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PMC:1064895 / 2407-5647 JSONTXT 27 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T2893 13-23 JJ denotes Rheumatoid
T2894 24-33 NN denotes arthritis
T2895 34-35 -LRB- denotes (
T2896 35-37 NN denotes RA
T2897 37-38 -RRB- denotes )
T2898 39-41 VB denotes is
T2899 42-55 VB denotes characterized
T2900 56-58 IN denotes by
T2901 59-72 NN denotes infiltrations
T2902 73-75 IN denotes of
T2903 76-87 NN denotes macrophages
T2904 88-91 CC denotes and
T2905 92-93 NN denotes T
T2906 94-99 NN denotes cells
T2907 100-104 IN denotes into
T2908 105-108 DT denotes the
T2909 109-114 NN denotes joint
T2910 114-115 -COMMA- denotes ,
T2911 116-119 CC denotes and
T2912 120-128 JJ denotes synovial
T2913 129-140 NN denotes hyperplasia
T2914 142-157 JJ denotes Proinflammatory
T2915 158-167 NN denotes cytokines
T2916 168-176 VB denotes released
T2917 177-181 IN denotes from
T2918 182-187 DT denotes these
T2919 188-193 NN denotes cells
T2920 194-197 VB denotes are
T2921 198-203 VB denotes known
T2922 204-206 TO denotes to
T2923 207-209 VB denotes be
T2924 210-219 JJ denotes important
T2925 220-222 IN denotes in
T2926 223-226 DT denotes the
T2927 227-238 NN denotes destruction
T2928 239-241 IN denotes of
T2929 242-248 NN denotes joints
T2930 249-251 IN denotes in
T2931 252-254 NN denotes RA
T2932 255-256 -LRB- denotes [
T2933 256-257 CD denotes 1
T2934 257-258 -RRB- denotes ]
T2935 260-263 DT denotes The
T2936 264-273 JJ denotes favorable
T2937 274-282 JJ denotes clinical
T2938 283-291 NN denotes benefits
T2939 292-300 VB denotes obtained
T2940 301-305 IN denotes with
T2941 306-316 NN denotes inhibitors
T2942 317-319 IN denotes of
T2943 320-325 NN denotes tumor
T2944 326-334 NN denotes necrosis
T2945 335-341 NN denotes factor
T2946 342-343 -LRB- denotes (
T2947 343-346 NN denotes TNF
T2948 346-347 -RRB- denotes )
T2949 347-349 NN denotes -α
T2950 349-350 -RRB- denotes )
T2951 351-354 CC denotes and
T2952 355-366 NN denotes interleukin
T2953 367-368 -LRB- denotes (
T2954 368-370 NN denotes IL
T2955 370-371 -RRB- denotes )
T2956 371-373 CD denotes -1
T2957 374-381 VB denotes suggest
T2958 382-386 IN denotes that
T2959 387-390 DT denotes the
T2960 391-399 NN denotes blockade
T2961 400-402 IN denotes of
T2962 403-406 JJ denotes key
T2963 407-419 JJ denotes inflammatory
T2964 420-429 NN denotes cytokines
T2965 430-433 VB denotes has
T2966 434-438 VB denotes been
T2967 439-442 DT denotes the
T2968 443-452 JJ denotes important
T2969 453-458 NN denotes issue
T2970 459-461 IN denotes in
T2971 462-465 DT denotes the
T2972 466-477 NN denotes development
T2973 478-480 IN denotes of
T2974 481-484 JJ denotes new
T2975 485-496 JJ denotes therapeutic
T2976 497-509 NN denotes applications
T2977 510-511 -LRB- denotes [
T2978 511-512 CD denotes 2
T2979 512-513 -RRB- denotes ]
T2980 515-516 DT denotes A
T2981 517-523 JJ denotes little
T2982 524-528 IN denotes over
T2983 529-530 DT denotes a
T2984 531-537 NN denotes decade
T2985 538-541 RB denotes ago
T2986 541-542 -COMMA- denotes ,
T2987 543-546 DT denotes the
T2988 547-554 NN denotes primacy
T2989 555-557 IN denotes of
T2990 558-559 NN denotes T
T2991 560-565 NN denotes cells
T2992 566-568 IN denotes in
T2993 569-572 DT denotes the
T2994 573-585 NN denotes pathogenesis
T2995 586-588 IN denotes of
T2996 589-599 JJ denotes autoimmune
T2997 600-607 NN denotes disease
T2998 608-612 JJ denotes such
T2999 613-615 IN denotes as
T3000 616-618 NN denotes RA
T3001 619-622 VB denotes was
T3002 623-633 JJ denotes undisputed
T3003 634-641 IN denotes because
T3004 642-646 PRP denotes they
T3005 647-650 VB denotes are
T3006 651-654 DT denotes the
T3007 655-662 JJ denotes largest
T3008 663-667 NN denotes cell
T3009 668-678 NN denotes population
T3010 679-691 VB denotes infiltrating
T3011 692-695 DT denotes the
T3012 696-704 NN denotes synovium
T3013 706-713 RB denotes However
T3014 713-714 -COMMA- denotes ,
T3015 715-716 DT denotes a
T3016 717-723 NN denotes series
T3017 724-726 IN denotes of
T3018 727-734 NN denotes studies
T3019 735-747 VB denotes demonstrated
T3020 748-755 NN denotes paucity
T3021 756-758 IN denotes of
T3022 759-760 NN denotes T
T3023 761-773 JJ denotes cell-derived
T3024 774-783 NN denotes cytokines
T3025 784-788 JJ denotes such
T3026 789-791 IN denotes as
T3027 792-796 NN denotes IL-2
T3028 797-800 CC denotes and
T3029 801-813 NN denotes interferon-γ
T3030 814-816 IN denotes in
T3031 817-820 DT denotes the
T3032 821-827 NN denotes joints
T3033 828-830 IN denotes of
T3034 831-833 NN denotes RA
T3035 833-834 -COMMA- denotes ,
T3036 835-842 IN denotes whereas
T3037 843-853 NN denotes macrophage
T3038 854-857 CC denotes and
T3039 858-868 NN denotes fibroblast
T3040 869-878 NN denotes cytokines
T3041 879-888 VB denotes including
T3042 889-893 NN denotes IL-1
T3043 893-894 -COMMA- denotes ,
T3044 895-899 NN denotes IL-6
T3045 899-900 -COMMA- denotes ,
T3046 901-906 NN denotes IL-15
T3047 906-907 -COMMA- denotes ,
T3048 908-913 NN denotes IL-18
T3049 914-917 CC denotes and
T3050 918-923 NN denotes TNF-α
T3051 924-928 VB denotes were
