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PMC:516044 / 2015-4233 JSONTXT 5 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T770 11-18 NNP denotes Pendred
T771 19-27 NN denotes syndrome
T772 28-30 VBZ denotes is
T773 31-32 DT denotes a
T775 33-43 RB denotes relatively
T776 44-50 JJ denotes common
T777 51-60 JJ denotes autosomal
T779 60-61 HYPH denotes -
T778 61-70 JJ denotes recessive
T774 71-79 NN denotes disorder
T780 80-93 VBN denotes characterized
T781 94-96 IN denotes by
T782 97-105 NN denotes deafness
T783 106-109 CC denotes and
T784 110-116 NN denotes goiter
T785 117-118 -LRB- denotes [
T786 118-119 CD denotes 1
T787 119-120 -RRB- denotes ]
T788 120-121 . denotes .
T789 121-223 sentence denotes The syndrome is caused by mutations of the PDS gene SLC26A4, which codes for the protein pendrin [2].
T790 122-125 DT denotes The
T791 126-134 NN denotes syndrome
T793 135-137 VBZ denotes is
T792 138-144 VBN denotes caused
T794 145-147 IN denotes by
T795 148-157 NNS denotes mutations
T796 158-160 IN denotes of
T797 161-164 DT denotes the
T799 165-168 NN denotes PDS
T798 169-173 NN denotes gene
T800 174-181 NN denotes SLC26A4
T801 181-183 , denotes ,
T802 183-188 WDT denotes which
T803 189-194 VBZ denotes codes
T804 195-198 IN denotes for
T805 199-202 DT denotes the
T807 203-210 NN denotes protein
T806 211-218 NN denotes pendrin
T808 219-220 -LRB- denotes [
T809 220-221 CD denotes 2
T810 221-222 -RRB- denotes ]
T811 222-223 . denotes .
T812 223-337 sentence denotes Deafness is congenital and generally profound although sometimes late in onset and provoked by light head injury.
T813 224-232 NN denotes Deafness
T814 233-235 VBZ denotes is
T815 236-246 JJ denotes congenital
T816 247-250 CC denotes and
T817 251-260 RB denotes generally
T818 261-269 JJ denotes profound
T819 270-278 IN denotes although
T821 279-288 RB denotes sometimes
T820 289-293 JJ denotes late
T822 294-296 IN denotes in
T823 297-302 NN denotes onset
T824 303-306 CC denotes and
T825 307-315 VBN denotes provoked
T826 316-318 IN denotes by
T827 319-324 JJ denotes light
T829 325-329 NN denotes head
T828 330-336 NN denotes injury
T830 336-337 . denotes .
T831 337-373 sentence denotes Vestibular dysfunction is uncommon.
T832 338-348 JJ denotes Vestibular
T833 349-360 NN denotes dysfunction
T834 361-363 VBZ denotes is
T835 364-372 JJ denotes uncommon
T836 372-373 . denotes .
T837 373-435 sentence denotes Goiter is variable and generally develops around puberty [3].
T838 374-380 NN denotes Goiter
T839 381-383 VBZ denotes is
T840 384-392 JJ denotes variable
T841 393-396 CC denotes and
T842 397-406 RB denotes generally
T843 407-415 VBZ denotes develops
T844 416-422 IN denotes around
T845 423-430 NN denotes puberty
T846 431-432 -LRB- denotes [
T847 432-433 CD denotes 3
T848 433-434 -RRB- denotes ]
T849 434-435 . denotes .
T850 435-634 sentence denotes The cause of goiter appears to be an impairment of iodide fixation in the follicular lumen due to a reduced rate of iodide transport across the apical membrane of thyroid gland epithelial cells [4].
T851 436-439 DT denotes The
T852 440-445 NN denotes cause
T854 446-448 IN denotes of
T855 449-455 NN denotes goiter
T853 456-463 VBZ denotes appears
T856 464-466 TO denotes to
T857 467-469 VB denotes be
T858 470-472 DT denotes an
T859 473-483 NN denotes impairment
T860 484-486 IN denotes of
T861 487-493 NN denotes iodide
T862 494-502 NN denotes fixation
T863 503-505 IN denotes in
T864 506-509 DT denotes the
T866 510-520 JJ denotes follicular
T865 521-526 NN denotes lumen
T867 527-530 IN denotes due
T868 531-533 IN denotes to
T869 534-535 DT denotes a
T871 536-543 VBN denotes reduced
T870 544-548 NN denotes rate
T872 549-551 IN denotes of
T873 552-558 NN denotes iodide
T874 559-568 NN denotes transport
T875 569-575 IN denotes across
T876 576-579 DT denotes the
T878 580-586 JJ denotes apical
T877 587-595 NN denotes membrane
T879 596-598 IN denotes of
T880 599-606 JJ denotes thyroid
T881 607-612 NN denotes gland
T883 613-623 JJ denotes epithelial
T882 624-629 NNS denotes cells
T884 630-631 -LRB- denotes [
T885 631-632 CD denotes 4
T886 632-633 -RRB- denotes ]
T887 633-634 . denotes .
