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PMC:1635039 / 149-1325 JSONTXT 4 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T535 0-10 sentence denotes Background
T536 0-10 NN denotes Background
T537 10-98 sentence denotes Congenital cardiovascular diseases are the most common form of birth defects in humans.
T538 11-21 JJ denotes Congenital
T540 22-36 JJ denotes cardiovascular
T539 37-45 NNS denotes diseases
T541 46-49 VBP denotes are
T542 50-53 DT denotes the
T544 54-58 RBS denotes most
T545 59-65 JJ denotes common
T543 66-70 NN denotes form
T546 71-73 IN denotes of
T547 74-79 NN denotes birth
T548 80-87 NNS denotes defects
T549 88-90 IN denotes in
T550 91-97 NNS denotes humans
T551 97-98 . denotes .
T552 98-277 sentence denotes A substantial portion of these defects has been associated with inappropriate induction, migration, differentiation and patterning of pluripotent cardiac neural crest stem cells.
T553 99-100 DT denotes A
T555 101-112 JJ denotes substantial
T554 113-120 NN denotes portion
T557 121-123 IN denotes of
T558 124-129 DT denotes these
T559 130-137 NNS denotes defects
T560 138-141 VBZ denotes has
T561 142-146 VBN denotes been
T556 147-157 VBN denotes associated
T562 158-162 IN denotes with
T563 163-176 JJ denotes inappropriate
T564 177-186 NN denotes induction
T565 186-188 , denotes ,
T566 188-197 NN denotes migration
T567 197-199 , denotes ,
T568 199-214 NN denotes differentiation
T569 215-218 CC denotes and
T570 219-229 NN denotes patterning
T571 230-232 IN denotes of
T572 233-244 JJ denotes pluripotent
T574 245-252 JJ denotes cardiac
T576 253-259 JJ denotes neural
T575 260-265 NN denotes crest
T577 266-270 NN denotes stem
T573 271-276 NNS denotes cells
T578 276-277 . denotes .
T579 277-455 sentence denotes While TGF-β-superfamily signaling has been strongly implicated in neural crest cell development, the detailed molecular signaling mechanisms in vivo are still poorly understood.
T580 278-283 IN denotes While
T582 284-287 NN denotes TGF
T584 287-288 HYPH denotes -
T583 288-289 NN denotes β
T586 289-290 HYPH denotes -
T585 290-301 NN denotes superfamily
T587 302-311 NN denotes signaling
T588 312-315 VBZ denotes has
T589 316-320 VBN denotes been
T590 321-329 RB denotes strongly
T581 330-340 VBN denotes implicated
T592 341-343 IN denotes in
T593 344-350 JJ denotes neural
T595 351-356 NN denotes crest
T594 357-361 NN denotes cell
T596 362-373 NN denotes development
T597 373-375 , denotes ,
T598 375-378 DT denotes the
T600 379-387 JJ denotes detailed
T601 388-397 JJ denotes molecular
T602 398-407 NN denotes signaling
T599 408-418 NNS denotes mechanisms
T603 419-421 FW denotes in
T604 422-426 FW denotes vivo
T605 427-430 VBP denotes are
T606 431-436 RB denotes still
T607 437-443 RB denotes poorly
T591 444-454 VBN denotes understood
T608 454-455 . denotes .
T609 455-464 sentence denotes Results
T610 457-464 NNS denotes Results
T611 464-559 sentence denotes We deleted the TGF-β type I receptor Alk5 specifically in the mouse neural crest cell lineage.
T612 465-467 PRP denotes We
T613 468-475 VBD denotes deleted
T614 476-479 DT denotes the
T616 480-483 NN denotes TGF
T618 483-484 HYPH denotes -
T617 484-485 NN denotes β
T619 486-490 NN denotes type
T620 491-492 CD denotes I
T621 493-501 NN denotes receptor
T615 502-506 NN denotes Alk5
T622 507-519 RB denotes specifically
T623 520-522 IN denotes in
T624 523-526 DT denotes the
T626 527-532 NN denotes mouse
T627 533-539 JJ denotes neural
T629 540-545 NN denotes crest
T628 546-550 NN denotes cell
T625 551-558 NN denotes lineage
T630 558-559 . denotes .
