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PMC:340383 / 14381-16609 JSONTXT 5 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T3529 11-19 IN denotes Although
T3531 20-23 DT denotes the
T3533 24-29 JJ denotes exact
T3532 30-39 NNS denotes functions
T3534 40-42 IN denotes of
T3535 43-46 DT denotes the
T3537 47-51 NN denotes ACDP
T3538 52-56 NN denotes gene
T3536 57-63 NN denotes family
T3539 64-67 VBP denotes are
T3540 68-71 RB denotes not
T3541 72-75 RB denotes yet
T3530 76-86 VBN denotes elucidated
T3543 86-88 , denotes ,
T3544 88-95 JJ denotes several
T3545 96-101 NNS denotes lines
T3546 102-104 IN denotes of
T3547 105-113 NN denotes evidence
T3542 114-121 VBP denotes suggest
T3548 122-126 IN denotes that
T3550 127-131 NN denotes ACDP
T3551 132-137 NNS denotes genes
T3552 138-141 MD denotes may
T3549 142-146 VB denotes play
T3553 147-149 DT denotes an
T3555 150-159 JJ denotes important
T3554 160-164 NN denotes role
T3556 165-167 IN denotes in
T3557 168-178 JJ denotes biological
T3558 179-188 NNS denotes processes
T3559 188-189 . denotes .
T3560 189-437 sentence denotes First, these genes are evolutionarily conserved in many phylogenetically divergent species; Second, multiple genes are present in a species; Third, these genes are ubiquitously expressed throughout development and adult tissues (unpublished data).
T3561 190-195 RB denotes First
T3563 195-197 , denotes ,
T3564 197-202 DT denotes these
T3565 203-208 NNS denotes genes
T3566 209-212 VBP denotes are
T3567 213-227 RB denotes evolutionarily
T3562 228-237 VBN denotes conserved
T3569 238-240 IN denotes in
T3570 241-245 JJ denotes many
T3572 246-262 RB denotes phylogenetically
T3573 263-272 JJ denotes divergent
T3571 273-280 NNS denotes species
T3574 280-281 : denotes ;
T3575 282-288 RB denotes Second
T3577 288-290 , denotes ,
T3578 290-298 JJ denotes multiple
T3579 299-304 NNS denotes genes
T3576 305-308 VBP denotes are
T3580 309-316 JJ denotes present
T3581 317-319 IN denotes in
T3582 320-321 DT denotes a
T3583 322-329 NN denotes species
T3584 329-330 : denotes ;
T3585 331-336 RB denotes Third
T3586 336-338 , denotes ,
T3587 338-343 DT denotes these
T3588 344-349 NNS denotes genes
T3589 350-353 VBP denotes are
T3590 354-366 RB denotes ubiquitously
T3568 367-376 VBN denotes expressed
T3591 377-387 IN denotes throughout
T3592 388-399 NN denotes development
T3594 400-403 CC denotes and
T3595 404-409 JJ denotes adult
T3593 410-417 NNS denotes tissues
T3596 418-419 -LRB- denotes (
T3598 419-430 JJ denotes unpublished
T3597 431-435 NNS denotes data
T3599 435-436 -RRB- denotes )
T3600 436-437 . denotes .
T3601 437-593 sentence denotes The cloning and characterization of the mouse Acdp gene family are a very important step towards the elucidation of the functions of this multigene family.
T3602 438-441 DT denotes The
T3603 442-449 NN denotes cloning
T3605 450-453 CC denotes and
T3606 454-470 NN denotes characterization
T3607 471-473 IN denotes of
T3608 474-477 DT denotes the
T3610 478-483 NN denotes mouse
T3611 484-488 NN denotes Acdp
T3612 489-493 NN denotes gene
T3609 494-500 NN denotes family
T3604 501-504 VBP denotes are
T3613 505-506 DT denotes a
T3615 507-511 RB denotes very
T3616 512-521 JJ denotes important
T3614 522-526 NN denotes step
T3617 527-534 IN denotes towards
T3618 535-538 DT denotes the
T3619 539-550 NN denotes elucidation
T3620 551-553 IN denotes of
T3621 554-557 DT denotes the
T3622 558-567 NNS denotes functions
T3623 568-570 IN denotes of
T3624 571-575 DT denotes this
T3626 576-585 JJ denotes multigene
T3625 586-592 NN denotes family
T3627 592-593 . denotes .
T3628 593-735 sentence denotes Sequence homology analyses revealed that Acdp proteins shared very strong AA homologies to the bacteria CorC protein and yeast Amip3 protein.