T888 634-779 sentence denotes A positive perchlorate discharge test and an enlarged vestibular aqueduct appear to be the most reliable clinical signs of Pendred syndrome [5].
T889 635-636 DT denotes A
T891 637-645 JJ denotes positive
T892 646-657 NN denotes perchlorate
T893 658-667 NN denotes discharge
T890 668-672 NN denotes test
T895 673-676 CC denotes and
T896 677-679 DT denotes an
T898 680-688 VBN denotes enlarged
T899 689-699 JJ denotes vestibular
T897 700-708 NN denotes aqueduct
T894 709-715 VBP denotes appear
T900 716-718 TO denotes to
T901 719-721 VB denotes be
T902 722-725 DT denotes the
T904 726-730 RBS denotes most
T905 731-739 JJ denotes reliable
T906 740-748 JJ denotes clinical
T903 749-754 NNS denotes signs
T907 755-757 IN denotes of
T908 758-765 NNP denotes Pendred
T909 766-774 NN denotes syndrome
T910 775-776 -LRB- denotes [
T911 776-777 CD denotes 5
T912 777-778 -RRB- denotes ]
T913 778-779 . denotes .
T914 779-863 sentence denotes Pendrin is an anion exchanger that can transport Cl-, I-, HCO3 - and formate [6,7].
T915 780-787 NN denotes Pendrin
T916 788-790 VBZ denotes is
T917 791-793 DT denotes an
T919 794-799 NN denotes anion
T918 800-809 NN denotes exchanger
T920 810-814 WDT denotes that
T922 815-818 MD denotes can
T921 819-828 VB denotes transport
T923 829-831 NN denotes Cl
T924 831-832 SYM denotes -
T925 832-834 , denotes ,
T926 834-835 NN denotes I
T927 835-836 SYM denotes -
T928 836-838 , denotes ,
T929 838-842 NN denotes HCO3
T930 843-844 SYM denotes -
T931 845-848 CC denotes and
T932 849-856 NN denotes formate
T933 857-858 -LRB- denotes [
T935 858-859 CD denotes 6
T936 859-860 , denotes ,
T934 860-861 CD denotes 7
T937 861-862 -RRB- denotes ]
T938 862-863 . denotes .
T939 863-991 sentence denotes Expression has been found in the inner ear and thyroid gland consistent with the clinical signs of deafness and goiter [2,3,8].
T940 864-874 NN denotes Expression
T942 875-878 VBZ denotes has
T943 879-883 VBN denotes been
T941 884-889 VBN denotes found
T944 890-892 IN denotes in
T945 893-896 DT denotes the
T947 897-902 JJ denotes inner
T946 903-906 NN denotes ear
T948 907-910 CC denotes and
T949 911-918 NN denotes thyroid
T950 919-924 NN denotes gland
T951 925-935 JJ denotes consistent
T952 936-940 IN denotes with
T953 941-944 DT denotes the
T955 945-953 JJ denotes clinical
T954 954-959 NNS denotes signs
T956 960-962 IN denotes of
T957 963-971 NN denotes deafness
T958 972-975 CC denotes and
T959 976-982 NN denotes goiter
T960 983-984 -LRB- denotes [
T962 984-985 CD denotes 2
T963 985-986 , denotes ,
T964 986-987 CD denotes 3
T965 987-988 , denotes ,
T961 988-989 CD denotes 8
T966 989-990 -RRB- denotes ]
T967 990-991 . denotes .
T968 991-1121 sentence denotes In addition, pendrin expression has been found in the kidney [9], mammary gland [10], uterus [11], testes [12] and placenta [13].
T969 992-994 IN denotes In
T971 995-1003 NN denotes addition
T972 1003-1005 , denotes ,
T973 1005-1012 NN denotes pendrin
T974 1013-1023 NN denotes expression
T975 1024-1027 VBZ denotes has
T976 1028-1032 VBN denotes been
T970 1033-1038 VBN denotes found
T977 1039-1041 IN denotes in
T978 1042-1045 DT denotes the
T979 1046-1052 NN denotes kidney
T980 1053-1054 -LRB- denotes [
T981 1054-1055 CD denotes 9
T982 1055-1056 -RRB- denotes ]
T983 1056-1058 , denotes ,
T984 1058-1065 JJ denotes mammary
T985 1066-1071 NN denotes gland
T986 1072-1073 -LRB- denotes [
T987 1073-1075 CD denotes 10
T988 1075-1076 -RRB- denotes ]
T989 1076-1078 , denotes ,
T990 1078-1084 NN denotes uterus
T991 1085-1086 -LRB- denotes [
T992 1086-1088 CD denotes 11
T993 1088-1089 -RRB- denotes ]
T994 1089-1091 , denotes ,
T995 1091-1097 NNS denotes testes
T996 1098-1099 -LRB- denotes [
T997 1099-1101 CD denotes 12
T998 1101-1102 -RRB- denotes ]
T999 1103-1106 CC denotes and
T1000 1107-1115 NN denotes placenta
T1001 1116-1117 -LRB- denotes [
T1002 1117-1119 CD denotes 13
T1003 1119-1120 -RRB- denotes ]
T1004 1120-1121 . denotes .
