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PMC:1860061 / 1269-5849 JSONTXT 5 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T2422 13-27 NN denotes Susceptibility
T2424 28-30 IN denotes to
T2425 31-35 RBS denotes most
T2427 36-43 JJ denotes complex
T2426 44-52 NNS denotes diseases
T2428 53-55 VBZ denotes is
T2423 56-66 VBN denotes controlled
T2429 67-69 IN denotes by
T2430 70-74 JJ denotes many
T2431 75-80 NNS denotes genes
T2432 80-82 , denotes ,
T2433 82-86 RB denotes each
T2434 87-93 VBG denotes having
T2435 94-95 DT denotes a
T2437 96-101 JJ denotes small
T2436 102-108 NN denotes effect
T2438 109-111 IN denotes on
T2439 112-115 DT denotes the
T2440 116-123 NN denotes disease
T2441 123-124 . denotes .
T2442 124-218 sentence denotes One example is rheumatoid arthritis (RA), a common complex multifactorial autoimmune disease.
T2443 125-128 CD denotes One
T2444 129-136 NN denotes example
T2445 137-139 VBZ denotes is
T2446 140-150 JJ denotes rheumatoid
T2447 151-160 NN denotes arthritis
T2448 161-162 -LRB- denotes (
T2449 162-164 NN denotes RA
T2450 164-165 -RRB- denotes )
T2451 165-167 , denotes ,
T2452 167-168 DT denotes a
T2454 169-175 JJ denotes common
T2455 176-183 NN denotes complex
T2456 184-198 JJ denotes multifactorial
T2457 199-209 JJ denotes autoimmune
T2453 210-217 NN denotes disease
T2458 217-218 . denotes .
T2459 218-371 sentence denotes Several studies have been carried out to detect the genetic basis of RA, and more than 30 genomic regions have shown evidence of linkage to the disease.
T2460 219-226 JJ denotes Several
T2461 227-234 NNS denotes studies
T2463 235-239 VBP denotes have
T2464 240-244 VBN denotes been
T2462 245-252 VBN denotes carried
T2465 253-256 RP denotes out
T2466 257-259 TO denotes to
T2467 260-266 VB denotes detect
T2468 267-270 DT denotes the
T2470 271-278 JJ denotes genetic
T2469 279-284 NN denotes basis
T2471 285-287 IN denotes of
T2472 288-290 NN denotes RA
T2473 290-292 , denotes ,
T2474 292-295 CC denotes and
T2475 296-300 JJR denotes more
T2477 301-305 IN denotes than
T2476 306-308 CD denotes 30
T2479 309-316 JJ denotes genomic
T2478 317-324 NNS denotes regions
T2481 325-329 VBP denotes have
T2480 330-335 VBN denotes shown
T2482 336-344 NN denotes evidence
T2483 345-347 IN denotes of
T2484 348-355 NN denotes linkage
T2485 356-358 IN denotes to
T2486 359-362 DT denotes the
T2487 363-370 NN denotes disease
T2488 370-371 . denotes .
T2489 371-513 sentence denotes Most of these genomic regions did not reach a genome-wide significant threshold value of linkage, with P values between 0.05 and 0.001 [1-5].
T2490 372-376 JJS denotes Most
T2492 377-379 IN denotes of
T2493 380-385 DT denotes these
T2495 386-393 JJ denotes genomic
T2494 394-401 NNS denotes regions
T2496 402-405 VBD denotes did
T2497 406-409 RB denotes not
T2491 410-415 VB denotes reach
T2498 416-417 DT denotes a
T2500 418-424 NN denotes genome
T2502 424-425 HYPH denotes -
T2501 425-429 JJ denotes wide
T2503 430-441 JJ denotes significant
T2504 442-451 NN denotes threshold
T2499 452-457 NN denotes value
T2505 458-460 IN denotes of
T2506 461-468 NN denotes linkage
T2507 468-470 , denotes ,
T2508 470-474 IN denotes with
T2509 475-476 NN denotes P
T2510 477-483 NNS denotes values
T2511 484-491 IN denotes between
T2512 492-496 CD denotes 0.05
T2513 497-500 CC denotes and
T2514 501-506 CD denotes 0.001
T2515 507-508 -LRB- denotes [
T2516 508-509 CD denotes 1
T2517 509-510 SYM denotes -
T2518 510-511 CD denotes 5
T2519 511-512 -RRB- denotes ]
T2520 512-513 . denotes .
T2521 513-562 sentence denotes Thus, these loci only have a small effect on RA.
T2522 514-518 RB denotes Thus
T2524 518-520 , denotes ,
T2525 520-525 DT denotes these
T2526 526-530 NNS denotes loci
T2527 531-535 RB denotes only
T2523 536-540 VBP denotes have
T2528 541-542 DT denotes a
T2530 543-548 JJ denotes small
T2529 549-555 NN denotes effect
T2531 556-558 IN denotes on
T2532 559-561 NN denotes RA
T2533 561-562 . denotes .
T2534 562-714 sentence denotes Small genetic contributions could also be seen from the susceptibility genes of RA identified so far, including HLA-DR4, PADI4, PTPN22 and FCRL3 [6-9].
T2535 563-568 JJ denotes Small
T2537 569-576 JJ denotes genetic
T2536 577-590 NNS denotes contributions
T2539 591-596 MD denotes could
T2540 597-601 RB denotes also
T2541 602-604 VB denotes be
T2538 605-609 VBN denotes seen
T2542 610-614 IN denotes from
T2543 615-618 DT denotes the
T2545 619-633 NN denotes susceptibility
T2544 634-639 NNS denotes genes
T2546 640-642 IN denotes of
T2547 643-645 NN denotes RA
T2548 646-656 VBN denotes identified
T2549 657-659 RB denotes so
T2550 660-663 RB denotes far
T2551 663-665 , denotes ,
T2552 665-674 VBG denotes including
T2553 675-678 NN denotes HLA
T2555 678-679 HYPH denotes -
T2554 679-682 NN denotes DR4
T2556 682-684 , denotes ,
T2557 684-689 NN denotes PADI4
T2558 689-691 , denotes ,
T2559 691-697 NN denotes PTPN22
T2560 698-701 CC denotes and
T2561 702-707 NN denotes FCRL3
T2562 708-709 -LRB- denotes [
T2563 709-710 CD denotes 6
T2564 710-711 SYM denotes -
T2565 711-712 CD denotes 9
T2566 712-713 -RRB- denotes ]
T2567 713-714 . denotes .
T2568 714-848 sentence denotes Except for HLA-DR4, which is strongly associated with RA, all the other susceptibility genes have only a small effect on the disease.
T2569 715-721 IN denotes Except
T2571 722-725 IN denotes for
T2572 726-729 NN denotes HLA
T2574 729-730 HYPH denotes -
T2573 730-733 NN denotes DR4
T2575 733-735 , denotes ,
T2576 735-740 WDT denotes which
T2578 741-743 VBZ denotes is
T2579 744-752 RB denotes strongly
T2577 753-763 VBN denotes associated
T2580 764-768 IN denotes with
T2581 769-771 NN denotes RA
T2582 771-773 , denotes ,
T2583 773-776 PDT denotes all
T2585 777-780 DT denotes the
T2586 781-786 JJ denotes other
T2587 787-801 NN denotes susceptibility
T2584 802-807 NNS denotes genes
T2570 808-812 VBP denotes have
T2588 813-817 RB denotes only
T2590 818-819 DT denotes a
T2591 820-825 JJ denotes small
T2589 826-832 NN denotes effect
T2592 833-835 IN denotes on
T2593 836-839 DT denotes the
T2594 840-847 NN denotes disease
T2595 847-848 . denotes .
T2596 848-927 sentence denotes In the mouse model of RA, small genetic contributions are also often observed.
T2597 849-851 IN denotes In
T2599 852-855 DT denotes the
T2601 856-861 NN denotes mouse
T2600 862-867 NN denotes model
T2602 868-870 IN denotes of
T2603 871-873 NN denotes RA
T2604 873-875 , denotes ,
T2605 875-880 JJ denotes small
T2607 881-888 JJ denotes genetic
T2606 889-902 NNS denotes contributions
T2608 903-906 VBP denotes are
T2609 907-911 RB denotes also
T2610 912-917 RB denotes often
T2598 918-926 VBN denotes observed
T2611 926-927 . denotes .
T2612 927-1118 sentence denotes For example, in a previous study, we carried out a genome screen to identify the quantitative trait loci (QTL) in collagen-induced arthritis (CIA), which is a widely used animal model of RA.
T2613 928-931 IN denotes For
T2615 932-939 NN denotes example
T2616 939-941 , denotes ,
T2617 941-943 IN denotes in
T2618 944-945 DT denotes a
T2620 946-954 JJ denotes previous
T2619 955-960 NN denotes study
T2621 960-962 , denotes ,
T2622 962-964 PRP denotes we
T2614 965-972 VBD denotes carried
T2623 973-976 RP denotes out
T2624 977-978 DT denotes a
T2626 979-985 NN denotes genome
T2625 986-992 NN denotes screen
T2627 993-995 TO denotes to
T2628 996-1004 VB denotes identify
T2629 1005-1008 DT denotes the
T2631 1009-1021 JJ denotes quantitative
T2632 1022-1027 NN denotes trait
T2630 1028-1032 NNS denotes loci
T2633 1033-1034 -LRB- denotes (
T2634 1034-1037 NN denotes QTL
T2635 1037-1038 -RRB- denotes )
T2636 1039-1041 IN denotes in
T2637 1042-1050 NN denotes collagen
T2639 1050-1051 HYPH denotes -
T2638 1051-1058 VBN denotes induced
T2640 1059-1068 NN denotes arthritis
T2641 1069-1070 -LRB- denotes (
T2642 1070-1073 NN denotes CIA
T2643 1073-1074 -RRB- denotes )
T2644 1074-1076 , denotes ,
T2645 1076-1081 WDT denotes which
T2646 1082-1084 VBZ denotes is
T2647 1085-1086 DT denotes a
T2649 1087-1093 RB denotes widely
T2650 1094-1098 VBN denotes used
T2651 1099-1105 NN denotes animal
T2648 1106-1111 NN denotes model
T2652 1112-1114 IN denotes of
T2653 1115-1117 NN denotes RA
T2654 1117-1118 . denotes .
