Id |
Subject |
Object |
Predicate |
Lexical cue |
T1039 |
13-16 |
DT |
denotes |
The |
T1041 |
17-23 |
NN |
denotes |
RanBP2 |
T1042 |
23-24 |
HYPH |
denotes |
/ |
T1040 |
24-30 |
NN |
denotes |
Nup358 |
T1043 |
31-33 |
VBZ |
denotes |
is |
T1044 |
34-35 |
DT |
denotes |
a |
T1046 |
36-42 |
JJ |
denotes |
unique |
T1047 |
43-53 |
NN |
denotes |
vertebrate |
T1048 |
54-57 |
CC |
denotes |
and |
T1049 |
58-63 |
JJ |
denotes |
large |
T1050 |
64-72 |
NN |
denotes |
scaffold |
T1045 |
73-80 |
NN |
denotes |
protein |
T1051 |
81-90 |
VBN |
denotes |
comprised |
T1052 |
91-93 |
IN |
denotes |
of |
T1053 |
94-102 |
JJ |
denotes |
multiple |
T1055 |
103-113 |
JJ |
denotes |
structural |
T1056 |
114-117 |
CC |
denotes |
and |
T1057 |
118-128 |
JJ |
denotes |
functional |
T1054 |
129-136 |
NNS |
denotes |
domains |
T1058 |
137-138 |
-LRB- |
denotes |
[ |
T1059 |
138-139 |
CD |
denotes |
1 |
T1060 |
139-140 |
SYM |
denotes |
– |
T1061 |
140-141 |
CD |
denotes |
4 |
T1062 |
141-142 |
-RRB- |
denotes |
] |
T1063 |
142-143 |
. |
denotes |
. |
T1064 |
143-478 |
sentence |
denotes |
Several roles of RanBP2 have emerged that implicate RanBP2 in nucleocytoplasmic trafficking [3,5], protein biogenesis [6,7], the formation of the mitotic spindle, assembly of the nuclear envelope [8], and the integration of the nuclear envelope breakdown with kinetochore formation and maturation during early mitotic progression [9]. |
T1065 |
144-151 |
JJ |
denotes |
Several |
T1066 |
152-157 |
NNS |
denotes |
roles |
T1068 |
158-160 |
IN |
denotes |
of |
T1069 |
161-167 |
NN |
denotes |
RanBP2 |
T1070 |
168-172 |
VBP |
denotes |
have |
T1067 |
173-180 |
VBN |
denotes |
emerged |
T1071 |
181-185 |
WDT |
denotes |
that |
T1072 |
186-195 |
VBP |
denotes |
implicate |
T1073 |
196-202 |
NN |
denotes |
RanBP2 |
T1074 |
203-205 |
IN |
denotes |
in |
T1075 |
206-223 |
JJ |
denotes |
nucleocytoplasmic |
T1076 |
224-235 |
NN |
denotes |
trafficking |
T1077 |
236-237 |
-LRB- |
denotes |
[ |
T1079 |
237-238 |
CD |
denotes |
3 |
T1080 |
238-239 |
, |
denotes |
, |
T1078 |
239-240 |
CD |
denotes |
5 |
T1081 |
240-241 |
-RRB- |
denotes |
] |
T1082 |
241-243 |
, |
denotes |
, |
T1083 |
243-250 |
NN |
denotes |
protein |
T1084 |
251-261 |
NN |
denotes |
biogenesis |
T1085 |
262-263 |
-LRB- |
denotes |
[ |
T1087 |
263-264 |
CD |
denotes |
6 |
T1088 |
264-265 |
, |
denotes |
, |
T1086 |
265-266 |
CD |
denotes |
7 |
T1089 |
266-267 |
-RRB- |
denotes |
] |
T1090 |
267-269 |
, |
denotes |
, |
T1091 |
269-272 |
DT |
denotes |
the |
T1092 |
273-282 |
NN |
denotes |
formation |
T1093 |
283-285 |
IN |
denotes |
of |
T1094 |
286-289 |
DT |
denotes |
the |
T1096 |
290-297 |
JJ |
denotes |
mitotic |
T1095 |
298-305 |
NN |
denotes |
spindle |
T1097 |
305-307 |
, |
denotes |
, |
T1098 |
307-315 |
NN |
denotes |
assembly |
T1099 |
316-318 |