T1005 1121-1225 sentence denotes No expression was found in fetal or adult brain, consistent with a peripheral cause of deafness [2,11].
T1006 1122-1124 DT denotes No
T1007 1125-1135 NN denotes expression
T1009 1136-1139 VBD denotes was
T1008 1140-1145 VBN denotes found
T1010 1146-1148 IN denotes in
T1011 1149-1154 JJ denotes fetal
T1013 1155-1157 CC denotes or
T1014 1158-1163 JJ denotes adult
T1012 1164-1169 NN denotes brain
T1015 1169-1171 , denotes ,
T1016 1171-1181 JJ denotes consistent
T1017 1182-1186 IN denotes with
T1018 1187-1188 DT denotes a
T1020 1189-1199 JJ denotes peripheral
T1019 1200-1205 NN denotes cause
T1021 1206-1208 IN denotes of
T1022 1209-1217 NN denotes deafness
T1023 1218-1219 -LRB- denotes [
T1025 1219-1220 CD denotes 2
T1026 1220-1221 , denotes ,
T1024 1221-1223 CD denotes 11
T1027 1223-1224 -RRB- denotes ]
T1028 1224-1225 . denotes .
T1029 1225-1381 sentence denotes Expression of pendrin mRNA in the inner ear has been found in several places including the cochlea, the vestibular labyrinth and the endolymphatic sac [8].
T1030 1226-1236 NN denotes Expression
T1032 1237-1239 IN denotes of
T1033 1240-1247 NN denotes pendrin
T1034 1248-1252 NN denotes mRNA
T1035 1253-1255 IN denotes in
T1036 1256-1259 DT denotes the
T1038 1260-1265 JJ denotes inner
T1037 1266-1269 NN denotes ear
T1039 1270-1273 VBZ denotes has
T1040 1274-1278 VBN denotes been
T1031 1279-1284 VBN denotes found
T1041 1285-1287 IN denotes in
T1042 1288-1295 JJ denotes several
T1043 1296-1302 NNS denotes places
T1044 1303-1312 VBG denotes including
T1045 1313-1316 DT denotes the
T1046 1317-1324 NN denotes cochlea
T1047 1324-1326 , denotes ,
T1048 1326-1329 DT denotes the
T1050 1330-1340 JJ denotes vestibular
T1049 1341-1350 NN denotes labyrinth
T1051 1351-1354 CC denotes and
T1052 1355-1358 DT denotes the
T1054 1359-1372 JJ denotes endolymphatic
T1053 1373-1376 NN denotes sac
T1055 1377-1378 -LRB- denotes [
T1056 1378-1379 CD denotes 8
T1057 1379-1380 -RRB- denotes ]
T1058 1380-1381 . denotes .
T1059 1381-1471 sentence denotes The precise location of pendrin protein expression, however, has not yet been determined.
T1060 1382-1385 DT denotes The
T1062 1386-1393 JJ denotes precise
T1061 1394-1402 NN denotes location
T1064 1403-1405 IN denotes of
T1065 1406-1413 NN denotes pendrin
T1067 1414-1421 NN denotes protein
T1066 1422-1432 NN denotes expression
T1068 1432-1434 , denotes ,
T1069 1434-1441 RB denotes however
T1070 1441-1443 , denotes ,
T1071 1443-1446 VBZ denotes has
T1072 1447-1450 RB denotes not
T1073 1451-1454 RB denotes yet
T1074 1455-1459 VBN denotes been
T1063 1460-1470 VBN denotes determined
T1075 1470-1471 . denotes .
T1076 1471-1654 sentence denotes The variability of deafness in Pendred syndrome and the observation that deafness is sometimes late in onset suggest that pendrin dysfunction may not be the direct cause of deafness.
T1077 1472-1475 DT denotes The
T1078 1476-1487 NN denotes variability
T1080 1488-1490 IN denotes of
T1081 1491-1499 NN denotes deafness
T1082 1500-1502 IN denotes in
T1083 1503-1510 NNP denotes Pendred
T1084 1511-1519 NN denotes syndrome
T1085 1520-1523 CC denotes and
T1086 1524-1527 DT denotes the
T1087 1528-1539 NN denotes observation
T1088 1540-1544 IN denotes that
T1090 1545-1553 NN denotes deafness
T1089 1554-1556 VBZ denotes is
T1091 1557-1566 RB denotes sometimes
T1092 1567-1571 JJ denotes late
T1093 1572-1574 IN denotes in
T1094 1575-1580 NN denotes onset
T1079 1581-1588 VBP denotes suggest
T1095 1589-1593 IN denotes that
T1097 1594-1601 NN denotes pendrin
T1098 1602-1613 NN denotes dysfunction
T1099 1614-1617 MD denotes may
T1100 1618-1621 RB denotes not
T1096 1622-1624 VB denotes be
T1101 1625-1628 DT denotes the
T1103 1629-1635 JJ denotes direct
T1102 1636-1641 NN denotes cause
T1104 1642-1644 IN denotes of
T1105 1645-1653 NN denotes deafness
T1106 1653-1654 . denotes .