T2655 1118-1296 sentence denotes Only one QTL, Cia2, was identified for the phenotype of CIA severity, but this QTL contributes to only 16% of the phenotype variations for CIA susceptibility in F2 progeny [10].
T2656 1119-1123 RB denotes Only
T2658 1124-1127 CD denotes one
T2657 1128-1131 NN denotes QTL
T2660 1131-1133 , denotes ,
T2661 1133-1137 NN denotes Cia2
T2662 1137-1139 , denotes ,
T2663 1139-1142 VBD denotes was
T2659 1143-1153 VBN denotes identified
T2664 1154-1157 IN denotes for
T2665 1158-1161 DT denotes the
T2666 1162-1171 NN denotes phenotype
T2667 1172-1174 IN denotes of
T2668 1175-1178 NN denotes CIA
T2669 1179-1187 NN denotes severity
T2670 1187-1189 , denotes ,
T2671 1189-1192 CC denotes but
T2672 1193-1197 DT denotes this
T2673 1198-1201 NN denotes QTL
T2674 1202-1213 VBZ denotes contributes
T2675 1214-1216 IN denotes to
T2676 1217-1221 RB denotes only
T2677 1222-1224 CD denotes 16
T2678 1224-1225 NN denotes %
T2679 1226-1228 IN denotes of
T2680 1229-1232 DT denotes the
T2682 1233-1242 NN denotes phenotype
T2681 1243-1253 NNS denotes variations
T2683 1254-1257 IN denotes for
T2684 1258-1261 NN denotes CIA
T2685 1262-1276 NN denotes susceptibility
T2686 1277-1279 IN denotes in
T2687 1280-1282 NN denotes F2
T2688 1283-1290 NN denotes progeny
T2689 1291-1292 -LRB- denotes [
T2690 1292-1294 CD denotes 10
T2691 1294-1295 -RRB- denotes ]
T2692 1295-1296 . denotes .
T2693 1296-1469 sentence denotes This suggests that there must be other susceptibility genes whose contributions were not big enough to reach the stringent significance threshold value of linkage analysis.
T2694 1297-1301 DT denotes This
T2695 1302-1310 VBZ denotes suggests
T2696 1311-1315 IN denotes that
T2698 1316-1321 EX denotes there
T2699 1322-1326 MD denotes must
T2697 1327-1329 VB denotes be
T2700 1330-1335 JJ denotes other
T2702 1336-1350 NN denotes susceptibility
T2701 1351-1356 NNS denotes genes
T2703 1357-1362 WP$ denotes whose
T2704 1363-1376 NNS denotes contributions
T2705 1377-1381 VBD denotes were
T2706 1382-1385 RB denotes not
T2707 1386-1389 JJ denotes big
T2708 1390-1396 RB denotes enough
T2709 1397-1399 TO denotes to
T2710 1400-1405 VB denotes reach
T2711 1406-1409 DT denotes the
T2713 1410-1419 JJ denotes stringent
T2714 1420-1432 NN denotes significance
T2715 1433-1442 NN denotes threshold
T2712 1443-1448 NN denotes value
T2716 1449-1451 IN denotes of
T2717 1452-1459 NN denotes linkage
T2718 1460-1468 NN denotes analysis
T2719 1468-1469 . denotes .
T2720 1469-1571 sentence denotes One aim of using animal models for complex diseases is to detect the genetic basis of these diseases.
T2721 1470-1473 CD denotes One
T2722 1474-1477 NN denotes aim
T2724 1478-1480 IN denotes of
T2725 1481-1486 VBG denotes using
T2726 1487-1493 NN denotes animal
T2727 1494-1500 NNS denotes models
T2728 1501-1504 IN denotes for
T2729 1505-1512 JJ denotes complex
T2730 1513-1521 NNS denotes diseases
T2723 1522-1524 VBZ denotes is
T2731 1525-1527 TO denotes to
T2732 1528-1534 VB denotes detect
T2733 1535-1538 DT denotes the
T2735 1539-1546 JJ denotes genetic
T2734 1547-1552 NN denotes basis
T2736 1553-1555 IN denotes of
T2737 1556-1561 DT denotes these
T2738 1562-1570 NNS denotes diseases
T2739 1570-1571 . denotes .
T2740 1571-1795 sentence denotes With controllable environmental factors as well as the known genetic background, animal models are powerful tools to search for susceptibility genes for complex diseases, and have been intensively employed for that purpose.
T2741 1572-1576 IN denotes With
T2743 1577-1589 JJ denotes controllable
T2745 1590-1603 JJ denotes environmental
T2744 1604-1611 NNS denotes factors
T2746 1612-1614 RB denotes as
T2748 1615-1619 RB denotes well
T2747 1620-1622 IN denotes as
T2749 1623-1626 DT denotes the
T2751 1627-1632 JJ denotes known
T2752 1633-1640 JJ denotes genetic
T2750 1641-1651 NN denotes background
T2753 1651-1653 , denotes ,
T2754 1653-1659 NN denotes animal
T2755 1660-1666 NNS denotes models
T2742 1667-1670 VBP denotes are
T2756 1671-1679 JJ denotes powerful
T2757 1680-1685 NNS denotes tools
T2758 1686-1688 TO denotes to
T2759 1689-1695 VB denotes search
T2760 1696-1699 IN denotes for
T2761 1700-1714 NN denotes susceptibility
T2762 1715-1720 NNS denotes genes
T2763 1721-1724 IN denotes for
T2764 1725-1732 JJ denotes complex
T2765 1733-1741 NNS denotes diseases
T2766 1741-1743 , denotes ,
T2767 1743-1746 CC denotes and
T2768 1747-1751 VBP denotes have
T2770 1752-1756 VBN denotes been
T2771 1757-1768 RB denotes intensively
T2769 1769-1777 VBN denotes employed
T2772 1778-1781 IN denotes for
T2773 1782-1786 DT denotes that
T2774 1787-1794 NN denotes purpose
T2775 1794-1795 . denotes .
T2776 1795-1928 sentence denotes More than 27,000 QTL have been identified in the mouse genome since the first QTL was identified at the beginning of the 1990s [11].
T2777 1796-1800 JJR denotes More
T2779 1801-1805 IN denotes than
T2778 1806-1812 CD denotes 27,000
T2780 1813-1816 NN denotes QTL
T2782 1817-1821 VBP denotes have
T2783 1822-1826 VBN denotes been
T2781 1827-1837 VBN denotes identified
T2784 1838-1840 IN denotes in
T2785 1841-1844 DT denotes the
T2787 1845-1850 NN denotes mouse
T2786 1851-1857 NN denotes genome
T2788 1858-1863 IN denotes since
T2790 1864-1867 DT denotes the
T2792 1868-1873 JJ denotes first
T2791 1874-1877 NN denotes QTL
T2793 1878-1881 VBD denotes was
T2789 1882-1892 VBN denotes identified
T2794 1893-1895 IN denotes at
T2795 1896-1899 DT denotes the
T2796 1900-1909 NN denotes beginning
T2797 1910-1912 IN denotes of
T2798 1913-1916 DT denotes the
T2799 1917-1922 NNS denotes 1990s
T2800 1923-1924 -LRB- denotes [
T2801 1924-1926 CD denotes 11
T2802 1926-1927 -RRB- denotes ]
T2803 1927-1928 . denotes .
T2804 1928-2035 sentence denotes By 2005, approximately 20 quantitative trait genes (QTGs) in the mouse genome had been identified [12,13].
T2805 1929-1931 IN denotes By
T2807 1932-1936 CD denotes 2005
T2808 1936-1938 , denotes ,
T2809 1938-1951 RB denotes approximately
T2810 1952-1954 CD denotes 20
T2812 1955-1967 JJ denotes quantitative
T2813 1968-1973 NN denotes trait
T2811 1974-1979 NNS denotes genes
T2814 1980-1981 -LRB- denotes (
T2815 1981-1985 NNS denotes QTGs
T2816 1985-1986 -RRB- denotes )
T2817 1987-1989 IN denotes in
T2818 1990-1993 DT denotes the
T2820 1994-1999 NN denotes mouse
T2819 2000-2006 NN denotes genome
T2821 2007-2010 VBD denotes had
T2822 2011-2015 VBN denotes been
T2806 2016-2026 VBN denotes identified
T2823 2027-2028 -LRB- denotes [
T2825 2028-2030 CD denotes 12
T2826 2030-2031 , denotes ,
T2824 2031-2033 CD denotes 13
T2827 2033-2034 -RRB- denotes ]
T2828 2034-2035 . denotes .
T2829 2035-2216 sentence denotes Interestingly, most QTGs identified in animal models have the causal polymorphisms in the protein-coding region [14], which provoke protein structure changes or protein deficiency.
T2830 2036-2049 RB denotes Interestingly
T2832 2049-2051 , denotes ,
T2833 2051-2055 JJS denotes most
T2834 2056-2060 NNS denotes QTGs
T2835 2061-2071 VBN denotes identified
T2836 2072-2074 IN denotes in
T2837 2075-2081 NN denotes animal
T2838 2082-2088 NNS denotes models
T2831 2089-2093 VBP denotes have
T2839 2094-2097 DT denotes the
T2841 2098-2104 JJ denotes causal
T2840 2105-2118 NNS denotes polymorphisms
T2842 2119-2121 IN denotes in
T2843 2122-2125 DT denotes the
T2845 2126-2133 NN denotes protein
T2847 2133-2134 HYPH denotes -
T2846 2134-2140 VBG denotes coding
T2844 2141-2147 NN denotes region
T2848 2148-2149 -LRB- denotes [
T2849 2149-2151 CD denotes 14
T2850 2151-2152 -RRB- denotes ]
T2851 2152-2154 , denotes ,
T2852 2154-2159 WDT denotes which
T2853 2160-2167 VBP denotes provoke
T2854 2168-2175 NN denotes protein
T2856 2176-2185 NN denotes structure
T2855 2186-2193 NNS denotes changes
T2857 2194-2196 CC denotes or
T2858 2197-2204 NN denotes protein
T2859 2205-2215 NN denotes deficiency
T2860 2215-2216 . denotes .
