| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T425 |
13-21 |
JJ |
denotes |
Skeletal |
| T427 |
22-28 |
NN |
denotes |
muscle |
| T426 |
29-35 |
NNS |
denotes |
fibers |
| T429 |
36-39 |
VBP |
denotes |
are |
| T430 |
40-49 |
RB |
denotes |
generally |
| T428 |
50-60 |
VBN |
denotes |
classified |
| T431 |
61-63 |
IN |
denotes |
as |
| T432 |
64-68 |
NN |
denotes |
type |
| T434 |
69-70 |
CD |
denotes |
I |
| T435 |
71-72 |
-LRB- |
denotes |
( |
| T437 |
72-81 |
JJ |
denotes |
oxidative |
| T438 |
81-82 |
HYPH |
denotes |
/ |
| T436 |
82-86 |
JJ |
denotes |
slow |
| T439 |
86-87 |
-RRB- |
denotes |
) |
| T440 |
88-90 |
CC |
denotes |
or |
| T441 |
91-95 |
NN |
denotes |
type |
| T442 |
96-98 |
CD |
denotes |
II |
| T443 |
99-100 |
-LRB- |
denotes |
( |
| T445 |
100-110 |
JJ |
denotes |
glycolytic |
| T446 |
110-111 |
HYPH |
denotes |
/ |
| T444 |
111-115 |
JJ |
denotes |
fast |
| T447 |
115-116 |
-RRB- |
denotes |
) |
| T433 |
117-123 |
NNS |
denotes |
fibers |
| T448 |
123-124 |
. |
denotes |
. |
| T449 |
124-226 |
sentence |
denotes |
They display marked differences in respect to contraction, metabolism, and susceptibility to fatigue. |
| T450 |
125-129 |
PRP |
denotes |
They |
| T451 |
130-137 |
VBP |
denotes |
display |
| T452 |
138-144 |
JJ |
denotes |
marked |
| T453 |
145-156 |
NNS |
denotes |
differences |
| T454 |
157-159 |
IN |
denotes |
in |
| T455 |
160-167 |
NN |
denotes |
respect |
| T456 |
168-170 |
IN |
denotes |
to |
| T457 |
171-182 |
NN |
denotes |
contraction |
| T458 |
182-184 |
, |
denotes |
, |
| T459 |
184-194 |
NN |
denotes |
metabolism |
| T460 |
194-196 |
, |
denotes |
, |
| T461 |
196-199 |
CC |
denotes |
and |
| T462 |
200-214 |
NN |
denotes |
susceptibility |
| T463 |
215-217 |
IN |
denotes |
to |
| T464 |
218-225 |
NN |
denotes |
fatigue |
| T465 |
225-226 |
. |
denotes |
. |
| T466 |
226-409 |
sentence |
denotes |
Type I fibers are mitochondria-rich and mainly use oxidative metabolism for energy production, which provides a stable and long-lasting supply of ATP, and thus are fatigue-resistant. |
| T467 |
227-231 |
NN |
denotes |
Type |
| T469 |
232-233 |
CD |
denotes |
I |
| T468 |
234-240 |
NNS |
denotes |
fibers |
| T470 |
241-244 |
VBP |
denotes |
are |
| T471 |
245-257 |
NNS |
denotes |
mitochondria |
| T473 |
257-258 |
HYPH |
denotes |
- |
| T472 |
258-262 |
JJ |
denotes |
rich |
| T474 |
263-266 |
CC |
denotes |
and |
| T475 |
267-273 |
RB |
denotes |
mainly |
| T476 |
274-277 |
VBP |
denotes |
use |
| T477 |
278-287 |
JJ |
denotes |
oxidative |
| T478 |
288-298 |
NN |
denotes |
metabolism |
| T479 |
299-302 |
IN |
denotes |
for |
| T480 |
303-309 |
NN |
denotes |
energy |
| T481 |
310-320 |
NN |
denotes |
production |
| T482 |
320-322 |
, |
denotes |
, |
| T483 |
322-327 |
WDT |
denotes |
which |
| T484 |
328-336 |
VBZ |
denotes |
provides |
| T485 |
337-338 |
DT |
denotes |
a |
| T487 |
339-345 |
JJ |
denotes |
stable |
| T488 |
346-349 |
CC |
denotes |
and |
| T489 |
350-354 |
JJ |
denotes |
long |
| T491 |
354-355 |
HYPH |
denotes |
- |
| T490 |
355-362 |
VBG |
denotes |
lasting |
| T486 |
363-369 |
NN |
denotes |
supply |
| T492 |
370-372 |
IN |
denotes |
of |
| T493 |
373-376 |
NN |
denotes |
ATP |
| T494 |
376-378 |
, |
denotes |
, |
| T495 |
378-381 |
CC |
denotes |
and |
| T496 |
382-386 |
RB |
denotes |
thus |
| T497 |
387-390 |
VBP |
denotes |
are |
| T498 |
391-398 |
NN |
denotes |
fatigue |
| T500 |
398-399 |
HYPH |
denotes |
- |
| T499 |
399-408 |
JJ |
denotes |
resistant |
| T501 |
408-409 |
. |
denotes |
. |
| T502 |
409-468 |
sentence |
denotes |
Type II fibers comprise three subtypes, IIa, IIx, and IIb. |
| T503 |
410-414 |
NN |
denotes |
Type |
| T505 |
415-417 |
CD |
denotes |
II |
| T504 |
418-424 |
NNS |
denotes |
fibers |
| T506 |
425-433 |
VBP |
denotes |
comprise |
| T507 |
434-439 |
CD |
denotes |
three |
| T508 |
440-448 |
NNS |
denotes |
subtypes |
| T509 |
448-450 |
, |
denotes |
, |
| T510 |
450-453 |
NN |
denotes |
IIa |
| T511 |
453-455 |
, |
denotes |
, |
| T512 |
455-458 |
NN |
denotes |
IIx |
| T513 |
458-460 |
, |
denotes |
, |
| T514 |
460-463 |
CC |
denotes |
and |
| T515 |
464-467 |
NN |
denotes |
IIb |
| T516 |
467-468 |
. |
denotes |
. |
| T517 |
468-811 |
sentence |
denotes |
Type IIb fibers have the lowest levels of mitochondrial content and oxidative enzymes, rely on glycolytic metabolism as a major energy source, and are susceptible to fatigue, while the oxidative and contraction functions of type IIa and IIx lie between type I and IIb (Booth and Thomason 1991; Berchtold et al. 2000; Olson and Williams 2000). |
| T518 |
469-473 |
NN |
denotes |
Type |
| T519 |
474-477 |
NN |
denotes |
IIb |
| T520 |
478-484 |
NNS |
denotes |
fibers |
| T521 |
485-489 |
VBP |
denotes |
have |
| T522 |
490-493 |
DT |
denotes |
the |
| T524 |
494-500 |
JJS |
denotes |
lowest |
| T523 |
501-507 |
NNS |
denotes |
levels |
| T525 |
508-510 |
IN |
denotes |
of |
| T526 |
511-524 |
JJ |
denotes |
mitochondrial |
| T527 |
525-532 |
NN |
denotes |
content |
| T528 |
533-536 |
CC |
denotes |
and |
| T529 |
537-546 |
JJ |
denotes |
oxidative |
| T530 |
547-554 |
NNS |
denotes |
enzymes |
| T531 |
554-556 |
, |
denotes |
, |
| T532 |
556-560 |
VBP |
denotes |
rely |
| T533 |
561-563 |
IN |
denotes |
on |
| T534 |
564-574 |
JJ |
denotes |
glycolytic |
| T535 |
575-585 |
NN |
denotes |
metabolism |
| T536 |
586-588 |
IN |
denotes |
as |
| T537 |
589-590 |
DT |
denotes |
a |
| T539 |
591-596 |
JJ |
denotes |
major |
| T540 |
597-603 |
NN |
denotes |
energy |
| T538 |
604-610 |
NN |
denotes |
source |
| T541 |
610-612 |
, |
denotes |
, |
| T542 |
612-615 |
CC |
denotes |
and |
| T543 |
616-619 |
VBP |
denotes |
are |
| T544 |
620-631 |
JJ |
denotes |
susceptible |
| T545 |
632-634 |
IN |
denotes |
to |
| T546 |
635-642 |
NN |
denotes |
fatigue |
| T547 |
642-644 |
, |
denotes |
, |
| T548 |
644-649 |
IN |
denotes |
while |
| T550 |
650-653 |
DT |
denotes |
the |
| T552 |
654-663 |
JJ |
denotes |
oxidative |
| T553 |
664-667 |
CC |
denotes |
and |
| T554 |
668-679 |
NN |
denotes |
contraction |
| T551 |
680-689 |
NNS |
denotes |
functions |
| T555 |
690-692 |
IN |
denotes |
of |
| T556 |
693-697 |
NN |
denotes |
type |
| T557 |
698-701 |
NN |
denotes |
IIa |
| T558 |
702-705 |
CC |