IN |
denotes |
of |
T1100 |
319-322 |
DT |
denotes |
the |
T1102 |
323-330 |
JJ |
denotes |
nuclear |
T1101 |
331-339 |
NN |
denotes |
envelope |
T1103 |
340-341 |
-LRB- |
denotes |
[ |
T1104 |
341-342 |
CD |
denotes |
8 |
T1105 |
342-343 |
-RRB- |
denotes |
] |
T1106 |
343-345 |
, |
denotes |
, |
T1107 |
345-348 |
CC |
denotes |
and |
T1108 |
349-352 |
DT |
denotes |
the |
T1109 |
353-364 |
NN |
denotes |
integration |
T1110 |
365-367 |
IN |
denotes |
of |
T1111 |
368-371 |
DT |
denotes |
the |
T1113 |
372-379 |
JJ |
denotes |
nuclear |
T1114 |
380-388 |
NN |
denotes |
envelope |
T1112 |
389-398 |
NN |
denotes |
breakdown |
T1115 |
399-403 |
IN |
denotes |
with |
T1116 |
404-415 |
NN |
denotes |
kinetochore |
T1117 |
416-425 |
NN |
denotes |
formation |
T1118 |
426-429 |
CC |
denotes |
and |
T1119 |
430-440 |
NN |
denotes |
maturation |
T1120 |
441-447 |
IN |
denotes |
during |
T1121 |
448-453 |
JJ |
denotes |
early |
T1123 |
454-461 |
JJ |
denotes |
mitotic |
T1122 |
462-473 |
NN |
denotes |
progression |
T1124 |
474-475 |
-LRB- |
denotes |
[ |
T1125 |
475-476 |
CD |
denotes |
9 |
T1126 |
476-477 |
-RRB- |
denotes |
] |
T1127 |
477-478 |
. |
denotes |
. |
T1128 |
478-662 |
sentence |
denotes |
The specific interaction of RanBP2 with a diverse set of partners likely reflects a pleiotropic role of RanBP2 in cell function, possibly through the integration of multiple pathways. |
T1129 |
479-482 |
DT |
denotes |
The |
T1131 |
483-491 |
JJ |
denotes |
specific |
T1130 |
492-503 |
NN |
denotes |
interaction |
T1133 |
504-506 |
IN |
denotes |
of |
T1134 |
507-513 |
NN |
denotes |
RanBP2 |
T1135 |
514-518 |
IN |
denotes |
with |
T1136 |
519-520 |
DT |
denotes |
a |
T1138 |
521-528 |
JJ |
denotes |
diverse |
T1137 |
529-532 |
NN |
denotes |
set |
T1139 |
533-535 |
IN |
denotes |
of |
T1140 |
536-544 |
NNS |
denotes |
partners |
T1141 |
545-551 |
RB |
denotes |
likely |
T1132 |
552-560 |
VBZ |
denotes |
reflects |
T1142 |
561-562 |
DT |
denotes |
a |
T1144 |
563-574 |
JJ |
denotes |
pleiotropic |
T1143 |
575-579 |
NN |
denotes |
role |
T1145 |
580-582 |
IN |
denotes |
of |
T1146 |
583-589 |
NN |
denotes |
RanBP2 |
T1147 |
590-592 |
IN |
denotes |
in |
T1148 |
593-597 |
NN |
denotes |
cell |
T1149 |
598-606 |
NN |
denotes |
function |
T1150 |
606-608 |
, |
denotes |
, |
T1151 |
608-616 |
RB |
denotes |
possibly |
T1152 |
617-624 |
IN |
denotes |
through |
T1153 |
625-628 |
DT |
denotes |
the |
T1154 |
629-640 |
NN |
denotes |
integration |
T1155 |
641-643 |
IN |
denotes |
of |
T1156 |
644-652 |
JJ |
denotes |
multiple |
T1157 |
653-661 |
NNS |
denotes |
pathways |
T1158 |
661-662 |
. |
denotes |
. |
T1159 |
662-806 |
sentence |
denotes |
On the other hand, the cell (tissue)-selective interaction of RanBP2 with some of its partners may also impart cell-restricted roles to RanBP2. |
T1160 |
