Id |
Subject |
Object |
Predicate |
Lexical cue |
T2422 |
13-27 |
NN |
denotes |
Susceptibility |
T2424 |
28-30 |
IN |
denotes |
to |
T2425 |
31-35 |
RBS |
denotes |
most |
T2427 |
36-43 |
JJ |
denotes |
complex |
T2426 |
44-52 |
NNS |
denotes |
diseases |
T2428 |
53-55 |
VBZ |
denotes |
is |
T2423 |
56-66 |
VBN |
denotes |
controlled |
T2429 |
67-69 |
IN |
denotes |
by |
T2430 |
70-74 |
JJ |
denotes |
many |
T2431 |
75-80 |
NNS |
denotes |
genes |
T2432 |
80-82 |
, |
denotes |
, |
T2433 |
82-86 |
RB |
denotes |
each |
T2434 |
87-93 |
VBG |
denotes |
having |
T2435 |
94-95 |
DT |
denotes |
a |
T2437 |
96-101 |
JJ |
denotes |
small |
T2436 |
102-108 |
NN |
denotes |
effect |
T2438 |
109-111 |
IN |
denotes |
on |
T2439 |
112-115 |
DT |
denotes |
the |
T2440 |
116-123 |
NN |
denotes |
disease |
T2441 |
123-124 |
. |
denotes |
. |
T2442 |
124-218 |
sentence |
denotes |
One example is rheumatoid arthritis (RA), a common complex multifactorial autoimmune disease. |
T2443 |
125-128 |
CD |
denotes |
One |
T2444 |
129-136 |
NN |
denotes |
example |
T2445 |
137-139 |
VBZ |
denotes |
is |
T2446 |
140-150 |
JJ |
denotes |
rheumatoid |
T2447 |
151-160 |
NN |
denotes |
arthritis |
T2448 |
161-162 |
-LRB- |
denotes |
( |
T2449 |
162-164 |
NN |
denotes |
RA |
T2450 |
164-165 |
-RRB- |
denotes |
) |
T2451 |
165-167 |
, |
denotes |
, |
T2452 |
167-168 |
DT |
denotes |
a |
T2454 |
169-175 |
JJ |
denotes |
common |
T2455 |
176-183 |
NN |
denotes |
complex |
T2456 |
184-198 |
JJ |
denotes |
multifactorial |
T2457 |
199-209 |
JJ |
denotes |
autoimmune |
T2453 |
210-217 |
NN |
denotes |
disease |
T2458 |
217-218 |
. |
denotes |
. |
T2459 |
218-371 |
sentence |
denotes |
Several studies have been carried out to detect the genetic basis of RA, and more than 30 genomic regions have shown evidence of linkage to the disease. |
T2460 |
219-226 |
JJ |
denotes |
Several |
T2461 |
227-234 |
NNS |
denotes |
studies |
T2463 |
235-239 |
VBP |
denotes |
have |
T2464 |
240-244 |
VBN |
denotes |
been |
T2462 |
245-252 |
VBN |
denotes |
carried |
T2465 |
253-256 |
RP |
denotes |
out |
T2466 |
257-259 |
TO |
denotes |
to |
T2467 |
260-266 |
VB |
denotes |
detect |
T2468 |
267-270 |
DT |
denotes |
the |
T2470 |
271-278 |
JJ |
denotes |
genetic |
T2469 |
279-284 |
NN |
denotes |
basis |
T2471 |
285-287 |
IN |
denotes |
of |
T2472 |
288-290 |
NN |
denotes |
RA |
T2473 |
290-292 |
, |
denotes |
, |
T2474 |
292-295 |
CC |
denotes |
and |
T2475 |
296-300 |
JJR |
denotes |
more |
T2477 |
301-305 |
IN |
denotes |
than |
T2476 |
306-308 |
CD |
denotes |
30 |
T2479 |
309-316 |
JJ |
denotes |
genomic |
T2478 |
317-324 |
NNS |
denotes |
regions |
T2481 |
325-329 |
VBP |
denotes |
have |
T2480 |
330-335 |
VBN |
denotes |
shown |
T2482 |
336-344 |
NN |
denotes |
evidence |
T2483 |
345-347 |
IN |
denotes |
of |
T2484 |
348-355 |
NN |
denotes |
linkage |
T2485 |
356-358 |
IN |
denotes |
to |
T2486 |
359-362 |
DT |
denotes |
the |
T2487 |
363-370 |
NN |
denotes |
disease |
T2488 |
370-371 |
. |
denotes |
. |
T2489 |
371-513 |
sentence |
denotes |
Most of these genomic regions did not reach a genome-wide significant threshold value of linkage, with P values between 0.05 and 0.001 [1-5]. |
T2490 |
372-376 |
JJS |
denotes |
Most |
T2492 |
377-379 |
IN |
denotes |
of |
T2493 |
380-385 |
DT |
denotes |
these |
T2495 |
386-393 |
JJ |
denotes |
genomic |
T2494 |
394-401 |
NNS |
denotes |
regions |
T2496 |
402-405 |
VBD |
denotes |
did |
T2497 |
406-409 |
RB |
denotes |
not |
T2491 |
410-415 |
VB |
denotes |
reach |
T2498 |
416-417 |
DT |
denotes |
a |
T2500 |
418-424 |
NN |
denotes |
genome |
T2502 |
424-425 |
HYPH |
denotes |
- |
T2501 |
425-429 |
JJ |
denotes |
wide |
T2503 |
430-441 |
JJ |
denotes |
significant |
T2504 |
442-451 |
NN |
denotes |
threshold |
T2499 |
452-457 |
NN |
denotes |
value |
T2505 |
458-460 |
IN |
denotes |
of |
T2506 |
461-468 |
NN |
denotes |
linkage |
T2507 |
468-470 |
, |
denotes |
, |
T2508 |
470-474 |
IN |
denotes |
with |
T2509 |
475-476 |
NN |
denotes |
P |
T2510 |
477-483 |
NNS |
denotes |
values |
T2511 |
484-491 |
IN |
denotes |
between |
T2512 |
492-496 |
CD |
denotes |
0.05 |
T2513 |
497-500 |
CC |
denotes |
and |
T2514 |
501-506 |
CD |
denotes |
0.001 |
T2515 |
507-508 |
-LRB- |
denotes |
[ |
T2516 |
508-509 |
CD |
denotes |
1 |
T2517 |
509-510 |
SYM |
denotes |
- |
T2518 |
510-511 |
CD |
denotes |
5 |
T2519 |
511-512 |
-RRB- |
denotes |
] |
T2520 |
512-513 |
. |
denotes |
. |
T2521 |
513-562 |
sentence |
denotes |
Thus, these loci only have a small effect on RA. |
T2522 |
514-518 |
RB |
denotes |
Thus |
T2524 |
518-520 |
, |
denotes |
, |
T2525 |
520-525 |
DT |
denotes |
these |
T2526 |
526-530 |
NNS |
denotes |
loci |
T2527 |
531-535 |
RB |
denotes |
only |
T2523 |
536-540 |
VBP |
denotes |
have |
T2528 |
541-542 |
DT |
denotes |
a |
T2530 |
543-548 |
JJ |
denotes |
small |
T2529 |
549-555 |
NN |
denotes |
effect |
T2531 |
556-558 |
IN |
denotes |
on |
T2532 |
559-561 |
NN |
denotes |
RA |
T2533 |
561-562 |
. |
denotes |
. |
T2534 |
562-714 |
sentence |
denotes |
Small genetic contributions could also be seen from the susceptibility genes of RA identified so far, including HLA-DR4, PADI4, PTPN22 and FCRL3 [6-9]. |
T2535 |
563-568 |
JJ |
denotes |
Small |
T2537 |
569-576 |
JJ |
denotes |
genetic |
T2536 |
577-590 |
NNS |
denotes |
contributions |
T2539 |
591-596 |
MD |
denotes |
could |
T2540 |
597-601 |
RB |
denotes |
also |
T2541 |
602-604 |
VB |
denotes |
be |
T2538 |
605-609 |
VBN |
denotes |
seen |
T2542 |
610-614 |
IN |
denotes |
from |
T2543 |
615-618 |
DT |
denotes |
the |
T2545 |
619-633 |
NN |
denotes |
susceptibility |
T2544 |
634-639 |
NNS |
denotes |
genes |
T2546 |
640-642 |
IN |
denotes |
of |
T2547 |
643-645 |
NN |
denotes |
RA |
T2548 |
646-656 |
VBN |
denotes |
identified |
T2549 |
657-659 |
RB |
denotes |
so |
T2550 |
660-663 |
RB |
denotes |
far |
T2551 |
663-665 |
, |
denotes |
, |
T2552 |
665-674 |
VBG |
denotes |
including |
T2553 |
675-678 |
NN |
denotes |
HLA |
T2555 |
678-679 |
HYPH |
denotes |
- |
T2554 |
679-682 |
NN |
denotes |
DR4 |
T2556 |
682-684 |
, |
denotes |
, |
T2557 |
684-689 |
NN |
denotes |
PADI4 |
T2558 |
689-691 |
, |
denotes |
, |
T2559 |
691-697 |
NN |
denotes |
PTPN22 |
T2560 |
698-701 |
CC |
denotes |
and |
T2561 |
702-707 |
NN |
denotes |
FCRL3 |
T2562 |
708-709 |
-LRB- |
denotes |
[ |
T2563 |
709-710 |
CD |
denotes |
6 |
T2564 |
710-711 |
SYM |
denotes |
- |
T2565 |
711-712 |
CD |
denotes |
9 |
T2566 |
712-713 |
-RRB- |
denotes |
] |
T2567 |
713-714 |
. |
denotes |
. |
T2568 |
714-848 |
sentence |
denotes |
Except for HLA-DR4, which is strongly associated with RA, all the other susceptibility genes have only a small effect on the disease. |
T2569 |
715-721 |
IN |
denotes |
Except |
T2571 |
722-725 |
IN |
denotes |
for |
T2572 |
726-729 |
NN |
denotes |
HLA |
T2574 |
729-730 |
HYPH |
denotes |
- |
T2573 |
730-733 |
NN |
denotes |
DR4 |
T2575 |
733-735 |
, |
denotes |
, |
T2576 |
735-740 |
WDT |
denotes |
which |
T2578 |
741-743 |
VBZ |
denotes |
is |
T2579 |
744-752 |
RB |
denotes |
strongly |
T2577 |
753-763 |
VBN |
denotes |
associated |
T2580 |
764-768 |
IN |
denotes |
with |
T2581 |
769-771 |
NN |
denotes |
RA |
T2582 |
771-773 |
, |
denotes |
, |
T2583 |
773-776 |
PDT |
denotes |
all |
T2585 |
777-780 |
DT |
denotes |
the |
T2586 |
781-786 |
JJ |
denotes |
other |
T2587 |
787-801 |
NN |
denotes |
susceptibility |
T2584 |
802-807 |
NNS |
denotes |
genes |
T2570 |
808-812 |
VBP |
denotes |
have |
T2588 |
813-817 |
RB |
denotes |
only |
T2590 |
818-819 |
DT |
denotes |
a |
T2591 |
820-825 |
JJ |
denotes |
small |
T2589 |
826-832 |
NN |
denotes |
effect |
T2592 |
833-835 |
IN |
denotes |
on |
T2593 |
836-839 |
DT |
denotes |
the |
T2594 |
840-847 |
NN |
denotes |
disease |
T2595 |
847-848 |
. |
denotes |
. |
T2596 |
848-927 |
sentence |
denotes |
In the mouse model of RA, small genetic contributions are also often observed. |
T2597 |
849-851 |
IN |
denotes |
In |
T2599 |
852-855 |
DT |
denotes |
the |
T2601 |
856-861 |
NN |
denotes |
mouse |
T2600 |
862-867 |
NN |
denotes |
model |
T2602 |
868-870 |
IN |
denotes |
of |
T2603 |
871-873 |
NN |
denotes |
RA |
T2604 |
873-875 |
, |
denotes |
, |
T2605 |
875-880 |
JJ |
denotes |
small |
T2607 |
881-888 |
JJ |
denotes |
genetic |
T2606 |
889-902 |
NNS |
denotes |
contributions |
T2608 |
903-906 |
VBP |
denotes |
are |
T2609 |
907-911 |
RB |
denotes |
also |
T2610 |
912-917 |
RB |
denotes |
often |
T2598 |
918-926 |
VBN |
denotes |
observed |
T2611 |
926-927 |
. |
denotes |
. |
T2612 |
927-1118 |
sentence |
denotes |
For example, in a previous study, we carried out a genome screen to identify the quantitative trait loci (QTL) in collagen-induced arthritis (CIA), which is a widely used animal model of RA. |
T2613 |
928-931 |
IN |
denotes |
For |
T2615 |
932-939 |
NN |
denotes |
example |
T2616 |
939-941 |
, |
denotes |
, |
T2617 |
941-943 |
IN |
denotes |
in |
T2618 |
944-945 |
DT |
denotes |
a |
T2620 |
946-954 |
JJ |
denotes |
previous |
T2619 |
955-960 |
NN |
denotes |
study |
T2621 |
960-962 |
, |
denotes |
, |
T2622 |
962-964 |
PRP |
denotes |
we |
T2614 |
965-972 |
VBD |
denotes |
carried |
T2623 |
973-976 |
RP |
denotes |
out |
T2624 |
977-978 |
DT |
denotes |
a |
T2626 |
979-985 |
NN |
denotes |
genome |
T2625 |
986-992 |
NN |
denotes |
screen |
T2627 |
993-995 |
TO |
denotes |
to |
T2628 |
996-1004 |
VB |
denotes |
identify |
T2629 |
1005-1008 |
DT |
denotes |
the |
T2631 |
1009-1021 |
JJ |
denotes |
quantitative |
T2632 |
1022-1027 |
NN |
denotes |
trait |
T2630 |
1028-1032 |
NNS |
denotes |
loci |
T2633 |
1033-1034 |
-LRB- |
denotes |
( |
T2634 |
1034-1037 |
NN |
denotes |
QTL |
T2635 |
1037-1038 |
-RRB- |
denotes |
) |
T2636 |
1039-1041 |
IN |
denotes |
in |
T2637 |
1042-1050 |
NN |
denotes |
collagen |
T2639 |
1050-1051 |