T3629 594-602 NN denotes Sequence
T3631 603-611 NN denotes homology
T3630 612-620 NNS denotes analyses
T3632 621-629 VBD denotes revealed
T3633 630-634 IN denotes that
T3635 635-639 NN denotes Acdp
T3636 640-648 NN denotes proteins
T3634 649-655 VBD denotes shared
T3637 656-660 RB denotes very
T3638 661-667 JJ denotes strong
T3640 668-670 NN denotes AA
T3639 671-681 NNS denotes homologies
T3641 682-684 IN denotes to
T3642 685-688 DT denotes the
T3644 689-697 NNS denotes bacteria
T3645 698-702 NN denotes CorC
T3643 703-710 NN denotes protein
T3646 711-714 CC denotes and
T3647 715-720 NN denotes yeast
T3649 721-726 NN denotes Amip3
T3648 727-734 NN denotes protein
T3650 734-735 . denotes .
T3651 735-839 sentence denotes CorA, B, C and D belong to a protein family involved in both influx and efflux of magnesium and cobalt.
T3652 736-740 NN denotes CorA
T3654 740-742 , denotes ,
T3655 742-743 NN denotes B
T3656 743-745 , denotes ,
T3657 745-746 NN denotes C
T3658 747-750 CC denotes and
T3659 751-752 NN denotes D
T3653 753-759 VBP denotes belong
T3660 760-762 IN denotes to
T3661 763-764 DT denotes a
T3663 765-772 NN denotes protein
T3662 773-779 NN denotes family
T3664 780-788 VBN denotes involved
T3665 789-791 IN denotes in
T3666 792-796 CC denotes both
T3667 797-803 NN denotes influx
T3668 804-807 CC denotes and
T3669 808-814 NN denotes efflux
T3670 815-817 IN denotes of
T3671 818-827 NN denotes magnesium
T3672 828-831 CC denotes and
T3673 832-838 NN denotes cobalt
T3674 838-839 . denotes .
T3675 839-917 sentence denotes It has been shown that CorA mutants confer resistance to cobalt toxicity [9].
T3676 840-842 PRP denotes It
T3678 843-846 VBZ denotes has
T3679 847-851 VBN denotes been
T3677 852-857 VBN denotes shown
T3680 858-862 IN denotes that
T3682 863-867 NN denotes CorA
T3683 868-875 NNS denotes mutants
T3681 876-882 VBP denotes confer
T3684 883-893 NN denotes resistance
T3685 894-896 IN denotes to
T3686 897-903 NN denotes cobalt
T3687 904-912 NN denotes toxicity
T3688 913-914 -LRB- denotes [
T3689 914-915 CD denotes 9
T3690 915-916 -RRB- denotes ]
T3691 916-917 . denotes .
T3692 917-1031 sentence denotes Amip3 appears to be a homologous to CorC protein which is involved in efflux of magnesium and cobalt in bacteria.
T3693 918-923 NN denotes Amip3
T3694 924-931 VBZ denotes appears
T3695 932-934 TO denotes to
T3696 935-937 VB denotes be
T3697 938-939 DT denotes a
T3698 940-950 JJ denotes homologous
T3699 951-953 IN denotes to
T3700 954-958 NN denotes CorC
T3701 959-966 NN denotes protein
T3702 967-972 WDT denotes which
T3704 973-975 VBZ denotes is
T3703 976-984 VBN denotes involved
T3705 985-987 IN denotes in
T3706 988-994 NN denotes efflux
T3707 995-997 IN denotes of
T3708 998-1007 NN denotes magnesium
T3709 1008-1011 CC denotes and
T3710 1012-1018 NN denotes cobalt
T3711 1019-1021 IN denotes in
T3712 1022-1030 NNS denotes bacteria
T3713 1030-1031 . denotes .
T3714 1031-1082 sentence denotes Amip3 mutants confer resistant to copper toxicity.
T3715 1032-1037 NN denotes Amip3
T3716 1038-1045 NNS denotes mutants
T3717 1046-1052 VBP denotes confer
T3718 1053-1062 NN denotes resistant
T3719 1063-1065 IN denotes to
T3720 1066-1072 NN denotes copper
T3721 1073-1081 NN denotes toxicity
T3722 1081-1082 . denotes .
T3723 1082-1244 sentence denotes Acdp proteins also possess the domains that are found in bacteria CorC and yeast Amip3 proteins, such as the CBS domains, DUF21 domain and transmembrane domains.
T3724 1083-1087 NN denotes Acdp
T3726 1088-1096 NN denotes proteins
T3727 1097-1101 RB denotes also
T3725 1102-1109 VBP denotes possess
T3728 1110-1113 DT denotes the
T3729 1114-1121 NNS denotes domains
T3730 1122-1126 WDT denotes that
T3732 1127-1130 VBP denotes are
T3731 1131-1136 VBN denotes found
T3733 1137-1139 IN denotes in
T3734 1140-1148 NNS denotes bacteria
T3735 1149-1153 NN denotes CorC
T3737 1154-1157 CC denotes and
T3738 1158-1163 NN denotes yeast
T3739 1164-1169 NN denotes Amip3
T3736 1170-1178 NN denotes proteins
T3740 1178-1180 , denotes ,
T3741 1180-1184 JJ denotes such
T3742 1185-1187 IN denotes as
T3743 1188-1191 DT denotes the
T3745 1192-1195 NN denotes CBS
T3744 1196-1203 NNS denotes domains
T3746 1203-1205 , denotes ,
T3747 1205-1210 NN denotes DUF21
T3748 1211-1217 NN denotes domain
T3749 1218-1221 CC denotes and
T3750 1222-1235 NN denotes transmembrane
T3751 1236-1243 NNS denotes domains
T3752 1243-1244 . denotes .
