7468 T8960 T8957 arg3Of ),(
R7469 T8961 T8954 arg2Of and,in
R7470 T8964 T8961 arg2Of element,and
R7471 T8964 T8962 arg1Of element,a
R7472 T8964 T8963 arg1Of element,SP1
R7473 T8964 T8965 arg1Of element,(
R7474 T8967 T8965 arg2Of 45,(
R7475 T8967 T8966 arg1Of 45,#
R7476 T8968 T8965 arg3Of ),(
R7477 T8969 T8947 arg1Of are,In
R7478 T8969 T8949 arg1Of are,","
R7479 T8971 T8969 arg2Of methylated,are
R7480 T8971 T8970 arg1Of methylated,less
R7481 T8971 T8972 arg1Of methylated,in
R7482 T8971 T8974 arg1Of methylated,than
R7483 T8973 T8972 arg2Of IRF-4-positive,in
R7484 T8975 T8974 arg2Of in,than
R7485 T8980 T8975 arg2Of number,in
R7486 T8980 T8976 arg1Of number,IRF-4-negative
R7487 T8980 T8977 arg1Of number,cells
R7488 T8980 T8978 arg1Of number,(
R7489 T8980 T8979 arg1Of number,mean
R7490 T8980 T8981 arg1Of number,of
R7491 T8983 T8981 arg2Of clones,of
R7492 T8983 T8982 arg2Of clones,methylated
R7493 T8983 T8984 arg1Of clones,:
R7494 T8985 T8986 arg1Of 1/8,versus
R7495 T8986 T8988 arg1Of versus,)
R7496 T8987 T8986 arg2Of 8/8,versus
R7497 T8990 T8989 arg1Of results,These
R7498 T8990 T8991 arg1Of results,indicate
R7499 T8993 T8991 arg2Of involvement,indicate
R7500 T8993 T8992 arg1Of involvement,the
R7501 T8993 T8994 arg1Of involvement,of
R7502 T8993 T8997 arg1Of involvement,in
R7503 T8996 T8994 arg2Of methylation,of
R7504 T8996 T8995 arg1Of methylation,CpG
R7505 T8999 T8997 arg2Of regulation,in
R7506 T8999 T8998 arg1Of regulation,the
R7507 T8999 T9000 arg1Of regulation,of
R7508 T9002 T9000 arg2Of expression,of
R7509 T9002 T9001 arg1Of expression,IRF-4
R7510 T9002 T9003 arg1Of expression,in
R7511 T9005 T9003 arg2Of cells,in
R7512 T9005 T9004 arg1Of cells,leukemic
R772 T1106 T1104 arg1Of leukemia,Chronic
R773 T1106 T1105 arg1Of leukemia,myeloid
R774 T1106 T1107 arg1Of leukemia,(
R775 T1106 T1110 arg1Of leukemia,is
R776 T1108 T1107 arg2Of CML,(
R777 T1109 T1107 arg3Of ),(
R778 T1114 T1110 arg2Of disorder,is
R779 T1114 T1111 arg1Of disorder,a
R780 T1114 T1112 arg1Of disorder,clonal
R781 T1114 T1113 arg1Of disorder,myeloproliferative
R782 T1114 T1115 arg1Of disorder,with
R783 T1120 T1115 arg2Of course,with
R784 T1120 T1116 arg1Of course,a
R785 T1120 T1117 arg1Of course,typical
R786 T1120 T1118 arg1Of course,three
R787 T1120 T1119 arg1Of course,phased
R788 T1120 T1121 arg1Of course,(
R789 T1120 T1129 arg1Of course,reflecting
R790 T1122 T1123 arg1Of chronic,","
R791 T1123 T1125 arg1Of ",",and
R792 T1124 T1123 arg2Of accelerated,","
R793 T1126 T1125 arg2Of blastic,and
R794 T1127 T1121 arg2Of phase,(
R795 T1127 T1122 arg1Of phase,chronic
R796 T1127 T1124 arg1Of phase,accelerated
R797 T1127 T1126 arg1Of phase,blastic
R798 T1128 T1121 arg3Of ),(
R799 T1131 T1129 arg2Of loss,reflecting
R800 T1131 T1130 arg1Of loss,the
R801 T1131 T1132 arg1Of loss,of
R802 T1131 T1137 arg1Of loss,which
R803 T1131 T1139 arg1Of loss,leads
R804 T1133 T1134 arg1Of differentiation,and
R8042 T9707 T9706 arg1Of vitro,In
R8043 T9708 T9707 arg1Of methylation,vitro
R8044 T9708 T9709 arg1Of methylation,of
R8045 T9708 T9714 arg1Of methylation,decreases
R8046 T9713 T9709 arg2Of construct,of
R8047 T9713 T9710 arg1Of construct,an
R8048 T9713 T9711 arg1Of construct,IRF-4
R8049 T9713 T9712 arg1Of construct,promoter-reporter
R805 T1134 T1132 arg2Of and,of
R8050 T9716 T9714 arg2Of activity,decreases
R8051 T9716 T9715 arg1Of activity,its
R8052 T9718 T9717 arg1Of provide,To
R8053 T9719 T9718 arg2Of evidence,provide
R8054 T9719 T9720 arg1Of evidence,for
R8055 T9723 T9720 arg2Of effect,for
R8056 T9723 T9721 arg1Of effect,a
R8057 T9723 T9722 arg1Of effect,direct
R8058 T9723 T9724 arg1Of effect,of
R8059 T9723 T9727 arg1Of effect,on
R806 T1136 T1134 arg2Of progress,and
R8060 T9726 T9724 arg2Of status,of
R8061 T9726 T9725 arg1Of status,methylational
R8062 T9730 T9727 arg2Of activity,on
R8063 T9730 T9728 arg1Of activity,IRF-4
R8064 T9730 T9729 arg1Of activity,promoter
R8065 T9731 T9718 arg1Of we,provide
R8066 T9731 T9732 arg1Of we,performed
R8067 T9732 T9717 modOf performed,To
R8068 T9732 T9740 arg1Of performed,before
R8069 T9732 T9742 arg1Of performed,after
R807 T1136 T1135 arg1Of progress,malignant
R8070 T9735 T9732 arg2Of assays,performed
R8071 T9735 T9733 arg1Of assays,reporter
R8072 T9735 T9734 arg1Of assays,gene
R8073 T9735 T9736 arg1Of assays,with
R8074 T9739 T9736 arg2Of constructs,with
R8075 T9739 T9737 arg1Of constructs,IRF-4
R8076 T9739 T9738 arg1Of constructs,promoter
R8077 T9740 T9741 arg1Of before,and
R8078 T9742 T9741 arg2Of after,and
R8079 T9745 T9744 arg1Of vitro,in
R808 T1139 T1138 arg1Of leads,inevitably
R8080 T9746 T9740 arg2Of methylation,before
R8081 T9746 T9742 arg2Of methylation,after
R8082 T9746 T9743 arg1Of methylation,their
R8083 T9746 T9745 arg1Of methylation,vitro
R8084 T9749 T9747 arg1Of methylation,A
R8085 T9749 T9748 arg1Of methylation,complete
R8086 T9749 T9750 arg1Of methylation,of
R8087 T9749 T9753 arg1Of methylation,was
R8088 T9749 T9754 arg2Of methylation,checked
R8089 T9752 T9750 arg2Of constructs,of
R809 T1139 T1140 arg1Of leads,to
R8090 T9752 T9751 arg1Of constructs,these
R8091 T9754 T9753 arg2Of checked,was
R8092 T9754 T9755 arg1Of checked,via
R8093 T9757 T9755 arg2Of assays,via
R8094 T9757 T9756 arg1Of assays,restriction
R8095 T9757 T9758 arg1Of assays,with
R8096 T9760 T9758 arg2Of endonucleases,with
R8097 T9760 T9759 arg1Of endonucleases,methylation-sensitive
R8098 T9760 T9761 arg1Of endonucleases,(
R8099 T9763 T9761 arg2Of 5A,(
R810 T1139 T1142 arg1Of leads,after
R8100 T9763 T9762 arg1Of 5A,Figure
R8101 T9764 T9761 arg3Of ),(
R8102 T9767 T9768 arg1Of methylation,of
R8103 T9767 T9773 arg1Of methylation,decreased
R8104 T9771 T9768 arg2Of promoter,of
R8105 T9771 T9769 arg1Of promoter,the
R8106 T9771 T9770 arg1Of promoter,IRF-4
R8107 T9773 T9765 arg1Of decreased,Intriguingly
R8108 T9773 T9766 arg1Of decreased,","
R8109 T9773 T9772 arg1Of decreased,significantly
R811 T1141 T1140 arg2Of death,to
R8110 T9773 T9780 arg1Of decreased,by
R8111 T9775 T9773 arg2Of activity,decreased
R8112 T9775 T9774 arg1Of activity,promoter
R8113 T9775 T9776 arg1Of activity,in
R8114 T9779 T9776 arg2Of cells,in
R8115 T9779 T9777 arg1Of cells,IRF-4-positive
R8116 T9779 T9778 arg1Of cells,SD-1
R8117 T9782 T9780 arg2Of %,by
R8118 T9782 T9781 arg1Of %,85.0
R8119 T9782 T9783 arg1Of %,(
R812 T1145 T1142 arg2Of phase,after
R8120 T9785 T9783 arg2Of 5B,(
R8121 T9785 T9784 arg1Of 5B,Figure
R8122 T9786 T9783 arg3Of ),(
R8123 T9789 T9787 arg1Of effect,The
R8124 T9789 T9788 arg1Of effect,silencing
R8125 T9789 T9790 arg1Of effect,of
R8126 T9789 T9793 arg1Of effect,was
R8127 T9789 T9795 arg1Of effect,restricted
R8128 T9792 T9790 arg2Of methylation,of
R8129 T9792 T9791 arg1Of methylation,CpG