663-665 |
IN |
denotes |
On |
T1162 |
666-669 |
DT |
denotes |
the |
T1164 |
670-675 |
JJ |
denotes |
other |
T1163 |
676-680 |
NN |
denotes |
hand |
T1165 |
680-682 |
, |
denotes |
, |
T1166 |
682-685 |
DT |
denotes |
the |
T1168 |
686-690 |
NN |
denotes |
cell |
T1170 |
691-692 |
-LRB- |
denotes |
( |
T1171 |
692-698 |
NN |
denotes |
tissue |
T1172 |
698-699 |
-RRB- |
denotes |
) |
T1173 |
699-700 |
HYPH |
denotes |
- |
T1169 |
700-709 |
JJ |
denotes |
selective |
T1167 |
710-721 |
NN |
denotes |
interaction |
T1174 |
722-724 |
IN |
denotes |
of |
T1175 |
725-731 |
NN |
denotes |
RanBP2 |
T1176 |
732-736 |
IN |
denotes |
with |
T1177 |
737-741 |
DT |
denotes |
some |
T1178 |
742-744 |
IN |
denotes |
of |
T1179 |
745-748 |
PRP$ |
denotes |
its |
T1180 |
749-757 |
NNS |
denotes |
partners |
T1181 |
758-761 |
MD |
denotes |
may |
T1182 |
762-766 |
RB |
denotes |
also |
T1161 |
767-773 |
VB |
denotes |
impart |
T1183 |
774-778 |
NN |
denotes |
cell |
T1185 |
778-779 |
HYPH |
denotes |
- |
T1184 |
779-789 |
JJ |
denotes |
restricted |
T1186 |
790-795 |
NNS |
denotes |
roles |
T1187 |
796-798 |
IN |
denotes |
to |
T1188 |
799-805 |
NN |
denotes |
RanBP2 |
T1189 |
805-806 |
. |
denotes |
. |
T1190 |
806-1072 |
sentence |
denotes |
For example, the Ran-binding domains RBDn=1-4 of RanBP2 associate with the nuclear import co-receptor, importin-β [10,11], and antibodies against RanBP2 inhibit the nuclear import pathway in HeLa cells [3]; but such a role seems dispensable in Xenopus oocytes [12]. |
T1191 |
807-810 |
IN |
denotes |
For |
T1193 |
811-818 |
NN |
denotes |
example |
T1194 |
818-820 |
, |
denotes |
, |
T1195 |
820-823 |
DT |
denotes |
the |
T1197 |
824-827 |
NN |
denotes |
Ran |
T1199 |
827-828 |
HYPH |
denotes |
- |
T1198 |
828-835 |
VBG |
denotes |
binding |
T1196 |
836-843 |
NNS |
denotes |
domains |
T1200 |
844-848 |
NN |
denotes |
RBDn |
T1202 |
848-849 |
SYM |
denotes |
= |
T1201 |
849-850 |
CD |
denotes |
1 |
T1203 |
850-851 |
SYM |
denotes |
- |
T1204 |
851-852 |
CD |
denotes |
4 |
T1205 |
853-855 |
IN |
denotes |
of |
T1206 |
856-862 |
NN |
denotes |
RanBP2 |
T1192 |
863-872 |
VBP |
denotes |
associate |
T1207 |
873-877 |
IN |
denotes |
with |
T1208 |
878-881 |
DT |
denotes |
the |
T1210 |
882-889 |
JJ |
denotes |
nuclear |
T1211 |
890-896 |
NN |
denotes |
import |
T1209 |
897-908 |
NN |
denotes |
co-receptor |
T1212 |
908-910 |
, |
denotes |
, |
T1213 |
910-918 |
NN |
denotes |
importin |
T1215 |
918-919 |
HYPH |
denotes |
- |
T1214 |
919-920 |
NN |
denotes |
β |
T1216 |
921-922 |
-LRB- |
denotes |
[ |
T1218 |
922-924 |
CD |
denotes |
10 |
T1219 |
924-925 |
, |
denotes |
, |
T1217 |
925-927 |
CD |
denotes |
11 |
T1220 |
927-928 |
-RRB- |
denotes |
] |
T1221 |
928-930 |
, |
denotes |
, |
T1222 |
930-933 |
CC |
denotes |
and |
T1223 |
934-944 |
NNS |
denotes |