T3052 929-937 JJ denotes abundant
T3053 938-940 IN denotes in
T3054 941-951 JJ denotes rheumatoid
T3055 952-960 NN denotes synovium
T3056 962-966 DT denotes This
T3057 967-974 NN denotes paradox
T3058 975-978 VB denotes has
T3059 979-989 VB denotes questioned
T3060 990-993 DT denotes the
T3061 994-998 NN denotes role
T3062 999-1001 IN denotes of
T3063 1002-1003 NN denotes T
T3064 1004-1009 NN denotes cells
T3065 1010-1012 IN denotes in
T3066 1013-1016 DT denotes the
T3067 1017-1029 NN denotes pathogenesis
T3068 1030-1032 IN denotes of
T3069 1033-1035 NN denotes RA
T3070 1036-1037 -LRB- denotes [
T3071 1037-1038 CD denotes 3
T3072 1038-1039 -RRB- denotes ]
T3073 1041-1048 IN denotes Because
T3074 1049-1051 PRP denotes we
T3075 1052-1056 VB denotes have
T3076 1057-1064 RB denotes already
T3077 1065-1077 VB denotes demonstrated
T3078 1078-1081 DT denotes the
T3079 1082-1090 VB denotes enhanced
T3080 1091-1104 NN denotes proliferation
T3081 1105-1107 IN denotes of
T3082 1108-1115 NN denotes antigen
T3083 1116-1124 JJ denotes specific
T3084 1125-1126 NN denotes T
T3085 1127-1132 NN denotes cells
T3086 1132-1133 -COMMA- denotes ,
T3087 1134-1144 RB denotes especially
T3088 1145-1147 TO denotes to
T3089 1148-1152 NN denotes type
T3090 1153-1155 CD denotes II
T3091 1156-1164 NN denotes collagen
T3092 1164-1165 -COMMA- denotes ,
T3093 1166-1169 CC denotes and
T3094 1170-1173 DT denotes the
T3095 1174-1181 NN denotes skewing
T3096 1182-1184 IN denotes of
T3097 1185-1186 NN denotes T
T3098 1187-1193 NN denotes helper
T3099 1194-1198 NN denotes type
T3100 1199-1200 CD denotes 1
T3101 1201-1202 -LRB- denotes (
T3102 1202-1205 NN denotes Th1
T3103 1205-1206 -RRB- denotes )
T3104 1207-1216 NN denotes cytokines
T3105 1217-1219 IN denotes in
T3106 1220-1222 NN denotes RA
T3107 1223-1224 -LRB- denotes [
T3108 1224-1225 CD denotes 4
T3109 1225-1226 -RRB- denotes ]
T3110 1226-1227 -COMMA- denotes ,
T3111 1228-1231 DT denotes the
T3112 1232-1236 NN denotes role
T3113 1237-1239 IN denotes of
T3114 1240-1241 NN denotes T
T3115 1242-1247 NN denotes cells
T3116 1248-1253 VB denotes needs
T3117 1254-1256 TO denotes to
T3118 1257-1259 VB denotes be
T3119 1260-1270 VB denotes elucidated
T3120 1271-1273 IN denotes in
T3121 1274-1283 JJ denotes different
T3122 1284-1291 NN denotes aspects
T3123 1293-1298 NN denotes IL-17
T3124 1299-1301 VB denotes is
T3125 1302-1305 CD denotes one
T3126 1306-1308 IN denotes of
T3127 1309-1312 DT denotes the
T3128 1313-1325 JJ denotes inflammatory
T3129 1326-1335 NN denotes cytokines
T3130 1336-1344 VB denotes secreted
T3131 1345-1351 RB denotes mainly
T3132 1352-1354 IN denotes by
T3133 1355-1364 VB denotes activated
T3134 1365-1366 NN denotes T
T3135 1367-1372 NN denotes cells
T3136 1372-1373 -COMMA- denotes ,
T3137 1374-1379 WDT denotes which
T3138 1380-1383 MD denotes can
T3139 1384-1390 VB denotes induce
T3140 1391-1395 NN denotes IL-6
T3141 1396-1399 CC denotes and
T3142 1400-1404 NN denotes IL-8
T3143 1405-1407 IN denotes by
T3144 1408-1419 NN denotes fibroblasts
T3145 1420-1421 -LRB- denotes [
T3146 1421-1422 CD denotes 5
T3147 1422-1423 -RRB- denotes ]
T3148 1425-1429 DT denotes This
T3149 1430-1438 NN denotes cytokine
T3150 1439-1441 VB denotes is
T3151 1442-1444 IN denotes of
T3152 1445-1453 NN denotes interest
T3153 1454-1457 IN denotes for
T3154 1458-1461 CD denotes two
T3155 1462-1467 JJ denotes major
T3156 1468-1475 NN denotes reasons
T3157 1475-1476 -COLON- denotes :
T3158 1477-1482 RB denotes first
T3159 1482-1483 -COMMA- denotes ,
T3160 1484-1493 RB denotes similarly
T3161 1494-1496 TO denotes to
T3162 1497-1502 NN denotes TNF-α
T3163 1503-1506 CC denotes and
T3164 1507-1511 NN denotes IL-1
T3165 1511-1512 -COMMA- denotes ,
T3166 1513-1518 NN denotes IL-17
T3167 1519-1522 VB denotes has
T3168 1523-1538 JJ denotes proinflammatory
T3169 1539-1549 NN denotes properties
T3170 1549-1550 -COLON- denotes ;
T3171 1551-1557 RB denotes second
T3172 1557-1558 -COMMA- denotes ,
T3173 1559-1561 PRP denotes it
T3174 1562-1564 VB denotes is
T3175 1565-1573 VB denotes produced
T3176 1574-1576 IN denotes by
T3177 1577-1578 NN denotes T
T3178 1579-1584 NN denotes cells
T3179 1585-1586 -LRB- denotes [
T3180 1586-1587 CD denotes 6
T3181 1587-1588 -RRB- denotes ]
T3182 1590-1596 JJ denotes Recent
T3183 1597-1609 NN denotes observations
T3184 1610-1622 VB denotes demonstrated
T3185 1623-1627 IN denotes that
T3186 1628-1633 NN denotes IL-17
T3187 1634-1637 MD denotes can
T3188 1638-1642 RB denotes also
T3189 1643-1651 VB denotes activate
T3190 1652-1664 JJ denotes osteoclastic
T3191 1665-1669 NN denotes bone
T3192 1670-1680 NN denotes resorption
T3193 1681-1683 IN denotes by
T3194 1684-1687 DT denotes the
T3195 1688-1697 NN denotes induction
T3196 1698-1700 IN denotes of
T3197 1701-1706 NN denotes RANKL
T3198 1707-1708 -LRB- denotes (
T3199 1708-1716 NN denotes receptor
T3200 1717-1726 NN denotes activator
T3201 1727-1729 IN denotes of
T3202 1730-1737 JJ denotes nuclear
T3203 1738-1744 NN denotes factor
T3204 1745-1747 NN denotes κB
T3205 1748-1749 -LRB- denotes [