T2861 2216-2491 sentence denotes This suggests, on the one hand, that small-effect QTL are difficult to identify with traditional strategies and, on the other hand, that the polymorphisms regulating gene expression might only slightly affect the quantitative traits, and thus are more difficult to identify.
T2862 2217-2221 DT denotes This
T2863 2222-2230 VBZ denotes suggests
T2864 2230-2232 , denotes ,
T2865 2232-2234 IN denotes on
T2867 2235-2238 DT denotes the
T2869 2239-2242 CD denotes one
T2868 2243-2247 NN denotes hand
T2870 2247-2249 , denotes ,
T2871 2249-2253 IN denotes that
T2872 2254-2259 JJ denotes small
T2874 2259-2260 HYPH denotes -
T2873 2260-2266 NN denotes effect
T2875 2267-2270 NN denotes QTL
T2866 2271-2274 VBP denotes are
T2876 2275-2284 JJ denotes difficult
T2877 2285-2287 TO denotes to
T2878 2288-2296 VB denotes identify
T2879 2297-2301 IN denotes with
T2880 2302-2313 JJ denotes traditional
T2881 2314-2324 NNS denotes strategies
T2882 2325-2328 CC denotes and
T2883 2328-2330 , denotes ,
T2884 2330-2332 IN denotes on
T2886 2333-2336 DT denotes the
T2888 2337-2342 JJ denotes other
T2887 2343-2347 NN denotes hand
T2889 2347-2349 , denotes ,
T2890 2349-2353 IN denotes that
T2891 2354-2357 DT denotes the
T2892 2358-2371 NNS denotes polymorphisms
T2893 2372-2382 VBG denotes regulating
T2894 2383-2387 NN denotes gene
T2895 2388-2398 NN denotes expression
T2896 2399-2404 MD denotes might
T2897 2405-2409 RB denotes only
T2898 2410-2418 RB denotes slightly
T2885 2419-2425 VB denotes affect
T2899 2426-2429 DT denotes the
T2901 2430-2442 JJ denotes quantitative
T2900 2443-2449 NNS denotes traits
T2902 2449-2451 , denotes ,
T2903 2451-2454 CC denotes and
T2904 2455-2459 RB denotes thus
T2905 2460-2463 VBP denotes are
T2906 2464-2468 RBR denotes more
T2907 2469-2478 JJ denotes difficult
T2908 2479-2481 TO denotes to
T2909 2482-2490 VB denotes identify
T2910 2490-2491 . denotes .
T2911 2491-2591 sentence denotes Microarray-based global gene expression is a powerful technique for investigating complex diseases.
T2912 2492-2502 NN denotes Microarray
T2914 2502-2503 HYPH denotes -
T2913 2503-2508 VBN denotes based
T2916 2509-2515 JJ denotes global
T2917 2516-2520 NN denotes gene
T2915 2521-2531 NN denotes expression
T2918 2532-2534 VBZ denotes is
T2919 2535-2536 DT denotes a
T2921 2537-2545 JJ denotes powerful
T2920 2546-2555 NN denotes technique
T2922 2556-2559 IN denotes for
T2923 2560-2573 VBG denotes investigating
T2924 2574-2581 JJ denotes complex
T2925 2582-2590 NNS denotes diseases
T2926 2590-2591 . denotes .
T2927 2591-2692 sentence denotes During disease development, genes involved in the disease are likely to be differentially regulated.
T2928 2592-2598 IN denotes During
T2930 2599-2606 NN denotes disease
T2931 2607-2618 NN denotes development
T2932 2618-2620 , denotes ,
T2933 2620-2625 NNS denotes genes
T2934 2626-2634 VBN denotes involved
T2935 2635-2637 IN denotes in
T2936 2638-2641 DT denotes the
T2937 2642-2649 NN denotes disease
T2929 2650-2653 VBP denotes are
T2938 2654-2660 JJ denotes likely
T2939 2661-2663 TO denotes to
T2941 2664-2666 VB denotes be
T2942 2667-2681 RB denotes differentially
T2940 2682-2691 VBN denotes regulated
T2943 2691-2692 . denotes .
T2944 2692-2855 sentence denotes Therefore, signature genes of the diseases could be identified by detecting the expression patterns of the disease-related cells/tissues and their ideal controls.
T2945 2693-2702 RB denotes Therefore
T2947 2702-2704 , denotes ,
T2948 2704-2713 NN denotes signature
T2949 2714-2719 NNS denotes genes
T2950 2720-2722 IN denotes of
T2951 2723-2726 DT denotes the
T2952 2727-2735 NNS denotes diseases
T2953 2736-2741 MD denotes could
T2954 2742-2744 VB denotes be
T2946 2745-2755 VBN denotes identified
T2955 2756-2758 IN denotes by
T2956 2759-2768 VBG denotes detecting
T2957 2769-2772 DT denotes the
T2959 2773-2783 NN denotes expression
T2958 2784-2792 NNS denotes patterns
T2960 2793-2795 IN denotes of
T2961 2796-2799 DT denotes the
T2963 2800-2807 NN denotes disease
T2965 2807-2808 HYPH denotes -
T2964 2808-2815 VBN denotes related
T2966 2816-2821 NNS denotes cells
T2967 2821-2822 HYPH denotes /
T2962 2822-2829 NNS denotes tissues
T2968 2830-2833 CC denotes and
T2969 2834-2839 PRP$ denotes their
T2971 2840-2845 JJ denotes ideal
T2970 2846-2854 NNS denotes controls
T2972 2854-2855 . denotes .
T2973 2855-2959 sentence denotes In the past decade, many studies applied this technique to study both RA and its animal models [15-22].
T2974 2856-2858 IN denotes In
T2976 2859-2862 DT denotes the
T2978 2863-2867 JJ denotes past
T2977 2868-2874 NN denotes decade
T2979 2874-2876 , denotes ,
T2980 2876-2880 JJ denotes many
T2981 2881-2888 NNS denotes studies
T2975 2889-2896 VBD denotes applied
T2982 2897-2901 DT denotes this
T2983 2902-2911 NN denotes technique
T2984 2912-2914 TO denotes to
T2985 2915-2920 VB denotes study
T2986 2921-2925 CC denotes both
T2987 2926-2928 NN denotes RA
T2988 2929-2932 CC denotes and
T2989 2933-2936 PRP$ denotes its
T2991 2937-2943 NN denotes animal
T2990 2944-2950 NNS denotes models
T2992 2951-2952 -LRB- denotes [
T2993 2952-2954 CD denotes 15
T2994 2954-2955 SYM denotes -
T2995 2955-2957 CD denotes 22
T2996 2957-2958 -RRB- denotes ]
T2997 2958-2959 . denotes .
T2998 2959-3088 sentence denotes Indeed, genes involved in arthritis show distinct expression patterns in certain tissues and pathological stages of the disease.
T2999 2960-2966 RB denotes Indeed
T3001 2966-2968 , denotes ,
T3002 2968-2973 NNS denotes genes
T3003 2974-2982 VBN denotes involved
T3004 2983-2985 IN denotes in
T3005 2986-2995 NN denotes arthritis
T3000 2996-3000 VBP denotes show
T3006 3001-3009 JJ denotes distinct
T3008 3010-3020 NN denotes expression
T3007 3021-3029 NNS denotes patterns
T3009 3030-3032 IN denotes in
T3010 3033-3040 JJ denotes certain
T3011 3041-3048 NNS denotes tissues
T3012 3049-3052 CC denotes and
T3013 3053-3065 JJ denotes pathological
T3014 3066-3072 NNS denotes stages
T3015 3073-3075 IN denotes of
T3016 3076-3079 DT denotes the
T3017 3080-3087 NN denotes disease
T3018 3087-3088 . denotes .
T3019 3088-3205 sentence denotes Genes involved in immunoinflammatory responses were differentially expressed in the blood cells in RA patients [18].
T3020 3089-3094 NNS denotes Genes
T3022 3095-3103 VBN denotes involved
T3023 3104-3106 IN denotes in
T3024 3107-3125 JJ denotes immunoinflammatory
T3025 3126-3135 NNS denotes responses
T3026 3136-3140 VBD denotes were
T3027 3141-3155 RB denotes differentially
T3021 3156-3165 VBN denotes expressed
T3028 3166-3168 IN denotes in
T3029 3169-3172 DT denotes the
T3031 3173-3178 NN denotes blood
T3030 3179-3184 NNS denotes cells
T3032 3185-3187 IN denotes in
T3033 3188-3190 NN denotes RA
T3034 3191-3199 NNS denotes patients
T3035 3200-3201 -LRB- denotes [
T3036 3201-3203 CD denotes 18
T3037 3203-3204 -RRB- denotes ]
T3038 3204-3205 . denotes .
T3039 3205-3488 sentence denotes Chemokines and adhesion molecules were upregulated in the joint at the initiation phase of arthritis in animal models [21,22], while genes involved in cartilage destruction and bone erosion were differentially expressed at the late phase of arthritis in animal models of RA [15,16].