HYPH |
denotes |
- |
T2638 |
1051-1058 |
VBN |
denotes |
induced |
T2640 |
1059-1068 |
NN |
denotes |
arthritis |
T2641 |
1069-1070 |
-LRB- |
denotes |
( |
T2642 |
1070-1073 |
NN |
denotes |
CIA |
T2643 |
1073-1074 |
-RRB- |
denotes |
) |
T2644 |
1074-1076 |
, |
denotes |
, |
T2645 |
1076-1081 |
WDT |
denotes |
which |
T2646 |
1082-1084 |
VBZ |
denotes |
is |
T2647 |
1085-1086 |
DT |
denotes |
a |
T2649 |
1087-1093 |
RB |
denotes |
widely |
T2650 |
1094-1098 |
VBN |
denotes |
used |
T2651 |
1099-1105 |
NN |
denotes |
animal |
T2648 |
1106-1111 |
NN |
denotes |
model |
T2652 |
1112-1114 |
IN |
denotes |
of |
T2653 |
1115-1117 |
NN |
denotes |
RA |
T2654 |
1117-1118 |
. |
denotes |
. |
T2655 |
1118-1296 |
sentence |
denotes |
Only one QTL, Cia2, was identified for the phenotype of CIA severity, but this QTL contributes to only 16% of the phenotype variations for CIA susceptibility in F2 progeny [10]. |
T2656 |
1119-1123 |
RB |
denotes |
Only |
T2658 |
1124-1127 |
CD |
denotes |
one |
T2657 |
1128-1131 |
NN |
denotes |
QTL |
T2660 |
1131-1133 |
, |
denotes |
, |
T2661 |
1133-1137 |
NN |
denotes |
Cia2 |
T2662 |
1137-1139 |
, |
denotes |
, |
T2663 |
1139-1142 |
VBD |
denotes |
was |
T2659 |
1143-1153 |
VBN |
denotes |
identified |
T2664 |
1154-1157 |
IN |
denotes |
for |
T2665 |
1158-1161 |
DT |
denotes |
the |
T2666 |
1162-1171 |
NN |
denotes |
phenotype |
T2667 |
1172-1174 |
IN |
denotes |
of |
T2668 |
1175-1178 |
NN |
denotes |
CIA |
T2669 |
1179-1187 |
NN |
denotes |
severity |
T2670 |
1187-1189 |
, |
denotes |
, |
T2671 |
1189-1192 |
CC |
denotes |
but |
T2672 |
1193-1197 |
DT |
denotes |
this |
T2673 |
1198-1201 |
NN |
denotes |
QTL |
T2674 |
1202-1213 |
VBZ |
denotes |
contributes |
T2675 |
1214-1216 |
IN |
denotes |
to |
T2676 |
1217-1221 |
RB |
denotes |
only |
T2677 |
1222-1224 |
CD |
denotes |
16 |
T2678 |
1224-1225 |
NN |
denotes |
% |
T2679 |
1226-1228 |
IN |
denotes |
of |
T2680 |
1229-1232 |
DT |
denotes |
the |
T2682 |
1233-1242 |
NN |
denotes |
phenotype |
T2681 |
1243-1253 |
NNS |
denotes |
variations |
T2683 |
1254-1257 |
IN |
denotes |
for |
T2684 |
1258-1261 |
NN |
denotes |
CIA |
T2685 |
1262-1276 |
NN |
denotes |
susceptibility |
T2686 |
1277-1279 |
IN |
denotes |
in |
T2687 |
1280-1282 |
NN |
denotes |
F2 |
T2688 |
1283-1290 |
NN |
denotes |
progeny |
T2689 |
1291-1292 |
-LRB- |
denotes |
[ |
T2690 |
1292-1294 |
CD |
denotes |
10 |
T2691 |
1294-1295 |
-RRB- |
denotes |
] |
T2692 |
1295-1296 |
. |
denotes |
. |
T2693 |
1296-1469 |
sentence |
denotes |
This suggests that there must be other susceptibility genes whose contributions were not big enough to reach the stringent significance threshold value of linkage analysis. |
T2694 |
1297-1301 |
DT |
denotes |
This |
T2695 |
1302-1310 |
VBZ |
denotes |
suggests |
T2696 |
1311-1315 |
IN |
denotes |
that |
T2698 |
1316-1321 |
EX |
denotes |
there |
T2699 |
1322-1326 |
MD |
denotes |
must |
T2697 |
1327-1329 |
VB |
denotes |
be |
T2700 |
1330-1335 |
JJ |
denotes |
other |
T2702 |
1336-1350 |
NN |
denotes |
susceptibility |
T2701 |
1351-1356 |
NNS |
denotes |
genes |
T2703 |
1357-1362 |
WP$ |
denotes |
whose |
T2704 |
1363-1376 |
NNS |
denotes |
contributions |
T2705 |
1377-1381 |
VBD |
denotes |
were |
T2706 |
1382-1385 |
RB |
denotes |
not |
T2707 |
1386-1389 |
JJ |
denotes |
big |
T2708 |
1390-1396 |
RB |
denotes |
enough |
T2709 |
1397-1399 |
TO |
denotes |
to |
T2710 |
1400-1405 |
VB |
denotes |
reach |
T2711 |
1406-1409 |
DT |
denotes |
the |
T2713 |
1410-1419 |
JJ |
denotes |
stringent |
T2714 |
1420-1432 |
NN |
denotes |
significance |
T2715 |
1433-1442 |
NN |
denotes |
threshold |
T2712 |
1443-1448 |
NN |
denotes |
value |
T2716 |
1449-1451 |
IN |
denotes |
of |
T2717 |
1452-1459 |
NN |
denotes |
linkage |
T2718 |
1460-1468 |
NN |
denotes |
analysis |
T2719 |
1468-1469 |
. |
denotes |
. |
T2720 |
1469-1571 |
sentence |
denotes |
One aim of using animal models for complex diseases is to detect the genetic basis of these diseases. |
T2721 |
1470-1473 |
CD |
denotes |
One |
T2722 |
1474-1477 |
NN |
denotes |
aim |
T2724 |
1478-1480 |
IN |
denotes |
of |
T2725 |
1481-1486 |
VBG |
denotes |
using |
T2726 |
1487-1493 |
NN |
denotes |
animal |
T2727 |
1494-1500 |
NNS |
denotes |
models |
T2728 |
1501-1504 |
IN |
denotes |
for |
T2729 |
1505-1512 |
JJ |
denotes |
complex |
T2730 |
1513-1521 |
NNS |
denotes |
diseases |
T2723 |
1522-1524 |
VBZ |
denotes |
is |
T2731 |
1525-1527 |
TO |
denotes |
to |
T2732 |
1528-1534 |
VB |
denotes |
detect |
T2733 |
1535-1538 |
DT |
denotes |
the |
T2735 |
1539-1546 |
JJ |
denotes |
genetic |
T2734 |
1547-1552 |
NN |
denotes |
basis |
T2736 |
1553-1555 |
IN |
denotes |
of |
T2737 |
1556-1561 |
DT |
denotes |
these |
T2738 |
1562-1570 |
NNS |
denotes |
diseases |
T2739 |
1570-1571 |
. |
denotes |
. |
T2740 |
1571-1795 |
sentence |
denotes |
With controllable environmental factors as well as the known genetic background, animal models are powerful tools to search for susceptibility genes for complex diseases, and have been intensively employed for that purpose. |
T2741 |
1572-1576 |
IN |
denotes |
With |
T2743 |
1577-1589 |
JJ |
denotes |
controllable |
T2745 |
1590-1603 |
JJ |
denotes |
environmental |
T2744 |
1604-1611 |
NNS |
denotes |
factors |
T2746 |
1612-1614 |
RB |
denotes |
as |
T2748 |
1615-1619 |
RB |
denotes |
well |
T2747 |
1620-1622 |
IN |
denotes |
as |
T2749 |
1623-1626 |
DT |
denotes |
the |
T2751 |
1627-1632 |
JJ |
denotes |
known |
T2752 |
1633-1640 |
JJ |
denotes |
genetic |
T2750 |
1641-1651 |
NN |
denotes |
background |
T2753 |
1651-1653 |
, |
denotes |
, |
T2754 |
1653-1659 |
NN |
denotes |
animal |
T2755 |
1660-1666 |
NNS |
denotes |
models |
T2742 |
1667-1670 |
VBP |
denotes |
are |
T2756 |
1671-1679 |
JJ |
denotes |
powerful |
T2757 |
1680-1685 |
NNS |
denotes |
tools |
T2758 |
1686-1688 |
TO |
denotes |
to |
T2759 |
1689-1695 |
VB |
denotes |
search |
T2760 |
1696-1699 |
IN |
denotes |
for |
T2761 |
1700-1714 |
NN |
denotes |
susceptibility |
T2762 |
1715-1720 |
NNS |
denotes |
genes |
T2763 |
1721-1724 |
IN |
denotes |
for |
T2764 |
1725-1732 |
JJ |
denotes |
complex |
T2765 |
1733-1741 |
NNS |
denotes |
diseases |
T2766 |
1741-1743 |
, |
denotes |
, |
T2767 |
1743-1746 |
CC |
denotes |
and |
T2768 |
1747-1751 |
VBP |
denotes |
have |
T2770 |
1752-1756 |
VBN |
denotes |
been |
T2771 |
1757-1768 |
RB |
denotes |
intensively |
T2769 |
1769-1777 |
VBN |
denotes |
employed |
T2772 |
1778-1781 |
IN |
denotes |
for |
T2773 |
1782-1786 |
DT |
denotes |
that |
T2774 |
1787-1794 |
NN |
denotes |
purpose |
T2775 |
1794-1795 |
. |
denotes |
. |
T2776 |
1795-1928 |
sentence |
denotes |
More than 27,000 QTL have been identified in the mouse genome since the first QTL was identified at the beginning of the 1990s [11]. |
T2777 |
1796-1800 |
JJR |
denotes |
More |
T2779 |
1801-1805 |
IN |
denotes |
than |
T2778 |
1806-1812 |
CD |
denotes |
27,000 |
T2780 |
1813-1816 |
NN |
denotes |
QTL |
T2782 |
1817-1821 |
VBP |
denotes |
have |
T2783 |
1822-1826 |
VBN |
denotes |
been |
T2781 |
1827-1837 |
VBN |
denotes |
identified |
T2784 |
1838-1840 |
IN |
denotes |
in |
T2785 |
1841-1844 |
DT |
denotes |
the |
T2787 |
1845-1850 |
NN |
denotes |
mouse |
T2786 |
1851-1857 |
NN |
denotes |
genome |
T2788 |
1858-1863 |
IN |
denotes |
since |
T2790 |
1864-1867 |
DT |
denotes |
the |
T2792 |
1868-1873 |
JJ |
denotes |
first |
T2791 |
1874-1877 |
NN |
denotes |
QTL |
T2793 |
1878-1881 |
VBD |
denotes |
was |
T2789 |
1882-1892 |
VBN |
denotes |
identified |
T2794 |
1893-1895 |
IN |
denotes |
at |
T2795 |
1896-1899 |
DT |
denotes |
the |
T2796 |
1900-1909 |
NN |
denotes |
beginning |
T2797 |
1910-1912 |
IN |
denotes |
of |
T2798 |
1913-1916 |
DT |
denotes |
the |
T2799 |
1917-1922 |
NNS |
denotes |
1990s |
T2800 |
1923-1924 |
-LRB- |
denotes |
[ |
T2801 |
1924-1926 |
CD |
denotes |
11 |
T2802 |
1926-1927 |
-RRB- |
denotes |
] |
T2803 |
1927-1928 |
. |
denotes |
. |
T2804 |
1928-2035 |
sentence |
denotes |
By 2005, approximately 20 quantitative trait genes (QTGs) in the mouse genome had been identified [12,13]. |
T2805 |
1929-1931 |
IN |
denotes |
By |
T2807 |
1932-1936 |
CD |
denotes |
2005 |
T2808 |
1936-1938 |
, |
denotes |
, |
T2809 |
1938-1951 |
RB |
denotes |
approximately |
T2810 |
1952-1954 |
CD |
denotes |
20 |
T2812 |
1955-1967 |
JJ |
denotes |
quantitative |
T2813 |
1968-1973 |
NN |
denotes |
trait |
T2811 |
1974-1979 |
NNS |
denotes |
genes |
T2814 |
1980-1981 |
-LRB- |
denotes |
( |
T2815 |
1981-1985 |
NNS |
denotes |
QTGs |
T2816 |
1985-1986 |
-RRB- |
denotes |
) |
T2817 |
1987-1989 |
IN |
denotes |
in |
T2818 |
1990-1993 |
DT |
denotes |
the |
T2820 |
1994-1999 |
NN |
denotes |
mouse |
T2819 |
2000-2006 |
NN |
denotes |
genome |
T2821 |
2007-2010 |
VBD |
denotes |
had |
T2822 |
2011-2015 |
VBN |
denotes |
been |
T2806 |
2016-2026 |
VBN |
denotes |
identified |
T2823 |
2027-2028 |
-LRB- |
denotes |
[ |
T2825 |
2028-2030 |
CD |
denotes |
12 |
T2826 |
2030-2031 |
, |
denotes |
, |
T2824 |
2031-2033 |
CD |
denotes |
13 |
T2827 |
2033-2034 |
-RRB- |
denotes |
] |
T2828 |
2034-2035 |
. |
denotes |
. |
T2829 |
2035-2216 |
sentence |
denotes |
Interestingly, most QTGs identified in animal models have the causal polymorphisms in the protein-coding region [14], which provoke protein structure changes or protein deficiency. |
T2830 |
2036-2049 |
RB |
denotes |
Interestingly |
T2832 |
2049-2051 |
, |
denotes |
, |
T2833 |
2051-2055 |
JJS |
denotes |
most |
T2834 |
2056-2060 |
NNS |
denotes |
QTGs |
T2835 |
2061-2071 |
VBN |
denotes |
identified |
T2836 |
2072-2074 |
IN |
denotes |
in |
T2837 |
2075-2081 |
NN |
denotes |
animal |
T2838 |
2082-2088 |
NNS |
denotes |
models |
T2831 |
2089-2093 |
VBP |
denotes |
have |
T2839 |
2094-2097 |
DT |
denotes |
the |
T2841 |
2098-2104 |
JJ |
denotes |
causal |
T2840 |