T1107 1654-1812 sentence denotes It is conceivable that pendrin dysfunction favors changes in the expression levels of proteins that are critical for the maintenance of the hearing function.
T1108 1655-1657 PRP denotes It
T1109 1658-1660 VBZ denotes is
T1110 1661-1672 JJ denotes conceivable
T1111 1673-1677 IN denotes that
T1113 1678-1685 NN denotes pendrin
T1114 1686-1697 NN denotes dysfunction
T1112 1698-1704 VBZ denotes favors
T1115 1705-1712 NNS denotes changes
T1116 1713-1715 IN denotes in
T1117 1716-1719 DT denotes the
T1119 1720-1730 NN denotes expression
T1118 1731-1737 NNS denotes levels
T1120 1738-1740 IN denotes of
T1121 1741-1749 NN denotes proteins
T1122 1750-1754 WDT denotes that
T1123 1755-1758 VBP denotes are
T1124 1759-1767 JJ denotes critical
T1125 1768-1771 IN denotes for
T1126 1772-1775 DT denotes the
T1127 1776-1787 NN denotes maintenance
T1128 1788-1790 IN denotes of
T1129 1791-1794 DT denotes the
T1131 1795-1802 NN denotes hearing
T1130 1803-1811 NN denotes function
T1132 1811-1812 . denotes .
T1133 1812-2102 sentence denotes Detailed studies aimed at identifying the direct cause of deafness in Pendred syndrome have recently become possible due to the generation of a pendrin-specific polyclonal antibody [9] and the development of Slc26a4-/- mice, which bear a targeted disruption of the mouse Slc26a4 gene [14].
T1134 1813-1821 JJ denotes Detailed
T1135 1822-1829 NNS denotes studies
T1137 1830-1835 VBN denotes aimed
T1138 1836-1838 IN denotes at
T1139 1839-1850 VBG denotes identifying
T1140 1851-1854 DT denotes the
T1142 1855-1861 JJ denotes direct
T1141 1862-1867 NN denotes cause
T1143 1868-1870 IN denotes of
T1144 1871-1879 NN denotes deafness
T1145 1880-1882 IN denotes in
T1146 1883-1890 NNP denotes Pendred
T1147 1891-1899 NN denotes syndrome
T1148 1900-1904 VBP denotes have
T1149 1905-1913 RB denotes recently
T1136 1914-1920 VB denotes become
T1150 1921-1929 JJ denotes possible
T1151 1930-1933 IN denotes due
T1152 1934-1936 IN denotes to
T1153 1937-1940 DT denotes the
T1154 1941-1951 NN denotes generation
T1155 1952-1954 IN denotes of
T1156 1955-1956 DT denotes a
T1158 1957-1964 NN denotes pendrin
T1160 1964-1965 HYPH denotes -
T1159 1965-1973 JJ denotes specific
T1161 1974-1984 JJ denotes polyclonal
T1157 1985-1993 NN denotes antibody
T1162 1994-1995 -LRB- denotes [
T1163 1995-1996 CD denotes 9
T1164 1996-1997 -RRB- denotes ]
T1165 1998-2001 CC denotes and
T1166 2002-2005 DT denotes the
T1167 2006-2017 NN denotes development
T1168 2018-2020 IN denotes of
T1169 2021-2028 NN denotes Slc26a4
T1171 2028-2029 SYM denotes -
T1172 2029-2030 HYPH denotes /
T1173 2030-2031 SYM denotes -
T1170 2032-2036 NNS denotes mice
T1174 2036-2038 , denotes ,
T1175 2038-2043 WDT denotes which
T1176 2044-2048 VBP denotes bear
T1177 2049-2050 DT denotes a
T1179 2051-2059 JJ denotes targeted
T1178 2060-2070 NN denotes disruption
T1180 2071-2073 IN denotes of
T1181 2074-2077 DT denotes the
T1183 2078-2083 NN denotes mouse
T1184 2084-2091 NN denotes Slc26a4
T1182 2092-2096 NN denotes gene
T1185 2097-2098 -LRB- denotes [
T1186 2098-2100 CD denotes 14
T1187 2100-2101 -RRB- denotes ]
T1188 2101-2102 . denotes .
T1189 2102-2218 sentence denotes The aim in the present study was to determine the location of pendrin and the cause of deafness in Slc26a4-/- mice.