antibodies |
T1225 |
945-952 |
IN |
denotes |
against |
T1226 |
953-959 |
NN |
denotes |
RanBP2 |
T1224 |
960-967 |
VBP |
denotes |
inhibit |
T1227 |
968-971 |
DT |
denotes |
the |
T1229 |
972-979 |
JJ |
denotes |
nuclear |
T1230 |
980-986 |
NN |
denotes |
import |
T1228 |
987-994 |
NN |
denotes |
pathway |
T1231 |
995-997 |
IN |
denotes |
in |
T1232 |
998-1002 |
NN |
denotes |
HeLa |
T1233 |
1003-1008 |
NNS |
denotes |
cells |
T1234 |
1009-1010 |
-LRB- |
denotes |
[ |
T1235 |
1010-1011 |
CD |
denotes |
3 |
T1236 |
1011-1012 |
-RRB- |
denotes |
] |
T1237 |
1012-1013 |
: |
denotes |
; |
T1238 |
1014-1017 |
CC |
denotes |
but |
T1239 |
1018-1022 |
PDT |
denotes |
such |
T1241 |
1023-1024 |
DT |
denotes |
a |
T1240 |
1025-1029 |
NN |
denotes |
role |
T1242 |
1030-1035 |
VBZ |
denotes |
seems |
T1243 |
1036-1047 |
JJ |
denotes |
dispensable |
T1244 |
1048-1050 |
IN |
denotes |
in |
T1245 |
1051-1058 |
NN |
denotes |
Xenopus |
T1246 |
1059-1066 |
NNS |
denotes |
oocytes |
T1247 |
1067-1068 |
-LRB- |
denotes |
[ |
T1248 |
1068-1070 |
CD |
denotes |
12 |
T1249 |
1070-1071 |
-RRB- |
denotes |
] |
T1250 |
1071-1072 |
. |
denotes |
. |
T1251 |
1072-1516 |
sentence |
denotes |
In addition, the combination of the C-terminal domains, RBD4 and CY (of RanBP2), associates with a subset of G protein-coupled receptors, the red/green opsin, expressed in photosensory neurons and enhances opsin functional production [6,7], while the interaction of the KBD of RanBP2 with a subset of the conventional microtubule-based motor proteins, the kinesins, KIF5B and KIF5C, occurs selectively in the central nervous system (CNS) [13]. |
T1252 |
1073-1075 |
IN |
denotes |
In |
T1254 |
1076-1084 |
NN |
denotes |
addition |
T1255 |
1084-1086 |
, |
denotes |
, |
T1256 |
1086-1089 |
DT |
denotes |
the |
T1257 |
1090-1101 |
NN |
denotes |
combination |
T1258 |
1102-1104 |
IN |
denotes |
of |
T1259 |
1105-1108 |
DT |
denotes |
the |
T1261 |
1109-1110 |
NN |
denotes |
C |
T1263 |
1110-1111 |
HYPH |
denotes |
- |
T1262 |
1111-1119 |
JJ |
denotes |
terminal |
T1260 |
1120-1127 |
NNS |
denotes |
domains |
T1264 |
1127-1129 |
, |
denotes |
, |
T1265 |
1129-1133 |
NN |
denotes |
RBD4 |
T1266 |
1134-1137 |
CC |
denotes |
and |
T1267 |
1138-1140 |
NN |
denotes |
CY |
T1268 |
1141-1142 |
-LRB- |
denotes |
( |
T1269 |
1142-1144 |
IN |
denotes |
of |
T1270 |
1145-1151 |
NN |
denotes |
RanBP2 |
T1271 |
1151-1152 |
-RRB- |
denotes |
) |
T1272 |
1152-1154 |
, |
denotes |
, |
T1253 |
1154-1164 |
VBZ |
denotes |
associates |
T1273 |
1165-1169 |
IN |
denotes |
with |
T1274 |
1170-1171 |
DT |
denotes |
a |
T1275 |
1172-1178 |
NN |
denotes |
subset |
T1276 |
1179-1181 |
IN |
denotes |
of |
T1277 |
1182-1183 |
NN |
denotes |
G |
T1278 |
1184-1191 |
NN |
denotes |
protein |
T1280 |
1191-1192 |
HYPH |
denotes |
- |
T1279 |
1192-1199 |