2105-2118 |
NNS |
denotes |
polymorphisms |
T2842 |
2119-2121 |
IN |
denotes |
in |
T2843 |
2122-2125 |
DT |
denotes |
the |
T2845 |
2126-2133 |
NN |
denotes |
protein |
T2847 |
2133-2134 |
HYPH |
denotes |
- |
T2846 |
2134-2140 |
VBG |
denotes |
coding |
T2844 |
2141-2147 |
NN |
denotes |
region |
T2848 |
2148-2149 |
-LRB- |
denotes |
[ |
T2849 |
2149-2151 |
CD |
denotes |
14 |
T2850 |
2151-2152 |
-RRB- |
denotes |
] |
T2851 |
2152-2154 |
, |
denotes |
, |
T2852 |
2154-2159 |
WDT |
denotes |
which |
T2853 |
2160-2167 |
VBP |
denotes |
provoke |
T2854 |
2168-2175 |
NN |
denotes |
protein |
T2856 |
2176-2185 |
NN |
denotes |
structure |
T2855 |
2186-2193 |
NNS |
denotes |
changes |
T2857 |
2194-2196 |
CC |
denotes |
or |
T2858 |
2197-2204 |
NN |
denotes |
protein |
T2859 |
2205-2215 |
NN |
denotes |
deficiency |
T2860 |
2215-2216 |
. |
denotes |
. |
T2861 |
2216-2491 |
sentence |
denotes |
This suggests, on the one hand, that small-effect QTL are difficult to identify with traditional strategies and, on the other hand, that the polymorphisms regulating gene expression might only slightly affect the quantitative traits, and thus are more difficult to identify. |
T2862 |
2217-2221 |
DT |
denotes |
This |
T2863 |
2222-2230 |
VBZ |
denotes |
suggests |
T2864 |
2230-2232 |
, |
denotes |
, |
T2865 |
2232-2234 |
IN |
denotes |
on |
T2867 |
2235-2238 |
DT |
denotes |
the |
T2869 |
2239-2242 |
CD |
denotes |
one |
T2868 |
2243-2247 |
NN |
denotes |
hand |
T2870 |
2247-2249 |
, |
denotes |
, |
T2871 |
2249-2253 |
IN |
denotes |
that |
T2872 |
2254-2259 |
JJ |
denotes |
small |
T2874 |
2259-2260 |
HYPH |
denotes |
- |
T2873 |
2260-2266 |
NN |
denotes |
effect |
T2875 |
2267-2270 |
NN |
denotes |
QTL |
T2866 |
2271-2274 |
VBP |
denotes |
are |
T2876 |
2275-2284 |
JJ |
denotes |
difficult |
T2877 |
2285-2287 |
TO |
denotes |
to |
T2878 |
2288-2296 |
VB |
denotes |
identify |
T2879 |
2297-2301 |
IN |
denotes |
with |
T2880 |
2302-2313 |
JJ |
denotes |
traditional |
T2881 |
2314-2324 |
NNS |
denotes |
strategies |
T2882 |
2325-2328 |
CC |
denotes |
and |
T2883 |
2328-2330 |
, |
denotes |
, |
T2884 |
2330-2332 |
IN |
denotes |
on |
T2886 |
2333-2336 |
DT |
denotes |
the |
T2888 |
2337-2342 |
JJ |
denotes |
other |
T2887 |
2343-2347 |
NN |
denotes |
hand |
T2889 |
2347-2349 |
, |
denotes |
, |
T2890 |
2349-2353 |
IN |
denotes |
that |
T2891 |
2354-2357 |
DT |
denotes |
the |
T2892 |
2358-2371 |
NNS |
denotes |
polymorphisms |
T2893 |
2372-2382 |
VBG |
denotes |
regulating |
T2894 |
2383-2387 |
NN |
denotes |
gene |
T2895 |
2388-2398 |
NN |
denotes |
expression |
T2896 |
2399-2404 |
MD |
denotes |
might |
T2897 |
2405-2409 |
RB |
denotes |
only |
T2898 |
2410-2418 |
RB |
denotes |
slightly |
T2885 |
2419-2425 |
VB |
denotes |
affect |
T2899 |
2426-2429 |
DT |
denotes |
the |
T2901 |
2430-2442 |
JJ |
denotes |
quantitative |
T2900 |
2443-2449 |
NNS |
denotes |
traits |
T2902 |
2449-2451 |
, |
denotes |
, |
T2903 |
2451-2454 |
CC |
denotes |
and |
T2904 |
2455-2459 |
RB |
denotes |
thus |
T2905 |
2460-2463 |
VBP |
denotes |
are |
T2906 |
2464-2468 |
RBR |
denotes |
more |
T2907 |
2469-2478 |
JJ |
denotes |
difficult |
T2908 |
2479-2481 |
TO |
denotes |
to |
T2909 |
2482-2490 |
VB |
denotes |
identify |
T2910 |
2490-2491 |
. |
denotes |
. |
T2911 |
2491-2591 |
sentence |
denotes |
Microarray-based global gene expression is a powerful technique for investigating complex diseases. |
T2912 |
2492-2502 |
NN |
denotes |
Microarray |
T2914 |
2502-2503 |
HYPH |
denotes |
- |
T2913 |
2503-2508 |
VBN |
denotes |
based |
T2916 |
2509-2515 |
JJ |
denotes |
global |
T2917 |
2516-2520 |
NN |
denotes |
gene |
T2915 |
2521-2531 |
NN |
denotes |
expression |
T2918 |
2532-2534 |
VBZ |
denotes |
is |
T2919 |
2535-2536 |
DT |
denotes |
a |
T2921 |
2537-2545 |
JJ |
denotes |
powerful |
T2920 |
2546-2555 |
NN |
denotes |
technique |
T2922 |
2556-2559 |
IN |
denotes |
for |
T2923 |
2560-2573 |
VBG |
denotes |
investigating |
T2924 |
2574-2581 |
JJ |
denotes |
complex |
T2925 |
2582-2590 |
NNS |
denotes |
diseases |
T2926 |
2590-2591 |
. |
denotes |
. |
T2927 |
2591-2692 |
sentence |
denotes |
During disease development, genes involved in the disease are likely to be differentially regulated. |
T2928 |
2592-2598 |
IN |
denotes |
During |
T2930 |
2599-2606 |
NN |
denotes |
disease |
T2931 |
2607-2618 |
NN |
denotes |
development |
T2932 |
2618-2620 |
, |
denotes |
, |
T2933 |
2620-2625 |
NNS |
denotes |
genes |
T2934 |
2626-2634 |
VBN |
denotes |
involved |
T2935 |
2635-2637 |
IN |
denotes |
in |
T2936 |
2638-2641 |
DT |
denotes |
the |
T2937 |
2642-2649 |
NN |
denotes |
disease |
T2929 |
2650-2653 |
VBP |
denotes |
are |
T2938 |
2654-2660 |
JJ |
denotes |
likely |
T2939 |
2661-2663 |
TO |
denotes |
to |
T2941 |
2664-2666 |
VB |
denotes |
be |
T2942 |
2667-2681 |
RB |
denotes |
differentially |
T2940 |
2682-2691 |
VBN |
denotes |
regulated |
T2943 |
2691-2692 |
. |
denotes |
. |
T2944 |
2692-2855 |
sentence |
denotes |
Therefore, signature genes of the diseases could be identified by detecting the expression patterns of the disease-related cells/tissues and their ideal controls. |
T2945 |
2693-2702 |
RB |
denotes |
Therefore |
T2947 |
2702-2704 |
, |
denotes |
, |
T2948 |
2704-2713 |
NN |
denotes |
signature |
T2949 |
2714-2719 |
NNS |
denotes |
genes |
T2950 |
2720-2722 |
IN |
denotes |
of |
T2951 |
2723-2726 |
DT |
denotes |
the |
T2952 |
2727-2735 |
NNS |
denotes |
diseases |
T2953 |
2736-2741 |
MD |
denotes |
could |
T2954 |
2742-2744 |
VB |
denotes |
be |
T2946 |
2745-2755 |
VBN |
denotes |
identified |
T2955 |
2756-2758 |
IN |
denotes |
by |
T2956 |
2759-2768 |
VBG |
denotes |
detecting |
T2957 |
2769-2772 |
DT |
denotes |
the |
T2959 |
2773-2783 |
NN |
denotes |
expression |
T2958 |
2784-2792 |
NNS |
denotes |
patterns |
T2960 |
2793-2795 |
IN |
denotes |
of |
T2961 |
2796-2799 |
DT |
denotes |
the |
T2963 |
2800-2807 |
NN |
denotes |
disease |
T2965 |
2807-2808 |
HYPH |
denotes |
- |
T2964 |
2808-2815 |
VBN |
denotes |
related |
T2966 |
2816-2821 |
NNS |
denotes |
cells |
T2967 |
2821-2822 |
HYPH |
denotes |
/ |
T2962 |
2822-2829 |
NNS |
denotes |
tissues |
T2968 |
2830-2833 |
CC |
denotes |
and |
T2969 |
2834-2839 |
PRP$ |
denotes |
their |
T2971 |
2840-2845 |
JJ |
denotes |
ideal |
T2970 |
2846-2854 |
NNS |
denotes |
controls |
T2972 |
2854-2855 |
. |
denotes |
. |
T2973 |
2855-2959 |
sentence |
denotes |
In the past decade, many studies applied this technique to study both RA and its animal models [15-22]. |
T2974 |
2856-2858 |
IN |
denotes |
In |
T2976 |
2859-2862 |
DT |
denotes |
the |
T2978 |
2863-2867 |
JJ |
denotes |
past |
T2977 |
2868-2874 |
NN |
denotes |
decade |
T2979 |
2874-2876 |
, |
denotes |
, |
T2980 |
2876-2880 |
JJ |
denotes |
many |
T2981 |
2881-2888 |
NNS |
denotes |
studies |
T2975 |
2889-2896 |
VBD |
denotes |
applied |
T2982 |
2897-2901 |
DT |
denotes |
this |
T2983 |
2902-2911 |
NN |
denotes |
technique |
T2984 |
2912-2914 |
TO |
denotes |
to |
T2985 |
2915-2920 |
VB |
denotes |
study |
T2986 |
2921-2925 |
CC |
denotes |
both |
T2987 |
2926-2928 |
NN |
denotes |
RA |
T2988 |
2929-2932 |
CC |
denotes |
and |
T2989 |
2933-2936 |
PRP$ |
denotes |
its |
T2991 |
2937-2943 |
NN |
denotes |
animal |
T2990 |
2944-2950 |
NNS |
denotes |
models |
T2992 |
2951-2952 |
-LRB- |
denotes |
[ |
T2993 |
2952-2954 |
CD |
denotes |
15 |
T2994 |
2954-2955 |
SYM |
denotes |
- |
T2995 |
2955-2957 |
CD |
denotes |
22 |
T2996 |
2957-2958 |
-RRB- |
denotes |
] |
T2997 |
2958-2959 |
. |
denotes |
. |
T2998 |
2959-3088 |
sentence |
denotes |
Indeed, genes involved in arthritis show distinct expression patterns in certain tissues and pathological stages of the disease. |
T2999 |
2960-2966 |
RB |
denotes |
Indeed |
T3001 |
2966-2968 |
, |
denotes |
, |
T3002 |
2968-2973 |
NNS |
denotes |
genes |
T3003 |
2974-2982 |
VBN |
denotes |
involved |
T3004 |
2983-2985 |
IN |
denotes |
in |
T3005 |
2986-2995 |
NN |
denotes |
arthritis |
T3000 |
2996-3000 |
VBP |
denotes |
show |
T3006 |
3001-3009 |
JJ |
denotes |
distinct |
T3008 |
3010-3020 |
NN |
denotes |
expression |
T3007 |
3021-3029 |
NNS |
denotes |
patterns |
T3009 |
3030-3032 |
IN |
denotes |
in |
T3010 |
3033-3040 |
JJ |
denotes |
certain |
T3011 |
3041-3048 |
NNS |
denotes |
tissues |
T3012 |
3049-3052 |
CC |
denotes |
and |
T3013 |
3053-3065 |
JJ |
denotes |
pathological |
T3014 |
3066-3072 |
NNS |
denotes |
stages |
T3015 |
3073-3075 |
IN |
denotes |
of |
T3016 |
3076-3079 |
DT |
denotes |
the |
T3017 |
3080-3087 |
NN |
denotes |
disease |
T3018 |
3087-3088 |
. |
denotes |
. |
T3019 |
3088-3205 |
sentence |
denotes |
Genes involved in immunoinflammatory responses were differentially expressed in the blood cells in RA patients [18]. |
T3020 |
3089-3094 |
NNS |
denotes |
Genes |
T3022 |
3095-3103 |
VBN |
denotes |
involved |
T3023 |
3104-3106 |
IN |
denotes |
in |
T3024 |
3107-3125 |
JJ |
denotes |
immunoinflammatory |
T3025 |
3126-3135 |
NNS |
denotes |
responses |
T3026 |
3136-3140 |
VBD |
denotes |
were |
T3027 |
3141-3155 |
RB |
denotes |
differentially |
T3021 |
3156-3165 |
VBN |
denotes |
expressed |
T3028 |
3166-3168 |
IN |
denotes |
in |
T3029 |
3169-3172 |
DT |
denotes |
the |
T3031 |
3173-3178 |
NN |
denotes |
blood |
T3030 |
3179-3184 |
NNS |
denotes |
cells |
T3032 |
3185-3187 |
IN |
denotes |
in |
T3033 |
3188-3190 |
NN |
denotes |
RA |
T3034 |
3191-3199 |
NNS |
denotes |
patients |
T3035 |
3200-3201 |
-LRB- |
denotes |
[ |
T3036 |
3201-3203 |
CD |
denotes |
18 |
T3037 |
3203-3204 |
-RRB- |
denotes |
] |
T3038 |
3204-3205 |
. |
denotes |
. |
T3039 |
3205-3488 |
sentence |
denotes |
Chemokines and adhesion molecules were upregulated in the joint at the initiation phase of arthritis in animal models [21,22], while genes involved in cartilage destruction and bone erosion were differentially expressed at the late phase of arthritis in animal models of RA [15,16]. |