denotes |
and |
| T559 |
706-709 |
NN |
denotes |
IIx |
| T549 |
710-713 |
VBP |
denotes |
lie |
| T560 |
714-721 |
IN |
denotes |
between |
| T561 |
722-726 |
NN |
denotes |
type |
| T563 |
727-728 |
CD |
denotes |
I |
| T564 |
729-732 |
CC |
denotes |
and |
| T562 |
733-736 |
NN |
denotes |
IIb |
| T565 |
737-738 |
-LRB- |
denotes |
( |
| T566 |
738-743 |
NNP |
denotes |
Booth |
| T567 |
744-747 |
CC |
denotes |
and |
| T568 |
748-756 |
NNP |
denotes |
Thomason |
| T569 |
757-761 |
CD |
denotes |
1991 |
| T570 |
761-762 |
: |
denotes |
; |
| T571 |
763-772 |
NNP |
denotes |
Berchtold |
| T572 |
773-775 |
FW |
denotes |
et |
| T573 |
776-779 |
FW |
denotes |
al. |
| T574 |
780-784 |
CD |
denotes |
2000 |
| T575 |
784-785 |
: |
denotes |
; |
| T576 |
786-791 |
NNP |
denotes |
Olson |
| T577 |
792-795 |
CC |
denotes |
and |
| T578 |
796-804 |
NNP |
denotes |
Williams |
| T579 |
805-809 |
CD |
denotes |
2000 |
| T580 |
809-810 |
-RRB- |
denotes |
) |
| T581 |
810-811 |
. |
denotes |
. |
| T582 |
811-1072 |
sentence |
denotes |
Adult skeletal muscle shows plasticity and can undergo conversion between different fiber types in response to exercise training or modulation of motoneuron activity (Booth and Thomason 1991, Jarvis et al. 1996; Pette 1998; Olson and Williams 2000; Hood 2001). |
| T583 |
812-817 |
JJ |
denotes |
Adult |
| T585 |
818-826 |
JJ |
denotes |
skeletal |
| T584 |
827-833 |
NN |
denotes |
muscle |
| T586 |
834-839 |
VBZ |
denotes |
shows |
| T587 |
840-850 |
NN |
denotes |
plasticity |
| T588 |
851-854 |
CC |
denotes |
and |
| T589 |
855-858 |
MD |
denotes |
can |
| T590 |
859-866 |
VB |
denotes |
undergo |
| T591 |
867-877 |
NN |
denotes |
conversion |
| T592 |
878-885 |
IN |
denotes |
between |
| T593 |
886-895 |
JJ |
denotes |
different |
| T595 |
896-901 |
NN |
denotes |
fiber |
| T594 |
902-907 |
NNS |
denotes |
types |
| T596 |
908-910 |
IN |
denotes |
in |
| T597 |
911-919 |
NN |
denotes |
response |
| T598 |
920-922 |
IN |
denotes |
to |
| T599 |
923-931 |
NN |
denotes |
exercise |
| T600 |
932-940 |
NN |
denotes |
training |
| T601 |
941-943 |
CC |
denotes |
or |
| T602 |
944-954 |
NN |
denotes |
modulation |
| T603 |
955-957 |
IN |
denotes |
of |
| T604 |
958-968 |
NN |
denotes |
motoneuron |
| T605 |
969-977 |
NN |
denotes |
activity |
| T606 |
978-979 |
-LRB- |
denotes |
( |
| T607 |
979-984 |
NNP |
denotes |
Booth |
| T608 |
985-988 |
CC |
denotes |
and |
| T609 |
989-997 |
NNP |
denotes |
Thomason |
| T610 |
998-1002 |
CD |
denotes |
1991 |
| T611 |
1002-1004 |
, |
denotes |
, |
| T612 |
1004-1010 |
NNP |
denotes |
Jarvis |
| T613 |
1011-1013 |
FW |
denotes |
et |
| T614 |
1014-1017 |
FW |
denotes |
al. |
| T615 |
1018-1022 |
CD |
denotes |
1996 |
| T616 |
1022-1023 |
: |
denotes |
; |
| T617 |
1024-1029 |
NNP |
denotes |
Pette |
| T618 |
1030-1034 |
CD |
denotes |
1998 |
| T619 |
1034-1035 |
: |
denotes |
; |
| T620 |
1036-1041 |
NNP |
denotes |
Olson |
| T621 |
1042-1045 |
CC |
denotes |
and |
| T622 |
1046-1054 |
NNP |
denotes |
Williams |
| T623 |
1055-1059 |
CD |
denotes |
2000 |
| T624 |
1059-1060 |
: |
denotes |
; |
| T625 |
1061-1065 |
NNP |
denotes |
Hood |
| T626 |
1066-1070 |
CD |
denotes |
2001 |
| T627 |
1070-1071 |
-RRB- |
denotes |
) |
| T628 |
1071-1072 |
. |
denotes |
. |
| T629 |
1072-1437 |
sentence |
denotes |
This conversion of muscle fiber from type IIb to type IIa and type I is likely to be mediated by a calcium signaling pathway that involves calcineurin, calmodulin-dependent kinase, and the transcriptional cofactor Peroxisome proliferator-activated receptor-gamma coactivator 1α (PGC-1α) (Naya et al. 2000; Olson and Williams 2000; Lin et al. 2002; Wu et al. 2002). |
| T630 |
1073-1077 |
DT |
denotes |
This |
| T631 |
1078-1088 |
NN |
denotes |
conversion |
| T633 |
1089-1091 |
IN |
denotes |
of |
| T634 |
1092-1098 |
NN |
denotes |
muscle |
| T635 |
1099-1104 |
NN |
denotes |
fiber |
| T636 |
1105-1109 |
IN |
denotes |
from |
| T637 |
1110-1114 |
NN |
denotes |
type |
| T638 |
1115-1118 |
NN |
denotes |
IIb |
| T639 |
1119-1121 |
IN |
denotes |
to |
| T640 |
1122-1126 |
NN |
denotes |
type |
| T641 |
1127-1130 |
NN |
denotes |
IIa |
| T642 |
1131-1134 |
CC |
denotes |
and |
| T643 |
1135-1139 |
NN |
denotes |
type |
| T644 |
1140-1141 |
CD |
denotes |
I |
| T632 |
1142-1144 |
VBZ |
denotes |
is |
| T645 |
1145-1151 |
JJ |
denotes |
likely |
| T646 |
1152-1154 |
TO |
denotes |
to |
| T648 |
1155-1157 |
VB |
denotes |
be |
| T647 |
1158-1166 |
VBN |
denotes |
mediated |
| T649 |
1167-1169 |
IN |
denotes |
by |
| T650 |
1170-1171 |
DT |
denotes |
a |
| T652 |
1172-1179 |
NN |
denotes |
calcium |
| T653 |
1180-1189 |
NN |
denotes |
signaling |
| T651 |
1190-1197 |
NN |
denotes |
pathway |
| T654 |
1198-1202 |
WDT |
denotes |
that |
| T655 |
1203-1211 |
VBZ |
denotes |
involves |
| T656 |
1212-1223 |
NN |
denotes |
calcineurin |
| T657 |
1223-1225 |
, |
denotes |
, |
| T658 |
1225-1235 |
NN |
denotes |
calmodulin |
| T660 |
1235-1236 |
HYPH |
denotes |
- |
| T659 |
1236-1245 |
JJ |
denotes |
dependent |
| T661 |
1246-1252 |
NN |
denotes |
kinase |
| T662 |
1252-1254 |
, |
denotes |
, |
| T663 |
1254-1257 |
CC |
denotes |
and |
| T664 |
1258-1261 |
DT |
denotes |
the |
| T666 |
1262-1277 |
JJ |
denotes |
transcriptional |
| T665 |
1278-1286 |
NN |
denotes |
cofactor |
| T667 |
1287-1297 |
NN |
denotes |
Peroxisome |
| T668 |
1298-1310 |
NN |
denotes |
proliferator |
| T670 |
1310-1311 |
HYPH |
denotes |
- |
| T669 |
1311-1320 |
VBN |
denotes |
activated |
| T671 |
1321-1329 |
NN |
denotes |
receptor |
| T673 |
1329-1330 |
HYPH |
denotes |
- |
| T674 |
1330-1335 |
NN |
denotes |
gamma |
| T672 |
1336-1347 |
NN |
denotes |
coactivator |
| T675 |
1348-1350 |
CD |
denotes |
1α |
| T676 |
1351-1352 |
-LRB- |
denotes |
( |
| T677 |
1352-1355 |
NN |
denotes |
PGC |
| T679 |
1355-1356 |
HYPH |
denotes |
- |
| T678 |
1356-1358 |
NN |
denotes |
1α |
| T680 |
1358-1359 |
-RRB- |
denotes |
) |
| T681 |
1360-1361 |
-LRB- |
denotes |
( |
| T682 |
1361-1365 |
NNP |
denotes |
Naya |
| T683 |
1366-1368 |
FW |
denotes |
et |
| T684 |
1369-1372 |
FW |
denotes |
al. |
| T685 |
1373-1377 |
CD |
denotes |
2000 |
| T686 |
1377-1378 |
: |
denotes |
; |
| T687 |
1379-1384 |
NNP |
denotes |
Olson |
| T688 |
1385-1388 |