T3206 1749-1754 NN denotes NF-κB
T3207 1754-1755 -RRB- denotes ]
T3208 1756-1762 NN denotes ligand
T3209 1762-1763 -RRB- denotes )
T3210 1763-1764 -COMMA- denotes ,
T3211 1765-1770 WDT denotes which
T3212 1771-1773 VB denotes is
T3213 1774-1782 VB denotes involved
T3214 1783-1785 IN denotes in
T3215 1786-1790 JJ denotes bony
T3216 1791-1798 NN denotes erosion
T3217 1799-1801 IN denotes in
T3218 1802-1804 NN denotes RA
T3219 1805-1806 -LRB- denotes [
T3220 1806-1807 CD denotes 7
T3221 1807-1808 -RRB- denotes ]
T3222 1810-1812 PRP denotes It
T3223 1813-1817 RB denotes also
T3224 1818-1828 VB denotes stimulates
T3225 1829-1832 DT denotes the
T3226 1833-1843 NN denotes production
T3227 1844-1846 IN denotes of
T3228 1847-1851 NN denotes IL-6
T3229 1852-1855 CC denotes and
T3230 1856-1864 NN denotes leukemia
T3231 1865-1875 JJ denotes inhibitory
T3232 1876-1882 NN denotes factor
T3233 1883-1885 IN denotes by
T3234 1886-1898 NN denotes synoviocytes
T3235 1898-1899 -COMMA- denotes ,
T3236 1900-1903 CC denotes and
T3237 1904-1906 IN denotes of
T3238 1907-1920 NN denotes prostaglandin
T3239 1921-1923 NN denotes E2
T3240 1924-1927 CC denotes and
T3241 1928-1934 JJ denotes nitric
T3242 1935-1940 NN denotes oxide
T3243 1941-1943 IN denotes by
T3244 1944-1956 NN denotes chondrocytes
T3245 1956-1957 -COMMA- denotes ,
T3246 1958-1961 CC denotes and
T3247 1962-1965 VB denotes has
T3248 1966-1969 DT denotes the
T3249 1970-1977 NN denotes ability
T3250 1978-1980 TO denotes to
T3251 1981-1994 VB denotes differentiate
T3252 1995-1998 CC denotes and
T3253 1999-2007 VB denotes activate
T3254 2008-2011 DT denotes the
T3255 2012-2021 JJ denotes dendritic
T3256 2022-2027 NN denotes cells
T3257 2028-2029 -LRB- denotes [
T3258 2029-2033 CD denotes 8-10
T3259 2033-2034 -RRB- denotes ]
T3260 2036-2042 NN denotes Levels
T3261 2043-2045 IN denotes of
T3262 2046-2051 NN denotes IL-17
T3263 2052-2054 IN denotes in
T3264 2055-2063 JJ denotes synovial
T3265 2064-2070 NN denotes fluids
T3266 2071-2075 VB denotes were
T3267 2076-2089 RB denotes significantly
T3268 2090-2096 JJ denotes higher
T3269 2097-2099 IN denotes in
T3270 2100-2108 NN denotes patients
T3271 2109-2113 IN denotes with
T3272 2114-2116 NN denotes RA
T3273 2117-2121 IN denotes than
T3274 2122-2124 IN denotes in
T3275 2125-2133 NN denotes patients
T3276 2134-2138 IN denotes with
T3277 2139-2153 NN denotes osteoarthritis
T3278 2154-2155 -LRB- denotes (
T3279 2155-2157 NN denotes OA
T3280 2157-2158 -RRB- denotes )
T3281 2158-2159 -COMMA- denotes ,
T3282 2160-2163 CC denotes and
T3283 2164-2166 PRP denotes it
T3284 2167-2170 VB denotes was
T3285 2171-2179 VB denotes produced
T3286 2180-2182 IN denotes by
T3287 2183-2187 JJ denotes CD4+
T3288 2188-2189 NN denotes T
T3289 2190-2195 NN denotes cells
T3290 2196-2198 IN denotes in
T3291 2199-2202 DT denotes the
T3292 2203-2211 NN denotes synovium
T3293 2212-2213 -LRB- denotes [
T3294 2213-2218 CD denotes 11,12
T3295 2218-2219 -RRB- denotes ]
T3296 2221-2226 NN denotes IL-15
T3297 2226-2227 -COMMA- denotes ,
T3298 2228-2236 VB denotes secreted
T3299 2237-2241 IN denotes from
T3300 2242-2251 VB denotes activated
T3301 2252-2263 NN denotes macrophages
T3302 2263-2264 -COMMA- denotes ,
T3303 2265-2268 VB denotes has
T3304 2269-2273 VB denotes been
T3305 2274-2282 VB denotes reported
T3306 2283-2285 TO denotes to
T3307 2286-2288 VB denotes be
T3308 2289-2291 DT denotes an
T3309 2292-2301 JJ denotes important
T3310 2302-2309 NN denotes trigger
T3311 2310-2312 IN denotes of
T3312 2313-2318 NN denotes IL-17
T3313 2319-2329 NN denotes production
T3314 2330-2332 IN denotes in
T3315 2333-2335 NN denotes RA
T3316 2336-2346 JJ denotes peripheral
T3317 2347-2352 NN denotes blood
T3318 2353-2364 JJ denotes mononuclear
T3319 2365-2370 NN denotes cells
T3320 2371-2372 -LRB- denotes (
T3321 2372-2376 NN denotes PBMC
T3322 2376-2377 -RRB- denotes )
T3323 2378-2380 IN denotes by
T3324 2381-2393 NN denotes cyclosporine
T3325 2394-2397 CC denotes and
T3326 2398-2405 NN denotes steroid
T3327 2406-2415 JJ denotes sensitive
T3328 2416-2424 NN denotes pathways
T3329 2425-2426 -LRB- denotes [
T3330 2426-2428 CD denotes 13
T3331 2428-2429 -RRB- denotes ]
T3332 2431-2439 RB denotes Recently
T3333 2439-2440 -COMMA- denotes ,
T3334 2441-2447 NNP denotes Happel
T3335 2448-2451 CC denotes and
T3336 2452-2462 NN denotes colleagues
T3337 2463-2467 RB denotes also
T3338 2468-2474 VB denotes showed
T3339 2475-2479 IN denotes that
T3340 2480-2485 NN denotes IL-23
T3341 2486-2491 MD denotes could
T3342 2492-2494 VB denotes be
T3343 2495-2497 DT denotes an
T3344 2498-2507 JJ denotes efficient
T3345 2508-2515 NN denotes trigger
T3346 2516-2518 IN denotes of
T3347 2519-2524 NN denotes IL-17
T3348 2525-2535 NN denotes production
T3349 2536-2540 IN denotes from
T3350 2541-2545 CC denotes both
T3351 2546-2550 JJ denotes CD4+
T3352 2551-2554 CC denotes and
T3353 2555-2559 JJ denotes CD8+
T3354 2560-2561 NN denotes T
T3355 2562-2567 NN denotes cells
T3356 2568-2569 -LRB- denotes [
T3357 2569-2571 CD denotes 14
T3358 2571-2572 -RRB- denotes ]
T3359 2574-2582 IN denotes Although