T1190 2103-2106 DT denotes The
T1191 2107-2110 NN denotes aim
T1193 2111-2113 IN denotes in
T1194 2114-2117 DT denotes the
T1196 2118-2125 JJ denotes present
T1195 2126-2131 NN denotes study
T1192 2132-2135 VBD denotes was
T1197 2136-2138 TO denotes to
T1198 2139-2148 VB denotes determine
T1199 2149-2152 DT denotes the
T1200 2153-2161 NN denotes location
T1201 2162-2164 IN denotes of
T1202 2165-2172 NN denotes pendrin
T1203 2173-2176 CC denotes and
T1204 2177-2180 DT denotes the
T1205 2181-2186 NN denotes cause
T1206 2187-2189 IN denotes of
T1207 2190-2198 NN denotes deafness
T1208 2199-2201 IN denotes in
T1209 2202-2209 NN denotes Slc26a4
T1211 2209-2210 SYM denotes -
T1212 2210-2211 HYPH denotes /
T1213 2211-2212 SYM denotes -
T1210 2213-2217 NNS denotes mice
T1214 2217-2218 . denotes .
R332 T770 T771 compound Pendred,syndrome
R333 T771 T772 nsubj syndrome,is
R334 T773 T774 det a,disorder
R335 T774 T772 attr disorder,is
R336 T775 T776 advmod relatively,common
R337 T776 T774 amod common,disorder
R338 T777 T778 amod autosomal,recessive
R339 T778 T774 amod recessive,disorder
R340 T779 T778 punct -,recessive
R341 T780 T774 acl characterized,disorder
R342 T781 T780 agent by,characterized
R343 T782 T781 pobj deafness,by
R344 T783 T782 cc and,deafness
R345 T784 T782 conj goiter,deafness
R346 T785 T786 punct [,1
R347 T786 T780 parataxis 1,characterized
R348 T787 T786 punct ],1
R349 T788 T772 punct .,is
R350 T790 T791 det The,syndrome
R351 T791 T792 nsubjpass syndrome,caused
R352 T793 T792 auxpass is,caused
R353 T794 T792 agent by,caused
R354 T795 T794 pobj mutations,by
R355 T796 T795 prep of,mutations
R356 T797 T798 det the,gene
R357 T798 T796 pobj gene,of
R358 T799 T798 compound PDS,gene
R359 T800 T798 appos SLC26A4,gene
R360 T801 T798 punct ", ",gene
R361 T802 T803 dep which,codes
R362 T803 T798 relcl codes,gene
R363 T804 T803 prep for,codes
R364 T805 T806 det the,pendrin
R365 T806 T804 pobj pendrin,for
R366 T807 T806 compound protein,pendrin
R367 T808 T809 punct [,2
R368 T809 T803 parataxis 2,codes
R369 T810 T809 punct ],2
R370 T811 T792 punct .,caused
R371 T813 T814 nsubj Deafness,is
R372 T815 T814 acomp congenital,is
R373 T816 T815 cc and,congenital
R374 T817 T818 advmod generally,profound
R375 T818 T815 conj profound,congenital
R376 T819 T820 mark although,late
R377 T820 T818 advcl late,profound
R378 T821 T820 advmod sometimes,late
R379 T822 T820 prep in,late
R380 T823 T822 pobj onset,in
R381 T824 T815 cc and,congenital
R382 T825 T815 conj provoked,congenital
R383 T826 T825 agent by,provoked
R384 T827 T828 amod light,injury
R385 T828 T826 pobj injury,by
R386 T829 T828 compound head,injury
R387 T830 T814 punct .,is
R388 T832 T833 amod Vestibular,dysfunction
R389 T833 T834 nsubj dysfunction,is
R390 T835 T834 acomp uncommon,is
R391 T836 T834 punct .,is
R392 T838 T839 nsubj Goiter,is
R393 T840 T839 acomp variable,is
R394 T841 T839 cc and,is
R395 T842 T843 advmod generally,develops
R396 T843 T839 conj develops,is
R397 T844 T843 prep around,develops
R398 T845 T844 pobj puberty,around
R399 T846 T847 punct [,3
R400 T847 T843 parataxis 3,develops
R401 T848 T847 punct ],3
R402 T849 T839 punct .,is
R403 T851 T852 det The,cause
R404 T852 T853 nsubj cause,appears
R405 T854 T852 prep of,cause
R406 T855 T854 pobj goiter,of
R407 T856 T857 aux to,be
R408 T857 T853 xcomp be,appears
R409 T858 T859 det an,impairment
R410 T859 T857 attr impairment,be
R411 T860 T859 prep of,impairment
R412 T861 T862 compound iodide,fixation
R413 T862 T860 pobj fixation,of
R414 T863 T859 prep in,impairment
R415 T864 T865 det the,lumen
R416 T865 T863 pobj lumen,in
R417 T866 T865 amod follicular,lumen