CC |
denotes |
and |
| T689 |
1389-1397 |
NNP |
denotes |
Williams |
| T690 |
1398-1402 |
CD |
denotes |
2000 |
| T691 |
1402-1403 |
: |
denotes |
; |
| T692 |
1404-1407 |
NNP |
denotes |
Lin |
| T693 |
1408-1410 |
FW |
denotes |
et |
| T694 |
1411-1414 |
FW |
denotes |
al. |
| T695 |
1415-1419 |
CD |
denotes |
2002 |
| T696 |
1419-1420 |
: |
denotes |
; |
| T697 |
1421-1423 |
NNP |
denotes |
Wu |
| T698 |
1424-1426 |
FW |
denotes |
et |
| T699 |
1427-1430 |
FW |
denotes |
al. |
| T700 |
1431-1435 |
CD |
denotes |
2002 |
| T701 |
1435-1436 |
-RRB- |
denotes |
) |
| T702 |
1436-1437 |
. |
denotes |
. |
| T703 |
1437-1598 |
sentence |
denotes |
However, the targeted transcriptional factors directly responsible for reprogramming the fiber-specific contractile and metabolic genes remain to be identified. |
| T704 |
1438-1445 |
RB |
denotes |
However |
| T706 |
1445-1447 |
, |
denotes |
, |
| T707 |
1447-1450 |
DT |
denotes |
the |
| T709 |
1451-1459 |
VBN |
denotes |
targeted |
| T710 |
1460-1475 |
JJ |
denotes |
transcriptional |
| T708 |
1476-1483 |
NNS |
denotes |
factors |
| T711 |
1484-1492 |
RB |
denotes |
directly |
| T712 |
1493-1504 |
JJ |
denotes |
responsible |
| T713 |
1505-1508 |
IN |
denotes |
for |
| T714 |
1509-1522 |
VBG |
denotes |
reprogramming |
| T715 |
1523-1526 |
DT |
denotes |
the |
| T717 |
1527-1532 |
NN |
denotes |
fiber |
| T719 |
1532-1533 |
HYPH |
denotes |
- |
| T718 |
1533-1541 |
JJ |
denotes |
specific |
| T720 |
1542-1553 |
JJ |
denotes |
contractile |
| T721 |
1554-1557 |
CC |
denotes |
and |
| T722 |
1558-1567 |
JJ |
denotes |
metabolic |
| T716 |
1568-1573 |
NNS |
denotes |
genes |
| T705 |
1574-1580 |
VBP |
denotes |
remain |
| T723 |
1581-1583 |
TO |
denotes |
to |
| T725 |
1584-1586 |
VB |
denotes |
be |
| T724 |
1587-1597 |
VBN |
denotes |
identified |
| T726 |
1597-1598 |
. |
denotes |
. |
| T727 |
1598-1677 |
sentence |
denotes |
Muscle fiber specification appears to be associated with obesity and diabetes. |
| T728 |
1599-1605 |
NN |
denotes |
Muscle |
| T730 |
1606-1611 |
NN |
denotes |
fiber |
| T729 |
1612-1625 |
NN |
denotes |
specification |
| T731 |
1626-1633 |
VBZ |
denotes |
appears |
| T732 |
1634-1636 |
TO |
denotes |
to |
| T734 |
1637-1639 |
VB |
denotes |
be |
| T733 |
1640-1650 |
VBN |
denotes |
associated |
| T735 |
1651-1655 |
IN |
denotes |
with |
| T736 |
1656-1663 |
NN |
denotes |
obesity |
| T737 |
1664-1667 |
CC |
denotes |
and |
| T738 |
1668-1676 |
NN |
denotes |
diabetes |
| T739 |
1676-1677 |
. |
denotes |
. |
| T740 |
1677-1791 |
sentence |
denotes |
For instance, rodents that gain the most weight on high-fat diets possess fewer type I fibers (Abou et al. 1992). |
| T741 |
1678-1681 |
IN |
denotes |
For |
| T743 |
1682-1690 |
NN |
denotes |
instance |
| T744 |
1690-1692 |
, |
denotes |
, |
| T745 |
1692-1699 |
NNS |
denotes |
rodents |
| T746 |
1700-1704 |
WDT |
denotes |
that |
| T747 |
1705-1709 |
VBP |
denotes |
gain |
| T748 |
1710-1713 |
DT |
denotes |
the |
| T750 |
1714-1718 |
JJS |
denotes |
most |
| T749 |
1719-1725 |
NN |
denotes |
weight |
| T751 |
1726-1728 |
IN |
denotes |
on |
| T752 |
1729-1733 |
JJ |
denotes |
high |
| T754 |
1733-1734 |
HYPH |
denotes |
- |
| T753 |
1734-1737 |
NN |
denotes |
fat |
| T755 |
1738-1743 |
NNS |
denotes |
diets |
| T742 |
1744-1751 |
VBP |
denotes |
possess |
| T756 |
1752-1757 |
JJR |
denotes |
fewer |
| T758 |
1758-1762 |
NN |
denotes |
type |
| T759 |
1763-1764 |
CD |
denotes |
I |
| T757 |
1765-1771 |
NNS |
denotes |
fibers |
| T760 |
1772-1773 |
-LRB- |
denotes |
( |
| T761 |
1773-1777 |
NNP |
denotes |
Abou |
| T762 |
1778-1780 |
FW |
denotes |
et |
| T763 |
1781-1784 |
FW |
denotes |
al. |
| T764 |
1785-1789 |
CD |
denotes |
1992 |
| T765 |
1789-1790 |
-RRB- |
denotes |
) |
| T766 |
1790-1791 |
. |
denotes |
. |
| T767 |
1791-1997 |
sentence |
denotes |
In obese patients, skeletal muscle has been observed to have reduced oxidative capacity, increased glycolytic capacity, and a decreased percentage of type I fibers (Hickey et al. 1995; Tanner et al. 2002). |
| T768 |
1792-1794 |
IN |
denotes |
In |
| T770 |
1795-1800 |
JJ |
denotes |
obese |
| T771 |
1801-1809 |
NNS |
denotes |
patients |
| T772 |
1809-1811 |
, |
denotes |
, |
| T773 |
1811-1819 |
JJ |
denotes |
skeletal |
| T774 |
1820-1826 |
NN |
denotes |
muscle |
| T775 |
1827-1830 |
VBZ |
denotes |
has |
| T776 |
1831-1835 |
VBN |
denotes |
been |
| T769 |
1836-1844 |
VBN |
denotes |
observed |
| T777 |
1845-1847 |
TO |
denotes |
to |
| T778 |
1848-1852 |
VB |
denotes |
have |
| T779 |
1853-1860 |
VBN |
denotes |
reduced |
| T781 |
1861-1870 |
JJ |
denotes |
oxidative |
| T780 |
1871-1879 |
NN |
denotes |
capacity |
| T782 |
1879-1881 |
, |
denotes |
, |
| T783 |
1881-1890 |
VBN |
denotes |
increased |
| T785 |
1891-1901 |
JJ |
denotes |
glycolytic |
| T784 |
1902-1910 |
NN |
denotes |
capacity |
| T786 |
1910-1912 |
, |
denotes |
, |
| T787 |
1912-1915 |
CC |
denotes |
and |
| T788 |
1916-1917 |
DT |
denotes |
a |
| T790 |
1918-1927 |
VBN |
denotes |
decreased |
| T789 |
1928-1938 |
NN |
denotes |
percentage |
| T791 |
1939-1941 |
IN |
denotes |
of |
| T792 |
1942-1946 |
NN |
denotes |
type |
| T794 |
1947-1948 |
CD |
denotes |
I |
| T793 |
1949-1955 |
NNS |
denotes |
fibers |
| T795 |
1956-1957 |
-LRB- |
denotes |
( |
| T796 |
1957-1963 |
NNP |
denotes |
Hickey |
| T797 |
1964-1966 |
FW |
denotes |
et |
| T798 |
1967-1970 |
FW |
denotes |
al. |
| T799 |
1971-1975 |
CD |
denotes |
1995 |
| T800 |
1975-1976 |
: |
denotes |
; |
| T801 |
1977-1983 |
NNP |
denotes |
Tanner |
| T802 |
1984-1986 |
FW |
denotes |
et |
| T803 |
1987-1990 |
FW |
denotes |
al. |
| T804 |
1991-1995 |
CD |
denotes |
2002 |
| T805 |
1995-1996 |
-RRB- |
denotes |
) |
| T806 |
1996-1997 |
. |
denotes |
. |
| T807 |
1997-2105 |
sentence |
denotes |
Similar observations have been made in type 2 diabetic patients (Lillioja et al. 1987; Hickey et al. 1995). |
| T808 |
1998-2005 |
JJ |
denotes |
Similar |
| T809 |
2006-2018 |
NNS |
denotes |
observations |
| T811 |
2019-2023 |
VBP |
denotes |
have |
| T812 |
2024-2028 |
VBN |
denotes |
been |
| T810 |
2029-2033 |
VBN |
denotes |
made |
| T813 |
2034-2036 |
IN |
denotes |
in |
| T814 |
2037-2041 |
NN |
denotes |
type |
| T816 |
2042-2043 |
CD |
denotes |