T3360 2583-2586 DT denotes the
T3361 2587-2599 NN denotes contribution
T3362 2600-2602 IN denotes of
T3363 2603-2608 NN denotes IL-17
T3364 2609-2611 IN denotes in
T3365 2612-2617 JJ denotes joint
T3366 2618-2630 NN denotes inflammation
T3367 2631-2633 IN denotes in
T3368 2634-2636 NN denotes RA
T3369 2637-2640 VB denotes has
T3370 2641-2645 VB denotes been
T3371 2646-2656 VB denotes documented
T3372 2657-2659 IN denotes in
T3373 2660-2667 JJ denotes earlier
T3374 2668-2675 NN denotes studies
T3375 2676-2677 -LRB- denotes [
T3376 2677-2685 CD denotes 12,15,16
T3377 2685-2686 -RRB- denotes ]
T3378 2686-2687 -COMMA- denotes ,
T3379 2688-2691 DT denotes the
T3380 2692-2705 JJ denotes intracellular
T3381 2706-2712 NN denotes signal
T3382 2713-2725 NN denotes transduction
T3383 2726-2733 NN denotes pathway
T3384 2734-2737 IN denotes for
T3385 2738-2743 NN denotes IL-17
T3386 2744-2754 NN denotes production
T3387 2755-2762 VB denotes remains
T3388 2763-2772 JJ denotes uncertain
T3389 2774-2776 IN denotes In
T3390 2777-2780 DT denotes the
T3391 2781-2788 JJ denotes present
T3392 2789-2794 NN denotes study
T3393 2795-2797 PRP denotes we
T3394 2798-2802 VB denotes used
T3395 2803-2810 JJ denotes various
T3396 2811-2818 NN denotes stimuli
T3397 2819-2821 TO denotes to
T3398 2822-2833 VB denotes investigate
T3399 2834-2839 NN denotes IL-17
T3400 2840-2850 NN denotes production
T3401 2851-2853 IN denotes in
T3402 2854-2858 NN denotes PBMC
T3403 2859-2861 IN denotes of
T3404 2862-2870 NN denotes patients
T3405 2871-2875 IN denotes with
T3406 2876-2878 NN denotes RA
T3407 2879-2882 CC denotes and
T3408 2883-2886 PRP-DOLLAR- denotes its
T3409 2887-2896 NN denotes signaling
T3410 2897-2909 NN denotes transduction
T3411 2910-2917 NN denotes pathway
T3412 2919-2921 PRP denotes We
T3413 2922-2927 VB denotes found
T3414 2928-2932 IN denotes that
T3415 2933-2936 DT denotes the
T3416 2937-2950 JJ denotes intracellular
T3417 2951-2960 NN denotes signaling
T3418 2961-2968 NN denotes pathway
T3419 2969-2978 VB denotes involving
T3420 2979-2995 NN denotes phosphoinositide
T3421 2996-3004 NN denotes 3-kinase
T3422 3005-3006 -LRB- denotes (
T3423 3006-3010 NN denotes PI3K
T3424 3010-3011 -RRB- denotes )
T3425 3011-3015 NN denotes /Akt
T3426 3016-3019 CC denotes and
T3427 3020-3025 NN denotes NF-κB
T3428 3026-3031 MD denotes might
T3429 3032-3034 VB denotes be
T3430 3035-3043 VB denotes involved
T3431 3044-3046 IN denotes in
T3432 3047-3050 DT denotes the
T3433 3051-3065 NN denotes overproduction
T3434 3066-3068 IN denotes of
T3435 3069-3072 DT denotes the
T3436 3073-3076 JJ denotes key
T3437 3077-3089 JJ denotes inflammatory
T3438 3090-3098 NN denotes cytokine
T3439 3099-3104 NN denotes IL-17
T3440 3105-3107 IN denotes in
T3441 3108-3110 NN denotes RA
T3442 3112-3117 DT denotes These
T3443 3118-3125 NN denotes results
T3444 3126-3131 MD denotes might
T3445 3132-3139 VB denotes provide
T3446 3140-3143 JJ denotes new
T3447 3144-3152 NN denotes insights
T3448 3153-3157 IN denotes into
T3449 3158-3161 DT denotes the
T3450 3162-3174 NN denotes pathogenesis
T3451 3175-3177 IN denotes of
T3452 3178-3180 NN denotes RA
T3453 3181-3184 CC denotes and
T3454 3185-3191 JJ denotes future
T3455 3192-3202 NN denotes directions
T3456 3203-3206 IN denotes for
T3457 3207-3210 JJ denotes new
T3458 3211-3222 JJ denotes therapeutic
T3459 3223-3233 NN denotes strategies
T3460 3234-3236 IN denotes in
T3461 3237-3239 NN denotes RA
R1151 T2894 T2893 arg1Of arthritis,Rheumatoid
R1152 T2894 T2895 arg1Of arthritis,(
R1153 T2894 T2898 arg1Of arthritis,is
R1154 T2894 T2899 arg2Of arthritis,characterized
R1155 T2896 T2895 arg2Of RA,(
R1156 T2897 T2895 arg3Of ),(
R1157 T2899 T2898 arg2Of characterized,is
R1158 T2901 T2899 arg1Of infiltrations,characterized
R1159 T2901 T2900 arg2Of infiltrations,by
R1160 T2901 T2902 arg1Of infiltrations,of
R1161 T2903 T2904 arg1Of macrophages,and
R1162 T2904 T2907 arg1Of and,into
R1163 T2904 T2911 arg1Of and,and
R1164 T2906 T2904 arg2Of cells,and
R1165 T2906 T2905 arg1Of cells,T
R1166 T2909 T2907 arg2Of joint,into
R1167 T2909 T2908 arg1Of joint,the
R1168 T2911 T2902 arg2Of and,of
R1169 T2911 T2910 arg1Of and,","
R1170 T2913 T2911 arg2Of hyperplasia,and
R1171 T2913 T2912 arg1Of hyperplasia,synovial
R1172 T2915 T2914 arg1Of cytokines,Proinflammatory
R1173 T2915 T2916 arg2Of cytokines,released
R1174 T2915 T2920 arg1Of cytokines,are
R1175 T2915 T2921 arg2Of cytokines,known
R1176 T2915 T2923 arg1Of cytokines,be
R1177 T2915 T2924 arg1Of cytokines,important
R1178 T2916 T2917 arg1Of released,from
R1179 T2919 T2917 arg2Of cells,from
R1180 T2919 T2918 arg1Of cells,these
R1181 T2921 T2920 arg2Of known,are
R1182 T2921 T2932 arg1Of known,[
R1183 T2923 T2921 arg3Of be,known
R1184 T2923 T2922 arg1Of be,to
R1185 T2924 T2923 arg2Of important,be
R1186 T2924 T2925 arg1Of important,in
R1187 T2927 T2925 arg2Of destruction,in
R1188 T2927 T2926 arg1Of destruction,the
R1189 T2927 T2928 arg1Of destruction,of
R1190 T2927 T2930 arg1Of destruction,in
R1191 T2929 T2928 arg2Of joints,of
R1192 T2931 T2930 arg2Of RA,in