T3040 3206-3216 NNS denotes Chemokines
T3042 3217-3220 CC denotes and
T3043 3221-3229 NN denotes adhesion
T3044 3230-3239 NNS denotes molecules
T3045 3240-3244 VBD denotes were
T3041 3245-3256 VBN denotes upregulated
T3046 3257-3259 IN denotes in
T3047 3260-3263 DT denotes the
T3048 3264-3269 NN denotes joint
T3049 3270-3272 IN denotes at
T3050 3273-3276 DT denotes the
T3052 3277-3287 NN denotes initiation
T3051 3288-3293 NN denotes phase
T3053 3294-3296 IN denotes of
T3054 3297-3306 NN denotes arthritis
T3055 3307-3309 IN denotes in
T3056 3310-3316 NN denotes animal
T3057 3317-3323 NNS denotes models
T3058 3324-3325 -LRB- denotes [
T3060 3325-3327 CD denotes 21
T3061 3327-3328 , denotes ,
T3059 3328-3330 CD denotes 22
T3062 3330-3331 -RRB- denotes ]
T3063 3331-3333 , denotes ,
T3064 3333-3338 IN denotes while
T3066 3339-3344 NNS denotes genes
T3067 3345-3353 VBN denotes involved
T3068 3354-3356 IN denotes in
T3069 3357-3366 NN denotes cartilage
T3070 3367-3378 NN denotes destruction
T3071 3379-3382 CC denotes and
T3072 3383-3387 NN denotes bone
T3073 3388-3395 NN denotes erosion
T3074 3396-3400 VBD denotes were
T3075 3401-3415 RB denotes differentially
T3065 3416-3425 VBN denotes expressed
T3076 3426-3428 IN denotes at
T3077 3429-3432 DT denotes the
T3079 3433-3437 JJ denotes late
T3078 3438-3443 NN denotes phase
T3080 3444-3446 IN denotes of
T3081 3447-3456 NN denotes arthritis
T3082 3457-3459 IN denotes in
T3083 3460-3466 NN denotes animal
T3084 3467-3473 NNS denotes models
T3085 3474-3476 IN denotes of
T3086 3477-3479 NN denotes RA
T3087 3480-3481 -LRB- denotes [
T3089 3481-3483 CD denotes 15
T3090 3483-3484 , denotes ,
T3088 3484-3486 CD denotes 16
T3091 3486-3487 -RRB- denotes ]
T3092 3487-3488 . denotes .
T3093 3488-3759 sentence denotes Besides detecting genes involved in complex diseases, microarrays could also be used to detect the genetic polymorphisms regulating gene expression because differential expressions between two strains might be the result of a polymorphism located in regulatory elements.
T3094 3489-3496 IN denotes Besides
T3095 3497-3506 VBG denotes detecting
T3097 3507-3512 NNS denotes genes
T3098 3513-3521 VBN denotes involved
T3099 3522-3524 IN denotes in
T3100 3525-3532 JJ denotes complex
T3101 3533-3541 NNS denotes diseases
T3102 3541-3543 , denotes ,
T3103 3543-3554 NNS denotes microarrays
T3104 3555-3560 MD denotes could
T3105 3561-3565 RB denotes also
T3106 3566-3568 VB denotes be
T3096 3569-3573 VBN denotes used
T3107 3574-3576 TO denotes to
T3108 3577-3583 VB denotes detect
T3109 3584-3587 DT denotes the
T3111 3588-3595 JJ denotes genetic
T3110 3596-3609 NNS denotes polymorphisms
T3112 3610-3620 VBG denotes regulating
T3113 3621-3625 NN denotes gene
T3114 3626-3636 NN denotes expression
T3115 3637-3644 IN denotes because
T3117 3645-3657 JJ denotes differential
T3118 3658-3669 NNS denotes expressions
T3119 3670-3677 IN denotes between
T3120 3678-3681 CD denotes two
T3121 3682-3689 NNS denotes strains
T3122 3690-3695 MD denotes might
T3116 3696-3698 VB denotes be
T3123 3699-3702 DT denotes the
T3124 3703-3709 NN denotes result
T3125 3710-3712 IN denotes of
T3126 3713-3714 DT denotes a
T3127 3715-3727 NN denotes polymorphism
T3128 3728-3735 VBN denotes located
T3129 3736-3738 IN denotes in
T3130 3739-3749 JJ denotes regulatory
T3131 3750-3758 NNS denotes elements
T3132 3758-3759 . denotes .
T3133 3759-3964 sentence denotes To identify the small-effect QTL of CIA as well as the potential candidate genes inside them, we investigated CIA genetically susceptible and resistant strains at both the genome and transcriptome levels.
T3134 3760-3762 TO denotes To
T3135 3763-3771 VB denotes identify
T3137 3772-3775 DT denotes the
T3139 3776-3781 JJ denotes small
T3141 3781-3782 HYPH denotes -
T3140 3782-3788 NN denotes effect
T3138 3789-3792 NN denotes QTL
T3142 3793-3795 IN denotes of
T3143 3796-3799 NN denotes CIA
T3144 3800-3802 RB denotes as
T3146 3803-3807 RB denotes well
T3145 3808-3810 IN denotes as
T3147 3811-3814 DT denotes the
T3149 3815-3824 JJ denotes potential
T3150 3825-3834 NN denotes candidate
T3148 3835-3840 NNS denotes genes
T3151 3841-3847 IN denotes inside
T3152 3848-3852 PRP denotes them
T3153 3852-3854 , denotes ,
T3154 3854-3856 PRP denotes we
T3136 3857-3869 VBD denotes investigated
T3155 3870-3873 NN denotes CIA
T3157 3874-3885 RB denotes genetically
T3156 3886-3897 JJ denotes susceptible
T3159 3898-3901 CC denotes and
T3160 3902-3911 JJ denotes resistant
T3158 3912-3919 NNS denotes strains
T3161 3920-3922 IN denotes at
T3162 3923-3927 CC denotes both
T3164 3928-3931 DT denotes the
T3163 3932-3938 NN denotes genome
T3166 3939-3942 CC denotes and
T3167 3943-3956 NN denotes transcriptome
T3165 3957-3963 NNS denotes levels
T3168 3963-3964 . denotes .
T3169 3964-4151 sentence denotes At the genome level, F2 progeny of the CIA susceptible (DBA/1) and resistant (FVB/N) strains were generated and a genome-wide linkage analysis was performed to identify small-effect QTL.
T3170 3965-3967 IN denotes At
T3172 3968-3971 DT denotes the
T3174 3972-3978 NN denotes genome
T3173 3979-3984 NN denotes level
T3175 3984-3986 , denotes ,
T3176 3986-3988 NN denotes F2
T3177 3989-3996 NN denotes progeny
T3178 3997-3999 IN denotes of
T3179 4000-4003 DT denotes the
T3181 4004-4007 NN denotes CIA
T3182 4008-4019 JJ denotes susceptible
T3183 4020-4021 -LRB- denotes (
T3184 4021-4024 NN denotes DBA
T3185 4024-4025 HYPH denotes /
T3186 4025-4026 CD denotes 1
T3187 4026-4027 -RRB- denotes )
T3188 4028-4031 CC denotes and
T3189 4032-4041 JJ denotes resistant
T3190 4042-4043 -LRB- denotes (
T3192 4043-4046 NN denotes FVB
T3193 4046-4047 HYPH denotes /
T3191 4047-4048 NN denotes N
T3194 4048-4049 -RRB- denotes )
T3180 4050-4057 NNS denotes strains
T3195 4058-4062 VBD denotes were
T3171 4063-4072 VBN denotes generated
T3196 4073-4076 CC denotes and
T3197 4077-4078 DT denotes a
T3199 4079-4085 NN denotes genome
T3201 4085-4086 HYPH denotes -
T3200 4086-4090 JJ denotes wide
T3202 4091-4098 NN denotes linkage
T3198 4099-4107 NN denotes analysis
T3204 4108-4111 VBD denotes was
T3203 4112-4121 VBN denotes performed
T3205 4122-4124 TO denotes to
T3206 4125-4133 VB denotes identify
T3207 4134-4139 JJ denotes small
T3209 4139-4140 HYPH denotes -
T3208 4140-4146 NN denotes effect
T3210 4147-4150 NN denotes QTL
T3211 4150-4151 . denotes .
T3212 4151-4289 sentence denotes At the transcriptome level, we detected the gene expression patterns of both the DBA/1 and FVB/N strains at four different phases of CIA.
T3213 4152-4154 IN denotes At
T3215 4155-4158 DT denotes the
T3217 4159-4172 NN denotes transcriptome
T3216 4173-4178 NN denotes level
T3218 4178-4180 , denotes ,
T3219 4180-4182 PRP denotes we
T3214 4183-4191 VBD denotes detected
T3220 4192-4195 DT denotes the
T3222 4196-4200 NN denotes gene
T3223 4201-4211 NN denotes expression
T3221 4212-4220 NNS denotes patterns
T3224 4221-4223 IN denotes of
T3225 4224-4228 CC denotes both
T3227 4229-4232 DT denotes the
T3228 4233-4236 NN denotes DBA
T3229 4236-4237 HYPH denotes /
T3230 4237-4238 CD denotes 1
T3231 4239-4242 CC denotes and
T3232 4243-4246 NN denotes FVB
T3234 4246-4247 HYPH denotes /
T3233 4247-4248 NN denotes N
T3226 4249-4256 NNS denotes strains
T3235 4257-4259 IN denotes at
T3236 4260-4264 CD denotes four
T3238 4265-4274 JJ denotes different
T3237 4275-4281 NNS denotes phases
T3239 4282-4284 IN denotes of
T3240 4285-4288 NN denotes CIA
T3241 4288-4289 . denotes .
T3242 4289-4580 sentence denotes The potential candidate genes were identified based on three criteria: they are located within the genomic region linked to CIA; they are disease-specific differentially expressed during CIA; and they are strain-specific differentially expressed between the two parental strains during CIA.