T3753 1244-1388 sentence denotes In addition, a cNMP-binding domain was found in all Acdp proteins, which is usually present in ion channels and cNMP-dependent kinases [10-13].
T3754 1245-1247 IN denotes In
T3756 1248-1256 NN denotes addition
T3757 1256-1258 , denotes ,
T3758 1258-1259 DT denotes a
T3760 1260-1264 NN denotes cNMP
T3762 1264-1265 HYPH denotes -
T3761 1265-1272 VBG denotes binding
T3759 1273-1279 NN denotes domain
T3763 1280-1283 VBD denotes was
T3755 1284-1289 VBN denotes found
T3764 1290-1292 IN denotes in
T3765 1293-1296 DT denotes all
T3767 1297-1301 NN denotes Acdp
T3766 1302-1310 NN denotes proteins
T3768 1310-1312 , denotes ,
T3769 1312-1317 WDT denotes which
T3770 1318-1320 VBZ denotes is
T3771 1321-1328 RB denotes usually
T3772 1329-1336 JJ denotes present
T3773 1337-1339 IN denotes in
T3774 1340-1343 NN denotes ion
T3775 1344-1352 NNS denotes channels
T3776 1353-1356 CC denotes and
T3777 1357-1361 NN denotes cNMP
T3779 1361-1362 HYPH denotes -
T3780 1362-1371 JJ denotes dependent
T3778 1372-1379 NNS denotes kinases
T3781 1380-1381 -LRB- denotes [
T3782 1381-1383 CD denotes 10
T3783 1383-1384 SYM denotes -
T3784 1384-1386 CD denotes 13
T3785 1386-1387 -RRB- denotes ]
T3786 1387-1388 . denotes .
T3787 1388-1540 sentence denotes Using antibody produced by Acdp1 C-terminal peptide, we have shown that Acdp1 is predominantly localized on the plasma membrane in hippocampus neurons.
T3788 1389-1394 VBG denotes Using
T3790 1395-1403 NN denotes antibody
T3791 1404-1412 VBN denotes produced
T3792 1413-1415 IN denotes by
T3793 1416-1421 NN denotes Acdp1
T3795 1422-1423 NN denotes C
T3797 1423-1424 HYPH denotes -
T3796 1424-1432 JJ denotes terminal
T3794 1433-1440 NN denotes peptide
T3798 1440-1442 , denotes ,
T3799 1442-1444 PRP denotes we
T3800 1445-1449 VBP denotes have
T3789 1450-1455 VBN denotes shown
T3801 1456-1460 IN denotes that
T3803 1461-1466 NN denotes Acdp1
T3804 1467-1469 VBZ denotes is
T3805 1470-1483 RB denotes predominantly
T3802 1484-1493 VBN denotes localized
T3806 1494-1496 IN denotes on
T3807 1497-1500 DT denotes the
T3809 1501-1507 NN denotes plasma
T3808 1508-1516 NN denotes membrane
T3810 1517-1519 IN denotes in
T3811 1520-1531 NN denotes hippocampus
T3812 1532-1539 NNS denotes neurons
T3813 1539-1540 . denotes .
T3814 1540-1654 sentence denotes In our previous study, we found human ACDP proteins are predominantly localized in the nucleus in HeLa cells [1].
T3815 1541-1543 IN denotes In
T3817 1544-1547 PRP$ denotes our
T3819 1548-1556 JJ denotes previous
T3818 1557-1562 NN denotes study
T3820 1562-1564 , denotes ,
T3821 1564-1566 PRP denotes we
T3816 1567-1572 VBD denotes found
T3822 1573-1578 JJ denotes human
T3824 1579-1583 NN denotes ACDP
T3823 1584-1592 NN denotes proteins
T3826 1593-1596 VBP denotes are
T3827 1597-1610 RB denotes predominantly
T3825 1611-1620 VBN denotes localized
T3828 1621-1623 IN denotes in
T3829 1624-1627 DT denotes the
T3830 1628-1635 NN denotes nucleus
T3831 1636-1638 IN denotes in
T3832 1639-1643 NN denotes HeLa
T3833 1644-1649 NNS denotes cells
T3834 1650-1651 -LRB- denotes [
T3835 1651-1652 CD denotes 1
T3836 1652-1653 -RRB- denotes ]
T3837 1653-1654 . denotes .
T3838 1654-1842 sentence denotes The discrepancy for Acdp localization in neuronal cells could be caused by non-specificity for previous antibody which was produced by the recombinant ACD domain, or different cells used.