VBN |
denotes |
coupled |
T1281 |
1200-1209 |
NNS |
denotes |
receptors |
T1282 |
1209-1211 |
, |
denotes |
, |
T1283 |
1211-1214 |
DT |
denotes |
the |
T1285 |
1215-1218 |
JJ |
denotes |
red |
T1287 |
1218-1219 |
HYPH |
denotes |
/ |
T1286 |
1219-1224 |
JJ |
denotes |
green |
T1284 |
1225-1230 |
NN |
denotes |
opsin |
T1288 |
1230-1232 |
, |
denotes |
, |
T1289 |
1232-1241 |
VBN |
denotes |
expressed |
T1290 |
1242-1244 |
IN |
denotes |
in |
T1291 |
1245-1257 |
JJ |
denotes |
photosensory |
T1292 |
1258-1265 |
NNS |
denotes |
neurons |
T1293 |
1266-1269 |
CC |
denotes |
and |
T1294 |
1270-1278 |
VBZ |
denotes |
enhances |
T1295 |
1279-1284 |
NN |
denotes |
opsin |
T1297 |
1285-1295 |
JJ |
denotes |
functional |
T1296 |
1296-1306 |
NN |
denotes |
production |
T1298 |
1307-1308 |
-LRB- |
denotes |
[ |
T1300 |
1308-1309 |
CD |
denotes |
6 |
T1301 |
1309-1310 |
, |
denotes |
, |
T1299 |
1310-1311 |
CD |
denotes |
7 |
T1302 |
1311-1312 |
-RRB- |
denotes |
] |
T1303 |
1312-1314 |
, |
denotes |
, |
T1304 |
1314-1319 |
IN |
denotes |
while |
T1306 |
1320-1323 |
DT |
denotes |
the |
T1307 |
1324-1335 |
NN |
denotes |
interaction |
T1308 |
1336-1338 |
IN |
denotes |
of |
T1309 |
1339-1342 |
DT |
denotes |
the |
T1310 |
1343-1346 |
NN |
denotes |
KBD |
T1311 |
1347-1349 |
IN |
denotes |
of |
T1312 |
1350-1356 |
NN |
denotes |
RanBP2 |
T1313 |
1357-1361 |
IN |
denotes |
with |
T1314 |
1362-1363 |
DT |
denotes |
a |
T1315 |
1364-1370 |
NN |
denotes |
subset |
T1316 |
1371-1373 |
IN |
denotes |
of |
T1317 |
1374-1377 |
DT |
denotes |
the |
T1319 |
1378-1390 |
JJ |
denotes |
conventional |
T1320 |
1391-1402 |
NN |
denotes |
microtubule |
T1322 |
1402-1403 |
HYPH |
denotes |
- |
T1321 |
1403-1408 |
VBN |
denotes |
based |
T1323 |
1409-1414 |
NN |
denotes |
motor |
T1318 |
1415-1423 |
NN |
denotes |
proteins |
T1324 |
1423-1425 |
, |
denotes |
, |
T1325 |
1425-1428 |
DT |
denotes |
the |
T1326 |
1429-1437 |
NNS |
denotes |
kinesins |
T1327 |
1437-1439 |
, |
denotes |
, |
T1328 |
1439-1444 |
NN |
denotes |
KIF5B |
T1329 |
1445-1448 |
CC |
denotes |
and |
T1330 |
1449-1454 |
NN |
denotes |
KIF5C |
T1331 |
1454-1456 |
, |
denotes |
, |
T1305 |
1456-1462 |
VBZ |
denotes |
occurs |
T1332 |
1463-1474 |
RB |
denotes |
selectively |
T1333 |
1475-1477 |
IN |
denotes |
in |
T1334 |
1478-1481 |
DT |
denotes |
the |
T1336 |
1482-1489 |
JJ |
denotes |
central |
T1337 |
1490-1497 |
JJ |
denotes |
nervous |
T1335 |
1498-1504 |
NN |
denotes |
system |
T1338 |
1505-1506 |
-LRB- |
denotes |
( |
T1339 |
1506-1509 |
NN |
denotes |
CNS |
T1340 |
1509-1510 |
-RRB- |
denotes |
) |
T1341 |
1511-1512 |
-LRB- |
denotes |
[ |
T1342 |
1512-1514 |
CD |
denotes |
13 |
T1343 |
1514-1515 |
-RRB- |
denotes |
] |
T1344 |
1515-1516 |
. |
denotes |
. |
T1345 |
1516-1692 |
sentence |
denotes |