R813 T1145 T1143 arg1Of phase,the
R8130 T9793 T9794 arg1Of was,not
R8131 T9793 T9799 arg1Of was,","
R8132 T9793 T9800 arg1Of was,since
R8133 T9795 T9793 arg2Of restricted,was
R8134 T9795 T9796 arg1Of restricted,to
R8135 T9798 T9796 arg2Of cells,to
R8136 T9798 T9797 arg1Of cells,IRF-4-positive
R8137 T9802 T9801 arg1Of vitro,in
R8138 T9803 T9802 arg1Of methylation,vitro
R8139 T9803 T9804 arg1Of methylation,led
R814 T1145 T1144 arg1Of phase,blastic
R8140 T9804 T9800 arg2Of led,since
R8141 T9804 T9805 arg1Of led,to
R8142 T9807 T9808 arg1Of 92.9,%
R8143 T9809 T9805 arg2Of abrogation,to
R8144 T9809 T9806 arg1Of abrogation,a
R8145 T9809 T9807 arg1Of abrogation,92.9
R8146 T9809 T9810 arg1Of abrogation,of
R8147 T9809 T9813 arg1Of abrogation,in
R8148 T9812 T9810 arg2Of activity,of
R8149 T9812 T9811 arg1Of activity,promoter
R815 T1145 T1146 arg1Of phase,(
R8150 T9816 T9813 arg2Of cells,in
R8151 T9816 T9814 arg1Of cells,IRF-4-negative
R8152 T9816 T9815 arg1Of cells,Jurkat
R8153 T9816 T9817 arg1Of cells,(
R8154 T9819 T9817 arg2Of 5C,(
R8155 T9819 T9818 arg1Of 5C,Figure
R8156 T9820 T9817 arg3Of ),(
R8157 T9822 T9821 arg2Of contrast,In
R8158 T9825 T9824 arg1Of methylation,control
R8159 T9825 T9826 arg1Of methylation,of
R816 T1147 T1146 arg2Of "1,2",(
R8160 T9825 T9830 arg1Of methylation,with
R8161 T9825 T9843 arg1Of methylation,had
R8162 T9829 T9826 arg2Of construct,of
R8163 T9829 T9827 arg1Of construct,a
R8164 T9829 T9828 arg1Of construct,reporter
R8165 T9833 T9831 arg1Of promoter,a
R8166 T9833 T9832 arg1Of promoter,different
R8167 T9833 T9834 arg1Of promoter,(
R8168 T9833 T9839 arg1Of promoter,as
R8169 T9835 T9834 arg2Of FasL,(
R817 T1148 T1146 arg3Of ),(
R8170 T9836 T9834 arg3Of ),(
R8171 T9839 T9830 arg2Of as,with
R8172 T9839 T9837 arg1Of as,as
R8173 T9839 T9838 arg1Of as,well
R8174 T9842 T9839 arg2Of vector,as
R8175 T9842 T9840 arg1Of vector,an
R8176 T9842 T9841 arg1Of vector,empty
R8177 T9843 T9821 arg1Of had,In
R8178 T9843 T9823 arg1Of had,","
R8179 T9845 T9843 arg2Of effect,had
R818 T1152 T1149 arg1Of aberration,The
R8180 T9845 T9844 arg1Of effect,no
R8181 T9845 T9846 arg1Of effect,on
R8182 T9849 T9846 arg2Of activity,on
R8183 T9849 T9847 arg1Of activity,the
R8184 T9849 T9848 arg1Of activity,reporter
R8185 T9849 T9850 arg1Of activity,(
R8186 T9851 T9850 arg2Of data,(
R8187 T9851 T9853 arg2Of data,shown
R8188 T9853 T9852 arg1Of shown,not
R8189 T9854 T9850 arg3Of ),(
R819 T1152 T1150 arg1Of aberration,hallmark
R8190 T9856 T9855 arg1Of data,These
R8191 T9856 T9857 arg1Of data,proved
R8192 T9860 T9857 arg2Of association,proved
R8193 T9860 T9858 arg1Of association,a
R8194 T9860 T9859 arg1Of association,direct
R8195 T9860 T9861 arg1Of association,between
R8196 T9862 T9863 arg1Of methylation,and
R8197 T9863 T9861 arg2Of and,between
R8198 T9863 T9865 arg1Of and,of
R8199 T9864 T9863 arg2Of activity,and
R820 T1152 T1151 arg1Of aberration,genetic
R8200 T9868 T9865 arg2Of promoter,of
R8201 T9868 T9866 arg1Of promoter,the
R8202 T9868 T9867 arg1Of promoter,IRF-4
R821 T1152 T1153 arg1Of aberration,of
R822 T1152 T1155 arg1Of aberration,is
R823 T1154 T1153 arg2Of CML,of
R824 T1160 T1155 arg2Of t,is
R825 T1160 T1156 arg1Of t,a
R826 T1160 T1157 arg1Of t,reciprocal
R827 T1160 T1158 arg1Of t,chromosomal
R828 T1160 T1159 arg1Of t,translocation
R829 T1160 T1161 arg1Of t,(
R830 T1160 T1166 arg1Of t,leading
R831 T1162 T1163 arg1Of 9,;
R832 T1163 T1161 arg2Of ;,(
R833 T1164 T1163 arg2Of 22,;
R834 T1165 T1161 arg3Of ),(
R835 T1166 T1167 arg1Of leading,to
R836 T1168 T1167 arg2Of expression,to
R837 T1168 T1169 arg1Of expression,of
R838 T1173 T1169 arg2Of gene,of
R839 T1173 T1170 arg1Of gene,a
R840 T1173 T1171 arg1Of gene,bcr-abl
R841 T1173 T1172 arg1Of gene,fusion
R842 T1173 T1174 arg1Of gene,","
R843 T1179 T1174 arg2Of kinase,","
R844 T1179 T1175 arg1Of kinase,an
R845 T1179 T1176 arg1Of kinase,aberrant
R846 T1179 T1177 arg2Of kinase,activated
R847 T1179 T1178 arg1Of kinase,tyrosine
R848 T1179 T1180 arg1Of kinase,(
R8480 T10257 T10256 arg1Of expression,mRNA
R8481 T10257 T10258 arg1Of expression,of
R8482 T10257 T10264 arg1Of expression,may
R8483 T10257 T10266 arg1Of expression,be
R8484 T10257 T10267 arg2Of expression,associated
R8485 T10260 T10259 arg1Of methyltransferases,DNA
R8486 T10260 T10261 arg1Of methyltransferases,and
R8487 T10261 T10258 arg2Of and,of
R8488 T10263 T10261 arg2Of proteins,and
R8489 T10263 T10262 arg1Of proteins,methyl-CpG-binding
R849 T1181 T1180 arg2Of 2,(
R8490 T10267 T10264 arg2Of associated,may
R8491 T10267 T10265 arg1Of associated,not
R8492 T10267 T10266 arg2Of associated,be
R8493 T10267 T10268 arg1Of associated,with
R8494 T10271 T10268 arg2Of methylation,with
R8495 T10271 T10269 arg1Of methylation,IRF-4
R8496 T10271 T10270 arg1Of methylation,promoter
R8497 T10273 T10274 arg1Of abundance,of
R8498 T10273 T10278 arg1Of abundance,contribute
R8499 T10275 T10276 arg1Of DNMT,and
R850 T1182 T1180 arg3Of ),(
R8500 T10276 T10274 arg2Of and,of
R8501 T10277 T10276 arg2Of MBP,and
R8502 T10278 T10272 arg2Of contribute,Since
R8503 T10278 T10279 arg1Of contribute,to
R8504 T10278 T10282 arg1Of contribute,via
R8505 T10281 T10279 arg2Of regulation,to
R8506 T10281 T10280 arg1Of regulation,promoter
R8507 T10283 T10282 arg2Of methylation,via
R8508 T10283 T10284 arg1Of methylation,(
R8509 T10285 T10284 arg2Of "25,26,28",(
R851 T1183 T1184 arg1Of Treatment,with
R8510 T10286 T10284 arg3Of ),(
R8511 T10288 T10289 arg1Of we,studied
R8512 T10288 T10294 arg1Of we,investigate
R8513 T10289 T10272 arg1Of studied,Since
R8514 T10289 T10287 arg1Of studied,","
R8515 T10289 T10293 modOf studied,to
R8516 T10292 T10289 arg2Of expression,studied
R8517 T10292 T10290 arg1Of expression,their
R8518 T10292 T10291 arg1Of expression,mRNA
R8519 T10294 T10293 arg1Of investigate,to
R852 T1183 T1190 arg1Of Treatment,prolongs
R8520 T10297 T10294 arg2Of mechanism,investigate
R8521 T10297 T10295 arg1Of mechanism,a
R8522 T10297 T10296 arg1Of mechanism,possible
R8523 T10297 T10298 arg1Of mechanism,for
R8524 T10302 T10298 arg2Of differences,for
R8525 T10302 T10299 arg1Of differences,the
R8526 T10302 T10300 arg2Of differences,observed
R8527 T10302 T10301 arg1Of differences,methylation
R8528 T10302 T10303 arg1Of differences,in
R8529 T10306 T10303 arg2Of promoter,in
R853 T1183 T1196 arg1Of Treatment,is
R8530 T10306 T10304 arg1Of promoter,the
R8531 T10306 T10305 arg1Of promoter,IRF-4
R8532 T10309 T10307 arg2Of end,To
R8533 T10309 T10308 arg1Of end,this
R8534 T10311 T10312 arg1Of we,did
R8535 T10311 T10314 arg1Of we,detect
R8536 T10314 T10307 arg1Of detect,To
R8537 T10314 T10310 arg1Of detect,","
R8538 T10314 T10312 arg2Of detect,did
R8539 T10314 T10313 arg1Of detect,not