T3243 4290-4293 DT denotes The
T3245 4294-4303 JJ denotes potential
T3246 4304-4313 NN denotes candidate
T3244 4314-4319 NNS denotes genes
T3248 4320-4324 VBD denotes were
T3247 4325-4335 VBN denotes identified
T3250 4336-4341 VBN denotes based
T3251 4342-4344 IN denotes on
T3252 4345-4350 CD denotes three
T3253 4351-4359 NNS denotes criteria
T3254 4359-4361 : denotes :
T3255 4361-4365 PRP denotes they
T3256 4366-4369 VBP denotes are
T3249 4370-4377 VBN denotes located
T3257 4378-4384 IN denotes within
T3258 4385-4388 DT denotes the
T3260 4389-4396 JJ denotes genomic
T3259 4397-4403 NN denotes region
T3261 4404-4410 VBN denotes linked
T3262 4411-4413 IN denotes to
T3263 4414-4417 NN denotes CIA
T3264 4417-4418 : denotes ;
T3265 4419-4423 PRP denotes they
T3267 4424-4427 VBP denotes are
T3268 4428-4435 NN denotes disease
T3270 4435-4436 HYPH denotes -
T3269 4436-4444 RB denotes specific
T3271 4445-4459 RB denotes differentially
T3266 4460-4469 VBN denotes expressed
T3272 4470-4476 IN denotes during
T3273 4477-4480 NN denotes CIA
T3274 4480-4481 : denotes ;
T3275 4482-4485 CC denotes and
T3276 4486-4490 PRP denotes they
T3278 4491-4494 VBP denotes are
T3279 4495-4501 NN denotes strain
T3281 4501-4502 HYPH denotes -
T3280 4502-4510 RB denotes specific
T3282 4511-4525 RB denotes differentially
T3277 4526-4535 VBN denotes expressed
T3283 4536-4543 IN denotes between
T3284 4544-4547 DT denotes the
T3286 4548-4551 CD denotes two
T3287 4552-4560 JJ denotes parental
T3285 4561-4568 NNS denotes strains
T3288 4569-4575 IN denotes during
T3289 4576-4579 NN denotes CIA
T3290 4579-4580 . denotes .
R1000 T3269 T3266 advmod specific,expressed
R1001 T3270 T3269 punct -,specific
R1002 T3271 T3266 advmod differentially,expressed
R1003 T3272 T3266 prep during,expressed
R1004 T3273 T3272 pobj CIA,during
R1005 T3274 T3266 punct ;,expressed
R1006 T3275 T3266 cc and,expressed
R1007 T3276 T3277 nsubjpass they,expressed
R1008 T3277 T3266 conj expressed,expressed
R1009 T3278 T3277 auxpass are,expressed
R1010 T3279 T3280 npadvmod strain,specific
R1011 T3280 T3277 advmod specific,expressed
R1012 T3281 T3280 punct -,specific
R1013 T3282 T3277 advmod differentially,expressed
R1014 T3283 T3277 prep between,expressed
R1015 T3284 T3285 det the,strains
R1016 T3285 T3283 pobj strains,between
R1017 T3286 T3285 nummod two,strains
R1018 T3287 T3285 amod parental,strains
R1019 T3288 T3277 prep during,expressed
R1020 T3289 T3288 pobj CIA,during
R1021 T3290 T3249 punct .,located
R210 T2422 T2423 nsubjpass Susceptibility,controlled
R211 T2424 T2422 prep to,Susceptibility
R212 T2425 T2426 advmod most,diseases
R213 T2426 T2424 pobj diseases,to
R214 T2427 T2426 amod complex,diseases
R215 T2428 T2423 auxpass is,controlled
R216 T2429 T2423 agent by,controlled
R217 T2430 T2431 amod many,genes
R218 T2431 T2429 pobj genes,by
R219 T2432 T2431 punct ", ",genes
R220 T2433 T2434 advmod each,having
R221 T2434 T2431 acl having,genes
R222 T2435 T2436 det a,effect
R223 T2436 T2434 dobj effect,having
R224 T2437 T2436 amod small,effect
R225 T2438 T2436 prep on,effect
R226 T2439 T2440 det the,disease
R227 T2440 T2438 pobj disease,on
R228 T2441 T2423 punct .,controlled
R229 T2443 T2444 nummod One,example
R230 T2444 T2445 nsubj example,is
R231 T2446 T2447 amod rheumatoid,arthritis
R232 T2447 T2445 attr arthritis,is
R233 T2448 T2447 punct (,arthritis
R234 T2449 T2447 appos RA,arthritis
R235 T2450 T2447 punct ),arthritis
R236 T2451 T2447 punct ", ",arthritis
R237 T2452 T2453 det a,disease
R238 T2453 T2447 appos disease,arthritis
R239 T2454 T2453 amod common,disease
R240 T2455 T2453 nmod complex,disease
R241 T2456 T2453 amod multifactorial,disease
R242 T2457 T2453 amod autoimmune,disease
R243 T2458 T2445 punct .,is
R244 T2460 T2461 amod Several,studies
R245 T2461 T2462 nsubjpass studies,carried
R246 T2463 T2462 aux have,carried
R247 T2464 T2462 auxpass been,carried
R248 T2465 T2462 prt out,carried
R249 T2466 T2467 aux to,detect
R250 T2467 T2462 advcl detect,carried
R251 T2468 T2469 det the,basis
R252 T2469 T2467 dobj basis,detect
R253 T2470 T2469 amod genetic,basis
R254 T2471 T2469 prep of,basis
R255 T2472 T2471 pobj RA,of
R256 T2473 T2462 punct ", ",carried
R257 T2474 T2462 cc and,carried
R258 T2475 T2476 amod more,30
R259 T2476 T2478 nummod 30,regions
R260 T2477 T2476 quantmod than,30
R261 T2478 T2480 nsubj regions,shown
R262 T2479 T2478 amod genomic,regions
R263 T2480 T2462 conj shown,carried
R264 T2481 T2480 aux have,shown
R265 T2482 T2480 dobj evidence,shown
R266 T2483 T2482 prep of,evidence
R267 T2484 T2483 pobj linkage,of
R268 T2485 T2484 prep to,linkage
R269 T2486 T2487 det the,disease
R270 T2487 T2485 pobj disease,to
R271 T2488 T2480 punct .,shown
R272 T2490 T2491 nsubj Most,reach
R273 T2492 T2490 prep of,Most
R274 T2493 T2494 det these,regions
R275 T2494 T2492 pobj regions,of
R276 T2495 T2494 amod genomic,regions
R277 T2496 T2491 aux did,reach
R278 T2497 T2491 neg not,reach
R279 T2498 T2499 det a,value
R280 T2499 T2491 dobj value,reach
R281 T2500 T2501 npadvmod genome,wide
R282 T2501 T2499 amod wide,value
R283 T2502 T2501 punct -,wide
R284 T2503 T2499 amod significant,value
R285 T2504 T2499 compound threshold,value
R286 T2505 T2499 prep of,value
R287 T2506 T2505 pobj linkage,of
R288 T2507 T2499 punct ", ",value
R289 T2508 T2499 prep with,value
R290 T2509 T2510 compound P,values
R291 T2510 T2508 pobj values,with
R292 T2511 T2510 prep between,values
R293 T2512 T2511 pobj 0.05,between
R294 T2513 T2512 cc and,0.05
R295 T2514 T2512 conj 0.001,0.05
R296 T2515 T2516 punct [,1
R297 T2516 T2491 parataxis 1,reach
R298 T2517 T2518 punct -,5
R299 T2518 T2516 prep 5,1
R300 T2519 T2516 punct ],1
R301 T2520 T2491 punct .,reach
R302 T2522 T2523 advmod Thus,have
R303 T2524 T2523 punct ", ",have
R304 T2525 T2526 det these,loci
R305 T2526 T2523 nsubj loci,have
R306 T2527 T2523 advmod only,have
R307 T2528 T2529 det a,effect
R308 T2529 T2523 dobj effect,have
R309 T2530 T2529 amod small,effect
R310 T2531 T2529 prep on,effect
R311 T2532 T2531 pobj RA,on
R312 T2533 T2523 punct .,have
R313 T2535 T2536 amod Small,contributions
R314 T2536 T2538 nsubjpass contributions,seen
R315 T2537 T2536 amod genetic,contributions
R316 T2539 T2538 aux could,seen
R317 T2540 T2538 advmod also,seen
R318 T2541 T2538 auxpass be,seen
R319 T2542 T2538 prep from,seen
R320 T2543 T2544 det the,genes
R321 T2544 T2542 pobj genes,from
R322 T2545 T2544 compound susceptibility,genes
R323 T2546 T2544 prep of,genes
R324 T2547 T2546 pobj RA,of
R325 T2548 T2544 acl identified,genes
R326 T2549 T2550 advmod so,far
R327 T2550 T2548 advmod far,identified
R328 T2551 T2544 punct ", ",genes
R329 T2552 T2544 prep including,genes
R330 T2553 T2554 compound HLA,DR4
R331 T2554 T2552 pobj DR4,including
R332 T2555 T2554 punct -,DR4
R333 T2556 T2554 punct ", ",DR4
R334 T2557 T2554 conj PADI4,DR4
R335 T2558 T2557 punct ", ",PADI4
R336 T2559 T2557 conj PTPN22,PADI4
R337 T2560 T2559 cc and,PTPN22
R338 T2561 T2559 conj FCRL3,PTPN22
R339 T2562 T2563 punct [,6
R340 T2563 T2538 parataxis 6,seen
R341 T2564 T2565 punct -,9
R342 T2565 T2563 prep 9,6
R343 T2566 T2563 punct ],6
R344 T2567 T2538 punct .,seen
R345 T2569 T2570 prep Except,have
R346 T2571 T2569 prep for,Except
R347 T2572 T2573 compound HLA,DR4
R348 T2573 T2571 pobj DR4,for
R349 T2574 T2573 punct -,DR4
R350 T2575 T2573 punct ", ",DR4
R351 T2576 T2577 dep which,associated
R352 T2577 T2573 relcl associated,DR4
R353 T2578 T2577 auxpass is,associated
R354 T2579 T2577 advmod strongly,associated
R355 T2580 T2577 prep with,associated
R356 T2581 T2580 pobj RA,with
R357 T2582 T2570 punct ", ",have
R358 T2583 T2584 predet all,genes
R359 T2584 T2570 nsubj genes,have