T3839 1655-1658 DT denotes The
T3840 1659-1670 NN denotes discrepancy
T3842 1671-1674 IN denotes for
T3843 1675-1679 NN denotes Acdp
T3844 1680-1692 NN denotes localization
T3845 1693-1695 IN denotes in
T3846 1696-1704 JJ denotes neuronal
T3847 1705-1710 NNS denotes cells
T3848 1711-1716 MD denotes could
T3849 1717-1719 VB denotes be
T3841 1720-1726 VBN denotes caused
T3850 1727-1729 IN denotes by
T3851 1730-1745 NN denotes non-specificity
T3852 1746-1749 IN denotes for
T3853 1750-1758 JJ denotes previous
T3854 1759-1767 NN denotes antibody
T3855 1768-1773 WDT denotes which
T3857 1774-1777 VBD denotes was
T3856 1778-1786 VBN denotes produced
T3858 1787-1789 IN denotes by
T3859 1790-1793 DT denotes the
T3861 1794-1805 JJ denotes recombinant
T3862 1806-1809 NN denotes ACD
T3860 1810-1816 NN denotes domain
T3863 1816-1818 , denotes ,
T3864 1818-1820 CC denotes or
T3865 1821-1830 JJ denotes different
T3866 1831-1836 NNS denotes cells
T3867 1837-1841 VBN denotes used
T3868 1841-1842 . denotes .
T3869 1842-2030 sentence denotes In current study, the Acdp1 C-terminus antibody only recognizes Acdp1 in brain tissue extracts as well as in HEK293, 3T3 and PC12 cell lysates, suggesting the specificity of the antibody.
T3870 1843-1845 IN denotes In
T3872 1846-1853 JJ denotes current
T3873 1854-1859 NN denotes study
T3874 1859-1861 , denotes ,
T3875 1861-1864 DT denotes the
T3877 1865-1870 NN denotes Acdp1
T3878 1871-1872 NN denotes C
T3880 1872-1873 HYPH denotes -
T3879 1873-1881 NN denotes terminus
T3876 1882-1890 NN denotes antibody
T3881 1891-1895 RB denotes only
T3871 1896-1906 VBZ denotes recognizes
T3882 1907-1912 NN denotes Acdp1
T3883 1913-1915 IN denotes in
T3884 1916-1921 NN denotes brain
T3885 1922-1928 NN denotes tissue
T3886 1929-1937 NNS denotes extracts
T3887 1938-1940 RB denotes as
T3889 1941-1945 RB denotes well
T3888 1946-1948 IN denotes as
T3890 1949-1951 IN denotes in
T3891 1952-1958 NN denotes HEK293
T3893 1958-1960 , denotes ,
T3894 1960-1963 NN denotes 3T3
T3895 1964-1967 CC denotes and
T3896 1968-1972 NN denotes PC12
T3897 1973-1977 NN denotes cell
T3892 1978-1985 NNS denotes lysates
T3898 1985-1987 , denotes ,
T3899 1987-1997 VBG denotes suggesting
T3900 1998-2001 DT denotes the
T3901 2002-2013 NN denotes specificity
T3902 2014-2016 IN denotes of
T3903 2017-2020 DT denotes the
T3904 2021-2029 NN denotes antibody
T3905 2029-2030 . denotes .
T3906 2030-2122 sentence denotes Our observations suggested that Acdp might be involved in ion transport in mammalian cells.
T3907 2031-2034 PRP$ denotes Our
T3908 2035-2047 NNS denotes observations
T3909 2048-2057 VBD denotes suggested
T3910 2058-2062 IN denotes that
T3912 2063-2067 NN denotes Acdp
T3913 2068-2073 MD denotes might
T3914 2074-2076 VB denotes be
T3911 2077-2085 VBN denotes involved
T3915 2086-2088 IN denotes in
T3916 2089-2092 NN denotes ion
T3917 2093-2102 NN denotes transport
T3918 2103-2105 IN denotes in
T3919 2106-2115 JJ denotes mammalian
T3920 2116-2121 NNS denotes cells
T3921 2121-2122 . denotes .
T3922 2122-2228 sentence denotes However, more detailed functional studies are needed to demonstrate the real functions of these proteins.
T3923 2123-2130 RB denotes However
T3925 2130-2132 , denotes ,
T3926 2132-2136 RBR denotes more
T3927 2137-2145 JJ denotes detailed
T3929 2146-2156 JJ denotes functional
T3928 2157-2164 NNS denotes studies
T3930 2165-2168 VBP denotes are
T3924 2169-2175 VBN denotes needed
T3931 2176-2178 TO denotes to
T3932 2179-2190 VB denotes demonstrate
T3933 2191-2194 DT denotes the
T3935 2195-2199 JJ denotes real
T3934 2200-2209 NNS denotes functions
T3936 2210-2212 IN denotes of
T3937 2213-2218 DT denotes these
T3938 2219-2227 NN denotes proteins
T3939 2227-2228 . denotes .