T3040 |
3206-3216 |
NNS |
denotes |
Chemokines |
T3042 |
3217-3220 |
CC |
denotes |
and |
T3043 |
3221-3229 |
NN |
denotes |
adhesion |
T3044 |
3230-3239 |
NNS |
denotes |
molecules |
T3045 |
3240-3244 |
VBD |
denotes |
were |
T3041 |
3245-3256 |
VBN |
denotes |
upregulated |
T3046 |
3257-3259 |
IN |
denotes |
in |
T3047 |
3260-3263 |
DT |
denotes |
the |
T3048 |
3264-3269 |
NN |
denotes |
joint |
T3049 |
3270-3272 |
IN |
denotes |
at |
T3050 |
3273-3276 |
DT |
denotes |
the |
T3052 |
3277-3287 |
NN |
denotes |
initiation |
T3051 |
3288-3293 |
NN |
denotes |
phase |
T3053 |
3294-3296 |
IN |
denotes |
of |
T3054 |
3297-3306 |
NN |
denotes |
arthritis |
T3055 |
3307-3309 |
IN |
denotes |
in |
T3056 |
3310-3316 |
NN |
denotes |
animal |
T3057 |
3317-3323 |
NNS |
denotes |
models |
T3058 |
3324-3325 |
-LRB- |
denotes |
[ |
T3060 |
3325-3327 |
CD |
denotes |
21 |
T3061 |
3327-3328 |
, |
denotes |
, |
T3059 |
3328-3330 |
CD |
denotes |
22 |
T3062 |
3330-3331 |
-RRB- |
denotes |
] |
T3063 |
3331-3333 |
, |
denotes |
, |
T3064 |
3333-3338 |
IN |
denotes |
while |
T3066 |
3339-3344 |
NNS |
denotes |
genes |
T3067 |
3345-3353 |
VBN |
denotes |
involved |
T3068 |
3354-3356 |
IN |
denotes |
in |
T3069 |
3357-3366 |
NN |
denotes |
cartilage |
T3070 |
3367-3378 |
NN |
denotes |
destruction |
T3071 |
3379-3382 |
CC |
denotes |
and |
T3072 |
3383-3387 |
NN |
denotes |
bone |
T3073 |
3388-3395 |
NN |
denotes |
erosion |
T3074 |
3396-3400 |
VBD |
denotes |
were |
T3075 |
3401-3415 |
RB |
denotes |
differentially |
T3065 |
3416-3425 |
VBN |
denotes |
expressed |
T3076 |
3426-3428 |
IN |
denotes |
at |
T3077 |
3429-3432 |
DT |
denotes |
the |
T3079 |
3433-3437 |
JJ |
denotes |
late |
T3078 |
3438-3443 |
NN |
denotes |
phase |
T3080 |
3444-3446 |
IN |
denotes |
of |
T3081 |
3447-3456 |
NN |
denotes |
arthritis |
T3082 |
3457-3459 |
IN |
denotes |
in |
T3083 |
3460-3466 |
NN |
denotes |
animal |
T3084 |
3467-3473 |
NNS |
denotes |
models |
T3085 |
3474-3476 |
IN |
denotes |
of |
T3086 |
3477-3479 |
NN |
denotes |
RA |
T3087 |
3480-3481 |
-LRB- |
denotes |
[ |
T3089 |
3481-3483 |
CD |
denotes |
15 |
T3090 |
3483-3484 |
, |
denotes |
, |
T3088 |
3484-3486 |
CD |
denotes |
16 |
T3091 |
3486-3487 |
-RRB- |
denotes |
] |
T3092 |
3487-3488 |
. |
denotes |
. |
T3093 |
3488-3759 |
sentence |
denotes |
Besides detecting genes involved in complex diseases, microarrays could also be used to detect the genetic polymorphisms regulating gene expression because differential expressions between two strains might be the result of a polymorphism located in regulatory elements. |
T3094 |
3489-3496 |
IN |
denotes |
Besides |
T3095 |
3497-3506 |
VBG |
denotes |
detecting |
T3097 |
3507-3512 |
NNS |
denotes |
genes |
T3098 |
3513-3521 |
VBN |
denotes |
involved |
T3099 |
3522-3524 |
IN |
denotes |
in |
T3100 |
3525-3532 |
JJ |
denotes |
complex |
T3101 |
3533-3541 |
NNS |
denotes |
diseases |
T3102 |
3541-3543 |
, |
denotes |
, |
T3103 |
3543-3554 |
NNS |
denotes |
microarrays |
T3104 |
3555-3560 |
MD |
denotes |
could |
T3105 |
3561-3565 |
RB |
denotes |
also |
T3106 |
3566-3568 |
VB |
denotes |
be |
T3096 |
3569-3573 |
VBN |
denotes |
used |
T3107 |
3574-3576 |
TO |
denotes |
to |
T3108 |
3577-3583 |
VB |
denotes |
detect |
T3109 |
3584-3587 |
DT |
denotes |
the |
T3111 |
3588-3595 |
JJ |
denotes |
genetic |
T3110 |
3596-3609 |
NNS |
denotes |
polymorphisms |
T3112 |
3610-3620 |
VBG |
denotes |
regulating |
T3113 |
3621-3625 |
NN |
denotes |
gene |
T3114 |
3626-3636 |
NN |
denotes |
expression |
T3115 |
3637-3644 |
IN |
denotes |
because |
T3117 |
3645-3657 |
JJ |
denotes |
differential |
T3118 |
3658-3669 |
NNS |
denotes |
expressions |
T3119 |
3670-3677 |
IN |
denotes |
between |
T3120 |
3678-3681 |
CD |
denotes |
two |
T3121 |
3682-3689 |
NNS |
denotes |
strains |
T3122 |
3690-3695 |
MD |
denotes |
might |
T3116 |
3696-3698 |
VB |
denotes |
be |
T3123 |
3699-3702 |
DT |
denotes |
the |
T3124 |
3703-3709 |
NN |
denotes |
result |
T3125 |
3710-3712 |
IN |
denotes |
of |
T3126 |
3713-3714 |
DT |
denotes |
a |
T3127 |
3715-3727 |
NN |
denotes |
polymorphism |
T3128 |
3728-3735 |
VBN |
denotes |
located |
T3129 |
3736-3738 |
IN |
denotes |
in |
T3130 |
3739-3749 |
JJ |
denotes |
regulatory |
T3131 |
3750-3758 |
NNS |
denotes |
elements |
T3132 |
3758-3759 |
. |
denotes |
. |
T3133 |
3759-3964 |
sentence |
denotes |
To identify the small-effect QTL of CIA as well as the potential candidate genes inside them, we investigated CIA genetically susceptible and resistant strains at both the genome and transcriptome levels. |
T3134 |
3760-3762 |
TO |
denotes |
To |
T3135 |
3763-3771 |
VB |
denotes |
identify |
T3137 |
3772-3775 |
DT |
denotes |
the |
T3139 |
3776-3781 |
JJ |
denotes |
small |
T3141 |
3781-3782 |
HYPH |
denotes |
- |
T3140 |
3782-3788 |
NN |
denotes |
effect |
T3138 |
3789-3792 |
NN |
denotes |
QTL |
T3142 |
3793-3795 |
IN |
denotes |
of |
T3143 |
3796-3799 |
NN |
denotes |
CIA |
T3144 |
3800-3802 |
RB |
denotes |
as |
T3146 |
3803-3807 |
RB |
denotes |
well |
T3145 |
3808-3810 |
IN |
denotes |
as |
T3147 |
3811-3814 |
DT |
denotes |
the |
T3149 |
3815-3824 |
JJ |
denotes |
potential |
T3150 |
3825-3834 |
NN |
denotes |
candidate |
T3148 |
3835-3840 |
NNS |
denotes |
genes |
T3151 |
3841-3847 |
IN |
denotes |
inside |
T3152 |
3848-3852 |
PRP |
denotes |
them |
T3153 |
3852-3854 |
, |
denotes |
, |
T3154 |
3854-3856 |
PRP |
denotes |
we |
T3136 |
3857-3869 |
VBD |
denotes |
investigated |
T3155 |
3870-3873 |
NN |
denotes |
CIA |
T3157 |
3874-3885 |
RB |
denotes |
genetically |
T3156 |
3886-3897 |
JJ |
denotes |
susceptible |
T3159 |
3898-3901 |
CC |
denotes |
and |
T3160 |
3902-3911 |
JJ |
denotes |
resistant |
T3158 |
3912-3919 |
NNS |
denotes |
strains |
T3161 |
3920-3922 |
IN |
denotes |
at |
T3162 |
3923-3927 |
CC |
denotes |
both |
T3164 |
3928-3931 |
DT |
denotes |
the |
T3163 |
3932-3938 |
NN |
denotes |
genome |
T3166 |
3939-3942 |
CC |
denotes |
and |
T3167 |
3943-3956 |
NN |
denotes |
transcriptome |
T3165 |
3957-3963 |
NNS |
denotes |
levels |
T3168 |
3963-3964 |
. |
denotes |
. |
T3169 |
3964-4151 |
sentence |
denotes |
At the genome level, F2 progeny of the CIA susceptible (DBA/1) and resistant (FVB/N) strains were generated and a genome-wide linkage analysis was performed to identify small-effect QTL. |
T3170 |
3965-3967 |
IN |
denotes |
At |
T3172 |
3968-3971 |
DT |
denotes |
the |
T3174 |
3972-3978 |
NN |
denotes |
genome |
T3173 |
3979-3984 |
NN |
denotes |
level |
T3175 |
3984-3986 |
, |
denotes |
, |
T3176 |
3986-3988 |
NN |
denotes |
F2 |
T3177 |
3989-3996 |
NN |
denotes |
progeny |
T3178 |
3997-3999 |
IN |
denotes |
of |
T3179 |
4000-4003 |
DT |
denotes |
the |
T3181 |
4004-4007 |
NN |
denotes |
CIA |
T3182 |
4008-4019 |
JJ |
denotes |
susceptible |
T3183 |
4020-4021 |
-LRB- |
denotes |
( |
T3184 |
4021-4024 |
NN |
denotes |
DBA |
T3185 |
4024-4025 |
HYPH |
denotes |
/ |
T3186 |
4025-4026 |
CD |
denotes |
1 |
T3187 |
4026-4027 |
-RRB- |
denotes |
) |
T3188 |
4028-4031 |
CC |
denotes |
and |
T3189 |
4032-4041 |
JJ |
denotes |
resistant |
T3190 |
4042-4043 |
-LRB- |
denotes |
( |
T3192 |
4043-4046 |
NN |
denotes |
FVB |
T3193 |
4046-4047 |
HYPH |
denotes |
/ |
T3191 |
4047-4048 |
NN |
denotes |
N |
T3194 |
4048-4049 |
-RRB- |
denotes |
) |
T3180 |
4050-4057 |
NNS |
denotes |
strains |
T3195 |
4058-4062 |
VBD |
denotes |
were |
T3171 |
4063-4072 |
VBN |
denotes |
generated |
T3196 |
4073-4076 |
CC |
denotes |
and |
T3197 |
4077-4078 |
DT |
denotes |
a |
T3199 |
4079-4085 |
NN |
denotes |
genome |
T3201 |
4085-4086 |
HYPH |
denotes |
- |
T3200 |
4086-4090 |
JJ |
denotes |
wide |
T3202 |
4091-4098 |
NN |
denotes |
linkage |
T3198 |
4099-4107 |
NN |
denotes |
analysis |
T3204 |
4108-4111 |
VBD |
denotes |
was |
T3203 |
4112-4121 |
VBN |
denotes |
performed |
T3205 |
4122-4124 |
TO |
denotes |
to |
T3206 |
4125-4133 |
VB |
denotes |
identify |
T3207 |
4134-4139 |
JJ |
denotes |
small |
T3209 |
4139-4140 |
HYPH |
denotes |
- |
T3208 |
4140-4146 |
NN |
denotes |
effect |
T3210 |
4147-4150 |
NN |
denotes |
QTL |
T3211 |
4150-4151 |
. |
denotes |
. |
T3212 |
4151-4289 |
sentence |
denotes |
At the transcriptome level, we detected the gene expression patterns of both the DBA/1 and FVB/N strains at four different phases of CIA. |
T3213 |
4152-4154 |
IN |
denotes |
At |
T3215 |
4155-4158 |
DT |
denotes |
the |
T3217 |
4159-4172 |
NN |
denotes |
transcriptome |
T3216 |
4173-4178 |
NN |
denotes |
level |
T3218 |
4178-4180 |
, |
denotes |
, |
T3219 |
4180-4182 |
PRP |
denotes |
we |
T3214 |
4183-4191 |
VBD |
denotes |
detected |
T3220 |
4192-4195 |
DT |
denotes |
the |
T3222 |
4196-4200 |
NN |
denotes |
gene |
T3223 |
4201-4211 |
NN |
denotes |
expression |
T3221 |
4212-4220 |
NNS |
denotes |
patterns |
T3224 |
4221-4223 |
IN |
denotes |
of |
T3225 |
4224-4228 |
CC |
denotes |
both |
T3227 |
4229-4232 |
DT |
denotes |
the |
T3228 |
4233-4236 |
NN |
denotes |
DBA |
T3229 |
4236-4237 |
HYPH |
denotes |
/ |
T3230 |
4237-4238 |
CD |
denotes |
1 |
T3231 |
4239-4242 |
CC |
denotes |
and |
T3232 |
4243-4246 |
NN |
denotes |
FVB |
T3234 |
4246-4247 |
HYPH |
denotes |
/ |
T3233 |
4247-4248 |
NN |
denotes |
N |
T3226 |
4249-4256 |
NNS |
denotes |
strains |
T3235 |
4257-4259 |
IN |
denotes |
at |
T3236 |
4260-4264 |
CD |
denotes |
four |
T3238 |
4265-4274 |
JJ |
denotes |
different |
T3237 |
4275-4281 |
NNS |
denotes |
phases |
T3239 |
4282-4284 |
IN |
denotes |
of |
T3240 |
4285-4288 |
NN |
denotes |
CIA |
T3241 |
4288-4289 |
. |
denotes |
. |
T3242 |
4289-4580 |
sentence |
denotes |
The potential candidate genes were identified based on three criteria: they are located within the genomic region linked to CIA; they are disease-specific differentially expressed during CIA; and they are strain-specific differentially expressed between the two parental strains during CIA. |