T631 559-814 sentence denotes Failure in signaling via ALK5 leads to severe cardiovascular and pharyngeal defects, including inappropriate remodeling of pharyngeal arch arteries, abnormal aortic sac development, failure in pharyngeal organ migration and persistent truncus arteriosus.
T632 560-567 NN denotes Failure
T634 568-570 IN denotes in
T635 571-580 NN denotes signaling
T636 581-584 IN denotes via
T637 585-589 NN denotes ALK5
T633 590-595 VBZ denotes leads
T638 596-598 IN denotes to
T639 599-605 JJ denotes severe
T641 606-620 JJ denotes cardiovascular
T642 621-624 CC denotes and
T643 625-635 JJ denotes pharyngeal
T640 636-643 NNS denotes defects
T644 643-645 , denotes ,
T645 645-654 VBG denotes including
T646 655-668 JJ denotes inappropriate
T647 669-679 NN denotes remodeling
T648 680-682 IN denotes of
T649 683-693 JJ denotes pharyngeal
T651 694-698 NN denotes arch
T650 699-707 NNS denotes arteries
T652 707-709 , denotes ,
T653 709-717 JJ denotes abnormal
T655 718-724 JJ denotes aortic
T656 725-728 NN denotes sac
T654 729-740 NN denotes development
T657 740-742 , denotes ,
T658 742-749 NN denotes failure
T659 750-752 IN denotes in
T660 753-763 JJ denotes pharyngeal
T662 764-769 NN denotes organ
T661 770-779 NN denotes migration
T663 780-783 CC denotes and
T664 784-794 JJ denotes persistent
T666 795-802 NN denotes truncus
T665 803-813 NN denotes arteriosus
T667 813-814 . denotes .
T668 814-992 sentence denotes While ALK5 is not required for neural crest cell migration, our results demonstrate that it plays an important role in the survival of post-migratory cardiac neural crest cells.
T669 815-820 IN denotes While
T671 821-825 NN denotes ALK5
T672 826-828 VBZ denotes is
T673 829-832 RB denotes not
T670 833-841 VBN denotes required
T675 842-845 IN denotes for
T676 846-852 JJ denotes neural
T678 853-858 NN denotes crest
T677 859-863 NN denotes cell
T679 864-873 NN denotes migration
T680 873-875 , denotes ,
T681 875-878 PRP$ denotes our
T682 879-886 NNS denotes results
T674 887-898 VBP denotes demonstrate
T683 899-903 IN denotes that
T685 904-906 PRP denotes it
T684 907-912 VBZ denotes plays
T686 913-915 DT denotes an
T688 916-925 JJ denotes important
T687 926-930 NN denotes role
T689 931-933 IN denotes in
T690 934-937 DT denotes the
T691 938-946 NN denotes survival
T692 947-949 IN denotes of
T693 950-964 JJ denotes post-migratory
T695 965-972 JJ denotes cardiac
T697 973-979 JJ denotes neural
T696 980-985 NN denotes crest
T694 986-991 NNS denotes cells
T698 991-992 . denotes .
T699 992-1004 sentence denotes Conclusion
T700 994-1004 NN denotes Conclusion
T701 1004-1176 sentence denotes Our results demonstrate that ALK5-mediated signaling in neural crest cells plays an essential cell-autonomous role in the pharyngeal and cardiac outflow tract development.
T702 1005-1008 PRP$ denotes Our
T703 1009-1016 NNS denotes results
T704 1017-1028 VBP denotes demonstrate
T705 1029-1033 IN denotes that
T707 1034-1038 NN denotes ALK5
T709 1038-1039 HYPH denotes -
T708 1039-1047 VBN denotes mediated
T710 1048-1057 NN denotes signaling
T711 1058-1060 IN denotes in
T712 1061-1067 JJ denotes neural
T714 1068-1073 NN denotes crest
T713 1074-1079 NNS denotes cells
T706 1080-1085 VBZ denotes plays
T715 1086-1088 DT denotes an
T717 1089-1098 JJ denotes essential
T718 1099-1103 NN denotes cell
T720 1103-1104 HYPH denotes -
T719 1104-1114 JJ denotes autonomous
T716 1115-1119 NN denotes role
T721 1120-1122 IN denotes in
T722 1123-1126 DT denotes the
T724 1127-1137 JJ denotes pharyngeal
T726 1138-1141 CC denotes and
T727 1142-1149 JJ denotes cardiac
T728 1150-1157 NN denotes outflow
T725 1158-1163 NN denotes tract
T723 1164-1175 NN denotes development
T729 1175-1176 . denotes .