R1973 T3529 T3530 mark Although,elucidated
R1974 T3530 T3542 advcl elucidated,suggest
R1975 T3531 T3532 det the,functions
R1976 T3532 T3530 nsubjpass functions,elucidated
R1977 T3533 T3532 amod exact,functions
R1978 T3534 T3532 prep of,functions
R1979 T3535 T3536 det the,family
R1980 T3536 T3534 pobj family,of
R1981 T3537 T3536 compound ACDP,family
R1982 T3538 T3536 compound gene,family
R1983 T3539 T3530 auxpass are,elucidated
R1984 T3540 T3530 neg not,elucidated
R1985 T3541 T3530 advmod yet,elucidated
R1986 T3543 T3542 punct ", ",suggest
R1987 T3544 T3545 amod several,lines
R1988 T3545 T3542 nsubj lines,suggest
R1989 T3546 T3545 prep of,lines
R1990 T3547 T3546 pobj evidence,of
R1991 T3548 T3549 mark that,play
R1992 T3549 T3542 ccomp play,suggest
R1993 T3550 T3551 compound ACDP,genes
R1994 T3551 T3549 nsubj genes,play
R1995 T3552 T3549 aux may,play
R1996 T3553 T3554 det an,role
R1997 T3554 T3549 dobj role,play
R1998 T3555 T3554 amod important,role
R1999 T3556 T3549 prep in,play
R2000 T3557 T3558 amod biological,processes
R2001 T3558 T3556 pobj processes,in
R2002 T3559 T3542 punct .,suggest
R2003 T3561 T3562 advmod First,conserved
R2004 T3562 T3568 ccomp conserved,expressed
R2005 T3563 T3562 punct ", ",conserved
R2006 T3564 T3565 det these,genes
R2007 T3565 T3562 nsubjpass genes,conserved
R2008 T3566 T3562 auxpass are,conserved
R2009 T3567 T3562 advmod evolutionarily,conserved
R2010 T3569 T3562 prep in,conserved
R2011 T3570 T3571 amod many,species
R2012 T3571 T3569 pobj species,in
R2013 T3572 T3573 advmod phylogenetically,divergent
R2014 T3573 T3571 amod divergent,species
R2015 T3574 T3568 punct ;,expressed
R2016 T3575 T3576 advmod Second,are
R2017 T3576 T3568 ccomp are,expressed
R2018 T3577 T3576 punct ", ",are
R2019 T3578 T3579 amod multiple,genes
R2020 T3579 T3576 nsubj genes,are
R2021 T3580 T3576 acomp present,are
R2022 T3581 T3576 prep in,are
R2023 T3582 T3583 det a,species
R2024 T3583 T3581 pobj species,in
R2025 T3584 T3568 punct ;,expressed
R2026 T3585 T3568 advmod Third,expressed
R2027 T3586 T3568 punct ", ",expressed
R2028 T3587 T3588 det these,genes
R2029 T3588 T3568 nsubjpass genes,expressed
R2030 T3589 T3568 auxpass are,expressed
R2031 T3590 T3568 advmod ubiquitously,expressed
R2032 T3591 T3568 prep throughout,expressed
R2033 T3592 T3593 nmod development,tissues
R2034 T3593 T3591 pobj tissues,throughout
R2035 T3594 T3592 cc and,development
R2036 T3595 T3592 conj adult,development
R2037 T3596 T3597 punct (,data
R2038 T3597 T3568 meta data,expressed
R2039 T3598 T3597 amod unpublished,data
R2040 T3599 T3597 punct ),data
R2041 T3600 T3568 punct .,expressed
R2042 T3602 T3603 det The,cloning
R2043 T3603 T3604 nsubj cloning,are
R2044 T3605 T3603 cc and,cloning
R2045 T3606 T3603 conj characterization,cloning
R2046 T3607 T3603 prep of,cloning
R2047 T3608 T3609 det the,family
R2048 T3609 T3607 pobj family,of
R2049 T3610 T3609 compound mouse,family
R2050 T3611 T3609 compound Acdp,family
R2051 T3612 T3609 compound gene,family
R2052 T3613 T3614 det a,step
R2053 T3614 T3604 attr step,are
R2054 T3615 T3616 advmod very,important
R2055 T3616 T3614 amod important,step
R2056 T3617 T3614 prep towards,step
R2057 T3618 T3619 det the,elucidation
R2058 T3619 T3617 pobj elucidation,towards
R2059 T3620 T3619 prep of,elucidation
R2060 T3621 T3622 det the,functions
R2061 T3622 T3620 pobj functions,of
R2062 T3623 T3622 prep of,functions
R2063 T3624 T3625 det this,family
R2064 T3625 T3623 pobj family,of
R2065 T3626 T3625 amod multigene,family
R2066 T3627 T3604 punct .,are