R1193 T2933 T2932 arg2Of 1,[
R1194 T2934 T2932 arg3Of ],[
R1195 T2938 T2935 arg1Of benefits,The
R1196 T2938 T2936 arg1Of benefits,favorable
R1197 T2938 T2937 arg1Of benefits,clinical
R1198 T2938 T2939 arg2Of benefits,obtained
R1199 T2938 T2950 arg1Of benefits,)
R1200 T2938 T2951 arg1Of benefits,and
R1201 T2939 T2940 arg1Of obtained,with
R1202 T2941 T2940 arg2Of inhibitors,with
R1203 T2941 T2942 arg1Of inhibitors,of
R1204 T2945 T2943 arg1Of factor,tumor
R1205 T2945 T2944 arg1Of factor,necrosis
R1206 T2945 T2946 arg1Of factor,(
R1207 T2947 T2946 arg2Of TNF,(
R1208 T2948 T2946 arg3Of ),(
R1209 T2949 T2942 arg2Of -α,of
R1210 T2949 T2945 arg1Of -α,factor
R1211 T2951 T2957 arg1Of and,suggest
R1212 T2952 T2951 arg2Of interleukin,and
R1213 T2952 T2953 arg1Of interleukin,(
R1214 T2952 T2956 arg1Of interleukin,-1
R1215 T2954 T2953 arg2Of IL,(
R1216 T2955 T2953 arg3Of ),(
R1217 T2960 T2959 arg1Of blockade,the
R1218 T2960 T2961 arg1Of blockade,of
R1219 T2960 T2965 arg1Of blockade,has
R1220 T2960 T2966 arg1Of blockade,been
R1221 T2964 T2961 arg2Of cytokines,of
R1222 T2964 T2962 arg1Of cytokines,key
R1223 T2964 T2963 arg1Of cytokines,inflammatory
R1224 T2966 T2957 arg2Of been,suggest
R1225 T2966 T2958 arg1Of been,that
R1226 T2966 T2965 arg2Of been,has
R1227 T2966 T2970 arg1Of been,in
R1228 T2966 T2977 arg1Of been,[
R1229 T2969 T2966 arg2Of issue,been
R1230 T2969 T2967 arg1Of issue,the
R1231 T2969 T2968 arg1Of issue,important
R1232 T2972 T2970 arg2Of development,in
R1233 T2972 T2971 arg1Of development,the
R1234 T2972 T2973 arg1Of development,of
R1235 T2976 T2973 arg2Of applications,of
R1236 T2976 T2974 arg1Of applications,new
R1237 T2976 T2975 arg1Of applications,therapeutic
R1238 T2978 T2977 arg2Of 2,[
R1239 T2979 T2977 arg3Of ],[
R1240 T2981 T2980 arg1Of little,A
R1241 T2983 T2982 arg1Of a,over
R1242 T2984 T2983 arg1Of decade,a
R1243 T2985 T2981 arg1Of ago,little
R1244 T2985 T2984 arg1Of ago,decade
R1245 T2988 T2987 arg1Of primacy,the
R1246 T2988 T2989 arg1Of primacy,of
R1247 T2988 T2992 arg1Of primacy,in
R1248 T2988 T2999 arg1Of primacy,as
R1249 T2988 T3001 arg1Of primacy,was
R1250 T2988 T3002 arg1Of primacy,undisputed
R1251 T2991 T2989 arg2Of cells,of
R1252 T2991 T2990 arg1Of cells,T
R1253 T2994 T2992 arg2Of pathogenesis,in
R1254 T2994 T2993 arg1Of pathogenesis,the
R1255 T2994 T2995 arg1Of pathogenesis,of
R1256 T2997 T2995 arg2Of disease,of
R1257 T2997 T2996 arg1Of disease,autoimmune
R1258 T2999 T2998 arg1Of as,such
R1259 T3000 T2999 arg2Of RA,as
R1260 T3001 T2985 arg1Of was,ago
R1261 T3001 T2986 arg1Of was,","
R1262 T3001 T3003 arg1Of was,because
R1263 T3002 T3001 arg2Of undisputed,was
R1264 T3004 T3005 arg1Of they,are
R1265 T3005 T3003 arg2Of are,because
R1266 T3009 T3005 arg2Of population,are
R1267 T3009 T3006 arg1Of population,the
R1268 T3009 T3007 arg1Of population,largest
R1269 T3009 T3008 arg1Of population,cell
R1270 T3009 T3010 arg1Of population,infiltrating
R1271 T3012 T3010 arg2Of synovium,infiltrating
R1272 T3012 T3011 arg1Of synovium,the
R1273 T3016 T3015 arg1Of series,a
R1274 T3016 T3017 arg1Of series,of
R1275 T3016 T3019 arg1Of series,demonstrated
R1276 T3018 T3017 arg2Of studies,of
R1277 T3019 T3013 arg1Of demonstrated,However
R1278 T3019 T3014 arg1Of demonstrated,","
R1279 T3019 T3035 arg1Of demonstrated,","
R1280 T3019 T3036 arg1Of demonstrated,whereas
R1281 T3020 T3019 arg2Of paucity,demonstrated
R1282 T3020 T3021 arg1Of paucity,of
R1283 T3024 T3021 arg2Of cytokines,of
R1284 T3024 T3022 arg1Of cytokines,T
R1285 T3024 T3023 arg1Of cytokines,cell-derived
R1286 T3024 T3026 arg1Of cytokines,as
R1287 T3026 T3025 arg1Of as,such
R1288 T3027 T3028 arg1Of IL-2,and
R1289 T3028 T3026 arg2Of and,as
R1290 T3028 T3030 arg1Of and,in
R1291 T3029 T3028 arg2Of interferon-γ,and
R1292 T3032 T3030 arg2Of joints,in
R1293 T3032 T3031 arg1Of joints,the
R1294 T3032 T3033 arg1Of joints,of
R1295 T3034 T3033 arg2Of RA,of
R1296 T3037 T3038 arg1Of macrophage,and
R1297 T3039 T3038 arg2Of fibroblast,and
R1298 T3040 T3037 arg1Of cytokines,macrophage
R1299 T3040 T3039 arg1Of cytokines,fibroblast
R1300 T3040 T3041 arg1Of cytokines,including
R1301 T3040 T3051 arg1Of cytokines,were
R1302 T3040 T3052 arg1Of cytokines,abundant
R1303 T3042 T3043 arg1Of IL-1,","
R1304 T3043 T3045 arg1Of ",",","
R1305 T3044 T3043 arg2Of IL-6,","
R1306 T3045 T3047 arg1Of ",",","
R1307 T3046 T3045 arg2Of IL-15,","
R1308 T3047 T3049 arg1Of ",",and
R1309 T3048 T3047 arg2Of IL-18,","
R1310 T3049 T3041 arg2Of and,including
R1311 T3050 T3049 arg2Of TNF-α,and
R1312 T3051 T3036 arg2Of were,whereas
R1313 T3051 T3053 arg1Of were,in
R1314 T3052 T3051 arg2Of abundant,were
R1315 T3055 T3053 arg2Of synovium,in
R1316 T3055 T3054 arg1Of synovium,rheumatoid
R1317 T3057 T3056 arg1Of paradox,This
R1318 T3057 T3058 arg1Of paradox,has
R1319 T3057 T3059 arg1Of paradox,questioned
R1320 T3059 T3058 arg2Of questioned,has
R1321 T3061 T3059 arg2Of role,questioned
R1322 T3061 T3060 arg1Of role,the
R1323 T3061 T3062 arg1Of role,of
R1324 T3061 T3065 arg1Of role,in
R1325 T3064 T3062 arg2Of cells,of
R1326 T3064 T3063 arg1Of cells,T
R1327 T3067 T3065 arg2Of pathogenesis,in
