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Documents (250) JSON TSV

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PubMed 16371368 Effects of a leukemia-associated gain-of-function mutation of SHP-2 phosphatase on interleukin-3 signaling. Mutations in SHP-2 phosphatase that cause hyperactivation of its catalytic activity have bee 2.24 KB 2019-09-23 56 52
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PubMed 18594199 Conditional RNA interference in vivo to study mutant p53 oncogenic gain of function on tumor malignancy. Mutant p53 proteins are thought to have acquired a "gain of function" (GOF) activity that mainl 1.24 KB 2019-09-23 29 42
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PubMed 19338054 Identification and functional analysis of novel variants of the human melanocortin 1 receptor found in melanoma patients. The melanocortin 1 receptor, a Gs protein-coupled receptor expressed in epider 1.9 KB 2019-09-23 33 36
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PubMed 19917135 Elevated expression of p53 gain-of-function mutation R175H in endometrial cancer cells can increase the invasive phenotypes by activation of the EGFR/PI3K/AKT pathway. BACKGROUND: p53 is the most comm 1.68 KB 2019-09-23 31 70
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PubMed 20696700 Mutant p53 facilitates somatic cell reprogramming and augments the malignant potential of reprogrammed cells. p53 deficiency enhances the efficiency of somatic cell reprogramming to a pluripotent stat 1.45 KB 2019-09-23 30 70
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PubMed 21187651 Mutant p53 R248Q but not R248W enhances in vitro invasiveness of human lung cancer NCI-H1299 cells. More than half of all human cancers are associated with mutations of the TP53 gene. In regard to the 1.87 KB 2019-09-23 31 22
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PubMed 22114072 Gain-of-function mutant p53 upregulates CXC chemokines and enhances cell migration. The role of dominant transforming p53 in carcinogenesis is poorly understood. Our previous data suggested that aberr 1.85 KB 2019-09-23 34 65
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PubMed 22989750 Allele specific gain-of-function activity of p53 mutants in lung cancer cells. p53 mutations are mostly single amino acid changes resulting in expression of a stable mutant protein with "gain of funct 1.41 KB 2019-09-23 35 47
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PubMed 23967324 Clinical relevance of gain-of-function mutations of p53 in high-grade serous ovarian carcinoma. PURPOSE: Inactivation of TP53, which occurs predominantly by missense mutations in exons 4-9, is a major 1.8 KB 2019-09-23 35 42
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PubMed 24603336 Unequal prognostic potentials of p53 gain-of-function mutations in human cancers associate with drug-metabolizing activity. Mutation of p53 is the most common genetic change in human cancer, causing c 1.49 KB 2019-09-23 35 36
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