A diverse set of additional molecular partners, each associating specifically with a selective domain of RanBP2, are likely to impart and integrate additional roles to RanBP2. |
T1346 |
1517-1518 |
DT |
denotes |
A |
T1348 |
1519-1526 |
JJ |
denotes |
diverse |
T1347 |
1527-1530 |
NN |
denotes |
set |
T1350 |
1531-1533 |
IN |
denotes |
of |
T1351 |
1534-1544 |
JJ |
denotes |
additional |
T1353 |
1545-1554 |
JJ |
denotes |
molecular |
T1352 |
1555-1563 |
NNS |
denotes |
partners |
T1354 |
1563-1565 |
, |
denotes |
, |
T1355 |
1565-1569 |
RB |
denotes |
each |
T1356 |
1570-1581 |
VBG |
denotes |
associating |
T1357 |
1582-1594 |
RB |
denotes |
specifically |
T1358 |
1595-1599 |
IN |
denotes |
with |
T1359 |
1600-1601 |
DT |
denotes |
a |
T1361 |
1602-1611 |
JJ |
denotes |
selective |
T1360 |
1612-1618 |
NN |
denotes |
domain |
T1362 |
1619-1621 |
IN |
denotes |
of |
T1363 |
1622-1628 |
NN |
denotes |
RanBP2 |
T1364 |
1628-1630 |
, |
denotes |
, |
T1349 |
1630-1633 |
VBP |
denotes |
are |
T1365 |
1634-1640 |
JJ |
denotes |
likely |
T1366 |
1641-1643 |
TO |
denotes |
to |
T1367 |
1644-1650 |
VB |
denotes |
impart |
T1368 |
1651-1654 |
CC |
denotes |
and |
T1369 |
1655-1664 |
VB |
denotes |
integrate |
T1370 |
1665-1675 |
JJ |
denotes |
additional |
T1371 |
1676-1681 |
NNS |
denotes |
roles |
T1372 |
1682-1684 |
IN |
denotes |
to |
T1373 |
1685-1691 |
NN |
denotes |
RanBP2 |
T1374 |
1691-1692 |
. |
denotes |
. |
T1375 |
1692-2009 |
sentence |
denotes |
For example, the cyclophilin-like domain (CLD), the internal repeat (W1W2/IR), and zinc-finger rich (ZnF) domains of RanBP2 associate specifically with components of the 19S cap of the proteasome [14], the E2 SUMO-1-conjugating enzyme (Ubc9) [15], and the nuclear export receptor, CRM1/exportin-1 [16], respectively. |
T1376 |
1693-1696 |
IN |
denotes |
For |
T1378 |
1697-1704 |
NN |
denotes |
example |
T1379 |
1704-1706 |
, |
denotes |
, |
T1380 |
1706-1709 |
DT |
denotes |
the |
T1382 |
1710-1721 |
NN |
denotes |
cyclophilin |
T1384 |
1721-1722 |
HYPH |
denotes |
- |
T1383 |
1722-1726 |
JJ |
denotes |
like |
T1381 |
1727-1733 |
NN |
denotes |
domain |
T1385 |
1734-1735 |
-LRB- |
denotes |
( |
T1386 |
1735-1738 |
NN |
denotes |
CLD |
T1387 |
1738-1739 |
-RRB- |
denotes |
) |
T1388 |
1739-1741 |
, |
denotes |
, |
T1389 |
1741-1744 |
DT |
denotes |
the |
T1391 |
1745-1753 |
JJ |
denotes |
internal |
T1392 |
1754-1760 |
NN |
denotes |
repeat |
T1393 |
1761-1762 |
-LRB- |
denotes |
( |
T1395 |
1762-1766 |
NN |
denotes |
W1W2 |
T1396 |
1766-1767 |
HYPH |
denotes |
/ |
T1394 |
1767-1769 |
NN |
denotes |
IR |
T1397 |
1769-1770 |
-RRB- |
denotes |
) |
T1398 |
1770-1772 |
, |
denotes |
, |
T1399 |
1772-1775 |
CC |
denotes |
and |
T1400 |
1776-1780 |
NN |
denotes |
zinc |
T1402 |
1780-1781 |
HYPH |
denotes |
- |
T1401 |
1781-1787 |
NN |
denotes |
finger |
T1403 |
1788-1792 |
JJ |