R1328 T3067 T3066 arg1Of pathogenesis,the
R1329 T3067 T3068 arg1Of pathogenesis,of
R1330 T3069 T3068 arg2Of RA,of
R1331 T3069 T3070 arg1Of RA,[
R1332 T3071 T3070 arg2Of 3,[
R1333 T3072 T3070 arg3Of ],[
R1334 T3074 T3075 arg1Of we,have
R1335 T3074 T3077 arg1Of we,demonstrated
R1336 T3077 T3073 arg2Of demonstrated,Because
R1337 T3077 T3075 arg2Of demonstrated,have
R1338 T3077 T3076 arg1Of demonstrated,already
R1339 T3077 T3105 arg1Of demonstrated,in
R1340 T3080 T3078 arg1Of proliferation,the
R1341 T3080 T3079 arg2Of proliferation,enhanced
R1342 T3080 T3081 arg1Of proliferation,of
R1343 T3080 T3086 arg1Of proliferation,","
R1344 T3080 T3088 arg1Of proliferation,to
R1345 T3080 T3093 arg1Of proliferation,and
R1346 T3085 T3081 arg2Of cells,of
R1347 T3085 T3082 arg1Of cells,antigen
R1348 T3085 T3083 arg1Of cells,specific
R1349 T3085 T3084 arg1Of cells,T
R1350 T3088 T3087 arg1Of to,especially
R1351 T3091 T3088 arg2Of collagen,to
R1352 T3091 T3089 arg1Of collagen,type
R1353 T3091 T3090 arg1Of collagen,II
R1354 T3093 T3077 arg2Of and,demonstrated
R1355 T3093 T3092 arg1Of and,","
R1356 T3095 T3093 arg2Of skewing,and
R1357 T3095 T3094 arg1Of skewing,the
R1358 T3095 T3096 arg1Of skewing,of
R1359 T3102 T3101 arg2Of Th1,(
R1360 T3103 T3101 arg3Of ),(
R1361 T3104 T3096 arg2Of cytokines,of
R1362 T3104 T3097 arg1Of cytokines,T
R1363 T3104 T3098 arg1Of cytokines,helper
R1364 T3104 T3099 arg1Of cytokines,type
R1365 T3104 T3100 arg1Of cytokines,1
R1366 T3104 T3101 arg1Of cytokines,(
R1367 T3106 T3105 arg2Of RA,in
R1368 T3106 T3107 arg1Of RA,[
R1369 T3108 T3107 arg2Of 4,[
R1370 T3109 T3107 arg3Of ],[
R1371 T3112 T3111 arg1Of role,the
R1372 T3112 T3113 arg1Of role,of
R1373 T3112 T3116 arg1Of role,needs
R1374 T3112 T3118 arg1Of role,be
R1375 T3112 T3119 arg2Of role,elucidated
R1376 T3115 T3113 arg2Of cells,of
R1377 T3115 T3114 arg1Of cells,T
R1378 T3116 T3073 arg1Of needs,Because
R1379 T3116 T3110 arg1Of needs,","
R1380 T3119 T3116 arg2Of elucidated,needs
R1381 T3119 T3117 arg1Of elucidated,to
R1382 T3119 T3118 arg2Of elucidated,be
R1383 T3119 T3120 arg1Of elucidated,in
R1384 T3122 T3120 arg2Of aspects,in
R1385 T3122 T3121 arg1Of aspects,different
R1386 T3123 T3124 arg1Of IL-17,is
R1387 T3125 T3124 arg2Of one,is
R1388 T3125 T3126 arg1Of one,of
R1389 T3129 T3126 arg2Of cytokines,of
R1390 T3129 T3127 arg1Of cytokines,the
R1391 T3129 T3128 arg1Of cytokines,inflammatory
R1392 T3129 T3130 arg2Of cytokines,secreted
R1393 T3135 T3130 arg1Of cells,secreted
R1394 T3135 T3131 arg1Of cells,mainly
R1395 T3135 T3132 arg2Of cells,by
R1396 T3135 T3133 arg2Of cells,activated
R1397 T3135 T3134 arg1Of cells,T
R1398 T3135 T3136 arg1Of cells,","
R1399 T3135 T3137 arg1Of cells,which
R1400 T3135 T3138 arg1Of cells,can
R1401 T3135 T3139 arg1Of cells,induce
R1402 T3139 T3138 arg2Of induce,can
R1403 T3139 T3145 arg1Of induce,[
R1404 T3140 T3141 arg1Of IL-6,and
R1405 T3141 T3139 arg2Of and,induce
R1406 T3141 T3143 arg1Of and,by
R1407 T3142 T3141 arg2Of IL-8,and
R1408 T3144 T3143 arg2Of fibroblasts,by
R1409 T3146 T3145 arg2Of 5,[
R1410 T3147 T3145 arg3Of ],[
R1411 T3149 T3148 arg1Of cytokine,This
R1412 T3149 T3150 arg1Of cytokine,is
R1413 T3149 T3151 arg1Of cytokine,of
R1414 T3150 T3153 arg1Of is,for
R1415 T3150 T3157 arg1Of is,:
R1416 T3151 T3150 arg2Of of,is
R1417 T3152 T3151 arg2Of interest,of
R1418 T3156 T3153 arg2Of reasons,for
R1419 T3156 T3154 arg1Of reasons,two
R1420 T3156 T3155 arg1Of reasons,major
R1421 T3158 T3159 arg1Of first,","
R1422 T3160 T3159 arg2Of similarly,","
R1423 T3160 T3161 arg1Of similarly,to
R1424 T3162 T3163 arg1Of TNF-α,and
R1425 T3163 T3161 arg2Of and,to
R1426 T3164 T3163 arg2Of IL-1,and
R1427 T3166 T3167 arg1Of IL-17,has
R1428 T3167 T3157 arg2Of has,:
R1429 T3167 T3158 arg1Of has,first
R1430 T3167 T3160 arg1Of has,similarly
R1431 T3167 T3165 arg1Of has,","
R1432 T3167 T3170 arg1Of has,;
R1433 T3169 T3167 arg2Of properties,has
R1434 T3169 T3168 arg1Of properties,proinflammatory
R1435 T3173 T3174 arg1Of it,is
R1436 T3173 T3175 arg2Of it,produced
R1437 T3175 T3170 arg2Of produced,;
R1438 T3175 T3171 arg1Of produced,second
R1439 T3175 T3172 arg1Of produced,","
R1440 T3175 T3174 arg2Of produced,is
R1441 T3175 T3179 arg1Of produced,[
R1442 T3178 T3175 arg1Of cells,produced
R1443 T3178 T3176 arg2Of cells,by
R1444 T3178 T3177 arg1Of cells,T
R1445 T3180 T3179 arg2Of 6,[
R1446 T3181 T3179 arg3Of ],[
R1447 T3183 T3182 arg1Of observations,Recent
R1448 T3183 T3184 arg1Of observations,demonstrated
R1449 T3186 T3187 arg1Of IL-17,can
R1450 T3186 T3189 arg1Of IL-17,activate
R1451 T3189 T3184 arg2Of activate,demonstrated
R1452 T3189 T3185 arg1Of activate,that
R1453 T3189 T3187 arg2Of activate,can
R1454 T3189 T3188 arg1Of activate,also
R1455 T3189 T3193 arg1Of activate,by
R1456 T3192 T3189 arg2Of resorption,activate
R1457 T3192 T3190 arg1Of resorption,osteoclastic
R1458 T3192 T3191 arg1Of resorption,bone
R1459 T3195 T3193 arg2Of induction,by
R1460 T3195 T3194 arg1Of induction,the
R1461 T3195 T3196 arg1Of induction,of
R1462 T3195 T3198 arg1Of induction,(
R1463 T3195 T3210 arg1Of induction,","
R1464 T3195 T3211 arg1Of induction,which