R2067 T3629 T3630 compound Sequence,analyses
R2068 T3630 T3632 nsubj analyses,revealed
R2069 T3631 T3630 compound homology,analyses
R2070 T3633 T3634 mark that,shared
R2071 T3634 T3632 ccomp shared,revealed
R2072 T3635 T3636 compound Acdp,proteins
R2073 T3636 T3634 nsubj proteins,shared
R2074 T3637 T3638 advmod very,strong
R2075 T3638 T3639 amod strong,homologies
R2076 T3639 T3634 dobj homologies,shared
R2077 T3640 T3639 compound AA,homologies
R2078 T3641 T3639 prep to,homologies
R2079 T3642 T3643 det the,protein
R2080 T3643 T3641 pobj protein,to
R2081 T3644 T3643 compound bacteria,protein
R2082 T3645 T3643 compound CorC,protein
R2083 T3646 T3643 cc and,protein
R2084 T3647 T3648 compound yeast,protein
R2085 T3648 T3643 conj protein,protein
R2086 T3649 T3648 compound Amip3,protein
R2087 T3650 T3632 punct .,revealed
R2088 T3652 T3653 nsubj CorA,belong
R2089 T3654 T3652 punct ", ",CorA
R2090 T3655 T3652 conj B,CorA
R2091 T3656 T3655 punct ", ",B
R2092 T3657 T3655 conj C,B
R2093 T3658 T3657 cc and,C
R2094 T3659 T3657 conj D,C
R2095 T3660 T3653 prep to,belong
R2096 T3661 T3662 det a,family
R2097 T3662 T3660 pobj family,to
R2098 T3663 T3662 compound protein,family
R2099 T3664 T3662 acl involved,family
R2100 T3665 T3664 prep in,involved
R2101 T3666 T3667 preconj both,influx
R2102 T3667 T3665 pobj influx,in
R2103 T3668 T3667 cc and,influx
R2104 T3669 T3667 conj efflux,influx
R2105 T3670 T3667 prep of,influx
R2106 T3671 T3670 pobj magnesium,of
R2107 T3672 T3671 cc and,magnesium
R2108 T3673 T3671 conj cobalt,magnesium
R2109 T3674 T3653 punct .,belong
R2110 T3676 T3677 nsubjpass It,shown
R2111 T3678 T3677 aux has,shown
R2112 T3679 T3677 auxpass been,shown
R2113 T3680 T3681 mark that,confer
R2114 T3681 T3677 ccomp confer,shown
R2115 T3682 T3683 compound CorA,mutants
R2116 T3683 T3681 nsubj mutants,confer
R2117 T3684 T3681 dobj resistance,confer
R2118 T3685 T3684 prep to,resistance
R2119 T3686 T3687 compound cobalt,toxicity
R2120 T3687 T3685 pobj toxicity,to
R2121 T3688 T3689 punct [,9
R2122 T3689 T3677 parataxis 9,shown
R2123 T3690 T3689 punct ],9
R2124 T3691 T3677 punct .,shown
R2125 T3693 T3694 nsubj Amip3,appears
R2126 T3695 T3696 aux to,be
R2127 T3696 T3694 xcomp be,appears
R2128 T3697 T3698 det a,homologous
R2129 T3698 T3696 attr homologous,be
R2130 T3699 T3698 prep to,homologous
R2131 T3700 T3701 compound CorC,protein
R2132 T3701 T3699 pobj protein,to
R2133 T3702 T3703 dep which,involved
R2134 T3703 T3701 relcl involved,protein
R2135 T3704 T3703 auxpass is,involved
R2136 T3705 T3703 prep in,involved
R2137 T3706 T3705 pobj efflux,in
R2138 T3707 T3706 prep of,efflux
R2139 T3708 T3707 pobj magnesium,of
R2140 T3709 T3708 cc and,magnesium
R2141 T3710 T3708 conj cobalt,magnesium
R2142 T3711 T3703 prep in,involved
R2143 T3712 T3711 pobj bacteria,in
R2144 T3713 T3694 punct .,appears
R2145 T3715 T3716 compound Amip3,mutants
R2146 T3716 T3717 nsubj mutants,confer
R2147 T3718 T3717 dobj resistant,confer
R2148 T3719 T3718 prep to,resistant
R2149 T3720 T3721 compound copper,toxicity
R2150 T3721 T3719 pobj toxicity,to
R2151 T3722 T3717 punct .,confer
R2152 T3724 T3725 nsubj Acdp,possess
R2153 T3726 T3725 dep proteins,possess
R2154 T3727 T3725 advmod also,possess
R2155 T3728 T3729 det the,domains
R2156 T3729 T3725 dobj domains,possess
R2157 T3730 T3731 dep that,found
R2158 T3731 T3729 relcl found,domains
R2159 T3732 T3731 auxpass are,found
R2160 T3733 T3731 prep in,found
R2161 T3734 T3735 nmod bacteria,CorC
R2162 T3735 T3736 nmod CorC,proteins