2 |
| T815 |
2044-2052 |
JJ |
denotes |
diabetic |
| T817 |
2053-2061 |
NNS |
denotes |
patients |
| T818 |
2062-2063 |
-LRB- |
denotes |
( |
| T819 |
2063-2071 |
NNP |
denotes |
Lillioja |
| T820 |
2072-2074 |
FW |
denotes |
et |
| T821 |
2075-2078 |
FW |
denotes |
al. |
| T822 |
2079-2083 |
CD |
denotes |
1987 |
| T823 |
2083-2084 |
: |
denotes |
; |
| T824 |
2085-2091 |
NNP |
denotes |
Hickey |
| T825 |
2092-2094 |
FW |
denotes |
et |
| T826 |
2095-2098 |
FW |
denotes |
al. |
| T827 |
2099-2103 |
CD |
denotes |
1995 |
| T828 |
2103-2104 |
-RRB- |
denotes |
) |
| T829 |
2104-2105 |
. |
denotes |
. |
| T830 |
2105-2270 |
sentence |
denotes |
Recently, it has been shown that increasing oxidative fibers can lead to improved insulin action and reduced adipocyte size (Luquet et al. 2003; Ryder et al. 2003). |
| T831 |
2106-2114 |
RB |
denotes |
Recently |
| T833 |
2114-2116 |
, |
denotes |
, |
| T834 |
2116-2118 |
PRP |
denotes |
it |
| T835 |
2119-2122 |
VBZ |
denotes |
has |
| T836 |
2123-2127 |
VBN |
denotes |
been |
| T832 |
2128-2133 |
VBN |
denotes |
shown |
| T837 |
2134-2138 |
IN |
denotes |
that |
| T839 |
2139-2149 |
VBG |
denotes |
increasing |
| T841 |
2150-2159 |
JJ |
denotes |
oxidative |
| T840 |
2160-2166 |
NNS |
denotes |
fibers |
| T842 |
2167-2170 |
MD |
denotes |
can |
| T838 |
2171-2175 |
VB |
denotes |
lead |
| T843 |
2176-2178 |
IN |
denotes |
to |
| T844 |
2179-2187 |
VBN |
denotes |
improved |
| T846 |
2188-2195 |
NN |
denotes |
insulin |
| T845 |
2196-2202 |
NN |
denotes |
action |
| T847 |
2203-2206 |
CC |
denotes |
and |
| T848 |
2207-2214 |
VBN |
denotes |
reduced |
| T850 |
2215-2224 |
NN |
denotes |
adipocyte |
| T849 |
2225-2229 |
NN |
denotes |
size |
| T851 |
2230-2231 |
-LRB- |
denotes |
( |
| T852 |
2231-2237 |
NNP |
denotes |
Luquet |
| T853 |
2238-2240 |
FW |
denotes |
et |
| T854 |
2241-2244 |
FW |
denotes |
al. |
| T855 |
2245-2249 |
CD |
denotes |
2003 |
| T856 |
2249-2250 |
: |
denotes |
; |
| T857 |
2251-2256 |
NNP |
denotes |
Ryder |
| T858 |
2257-2259 |
FW |
denotes |
et |
| T859 |
2260-2263 |
FW |
denotes |
al. |
| T860 |
2264-2268 |
CD |
denotes |
2003 |
| T861 |
2268-2269 |
-RRB- |
denotes |
) |
| T862 |
2269-2270 |
. |
denotes |
. |
| T863 |
2270-2528 |
sentence |
denotes |
We have previously established that peroxisome proliferator-activated receptor (PPAR) δ is a major transcriptional regulator of fat burning in adipose tissue through activation of enzymes associated with long-chain fatty-acid β-oxidation (Wang et al. 2003). |
| T864 |
2271-2273 |
PRP |
denotes |
We |
| T866 |
2274-2278 |
VBP |
denotes |
have |
| T867 |
2279-2289 |
RB |
denotes |
previously |
| T865 |
2290-2301 |
VBN |
denotes |
established |
| T868 |
2302-2306 |
IN |
denotes |
that |
| T870 |
2307-2317 |
NN |
denotes |
peroxisome |
| T871 |
2318-2330 |
NN |
denotes |
proliferator |
| T873 |
2330-2331 |
HYPH |
denotes |
- |
| T872 |
2331-2340 |
VBN |
denotes |
activated |
| T874 |
2341-2349 |
NN |
denotes |
receptor |
| T875 |
2350-2351 |
-LRB- |
denotes |
( |
| T876 |
2351-2355 |
NN |
denotes |
PPAR |
| T877 |
2355-2356 |
-RRB- |
denotes |
) |
| T878 |
2357-2358 |
SYM |
denotes |
δ |
| T869 |
2359-2361 |
VBZ |
denotes |
is |
| T879 |
2362-2363 |
DT |
denotes |
a |
| T881 |
2364-2369 |
JJ |
denotes |
major |
| T882 |
2370-2385 |
JJ |
denotes |
transcriptional |
| T880 |
2386-2395 |
NN |
denotes |
regulator |
| T883 |
2396-2398 |
IN |
denotes |
of |
| T884 |
2399-2402 |
NN |
denotes |
fat |
| T885 |
2403-2410 |
NN |
denotes |
burning |
| T886 |
2411-2413 |
IN |
denotes |
in |
| T887 |
2414-2421 |
NN |
denotes |
adipose |
| T888 |
2422-2428 |
NN |
denotes |
tissue |
| T889 |
2429-2436 |
IN |
denotes |
through |
| T890 |
2437-2447 |
NN |
denotes |
activation |
| T891 |
2448-2450 |
IN |
denotes |
of |
| T892 |
2451-2458 |
NNS |
denotes |
enzymes |
| T893 |
2459-2469 |
VBN |
denotes |
associated |
| T894 |
2470-2474 |
IN |
denotes |
with |
| T895 |
2475-2479 |
JJ |
denotes |
long |
| T897 |
2479-2480 |
HYPH |
denotes |
- |
| T896 |
2480-2485 |
NN |
denotes |
chain |
| T899 |
2486-2491 |
JJ |
denotes |
fatty |
| T901 |
2491-2492 |
HYPH |
denotes |
- |
| T900 |
2492-2496 |
NN |
denotes |
acid |
| T902 |
2497-2498 |
NN |
denotes |
β |
| T903 |
2498-2499 |
HYPH |
denotes |
- |
| T898 |
2499-2508 |
NN |
denotes |
oxidation |
| T904 |
2509-2510 |
-LRB- |
denotes |
( |
| T905 |
2510-2514 |
NNP |
denotes |
Wang |
| T906 |
2515-2517 |
FW |
denotes |
et |
| T907 |
2518-2521 |
FW |
denotes |
al. |
| T908 |
2522-2526 |
CD |
denotes |
2003 |
| T909 |
2526-2527 |
-RRB- |
denotes |
) |
| T910 |
2527-2528 |
. |
denotes |
. |
| T911 |
2528-2649 |
sentence |
denotes |
Although PPARδ is the predominant PPAR isoform present in skeletal muscle, its in vivo function has not been determined. |
| T912 |
2529-2537 |
IN |
denotes |
Although |
| T914 |
2538-2543 |
NN |
denotes |
PPARδ |
| T913 |
2544-2546 |
VBZ |
denotes |
is |
| T916 |
2547-2550 |
DT |
denotes |
the |
| T918 |
2551-2562 |
JJ |
denotes |
predominant |
| T919 |
2563-2567 |
NN |
denotes |
PPAR |
| T917 |
2568-2575 |
NN |
denotes |
isoform |
| T920 |
2576-2583 |
JJ |
denotes |
present |
| T921 |
2584-2586 |
IN |
denotes |
in |
| T922 |
2587-2595 |
JJ |
denotes |
skeletal |
| T923 |
2596-2602 |
NN |
denotes |
muscle |
| T924 |
2602-2604 |
, |
denotes |
, |
| T925 |
2604-2607 |
PRP$ |
denotes |
its |
| T927 |
2608-2610 |
FW |
denotes |
in |
| T928 |
2611-2615 |
FW |
denotes |
vivo |
| T926 |
2616-2624 |
NN |
denotes |
function |
| T929 |
2625-2628 |
VBZ |
denotes |
has |
| T930 |
2629-2632 |
RB |
denotes |
not |
| T931 |
2633-2637 |
VBN |
denotes |
been |
| T915 |
2638-2648 |
VBN |
denotes |
determined |
| T932 |
2648-2649 |
. |
denotes |
. |
| T933 |
2649-2903 |
sentence |
denotes |
Our current study uncovers PPARδ as the first transcription factor able to drive the formation of functional type I muscle fibers, whose activation entrains complex pathways both enhancing physical performance and creating a state of obesity resistance. |
| T934 |
2650-2653 |
PRP$ |
denotes |
Our |
| T936 |
2654-2661 |
JJ |
denotes |
current |
| T935 |
2662-2667 |
NN |
denotes |
study |
| T937 |
2668-2676 |
VBZ |
denotes |
uncovers |
| T938 |
2677-2682 |
NN |
denotes |
PPARδ |
| T939 |
2683-2685 |
IN |
denotes |