R418 T867 T857 prep due,be
R419 T868 T867 pcomp to,due
R420 T869 T870 det a,rate
R421 T870 T867 pobj rate,due
R422 T871 T870 amod reduced,rate
R423 T872 T870 prep of,rate
R424 T873 T874 compound iodide,transport
R425 T874 T872 pobj transport,of
R426 T875 T874 prep across,transport
R427 T876 T877 det the,membrane
R428 T877 T875 pobj membrane,across
R429 T878 T877 amod apical,membrane
R430 T879 T877 prep of,membrane
R431 T880 T881 amod thyroid,gland
R432 T881 T882 nmod gland,cells
R433 T882 T879 pobj cells,of
R434 T883 T882 amod epithelial,cells
R435 T884 T885 punct [,4
R436 T885 T857 parataxis 4,be
R437 T886 T885 punct ],4
R438 T887 T853 punct .,appears
R439 T889 T890 det A,test
R440 T890 T894 nsubj test,appear
R441 T891 T890 amod positive,test
R442 T892 T893 compound perchlorate,discharge
R443 T893 T890 compound discharge,test
R444 T895 T890 cc and,test
R445 T896 T897 det an,aqueduct
R446 T897 T890 conj aqueduct,test
R447 T898 T897 amod enlarged,aqueduct
R448 T899 T897 amod vestibular,aqueduct
R449 T900 T901 aux to,be
R450 T901 T894 xcomp be,appear
R451 T902 T903 det the,signs
R452 T903 T901 attr signs,be
R453 T904 T905 advmod most,reliable
R454 T905 T903 amod reliable,signs
R455 T906 T903 amod clinical,signs
R456 T907 T903 prep of,signs
R457 T908 T909 compound Pendred,syndrome
R458 T909 T907 pobj syndrome,of
R459 T910 T911 punct [,5
R460 T911 T901 parataxis 5,be
R461 T912 T911 punct ],5
R462 T913 T894 punct .,appear
R463 T915 T916 nsubj Pendrin,is
R464 T917 T918 det an,exchanger
R465 T918 T916 attr exchanger,is
R466 T919 T918 compound anion,exchanger
R467 T920 T921 dep that,transport
R468 T921 T918 relcl transport,exchanger
R469 T922 T921 aux can,transport
R470 T923 T921 dobj Cl,transport
R471 T924 T923 punct -,Cl
R472 T925 T923 punct ", ",Cl
R473 T926 T923 conj I,Cl
R474 T927 T926 punct -,I
R475 T928 T926 punct ", ",I
R476 T929 T926 conj HCO3,I
R477 T930 T929 punct -,HCO3
R478 T931 T929 cc and,HCO3
R479 T932 T929 conj formate,HCO3
R480 T933 T934 punct [,7
R481 T934 T921 parataxis 7,transport
R482 T935 T934 nummod 6,7
R483 T936 T934 punct ",",7
R484 T937 T934 punct ],7
R485 T938 T916 punct .,is
R486 T940 T941 nsubjpass Expression,found
R487 T942 T941 aux has,found
R488 T943 T941 auxpass been,found
R489 T944 T941 prep in,found
R490 T945 T946 det the,ear
R491 T946 T944 pobj ear,in
R492 T947 T946 amod inner,ear
R493 T948 T946 cc and,ear
R494 T949 T950 compound thyroid,gland
R495 T950 T946 conj gland,ear
R496 T951 T941 advcl consistent,found
R497 T952 T951 prep with,consistent
R498 T953 T954 det the,signs
R499 T954 T952 pobj signs,with
R500 T955 T954 amod clinical,signs
R501 T956 T954 prep of,signs
R502 T957 T956 pobj deafness,of
R503 T958 T957 cc and,deafness
R504 T959 T957 conj goiter,deafness
R505 T960 T961 punct [,8
R506 T961 T941 parataxis 8,found
R507 T962 T961 nummod 2,8
R508 T963 T961 punct ",",8
R509 T964 T961 nummod 3,8
R510 T965 T961 punct ",",8
R511 T966 T961 punct ],8
R512 T967 T941 punct .,found
R513 T969 T970 prep In,found
R514 T971 T969 pobj addition,In
R515 T972 T970 punct ", ",found
R516 T973 T974 compound pendrin,expression
R517 T974 T970 nsubjpass expression,found
R518 T975 T970 aux has,found
R519 T976 T970 auxpass been,found
R520 T977 T970 prep in,found
R521 T978 T979 det the,kidney
R522 T979 T977 pobj kidney,in
R523 T980 T981 punct [,9
R524 T981 T979 parataxis 9,kidney
R525 T982 T981 punct ],9
R526 T983 T979 punct ", ",kidney
R527 T984 T985 amod mammary,gland
R528 T985 T979 conj gland,kidney
R529 T986 T987 punct [,10
R530 T987 T985 parataxis 10,gland
R531 T988 T987 punct ],10
R532 T989 T985 punct ", ",gland
R533 T990 T985 conj uterus,gland