R854 T1183 T1197 arg2Of Treatment,associated
R8540 T10317 T10316 arg1Of difference,significant
R8541 T10317 T10318 arg1Of difference,in
R8542 T10317 T10320 arg1Of difference,(
R8543 T10317 T10327 arg1Of difference,or
R8544 T10319 T10318 arg2Of DNMT,in
R8545 T10321 T10322 arg1Of DNMT1,","
R8546 T10322 T10324 arg1Of ",",and
R8547 T10323 T10322 arg2Of DNMT3A,","
R8548 T10324 T10320 arg2Of and,(
R8549 T10325 T10324 arg2Of DNMT3B,and
R855 T1186 T1184 arg2Of α,with
R8550 T10326 T10320 arg3Of ),(
R8551 T10327 T10314 arg2Of or,detect
R8552 T10327 T10315 arg1Of or,a
R8553 T10328 T10329 arg1Of MBP,(
R8554 T10330 T10331 arg1Of MBD1,","
R8555 T10331 T10333 arg1Of ",",","
R8556 T10332 T10331 arg2Of MBD2,","
R8557 T10333 T10335 arg1Of ",",and
R8558 T10334 T10333 arg2Of MBD4,","
R8559 T10335 T10329 arg2Of and,(
R856 T1186 T1185 arg1Of α,interferon
R8560 T10336 T10335 arg2Of MeCP,and
R8561 T10337 T10329 arg3Of ),(
R8562 T10339 T10327 arg2Of expression,or
R8563 T10339 T10328 arg1Of expression,MBP
R8564 T10339 T10338 arg1Of expression,mRNA
R8565 T10339 T10340 arg1Of expression,between
R8566 T10341 T10342 arg1Of IRF-4-positive,and
R8567 T10343 T10342 arg2Of -negative,and
R8568 T10344 T10340 arg2Of cells,between
R8569 T10344 T10341 arg1Of cells,IRF-4-positive
R857 T1186 T1187 arg1Of α,(
R8570 T10344 T10343 arg1Of cells,-negative
R8571 T10344 T10345 arg1Of cells,(
R8572 T10347 T10345 arg2Of 5D,(
R8573 T10347 T10346 arg1Of 5D,Figure
R8574 T10348 T10345 arg3Of ),(
R8575 T10350 T10349 arg2Of fact,In
R8576 T10354 T10352 arg1Of cells,all
R8577 T10354 T10353 arg2Of cells,analyzed
R8578 T10354 T10355 arg1Of cells,had
R8579 T10355 T10349 arg1Of had,In
R858 T1188 T1187 arg2Of IFN-α,(
R8580 T10355 T10351 arg1Of had,","
R8581 T10355 T10365 arg1Of had,and
R8582 T10358 T10356 arg1Of high,moderate
R8583 T10358 T10357 arg1Of high,to
R8584 T10360 T10355 arg2Of levels,had
R8585 T10360 T10358 arg1Of levels,high
R8586 T10360 T10359 arg1Of levels,mRNA
R8587 T10360 T10361 arg1Of levels,of
R8588 T10364 T10361 arg2Of DNMT/MBPs,of
R8589 T10364 T10362 arg1Of DNMT/MBPs,these
R859 T1189 T1187 arg3Of ),(
R8590 T10364 T10363 arg2Of DNMT/MBPs,tested
R8591 T10366 T10367 arg1Of differences,in
R8592 T10366 T10369 arg1Of differences,were
R8593 T10366 T10371 arg2Of differences,correlated
R8594 T10368 T10367 arg2Of expression,in
R8595 T10371 T10365 arg2Of correlated,and
R8596 T10371 T10369 arg2Of correlated,were
R8597 T10371 T10370 arg1Of correlated,not
R8598 T10371 T10372 arg1Of correlated,with
R8599 T10374 T10372 arg2Of status,with
R860 T1190 T1195 arg1Of prolongs,and
R8600 T10374 T10373 arg1Of status,IRF-4
R8601 T10376 T10375 arg1Of results,These
R8602 T10376 T10377 arg1Of results,indicate
R8603 T10380 T10377 arg2Of cause,indicate
R8604 T10380 T10378 arg1Of cause,a
R8605 T10380 T10379 arg1Of cause,distinct
R8606 T10380 T10381 arg1Of cause,of
R8607 T10380 T10390 arg1Of cause,rather
R8608 T10384 T10381 arg2Of differences,of
R8609 T10384 T10382 arg1Of differences,the
R861 T1191 T1190 arg2Of survival,prolongs
R8610 T10384 T10383 arg1Of differences,methylation
R8611 T10384 T10385 arg1Of differences,in
R8612 T10386 T10387 arg1Of IRF-4-positive,and
R8613 T10388 T10387 arg2Of -negative,and
R8614 T10389 T10385 arg2Of cells,in
R8615 T10389 T10386 arg1Of cells,IRF-4-positive
R8616 T10389 T10388 arg1Of cells,-negative
R8617 T10390 T10391 arg1Of rather,than
R8618 T10392 T10391 arg2Of changes,than
R8619 T10392 T10393 arg1Of changes,in
R862 T1191 T1192 arg1Of survival,of
R8620 T10395 T10396 arg1Of DNMT,and
R8621 T10397 T10396 arg2Of MBP,and
R8622 T10399 T10393 arg2Of transcription,in
R8623 T10399 T10394 arg1Of transcription,the
R8624 T10399 T10395 arg1Of transcription,DNMT
R8625 T10399 T10397 arg1Of transcription,MBP
R8626 T10399 T10398 arg1Of transcription,mRNA
R863 T1194 T1192 arg2Of patients,of
R864 T1194 T1193 arg1Of patients,CML
R865 T1197 T1195 arg2Of associated,and
R866 T1197 T1196 arg2Of associated,is
R867 T1197 T1198 arg1Of associated,with
R868 T1202 T1198 arg2Of response,with
R869 T1202 T1199 arg1Of response,a
R870 T1202 T1200 arg1Of response,complete
R871 T1202 T1201 arg1Of response,cytogenetic
R872 T1202 T1203 arg1Of response,in
R873 T1205 T1203 arg2Of %,in
R874 T1205 T1204 arg1Of %,5–33
R875 T1205 T1206 arg1Of %,of
R876 T1208 T1206 arg2Of patients,of
R877 T1208 T1207 arg1Of patients,CML
R878 T1208 T1209 arg1Of patients,(
R879 T1210 T1209 arg2Of "1,2",(
R880 T1211 T1209 arg3Of ),(
R881 T1214 T1215 arg1Of we,described
R882 T1215 T1212 arg1Of described,Recently
R883 T1215 T1213 arg1Of described,","
R884 T1215 T1228 arg1Of described,in
R885 T1215 T1230 arg1Of described,","
R886 T1215 T1231 modOf described,correlating
R887 T1218 T1215 arg2Of expression,described
R888 T1218 T1216 arg1Of expression,an
R889 T1218 T1217 arg1Of expression,impaired
R890 T1218 T1219 arg1Of expression,of
R891 T1223 T1219 arg2Of factor,of
R892 T1223 T1220 arg1Of factor,the
R893 T1223 T1221 arg1Of factor,interferon
R894 T1223 T1222 arg1Of factor,regulatory
R895 T1223 T1224 arg1Of factor,4
R896 T1223 T1225 arg1Of factor,(
R897 T1226 T1225 arg2Of IRF-4,(
R898 T1227 T1225 arg3Of ),(
R899 T1229 T1228 arg2Of CML,in
R900 T1231 T1232 arg1Of correlating,with
R901 T1234 T1232 arg2Of response,with
R902 T1234 T1233 arg1Of response,poor
R903 T1234 T1235 arg1Of response,to
R904 T1237 T1235 arg2Of treatment,to
R905 T1237 T1236 arg1Of treatment,IFN-α
R906 T1237 T1238 arg1Of treatment,(
R907 T1239 T1238 arg2Of 3,(
R908 T1240 T1238 arg3Of ),(
R909 T1242 T1241 arg1Of cause,The
R910 T1242 T1243 arg1Of cause,of
R911 T1242 T1249 arg1Of cause,remained
R912 T1242 T1250 arg1Of cause,unclear
R913 T1245 T1243 arg2Of silencing,of
R914 T1245 T1244 arg1Of silencing,the
R915 T1245 T1246 arg1Of silencing,of
R916 T1248 T1246 arg2Of level,of
R917 T1248 T1247 arg1Of level,IRF-4
R918 T1250 T1249 arg2Of unclear,remained
R919 T1253 T1251 arg1Of factors,Interferon
R920 T1253 T1252 arg1Of factors,regulatory
R921 T1253 T1254 arg1Of factors,(
R922 T1253 T1257 arg1Of factors,are
R9224 T11348 T11346 arg1Of lesions,Many
R9225 T11348 T11347 arg1Of lesions,genetic
R9226 T11348 T11349 arg1Of lesions,are
R9227 T11348 T11350 arg2Of lesions,known
R9228 T11348 T11352 arg1Of lesions,influence
R9229 T11350 T11349 arg2Of known,are
R923 T1255 T1254 arg2Of IRFs,(
R9230 T11352 T11350 arg3Of influence,known
R9231 T11352 T11351 arg1Of influence,to
R9232 T11354 T11352 arg2Of expression,influence
R9233 T11354 T11353 arg1Of expression,gene
R9234 T11354 T11355 arg1Of expression,of
R9235 T11358 T11355 arg2Of genes,of
R9236 T11358 T11356 arg1Of genes,tumor
R9237 T11358 T11357 arg1Of genes,suppressor
R9238 T11360 T11361 arg1Of mutations,and