R360 T2585 T2584 det the,genes
R361 T2586 T2584 amod other,genes
R362 T2587 T2584 compound susceptibility,genes
R363 T2588 T2589 advmod only,effect
R364 T2589 T2570 dobj effect,have
R365 T2590 T2589 det a,effect
R366 T2591 T2589 amod small,effect
R367 T2592 T2589 prep on,effect
R368 T2593 T2594 det the,disease
R369 T2660 T2657 punct ", ",QTL
R370 T2594 T2592 pobj disease,on
R371 T2661 T2657 appos Cia2,QTL
R372 T2595 T2570 punct .,have
R373 T2662 T2659 punct ", ",identified
R374 T2663 T2659 auxpass was,identified
R375 T2597 T2598 prep In,observed
R376 T2664 T2659 prep for,identified
R377 T2665 T2666 det the,phenotype
R378 T2666 T2664 pobj phenotype,for
R379 T2599 T2600 det the,model
R380 T2667 T2666 prep of,phenotype
R381 T2668 T2669 compound CIA,severity
R382 T2669 T2667 pobj severity,of
R383 T2670 T2659 punct ", ",identified
R384 T2600 T2597 pobj model,In
R385 T2671 T2659 cc but,identified
R386 T2672 T2673 det this,QTL
R387 T2673 T2674 nsubj QTL,contributes
R388 T2674 T2659 conj contributes,identified
R389 T2601 T2600 compound mouse,model
R390 T2675 T2674 prep to,contributes
R391 T2676 T2677 advmod only,16
R392 T2602 T2600 prep of,model
R393 T2677 T2678 nummod 16,%
R394 T2678 T2675 pobj %,to
R395 T2679 T2678 prep of,%
R396 T2603 T2602 pobj RA,of
R397 T2680 T2681 det the,variations
R398 T2681 T2679 pobj variations,of
R399 T2682 T2681 compound phenotype,variations
R400 T2604 T2598 punct ", ",observed
R401 T2683 T2681 prep for,variations
R402 T2684 T2685 compound CIA,susceptibility
R403 T2685 T2683 pobj susceptibility,for
R404 T2605 T2606 amod small,contributions
R405 T2686 T2674 prep in,contributes
R406 T2687 T2688 compound F2,progeny
R407 T2606 T2598 nsubjpass contributions,observed
R408 T2688 T2686 pobj progeny,in
R409 T2607 T2606 amod genetic,contributions
R410 T2608 T2598 auxpass are,observed
R411 T2689 T2690 punct [,10
R412 T2609 T2610 advmod also,often
R413 T2690 T2674 parataxis 10,contributes
R414 T2691 T2690 punct ],10
R415 T2692 T2674 punct .,contributes
R416 T2610 T2598 advmod often,observed
R417 T2694 T2695 nsubj This,suggests
R418 T2696 T2697 mark that,be
R419 T2697 T2695 ccomp be,suggests
R420 T2698 T2697 expl there,be
R421 T2611 T2598 punct .,observed
R422 T2699 T2697 aux must,be
R423 T2700 T2701 amod other,genes
R424 T2613 T2614 prep For,carried
R425 T2701 T2697 attr genes,be
R426 T2702 T2701 compound susceptibility,genes
R427 T2703 T2704 poss whose,contributions
R428 T2704 T2705 dep contributions,were
R429 T2705 T2701 relcl were,genes
R430 T2615 T2613 pobj example,For
R431 T2706 T2705 neg not,were
R432 T2707 T2705 acomp big,were
R433 T2708 T2707 advmod enough,big
R434 T2616 T2614 punct ", ",carried
R435 T2709 T2710 aux to,reach
R436 T2710 T2707 xcomp reach,big
R437 T2711 T2712 det the,value
R438 T2617 T2614 prep in,carried
R439 T2712 T2710 dobj value,reach
R440 T2713 T2712 amod stringent,value
R441 T2714 T2712 compound significance,value
R442 T2715 T2712 compound threshold,value
R443 T2618 T2619 det a,study
R444 T2716 T2712 prep of,value
R445 T2717 T2718 compound linkage,analysis
R446 T2619 T2617 pobj study,in
R447 T2718 T2716 pobj analysis,of
R448 T2719 T2695 punct .,suggests
R449 T2620 T2619 amod previous,study
R450 T2721 T2722 nummod One,aim
R451 T2722 T2723 nsubj aim,is
R452 T2621 T2614 punct ", ",carried
R453 T2724 T2722 prep of,aim
R454 T2725 T2724 pcomp using,of
R455 T2622 T2614 nsubj we,carried
R456 T2726 T2727 compound animal,models
R457 T2727 T2725 dobj models,using
R458 T2728 T2725 prep for,using
R459 T2623 T2614 prt out,carried
R460 T2729 T2730 amod complex,diseases
R461 T2730 T2728 pobj diseases,for
R462 T2624 T2625 det a,screen
R463 T2731 T2732 aux to,detect
R464 T2732 T2723 xcomp detect,is
R465 T2625 T2614 dobj screen,carried
R466 T2733 T2734 det the,basis
R467 T2734 T2732 dobj basis,detect
R468 T2735 T2734 amod genetic,basis
R469 T2736 T2734 prep of,basis
R470 T2737 T2738 det these,diseases
R471 T2738 T2736 pobj diseases,of
R472 T2739 T2723 punct .,is
R473 T2626 T2625 compound genome,screen
R474 T2741 T2742 prep With,are
R475 T2627 T2628 aux to,identify
R476 T2743 T2744 amod controllable,factors
R477 T2744 T2741 pobj factors,With
R478 T2628 T2614 advcl identify,carried
R479 T2745 T2744 amod environmental,factors
R480 T2746 T2747 advmod as,as
R481 T2747 T2744 cc as,factors
R482 T2629 T2630 det the,loci
R483 T2748 T2747 advmod well,as
R484 T2749 T2750 det the,background
R485 T2750 T2744 conj background,factors
R486 T2630 T2628 dobj loci,identify
R487 T2751 T2750 amod known,background
R488 T2752 T2750 amod genetic,background
R489 T2753 T2742 punct ", ",are
R490 T2631 T2632 amod quantitative,trait
R491 T2754 T2755 compound animal,models
R492 T2755 T2742 nsubj models,are
R493 T2756 T2757 amod powerful,tools
R494 T2632 T2630 compound trait,loci
R495 T2633 T2630 punct (,loci
R496 T2757 T2742 attr tools,are
R497 T2634 T2630 appos QTL,loci
R498 T2758 T2759 aux to,search
R499 T2759 T2757 advcl search,tools
R500 T2635 T2628 punct ),identify
R501 T2760 T2759 prep for,search
R502 T2761 T2762 compound susceptibility,genes
R503 T2762 T2760 pobj genes,for
R504 T2636 T2628 prep in,identify
R505 T2763 T2762 prep for,genes
R506 T2764 T2765 amod complex,diseases
R507 T2765 T2763 pobj diseases,for
R508 T2637 T2638 npadvmod collagen,induced
R509 T2638 T2640 amod induced,arthritis
R510 T2639 T2638 punct -,induced
R511 T2640 T2636 pobj arthritis,in
R512 T2766 T2742 punct ", ",are
R513 T2767 T2742 cc and,are
R514 T2768 T2769 aux have,employed
R515 T2641 T2640 punct (,arthritis
R516 T2769 T2742 conj employed,are
R517 T2770 T2769 auxpass been,employed
R518 T2642 T2640 appos CIA,arthritis
R519 T2771 T2769 advmod intensively,employed
R520 T2772 T2769 prep for,employed
R521 T2773 T2774 det that,purpose
R522 T2774 T2772 pobj purpose,for
R523 T2775 T2742 punct .,are
R524 T2643 T2640 punct ),arthritis
R525 T2644 T2640 punct ", ",arthritis
R526 T2777 T2778 amod More,"27,000"
R527 T2778 T2780 nummod "27,000",QTL
R528 T2779 T2778 quantmod than,"27,000"
R529 T2645 T2646 dep which,is
R530 T2780 T2781 nsubjpass QTL,identified
R531 T2646 T2640 relcl is,arthritis
R532 T2782 T2781 aux have,identified
R533 T2783 T2781 auxpass been,identified
R534 T2784 T2781 prep in,identified
R535 T2647 T2648 det a,model
R536 T2785 T2786 det the,genome
R537 T2786 T2784 pobj genome,in
R538 T2648 T2646 attr model,is
R539 T2787 T2786 compound mouse,genome
R540 T2788 T2789 mark since,identified
R541 T2789 T2781 advcl identified,identified
R542 T2649 T2650 advmod widely,used
R543 T2790 T2791 det the,QTL
R544 T2791 T2789 nsubjpass QTL,identified
R545 T2792 T2791 amod first,QTL
R546 T2650 T2648 amod used,model
R547 T2793 T2789 auxpass was,identified
R548 T2794 T2789 prep at,identified
R549 T2651 T2648 compound animal,model
R550 T2795 T2796 det the,beginning
R551 T2796 T2794 pobj beginning,at
R552 T2797 T2796 prep of,beginning
R553 T2798 T2799 det the,1990s
R554 T2652 T2648 prep of,model
R555 T2799 T2797 pobj 1990s,of
R556 T2800 T2801 punct [,11
R557 T2653 T2652 pobj RA,of
R558 T2801 T2781 parataxis 11,identified
R559 T2802 T2801 punct ],11
R560 T2803 T2781 punct .,identified
R561 T2654 T2614 punct .,carried
R562 T2805 T2806 prep By,identified
R563 T2656 T2657 advmod Only,QTL
R564 T2807 T2805 pobj 2005,By
R565 T2808 T2806 punct ", ",identified
R566 T2809 T2810 advmod approximately,20
R567 T2810 T2811 nummod 20,genes
R568 T2657 T2659 nsubjpass QTL,identified
R569 T2811 T2806 nsubjpass genes,identified
R570 T2812 T2813 amod quantitative,trait
R571 T2813 T2811 compound trait,genes
R572 T2658 T2657 nummod one,QTL
R573 T2814 T2811 punct (,genes
R574 T2815 T2811 appos QTGs,genes
R575 T2816 T2811 punct ),genes