denotes |
rich |
T1404 |
1793-1794 |
-LRB- |
denotes |
( |
T1405 |
1794-1797 |
NN |
denotes |
ZnF |
T1406 |
1797-1798 |
-RRB- |
denotes |
) |
T1390 |
1799-1806 |
NNS |
denotes |
domains |
T1407 |
1807-1809 |
IN |
denotes |
of |
T1408 |
1810-1816 |
NN |
denotes |
RanBP2 |
T1377 |
1817-1826 |
VBP |
denotes |
associate |
T1409 |
1827-1839 |
RB |
denotes |
specifically |
T1410 |
1840-1844 |
IN |
denotes |
with |
T1411 |
1845-1855 |
NNS |
denotes |
components |
T1412 |
1856-1858 |
IN |
denotes |
of |
T1413 |
1859-1862 |
DT |
denotes |
the |
T1415 |
1863-1866 |
NN |
denotes |
19S |
T1414 |
1867-1870 |
NN |
denotes |
cap |
T1416 |
1871-1873 |
IN |
denotes |
of |
T1417 |
1874-1877 |
DT |
denotes |
the |
T1418 |
1878-1888 |
NN |
denotes |
proteasome |
T1419 |
1889-1890 |
-LRB- |
denotes |
[ |
T1420 |
1890-1892 |
CD |
denotes |
14 |
T1421 |
1892-1893 |
-RRB- |
denotes |
] |
T1422 |
1893-1895 |
, |
denotes |
, |
T1423 |
1895-1898 |
DT |
denotes |
the |
T1425 |
1899-1901 |
NN |
denotes |
E2 |
T1426 |
1902-1906 |
NN |
denotes |
SUMO |
T1428 |
1906-1907 |
HYPH |
denotes |
- |
T1429 |
1907-1908 |
CD |
denotes |
1 |
T1430 |
1908-1909 |
HYPH |
denotes |
- |
T1427 |
1909-1920 |
VBG |
denotes |
conjugating |
T1424 |
1921-1927 |
NN |
denotes |
enzyme |
T1431 |
1928-1929 |
-LRB- |
denotes |
( |
T1432 |
1929-1933 |
NN |
denotes |
Ubc9 |
T1433 |
1933-1934 |
-RRB- |
denotes |
) |
T1434 |
1935-1936 |
-LRB- |
denotes |
[ |
T1435 |
1936-1938 |
CD |
denotes |
15 |
T1436 |
1938-1939 |
-RRB- |
denotes |
] |
T1437 |
1939-1941 |
, |
denotes |
, |
T1438 |
1941-1944 |
CC |
denotes |
and |
T1439 |
1945-1948 |
DT |
denotes |
the |
T1441 |
1949-1956 |
JJ |
denotes |
nuclear |
T1442 |
1957-1963 |
NN |
denotes |
export |
T1440 |
1964-1972 |
NN |
denotes |
receptor |
T1443 |
1972-1974 |
, |
denotes |
, |
T1444 |
1974-1978 |
NN |
denotes |
CRM1 |
T1446 |
1978-1979 |
HYPH |
denotes |
/ |
T1445 |
1979-1987 |
NN |
denotes |
exportin |
T1447 |
1987-1988 |
HYPH |
denotes |
- |
T1448 |
1988-1989 |
CD |
denotes |
1 |
T1449 |
1990-1991 |
-LRB- |
denotes |
[ |
T1450 |
1991-1993 |
CD |
denotes |
16 |
T1451 |
1993-1994 |
-RRB- |
denotes |
] |
T1452 |
1994-1996 |
, |
denotes |
, |
T1453 |
1996-2008 |
RB |
denotes |
respectively |
T1454 |
2008-2009 |
. |
denotes |
. |
T1455 |
2009-2291 |
sentence |
denotes |
RanBP2 itself was also found to exhibit SUMO1 E3 ligase activity [17], supporting a direct link between RanBP2-mediated SUMO-1 substrate modification and relocation of SUMO-1 modified cytosolic substrates (e.g., RanGAP) to the cytosolic face of the nuclear pore complex (NPC) [18]. |
T1456 |
2010-2016 |
NN |
denotes |
RanBP2 |
T1458 |
2017-2023 |
PRP |
denotes |
itself |
T1459 |
2024-2027 |
VBD |
denotes |
was |
T1460 |
2028-2032 |
RB |
denotes |
also |
T1457 |
2033-2038 |
VBN |
denotes |
found |
T1461 |
2039-2041 |
TO |