R9239 T11361 T11365 arg1Of and,have
R924 T1256 T1254 arg3Of ),(
R9240 T11362 T11363 arg1Of deletions,or
R9241 T11363 T11361 arg2Of or,and
R9242 T11364 T11363 arg2Of insertions,or
R9243 T11365 T11359 arg2Of have,Whereas
R9244 T11367 T11365 arg2Of effects,have
R9245 T11367 T11366 arg1Of effects,permanent
R9246 T11370 T11369 arg1Of mechanisms,reversible
R9247 T11370 T11371 arg1Of mechanisms,are
R9248 T11371 T11359 arg1Of are,Whereas
R9249 T11371 T11368 arg1Of are,","
R925 T1259 T1257 arg2Of family,are
R9250 T11371 T11382 arg1Of are,","
R9251 T11371 T11383 arg1Of are,respectively
R9252 T11373 T11372 arg1Of methylation,gene
R9253 T11373 T11375 arg1Of methylation,or
R9254 T11375 T11371 arg2Of or,are
R9255 T11375 T11374 arg1Of or,","
R9256 T11375 T11379 arg1Of or,of
R9257 T11376 T11377 arg1Of expression,and
R9258 T11377 T11375 arg2Of and,or
R9259 T11378 T11377 arg2Of activation,and
R926 T1259 T1258 arg1Of family,a
R9260 T11381 T11379 arg2Of factors,of
R9261 T11381 T11380 arg1Of factors,transcription
R9262 T11384 T11385 arg1Of We,studied
R9263 T11384 T11398 arg1Of We,focused
R9264 T11385 T11396 arg1Of studied,and
R9265 T11388 T11385 arg2Of cause,studied
R9266 T11388 T11386 arg1Of cause,a
R9267 T11388 T11387 arg1Of cause,putative
R9268 T11388 T11389 arg1Of cause,for
R9269 T11392 T11389 arg2Of expression,for
R927 T1259 T1260 arg1Of family,of
R9270 T11392 T11390 arg1Of expression,absent
R9271 T11392 T11391 arg1Of expression,IRF-4
R9272 T11392 T11393 arg1Of expression,in
R9273 T11395 T11393 arg2Of cells,in
R9274 T11395 T11394 arg1Of cells,leukemia
R9275 T11398 T11396 arg2Of focused,and
R9276 T11398 T11397 arg1Of focused,first
R9277 T11398 T11399 arg1Of focused,on
R9278 T11401 T11399 arg2Of aberrations,on
R9279 T11401 T11400 arg1Of aberrations,genetic
R928 T1262 T1260 arg2Of regulators,of
R9280 T11401 T11402 arg1Of aberrations,of
R9281 T11404 T11402 arg2Of promoter,of
R9282 T11404 T11403 arg1Of promoter,the
R9283 T11405 T11406 arg1Of We,observed
R9284 T11406 T11424 arg1Of observed,:
R9285 T11409 T11406 arg2Of alterations,observed
R9286 T11409 T11407 arg1Of alterations,no
R9287 T11409 T11408 arg1Of alterations,genetic
R9288 T11409 T11410 arg1Of alterations,in
R9289 T11413 T11410 arg2Of promoter,in
R929 T1262 T1261 arg1Of regulators,transcriptional
R9290 T11413 T11411 arg1Of promoter,the
R9291 T11413 T11412 arg1Of promoter,IRF-4
R9292 T11413 T11414 arg1Of promoter,","
R9293 T11413 T11415 arg1Of promoter,which
R9294 T11413 T11416 arg1Of promoter,can
R9295 T11413 T11417 arg1Of promoter,account
R9296 T11417 T11416 arg2Of account,can
R9297 T11417 T11418 arg1Of account,for
R9298 T11420 T11418 arg2Of lack,for
R9299 T11420 T11419 arg1Of lack,the
R930 T1262 T1263 arg2Of regulators,defined
R9300 T11420 T11421 arg1Of lack,of
R9301 T11423 T11421 arg2Of expression,of
R9302 T11423 T11422 arg1Of expression,IRF-4
R9303 T11429 T11425 arg1Of changes,The
R9304 T11429 T11426 arg2Of changes,detected
R9305 T11429 T11427 arg1Of changes,base
R9306 T11429 T11428 arg1Of changes,pair
R9307 T11429 T11430 arg1Of changes,at
R9308 T11429 T11437 arg1Of changes,","
R9309 T11429 T11438 arg1Of changes,at
R931 T1267 T1263 arg1Of homology,defined
R9310 T11429 T11446 arg1Of changes,at
R9311 T11429 T11453 arg1Of changes,are
R9312 T11432 T11430 arg2Of −1081,at
R9313 T11432 T11431 arg1Of −1081,position
R9314 T11432 T11433 arg1Of −1081,(
R9315 T11435 T11433 arg2Of substitution,(
R9316 T11435 T11434 arg1Of substitution,T→C
R9317 T11436 T11433 arg3Of ),(
R9318 T11438 T11445 arg1Of at,and
R9319 T11439 T11438 arg2Of position,at
R932 T1267 T1264 arg2Of homology,by
R9320 T11439 T11440 arg1Of position,−1068
R9321 T11439 T11441 arg1Of position,(
R9322 T11443 T11441 arg2Of substitution,(
R9323 T11443 T11442 arg1Of substitution,A→C
R9324 T11444 T11441 arg3Of ),(
R9325 T11446 T11445 arg2Of at,and
R9326 T11447 T11446 arg2Of position,at
R9327 T11447 T11448 arg1Of position,−116
R9328 T11447 T11449 arg1Of position,(
R9329 T11451 T11449 arg2Of substitution,(
R933 T1267 T1265 arg1Of homology,a
R9330 T11451 T11450 arg1Of substitution,A→C
R9331 T11452 T11449 arg3Of ),(
R9332 T11453 T11472 arg1Of are,whereas
R9333 T11455 T11456 arg1Of responsible,for
R9334 T11455 T11469 arg1Of responsible,and
R9335 T11458 T11456 arg2Of IRF-4-expression,for
R9336 T11458 T11457 arg1Of IRF-4-expression,absent
R9337 T11458 T11459 arg1Of IRF-4-expression,since
R9338 T11463 T11460 arg1Of mutations,the
R9339 T11463 T11461 arg1Of mutations,first
R934 T1267 T1266 arg1Of homology,characteristic
R9340 T11463 T11462 arg1Of mutations,two
R9341 T11463 T11464 arg1Of mutations,were
R9342 T11463 T11465 arg2Of mutations,found
R9343 T11465 T11459 arg2Of found,since
R9344 T11465 T11464 arg2Of found,were
R9345 T11465 T11467 arg1Of found,in
R9346 T11467 T11466 arg1Of in,both
R9347 T11468 T11467 arg2Of IRF-4-positive,in
R9348 T11470 T11469 arg2Of -negative,and
R9349 T11471 T11453 arg2Of cells,are
R935 T1267 T1268 arg1Of homology,in
R9350 T11471 T11454 arg1Of cells,unlikely
R9351 T11471 T11455 arg1Of cells,responsible
R9352 T11471 T11470 arg1Of cells,-negative
R9353 T11475 T11473 arg1Of change,the
R9354 T11475 T11474 arg1Of change,latter
R9355 T11475 T11476 arg1Of change,was
R9356 T11475 T11478 arg2Of change,detected
R9357 T11475 T11487 arg1Of change,may
R9358 T11475 T11489 arg1Of change,be
R9359 T11478 T11476 arg2Of detected,was
R936 T1271 T1268 arg2Of domain,in
R9360 T11478 T11477 arg1Of detected,not
R9361 T11478 T11479 arg1Of detected,consistently
R9362 T11478 T11480 arg1Of detected,in
R9363 T11478 T11486 arg1Of detected,and
R9364 T11482 T11483 arg1Of IRF-4-negative,or
R9365 T11484 T11483 arg2Of -positive,or
R9366 T11485 T11480 arg2Of cells,in
R9367 T11485 T11481 arg1Of cells,all
R9368 T11485 T11482 arg1Of cells,IRF-4-negative
R9369 T11485 T11484 arg1Of cells,-positive
R937 T1271 T1269 arg1Of domain,their
R9370 T11486 T11472 arg2Of and,whereas
R9371 T11489 T11486 arg2Of be,and
R9372 T11489 T11487 arg2Of be,may
R9373 T11489 T11488 arg1Of be,thus
R9374 T11491 T11489 arg2Of polymorphism,be
R9375 T11491 T11490 arg1Of polymorphism,a
R9376 T11494 T11492 arg1Of substitutions,All
R9377 T11494 T11493 arg1Of substitutions,three
R9378 T11494 T11495 arg1Of substitutions,did
R9379 T11494 T11497 arg1Of substitutions,change
R938 T1271 T1270 arg1Of domain,DNA-binding
R9380 T11494 T11510 arg1Of substitutions,do
R9381 T11494 T11512 arg1Of substitutions,affect
R9382 T11497 T11495 arg2Of change,did
R9383 T11497 T11496 arg1Of change,not
R9384 T11497 T11508 arg1Of change,and
R9385 T11504 T11497 arg2Of sites,change
R9386 T11504 T11498 arg1Of sites,any
R9387 T11504 T11499 arg1Of sites,known
R9388 T11504 T11500 arg1Of sites,putative