R576 T2817 T2811 prep in,genes
R577 T2818 T2819 det the,genome
R578 T2819 T2817 pobj genome,in
R579 T2872 T2873 amod small,effect
R580 T2820 T2819 compound mouse,genome
R581 T2821 T2806 aux had,identified
R582 T2822 T2806 auxpass been,identified
R583 T2823 T2824 punct [,13
R584 T2824 T2806 parataxis 13,identified
R585 T2825 T2824 nummod 12,13
R586 T2873 T2875 compound effect,QTL
R587 T2826 T2824 punct ",",13
R588 T2827 T2824 punct ],13
R589 T2828 T2806 punct .,identified
R590 T2874 T2873 punct -,effect
R591 T2830 T2831 advmod Interestingly,have
R592 T2875 T2866 nsubj QTL,are
R593 T2832 T2831 punct ", ",have
R594 T2833 T2834 amod most,QTGs
R595 T2876 T2866 acomp difficult,are
R596 T2834 T2831 nsubj QTGs,have
R597 T2835 T2834 acl identified,QTGs
R598 T2877 T2878 aux to,identify
R599 T2836 T2835 prep in,identified
R600 T2837 T2838 compound animal,models
R601 T2838 T2836 pobj models,in
R602 T2878 T2876 advcl identify,difficult
R603 T2839 T2840 det the,polymorphisms
R604 T2840 T2831 dobj polymorphisms,have
R605 T2879 T2878 prep with,identify
R606 T2841 T2840 amod causal,polymorphisms
R607 T2842 T2840 prep in,polymorphisms
R608 T2843 T2844 det the,region
R609 T2880 T2881 amod traditional,strategies
R610 T2844 T2842 pobj region,in
R611 T2845 T2846 npadvmod protein,coding
R612 T2846 T2844 amod coding,region
R613 T2881 T2879 pobj strategies,with
R614 T2847 T2846 punct -,coding
R615 T2848 T2849 punct [,14
R616 T2849 T2844 parataxis 14,region
R617 T2882 T2866 cc and,are
R618 T2850 T2849 punct ],14
R619 T2851 T2840 punct ", ",polymorphisms
R620 T2852 T2853 dep which,provoke
R621 T2883 T2866 punct ", ",are
R622 T2853 T2840 relcl provoke,polymorphisms
R623 T2854 T2855 compound protein,changes
R624 T2884 T2885 prep on,affect
R625 T2855 T2853 dobj changes,provoke
R626 T2856 T2855 compound structure,changes
R627 T2857 T2855 cc or,changes
R628 T2858 T2859 compound protein,deficiency
R629 T2859 T2855 conj deficiency,changes
R630 T2860 T2831 punct .,have
R631 T2885 T2866 conj affect,are
R632 T2862 T2863 nsubj This,suggests
R633 T2886 T2887 det the,hand
R634 T2864 T2863 punct ", ",suggests
R635 T2887 T2884 pobj hand,on
R636 T2865 T2866 prep on,are
R637 T2888 T2887 amod other,hand
R638 T2866 T2863 advcl are,suggests
R639 T2867 T2868 det the,hand
R640 T2889 T2885 punct ", ",affect
R641 T2868 T2865 pobj hand,on
R642 T2869 T2868 nummod one,hand
R643 T2870 T2866 punct ", ",are
R644 T2890 T2885 mark that,affect
R645 T2871 T2866 mark that,are
R646 T2891 T2892 det the,polymorphisms
R647 T2892 T2885 nsubj polymorphisms,affect
R648 T2893 T2892 acl regulating,polymorphisms
R649 T2894 T2895 compound gene,expression
R650 T2978 T2977 amod past,decade
R651 T2979 T2975 punct ", ",applied
R652 T2895 T2893 dobj expression,regulating
R653 T2980 T2981 amod many,studies
R654 T2981 T2975 nsubj studies,applied
R655 T2896 T2885 aux might,affect
R656 T2982 T2983 det this,technique
R657 T2983 T2975 dobj technique,applied
R658 T2897 T2898 advmod only,slightly
R659 T2984 T2985 aux to,study
R660 T2985 T2975 advcl study,applied
R661 T2986 T2987 preconj both,RA
R662 T2987 T2985 dobj RA,study
R663 T2898 T2885 advmod slightly,affect
R664 T2988 T2987 cc and,RA
R665 T2989 T2990 poss its,models
R666 T2899 T2900 det the,traits
R667 T2990 T2987 conj models,RA
R668 T2991 T2990 compound animal,models
R669 T2992 T2993 punct [,15
R670 T2900 T2885 dobj traits,affect
R671 T2993 T2975 parataxis 15,applied
R672 T2994 T2995 punct -,22
R673 T2995 T2993 prep 22,15
R674 T2901 T2900 amod quantitative,traits
R675 T2996 T2993 punct ],15
R676 T2997 T2975 punct .,applied
R677 T2902 T2885 punct ", ",affect
R678 T2999 T3000 advmod Indeed,show
R679 T3001 T3000 punct ", ",show
R680 T3002 T3000 nsubj genes,show
R681 T3003 T3002 acl involved,genes
R682 T2903 T2885 cc and,affect
R683 T3004 T3003 prep in,involved
R684 T3005 T3004 pobj arthritis,in
R685 T3006 T3007 amod distinct,patterns
R686 T3007 T3000 dobj patterns,show
R687 T2904 T2905 advmod thus,are
R688 T3008 T3007 compound expression,patterns
R689 T3009 T3007 prep in,patterns
R690 T3010 T3011 amod certain,tissues
R691 T2905 T2885 conj are,affect
R692 T3011 T3009 pobj tissues,in
R693 T3012 T3011 cc and,tissues
R694 T3013 T3014 amod pathological,stages
R695 T2906 T2907 advmod more,difficult
R696 T3014 T3011 conj stages,tissues
R697 T3015 T3014 prep of,stages
R698 T3016 T3017 det the,disease
R699 T2907 T2905 acomp difficult,are
R700 T3017 T3015 pobj disease,of
R701 T3018 T3000 punct .,show
R702 T2908 T2909 aux to,identify
R703 T3020 T3021 nsubjpass Genes,expressed
R704 T2909 T2907 advcl identify,difficult
R705 T3022 T3020 acl involved,Genes
R706 T3023 T3022 prep in,involved
R707 T3024 T3025 amod immunoinflammatory,responses
R708 T3025 T3023 pobj responses,in
R709 T2910 T2863 punct .,suggests
R710 T3026 T3021 auxpass were,expressed
R711 T3027 T3021 advmod differentially,expressed
R712 T3028 T3021 prep in,expressed
R713 T2912 T2913 npadvmod Microarray,based
R714 T3029 T3030 det the,cells
R715 T3030 T3028 pobj cells,in
R716 T3031 T3030 compound blood,cells
R717 T3032 T3021 prep in,expressed
R718 T2913 T2915 amod based,expression
R719 T3033 T3034 compound RA,patients
R720 T3034 T3032 pobj patients,in
R721 T3035 T3036 punct [,18
R722 T2914 T2913 punct -,based
R723 T3036 T3021 parataxis 18,expressed
R724 T3037 T3036 punct ],18
R725 T3038 T3021 punct .,expressed
R726 T2915 T2918 nsubj expression,is
R727 T2916 T2915 amod global,expression
R728 T2917 T2915 compound gene,expression
R729 T3040 T3041 nsubjpass Chemokines,upregulated
R730 T2919 T2920 det a,technique
R731 T3042 T3040 cc and,Chemokines
R732 T3043 T3044 compound adhesion,molecules
R733 T3044 T3040 conj molecules,Chemokines
R734 T3045 T3041 auxpass were,upregulated
R735 T3046 T3041 prep in,upregulated
R736 T3047 T3048 det the,joint
R737 T3048 T3046 pobj joint,in
R738 T2920 T2918 attr technique,is
R739 T3049 T3041 prep at,upregulated
R740 T3050 T3051 det the,phase
R741 T3051 T3049 pobj phase,at
R742 T2921 T2920 amod powerful,technique
R743 T3052 T3051 compound initiation,phase
R744 T2922 T2920 prep for,technique
R745 T3053 T3051 prep of,phase
R746 T3054 T3053 pobj arthritis,of
R747 T3055 T3041 prep in,upregulated
R748 T3056 T3057 compound animal,models
R749 T2923 T2922 pcomp investigating,for
R750 T3057 T3055 pobj models,in
R751 T3058 T3059 punct [,22
R752 T3059 T3041 parataxis 22,upregulated
R753 T2924 T2925 amod complex,diseases
R754 T3060 T3059 nummod 21,22
R755 T3061 T3059 punct ",",22
R756 T3062 T3059 punct ],22
R757 T2925 T2923 dobj diseases,investigating
R758 T3063 T3041 punct ", ",upregulated
R759 T3064 T3065 mark while,expressed
R760 T2926 T2918 punct .,is
R761 T3065 T3041 advcl expressed,upregulated
R762 T3066 T3065 nsubjpass genes,expressed
R763 T3067 T3066 acl involved,genes
R764 T3068 T3067 prep in,involved
R765 T2928 T2929 prep During,are
R766 T3069 T3070 compound cartilage,destruction
R767 T3070 T3068 pobj destruction,in
R768 T3071 T3070 cc and,destruction
R769 T3072 T3073 compound bone,erosion
R770 T2930 T2931 compound disease,development
R771 T3073 T3070 conj erosion,destruction
R772 T3074 T3065 auxpass were,expressed
R773 T3075 T3065 advmod differentially,expressed
R774 T3076 T3065 prep at,expressed
R775 T2931 T2928 pobj development,During
R776 T3077 T3078 det the,phase
R777 T3078 T3076 pobj phase,at
R778 T3079 T3078 amod late,phase
R779 T2932 T2929 punct ", ",are
R780 T3080 T3078 prep of,phase
R781 T3081 T3080 pobj arthritis,of
R782 T3082 T3065 prep in,expressed
R783 T2933 T2929 nsubj genes,are
R784 T3083 T3084 compound animal,models
R785 T2934 T2933 acl involved,genes
R786 T2935 T2934 prep in,involved
R787 T3084 T3082 pobj models,in