R1465 T3195 T3212 arg1Of induction,is
R1466 T3195 T3213 arg2Of induction,involved
R1467 T3197 T3196 arg2Of RANKL,of
R1468 T3200 T3198 arg2Of activator,(
R1469 T3200 T3199 arg1Of activator,receptor
R1470 T3200 T3201 arg1Of activator,of
R1471 T3206 T3205 arg2Of NF-κB,[
R1472 T3207 T3205 arg3Of ],[
R1473 T3208 T3201 arg2Of ligand,of
R1474 T3208 T3202 arg1Of ligand,nuclear
R1475 T3208 T3203 arg1Of ligand,factor
R1476 T3208 T3204 arg1Of ligand,κB
R1477 T3208 T3205 arg1Of ligand,[
R1478 T3209 T3198 arg3Of ),(
R1479 T3213 T3212 arg2Of involved,is
R1480 T3213 T3214 arg1Of involved,in
R1481 T3216 T3214 arg2Of erosion,in
R1482 T3216 T3215 arg1Of erosion,bony
R1483 T3216 T3217 arg1Of erosion,in
R1484 T3218 T3217 arg2Of RA,in
R1485 T3218 T3219 arg1Of RA,[
R1486 T3220 T3219 arg2Of 7,[
R1487 T3221 T3219 arg3Of ],[
R1488 T3222 T3224 arg1Of It,stimulates
R1489 T3222 T3247 arg1Of It,has
R1490 T3224 T3246 arg1Of stimulates,and
R1491 T3226 T3224 arg2Of production,stimulates
R1492 T3226 T3225 arg1Of production,the
R1493 T3226 T3227 arg1Of production,of
R1494 T3226 T3237 arg1Of production,of
R1495 T3227 T3236 arg1Of of,and
R1496 T3228 T3229 arg1Of IL-6,and
R1497 T3229 T3227 arg2Of and,of
R1498 T3229 T3233 arg1Of and,by
R1499 T3232 T3229 arg2Of factor,and
R1500 T3232 T3230 arg1Of factor,leukemia
R1501 T3232 T3231 arg1Of factor,inhibitory
R1502 T3234 T3233 arg2Of synoviocytes,by
R1503 T3236 T3235 arg1Of and,","
R1504 T3237 T3236 arg2Of of,and
R1505 T3239 T3238 arg1Of E2,prostaglandin
R1506 T3239 T3240 arg1Of E2,and
R1507 T3240 T3237 arg2Of and,of
R1508 T3240 T3243 arg1Of and,by
R1509 T3242 T3240 arg2Of oxide,and
R1510 T3242 T3241 arg1Of oxide,nitric
R1511 T3244 T3243 arg2Of chondrocytes,by
R1512 T3246 T3223 arg1Of and,also
R1513 T3246 T3245 arg1Of and,","
R1514 T3247 T3246 arg2Of has,and
R1515 T3249 T3247 arg2Of ability,has
R1516 T3249 T3248 arg1Of ability,the
R1517 T3249 T3250 modOf ability,to
R1518 T3251 T3252 arg1Of differentiate,and
R1519 T3252 T3250 arg1Of and,to
R1520 T3252 T3257 arg1Of and,[
R1521 T3253 T3252 arg2Of activate,and
R1522 T3256 T3251 arg2Of cells,differentiate
R1523 T3256 T3253 arg2Of cells,activate
R1524 T3256 T3254 arg1Of cells,the
R1525 T3256 T3255 arg1Of cells,dendritic
R1526 T3258 T3257 arg2Of 8-10,[
R1527 T3259 T3257 arg3Of ],[
R1528 T3260 T3261 arg1Of Levels,of
R1529 T3260 T3263 arg1Of Levels,in
R1530 T3260 T3266 arg1Of Levels,were
R1531 T3260 T3268 arg1Of Levels,higher
R1532 T3262 T3261 arg2Of IL-17,of
R1533 T3265 T3263 arg2Of fluids,in
R1534 T3265 T3264 arg1Of fluids,synovial
R1535 T3266 T3282 arg1Of were,and
R1536 T3268 T3266 arg2Of higher,were
R1537 T3268 T3267 arg1Of higher,significantly
R1538 T3268 T3269 arg1Of higher,in
R1539 T3268 T3273 arg1Of higher,than
R1540 T3270 T3269 arg2Of patients,in
R1541 T3270 T3271 arg1Of patients,with
R1542 T3272 T3271 arg2Of RA,with
R1543 T3274 T3273 arg2Of in,than
R1544 T3275 T3274 arg2Of patients,in
R1545 T3275 T3276 arg1Of patients,with
R1546 T3277 T3276 arg2Of osteoarthritis,with
R1547 T3277 T3278 arg1Of osteoarthritis,(
R1548 T3279 T3278 arg2Of OA,(
R1549 T3280 T3278 arg3Of ),(
R1550 T3282 T3281 arg1Of and,","
R1551 T3282 T3293 arg1Of and,[
R1552 T3283 T3284 arg1Of it,was
R1553 T3283 T3285 arg2Of it,produced
R1554 T3285 T3282 arg2Of produced,and
R1555 T3285 T3284 arg2Of produced,was
R1556 T3285 T3290 arg1Of produced,in
R1557 T3289 T3285 arg1Of cells,produced
R1558 T3289 T3286 arg2Of cells,by
R1559 T3289 T3287 arg1Of cells,CD4+
R1560 T3289 T3288 arg1Of cells,T
R1561 T3292 T3290 arg2Of synovium,in
R1562 T3292 T3291 arg1Of synovium,the
R1563 T3294 T3293 arg2Of "11,12",[
R1564 T3295 T3293 arg3Of ],[
R1565 T3296 T3297 arg1Of IL-15,","
R1566 T3296 T3298 arg2Of IL-15,secreted
R1567 T3296 T3303 arg1Of IL-15,has
R1568 T3296 T3304 arg1Of IL-15,been
R1569 T3296 T3305 arg2Of IL-15,reported
R1570 T3296 T3307 arg1Of IL-15,be
R1571 T3298 T3299 arg1Of secreted,from
R1572 T3301 T3299 arg2Of macrophages,from
R1573 T3301 T3300 arg2Of macrophages,activated
R1574 T3305 T3302 arg1Of reported,","
R1575 T3305 T3303 arg2Of reported,has
R1576 T3305 T3304 arg2Of reported,been
R1577 T3307 T3305 arg3Of be,reported
R1578 T3307 T3306 arg1Of be,to
R1579 T3307 T3314 arg1Of be,in
R1580 T3307 T3323 arg1Of be,by
R1581 T3307 T3329 arg1Of be,[
R1582 T3310 T3307 arg2Of trigger,be
R1583 T3310 T3308 arg1Of trigger,an
R1584 T3310 T3309 arg1Of trigger,important
R1585 T3310 T3311 arg1Of trigger,of
R1586 T3313 T3311 arg2Of production,of
R1587 T3313 T3312 arg1Of production,IL-17
R1588 T3319 T3314 arg2Of cells,in
R1589 T3319 T3315 arg1Of cells,RA
R1590 T3319 T3316 arg1Of cells,peripheral
R1591 T3319 T3317 arg1Of cells,blood
R1592 T3319 T3318 arg1Of cells,mononuclear
R1593 T3319 T3320 arg1Of cells,(
R1594 T3321 T3320 arg2Of PBMC,(
R1595 T3322 T3320 arg3Of ),(
R1596 T3324 T3325 arg1Of cyclosporine,and
R1597 T3325 T3323 arg2Of and,by
R1598 T3328 T3325 arg2Of pathways,and
R1599 T3328 T3326 arg1Of pathways,steroid
R1600 T3328 T3327 arg1Of pathways,sensitive
R1601 T3330 T3329 arg2Of 13,[
R1602 T3331 T3329 arg3Of ],[
R1603 T3334 T3335 arg1Of Happel,and
R1604 T3335 T3338 arg1Of and,showed