R9389 T11504 T11501 arg1Of sites,transcription
R939 T1272 T1273 arg1Of They,play
R9390 T11504 T11502 arg1Of sites,factor
R9391 T11504 T11503 arg1Of sites,binding
R9392 T11504 T11505 arg1Of sites,(
R9393 T11506 T11505 arg2Of "30,31",(
R9394 T11507 T11505 arg3Of ),(
R9395 T11512 T11508 arg2Of affect,and
R9396 T11512 T11509 arg1Of affect,also
R9397 T11512 T11510 arg2Of affect,do
R9398 T11512 T11511 arg1Of affect,not
R9399 T11515 T11514 arg1Of sites,restriction
R940 T1273 T1277 arg1Of play,in
R9400 T11515 T11516 arg1Of sites,or
R9401 T11516 T11512 arg2Of or,affect
R9402 T11516 T11513 arg1Of or,any
R9403 T11516 T11520 arg1Of or,of
R9404 T11519 T11516 arg2Of sites,or
R9405 T11519 T11517 arg1Of sites,primer
R9406 T11519 T11518 arg1Of sites,binding
R9407 T11523 T11520 arg2Of assays,of
R9408 T11523 T11521 arg1Of assays,the
R9409 T11523 T11522 arg2Of assays,used
R941 T1276 T1273 arg2Of role,play
R9410 T11528 T11526 arg1Of variations,permanent
R9411 T11528 T11527 arg1Of variations,genetic
R9412 T11528 T11529 arg1Of variations,in
R9413 T11528 T11534 arg1Of variations,","
R9414 T11528 T11536 arg1Of variations,as
R9415 T11528 T11543 arg1Of variations,have
R9416 T11528 T11545 arg1Of variations,been
R9417 T11528 T11546 arg2Of variations,excluded
R9418 T11533 T11529 arg2Of sequence,in
R9419 T11533 T11530 arg1Of sequence,the
R942 T1276 T1274 arg1Of role,an
R9420 T11533 T11531 arg1Of sequence,IRF-4
R9421 T11533 T11532 arg1Of sequence,coding
R9422 T11536 T11535 arg1Of as,such
R9423 T11537 T11538 arg1Of deletions,or
R9424 T11538 T11536 arg2Of or,as
R9425 T11538 T11540 arg1Of or,resulting
R9426 T11539 T11538 arg2Of mutations,or
R9427 T11540 T11541 arg1Of resulting,in
R9428 T11542 T11541 arg2Of stop-codons,in
R9429 T11546 T11524 arg1Of excluded,However
R943 T1276 T1275 arg1Of role,important
R9430 T11546 T11525 arg1Of excluded,","
R9431 T11546 T11543 arg2Of excluded,have
R9432 T11546 T11544 arg1Of excluded,not
R9433 T11546 T11545 arg2Of excluded,been
R9434 T11549 T11546 arg1Of analysis,excluded
R9435 T11549 T11547 arg2Of analysis,by
R9436 T11549 T11548 arg1Of analysis,sequence
R9437 T11552 T11551 arg1Of expression,IRF-4
R9438 T11552 T11553 arg1Of expression,in
R9439 T11552 T11558 arg1Of expression,can
R944 T1279 T1280 arg1Of regulation,of
R9440 T11552 T11559 arg1Of expression,be
R9441 T11552 T11560 arg2Of expression,induced
R9442 T11555 T11554 arg1Of lines,cell
R9443 T11555 T11556 arg1Of lines,and
R9444 T11556 T11553 arg2Of and,in
R9445 T11557 T11556 arg2Of CML,and
R9446 T11560 T11550 arg2Of induced,Since
R9447 T11560 T11558 arg2Of induced,can
R9448 T11560 T11559 arg2Of induced,be
R9449 T11560 T11570 arg1Of induced,","
R945 T1279 T1294 arg1Of regulation,","
R9450 T11560 T11571 arg1Of induced,respectively
R9451 T11562 T11563 arg1Of demethylation,and
R9452 T11563 T11560 arg1Of and,induced
R9453 T11563 T11561 arg2Of and,by
R9454 T11566 T11563 arg2Of therapy,and
R9455 T11566 T11564 arg1Of therapy,successful
R9456 T11566 T11565 arg1Of therapy,IFN-α
R9457 T11566 T11567 arg1Of therapy,(
R9458 T11568 T11567 arg2Of 3,(
R9459 T11569 T11567 arg3Of ),(
R946 T1282 T1280 arg2Of genes,of
R9460 T11574 T11573 arg1Of existence,the
R9461 T11574 T11575 arg1Of existence,of
R9462 T11574 T11579 arg1Of existence,seems
R9463 T11574 T11580 arg1Of existence,unlikely
R9464 T11578 T11575 arg2Of aberrations,of
R9465 T11578 T11576 arg1Of aberrations,such
R9466 T11578 T11577 arg1Of aberrations,genetic
R9467 T11579 T11550 arg1Of seems,Since
R9468 T11579 T11572 arg1Of seems,","
R9469 T11580 T11579 arg2Of unlikely,seems
R947 T1282 T1281 arg1Of genes,various
R9470 T11581 T11583 arg1Of We,investigated
R9471 T11583 T11582 arg1Of investigated,then
R9472 T11587 T11586 arg1Of described,previously
R9473 T11588 T11585 arg1Of down-regulation,the
R9474 T11588 T11587 arg1Of down-regulation,described
R9475 T11588 T11589 arg1Of down-regulation,of
R9476 T11588 T11596 arg1Of down-regulation,was
R9477 T11588 T11597 arg1Of down-regulation,due
R9478 T11591 T11589 arg2Of expression,of
R9479 T11591 T11590 arg1Of expression,IRF-4
R948 T1282 T1283 arg1Of genes,(
R9480 T11591 T11592 arg1Of expression,in
R9481 T11595 T11592 arg2Of leukemias,in
R9482 T11595 T11593 arg1Of leukemias,human
R9483 T11595 T11594 arg1Of leukemias,myeloid
R9484 T11596 T11583 arg2Of was,investigated
R9485 T11596 T11584 arg1Of was,whether
R9486 T11596 T11605 arg1Of was,","
R9487 T11596 T11606 arg1Of was,since
R9488 T11597 T11596 arg2Of due,was
R9489 T11597 T11598 arg1Of due,to
R949 T1282 T1285 arg1Of genes,as
R9490 T11601 T11598 arg2Of hypermethylation,to
R9491 T11601 T11599 arg1Of hypermethylation,a
R9492 T11601 T11600 arg1Of hypermethylation,differential
R9493 T11601 T11602 arg1Of hypermethylation,of
R9494 T11604 T11602 arg2Of promoter,of
R9495 T11604 T11603 arg1Of promoter,the
R9496 T11609 T11607 arg1Of re-expression,the
R9497 T11609 T11608 arg2Of re-expression,presented
R9498 T11609 T11610 arg1Of re-expression,due
R9499 T11609 T11613 arg1Of re-expression,might
R950 T1285 T1284 arg1Of as,such
R9500 T11609 T11615 arg1Of re-expression,be
R9501 T11610 T11611 arg1Of due,to
R9502 T11612 T11610 arg2Of AzadC-treatment,due
R9503 T11615 T11606 arg2Of be,since
R9504 T11615 T11613 arg2Of be,might
R9505 T11615 T11614 arg1Of be,also
R9506 T11617 T11615 arg2Of result,be
R9507 T11617 T11616 arg1Of result,a
R9508 T11617 T11618 arg1Of result,of
R9509 T11619 T11618 arg2Of activation,of
R951 T1286 T1287 arg1Of IFNs,","
R9510 T11619 T11620 arg1Of activation,of
R9511 T11623 T11620 arg2Of regulators,of
R9512 T11623 T11621 arg1Of regulators,positive
R9513 T11623 T11622 arg1Of regulators,transcriptional
R9514 T11623 T11624 arg1Of regulators,of
R9515 T11625 T11624 arg2Of IRF-4,of
R9516 T11626 T11627 arg1Of Methylation,of
R9517 T11626 T11630 arg1Of Methylation,is
R9518 T11626 T11640 arg1Of Methylation,has
R9519 T11626 T11642 arg1Of Methylation,been
R952 T1287 T1289 arg1Of ",",","
R9520 T11626 T11643 arg2Of Methylation,shown
R9521 T11629 T11627 arg2Of sites,of
R9522 T11629 T11628 arg1Of sites,CpG
R9523 T11630 T11639 arg1Of is,and
R9524 T11633 T11630 arg2Of mechanism,is
R9525 T11633 T11631 arg1Of mechanism,a
R9526 T11633 T11632 arg1Of mechanism,common
R9527 T11633 T11634 arg1Of mechanism,of
R9528 T11633 T11637 arg1Of mechanism,in
R9529 T11636 T11634 arg2Of genes,of
R953 T1288 T1287 arg2Of interleukins,","
R9530 T11636 T11635 arg1Of genes,silencing
R9531 T11638 T11637 arg2Of leukemia,in
R9532 T11643 T11639 arg2Of shown,and
R9533 T11643 T11640 arg2Of shown,has
R9534 T11643 T11641 arg1Of shown,also
R9535 T11643 T11642 arg2Of shown,been
R9536 T11643 T11644 arg1Of shown,for
R9537 T11643 T11653 arg1Of shown,for
R9538 T11644 T11652 arg1Of for,and