as |
| T940 |
2686-2689 |
DT |
denotes |
the |
| T942 |
2690-2695 |
JJ |
denotes |
first |
| T943 |
2696-2709 |
NN |
denotes |
transcription |
| T941 |
2710-2716 |
NN |
denotes |
factor |
| T944 |
2717-2721 |
JJ |
denotes |
able |
| T945 |
2722-2724 |
TO |
denotes |
to |
| T946 |
2725-2730 |
VB |
denotes |
drive |
| T947 |
2731-2734 |
DT |
denotes |
the |
| T948 |
2735-2744 |
NN |
denotes |
formation |
| T949 |
2745-2747 |
IN |
denotes |
of |
| T950 |
2748-2758 |
JJ |
denotes |
functional |
| T952 |
2759-2763 |
NN |
denotes |
type |
| T953 |
2764-2765 |
CD |
denotes |
I |
| T954 |
2766-2772 |
NN |
denotes |
muscle |
| T951 |
2773-2779 |
NNS |
denotes |
fibers |
| T955 |
2779-2781 |
, |
denotes |
, |
| T956 |
2781-2786 |
WP$ |
denotes |
whose |
| T957 |
2787-2797 |
NN |
denotes |
activation |
| T958 |
2798-2806 |
VBZ |
denotes |
entrains |
| T959 |
2807-2814 |
JJ |
denotes |
complex |
| T960 |
2815-2823 |
NNS |
denotes |
pathways |
| T961 |
2824-2828 |
CC |
denotes |
both |
| T962 |
2829-2838 |
VBG |
denotes |
enhancing |
| T963 |
2839-2847 |
JJ |
denotes |
physical |
| T964 |
2848-2859 |
NN |
denotes |
performance |
| T965 |
2860-2863 |
CC |
denotes |
and |
| T966 |
2864-2872 |
VBG |
denotes |
creating |
| T967 |
2873-2874 |
DT |
denotes |
a |
| T968 |
2875-2880 |
NN |
denotes |
state |
| T969 |
2881-2883 |
IN |
denotes |
of |
| T970 |
2884-2891 |
NN |
denotes |
obesity |
| T971 |
2892-2902 |
NN |
denotes |
resistance |
| T972 |
2902-2903 |
. |
denotes |
. |
| R190 |
T425 |
T426 |
amod |
Skeletal,fibers |
| R191 |
T426 |
T428 |
nsubjpass |
fibers,classified |
| R192 |
T427 |
T426 |
compound |
muscle,fibers |
| R193 |
T429 |
T428 |
auxpass |
are,classified |
| R194 |
T430 |
T428 |
advmod |
generally,classified |
| R195 |
T431 |
T428 |
prep |
as,classified |
| R196 |
T432 |
T433 |
nmod |
type,fibers |
| R197 |
T433 |
T431 |
pobj |
fibers,as |
| R198 |
T434 |
T432 |
nummod |
I,type |
| R199 |
T435 |
T436 |
punct |
(,slow |
| R200 |
T436 |
T432 |
parataxis |
slow,type |
| R201 |
T437 |
T436 |
amod |
oxidative,slow |
| R202 |
T438 |
T436 |
punct |
/,slow |
| R203 |
T439 |
T436 |
punct |
),slow |
| R204 |
T440 |
T432 |
cc |
or,type |
| R205 |
T441 |
T432 |
conj |
type,type |
| R206 |
T442 |
T441 |
nummod |
II,type |
| R207 |
T443 |
T444 |
punct |
(,fast |
| R208 |
T444 |
T441 |
parataxis |
fast,type |
| R209 |
T445 |
T444 |
amod |
glycolytic,fast |
| R210 |
T446 |
T444 |
punct |
/,fast |
| R211 |
T447 |
T444 |
punct |
),fast |
| R212 |
T448 |
T428 |
punct |
.,classified |
| R213 |
T450 |
T451 |
nsubj |
They,display |
| R214 |
T452 |
T453 |
amod |
marked,differences |
| R215 |
T453 |
T451 |
dobj |
differences,display |
| R216 |
T454 |
T451 |
prep |
in,display |
| R217 |
T455 |
T454 |
pobj |
respect,in |
| R218 |
T456 |
T455 |
prep |
to,respect |
| R219 |
T457 |
T456 |
pobj |
contraction,to |
| R220 |
T458 |
T457 |
punct |
", ",contraction |
| R221 |
T459 |
T457 |
conj |
metabolism,contraction |
| R222 |
T460 |
T459 |
punct |
", ",metabolism |
| R223 |
T461 |
T459 |
cc |
and,metabolism |
| R224 |
T462 |
T459 |
conj |
susceptibility,metabolism |
| R225 |
T463 |
T462 |
prep |
to,susceptibility |
| R226 |
T464 |
T463 |
pobj |
fatigue,to |
| R227 |
T465 |
T451 |
punct |
.,display |
| R228 |
T467 |
T468 |
nmod |
Type,fibers |
| R229 |
T468 |
T470 |
nsubj |
fibers,are |
| R230 |
T469 |
T467 |
nummod |
I,Type |
| R231 |
T471 |
T472 |
npadvmod |
mitochondria,rich |
| R232 |
T472 |
T470 |
acomp |
rich,are |
| R233 |
T473 |
T472 |
punct |
-,rich |
| R234 |
T474 |
T470 |
cc |
and,are |
| R235 |
T475 |
T476 |
advmod |
mainly,use |
| R236 |
T476 |
T470 |
conj |
use,are |
| R237 |
T477 |
T478 |
amod |
oxidative,metabolism |
| R238 |
T478 |
T476 |
dobj |
metabolism,use |
| R239 |
T479 |
T476 |
prep |
for,use |
| R240 |
T480 |
T481 |
compound |
energy,production |
| R241 |
T481 |
T479 |
pobj |
production,for |
| R242 |
T482 |
T476 |
punct |
", ",use |
| R243 |
T483 |
T484 |
dep |
which,provides |
| R244 |
T484 |
T476 |
ccomp |
provides,use |
| R245 |
T485 |
T486 |
det |
a,supply |
| R246 |
T486 |
T484 |
dobj |
supply,provides |
| R247 |
T487 |
T486 |
amod |
stable,supply |
| R248 |
T488 |
T487 |
cc |
and,stable |
| R249 |
T489 |
T490 |
amod |
long,lasting |
| R250 |
T490 |
T487 |
conj |
lasting,stable |
| R251 |
T491 |
T490 |
punct |
-,lasting |
| R252 |
T492 |
T486 |
prep |
of,supply |
| R253 |
T493 |
T492 |
pobj |
ATP,of |
| R254 |
T494 |
T476 |
punct |
", ",use |
| R255 |
T495 |
T476 |
cc |
and,use |
| R256 |
T496 |
T497 |
advmod |
thus,are |
| R257 |
T497 |
T476 |
conj |
are,use |
| R258 |
T498 |
T499 |
npadvmod |
fatigue,resistant |
| R259 |
T499 |
T497 |
acomp |
resistant,are |
| R260 |
T500 |
T499 |
punct |
-,resistant |
| R261 |
T501 |
T470 |
punct |
.,are |
| R262 |
T503 |
T504 |
nmod |
Type,fibers |
| R263 |
T504 |
T506 |
nsubj |
fibers,comprise |
| R264 |
T505 |
T503 |
nummod |
II,Type |
| R265 |
T507 |
T508 |
nummod |
three,subtypes |
| R266 |
T508 |
T506 |
dobj |
subtypes,comprise |
| R267 |
T509 |
T508 |
punct |
", ",subtypes |
| R268 |
T510 |
T508 |
appos |
IIa,subtypes |
| R269 |
T511 |
T510 |
punct |
", ",IIa |
| R270 |
T512 |
T510 |
conj |
IIx,IIa |
| R271 |
T513 |
T512 |
punct |
", ",IIx |
| R272 |
T514 |
T512 |
cc |
and,IIx |
| R273 |
T515 |
T512 |
conj |
IIb,IIx |
| R274 |
T516 |
T506 |
punct |
.,comprise |
| R275 |
T518 |
T519 |
compound |
Type,IIb |
| R276 |
T519 |
T520 |
compound |
IIb,fibers |
| R277 |
T520 |
T521 |
nsubj |
fibers,have |
| R278 |
T522 |
T523 |
det |
the,levels |
| R279 |
T523 |
T521 |
dobj |
levels,have |
| R280 |
T524 |
T523 |
amod |
lowest,levels |
| R281 |
T525 |
T523 |
prep |
of,levels |
| R282 |
T526 |
T527 |
amod |
mitochondrial,content |
| R283 |
T527 |
T525 |
pobj |
content,of |
| R284 |
T528 |
T527 |
cc |
and,content |
| R285 |
T529 |
T530 |
amod |
oxidative,enzymes |
| R286 |
T530 |
T527 |
conj |
enzymes,content |
| R287 |
T531 |
T521 |
punct |
", ",have |
| R288 |
T532 |
T521 |
conj |
rely,have |
| R289 |
T533 |
T532 |
prep |
on,rely |
| R290 |
T534 |
T535 |
amod |
glycolytic,metabolism |
| R291 |
T535 |
T533 |
pobj |
metabolism,on |
| R292 |
T536 |
T532 |
prep |
as,rely |
| R293 |
T537 |
T538 |
det |
a,source |
| R294 |
T538 |
T536 |
pobj |
source,as |
| R295 |
T539 |
T538 |
amod |
major,source |
| R296 |
T540 |