T3243 |
4290-4293 |
DT |
denotes |
The |
T3245 |
4294-4303 |
JJ |
denotes |
potential |
T3246 |
4304-4313 |
NN |
denotes |
candidate |
T3244 |
4314-4319 |
NNS |
denotes |
genes |
T3248 |
4320-4324 |
VBD |
denotes |
were |
T3247 |
4325-4335 |
VBN |
denotes |
identified |
T3250 |
4336-4341 |
VBN |
denotes |
based |
T3251 |
4342-4344 |
IN |
denotes |
on |
T3252 |
4345-4350 |
CD |
denotes |
three |
T3253 |
4351-4359 |
NNS |
denotes |
criteria |
T3254 |
4359-4361 |
: |
denotes |
: |
T3255 |
4361-4365 |
PRP |
denotes |
they |
T3256 |
4366-4369 |
VBP |
denotes |
are |
T3249 |
4370-4377 |
VBN |
denotes |
located |
T3257 |
4378-4384 |
IN |
denotes |
within |
T3258 |
4385-4388 |
DT |
denotes |
the |
T3260 |
4389-4396 |
JJ |
denotes |
genomic |
T3259 |
4397-4403 |
NN |
denotes |
region |
T3261 |
4404-4410 |
VBN |
denotes |
linked |
T3262 |
4411-4413 |
IN |
denotes |
to |
T3263 |
4414-4417 |
NN |
denotes |
CIA |
T3264 |
4417-4418 |
: |
denotes |
; |
T3265 |
4419-4423 |
PRP |
denotes |
they |
T3267 |
4424-4427 |
VBP |
denotes |
are |
T3268 |
4428-4435 |
NN |
denotes |
disease |
T3270 |
4435-4436 |
HYPH |
denotes |
- |
T3269 |
4436-4444 |
RB |
denotes |
specific |
T3271 |
4445-4459 |
RB |
denotes |
differentially |
T3266 |
4460-4469 |
VBN |
denotes |
expressed |
T3272 |
4470-4476 |
IN |
denotes |
during |
T3273 |
4477-4480 |
NN |
denotes |
CIA |
T3274 |
4480-4481 |
: |
denotes |
; |
T3275 |
4482-4485 |
CC |
denotes |
and |
T3276 |
4486-4490 |
PRP |
denotes |
they |
T3278 |
4491-4494 |
VBP |
denotes |
are |
T3279 |
4495-4501 |
NN |
denotes |
strain |
T3281 |
4501-4502 |
HYPH |
denotes |
- |
T3280 |
4502-4510 |
RB |
denotes |
specific |
T3282 |
4511-4525 |
RB |
denotes |
differentially |
T3277 |
4526-4535 |
VBN |
denotes |
expressed |
T3283 |
4536-4543 |
IN |
denotes |
between |
T3284 |
4544-4547 |
DT |
denotes |
the |
T3286 |
4548-4551 |
CD |
denotes |
two |
T3287 |
4552-4560 |
JJ |
denotes |
parental |
T3285 |
4561-4568 |
NNS |
denotes |
strains |
T3288 |
4569-4575 |
IN |
denotes |
during |
T3289 |
4576-4579 |
NN |
denotes |
CIA |
T3290 |
4579-4580 |
. |
denotes |
. |
R1000 |
T3269 |
T3266 |
advmod |
specific,expressed |
R1001 |
T3270 |
T3269 |
punct |
-,specific |
R1002 |
T3271 |
T3266 |
advmod |
differentially,expressed |
R1003 |
T3272 |
T3266 |
prep |
during,expressed |
R1004 |
T3273 |
T3272 |
pobj |
CIA,during |
R1005 |
T3274 |
T3266 |
punct |
;,expressed |
R1006 |
T3275 |
T3266 |
cc |
and,expressed |
R1007 |
T3276 |
T3277 |
nsubjpass |
they,expressed |
R1008 |
T3277 |
T3266 |
conj |
expressed,expressed |
R1009 |
T3278 |
T3277 |
auxpass |
are,expressed |
R1010 |
T3279 |
T3280 |
npadvmod |
strain,specific |
R1011 |
T3280 |
T3277 |
advmod |
specific,expressed |
R1012 |
T3281 |
T3280 |
punct |
-,specific |
R1013 |
T3282 |
T3277 |
advmod |
differentially,expressed |
R1014 |
T3283 |
T3277 |
prep |
between,expressed |
R1015 |
T3284 |
T3285 |
det |
the,strains |
R1016 |
T3285 |
T3283 |
pobj |
strains,between |
R1017 |
T3286 |
T3285 |
nummod |
two,strains |
R1018 |
T3287 |
T3285 |
amod |
parental,strains |
R1019 |
T3288 |
T3277 |
prep |
during,expressed |
R1020 |
T3289 |
T3288 |
pobj |
CIA,during |
R1021 |
T3290 |
T3249 |
punct |
.,located |
R210 |
T2422 |
T2423 |
nsubjpass |
Susceptibility,controlled |
R211 |
T2424 |
T2422 |
prep |
to,Susceptibility |
R212 |
T2425 |
T2426 |
advmod |
most,diseases |
R213 |
T2426 |
T2424 |
pobj |
diseases,to |
R214 |
T2427 |
T2426 |
amod |
complex,diseases |
R215 |
T2428 |
T2423 |
auxpass |
is,controlled |
R216 |
T2429 |
T2423 |
agent |
by,controlled |
R217 |
T2430 |
T2431 |
amod |
many,genes |
R218 |
T2431 |
T2429 |
pobj |
genes,by |
R219 |
T2432 |
T2431 |
punct |
", ",genes |
R220 |
T2433 |
T2434 |
advmod |
each,having |
R221 |
T2434 |
T2431 |
acl |
having,genes |
R222 |
T2435 |
T2436 |
det |
a,effect |
R223 |
T2436 |
T2434 |
dobj |
effect,having |
R224 |
T2437 |
T2436 |
amod |
small,effect |
R225 |
T2438 |
T2436 |
prep |
on,effect |
R226 |
T2439 |
T2440 |
det |
the,disease |
R227 |
T2440 |
T2438 |
pobj |
disease,on |
R228 |
T2441 |
T2423 |
punct |
.,controlled |
R229 |
T2443 |
T2444 |
nummod |
One,example |
R230 |
T2444 |
T2445 |
nsubj |
example,is |
R231 |
T2446 |
T2447 |
amod |
rheumatoid,arthritis |
R232 |
T2447 |
T2445 |
attr |
arthritis,is |
R233 |
T2448 |
T2447 |
punct |
(,arthritis |
R234 |
T2449 |
T2447 |
appos |
RA,arthritis |
R235 |
T2450 |
T2447 |
punct |
),arthritis |
R236 |
T2451 |
T2447 |
punct |
", ",arthritis |
R237 |
T2452 |
T2453 |
det |
a,disease |
R238 |
T2453 |
T2447 |
appos |
disease,arthritis |
R239 |
T2454 |
T2453 |
amod |
common,disease |
R240 |
T2455 |
T2453 |
nmod |
complex,disease |
R241 |
T2456 |
T2453 |
amod |
multifactorial,disease |
R242 |
T2457 |
T2453 |
amod |
autoimmune,disease |
R243 |
T2458 |
T2445 |
punct |
.,is |
R244 |
T2460 |
T2461 |
amod |
Several,studies |
R245 |
T2461 |
T2462 |
nsubjpass |
studies,carried |
R246 |
T2463 |
T2462 |
aux |
have,carried |
R247 |
T2464 |
T2462 |
auxpass |
been,carried |
R248 |
T2465 |
T2462 |
prt |
out,carried |
R249 |
T2466 |
T2467 |
aux |
to,detect |
R250 |
T2467 |
T2462 |
advcl |
detect,carried |
R251 |
T2468 |
T2469 |
det |
the,basis |
R252 |
T2469 |
T2467 |
dobj |
basis,detect |
R253 |
T2470 |
T2469 |
amod |
genetic,basis |
R254 |
T2471 |
T2469 |
prep |
of,basis |
R255 |
T2472 |
T2471 |
pobj |
RA,of |
R256 |
T2473 |
T2462 |
punct |
", ",carried |
R257 |
T2474 |
T2462 |
cc |
and,carried |
R258 |
T2475 |
T2476 |
amod |
more,30 |
R259 |
T2476 |
T2478 |
nummod |
30,regions |
R260 |
T2477 |
T2476 |
quantmod |
than,30 |
R261 |
T2478 |
T2480 |
nsubj |
regions,shown |
R262 |
T2479 |
T2478 |
amod |
genomic,regions |
R263 |
T2480 |
T2462 |
conj |
shown,carried |
R264 |
T2481 |
T2480 |
aux |
have,shown |
R265 |
T2482 |
T2480 |
dobj |
evidence,shown |
R266 |
T2483 |
T2482 |
prep |
of,evidence |
R267 |
T2484 |
T2483 |
pobj |
linkage,of |
R268 |
T2485 |
T2484 |
prep |
to,linkage |
R269 |
T2486 |
T2487 |
det |
the,disease |
R270 |
T2487 |
T2485 |
pobj |
disease,to |
R271 |
T2488 |
T2480 |
punct |
.,shown |
R272 |
T2490 |
T2491 |
nsubj |
Most,reach |
R273 |
T2492 |
T2490 |
prep |
of,Most |
R274 |
T2493 |
T2494 |
det |
these,regions |
R275 |
T2494 |
T2492 |
pobj |
regions,of |
R276 |
T2495 |
T2494 |
amod |
genomic,regions |
R277 |
T2496 |
T2491 |
aux |
did,reach |
R278 |
T2497 |
T2491 |
neg |
not,reach |
R279 |
T2498 |
T2499 |
det |
a,value |
R280 |
T2499 |
T2491 |
dobj |
value,reach |
R281 |
T2500 |
T2501 |
npadvmod |
genome,wide |
R282 |
T2501 |
T2499 |
amod |
wide,value |
R283 |
T2502 |
T2501 |
punct |
-,wide |
R284 |
T2503 |
T2499 |
amod |
significant,value |
R285 |
T2504 |
T2499 |
compound |
threshold,value |
R286 |
T2505 |
T2499 |
prep |
of,value |
R287 |
T2506 |
T2505 |
pobj |
linkage,of |
R288 |
T2507 |
T2499 |
punct |
", ",value |
R289 |
T2508 |
T2499 |
prep |
with,value |
R290 |
T2509 |
T2510 |
compound |
P,values |
R291 |
T2510 |
T2508 |
pobj |
values,with |
R292 |
T2511 |
T2510 |
prep |
between,values |
R293 |
T2512 |
T2511 |
pobj |
0.05,between |
R294 |
T2513 |
T2512 |
cc |
and,0.05 |
R295 |
T2514 |
T2512 |
conj |
0.001,0.05 |
R296 |
T2515 |
T2516 |
punct |
[,1 |
R297 |
T2516 |
T2491 |
parataxis |
1,reach |
R298 |
T2517 |
T2518 |
punct |
-,5 |
R299 |
T2518 |
T2516 |
prep |
5,1 |
R300 |
T2519 |
T2516 |
punct |
],1 |
R301 |
T2520 |
T2491 |
punct |
.,reach |
R302 |
T2522 |
T2523 |
advmod |
Thus,have |
R303 |
T2524 |
T2523 |
punct |
", ",have |
R304 |
T2525 |
T2526 |
det |
these,loci |
R305 |
T2526 |
T2523 |
nsubj |
loci,have |
R306 |
T2527 |
T2523 |
advmod |
only,have |
R307 |
T2528 |
T2529 |
det |
a,effect |
R308 |
T2529 |
T2523 |
dobj |
effect,have |
R309 |
T2530 |
T2529 |
amod |
small,effect |
R310 |
T2531 |
T2529 |
prep |
on,effect |
R311 |
T2532 |
T2531 |
pobj |
RA,on |
R312 |
T2533 |
T2523 |
punct |
.,have |
R313 |
T2535 |
T2536 |
amod |
Small,contributions |
R314 |
T2536 |
T2538 |
nsubjpass |
contributions,seen |
R315 |
T2537 |
T2536 |
amod |
genetic,contributions |
R316 |
T2539 |
T2538 |
aux |
could,seen |
R317 |
T2540 |
T2538 |
advmod |
also,seen |
R318 |
T2541 |
T2538 |
auxpass |
be,seen |
R319 |
T2542 |
T2538 |
prep |
from,seen |
R320 |
T2543 |
T2544 |
det |
the,genes |
R321 |
T2544 |
T2542 |
pobj |
genes,from |
R322 |
T2545 |
T2544 |
compound |
susceptibility,genes |
R323 |
T2546 |
T2544 |
prep |
of,genes |
R324 |
T2547 |
T2546 |
pobj |
RA,of |
R325 |
T2548 |
T2544 |
acl |
identified,genes |
R326 |
T2549 |
T2550 |
advmod |
so,far |
R327 |
T2550 |
T2548 |
advmod |
far,identified |
R328 |
T2551 |
T2544 |
punct |
", ",genes |
R329 |
T2552 |
T2544 |
prep |
including,genes |
R330 |
T2553 |
T2554 |
compound |
HLA,DR4 |
R331 |
T2554 |
T2552 |
pobj |
DR4,including |
R332 |
T2555 |
T2554 |
punct |
-,DR4 |
R333 |
T2556 |
T2554 |
punct |
", ",DR4 |
R334 |
T2557 |
T2554 |
conj |
PADI4,DR4 |
R335 |
T2558 |
T2557 |
punct |
", ",PADI4 |
R336 |
T2559 |
T2557 |
conj |
PTPN22,PADI4 |
R337 |
T2560 |
T2559 |
cc |
and,PTPN22 |
R338 |
T2561 |
T2559 |
conj |
FCRL3,PTPN22 |
R339 |
T2562 |
T2563 |
punct |
[,6 |
R340 |
T2563 |
T2538 |
parataxis |
6,seen |
R341 |
T2564 |
T2565 |
punct |
-,9 |
R342 |
T2565 |
T2563 |
prep |
9,6 |
R343 |
T2566 |
T2563 |
punct |
],6 |
R344 |
T2567 |
T2538 |
punct |
.,seen |
R345 |
T2569 |
T2570 |
prep |
Except,have |
R346 |
T2571 |
T2569 |
prep |
for,Except |
R347 |
T2572 |
T2573 |
compound |
HLA,DR4 |
R348 |
T2573 |
T2571 |
pobj |
DR4,for |
R349 |
T2574 |
T2573 |
punct |
-,DR4 |
R350 |
T2575 |
T2573 |
punct |
", ",DR4 |
R351 |
T2576 |
T2577 |
dep |
which,associated |
R352 |
T2577 |
T2573 |
relcl |
associated,DR4 |
R353 |
T2578 |
T2577 |
auxpass |
is,associated |
R354 |
T2579 |
T2577 |
advmod |
strongly,associated |
R355 |
T2580 |
T2577 |
prep |
with,associated |
R356 |
T2581 |
T2580 |
pobj |