R9539 T11646 T11645 arg1Of IRF,another
R954 T1289 T1285 arg2Of ",",as
R9540 T11646 T11647 arg1Of IRF,","
R9541 T11647 T11644 arg2Of ",",for
R9542 T11648 T11647 arg2Of IRF-7,","
R9543 T11648 T11649 arg1Of IRF-7,(
R9544 T11650 T11649 arg2Of 35,(
R9545 T11651 T11649 arg3Of ),(
R9546 T11653 T11652 arg2Of for,and
R9547 T11654 T11653 arg2Of PU.1,for
R9548 T11654 T11655 arg1Of PU.1,(
R9549 T11654 T11658 arg1Of PU.1,","
R955 T1292 T1289 arg2Of I/II,","
R9550 T11656 T11655 arg2Of 36,(
R9551 T11657 T11655 arg3Of ),(
R9552 T11661 T11658 arg2Of partner,","
R9553 T11661 T11659 arg1Of partner,an
R9554 T11661 T11660 arg1Of partner,interacting
R9555 T11661 T11662 arg1Of partner,of
R9556 T11663 T11662 arg2Of IRF-4,of
R9557 T11665 T11664 arg1Of elucidate,To
R9558 T11665 T11688 arg1Of elucidate,were
R9559 T11665 T11689 arg2Of elucidate,sequenced
R956 T1292 T1290 arg1Of I/II,MHC
R9560 T11667 T11665 arg2Of relevance,elucidate
R9561 T11667 T11666 arg1Of relevance,the
R9562 T11667 T11668 arg1Of relevance,of
R9563 T11670 T11668 arg2Of mechanism,of
R9564 T11670 T11669 arg1Of mechanism,this
R9565 T11670 T11671 arg1Of mechanism,for
R9566 T11673 T11671 arg2Of regulation,for
R9567 T11673 T11672 arg1Of regulation,the
R9568 T11673 T11674 arg1Of regulation,of
R9569 T11676 T11674 arg2Of expression,of
R957 T1292 T1291 arg1Of I/II,class
R9570 T11676 T11675 arg1Of expression,IRF-4
R9571 T11680 T11678 arg1Of cells,various
R9572 T11680 T11679 arg1Of cells,leukemic
R9573 T11680 T11681 arg1Of cells,were
R9574 T11680 T11682 arg2Of cells,treated
R9575 T11682 T11681 arg2Of treated,were
R9576 T11682 T11683 arg1Of treated,with
R9577 T11685 T11686 arg1Of agents,and
R9578 T11686 T11683 arg2Of and,with
R9579 T11686 T11684 arg1Of and,demethylating
R958 T1292 T1293 arg1Of I/II,)
R9580 T11687 T11686 arg2Of promoters,and
R9581 T11689 T11677 arg1Of sequenced,","
R9582 T11689 T11681 modOf sequenced,were
R9583 T11689 T11688 arg2Of sequenced,were
R9584 T11689 T11690 arg1Of sequenced,after
R9585 T11692 T11690 arg2Of treatment,after
R9586 T11692 T11691 arg1Of treatment,bisulfite
R9587 T11693 T11694 arg1Of We,found
R9588 T11697 T11696 arg1Of expression,IRF-4
R9589 T11697 T11698 arg1Of expression,could
R959 T1294 T1277 arg2Of ",",in
R9590 T11697 T11700 arg1Of expression,be
R9591 T11697 T11701 arg2Of expression,connected
R9592 T11701 T11694 arg2Of connected,found
R9593 T11701 T11695 arg1Of connected,that
R9594 T11701 T11698 arg2Of connected,could
R9595 T11701 T11699 arg1Of connected,indeed
R9596 T11701 T11700 arg2Of connected,be
R9597 T11701 T11702 arg1Of connected,to
R9598 T11705 T11702 arg2Of status,to
R9599 T11705 T11703 arg1Of status,the
R960 T1294 T1278 arg1Of ",",the
R9600 T11705 T11704 arg1Of status,methylation
R9601 T11705 T11706 arg1Of status,of
R9602 T11709 T11706 arg2Of motifs,of
R9603 T11709 T11707 arg1Of motifs,distinct
R9604 T11709 T11708 arg1Of motifs,CpG
R9605 T11709 T11710 arg1Of motifs,in
R9606 T11713 T11710 arg2Of promoter,in
R9607 T11713 T11711 arg1Of promoter,the
R9608 T11713 T11712 arg1Of promoter,IRF-4
R9609 T11716 T11714 arg2Of 4A,In
R961 T1295 T1296 arg1Of apoptosis,and
R9610 T11716 T11715 arg1Of 4A,Figure
R9611 T11720 T11718 arg1Of sites,those
R9612 T11720 T11719 arg1Of sites,CpG
R9613 T11720 T11721 arg1Of sites,are
R9614 T11720 T11722 arg2Of sites,shown
R9615 T11722 T11714 arg1Of shown,In
R9616 T11722 T11717 arg1Of shown,","
R9617 T11722 T11721 arg2Of shown,are
R9618 T11722 T11723 arg1Of shown,(
R9619 T11722 T11727 arg1Of shown,","
R962 T1296 T1294 arg2Of and,","
R9620 T11725 T11723 arg2Of line,(
R9621 T11725 T11724 arg1Of line,bottom
R9622 T11726 T11723 arg3Of ),(
R9623 T11728 T11722 arg3Of whose,shown
R9624 T11729 T11728 arg1Of hypermethylation,whose
R9625 T11729 T11730 arg1Of hypermethylation,may
R9626 T11729 T11731 arg1Of hypermethylation,account
R9627 T11731 T11730 arg2Of account,may
R9628 T11731 T11732 arg1Of account,for
R9629 T11734 T11732 arg2Of absence,for
R963 T1296 T1298 arg1Of and,(
R9630 T11734 T11733 arg1Of absence,the
R9631 T11734 T11735 arg1Of absence,of
R9632 T11737 T11735 arg2Of expression,of
R9633 T11737 T11736 arg1Of expression,IRF-4
R9634 T11737 T11738 arg1Of expression,in
R9635 T11741 T11738 arg2Of cells,in
R9636 T11741 T11739 arg1Of cells,the
R9637 T11741 T11740 arg1Of cells,respective
R9638 T11742 T11743 arg1Of One,of
R9639 T11742 T11749 arg1Of One,is
R964 T1297 T1296 arg2Of differentiation/maturation,and
R9640 T11744 T11743 arg2Of them,of
R9641 T11744 T11745 arg1Of them,(
R9642 T11747 T11745 arg2Of 54,(
R9643 T11747 T11746 arg1Of 54,#
R9644 T11748 T11745 arg3Of ),(
R9645 T11749 T11759 arg1Of is,","
R9646 T11749 T11760 modOf is,indicating
R9647 T11750 T11749 arg2Of adjacent,is
R9648 T11750 T11751 arg1Of adjacent,to
R9649 T11755 T11751 arg2Of element,to
R965 T1299 T1298 arg2Of 4–6,(
R9650 T11755 T11752 arg1Of element,an
R9651 T11755 T11753 arg2Of element,identified
R9652 T11755 T11754 arg1Of element,regulatory
R9653 T11755 T11756 arg1Of element,(
R9654 T11757 T11756 arg2Of NFκB-site,(
R9655 T11758 T11756 arg3Of ),(
R9656 T11763 T11760 arg2Of involvement,indicating
R9657 T11763 T11761 arg1Of involvement,a
R9658 T11763 T11762 arg1Of involvement,possible
R9659 T11763 T11764 arg1Of involvement,of
R966 T1300 T1298 arg3Of ),(
R9660 T11766 T11764 arg2Of site,of
R9661 T11766 T11765 arg1Of site,this
R9662 T11771 T11767 arg2Of sites,At
R9663 T11771 T11768 arg1Of sites,two
R9664 T11771 T11769 arg1Of sites,further
R9665 T11771 T11770 arg1Of sites,CpG
R9666 T11771 T11772 arg1Of sites,(
R9667 T11774 T11772 arg2Of 48,(
R9668 T11774 T11773 arg1Of 48,#
R9669 T11774 T11775 arg1Of 48,","
R967 T1301 T1302 arg1Of IRF-4,(
R9670 T11776 T11775 arg2Of 45,","
R9671 T11777 T11772 arg3Of ),(
R9672 T11780 T11778 arg1Of status,the
R9673 T11780 T11779 arg1Of status,methylation
R9674 T11780 T11781 arg1Of status,in
R9675 T11780 T11783 arg1Of status,was
R9676 T11780 T11784 arg1Of status,lower
R9677 T11782 T11781 arg2Of IRF-4-positive,in
R9678 T11783 T11767 arg1Of was,At
R9679 T11784 T11783 arg2Of lower,was
R968 T1301 T1305 arg1Of IRF-4,is
R9680 T11784 T11785 arg1Of lower,than
R9681 T11786 T11785 arg2Of that,than
R9682 T11786 T11787 arg1Of that,of
R9683 T11789 T11787 arg2Of cells,of
R9684 T11789 T11788 arg1Of cells,IRF-4-negative
R9685 T11792 T11790 arg1Of sites,These
R9686 T11792 T11791 arg1Of sites,CpG
R9687 T11792 T11793 arg1Of sites,are
R9688 T11792 T11794 arg1Of sites,located
R9689 T11792 T11807 arg1Of sites,may
R969 T1303 T1302 arg2Of ICSAT/Pip/MUM1/LSIRF,(
R9690 T11792 T11809 arg1Of sites,play
R9691 T11793 T11805 arg1Of are,and
R9692 T11794 T11793 arg2Of located,are
R9693 T11794 T11795 arg1Of located,in
R9694 T11797 T11796 arg1Of NFκB,an
R9695 T11797 T11798 arg1Of NFκB,and