R2163 T3736 T3733 pobj proteins,in
R2164 T3737 T3735 cc and,CorC
R2165 T3738 T3739 compound yeast,Amip3
R2166 T3739 T3735 conj Amip3,CorC
R2167 T3740 T3729 punct ", ",domains
R2168 T3741 T3742 amod such,as
R2169 T3742 T3729 prep as,domains
R2170 T3743 T3744 det the,domains
R2171 T3744 T3742 pobj domains,as
R2172 T3745 T3744 compound CBS,domains
R2173 T3746 T3744 punct ", ",domains
R2174 T3747 T3748 compound DUF21,domain
R2175 T3748 T3744 conj domain,domains
R2176 T3749 T3748 cc and,domain
R2177 T3750 T3751 compound transmembrane,domains
R2178 T3751 T3748 conj domains,domain
R2179 T3752 T3725 punct .,possess
R2180 T3754 T3755 prep In,found
R2181 T3756 T3754 pobj addition,In
R2182 T3757 T3755 punct ", ",found
R2183 T3758 T3759 det a,domain
R2184 T3759 T3755 nsubjpass domain,found
R2185 T3760 T3761 npadvmod cNMP,binding
R2186 T3761 T3759 amod binding,domain
R2187 T3762 T3761 punct -,binding
R2188 T3763 T3755 auxpass was,found
R2189 T3764 T3755 prep in,found
R2190 T3765 T3766 det all,proteins
R2191 T3766 T3764 pobj proteins,in
R2192 T3767 T3766 compound Acdp,proteins
R2193 T3768 T3755 punct ", ",found
R2194 T3769 T3770 dep which,is
R2195 T3770 T3755 ccomp is,found
R2196 T3771 T3770 advmod usually,is
R2197 T3772 T3770 acomp present,is
R2198 T3773 T3770 prep in,is
R2199 T3774 T3775 compound ion,channels
R2200 T3775 T3773 pobj channels,in
R2201 T3776 T3775 cc and,channels
R2202 T3777 T3778 nmod cNMP,kinases
R2203 T3778 T3775 conj kinases,channels
R2204 T3779 T3777 punct -,cNMP
R2205 T3780 T3777 amod dependent,cNMP
R2206 T3781 T3782 punct [,10
R2207 T3782 T3755 parataxis 10,found
R2208 T3783 T3784 punct -,13
R2209 T3784 T3782 prep 13,10
R2210 T3785 T3782 punct ],10
R2211 T3786 T3755 punct .,found
R2212 T3788 T3789 advcl Using,shown
R2213 T3790 T3788 dobj antibody,Using
R2214 T3791 T3790 acl produced,antibody
R2215 T3792 T3791 agent by,produced
R2216 T3793 T3794 nmod Acdp1,peptide
R2217 T3794 T3792 pobj peptide,by
R2218 T3795 T3796 npadvmod C,terminal
R2219 T3796 T3794 amod terminal,peptide
R2220 T3797 T3796 punct -,terminal
R2221 T3798 T3789 punct ", ",shown
R2222 T3799 T3789 nsubj we,shown
R2223 T3800 T3789 aux have,shown
R2224 T3801 T3802 mark that,localized
R2225 T3802 T3789 ccomp localized,shown
R2226 T3803 T3802 nsubjpass Acdp1,localized
R2227 T3804 T3802 auxpass is,localized
R2228 T3805 T3802 advmod predominantly,localized
R2229 T3806 T3802 prep on,localized
R2230 T3807 T3808 det the,membrane
R2231 T3808 T3806 pobj membrane,on
R2232 T3809 T3808 compound plasma,membrane
R2233 T3810 T3802 prep in,localized
R2234 T3811 T3812 compound hippocampus,neurons
R2235 T3812 T3810 pobj neurons,in
R2236 T3813 T3789 punct .,shown
R2237 T3815 T3816 prep In,found
R2238 T3817 T3818 poss our,study
R2239 T3818 T3815 pobj study,In
R2240 T3819 T3818 amod previous,study
R2241 T3820 T3816 punct ", ",found
R2242 T3821 T3816 nsubj we,found
R2243 T3822 T3823 amod human,proteins
R2244 T3823 T3825 nsubjpass proteins,localized
R2245 T3824 T3823 compound ACDP,proteins
R2246 T3825 T3816 advcl localized,found
R2247 T3826 T3825 auxpass are,localized
R2248 T3827 T3825 advmod predominantly,localized
R2249 T3828 T3825 prep in,localized
R2250 T3829 T3830 det the,nucleus
R2251 T3830 T3828 pobj nucleus,in
R2252 T3831 T3825 prep in,localized
R2253 T3832 T3833 compound HeLa,cells
R2254 T3833 T3831 pobj cells,in
R2255 T3834 T3835 punct [,1
R2256 T3835 T3816 parataxis 1,found
R2257 T3836 T3835 punct ],1
R2258 T3837 T3816 punct .,found
R2259 T3839 T3840 det The,discrepancy
R2260 T3840 T3841 nsubjpass discrepancy,caused