RA,with |
R357 |
T2582 |
T2570 |
punct |
", ",have |
R358 |
T2583 |
T2584 |
predet |
all,genes |
R359 |
T2584 |
T2570 |
nsubj |
genes,have |
R360 |
T2585 |
T2584 |
det |
the,genes |
R361 |
T2586 |
T2584 |
amod |
other,genes |
R362 |
T2587 |
T2584 |
compound |
susceptibility,genes |
R363 |
T2588 |
T2589 |
advmod |
only,effect |
R364 |
T2589 |
T2570 |
dobj |
effect,have |
R365 |
T2590 |
T2589 |
det |
a,effect |
R366 |
T2591 |
T2589 |
amod |
small,effect |
R367 |
T2592 |
T2589 |
prep |
on,effect |
R368 |
T2593 |
T2594 |
det |
the,disease |
R369 |
T2660 |
T2657 |
punct |
", ",QTL |
R370 |
T2594 |
T2592 |
pobj |
disease,on |
R371 |
T2661 |
T2657 |
appos |
Cia2,QTL |
R372 |
T2595 |
T2570 |
punct |
.,have |
R373 |
T2662 |
T2659 |
punct |
", ",identified |
R374 |
T2663 |
T2659 |
auxpass |
was,identified |
R375 |
T2597 |
T2598 |
prep |
In,observed |
R376 |
T2664 |
T2659 |
prep |
for,identified |
R377 |
T2665 |
T2666 |
det |
the,phenotype |
R378 |
T2666 |
T2664 |
pobj |
phenotype,for |
R379 |
T2599 |
T2600 |
det |
the,model |
R380 |
T2667 |
T2666 |
prep |
of,phenotype |
R381 |
T2668 |
T2669 |
compound |
CIA,severity |
R382 |
T2669 |
T2667 |
pobj |
severity,of |
R383 |
T2670 |
T2659 |
punct |
", ",identified |
R384 |
T2600 |
T2597 |
pobj |
model,In |
R385 |
T2671 |
T2659 |
cc |
but,identified |
R386 |
T2672 |
T2673 |
det |
this,QTL |
R387 |
T2673 |
T2674 |
nsubj |
QTL,contributes |
R388 |
T2674 |
T2659 |
conj |
contributes,identified |
R389 |
T2601 |
T2600 |
compound |
mouse,model |
R390 |
T2675 |
T2674 |
prep |
to,contributes |
R391 |
T2676 |
T2677 |
advmod |
only,16 |
R392 |
T2602 |
T2600 |
prep |
of,model |
R393 |
T2677 |
T2678 |
nummod |
16,% |
R394 |
T2678 |
T2675 |
pobj |
%,to |
R395 |
T2679 |
T2678 |
prep |
of,% |
R396 |
T2603 |
T2602 |
pobj |
RA,of |
R397 |
T2680 |
T2681 |
det |
the,variations |
R398 |
T2681 |
T2679 |
pobj |
variations,of |
R399 |
T2682 |
T2681 |
compound |
phenotype,variations |
R400 |
T2604 |
T2598 |
punct |
", ",observed |
R401 |
T2683 |
T2681 |
prep |
for,variations |
R402 |
T2684 |
T2685 |
compound |
CIA,susceptibility |
R403 |
T2685 |
T2683 |
pobj |
susceptibility,for |
R404 |
T2605 |
T2606 |
amod |
small,contributions |
R405 |
T2686 |
T2674 |
prep |
in,contributes |
R406 |
T2687 |
T2688 |
compound |
F2,progeny |
R407 |
T2606 |
T2598 |
nsubjpass |
contributions,observed |
R408 |
T2688 |
T2686 |
pobj |
progeny,in |
R409 |
T2607 |
T2606 |
amod |
genetic,contributions |
R410 |
T2608 |
T2598 |
auxpass |
are,observed |
R411 |
T2689 |
T2690 |
punct |
[,10 |
R412 |
T2609 |
T2610 |
advmod |
also,often |
R413 |
T2690 |
T2674 |
parataxis |
10,contributes |
R414 |
T2691 |
T2690 |
punct |
],10 |
R415 |
T2692 |
T2674 |
punct |
.,contributes |
R416 |
T2610 |
T2598 |
advmod |
often,observed |
R417 |
T2694 |
T2695 |
nsubj |
This,suggests |
R418 |
T2696 |
T2697 |
mark |
that,be |
R419 |
T2697 |
T2695 |
ccomp |
be,suggests |
R420 |
T2698 |
T2697 |
expl |
there,be |
R421 |
T2611 |
T2598 |
punct |
.,observed |
R422 |
T2699 |
T2697 |
aux |
must,be |
R423 |
T2700 |
T2701 |
amod |
other,genes |
R424 |
T2613 |
T2614 |
prep |
For,carried |
R425 |
T2701 |
T2697 |
attr |
genes,be |
R426 |
T2702 |
T2701 |
compound |
susceptibility,genes |
R427 |
T2703 |
T2704 |
poss |
whose,contributions |
R428 |
T2704 |
T2705 |
dep |
contributions,were |
R429 |
T2705 |
T2701 |
relcl |
were,genes |
R430 |
T2615 |
T2613 |
pobj |
example,For |
R431 |
T2706 |
T2705 |
neg |
not,were |
R432 |
T2707 |
T2705 |
acomp |
big,were |
R433 |
T2708 |
T2707 |
advmod |
enough,big |
R434 |
T2616 |
T2614 |
punct |
", ",carried |
R435 |
T2709 |
T2710 |
aux |
to,reach |
R436 |
T2710 |
T2707 |
xcomp |
reach,big |
R437 |
T2711 |
T2712 |
det |
the,value |
R438 |
T2617 |
T2614 |
prep |
in,carried |
R439 |
T2712 |
T2710 |
dobj |
value,reach |
R440 |
T2713 |
T2712 |
amod |
stringent,value |
R441 |
T2714 |
T2712 |
compound |
significance,value |
R442 |
T2715 |
T2712 |
compound |
threshold,value |
R443 |
T2618 |
T2619 |
det |
a,study |
R444 |
T2716 |
T2712 |
prep |
of,value |
R445 |
T2717 |
T2718 |
compound |
linkage,analysis |
R446 |
T2619 |
T2617 |
pobj |
study,in |
R447 |
T2718 |
T2716 |
pobj |
analysis,of |
R448 |
T2719 |
T2695 |
punct |
.,suggests |
R449 |
T2620 |
T2619 |
amod |
previous,study |
R450 |
T2721 |
T2722 |
nummod |
One,aim |
R451 |
T2722 |
T2723 |
nsubj |
aim,is |
R452 |
T2621 |
T2614 |
punct |
", ",carried |
R453 |
T2724 |
T2722 |
prep |
of,aim |
R454 |
T2725 |
T2724 |
pcomp |
using,of |
R455 |
T2622 |
T2614 |
nsubj |
we,carried |
R456 |
T2726 |
T2727 |
compound |
animal,models |
R457 |
T2727 |
T2725 |
dobj |
models,using |
R458 |
T2728 |
T2725 |
prep |
for,using |
R459 |
T2623 |
T2614 |
prt |
out,carried |
R460 |
T2729 |
T2730 |
amod |
complex,diseases |
R461 |
T2730 |
T2728 |
pobj |
diseases,for |
R462 |
T2624 |
T2625 |
det |
a,screen |
R463 |
T2731 |
T2732 |
aux |
to,detect |
R464 |
T2732 |
T2723 |
xcomp |
detect,is |
R465 |
T2625 |
T2614 |
dobj |
screen,carried |
R466 |
T2733 |
T2734 |
det |
the,basis |
R467 |
T2734 |
T2732 |
dobj |
basis,detect |
R468 |
T2735 |
T2734 |
amod |
genetic,basis |
R469 |
T2736 |
T2734 |
prep |
of,basis |
R470 |
T2737 |
T2738 |
det |
these,diseases |
R471 |
T2738 |
T2736 |
pobj |
diseases,of |
R472 |
T2739 |
T2723 |
punct |
.,is |
R473 |
T2626 |
T2625 |
compound |
genome,screen |
R474 |
T2741 |
T2742 |
prep |
With,are |
R475 |
T2627 |
T2628 |
aux |
to,identify |
R476 |
T2743 |
T2744 |
amod |
controllable,factors |
R477 |
T2744 |
T2741 |
pobj |
factors,With |
R478 |
T2628 |
T2614 |
advcl |
identify,carried |
R479 |
T2745 |
T2744 |
amod |
environmental,factors |
R480 |
T2746 |
T2747 |
advmod |
as,as |
R481 |
T2747 |
T2744 |
cc |
as,factors |
R482 |
T2629 |
T2630 |
det |
the,loci |
R483 |
T2748 |
T2747 |
advmod |
well,as |
R484 |
T2749 |
T2750 |
det |
the,background |
R485 |
T2750 |
T2744 |
conj |
background,factors |
R486 |
T2630 |
T2628 |
dobj |
loci,identify |
R487 |
T2751 |
T2750 |
amod |
known,background |
R488 |
T2752 |
T2750 |
amod |
genetic,background |
R489 |
T2753 |
T2742 |
punct |
", ",are |
R490 |
T2631 |
T2632 |
amod |
quantitative,trait |
R491 |
T2754 |
T2755 |
compound |
animal,models |
R492 |
T2755 |
T2742 |
nsubj |
models,are |
R493 |
T2756 |
T2757 |
amod |
powerful,tools |
R494 |
T2632 |
T2630 |
compound |
trait,loci |
R495 |
T2633 |
T2630 |
punct |
(,loci |
R496 |
T2757 |
T2742 |
attr |
tools,are |
R497 |
T2634 |
T2630 |
appos |
QTL,loci |
R498 |
T2758 |
T2759 |
aux |
to,search |
R499 |
T2759 |
T2757 |
advcl |
search,tools |
R500 |
T2635 |
T2628 |
punct |
),identify |
R501 |
T2760 |
T2759 |
prep |
for,search |
R502 |
T2761 |
T2762 |
compound |
susceptibility,genes |
R503 |
T2762 |
T2760 |
pobj |
genes,for |
R504 |
T2636 |
T2628 |
prep |
in,identify |
R505 |
T2763 |
T2762 |
prep |
for,genes |
R506 |
T2764 |
T2765 |
amod |
complex,diseases |
R507 |
T2765 |
T2763 |
pobj |
diseases,for |
R508 |
T2637 |
T2638 |
npadvmod |
collagen,induced |
R509 |
T2638 |
T2640 |
amod |
induced,arthritis |
R510 |
T2639 |
T2638 |
punct |
-,induced |
R511 |
T2640 |
T2636 |
pobj |
arthritis,in |
R512 |
T2766 |
T2742 |
punct |
", ",are |
R513 |
T2767 |
T2742 |
cc |
and,are |
R514 |
T2768 |
T2769 |
aux |
have,employed |
R515 |
T2641 |
T2640 |
punct |
(,arthritis |
R516 |
T2769 |
T2742 |
conj |
employed,are |
R517 |
T2770 |
T2769 |
auxpass |
been,employed |
R518 |
T2642 |
T2640 |
appos |
CIA,arthritis |
R519 |
T2771 |
T2769 |
advmod |
intensively,employed |
R520 |
T2772 |
T2769 |
prep |
for,employed |
R521 |
T2773 |
T2774 |
det |
that,purpose |
R522 |
T2774 |
T2772 |
pobj |
purpose,for |
R523 |
T2775 |
T2742 |
punct |
.,are |
R524 |
T2643 |
T2640 |
punct |
),arthritis |
R525 |
T2644 |
T2640 |
punct |
", ",arthritis |
R526 |
T2777 |
T2778 |
amod |
More,"27,000" |
R527 |
T2778 |
T2780 |
nummod |
"27,000",QTL |
R528 |
T2779 |
T2778 |
quantmod |
than,"27,000" |
R529 |
T2645 |
T2646 |
dep |
which,is |
R530 |
T2780 |
T2781 |
nsubjpass |
QTL,identified |
R531 |
T2646 |
T2640 |
relcl |
is,arthritis |
R532 |
T2782 |
T2781 |
aux |
have,identified |
R533 |
T2783 |
T2781 |
auxpass |
been,identified |
R534 |
T2784 |
T2781 |
prep |
in,identified |
R535 |
T2647 |
T2648 |
det |
a,model |
R536 |
T2785 |
T2786 |
det |
the,genome |
R537 |
T2786 |
T2784 |
pobj |
genome,in |
R538 |
T2648 |
T2646 |
attr |
model,is |
R539 |
T2787 |
T2786 |
compound |
mouse,genome |
R540 |
T2788 |
T2789 |
mark |
since,identified |
R541 |
T2789 |
T2781 |
advcl |
identified,identified |
R542 |
T2649 |
T2650 |
advmod |
widely,used |
R543 |
T2790 |
T2791 |
det |
the,QTL |
R544 |
T2791 |
T2789 |
nsubjpass |
QTL,identified |
R545 |
T2792 |
T2791 |
amod |
first,QTL |
R546 |
T2650 |
T2648 |
amod |
used,model |
R547 |
T2793 |
T2789 |
auxpass |
was,identified |
R548 |
T2794 |
T2789 |
prep |
at,identified |
R549 |
T2651 |
T2648 |
compound |
animal,model |
R550 |
T2795 |
T2796 |
det |
the,beginning |
R551 |
T2796 |
T2794 |
pobj |
beginning,at |
R552 |
T2797 |
T2796 |
prep |
of,beginning |
R553 |
T2798 |
T2799 |
det |
the,1990s |
R554 |
T2652 |
T2648 |
prep |
of,model |
R555 |
T2799 |
T2797 |
pobj |
1990s,of |
R556 |
T2800 |
T2801 |
punct |
[,11 |
R557 |
T2653 |
T2652 |
pobj |
RA,of |
R558 |
T2801 |
T2781 |
parataxis |
11,identified |
R559 |
T2802 |
T2801 |
punct |
],11 |
R560 |
T2803 |
T2781 |
punct |
.,identified |
R561 |
T2654 |
T2614 |
punct |
.,carried |
R562 |
T2805 |
T2806 |
prep |
By,identified |
R563 |
T2656 |
T2657 |
advmod |
Only,QTL |
R564 |
T2807 |
T2805 |
pobj |
2005,By |
R565 |
T2808 |
T2806 |
punct |
", ",identified |
R566 |
T2809 |
T2810 |
advmod |
approximately,20 |
R567 |
T2810 |
T2811 |
nummod |
20,genes |
R568 |
T2657 |
T2659 |
nsubjpass |
QTL,identified |
R569 |
T2811 |
T2806 |
nsubjpass |
genes,identified |
R570 |
T2812 |
T2813 |
amod |
quantitative,trait |
R571 |
T2813 |
T2811 |
compound |
trait,genes |
R572 |
T2658 |
T2657 |
nummod |
one,QTL |