T538 |
compound |
energy,source |
| R297 |
T541 |
T532 |
punct |
", ",rely |
| R298 |
T542 |
T532 |
cc |
and,rely |
| R299 |
T543 |
T532 |
conj |
are,rely |
| R300 |
T544 |
T543 |
acomp |
susceptible,are |
| R301 |
T545 |
T544 |
prep |
to,susceptible |
| R302 |
T546 |
T545 |
pobj |
fatigue,to |
| R303 |
T547 |
T521 |
punct |
", ",have |
| R304 |
T548 |
T549 |
mark |
while,lie |
| R305 |
T549 |
T521 |
advcl |
lie,have |
| R306 |
T550 |
T551 |
det |
the,functions |
| R307 |
T551 |
T549 |
nsubj |
functions,lie |
| R308 |
T552 |
T551 |
amod |
oxidative,functions |
| R309 |
T553 |
T552 |
cc |
and,oxidative |
| R310 |
T554 |
T552 |
conj |
contraction,oxidative |
| R311 |
T555 |
T551 |
prep |
of,functions |
| R312 |
T556 |
T557 |
compound |
type,IIa |
| R313 |
T557 |
T555 |
pobj |
IIa,of |
| R314 |
T558 |
T557 |
cc |
and,IIa |
| R315 |
T559 |
T557 |
conj |
IIx,IIa |
| R316 |
T560 |
T549 |
prep |
between,lie |
| R317 |
T561 |
T562 |
nmod |
type,IIb |
| R318 |
T562 |
T560 |
pobj |
IIb,between |
| R319 |
T563 |
T562 |
nummod |
I,IIb |
| R320 |
T564 |
T562 |
cc |
and,IIb |
| R321 |
T565 |
T566 |
punct |
(,Booth |
| R322 |
T566 |
T549 |
meta |
Booth,lie |
| R323 |
T567 |
T566 |
cc |
and,Booth |
| R324 |
T568 |
T566 |
conj |
Thomason,Booth |
| R325 |
T569 |
T568 |
nummod |
1991,Thomason |
| R326 |
T570 |
T568 |
punct |
;,Thomason |
| R327 |
T571 |
T568 |
conj |
Berchtold,Thomason |
| R328 |
T572 |
T571 |
nmod |
et,Berchtold |
| R329 |
T573 |
T571 |
nmod |
al.,Berchtold |
| R330 |
T574 |
T571 |
nummod |
2000,Berchtold |
| R331 |
T575 |
T571 |
punct |
;,Berchtold |
| R332 |
T576 |
T571 |
conj |
Olson,Berchtold |
| R333 |
T577 |
T576 |
cc |
and,Olson |
| R334 |
T578 |
T576 |
conj |
Williams,Olson |
| R335 |
T579 |
T578 |
nummod |
2000,Williams |
| R336 |
T580 |
T578 |
punct |
),Williams |
| R337 |
T581 |
T521 |
punct |
.,have |
| R338 |
T583 |
T584 |
amod |
Adult,muscle |
| R339 |
T584 |
T586 |
nsubj |
muscle,shows |
| R340 |
T585 |
T584 |
amod |
skeletal,muscle |
| R341 |
T587 |
T586 |
dobj |
plasticity,shows |
| R342 |
T588 |
T586 |
cc |
and,shows |
| R343 |
T589 |
T590 |
aux |
can,undergo |
| R344 |
T590 |
T586 |
conj |
undergo,shows |
| R345 |
T591 |
T590 |
dobj |
conversion,undergo |
| R346 |
T592 |
T591 |
prep |
between,conversion |
| R347 |
T593 |
T594 |
amod |
different,types |
| R348 |
T594 |
T592 |
pobj |
types,between |
| R349 |
T595 |
T594 |
compound |
fiber,types |
| R350 |
T596 |
T590 |
prep |
in,undergo |
| R351 |
T597 |
T596 |
pobj |
response,in |
| R352 |
T598 |
T597 |
prep |
to,response |
| R353 |
T599 |
T600 |
compound |
exercise,training |
| R354 |
T600 |
T598 |
pobj |
training,to |
| R355 |
T601 |
T600 |
cc |
or,training |
| R356 |
T602 |
T600 |
conj |
modulation,training |
| R357 |
T603 |
T602 |
prep |
of,modulation |
| R358 |
T604 |
T605 |
compound |
motoneuron,activity |
| R359 |
T605 |
T603 |
pobj |
activity,of |
| R360 |
T606 |
T607 |
punct |
(,Booth |
| R361 |
T607 |
T590 |
meta |
Booth,undergo |
| R362 |
T608 |
T607 |
cc |
and,Booth |
| R363 |
T609 |
T607 |
conj |
Thomason,Booth |
| R364 |
T610 |
T609 |
nummod |
1991,Thomason |
| R365 |
T611 |
T609 |
punct |
", ",Thomason |
| R366 |
T612 |
T609 |
conj |
Jarvis,Thomason |
| R367 |
T613 |
T612 |
nmod |
et,Jarvis |
| R368 |
T614 |
T612 |
nmod |
al.,Jarvis |
| R369 |
T615 |
T612 |
nummod |
1996,Jarvis |
| R370 |
T616 |
T612 |
punct |
;,Jarvis |
| R371 |
T617 |
T612 |
conj |
Pette,Jarvis |
| R372 |
T618 |
T617 |
nummod |
1998,Pette |
| R373 |
T619 |
T617 |
punct |
;,Pette |
| R374 |
T620 |
T617 |
conj |
Olson,Pette |
| R375 |
T621 |
T620 |
cc |
and,Olson |
| R376 |
T622 |
T620 |
conj |
Williams,Olson |
| R377 |
T623 |
T622 |
nummod |
2000,Williams |
| R378 |
T624 |
T622 |
punct |
;,Williams |
| R379 |
T625 |
T622 |
conj |
Hood,Williams |
| R380 |
T626 |
T625 |
nummod |
2001,Hood |
| R381 |
T627 |
T625 |
punct |
),Hood |
| R382 |
T628 |
T586 |
punct |
.,shows |
| R383 |
T630 |
T631 |
det |
This,conversion |
| R384 |
T631 |
T632 |
nsubj |
conversion,is |
| R385 |
T633 |
T631 |
prep |
of,conversion |
| R386 |
T634 |
T635 |
compound |
muscle,fiber |
| R387 |
T635 |
T633 |
pobj |
fiber,of |
| R388 |
T636 |
T631 |
prep |
from,conversion |
| R389 |
T637 |
T638 |
compound |
type,IIb |
| R390 |
T638 |
T636 |
pobj |
IIb,from |
| R391 |
T639 |
T631 |
prep |
to,conversion |
| R392 |
T640 |
T641 |
compound |
type,IIa |
| R393 |
T641 |
T639 |
pobj |
IIa,to |
| R394 |
T642 |
T641 |
cc |
and,IIa |
| R395 |
T643 |
T641 |
conj |
type,IIa |
| R396 |
T644 |
T643 |
nummod |
I,type |
| R397 |
T645 |
T632 |
acomp |
likely,is |
| R398 |
T646 |
T647 |
aux |
to,mediated |
| R399 |
T647 |
T645 |
xcomp |
mediated,likely |
| R400 |
T648 |
T647 |
auxpass |
be,mediated |
| R401 |
T649 |
T647 |
agent |
by,mediated |
| R402 |
T650 |
T651 |
det |
a,pathway |
| R403 |
T651 |
T649 |
pobj |
pathway,by |
| R404 |
T652 |
T651 |
compound |
calcium,pathway |
| R405 |
T653 |
T651 |
compound |
signaling,pathway |
| R406 |
T654 |
T655 |
dep |
that,involves |
| R407 |
T655 |
T651 |
relcl |
involves,pathway |
| R408 |
T656 |
T655 |
dobj |
calcineurin,involves |
| R409 |
T657 |
T656 |
punct |
", ",calcineurin |
| R410 |
T658 |
T659 |
npadvmod |
calmodulin,dependent |
| R411 |
T659 |
T661 |
amod |
dependent,kinase |
| R412 |
T660 |
T659 |
punct |
-,dependent |
| R413 |
T661 |
T656 |
conj |
kinase,calcineurin |
| R414 |
T662 |
T661 |
punct |
", ",kinase |
| R415 |
T663 |
T661 |
cc |
and,kinase |
| R416 |
T664 |
T665 |
det |
the,cofactor |
| R417 |
T665 |
T661 |
conj |
cofactor,kinase |
| R418 |
T666 |
T665 |
amod |
transcriptional,cofactor |
| R419 |
T667 |
T668 |
compound |
Peroxisome,proliferator |
| R420 |
T668 |
T669 |
npadvmod |
proliferator,activated |
| R421 |
T669 |
T671 |
amod |
activated,receptor |
| R422 |
T670 |
T669 |
punct |
-,activated |
| R423 |
T671 |
T672 |
compound |
receptor,coactivator |
| R424 |
T672 |
T665 |
appos |
coactivator,cofactor |
| R425 |
T673 |
T672 |
punct |
-,coactivator |
| R426 |
T674 |
T672 |
compound |
gamma,coactivator |
| R427 |
T675 |
T672 |
nummod |
1α,coactivator |
| R428 |
T676 |
T672 |
punct |
(,coactivator |
| R429 |
T677 |
T678 |
compound |
PGC,1α |
| R430 |
T678 |
T672 |
appos |
1α,coactivator |
| R431 |
T679 |
T678 |
punct |
-,1α |
| R432 |
T680 |
T672 |
punct |
),coactivator |