R788 T2936 T2937 det the,disease
R789 T3085 T3084 prep of,models
R790 T3086 T3085 pobj RA,of
R791 T3087 T3088 punct [,16
R792 T2937 T2935 pobj disease,in
R793 T3088 T3065 parataxis 16,expressed
R794 T3089 T3088 nummod 15,16
R795 T2938 T2929 acomp likely,are
R796 T3090 T3088 punct ",",16
R797 T2939 T2940 aux to,regulated
R798 T3091 T3088 punct ],16
R799 T3092 T3041 punct .,upregulated
R800 T3094 T3095 mark Besides,detecting
R801 T2940 T2938 xcomp regulated,likely
R802 T3095 T3096 advcl detecting,used
R803 T2941 T2940 auxpass be,regulated
R804 T3097 T3095 dobj genes,detecting
R805 T3098 T3097 acl involved,genes
R806 T3099 T3098 prep in,involved
R807 T2942 T2940 advmod differentially,regulated
R808 T3100 T3101 amod complex,diseases
R809 T3101 T3099 pobj diseases,in
R810 T3102 T3096 punct ", ",used
R811 T3103 T3096 nsubjpass microarrays,used
R812 T2943 T2929 punct .,are
R813 T3104 T3096 aux could,used
R814 T3105 T3096 advmod also,used
R815 T3106 T3096 auxpass be,used
R816 T2945 T2946 advmod Therefore,identified
R817 T3107 T3108 aux to,detect
R818 T3108 T3096 advcl detect,used
R819 T3109 T3110 det the,polymorphisms
R820 T3110 T3108 dobj polymorphisms,detect
R821 T2947 T2946 punct ", ",identified
R822 T3111 T3110 amod genetic,polymorphisms
R823 T3112 T3110 acl regulating,polymorphisms
R824 T3113 T3114 compound gene,expression
R825 T3114 T3112 dobj expression,regulating
R826 T3115 T3116 mark because,be
R827 T2948 T2949 compound signature,genes
R828 T3116 T3108 advcl be,detect
R829 T3117 T3118 amod differential,expressions
R830 T2949 T2946 nsubjpass genes,identified
R831 T3118 T3116 nsubj expressions,be
R832 T3119 T3118 prep between,expressions
R833 T3120 T3121 nummod two,strains
R834 T2950 T2949 prep of,genes
R835 T3121 T3119 pobj strains,between
R836 T3122 T3116 aux might,be
R837 T3123 T3124 det the,result
R838 T3124 T3116 attr result,be
R839 T2951 T2952 det the,diseases
R840 T3125 T3124 prep of,result
R841 T3126 T3127 det a,polymorphism
R842 T3127 T3125 pobj polymorphism,of
R843 T2952 T2950 pobj diseases,of
R844 T3128 T3127 acl located,polymorphism
R845 T3129 T3128 prep in,located
R846 T3130 T3131 amod regulatory,elements
R847 T2953 T2946 aux could,identified
R848 T3131 T3129 pobj elements,in
R849 T3132 T3096 punct .,used
R850 T2954 T2946 auxpass be,identified
R851 T3134 T3135 aux To,identify
R852 T3135 T3136 advcl identify,investigated
R853 T2955 T2946 prep by,identified
R854 T3137 T3138 det the,QTL
R855 T3138 T3135 dobj QTL,identify
R856 T2956 T2955 pcomp detecting,by
R857 T3139 T3140 amod small,effect
R858 T3140 T3138 compound effect,QTL
R859 T3141 T3140 punct -,effect
R860 T3142 T3138 prep of,QTL
R861 T2957 T2958 det the,patterns
R862 T3143 T3142 pobj CIA,of
R863 T3144 T3145 advmod as,as
R864 T3145 T3138 cc as,QTL
R865 T2958 T2956 dobj patterns,detecting
R866 T3146 T3145 advmod well,as
R867 T3147 T3148 det the,genes
R868 T3148 T3138 conj genes,QTL
R869 T2959 T2958 compound expression,patterns
R870 T2960 T2958 prep of,patterns
R871 T3149 T3148 amod potential,genes
R872 T2961 T2962 det the,tissues
R873 T3150 T3148 compound candidate,genes
R874 T3151 T3148 prep inside,genes
R875 T3152 T3151 pobj them,inside
R876 T2962 T2960 pobj tissues,of
R877 T3153 T3136 punct ", ",investigated
R878 T3154 T3136 nsubj we,investigated
R879 T2963 T2964 npadvmod disease,related
R880 T3155 T3156 npadvmod CIA,susceptible
R881 T3156 T3158 amod susceptible,strains
R882 T3157 T3156 advmod genetically,susceptible
R883 T2964 T2962 amod related,tissues
R884 T3158 T3136 dobj strains,investigated
R885 T3159 T3156 cc and,susceptible
R886 T3160 T3156 conj resistant,susceptible
R887 T2965 T2964 punct -,related
R888 T3161 T3136 prep at,investigated
R889 T3162 T3163 preconj both,genome
R890 T3163 T3165 nmod genome,levels
R891 T3164 T3163 det the,genome
R892 T3165 T3161 pobj levels,at
R893 T3166 T3163 cc and,genome
R894 T3167 T3163 conj transcriptome,genome
R895 T2966 T2962 compound cells,tissues
R896 T3168 T3136 punct .,investigated
R897 T3170 T3171 prep At,generated
R898 T2967 T2962 punct /,tissues
R899 T3172 T3173 det the,level
R900 T3173 T3170 pobj level,At
R901 T2968 T2962 cc and,tissues
R902 T3174 T3173 compound genome,level
R903 T2969 T2970 poss their,controls
R904 T3175 T3171 punct ", ",generated
R905 T3176 T3177 compound F2,progeny
R906 T3177 T3171 nsubjpass progeny,generated
R907 T3178 T3177 prep of,progeny
R908 T2970 T2962 conj controls,tissues
R909 T3179 T3180 det the,strains
R910 T3180 T3178 pobj strains,of
R911 T3181 T3180 amod CIA,strains
R912 T2971 T2970 amod ideal,controls
R913 T3182 T3181 amod susceptible,CIA
R914 T3183 T3184 punct (,DBA
R915 T3184 T3182 parataxis DBA,susceptible
R916 T2972 T2946 punct .,identified
R917 T3185 T3184 punct /,DBA
R918 T3186 T3184 nummod 1,DBA
R919 T3187 T3184 punct ),DBA
R920 T2974 T2975 prep In,applied
R921 T3188 T3181 cc and,CIA
R922 T3189 T3181 conj resistant,CIA
R923 T2976 T2977 det the,decade
R924 T2977 T2974 pobj decade,In
R925 T3190 T3191 punct (,N
R926 T3191 T3189 parataxis N,resistant
R927 T3192 T3191 compound FVB,N
R928 T3193 T3191 punct /,N
R929 T3194 T3191 punct ),N
R930 T3195 T3171 auxpass were,generated
R931 T3196 T3171 cc and,generated
R932 T3197 T3198 det a,analysis
R933 T3198 T3203 nsubjpass analysis,performed
R934 T3199 T3200 npadvmod genome,wide
R935 T3200 T3198 amod wide,analysis
R936 T3201 T3200 punct -,wide
R937 T3202 T3198 compound linkage,analysis
R938 T3203 T3171 conj performed,generated
R939 T3204 T3203 auxpass was,performed
R940 T3205 T3206 aux to,identify
R941 T3206 T3203 advcl identify,performed
R942 T3207 T3208 amod small,effect
R943 T3208 T3210 compound effect,QTL
R944 T3209 T3208 punct -,effect
R945 T3210 T3206 dobj QTL,identify
R946 T3211 T3203 punct .,performed
R947 T3213 T3214 prep At,detected
R948 T3215 T3216 det the,level
R949 T3216 T3213 pobj level,At
R950 T3217 T3216 compound transcriptome,level
R951 T3218 T3214 punct ", ",detected
R952 T3219 T3214 nsubj we,detected
R953 T3220 T3221 det the,patterns
R954 T3221 T3214 dobj patterns,detected
R955 T3222 T3223 compound gene,expression
R956 T3223 T3221 compound expression,patterns
R957 T3224 T3221 prep of,patterns
R958 T3225 T3226 preconj both,strains
R959 T3226 T3224 pobj strains,of
R960 T3227 T3226 det the,strains
R961 T3228 T3226 nmod DBA,strains
R962 T3229 T3228 punct /,DBA
R963 T3230 T3228 nummod 1,DBA
R964 T3231 T3228 cc and,DBA
R965 T3232 T3233 compound FVB,N
R966 T3233 T3228 conj N,DBA
R967 T3234 T3233 punct /,N
R968 T3235 T3214 prep at,detected
R969 T3236 T3237 nummod four,phases
R970 T3237 T3235 pobj phases,at
R971 T3238 T3237 amod different,phases
R972 T3239 T3237 prep of,phases
R973 T3240 T3239 pobj CIA,of
R974 T3241 T3214 punct .,detected
R975 T3243 T3244 det The,genes
R976 T3244 T3247 nsubjpass genes,identified
R977 T3245 T3244 amod potential,genes
R978 T3246 T3244 compound candidate,genes
R979 T3247 T3249 ccomp identified,located
R980 T3248 T3247 auxpass were,identified
R981 T3250 T3247 prep based,identified
R982 T3251 T3250 prep on,based
R983 T3252 T3253 nummod three,criteria
R984 T3253 T3251 pobj criteria,on
R985 T3254 T3249 punct : ,located
R986 T3255 T3249 nsubjpass they,located
R987 T3256 T3249 auxpass are,located
R988 T3257 T3249 prep within,located
R989 T3258 T3259 det the,region
R990 T3259 T3257 pobj region,within
R991 T3260 T3259 amod genomic,region
R992 T3261 T3259 acl linked,region
R993 T3262 T3261 prep to,linked
R994 T3263 T3262 pobj CIA,to
R995 T3264 T3249 punct ;,located
R996 T3265 T3266 nsubjpass they,expressed
R997 T3266 T3249 conj expressed,located
R998 T3267 T3266 auxpass are,expressed
R999 T3268 T3269 npadvmod disease,specific