R534 T991 T992 punct [,11
R535 T992 T990 parataxis 11,uterus
R536 T993 T992 punct ],11
R537 T994 T990 punct ", ",uterus
R538 T995 T990 conj testes,uterus
R539 T996 T997 punct [,12
R540 T997 T995 parataxis 12,testes
R541 T998 T997 punct ],12
R542 T999 T995 cc and,testes
R543 T1000 T995 conj placenta,testes
R544 T1001 T1002 punct [,13
R545 T1002 T1000 parataxis 13,placenta
R546 T1003 T1002 punct ],13
R547 T1004 T970 punct .,found
R548 T1006 T1007 det No,expression
R549 T1007 T1008 nsubjpass expression,found
R550 T1009 T1008 auxpass was,found
R551 T1010 T1008 prep in,found
R552 T1011 T1012 amod fetal,brain
R553 T1012 T1010 pobj brain,in
R554 T1013 T1011 cc or,fetal
R555 T1014 T1011 conj adult,fetal
R556 T1015 T1008 punct ", ",found
R557 T1016 T1008 advcl consistent,found
R558 T1017 T1016 prep with,consistent
R559 T1018 T1019 det a,cause
R560 T1019 T1017 pobj cause,with
R561 T1020 T1019 amod peripheral,cause
R562 T1021 T1019 prep of,cause
R563 T1022 T1021 pobj deafness,of
R564 T1023 T1024 punct [,11
R565 T1024 T1008 parataxis 11,found
R566 T1025 T1024 nummod 2,11
R567 T1026 T1024 punct ",",11
R568 T1027 T1024 punct ],11
R569 T1028 T1008 punct .,found
R570 T1030 T1031 nsubjpass Expression,found
R571 T1032 T1030 prep of,Expression
R572 T1033 T1034 compound pendrin,mRNA
R573 T1034 T1032 pobj mRNA,of
R574 T1035 T1030 prep in,Expression
R575 T1036 T1037 det the,ear
R576 T1037 T1035 pobj ear,in
R577 T1038 T1037 amod inner,ear
R578 T1039 T1031 aux has,found
R579 T1040 T1031 auxpass been,found
R580 T1041 T1031 prep in,found
R581 T1042 T1043 amod several,places
R582 T1043 T1041 pobj places,in
R583 T1044 T1043 prep including,places
R584 T1045 T1046 det the,cochlea
R585 T1046 T1044 pobj cochlea,including
R586 T1047 T1046 punct ", ",cochlea
R587 T1048 T1049 det the,labyrinth
R588 T1049 T1046 conj labyrinth,cochlea
R589 T1050 T1049 amod vestibular,labyrinth
R590 T1051 T1049 cc and,labyrinth
R591 T1052 T1053 det the,sac
R592 T1053 T1049 conj sac,labyrinth
R593 T1054 T1053 amod endolymphatic,sac
R594 T1055 T1056 punct [,8
R595 T1056 T1031 parataxis 8,found
R596 T1057 T1056 punct ],8
R597 T1058 T1031 punct .,found
R598 T1060 T1061 det The,location
R599 T1061 T1063 nsubjpass location,determined
R600 T1062 T1061 amod precise,location
R601 T1064 T1061 prep of,location
R602 T1065 T1066 compound pendrin,expression
R603 T1066 T1064 pobj expression,of
R604 T1067 T1066 compound protein,expression
R605 T1068 T1063 punct ", ",determined
R606 T1069 T1063 advmod however,determined
R607 T1070 T1063 punct ", ",determined
R608 T1071 T1063 aux has,determined
R609 T1072 T1063 neg not,determined
R610 T1073 T1063 advmod yet,determined
R611 T1074 T1063 auxpass been,determined
R612 T1075 T1063 punct .,determined
R613 T1077 T1078 det The,variability
R614 T1078 T1079 nsubj variability,suggest
R615 T1080 T1078 prep of,variability
R616 T1081 T1080 pobj deafness,of
R617 T1082 T1078 prep in,variability
R618 T1083 T1084 compound Pendred,syndrome
R619 T1084 T1082 pobj syndrome,in
R620 T1085 T1078 cc and,variability
R621 T1086 T1087 det the,observation
R622 T1087 T1078 conj observation,variability
R623 T1088 T1089 mark that,is
R624 T1089 T1087 acl is,observation
R625 T1090 T1089 nsubj deafness,is
R626 T1091 T1089 advmod sometimes,is
R627 T1092 T1089 acomp late,is
R628 T1093 T1089 prep in,is
R629 T1094 T1093 pobj onset,in
R630 T1095 T1096 mark that,be
R631 T1096 T1079 ccomp be,suggest
R632 T1097 T1098 compound pendrin,dysfunction
R633 T1098 T1096 nsubj dysfunction,be
R634 T1099 T1096 aux may,be
R635 T1100 T1096 neg not,be
R636 T1101 T1102 det the,cause
R637 T1102 T1096 attr cause,be
R638 T1103 T1102 amod direct,cause