R1605 T3336 T3335 arg2Of colleagues,and
R1606 T3338 T3332 arg1Of showed,Recently
R1607 T3338 T3333 arg1Of showed,","
R1608 T3338 T3337 arg1Of showed,also
R1609 T3340 T3341 arg1Of IL-23,could
R1610 T3340 T3342 arg1Of IL-23,be
R1611 T3342 T3338 arg2Of be,showed
R1612 T3342 T3339 arg1Of be,that
R1613 T3342 T3341 arg2Of be,could
R1614 T3345 T3342 arg2Of trigger,be
R1615 T3345 T3343 arg1Of trigger,an
R1616 T3345 T3344 arg1Of trigger,efficient
R1617 T3345 T3346 arg1Of trigger,of
R1618 T3345 T3349 arg1Of trigger,from
R1619 T3348 T3346 arg2Of production,of
R1620 T3348 T3347 arg1Of production,IL-17
R1621 T3351 T3352 arg1Of CD4+,and
R1622 T3353 T3352 arg2Of CD8+,and
R1623 T3355 T3349 arg2Of cells,from
R1624 T3355 T3350 arg1Of cells,both
R1625 T3355 T3351 arg1Of cells,CD4+
R1626 T3355 T3353 arg1Of cells,CD8+
R1627 T3355 T3354 arg1Of cells,T
R1628 T3355 T3356 arg1Of cells,[
R1629 T3357 T3356 arg2Of 14,[
R1630 T3358 T3356 arg3Of ],[
R1631 T3361 T3360 arg1Of contribution,the
R1632 T3361 T3362 arg1Of contribution,of
R1633 T3361 T3364 arg1Of contribution,in
R1634 T3361 T3369 arg1Of contribution,has
R1635 T3361 T3370 arg1Of contribution,been
R1636 T3361 T3371 arg2Of contribution,documented
R1637 T3363 T3362 arg2Of IL-17,of
R1638 T3366 T3364 arg2Of inflammation,in
R1639 T3366 T3365 arg1Of inflammation,joint
R1640 T3366 T3367 arg1Of inflammation,in
R1641 T3368 T3367 arg2Of RA,in
R1642 T3371 T3359 arg2Of documented,Although
R1643 T3371 T3369 arg2Of documented,has
R1644 T3371 T3370 arg2Of documented,been
R1645 T3371 T3372 arg1Of documented,in
R1646 T3374 T3372 arg2Of studies,in
R1647 T3374 T3373 arg1Of studies,earlier
R1648 T3374 T3375 arg1Of studies,[
R1649 T3376 T3375 arg2Of "12,15,16",[
R1650 T3377 T3375 arg3Of ],[
R1651 T3383 T3379 arg1Of pathway,the
R1652 T3383 T3380 arg1Of pathway,intracellular
R1653 T3383 T3381 arg1Of pathway,signal
R1654 T3383 T3382 arg1Of pathway,transduction
R1655 T3383 T3384 arg1Of pathway,for
R1656 T3383 T3387 arg1Of pathway,remains
R1657 T3383 T3388 arg1Of pathway,uncertain
R1658 T3386 T3384 arg2Of production,for
R1659 T3386 T3385 arg1Of production,IL-17
R1660 T3387 T3359 arg1Of remains,Although
R1661 T3387 T3378 arg1Of remains,","
R1662 T3388 T3387 arg2Of uncertain,remains
R1663 T3392 T3389 arg2Of study,In
R1664 T3392 T3390 arg1Of study,the
R1665 T3392 T3391 arg1Of study,present
R1666 T3393 T3394 arg1Of we,used
R1667 T3393 T3398 arg1Of we,investigate
R1668 T3394 T3389 arg1Of used,In
R1669 T3396 T3394 arg2Of stimuli,used
R1670 T3396 T3395 arg1Of stimuli,various
R1671 T3398 T3394 arg3Of investigate,used
R1672 T3398 T3397 arg1Of investigate,to
R1673 T3400 T3398 arg2Of production,investigate
R1674 T3400 T3399 arg1Of production,IL-17
R1675 T3400 T3401 arg1Of production,in
R1676 T3402 T3403 arg1Of PBMC,of
R1677 T3402 T3407 arg1Of PBMC,and
R1678 T3404 T3403 arg2Of patients,of
R1679 T3404 T3405 arg1Of patients,with
R1680 T3406 T3405 arg2Of RA,with
R1681 T3407 T3401 arg2Of and,in
R1682 T3411 T3407 arg2Of pathway,and
R1683 T3411 T3408 arg1Of pathway,its
R1684 T3411 T3409 arg1Of pathway,signaling
R1685 T3411 T3410 arg1Of pathway,transduction
R1686 T3412 T3413 arg1Of We,found
R1687 T3418 T3415 arg1Of pathway,the
R1688 T3418 T3416 arg1Of pathway,intracellular
R1689 T3418 T3417 arg1Of pathway,signaling
R1690 T3418 T3419 arg1Of pathway,involving
R1691 T3418 T3428 arg1Of pathway,might
R1692 T3418 T3429 arg1Of pathway,be
R1693 T3418 T3430 arg2Of pathway,involved
R1694 T3423 T3422 arg2Of PI3K,(
R1695 T3424 T3422 arg3Of ),(
R1696 T3425 T3426 arg1Of /Akt,and
R1697 T3426 T3419 arg2Of and,involving
R1698 T3426 T3420 arg1Of and,phosphoinositide
R1699 T3426 T3421 arg1Of and,3-kinase
R1700 T3426 T3422 arg1Of and,(
R1701 T3427 T3426 arg2Of NF-κB,and
R1702 T3430 T3413 arg2Of involved,found
R1703 T3430 T3414 arg1Of involved,that
R1704 T3430 T3428 arg2Of involved,might
R1705 T3430 T3429 arg2Of involved,be
R1706 T3430 T3431 arg1Of involved,in
R1707 T3433 T3431 arg2Of overproduction,in
R1708 T3433 T3432 arg1Of overproduction,the
R1709 T3433 T3434 arg1Of overproduction,of
R1710 T3439 T3434 arg2Of IL-17,of
R1711 T3439 T3435 arg1Of IL-17,the
R1712 T3439 T3436 arg1Of IL-17,key
R1713 T3439 T3437 arg1Of IL-17,inflammatory
R1714 T3439 T3438 arg1Of IL-17,cytokine
R1715 T3439 T3440 arg1Of IL-17,in
R1716 T3441 T3440 arg2Of RA,in
R1717 T3443 T3442 arg1Of results,These
R1718 T3443 T3444 arg1Of results,might
R1719 T3443 T3445 arg1Of results,provide
R1720 T3445 T3444 arg2Of provide,might
R1721 T3445 T3448 arg1Of provide,into
R1722 T3447 T3445 arg2Of insights,provide
R1723 T3447 T3446 arg1Of insights,new
R1724 T3450 T3448 arg2Of pathogenesis,into
R1725 T3450 T3449 arg1Of pathogenesis,the
R1727 T3450 T3451 arg1Of pathogenesis,of
R1729 T3450 T3456 arg1Of pathogenesis,for
R1730 T3452 T3453 arg1Of RA,and
R1733 T3453 T3451 arg2Of and,of
R1734 T3455 T3453 arg2Of directions,and
R1735 T3455 T3454 arg1Of directions,future
R1740 T3458 T3457 arg1Of therapeutic,new
R1742 T3459 T3456 arg2Of strategies,for
R1745 T3459 T3458 arg1Of strategies,therapeutic
R1747 T3459 T3460 arg1Of strategies,in
R1748 T3461 T3460 arg2Of RA,in