| R433 |
T681 |
T682 |
punct |
(,Naya |
| R434 |
T682 |
T655 |
meta |
Naya,involves |
| R435 |
T683 |
T682 |
nmod |
et,Naya |
| R436 |
T684 |
T682 |
nmod |
al.,Naya |
| R437 |
T685 |
T682 |
nummod |
2000,Naya |
| R438 |
T686 |
T682 |
punct |
;,Naya |
| R439 |
T687 |
T682 |
conj |
Olson,Naya |
| R440 |
T688 |
T687 |
cc |
and,Olson |
| R441 |
T689 |
T687 |
conj |
Williams,Olson |
| R442 |
T690 |
T689 |
nummod |
2000,Williams |
| R443 |
T691 |
T689 |
punct |
;,Williams |
| R444 |
T692 |
T689 |
conj |
Lin,Williams |
| R445 |
T693 |
T692 |
nmod |
et,Lin |
| R446 |
T694 |
T692 |
nmod |
al.,Lin |
| R447 |
T695 |
T692 |
nummod |
2002,Lin |
| R448 |
T696 |
T692 |
punct |
;,Lin |
| R449 |
T697 |
T692 |
conj |
Wu,Lin |
| R450 |
T698 |
T697 |
nmod |
et,Wu |
| R451 |
T699 |
T697 |
nmod |
al.,Wu |
| R452 |
T700 |
T697 |
nummod |
2002,Wu |
| R453 |
T701 |
T697 |
punct |
),Wu |
| R454 |
T702 |
T632 |
punct |
.,is |
| R455 |
T704 |
T705 |
advmod |
However,remain |
| R456 |
T706 |
T705 |
punct |
", ",remain |
| R457 |
T707 |
T708 |
det |
the,factors |
| R458 |
T708 |
T705 |
nsubj |
factors,remain |
| R459 |
T709 |
T708 |
amod |
targeted,factors |
| R460 |
T710 |
T708 |
amod |
transcriptional,factors |
| R461 |
T711 |
T712 |
advmod |
directly,responsible |
| R462 |
T712 |
T708 |
amod |
responsible,factors |
| R463 |
T713 |
T712 |
prep |
for,responsible |
| R464 |
T714 |
T713 |
pcomp |
reprogramming,for |
| R465 |
T715 |
T716 |
det |
the,genes |
| R466 |
T716 |
T714 |
dobj |
genes,reprogramming |
| R467 |
T717 |
T718 |
npadvmod |
fiber,specific |
| R468 |
T718 |
T716 |
amod |
specific,genes |
| R469 |
T719 |
T718 |
punct |
-,specific |
| R470 |
T720 |
T716 |
amod |
contractile,genes |
| R471 |
T721 |
T720 |
cc |
and,contractile |
| R472 |
T722 |
T720 |
conj |
metabolic,contractile |
| R473 |
T723 |
T724 |
aux |
to,identified |
| R474 |
T724 |
T705 |
xcomp |
identified,remain |
| R475 |
T725 |
T724 |
auxpass |
be,identified |
| R476 |
T726 |
T705 |
punct |
.,remain |
| R477 |
T728 |
T729 |
compound |
Muscle,specification |
| R478 |
T729 |
T731 |
nsubj |
specification,appears |
| R479 |
T730 |
T729 |
compound |
fiber,specification |
| R480 |
T732 |
T733 |
aux |
to,associated |
| R481 |
T733 |
T731 |
xcomp |
associated,appears |
| R482 |
T734 |
T733 |
auxpass |
be,associated |
| R483 |
T735 |
T733 |
prep |
with,associated |
| R484 |
T736 |
T735 |
pobj |
obesity,with |
| R485 |
T737 |
T736 |
cc |
and,obesity |
| R486 |
T738 |
T736 |
conj |
diabetes,obesity |
| R487 |
T739 |
T731 |
punct |
.,appears |
| R488 |
T741 |
T742 |
prep |
For,possess |
| R489 |
T743 |
T741 |
pobj |
instance,For |
| R490 |
T744 |
T742 |
punct |
", ",possess |
| R491 |
T745 |
T742 |
nsubj |
rodents,possess |
| R492 |
T746 |
T747 |
dep |
that,gain |
| R493 |
T747 |
T745 |
relcl |
gain,rodents |
| R494 |
T748 |
T749 |
det |
the,weight |
| R495 |
T749 |
T747 |
dobj |
weight,gain |
| R496 |
T750 |
T749 |
amod |
most,weight |
| R497 |
T751 |
T747 |
prep |
on,gain |
| R498 |
T752 |
T753 |
amod |
high,fat |
| R499 |
T753 |
T755 |
compound |
fat,diets |
| R500 |
T754 |
T753 |
punct |
-,fat |
| R501 |
T755 |
T751 |
pobj |
diets,on |
| R502 |
T756 |
T757 |
amod |
fewer,fibers |
| R503 |
T757 |
T742 |
dobj |
fibers,possess |
| R504 |
T758 |
T757 |
nmod |
type,fibers |
| R505 |
T759 |
T758 |
nummod |
I,type |
| R506 |
T760 |
T761 |
punct |
(,Abou |
| R507 |
T761 |
T742 |
meta |
Abou,possess |
| R508 |
T762 |
T761 |
nmod |
et,Abou |
| R509 |
T763 |
T761 |
nmod |
al.,Abou |
| R510 |
T764 |
T761 |
nummod |
1992,Abou |
| R511 |
T765 |
T761 |
punct |
),Abou |
| R512 |
T766 |
T742 |
punct |
.,possess |
| R513 |
T768 |
T769 |
prep |
In,observed |
| R514 |
T770 |
T771 |
amod |
obese,patients |
| R515 |
T771 |
T768 |
pobj |
patients,In |
| R516 |
T772 |
T769 |
punct |
", ",observed |
| R517 |
T773 |
T774 |
amod |
skeletal,muscle |
| R518 |
T774 |
T769 |
nsubjpass |
muscle,observed |
| R519 |
T775 |
T769 |
aux |
has,observed |
| R520 |
T776 |
T769 |
auxpass |
been,observed |
| R521 |
T777 |
T778 |
aux |
to,have |
| R522 |
T778 |
T769 |
xcomp |
have,observed |
| R523 |
T779 |
T780 |
amod |
reduced,capacity |
| R524 |
T780 |
T778 |
dobj |
capacity,have |
| R525 |
T781 |
T780 |
amod |
oxidative,capacity |
| R526 |
T782 |
T780 |
punct |
", ",capacity |
| R527 |
T783 |
T784 |
amod |
increased,capacity |
| R528 |
T784 |
T780 |
conj |
capacity,capacity |
| R529 |
T785 |
T784 |
amod |
glycolytic,capacity |
| R530 |
T786 |
T784 |
punct |
", ",capacity |
| R531 |
T787 |
T784 |
cc |
and,capacity |
| R532 |
T788 |
T789 |
det |
a,percentage |
| R533 |
T789 |
T784 |
conj |
percentage,capacity |
| R534 |
T790 |
T789 |
amod |
decreased,percentage |
| R535 |
T791 |
T789 |
prep |
of,percentage |
| R536 |
T792 |
T793 |
nmod |
type,fibers |
| R537 |
T793 |
T791 |
pobj |
fibers,of |
| R538 |
T794 |
T792 |
nummod |
I,type |
| R539 |
T795 |
T796 |
punct |
(,Hickey |
| R540 |
T796 |
T769 |
meta |
Hickey,observed |
| R541 |
T797 |
T796 |
nmod |
et,Hickey |
| R542 |
T798 |
T796 |
nmod |
al.,Hickey |
| R543 |
T799 |
T796 |
nummod |
1995,Hickey |
| R544 |
T800 |
T796 |
punct |
;,Hickey |
| R545 |
T801 |
T796 |
nmod |
Tanner,Hickey |
| R546 |
T802 |
T796 |
nmod |
et,Hickey |
| R547 |
T803 |
T796 |
nmod |
al.,Hickey |
| R548 |
T804 |
T796 |
nummod |
2002,Hickey |
| R549 |
T805 |
T796 |
punct |
),Hickey |
| R550 |
T806 |
T769 |
punct |
.,observed |
| R551 |
T808 |
T809 |
amod |
Similar,observations |
| R552 |
T809 |
T810 |
nsubjpass |
observations,made |
| R553 |
T811 |
T810 |
aux |
have,made |
| R554 |
T812 |
T810 |
auxpass |
been,made |
| R555 |
T813 |
T810 |
prep |
in,made |
| R556 |
T814 |
T815 |
npadvmod |
type,diabetic |
| R557 |
T815 |
T817 |
amod |
diabetic,patients |
| R558 |
T816 |
T814 |
nummod |
2,type |
| R559 |
T817 |
T813 |
pobj |
patients,in |
| R560 |
T818 |
T819 |
punct |
(,Lillioja |
| R561 |
T819 |
T810 |
meta |
Lillioja,made |
| R562 |
T820 |
T819 |
nmod |
et,Lillioja |
| R563 |
T821 |
T819 |
nmod |
al.,Lillioja |
| R564 |
T822 |
T819 |
nummod |
1987,Lillioja |
| R565 |
T823 |
T819 |
punct |
;,Lillioja |
| R566 |
T824 |
T819 |
nmod |
Hickey,Lillioja |
| R567 |
T825 |
T819 |
nmod |
et,Lillioja |
| R568 |
T826 |
T819 |
nmod |
al.,Lillioja |
| R569 |
T827 |
T819 |
nummod |
1995,Lillioja |
| R570 |
T828 |
T819 |
punct |