R2261 T3842 T3840 prep for,discrepancy
R2262 T3843 T3844 compound Acdp,localization
R2263 T3844 T3842 pobj localization,for
R2264 T3845 T3844 prep in,localization
R2265 T3846 T3847 amod neuronal,cells
R2266 T3847 T3845 pobj cells,in
R2267 T3848 T3841 aux could,caused
R2268 T3849 T3841 auxpass be,caused
R2269 T3850 T3841 agent by,caused
R2270 T3851 T3850 pobj non-specificity,by
R2271 T3852 T3851 prep for,non-specificity
R2272 T3853 T3854 amod previous,antibody
R2273 T3854 T3852 pobj antibody,for
R2274 T3855 T3856 dep which,produced
R2275 T3856 T3854 relcl produced,antibody
R2276 T3857 T3856 auxpass was,produced
R2277 T3858 T3856 prep by,produced
R2278 T3859 T3860 det the,domain
R2279 T3860 T3858 pobj domain,by
R2280 T3861 T3860 amod recombinant,domain
R2281 T3862 T3860 compound ACD,domain
R2282 T3863 T3851 punct ", ",non-specificity
R2283 T3864 T3851 cc or,non-specificity
R2284 T3865 T3866 amod different,cells
R2285 T3866 T3851 conj cells,non-specificity
R2286 T3867 T3866 acl used,cells
R2287 T3868 T3841 punct .,caused
R2288 T3870 T3871 prep In,recognizes
R2289 T3872 T3873 amod current,study
R2290 T3873 T3870 pobj study,In
R2291 T3874 T3871 punct ", ",recognizes
R2292 T3875 T3876 det the,antibody
R2293 T3876 T3871 nsubj antibody,recognizes
R2294 T3877 T3876 compound Acdp1,antibody
R2295 T3878 T3879 compound C,terminus
R2296 T3879 T3876 compound terminus,antibody
R2297 T3880 T3879 punct -,terminus
R2298 T3881 T3871 advmod only,recognizes
R2299 T3882 T3871 dobj Acdp1,recognizes
R2300 T3883 T3871 prep in,recognizes
R2301 T3884 T3885 compound brain,tissue
R2302 T3885 T3886 compound tissue,extracts
R2303 T3886 T3883 pobj extracts,in
R2304 T3887 T3888 advmod as,as
R2305 T3888 T3883 cc as,in
R2306 T3889 T3888 advmod well,as
R2307 T3890 T3883 conj in,in
R2308 T3891 T3892 nmod HEK293,lysates
R2309 T3892 T3890 pobj lysates,in
R2310 T3893 T3891 punct ", ",HEK293
R2311 T3894 T3891 conj 3T3,HEK293
R2312 T3895 T3894 cc and,3T3
R2313 T3896 T3894 conj PC12,3T3
R2314 T3897 T3892 compound cell,lysates
R2315 T3898 T3871 punct ", ",recognizes
R2316 T3899 T3871 advcl suggesting,recognizes
R2317 T3900 T3901 det the,specificity
R2318 T3901 T3899 dobj specificity,suggesting
R2319 T3902 T3901 prep of,specificity
R2320 T3903 T3904 det the,antibody
R2321 T3904 T3902 pobj antibody,of
R2322 T3905 T3871 punct .,recognizes
R2323 T3907 T3908 poss Our,observations
R2324 T3908 T3909 nsubj observations,suggested
R2325 T3910 T3911 mark that,involved
R2326 T3911 T3909 ccomp involved,suggested
R2327 T3912 T3911 nsubjpass Acdp,involved
R2328 T3913 T3911 aux might,involved
R2329 T3914 T3911 auxpass be,involved
R2330 T3915 T3911 prep in,involved
R2331 T3916 T3917 compound ion,transport
R2332 T3917 T3915 pobj transport,in
R2333 T3918 T3911 prep in,involved
R2334 T3919 T3920 amod mammalian,cells
R2335 T3920 T3918 pobj cells,in
R2336 T3921 T3909 punct .,suggested
R2337 T3923 T3924 advmod However,needed
R2338 T3925 T3924 punct ", ",needed
R2339 T3926 T3927 advmod more,detailed
R2340 T3927 T3928 amod detailed,studies
R2341 T3928 T3924 nsubjpass studies,needed
R2342 T3929 T3928 amod functional,studies
R2343 T3930 T3924 auxpass are,needed
R2344 T3931 T3932 aux to,demonstrate
R2345 T3932 T3924 advcl demonstrate,needed
R2346 T3933 T3934 det the,functions
R2347 T3934 T3932 dobj functions,demonstrate
R2348 T3935 T3934 amod real,functions
R2349 T3936 T3934 prep of,functions
R2350 T3937 T3938 det these,proteins
R2351 T3938 T3936 pobj proteins,of
R2352 T3939 T3924 punct .,needed