R639 T1104 T1102 prep of,cause
R640 T1105 T1104 pobj deafness,of
R641 T1106 T1079 punct .,suggest
R642 T1108 T1109 nsubj It,is
R643 T1110 T1109 acomp conceivable,is
R644 T1111 T1112 mark that,favors
R645 T1112 T1109 ccomp favors,is
R646 T1113 T1114 compound pendrin,dysfunction
R647 T1114 T1112 nsubj dysfunction,favors
R648 T1115 T1112 dobj changes,favors
R649 T1116 T1115 prep in,changes
R650 T1117 T1118 det the,levels
R651 T1118 T1116 pobj levels,in
R652 T1119 T1118 compound expression,levels
R653 T1120 T1118 prep of,levels
R654 T1121 T1120 pobj proteins,of
R655 T1122 T1123 dep that,are
R656 T1123 T1121 relcl are,proteins
R657 T1124 T1123 acomp critical,are
R658 T1125 T1124 prep for,critical
R659 T1126 T1127 det the,maintenance
R660 T1127 T1125 pobj maintenance,for
R661 T1128 T1127 prep of,maintenance
R662 T1129 T1130 det the,function
R663 T1130 T1128 pobj function,of
R664 T1131 T1130 compound hearing,function
R665 T1132 T1109 punct .,is
R666 T1134 T1135 amod Detailed,studies
R667 T1135 T1136 nsubj studies,become
R668 T1137 T1135 acl aimed,studies
R669 T1138 T1137 prep at,aimed
R670 T1139 T1138 pcomp identifying,at
R671 T1140 T1141 det the,cause
R672 T1141 T1139 dobj cause,identifying
R673 T1142 T1141 amod direct,cause
R674 T1143 T1141 prep of,cause
R675 T1144 T1143 pobj deafness,of
R676 T1145 T1141 prep in,cause
R677 T1146 T1147 compound Pendred,syndrome
R678 T1147 T1145 pobj syndrome,in
R679 T1148 T1136 aux have,become
R680 T1149 T1136 advmod recently,become
R681 T1150 T1136 acomp possible,become
R682 T1151 T1136 prep due,become
R683 T1152 T1151 pcomp to,due
R684 T1153 T1154 det the,generation
R685 T1154 T1151 pobj generation,due
R686 T1155 T1154 prep of,generation
R687 T1156 T1157 det a,antibody
R688 T1157 T1155 pobj antibody,of
R689 T1158 T1159 npadvmod pendrin,specific
R690 T1159 T1157 amod specific,antibody
R691 T1160 T1159 punct -,specific
R692 T1161 T1157 amod polyclonal,antibody
R693 T1162 T1163 punct [,9
R694 T1163 T1154 parataxis 9,generation
R695 T1164 T1163 punct ],9
R696 T1165 T1154 cc and,generation
R697 T1166 T1167 det the,development
R698 T1167 T1154 conj development,generation
R699 T1168 T1167 prep of,development
R700 T1169 T1170 nmod Slc26a4,mice
R701 T1170 T1168 pobj mice,of
R702 T1171 T1169 punct -,Slc26a4
R703 T1172 T1169 punct /,Slc26a4
R704 T1173 T1169 punct -,Slc26a4
R705 T1174 T1170 punct ", ",mice
R706 T1175 T1176 dep which,bear
R707 T1176 T1170 relcl bear,mice
R708 T1177 T1178 det a,disruption
R709 T1178 T1176 dobj disruption,bear
R710 T1179 T1178 amod targeted,disruption
R711 T1180 T1178 prep of,disruption
R712 T1181 T1182 det the,gene
R713 T1182 T1180 pobj gene,of
R714 T1183 T1182 compound mouse,gene
R715 T1184 T1182 compound Slc26a4,gene
R716 T1185 T1186 punct [,14
R717 T1186 T1136 parataxis 14,become
R718 T1187 T1186 punct ],14
R719 T1188 T1136 punct .,become
R720 T1190 T1191 det The,aim
R721 T1191 T1192 nsubj aim,was
R722 T1193 T1191 prep in,aim
R723 T1194 T1195 det the,study
R724 T1195 T1193 pobj study,in
R725 T1196 T1195 amod present,study
R726 T1197 T1198 aux to,determine
R727 T1198 T1192 xcomp determine,was
R728 T1199 T1200 det the,location
R729 T1200 T1198 dobj location,determine
R730 T1201 T1200 prep of,location
R731 T1202 T1201 pobj pendrin,of
R732 T1203 T1200 cc and,location
R733 T1204 T1205 det the,cause
R734 T1205 T1200 conj cause,location
R735 T1206 T1205 prep of,cause
R736 T1207 T1206 pobj deafness,of
R737 T1208 T1198 prep in,determine
R738 T1209 T1210 nmod Slc26a4,mice
R739 T1210 T1208 pobj mice,in
R740 T1211 T1209 punct -,Slc26a4
R741 T1212 T1209 punct /,Slc26a4
R742 T1213 T1209 punct -,Slc26a4
R743 T1214 T1192 punct .,was