),Lillioja |
| R571 |
T829 |
T810 |
punct |
.,made |
| R572 |
T831 |
T832 |
advmod |
Recently,shown |
| R573 |
T833 |
T832 |
punct |
", ",shown |
| R574 |
T834 |
T832 |
nsubjpass |
it,shown |
| R575 |
T835 |
T832 |
aux |
has,shown |
| R576 |
T836 |
T832 |
auxpass |
been,shown |
| R577 |
T837 |
T838 |
mark |
that,lead |
| R578 |
T838 |
T832 |
ccomp |
lead,shown |
| R579 |
T839 |
T840 |
amod |
increasing,fibers |
| R580 |
T840 |
T838 |
nsubj |
fibers,lead |
| R581 |
T841 |
T840 |
amod |
oxidative,fibers |
| R582 |
T842 |
T838 |
aux |
can,lead |
| R583 |
T843 |
T838 |
prep |
to,lead |
| R584 |
T844 |
T845 |
amod |
improved,action |
| R585 |
T845 |
T843 |
pobj |
action,to |
| R586 |
T846 |
T845 |
compound |
insulin,action |
| R587 |
T847 |
T845 |
cc |
and,action |
| R588 |
T848 |
T849 |
amod |
reduced,size |
| R589 |
T849 |
T845 |
conj |
size,action |
| R590 |
T850 |
T849 |
compound |
adipocyte,size |
| R591 |
T851 |
T852 |
punct |
(,Luquet |
| R592 |
T852 |
T832 |
meta |
Luquet,shown |
| R593 |
T853 |
T852 |
nmod |
et,Luquet |
| R594 |
T854 |
T852 |
nmod |
al.,Luquet |
| R595 |
T855 |
T852 |
nummod |
2003,Luquet |
| R596 |
T856 |
T852 |
punct |
;,Luquet |
| R597 |
T857 |
T852 |
nmod |
Ryder,Luquet |
| R598 |
T858 |
T852 |
nmod |
et,Luquet |
| R599 |
T859 |
T852 |
nmod |
al.,Luquet |
| R600 |
T860 |
T852 |
nummod |
2003,Luquet |
| R601 |
T861 |
T852 |
punct |
),Luquet |
| R602 |
T862 |
T832 |
punct |
.,shown |
| R603 |
T864 |
T865 |
nsubj |
We,established |
| R604 |
T866 |
T865 |
aux |
have,established |
| R605 |
T867 |
T865 |
advmod |
previously,established |
| R606 |
T868 |
T869 |
mark |
that,is |
| R607 |
T869 |
T865 |
ccomp |
is,established |
| R608 |
T870 |
T871 |
compound |
peroxisome,proliferator |
| R609 |
T871 |
T872 |
npadvmod |
proliferator,activated |
| R610 |
T872 |
T874 |
amod |
activated,receptor |
| R611 |
T873 |
T872 |
punct |
-,activated |
| R612 |
T874 |
T869 |
nsubj |
receptor,is |
| R613 |
T875 |
T874 |
punct |
(,receptor |
| R614 |
T876 |
T874 |
appos |
PPAR,receptor |
| R615 |
T877 |
T874 |
punct |
),receptor |
| R616 |
T878 |
T874 |
punct |
δ,receptor |
| R617 |
T879 |
T880 |
det |
a,regulator |
| R618 |
T880 |
T869 |
attr |
regulator,is |
| R619 |
T881 |
T880 |
amod |
major,regulator |
| R620 |
T882 |
T880 |
amod |
transcriptional,regulator |
| R621 |
T883 |
T880 |
prep |
of,regulator |
| R622 |
T884 |
T885 |
compound |
fat,burning |
| R623 |
T885 |
T883 |
pobj |
burning,of |
| R624 |
T886 |
T869 |
prep |
in,is |
| R625 |
T887 |
T888 |
compound |
adipose,tissue |
| R626 |
T888 |
T886 |
pobj |
tissue,in |
| R627 |
T889 |
T869 |
prep |
through,is |
| R628 |
T890 |
T889 |
pobj |
activation,through |
| R629 |
T891 |
T890 |
prep |
of,activation |
| R630 |
T892 |
T891 |
pobj |
enzymes,of |
| R631 |
T893 |
T892 |
acl |
associated,enzymes |
| R632 |
T894 |
T893 |
prep |
with,associated |
| R633 |
T895 |
T896 |
amod |
long,chain |
| R634 |
T896 |
T898 |
nmod |
chain,oxidation |
| R635 |
T897 |
T896 |
punct |
-,chain |
| R636 |
T898 |
T894 |
pobj |
oxidation,with |
| R637 |
T899 |
T900 |
amod |
fatty,acid |
| R638 |
T900 |
T898 |
compound |
acid,oxidation |
| R639 |
T901 |
T900 |
punct |
-,acid |
| R640 |
T902 |
T898 |
compound |
β,oxidation |
| R641 |
T903 |
T898 |
punct |
-,oxidation |
| R642 |
T904 |
T905 |
punct |
(,Wang |
| R643 |
T905 |
T865 |
meta |
Wang,established |
| R644 |
T906 |
T905 |
nmod |
et,Wang |
| R645 |
T907 |
T905 |
nmod |
al.,Wang |
| R646 |
T908 |
T905 |
nummod |
2003,Wang |
| R647 |
T909 |
T905 |
punct |
),Wang |
| R648 |
T910 |
T865 |
punct |
.,established |
| R649 |
T912 |
T913 |
mark |
Although,is |
| R650 |
T913 |
T915 |
advcl |
is,determined |
| R651 |
T914 |
T913 |
nsubj |
PPARδ,is |
| R652 |
T916 |
T917 |
det |
the,isoform |
| R653 |
T917 |
T913 |
attr |
isoform,is |
| R654 |
T918 |
T917 |
amod |
predominant,isoform |
| R655 |
T919 |
T917 |
compound |
PPAR,isoform |
| R656 |
T920 |
T917 |
amod |
present,isoform |
| R657 |
T921 |
T920 |
prep |
in,present |
| R658 |
T922 |
T923 |
amod |
skeletal,muscle |
| R659 |
T923 |
T921 |
pobj |
muscle,in |
| R660 |
T924 |
T915 |
punct |
", ",determined |
| R661 |
T925 |
T926 |
poss |
its,function |
| R662 |
T926 |
T915 |
nsubjpass |
function,determined |
| R663 |
T927 |
T928 |
nmod |
in,vivo |
| R664 |
T928 |
T926 |
nmod |
vivo,function |
| R665 |
T929 |
T915 |
aux |
has,determined |
| R666 |
T930 |
T915 |
neg |
not,determined |
| R667 |
T931 |
T915 |
auxpass |
been,determined |
| R668 |
T932 |
T915 |
punct |
.,determined |
| R669 |
T934 |
T935 |
poss |
Our,study |
| R670 |
T935 |
T937 |
nsubj |
study,uncovers |
| R671 |
T936 |
T935 |
amod |
current,study |
| R672 |
T938 |
T937 |
dobj |
PPARδ,uncovers |
| R673 |
T939 |
T937 |
prep |
as,uncovers |
| R674 |
T940 |
T941 |
det |
the,factor |
| R675 |
T941 |
T939 |
pobj |
factor,as |
| R676 |
T942 |
T941 |
amod |
first,factor |
| R677 |
T943 |
T941 |
compound |
transcription,factor |
| R678 |
T944 |
T941 |
amod |
able,factor |
| R679 |
T945 |
T946 |
aux |
to,drive |
| R680 |
T946 |
T944 |
xcomp |
drive,able |
| R681 |
T947 |
T948 |
det |
the,formation |
| R682 |
T948 |
T946 |
dobj |
formation,drive |
| R683 |
T949 |
T948 |
prep |
of,formation |
| R684 |
T950 |
T951 |
amod |
functional,fibers |
| R685 |
T951 |
T949 |
pobj |
fibers,of |
| R686 |
T952 |
T951 |
nmod |
type,fibers |
| R687 |
T953 |
T952 |
nummod |
I,type |
| R688 |
T954 |
T951 |
compound |
muscle,fibers |
| R689 |
T955 |
T941 |
punct |
", ",factor |
| R690 |
T956 |
T957 |
poss |
whose,activation |
| R691 |
T957 |
T958 |
dep |
activation,entrains |
| R692 |
T958 |
T941 |
relcl |
entrains,factor |
| R693 |
T959 |
T960 |
amod |
complex,pathways |
| R694 |
T960 |
T958 |
dobj |
pathways,entrains |
| R695 |
T961 |
T962 |
preconj |
both,enhancing |
| R696 |
T962 |
T960 |
acl |
enhancing,pathways |
| R697 |
T963 |
T964 |
amod |
physical,performance |
| R698 |
T964 |
T962 |
dobj |
performance,enhancing |
| R699 |
T965 |
T962 |
cc |
and,enhancing |
| R700 |
T966 |
T962 |
conj |
creating,enhancing |
| R701 |
T967 |
T968 |
det |
a,state |
| R702 |
T968 |
T966 |
dobj |
state,creating |
| R703 |
T969 |
T968 |
prep |
of,state |
| R704 |
T970 |
T971 |
compound |
obesity,resistance |
| R705 |
T971 |
T969 |
pobj |
resistance,of |
| R706 |
T972 |
T937 |
punct |
.,uncovers |