R9696 T11798 T11795 arg2Of and,in
R9697 T11801 T11798 arg2Of element,and
R9698 T11801 T11799 arg1Of element,an
R9699 T11801 T11800 arg1Of element,SP1
R970 T1304 T1302 arg3Of ),(
R9700 T11801 T11802 arg1Of element,(
R9701 T11803 T11802 arg2Of 31,(
R9702 T11804 T11802 arg3Of ),(
R9703 T11809 T11805 arg2Of play,and
R9704 T11809 T11806 arg1Of play,thus
R9705 T11809 T11807 arg2Of play,may
R9706 T11809 T11808 arg1Of play,also
R9707 T11809 T11812 arg1Of play,in
R9708 T11811 T11809 arg2Of role,play
R9709 T11811 T11810 arg1Of role,a
R971 T1307 T1305 arg2Of member,is
R9710 T11813 T11812 arg2Of regulation,in
R9711 T11813 T11814 arg1Of regulation,of
R9712 T11816 T11814 arg2Of expression,of
R9713 T11816 T11815 arg1Of expression,IRF-4
R9714 T11817 T11818 arg1Of It,has
R9715 T11817 T11819 arg1Of It,been
R9716 T11817 T11820 arg2Of It,shown
R9717 T11820 T11818 arg2Of shown,has
R9718 T11820 T11819 arg2Of shown,been
R9719 T11823 T11822 arg1Of elements,NFκB
R972 T1307 T1306 arg1Of member,one
R9720 T11823 T11824 arg1Of elements,play
R9721 T11824 T11820 arg3Of play,shown
R9722 T11824 T11821 arg1Of play,that
R9723 T11824 T11828 arg1Of play,in
R9724 T11824 T11831 arg1Of play,as
R9725 T11827 T11824 arg2Of role,play
R9726 T11827 T11825 arg1Of role,an
R9727 T11827 T11826 arg1Of role,important
R9728 T11830 T11828 arg2Of induction,in
R9729 T11830 T11829 arg1Of induction,IRF-4
R973 T1307 T1308 arg1Of member,with
R9730 T11833 T11832 arg1Of expression,IRF-4
R9731 T11833 T11834 arg1Of expression,depends
R9732 T11834 T11831 arg2Of depends,as
R9733 T11834 T11835 arg1Of depends,on
R9734 T11836 T11835 arg2Of binding,on
R9735 T11836 T11837 arg1Of binding,of
R9736 T11836 T11841 arg1Of binding,to
R9737 T11840 T11837 arg2Of c-Rel,of
R9738 T11840 T11838 arg1Of c-Rel,the
R9739 T11840 T11839 arg1Of c-Rel,transactivator
R974 T1307 T1313 arg1Of member,:
R9740 T11843 T11841 arg2Of elements,to
R9741 T11843 T11842 arg1Of elements,these
R9742 T11843 T11844 arg1Of elements,in
R9743 T11847 T11844 arg2Of promoter,in
R9744 T11847 T11845 arg1Of promoter,the
R9745 T11847 T11846 arg1Of promoter,IRF-4
R9746 T11847 T11848 arg1Of promoter,(
R9747 T11849 T11848 arg2Of "31,37",(
R9748 T11850 T11848 arg3Of ),(
R9749 T11853 T11854 arg1Of methylation,of
R975 T1310 T1309 arg1Of restricted,very
R9750 T11853 T11862 arg1Of methylation,inhibits
R9751 T11857 T11854 arg2Of CpG,of
R9752 T11857 T11855 arg1Of CpG,the
R9753 T11857 T11856 arg1Of CpG,central
R9754 T11857 T11858 arg1Of CpG,in
R9755 T11861 T11858 arg2Of element,in
R9756 T11861 T11859 arg1Of element,the
R9757 T11861 T11860 arg1Of element,NFκB
R9758 T11862 T11851 arg1Of inhibits,Furthermore
R9759 T11862 T11852 arg1Of inhibits,","
R976 T1312 T1308 arg2Of pattern,with
R9760 T11862 T11872 arg1Of inhibits,","
R9761 T11863 T11862 arg2Of binding,inhibits
R9762 T11863 T11864 arg1Of binding,of
R9763 T11868 T11864 arg2Of complexes,of
R9764 T11868 T11865 arg1Of complexes,the
R9765 T11868 T11866 arg1Of complexes,NFκB
R9766 T11868 T11867 arg1Of complexes,protein
R9767 T11868 T11869 arg1Of complexes,(
R9768 T11870 T11869 arg2Of 38,(
R9769 T11871 T11869 arg3Of ),(
R977 T1312 T1310 arg1Of pattern,restricted
R9770 T11873 T11862 arg3Of promoting,inhibits
R9771 T11875 T11873 arg2Of significance,promoting
R9772 T11875 T11874 arg1Of significance,the
R9773 T11875 T11876 arg1Of significance,of
R9774 T11880 T11876 arg2Of differences,of
R9775 T11880 T11877 arg1Of differences,the
R9776 T11880 T11878 arg2Of differences,observed
R9777 T11880 T11879 arg1Of differences,methylation
R9778 T11880 T11881 arg1Of differences,in
R9779 T11882 T11883 arg1Of IRF-4-positive,and
R978 T1312 T1311 arg1Of pattern,expression
R9780 T11884 T11883 arg2Of -negative,and
R9781 T11885 T11881 arg2Of cells,in
R9782 T11885 T11882 arg1Of cells,IRF-4-positive
R9783 T11885 T11884 arg1Of cells,-negative
R9784 T11888 T11887 arg1Of vitro,in
R9785 T11889 T11890 arg1Of methylation,and
R9786 T11891 T11890 arg2Of reporter,and
R9787 T11893 T11886 arg2Of assays,Via
R9788 T11893 T11888 arg1Of assays,vitro
R9789 T11893 T11889 arg1Of assays,methylation
R979 T1315 T1314 arg1Of B-,Predominately
R9790 T11893 T11891 arg1Of assays,reporter
R9791 T11893 T11892 arg1Of assays,gene
R9792 T11894 T11895 arg1Of we,could
R9793 T11894 T11897 arg1Of we,appoint
R9794 T11897 T11886 modOf appoint,Via
R9795 T11897 T11895 arg2Of appoint,could
R9796 T11897 T11896 arg1Of appoint,clearly
R9797 T11897 T11904 arg1Of appoint,to
R9798 T11899 T11897 arg2Of silencing,appoint
R9799 T11899 T11898 arg1Of silencing,the
R980 T1315 T1316 arg1Of B-,and
R9800 T11899 T11900 arg1Of silencing,of
R9801 T11903 T11900 arg2Of promoter,of
R9802 T11903 T11901 arg1Of promoter,the
R9803 T11903 T11902 arg1Of promoter,IRF-4
R9804 T11907 T11904 arg2Of effect,to
R9805 T11907 T11905 arg1Of effect,a
R9806 T11907 T11906 arg1Of effect,methylation
R9807 T11907 T11908 arg1Of effect,","
R9808 T11907 T11909 arg1Of effect,which
R9809 T11907 T11910 arg1Of effect,may
R981 T1316 T1319 arg1Of and,are
R9810 T11907 T11912 arg1Of effect,be
R9811 T11912 T11910 arg2Of be,may
R9812 T11912 T11911 arg1Of be,thus
R9813 T11912 T11919 arg1Of be,vivo
R9814 T11914 T11912 arg2Of mechanism,be
R9815 T11914 T11913 arg1Of mechanism,the
R9816 T11914 T11915 arg1Of mechanism,of
R9817 T11917 T11915 arg2Of deregulation,of
R9818 T11917 T11916 arg1Of deregulation,IRF-4
R9819 T11919 T11918 arg1Of vivo,in
R982 T1318 T1316 arg2Of T-lymphocytes,and
R9820 T11922 T11920 arg1Of cause,One
R9821 T11922 T11921 arg1Of cause,possible
R9822 T11922 T11923 arg1Of cause,for
R9823 T11922 T11929 arg1Of cause,is
R9824 T11926 T11923 arg2Of methylation,for
R9825 T11926 T11924 arg1Of methylation,the
R9826 T11926 T11925 arg1Of methylation,aberrant
R9827 T11926 T11927 arg1Of methylation,in
R9828 T11928 T11927 arg2Of tumorigenesis,in
R9829 T11932 T11929 arg2Of level,is
R983 T1318 T1317 arg2Of T-lymphocytes,activated
R9830 T11932 T11930 arg1Of level,an
R9831 T11932 T11931 arg2Of level,increased
R9832 T11932 T11933 arg1Of level,of
R9833 T11932 T11935 arg1Of level,during
R9834 T11934 T11933 arg2Of DNMTs,of
R9835 T11938 T11935 arg2Of process,during
R9836 T11938 T11936 arg1Of process,the
R9837 T11938 T11937 arg1Of process,pathogenetic
R9838 T11940 T11941 arg1Of colon,","
R9839 T11941 T11943 arg1Of ",",and
R984 T1320 T1319 arg2Of IRF-4,are
R9840 T11942 T11941 arg2Of lung,","
R9841 T11943 T11939 arg2Of and,In
R9842 T11945 T11943 arg2Of malignancies,and
R9843 T11945 T11944 arg1Of malignancies,hematologic
R9844 T11947 T11948 arg1Of overexpression,of
R9845 T11947 T11955 arg1Of overexpression,has
R9846 T11947 T11956 arg1Of overexpression,been
R9847 T11947 T11957 arg2Of overexpression,detected