R100 T612 T613 nsubj We,deleted
R101 T614 T615 det the,Alk5
R102 T615 T613 dobj Alk5,deleted
R103 T616 T617 nmod TGF,β
R104 T617 T615 nmod β,Alk5
R105 T618 T617 punct -,β
R106 T619 T615 nmod type,Alk5
R107 T620 T619 nummod I,type
R108 T621 T615 compound receptor,Alk5
R109 T622 T613 advmod specifically,deleted
R110 T623 T613 prep in,deleted
R111 T624 T625 det the,lineage
R112 T625 T623 pobj lineage,in
R113 T626 T625 nmod mouse,lineage
R114 T627 T628 amod neural,cell
R115 T628 T625 compound cell,lineage
R116 T629 T628 compound crest,cell
R117 T630 T613 punct .,deleted
R118 T632 T633 nsubj Failure,leads
R119 T634 T632 prep in,Failure
R120 T635 T634 pobj signaling,in
R121 T636 T632 prep via,Failure
R122 T637 T636 pobj ALK5,via
R123 T638 T633 prep to,leads
R124 T639 T640 amod severe,defects
R125 T640 T638 pobj defects,to
R126 T641 T640 amod cardiovascular,defects
R127 T642 T641 cc and,cardiovascular
R128 T643 T641 conj pharyngeal,cardiovascular
R129 T644 T640 punct ", ",defects
R130 T645 T640 prep including,defects
R131 T646 T647 amod inappropriate,remodeling
R132 T647 T645 pobj remodeling,including
R133 T648 T647 prep of,remodeling
R134 T649 T650 amod pharyngeal,arteries
R135 T650 T648 pobj arteries,of
R136 T651 T650 compound arch,arteries
R137 T652 T647 punct ", ",remodeling
R138 T653 T654 amod abnormal,development
R139 T654 T647 appos development,remodeling
R140 T655 T656 amod aortic,sac
R141 T656 T654 compound sac,development
R142 T657 T647 punct ", ",remodeling
R143 T658 T647 appos failure,remodeling
R144 T659 T658 prep in,failure
R145 T660 T661 amod pharyngeal,migration
R146 T661 T659 pobj migration,in
R147 T662 T661 compound organ,migration
R148 T663 T661 cc and,migration
R149 T664 T665 amod persistent,arteriosus
R150 T665 T661 conj arteriosus,migration
R151 T666 T665 compound truncus,arteriosus
R152 T667 T633 punct .,leads
R153 T669 T670 mark While,required
R154 T670 T674 advcl required,demonstrate
R155 T671 T670 nsubjpass ALK5,required
R156 T672 T670 auxpass is,required
R157 T673 T670 neg not,required
R158 T675 T670 prep for,required
R159 T676 T677 amod neural,cell
R160 T677 T679 compound cell,migration
R161 T678 T677 compound crest,cell
R162 T679 T675 pobj migration,for
R163 T680 T674 punct ", ",demonstrate
R164 T681 T682 poss our,results
R165 T682 T674 nsubj results,demonstrate
R166 T683 T684 mark that,plays
R167 T684 T674 ccomp plays,demonstrate
R168 T685 T684 nsubj it,plays
R169 T686 T687 det an,role
R170 T687 T684 dobj role,plays
R171 T688 T687 amod important,role
R172 T689 T684 prep in,plays
R173 T690 T691 det the,survival
R174 T691 T689 pobj survival,in
R175 T692 T691 prep of,survival
R176 T693 T694 amod post-migratory,cells
R177 T694 T692 pobj cells,of
R178 T695 T696 amod cardiac,crest
R179 T696 T694 compound crest,cells
R180 T697 T696 amod neural,crest
R181 T698 T674 punct .,demonstrate
R182 T702 T703 poss Our,results
R183 T703 T704 nsubj results,demonstrate
R184 T705 T706 mark that,plays
R185 T706 T704 ccomp plays,demonstrate
R186 T707 T708 npadvmod ALK5,mediated
R187 T708 T710 amod mediated,signaling