R573 |
T2814 |
T2811 |
punct |
(,genes |
R574 |
T2815 |
T2811 |
appos |
QTGs,genes |
R575 |
T2816 |
T2811 |
punct |
),genes |
R576 |
T2817 |
T2811 |
prep |
in,genes |
R577 |
T2818 |
T2819 |
det |
the,genome |
R578 |
T2819 |
T2817 |
pobj |
genome,in |
R579 |
T2872 |
T2873 |
amod |
small,effect |
R580 |
T2820 |
T2819 |
compound |
mouse,genome |
R581 |
T2821 |
T2806 |
aux |
had,identified |
R582 |
T2822 |
T2806 |
auxpass |
been,identified |
R583 |
T2823 |
T2824 |
punct |
[,13 |
R584 |
T2824 |
T2806 |
parataxis |
13,identified |
R585 |
T2825 |
T2824 |
nummod |
12,13 |
R586 |
T2873 |
T2875 |
compound |
effect,QTL |
R587 |
T2826 |
T2824 |
punct |
",",13 |
R588 |
T2827 |
T2824 |
punct |
],13 |
R589 |
T2828 |
T2806 |
punct |
.,identified |
R590 |
T2874 |
T2873 |
punct |
-,effect |
R591 |
T2830 |
T2831 |
advmod |
Interestingly,have |
R592 |
T2875 |
T2866 |
nsubj |
QTL,are |
R593 |
T2832 |
T2831 |
punct |
", ",have |
R594 |
T2833 |
T2834 |
amod |
most,QTGs |
R595 |
T2876 |
T2866 |
acomp |
difficult,are |
R596 |
T2834 |
T2831 |
nsubj |
QTGs,have |
R597 |
T2835 |
T2834 |
acl |
identified,QTGs |
R598 |
T2877 |
T2878 |
aux |
to,identify |
R599 |
T2836 |
T2835 |
prep |
in,identified |
R600 |
T2837 |
T2838 |
compound |
animal,models |
R601 |
T2838 |
T2836 |
pobj |
models,in |
R602 |
T2878 |
T2876 |
advcl |
identify,difficult |
R603 |
T2839 |
T2840 |
det |
the,polymorphisms |
R604 |
T2840 |
T2831 |
dobj |
polymorphisms,have |
R605 |
T2879 |
T2878 |
prep |
with,identify |
R606 |
T2841 |
T2840 |
amod |
causal,polymorphisms |
R607 |
T2842 |
T2840 |
prep |
in,polymorphisms |
R608 |
T2843 |
T2844 |
det |
the,region |
R609 |
T2880 |
T2881 |
amod |
traditional,strategies |
R610 |
T2844 |
T2842 |
pobj |
region,in |
R611 |
T2845 |
T2846 |
npadvmod |
protein,coding |
R612 |
T2846 |
T2844 |
amod |
coding,region |
R613 |
T2881 |
T2879 |
pobj |
strategies,with |
R614 |
T2847 |
T2846 |
punct |
-,coding |
R615 |
T2848 |
T2849 |
punct |
[,14 |
R616 |
T2849 |
T2844 |
parataxis |
14,region |
R617 |
T2882 |
T2866 |
cc |
and,are |
R618 |
T2850 |
T2849 |
punct |
],14 |
R619 |
T2851 |
T2840 |
punct |
", ",polymorphisms |
R620 |
T2852 |
T2853 |
dep |
which,provoke |
R621 |
T2883 |
T2866 |
punct |
", ",are |
R622 |
T2853 |
T2840 |
relcl |
provoke,polymorphisms |
R623 |
T2854 |
T2855 |
compound |
protein,changes |
R624 |
T2884 |
T2885 |
prep |
on,affect |
R625 |
T2855 |
T2853 |
dobj |
changes,provoke |
R626 |
T2856 |
T2855 |
compound |
structure,changes |
R627 |
T2857 |
T2855 |
cc |
or,changes |
R628 |
T2858 |
T2859 |
compound |
protein,deficiency |
R629 |
T2859 |
T2855 |
conj |
deficiency,changes |
R630 |
T2860 |
T2831 |
punct |
.,have |
R631 |
T2885 |
T2866 |
conj |
affect,are |
R632 |
T2862 |
T2863 |
nsubj |
This,suggests |
R633 |
T2886 |
T2887 |
det |
the,hand |
R634 |
T2864 |
T2863 |
punct |
", ",suggests |
R635 |
T2887 |
T2884 |
pobj |
hand,on |
R636 |
T2865 |
T2866 |
prep |
on,are |
R637 |
T2888 |
T2887 |
amod |
other,hand |
R638 |
T2866 |
T2863 |
advcl |
are,suggests |
R639 |
T2867 |
T2868 |
det |
the,hand |
R640 |
T2889 |
T2885 |
punct |
", ",affect |
R641 |
T2868 |
T2865 |
pobj |
hand,on |
R642 |
T2869 |
T2868 |
nummod |
one,hand |
R643 |
T2870 |
T2866 |
punct |
", ",are |
R644 |
T2890 |
T2885 |
mark |
that,affect |
R645 |
T2871 |
T2866 |
mark |
that,are |
R646 |
T2891 |
T2892 |
det |
the,polymorphisms |
R647 |
T2892 |
T2885 |
nsubj |
polymorphisms,affect |
R648 |
T2893 |
T2892 |
acl |
regulating,polymorphisms |
R649 |
T2894 |
T2895 |
compound |
gene,expression |
R650 |
T2978 |
T2977 |
amod |
past,decade |
R651 |
T2979 |
T2975 |
punct |
", ",applied |
R652 |
T2895 |
T2893 |
dobj |
expression,regulating |
R653 |
T2980 |
T2981 |
amod |
many,studies |
R654 |
T2981 |
T2975 |
nsubj |
studies,applied |
R655 |
T2896 |
T2885 |
aux |
might,affect |
R656 |
T2982 |
T2983 |
det |
this,technique |
R657 |
T2983 |
T2975 |
dobj |
technique,applied |
R658 |
T2897 |
T2898 |
advmod |
only,slightly |
R659 |
T2984 |
T2985 |
aux |
to,study |
R660 |
T2985 |
T2975 |
advcl |
study,applied |
R661 |
T2986 |
T2987 |
preconj |
both,RA |
R662 |
T2987 |
T2985 |
dobj |
RA,study |
R663 |
T2898 |
T2885 |
advmod |
slightly,affect |
R664 |
T2988 |
T2987 |
cc |
and,RA |
R665 |
T2989 |
T2990 |
poss |
its,models |
R666 |
T2899 |
T2900 |
det |
the,traits |
R667 |
T2990 |
T2987 |
conj |
models,RA |
R668 |
T2991 |
T2990 |
compound |
animal,models |
R669 |
T2992 |
T2993 |
punct |
[,15 |
R670 |
T2900 |
T2885 |
dobj |
traits,affect |
R671 |
T2993 |
T2975 |
parataxis |
15,applied |
R672 |
T2994 |
T2995 |
punct |
-,22 |
R673 |
T2995 |
T2993 |
prep |
22,15 |
R674 |
T2901 |
T2900 |
amod |
quantitative,traits |
R675 |
T2996 |
T2993 |
punct |
],15 |
R676 |
T2997 |
T2975 |
punct |
.,applied |
R677 |
T2902 |
T2885 |
punct |
", ",affect |
R678 |
T2999 |
T3000 |
advmod |
Indeed,show |
R679 |
T3001 |
T3000 |
punct |
", ",show |
R680 |
T3002 |
T3000 |
nsubj |
genes,show |
R681 |
T3003 |
T3002 |
acl |
involved,genes |
R682 |
T2903 |
T2885 |
cc |
and,affect |
R683 |
T3004 |
T3003 |
prep |
in,involved |
R684 |
T3005 |
T3004 |
pobj |
arthritis,in |
R685 |
T3006 |
T3007 |
amod |
distinct,patterns |
R686 |
T3007 |
T3000 |
dobj |
patterns,show |
R687 |
T2904 |
T2905 |
advmod |
thus,are |
R688 |
T3008 |
T3007 |
compound |
expression,patterns |
R689 |
T3009 |
T3007 |
prep |
in,patterns |
R690 |
T3010 |
T3011 |
amod |
certain,tissues |
R691 |
T2905 |
T2885 |
conj |
are,affect |
R692 |
T3011 |
T3009 |
pobj |
tissues,in |
R693 |
T3012 |
T3011 |
cc |
and,tissues |
R694 |
T3013 |
T3014 |
amod |
pathological,stages |
R695 |
T2906 |
T2907 |
advmod |
more,difficult |
R696 |
T3014 |
T3011 |
conj |
stages,tissues |
R697 |
T3015 |
T3014 |
prep |
of,stages |
R698 |
T3016 |
T3017 |
det |
the,disease |
R699 |
T2907 |
T2905 |
acomp |
difficult,are |
R700 |
T3017 |
T3015 |
pobj |
disease,of |
R701 |
T3018 |
T3000 |
punct |
.,show |
R702 |
T2908 |
T2909 |
aux |
to,identify |
R703 |
T3020 |
T3021 |
nsubjpass |
Genes,expressed |
R704 |
T2909 |
T2907 |
advcl |
identify,difficult |
R705 |
T3022 |
T3020 |
acl |
involved,Genes |
R706 |
T3023 |
T3022 |
prep |
in,involved |
R707 |
T3024 |
T3025 |
amod |
immunoinflammatory,responses |
R708 |
T3025 |
T3023 |
pobj |
responses,in |
R709 |
T2910 |
T2863 |
punct |
.,suggests |
R710 |
T3026 |
T3021 |
auxpass |
were,expressed |
R711 |
T3027 |
T3021 |
advmod |
differentially,expressed |
R712 |
T3028 |
T3021 |
prep |
in,expressed |
R713 |
T2912 |
T2913 |
npadvmod |
Microarray,based |
R714 |
T3029 |
T3030 |
det |
the,cells |
R715 |
T3030 |
T3028 |
pobj |
cells,in |
R716 |
T3031 |
T3030 |
compound |
blood,cells |
R717 |
T3032 |
T3021 |
prep |
in,expressed |
R718 |
T2913 |
T2915 |
amod |
based,expression |
R719 |
T3033 |
T3034 |
compound |
RA,patients |
R720 |
T3034 |
T3032 |
pobj |
patients,in |
R721 |
T3035 |
T3036 |
punct |
[,18 |
R722 |
T2914 |
T2913 |
punct |
-,based |
R723 |
T3036 |
T3021 |
parataxis |
18,expressed |
R724 |
T3037 |
T3036 |
punct |
],18 |
R725 |
T3038 |
T3021 |
punct |
.,expressed |
R726 |
T2915 |
T2918 |
nsubj |
expression,is |
R727 |
T2916 |
T2915 |
amod |
global,expression |
R728 |
T2917 |
T2915 |
compound |
gene,expression |
R729 |
T3040 |
T3041 |
nsubjpass |
Chemokines,upregulated |
R730 |
T2919 |
T2920 |
det |
a,technique |
R731 |
T3042 |
T3040 |
cc |
and,Chemokines |
R732 |
T3043 |
T3044 |
compound |
adhesion,molecules |
R733 |
T3044 |
T3040 |
conj |
molecules,Chemokines |
R734 |
T3045 |
T3041 |
auxpass |
were,upregulated |
R735 |
T3046 |
T3041 |
prep |
in,upregulated |
R736 |
T3047 |
T3048 |
det |
the,joint |
R737 |
T3048 |
T3046 |
pobj |
joint,in |
R738 |
T2920 |
T2918 |
attr |
technique,is |
R739 |
T3049 |
T3041 |
prep |
at,upregulated |
R740 |
T3050 |
T3051 |
det |
the,phase |
R741 |
T3051 |
T3049 |
pobj |
phase,at |
R742 |
T2921 |
T2920 |
amod |
powerful,technique |
R743 |
T3052 |
T3051 |
compound |
initiation,phase |
R744 |
T2922 |
T2920 |
prep |
for,technique |
R745 |
T3053 |
T3051 |
prep |
of,phase |
R746 |
T3054 |
T3053 |
pobj |
arthritis,of |
R747 |
T3055 |
T3041 |
prep |
in,upregulated |
R748 |
T3056 |
T3057 |
compound |
animal,models |
R749 |
T2923 |
T2922 |
pcomp |
investigating,for |
R750 |
T3057 |
T3055 |
pobj |
models,in |
R751 |
T3058 |
T3059 |
punct |
[,22 |
R752 |
T3059 |
T3041 |
parataxis |
22,upregulated |
R753 |
T2924 |
T2925 |
amod |
complex,diseases |
R754 |
T3060 |
T3059 |
nummod |
21,22 |
R755 |
T3061 |
T3059 |
punct |
",",22 |
R756 |
T3062 |
T3059 |
punct |
],22 |
R757 |
T2925 |
T2923 |
dobj |
diseases,investigating |
R758 |
T3063 |
T3041 |
punct |
", ",upregulated |
R759 |
T3064 |
T3065 |
mark |
while,expressed |
R760 |
T2926 |
T2918 |
punct |
.,is |
R761 |
T3065 |
T3041 |
advcl |
expressed,upregulated |
R762 |
T3066 |
T3065 |
nsubjpass |
genes,expressed |
R763 |
T3067 |
T3066 |
acl |
involved,genes |
R764 |
T3068 |
T3067 |
prep |
in,involved |
R765 |
T2928 |
T2929 |
prep |
During,are |
R766 |
T3069 |
T3070 |
compound |
cartilage,destruction |
R767 |
T3070 |
T3068 |
pobj |
destruction,in |
R768 |
T3071 |
T3070 |
cc |
and,destruction |
R769 |
T3072 |
T3073 |
compound |
bone,erosion |
R770 |
T2930 |
T2931 |
compound |
disease,development |
R771 |
T3073 |
T3070 |
conj |
erosion,destruction |
R772 |
T3074 |
T3065 |
auxpass |
were,expressed |
R773 |
T3075 |
T3065 |
advmod |
differentially,expressed |
R774 |
T3076 |
T3065 |
prep |
at,expressed |
R775 |
T2931 |
T2928 |
pobj |
development,During |
R776 |
T3077 |
T3078 |
det |
the,phase |
R777 |
T3078 |
T3076 |
pobj |
phase,at |
R778 |
T3079 |
T3078 |
amod |
late,phase |
R779 |
T2932 |
T2929 |
punct |
", ",are |
R780 |
T3080 |
T3078 |
prep |
of,phase |
R781 |
T3081 |
T3080 |
pobj |
arthritis,of |
R782 |
T3082 |
T3065 |
prep |
in,expressed |
R783 |
T2933 |
T2929 |
nsubj |
genes,are |
R784 |
T3083 |
T3084 |
compound |
animal,models |
R785 |
T2934 |
T2933 |
acl |
involved,genes |
R786 |
T2935 |
