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PubMed:16371368 JSONTXT 55 Projects

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Id Subject Object Predicate Lexical cue
T1 108-117 Var denotes Mutations
T2 121-126 Gene denotes SHP-2
T3 127-138 Enzyme denotes phosphatase
T4 150-165 PosReg denotes hyperactivation
T5 173-191 MPA denotes catalytic activity
T33 216-231 Disease denotes human leukemias
T34 246-278 Disease denotes juvenile myelomonocytic leukemia
T10 1314-1319 Gene denotes SHP-2
T11 1320-1333 Var denotes E76K mutation
T12 1341-1375 Disease denotes myeloproliferative disease in mice
T13 1494-1547 Var denotes E76K mutation in the N-terminal Src homology 2 domain
T14 1548-1557 PosReg denotes increased
T15 1558-1570 Interaction denotes interactions
T18 1574-1580 Var denotes mutant
T17 1581-1586 Gene denotes SHP-2
T16 1592-1596 Protein denotes Grb2
T19 1624-1639 PosReg denotes hyperactivation
T20 1643-1709 Pathway denotes IL-3-induced Erk and phosphatidylinositol 3-kinase (PI3K) pathways
T25 1748-1756 PosReg denotes increase
T26 1764-1782 MPA denotes catalytic activity
T24 1784-1810 MPA denotes dephosphorylation of STAT5
T22 1814-1819 Gene denotes SHP-2
T23 1820-1824 Var denotes E76K
T21 1829-1837 NegReg denotes dampened
T27 1852-1919 Var denotes catalytically inactive SHP-2 E76K with an additional C459S mutation
T28 1947-1955 PosReg denotes increase
T29 1960-1971 Interaction denotes interaction
T30 1977-1981 Protein denotes Gab2
T31 1989-1996 PosReg denotes enhance
T32 2001-2031 Pathway denotes activation of the PI3K pathway
R1 T3 T2 ThemeOf phosphatase,SHP-2
R10 T17 T15 ThemeOf SHP-2,interactions
R11 T18 T17 ThemeOf mutant,SHP-2
R12 T14 T19 CauseOf increased,hyperactivation
R13 T20 T19 ThemeOf IL-3-induced Erk and phosphatidylinositol 3-kinase (PI3K) pathways,hyperactivation
R14 T26 T25 ThemeOf catalytic activity,increase
R15 T24 T21 ThemeOf dephosphorylation of STAT5,dampened
R16 T23 T22 ThemeOf E76K,SHP-2
R17 T22 T24 ThemeOf SHP-2,dephosphorylation of STAT5
R18 T27 T28 CauseOf catalytically inactive SHP-2 E76K with an additional C459S mutation,increase
R19 T29 T28 ThemeOf interaction,increase
R2 T2 T1 ThemeOf SHP-2,Mutations
R20 T30 T29 ThemeOf Gab2,interaction
R21 T27 T31 CauseOf catalytically inactive SHP-2 E76K with an additional C459S mutation,enhance
R22 T32 T31 ThemeOf activation of the PI3K pathway,enhance
R3 T1 T4 CauseOf Mutations,hyperactivation
R4 T5 T4 ThemeOf catalytic activity,hyperactivation
R5 T10 T11 ThemeOf SHP-2,E76K mutation
R6 T11 T12 CauseOf E76K mutation,myeloproliferative disease in mice
R7 T13 T14 CauseOf E76K mutation in the N-terminal Src homology 2 domain,increased
R8 T15 T14 ThemeOf interactions,increased
R9 T16 T15 ThemeOf Grb2,interactions