R188 T709 T708 punct -,mediated
R189 T710 T706 nsubj signaling,plays
R190 T711 T710 prep in,signaling
R191 T712 T713 amod neural,cells
R192 T713 T711 pobj cells,in
R193 T714 T713 compound crest,cells
R194 T715 T716 det an,role
R195 T716 T706 dobj role,plays
R196 T717 T716 amod essential,role
R197 T718 T719 npadvmod cell,autonomous
R198 T719 T716 amod autonomous,role
R199 T720 T719 punct -,autonomous
R200 T721 T716 prep in,role
R201 T722 T723 det the,development
R202 T723 T721 pobj development,in
R203 T724 T725 amod pharyngeal,tract
R204 T725 T723 compound tract,development
R205 T726 T724 cc and,pharyngeal
R206 T727 T724 conj cardiac,pharyngeal
R207 T728 T725 compound outflow,tract
R208 T729 T704 punct .,demonstrate
R34 T538 T539 amod Congenital,diseases
R35 T539 T541 nsubj diseases,are
R36 T540 T539 amod cardiovascular,diseases
R37 T542 T543 det the,form
R38 T543 T541 attr form,are
R39 T544 T545 advmod most,common
R40 T545 T543 amod common,form
R41 T546 T543 prep of,form
R42 T547 T548 compound birth,defects
R43 T548 T546 pobj defects,of
R44 T549 T543 prep in,form
R45 T550 T549 pobj humans,in
R46 T551 T541 punct .,are
R47 T553 T554 det A,portion
R48 T554 T556 nsubjpass portion,associated
R49 T555 T554 amod substantial,portion
R50 T557 T554 prep of,portion
R51 T558 T559 det these,defects
R52 T559 T557 pobj defects,of
R53 T560 T556 aux has,associated
R54 T561 T556 auxpass been,associated
R55 T562 T556 prep with,associated
R56 T563 T564 amod inappropriate,induction
R57 T564 T562 pobj induction,with
R58 T565 T564 punct ", ",induction
R59 T566 T564 conj migration,induction
R60 T567 T566 punct ", ",migration
R61 T568 T566 conj differentiation,migration
R62 T569 T568 cc and,differentiation
R63 T570 T568 conj patterning,differentiation
R64 T571 T564 prep of,induction
R65 T572 T573 amod pluripotent,cells
R66 T573 T571 pobj cells,of
R67 T574 T575 amod cardiac,crest
R68 T575 T573 compound crest,cells
R69 T576 T575 amod neural,crest
R70 T577 T573 compound stem,cells
R71 T578 T556 punct .,associated
R72 T580 T581 mark While,implicated
R73 T581 T591 advcl implicated,understood
R74 T582 T583 compound TGF,β
R75 T583 T585 compound β,superfamily
R76 T584 T583 punct -,β
R77 T585 T587 compound superfamily,signaling
R78 T586 T585 punct -,superfamily
R79 T587 T581 nsubjpass signaling,implicated
R80 T588 T581 aux has,implicated
R81 T589 T581 auxpass been,implicated
R82 T590 T581 advmod strongly,implicated
R83 T592 T581 prep in,implicated
R84 T593 T594 amod neural,cell
R85 T594 T596 compound cell,development
R86 T595 T594 compound crest,cell
R87 T596 T592 pobj development,in
R88 T597 T591 punct ", ",understood
R89 T598 T599 det the,mechanisms
R90 T599 T591 nsubjpass mechanisms,understood
R91 T600 T599 amod detailed,mechanisms
R92 T601 T599 amod molecular,mechanisms
R93 T602 T599 compound signaling,mechanisms
R94 T603 T604 advmod in,vivo
R95 T604 T599 advmod vivo,mechanisms
R96 T605 T591 auxpass are,understood
R97 T606 T591 advmod still,understood
R98 T607 T591 advmod poorly,understood
R99 T608 T591 punct .,understood