R9848 T11949 T11948 arg2Of DNMT1,of
R9849 T11949 T11950 arg1Of DNMT1,","
R985 T1320 T1321 arg1Of IRF-4,positive
R9850 T11953 T11950 arg2Of DNMT,","
R9851 T11953 T11951 arg1Of DNMT,a
R9852 T11953 T11952 arg1Of DNMT,maintenance
R9853 T11957 T11939 arg1Of detected,In
R9854 T11957 T11946 arg1Of detected,","
R9855 T11957 T11954 arg1Of detected,","
R9856 T11957 T11955 arg2Of detected,has
R9857 T11957 T11956 arg2Of detected,been
R9858 T11957 T11958 arg1Of detected,(
R9859 T11959 T11958 arg2Of 39–41,(
R986 T1320 T1322 arg1Of IRF-4,(
R9860 T11960 T11958 arg3Of ),(
R9861 T11963 T11964 arg1Of it,has
R9862 T11963 T11965 arg1Of it,been
R9863 T11963 T11966 arg2Of it,shown
R9864 T11966 T11961 arg1Of shown,Furthermore
R9865 T11966 T11962 arg1Of shown,","
R9866 T11966 T11964 arg2Of shown,has
R9867 T11966 T11965 arg2Of shown,been
R9868 T11969 T11968 arg1Of cells,CML
R9869 T11969 T11970 arg1Of cells,in
R987 T1323 T1322 arg2Of 7–11,(
R9870 T11969 T11974 arg1Of cells,exhibited
R9871 T11973 T11970 arg2Of phase,in
R9872 T11973 T11971 arg1Of phase,the
R9873 T11973 T11972 arg1Of phase,acute
R9874 T11974 T11966 arg3Of exhibited,shown
R9875 T11974 T11967 arg1Of exhibited,that
R9876 T11974 T11982 arg1Of exhibited,","
R9877 T11974 T11983 arg1Of exhibited,while
R9878 T11976 T11974 arg2Of levels,exhibited
R9879 T11976 T11975 arg1Of levels,elevated
R988 T1324 T1322 arg3Of ),(
R9880 T11976 T11977 arg1Of levels,of
R9881 T11981 T11977 arg2Of DNMTs,of
R9882 T11981 T11978 arg1Of DNMTs,the
R9883 T11981 T11979 arg1Of DNMTs,three
R9884 T11981 T11980 arg2Of DNMTs,known
R9885 T11985 T11984 arg1Of cells,CML
R9886 T11985 T11986 arg1Of cells,in
R9887 T11985 T11989 arg1Of cells,expressed
R9888 T11988 T11986 arg2Of phase,in
R9889 T11988 T11987 arg1Of phase,chronic
R989 T1326 T1325 arg2Of contrast,In
R9890 T11989 T11983 arg2Of expressed,while
R9891 T11989 T11994 arg1Of expressed,if
R9892 T11991 T11989 arg2Of levels,expressed
R9893 T11991 T11990 arg1Of levels,normal
R9894 T11991 T11992 arg1Of levels,of
R9895 T11993 T11992 arg2Of DNMTs,of
R9896 T11995 T11994 arg2Of compared,if
R9897 T11995 T11996 arg1Of compared,with
R9898 T12000 T11996 arg2Of cells,with
R9899 T12000 T11997 arg1Of cells,normal
R990 T1326 T1327 arg1Of contrast,to
R9900 T12000 T11998 arg1Of cells,bone
R9901 T12000 T11999 arg1Of cells,marrow
R9902 T12000 T12001 arg1Of cells,(
R9903 T12002 T12001 arg2Of 25,(
R9904 T12003 T12001 arg3Of ),(
R9905 T12008 T12006 arg1Of correlation,a
R9906 T12008 T12007 arg1Of correlation,positive
R9907 T12008 T12009 arg1Of correlation,between
R9908 T12008 T12017 arg1Of correlation,has
R9909 T12008 T12018 arg1Of correlation,been
R991 T1329 T1327 arg2Of IRFs,to
R9910 T12008 T12019 arg2Of correlation,detected
R9911 T12012 T12010 arg1Of levels,DNMT1
R9912 T12012 T12011 arg1Of levels,expression
R9913 T12012 T12013 arg1Of levels,and
R9914 T12013 T12009 arg2Of and,between
R9915 T12014 T12013 arg2Of hypermethylation,and
R9916 T12014 T12015 arg1Of hypermethylation,of
R9917 T12016 T12015 arg2Of p15INK4b,of
R9918 T12019 T12004 arg1Of detected,Interestingly
R9919 T12019 T12005 arg1Of detected,","
R992 T1329 T1328 arg1Of IRFs,other
R9920 T12019 T12017 arg2Of detected,has
R9921 T12019 T12018 arg2Of detected,been
R9922 T12019 T12020 arg1Of detected,in
R9923 T12021 T12020 arg2Of AML,in
R9924 T12021 T12022 arg1Of AML,(
R9925 T12023 T12022 arg2Of 25,(
R9926 T12024 T12022 arg3Of ),(
R9927 T12027 T12025 arg2Of work,In
R9928 T12027 T12026 arg1Of work,this
R9929 T12029 T12030 arg1Of we,did
R993 T1331 T1332 arg1Of expression,of
R9930 T12029 T12032 arg1Of we,detect
R9931 T12032 T12025 arg1Of detect,In
R9932 T12032 T12028 arg1Of detect,","
R9933 T12032 T12030 arg2Of detect,did
R9934 T12032 T12031 arg1Of detect,not
R9935 T12032 T12042 arg1Of detect,","
R9936 T12032 T12043 modOf detect,making
R9937 T12036 T12032 arg2Of differences,detect
R9938 T12036 T12033 arg1Of differences,significant
R9939 T12036 T12034 arg1Of differences,mRNA
R994 T1331 T1334 arg1Of expression,can
R9940 T12036 T12035 arg1Of differences,expression
R9941 T12036 T12037 arg1Of differences,of
R9942 T12039 T12040 arg1Of DNMT,or
R9943 T12040 T12037 arg2Of or,of
R9944 T12040 T12038 arg2Of or,selected
R9945 T12041 T12040 arg2Of MBP,or
R9946 T12044 T12043 arg2Of it,making
R9947 T12047 T12043 arg3Of cause,making
R9948 T12047 T12045 arg1Of cause,an
R9949 T12047 T12046 arg1Of cause,unlikely
R995 T1331 T1336 arg1Of expression,be
R9950 T12047 T12048 arg1Of cause,for
R9951 T12051 T12050 arg2Of methylation,observed
R9952 T12051 T12052 arg1Of methylation,and
R9953 T12052 T12048 arg2Of and,for
R9954 T12052 T12049 arg1Of and,the
R9955 T12052 T12057 arg1Of and,in
R9956 T12056 T12052 arg2Of differences,and
R9957 T12056 T12053 arg1Of differences,thus
R9958 T12056 T12054 arg1Of differences,IRF-4
R9959 T12056 T12055 arg1Of differences,expression
R996 T1331 T1337 arg2Of expression,induced
R9960 T12059 T12057 arg2Of cells,in
R9961 T12059 T12058 arg1Of cells,leukemia
R9962 T12061 T12060 arg1Of finding,The
R9963 T12061 T12070 arg1Of finding,might
R9964 T12061 T12071 arg1Of finding,represent
R9965 T12064 T12063 arg1Of expression,IRF-4
R9966 T12064 T12065 arg1Of expression,is
R9967 T12064 T12066 arg2Of expression,silenced
R9968 T12066 T12061 arg2Of silenced,finding
R9969 T12066 T12062 arg1Of silenced,that
R997 T1333 T1332 arg2Of IRF-4,of
R9970 T12066 T12065 arg2Of silenced,is
R9971 T12069 T12066 arg1Of hypermethylation,silenced
R9972 T12069 T12067 arg2Of hypermethylation,by
R9973 T12069 T12068 arg1Of hypermethylation,promoter
R9974 T12071 T12070 arg2Of represent,might
R9975 T12073 T12071 arg2Of mechanism,represent
R9976 T12073 T12072 arg1Of mechanism,a
R9977 T12073 T12074 arg1Of mechanism,that
R9978 T12073 T12075 arg1Of mechanism,accounts
R9979 T12075 T12076 arg1Of accounts,for
R998 T1337 T1325 arg1Of induced,In
R9980 T12079 T12078 arg1Of observed,previously
R9981 T12080 T12076 arg2Of loss,for
R9982 T12080 T12077 arg1Of loss,the
R9983 T12080 T12079 arg1Of loss,observed
R9984 T12080 T12081 arg1Of loss,of
R9985 T12083 T12081 arg2Of expression,of
R9986 T12083 T12082 arg1Of expression,IRF-4
R9987 T12083 T12084 arg1Of expression,in
R9988 T12085 T12084 arg2Of CML,in
R9989 T12090 T12088 arg1Of trials,several
R999 T1337 T1330 arg1Of induced,","
R9990 T12090 T12089 arg1Of trials,clinical
R9991 T12090 T12091 arg1Of trials,with
R9992 T12090 T12099 arg1Of trials,demonstrated
R9993 T12093 T12092 arg1Of patients,leukemia
R9994 T12093 T12094 arg1Of patients,and
R9995 T12094 T12091 arg2Of and,with
R9996 T12095 T12094 arg2Of patients,and
R9997 T12095 T12096 arg1Of patients,with
R9998 T12098 T12096 arg2Of syndromes,with
R9999 T12098 T12097 arg1Of syndromes,myelodysplastic