T2934 |
prep |
in,involved |
R787 |
T3084 |
T3082 |
pobj |
models,in |
R788 |
T2936 |
T2937 |
det |
the,disease |
R789 |
T3085 |
T3084 |
prep |
of,models |
R790 |
T3086 |
T3085 |
pobj |
RA,of |
R791 |
T3087 |
T3088 |
punct |
[,16 |
R792 |
T2937 |
T2935 |
pobj |
disease,in |
R793 |
T3088 |
T3065 |
parataxis |
16,expressed |
R794 |
T3089 |
T3088 |
nummod |
15,16 |
R795 |
T2938 |
T2929 |
acomp |
likely,are |
R796 |
T3090 |
T3088 |
punct |
",",16 |
R797 |
T2939 |
T2940 |
aux |
to,regulated |
R798 |
T3091 |
T3088 |
punct |
],16 |
R799 |
T3092 |
T3041 |
punct |
.,upregulated |
R800 |
T3094 |
T3095 |
mark |
Besides,detecting |
R801 |
T2940 |
T2938 |
xcomp |
regulated,likely |
R802 |
T3095 |
T3096 |
advcl |
detecting,used |
R803 |
T2941 |
T2940 |
auxpass |
be,regulated |
R804 |
T3097 |
T3095 |
dobj |
genes,detecting |
R805 |
T3098 |
T3097 |
acl |
involved,genes |
R806 |
T3099 |
T3098 |
prep |
in,involved |
R807 |
T2942 |
T2940 |
advmod |
differentially,regulated |
R808 |
T3100 |
T3101 |
amod |
complex,diseases |
R809 |
T3101 |
T3099 |
pobj |
diseases,in |
R810 |
T3102 |
T3096 |
punct |
", ",used |
R811 |
T3103 |
T3096 |
nsubjpass |
microarrays,used |
R812 |
T2943 |
T2929 |
punct |
.,are |
R813 |
T3104 |
T3096 |
aux |
could,used |
R814 |
T3105 |
T3096 |
advmod |
also,used |
R815 |
T3106 |
T3096 |
auxpass |
be,used |
R816 |
T2945 |
T2946 |
advmod |
Therefore,identified |
R817 |
T3107 |
T3108 |
aux |
to,detect |
R818 |
T3108 |
T3096 |
advcl |
detect,used |
R819 |
T3109 |
T3110 |
det |
the,polymorphisms |
R820 |
T3110 |
T3108 |
dobj |
polymorphisms,detect |
R821 |
T2947 |
T2946 |
punct |
", ",identified |
R822 |
T3111 |
T3110 |
amod |
genetic,polymorphisms |
R823 |
T3112 |
T3110 |
acl |
regulating,polymorphisms |
R824 |
T3113 |
T3114 |
compound |
gene,expression |
R825 |
T3114 |
T3112 |
dobj |
expression,regulating |
R826 |
T3115 |
T3116 |
mark |
because,be |
R827 |
T2948 |
T2949 |
compound |
signature,genes |
R828 |
T3116 |
T3108 |
advcl |
be,detect |
R829 |
T3117 |
T3118 |
amod |
differential,expressions |
R830 |
T2949 |
T2946 |
nsubjpass |
genes,identified |
R831 |
T3118 |
T3116 |
nsubj |
expressions,be |
R832 |
T3119 |
T3118 |
prep |
between,expressions |
R833 |
T3120 |
T3121 |
nummod |
two,strains |
R834 |
T2950 |
T2949 |
prep |
of,genes |
R835 |
T3121 |
T3119 |
pobj |
strains,between |
R836 |
T3122 |
T3116 |
aux |
might,be |
R837 |
T3123 |
T3124 |
det |
the,result |
R838 |
T3124 |
T3116 |
attr |
result,be |
R839 |
T2951 |
T2952 |
det |
the,diseases |
R840 |
T3125 |
T3124 |
prep |
of,result |
R841 |
T3126 |
T3127 |
det |
a,polymorphism |
R842 |
T3127 |
T3125 |
pobj |
polymorphism,of |
R843 |
T2952 |
T2950 |
pobj |
diseases,of |
R844 |
T3128 |
T3127 |
acl |
located,polymorphism |
R845 |
T3129 |
T3128 |
prep |
in,located |
R846 |
T3130 |
T3131 |
amod |
regulatory,elements |
R847 |
T2953 |
T2946 |
aux |
could,identified |
R848 |
T3131 |
T3129 |
pobj |
elements,in |
R849 |
T3132 |
T3096 |
punct |
.,used |
R850 |
T2954 |
T2946 |
auxpass |
be,identified |
R851 |
T3134 |
T3135 |
aux |
To,identify |
R852 |
T3135 |
T3136 |
advcl |
identify,investigated |
R853 |
T2955 |
T2946 |
prep |
by,identified |
R854 |
T3137 |
T3138 |
det |
the,QTL |
R855 |
T3138 |
T3135 |
dobj |
QTL,identify |
R856 |
T2956 |
T2955 |
pcomp |
detecting,by |
R857 |
T3139 |
T3140 |
amod |
small,effect |
R858 |
T3140 |
T3138 |
compound |
effect,QTL |
R859 |
T3141 |
T3140 |
punct |
-,effect |
R860 |
T3142 |
T3138 |
prep |
of,QTL |
R861 |
T2957 |
T2958 |
det |
the,patterns |
R862 |
T3143 |
T3142 |
pobj |
CIA,of |
R863 |
T3144 |
T3145 |
advmod |
as,as |
R864 |
T3145 |
T3138 |
cc |
as,QTL |
R865 |
T2958 |
T2956 |
dobj |
patterns,detecting |
R866 |
T3146 |
T3145 |
advmod |
well,as |
R867 |
T3147 |
T3148 |
det |
the,genes |
R868 |
T3148 |
T3138 |
conj |
genes,QTL |
R869 |
T2959 |
T2958 |
compound |
expression,patterns |
R870 |
T2960 |
T2958 |
prep |
of,patterns |
R871 |
T3149 |
T3148 |
amod |
potential,genes |
R872 |
T2961 |
T2962 |
det |
the,tissues |
R873 |
T3150 |
T3148 |
compound |
candidate,genes |
R874 |
T3151 |
T3148 |
prep |
inside,genes |
R875 |
T3152 |
T3151 |
pobj |
them,inside |
R876 |
T2962 |
T2960 |
pobj |
tissues,of |
R877 |
T3153 |
T3136 |
punct |
", ",investigated |
R878 |
T3154 |
T3136 |
nsubj |
we,investigated |
R879 |
T2963 |
T2964 |
npadvmod |
disease,related |
R880 |
T3155 |
T3156 |
npadvmod |
CIA,susceptible |
R881 |
T3156 |
T3158 |
amod |
susceptible,strains |
R882 |
T3157 |
T3156 |
advmod |
genetically,susceptible |
R883 |
T2964 |
T2962 |
amod |
related,tissues |
R884 |
T3158 |
T3136 |
dobj |
strains,investigated |
R885 |
T3159 |
T3156 |
cc |
and,susceptible |
R886 |
T3160 |
T3156 |
conj |
resistant,susceptible |
R887 |
T2965 |
T2964 |
punct |
-,related |
R888 |
T3161 |
T3136 |
prep |
at,investigated |
R889 |
T3162 |
T3163 |
preconj |
both,genome |
R890 |
T3163 |
T3165 |
nmod |
genome,levels |
R891 |
T3164 |
T3163 |
det |
the,genome |
R892 |
T3165 |
T3161 |
pobj |
levels,at |
R893 |
T3166 |
T3163 |
cc |
and,genome |
R894 |
T3167 |
T3163 |
conj |
transcriptome,genome |
R895 |
T2966 |
T2962 |
compound |
cells,tissues |
R896 |
T3168 |
T3136 |
punct |
.,investigated |
R897 |
T3170 |
T3171 |
prep |
At,generated |
R898 |
T2967 |
T2962 |
punct |
/,tissues |
R899 |
T3172 |
T3173 |
det |
the,level |
R900 |
T3173 |
T3170 |
pobj |
level,At |
R901 |
T2968 |
T2962 |
cc |
and,tissues |
R902 |
T3174 |
T3173 |
compound |
genome,level |
R903 |
T2969 |
T2970 |
poss |
their,controls |
R904 |
T3175 |
T3171 |
punct |
", ",generated |
R905 |
T3176 |
T3177 |
compound |
F2,progeny |
R906 |
T3177 |
T3171 |
nsubjpass |
progeny,generated |
R907 |
T3178 |
T3177 |
prep |
of,progeny |
R908 |
T2970 |
T2962 |
conj |
controls,tissues |
R909 |
T3179 |
T3180 |
det |
the,strains |
R910 |
T3180 |
T3178 |
pobj |
strains,of |
R911 |
T3181 |
T3180 |
amod |
CIA,strains |
R912 |
T2971 |
T2970 |
amod |
ideal,controls |
R913 |
T3182 |
T3181 |
amod |
susceptible,CIA |
R914 |
T3183 |
T3184 |
punct |
(,DBA |
R915 |
T3184 |
T3182 |
parataxis |
DBA,susceptible |
R916 |
T2972 |
T2946 |
punct |
.,identified |
R917 |
T3185 |
T3184 |
punct |
/,DBA |
R918 |
T3186 |
T3184 |
nummod |
1,DBA |
R919 |
T3187 |
T3184 |
punct |
),DBA |
R920 |
T2974 |
T2975 |
prep |
In,applied |
R921 |
T3188 |
T3181 |
cc |
and,CIA |
R922 |
T3189 |
T3181 |
conj |
resistant,CIA |
R923 |
T2976 |
T2977 |
det |
the,decade |
R924 |
T2977 |
T2974 |
pobj |
decade,In |
R925 |
T3190 |
T3191 |
punct |
(,N |
R926 |
T3191 |
T3189 |
parataxis |
N,resistant |
R927 |
T3192 |
T3191 |
compound |
FVB,N |
R928 |
T3193 |
T3191 |
punct |
/,N |
R929 |
T3194 |
T3191 |
punct |
),N |
R930 |
T3195 |
T3171 |
auxpass |
were,generated |
R931 |
T3196 |
T3171 |
cc |
and,generated |
R932 |
T3197 |
T3198 |
det |
a,analysis |
R933 |
T3198 |
T3203 |
nsubjpass |
analysis,performed |
R934 |
T3199 |
T3200 |
npadvmod |
genome,wide |
R935 |
T3200 |
T3198 |
amod |
wide,analysis |
R936 |
T3201 |
T3200 |
punct |
-,wide |
R937 |
T3202 |
T3198 |
compound |
linkage,analysis |
R938 |
T3203 |
T3171 |
conj |
performed,generated |
R939 |
T3204 |
T3203 |
auxpass |
was,performed |
R940 |
T3205 |
T3206 |
aux |
to,identify |
R941 |
T3206 |
T3203 |
advcl |
identify,performed |
R942 |
T3207 |
T3208 |
amod |
small,effect |
R943 |
T3208 |
T3210 |
compound |
effect,QTL |
R944 |
T3209 |
T3208 |
punct |
-,effect |
R945 |
T3210 |
T3206 |
dobj |
QTL,identify |
R946 |
T3211 |
T3203 |
punct |
.,performed |
R947 |
T3213 |
T3214 |
prep |
At,detected |
R948 |
T3215 |
T3216 |
det |
the,level |
R949 |
T3216 |
T3213 |
pobj |
level,At |
R950 |
T3217 |
T3216 |
compound |
transcriptome,level |
R951 |
T3218 |
T3214 |
punct |
", ",detected |
R952 |
T3219 |
T3214 |
nsubj |
we,detected |
R953 |
T3220 |
T3221 |
det |
the,patterns |
R954 |
T3221 |
T3214 |
dobj |
patterns,detected |
R955 |
T3222 |
T3223 |
compound |
gene,expression |
R956 |
T3223 |
T3221 |
compound |
expression,patterns |
R957 |
T3224 |
T3221 |
prep |
of,patterns |
R958 |
T3225 |
T3226 |
preconj |
both,strains |
R959 |
T3226 |
T3224 |
pobj |
strains,of |
R960 |
T3227 |
T3226 |
det |
the,strains |
R961 |
T3228 |
T3226 |
nmod |
DBA,strains |
R962 |
T3229 |
T3228 |
punct |
/,DBA |
R963 |
T3230 |
T3228 |
nummod |
1,DBA |
R964 |
T3231 |
T3228 |
cc |
and,DBA |
R965 |
T3232 |
T3233 |
compound |
FVB,N |
R966 |
T3233 |
T3228 |
conj |
N,DBA |
R967 |
T3234 |
T3233 |
punct |
/,N |
R968 |
T3235 |
T3214 |
prep |
at,detected |
R969 |
T3236 |
T3237 |
nummod |
four,phases |
R970 |
T3237 |
T3235 |
pobj |
phases,at |
R971 |
T3238 |
T3237 |
amod |
different,phases |
R972 |
T3239 |
T3237 |
prep |
of,phases |
R973 |
T3240 |
T3239 |
pobj |
CIA,of |
R974 |
T3241 |
T3214 |
punct |
.,detected |
R975 |
T3243 |
T3244 |
det |
The,genes |
R976 |
T3244 |
T3247 |
nsubjpass |
genes,identified |
R977 |
T3245 |
T3244 |
amod |
potential,genes |
R978 |
T3246 |
T3244 |
compound |
candidate,genes |
R979 |
T3247 |
T3249 |
ccomp |
identified,located |
R980 |
T3248 |
T3247 |
auxpass |
were,identified |
R981 |
T3250 |
T3247 |
prep |
based,identified |
R982 |
T3251 |
T3250 |
prep |
on,based |
R983 |
T3252 |
T3253 |
nummod |
three,criteria |
R984 |
T3253 |
T3251 |
pobj |
criteria,on |
R985 |
T3254 |
T3249 |
punct |
: ,located |
R986 |
T3255 |
T3249 |
nsubjpass |
they,located |
R987 |
T3256 |
T3249 |
auxpass |
are,located |
R988 |
T3257 |
T3249 |
prep |
within,located |
R989 |
T3258 |
T3259 |
det |
the,region |
R990 |
T3259 |
T3257 |
pobj |
region,within |
R991 |
T3260 |
T3259 |
amod |
genomic,region |
R992 |
T3261 |
T3259 |
acl |
linked,region |
R993 |
T3262 |
T3261 |
prep |
to,linked |
R994 |
T3263 |
T3262 |
pobj |
CIA,to |
R995 |
T3264 |
T3249 |
punct |
;,located |
R996 |
T3265 |
T3266 |
nsubjpass |
they,expressed |
R997 |
T3266 |
T3249 |
conj |
expressed,located |
R998 |
T3267 |
T3266 |
auxpass |
are,expressed |
R999 |
T3268 |
T3269 |
npadvmod |
disease,specific |