denotes |
to |
T1462 |
2042-2049 |
VB |
denotes |
exhibit |
T1463 |
2050-2055 |
NN |
denotes |
SUMO1 |
T1465 |
2056-2058 |
NN |
denotes |
E3 |
T1464 |
2059-2065 |
NN |
denotes |
ligase |
T1466 |
2066-2074 |
NN |
denotes |
activity |
T1467 |
2075-2076 |
-LRB- |
denotes |
[ |
T1468 |
2076-2078 |
CD |
denotes |
17 |
T1469 |
2078-2079 |
-RRB- |
denotes |
] |
T1470 |
2079-2081 |
, |
denotes |
, |
T1471 |
2081-2091 |
VBG |
denotes |
supporting |
T1472 |
2092-2093 |
DT |
denotes |
a |
T1474 |
2094-2100 |
JJ |
denotes |
direct |
T1473 |
2101-2105 |
NN |
denotes |
link |
T1475 |
2106-2113 |
IN |
denotes |
between |
T1476 |
2114-2120 |
NN |
denotes |
RanBP2 |
T1478 |
2120-2121 |
HYPH |
denotes |
- |
T1477 |
2121-2129 |
JJ |
denotes |
mediated |
T1480 |
2130-2134 |
NN |
denotes |
SUMO |
T1482 |
2134-2135 |
HYPH |
denotes |
- |
T1483 |
2135-2136 |
CD |
denotes |
1 |
T1481 |
2137-2146 |
NN |
denotes |
substrate |
T1479 |
2147-2159 |
NN |
denotes |
modification |
T1484 |
2160-2163 |
CC |
denotes |
and |
T1485 |
2164-2174 |
NN |
denotes |
relocation |
T1486 |
2175-2177 |
IN |
denotes |
of |
T1487 |
2178-2182 |
NN |
denotes |
SUMO |
T1489 |
2182-2183 |
HYPH |
denotes |
- |
T1490 |
2183-2184 |
CD |
denotes |
1 |
T1488 |
2185-2193 |
VBN |
denotes |
modified |
T1492 |
2194-2203 |
JJ |
denotes |
cytosolic |
T1491 |
2204-2214 |
NNS |
denotes |
substrates |
T1493 |
2215-2216 |
-LRB- |
denotes |
( |
T1494 |
2216-2220 |
FW |
denotes |
e.g. |
T1496 |
2220-2222 |
, |
denotes |
, |
T1495 |
2222-2228 |
NN |
denotes |
RanGAP |
T1497 |
2228-2229 |
-RRB- |
denotes |
) |
T1498 |
2230-2232 |
IN |
denotes |
to |
T1499 |
2233-2236 |
DT |
denotes |
the |
T1501 |
2237-2246 |
JJ |
denotes |
cytosolic |
T1500 |
2247-2251 |
NN |
denotes |
face |
T1502 |
2252-2254 |
IN |
denotes |
of |
T1503 |
2255-2258 |
DT |
denotes |
the |
T1505 |
2259-2266 |
JJ |
denotes |
nuclear |
T1506 |
2267-2271 |
NN |
denotes |
pore |
T1504 |
2272-2279 |
NN |
denotes |
complex |
T1507 |
2280-2281 |
-LRB- |
denotes |
( |
T1508 |
2281-2284 |
NN |
denotes |
NPC |
T1509 |
2284-2285 |
-RRB- |
denotes |
) |
T1510 |
2286-2287 |
-LRB- |
denotes |
[ |
T1511 |
2287-2289 |
CD |
denotes |
18 |
T1512 |
2289-2290 |
-RRB- |
denotes |
] |
T1513 |
2290-2291 |
. |
denotes |
. |
T1514 |
2291-2598 |
sentence |
denotes |
Finally, RanBP2 was also found to localize prominently to the mitochondria-rich ellipsoid subcellular compartment of photosensory neurons [19] and to RanGTPase-restricted foci along cytoplasmic tracks [19], in addition to its localization at cytoplasmic fibrils emanating from nuclear pores [2,3,10,12,19]. |
T1515 |
2292-2299 |
RB |
denotes |
Finally |
T1517 |
2299-2301 |
, |
denotes |
, |
T1518 |
2301-2307 |
NN |
denotes |
RanBP2 |
T1519 |
2308-2311 |
VBD |
denotes |
was |
T1520 |
2312-2316 |
RB |
denotes |
also |
T1516 |
2317-2322 |
VBN |
denotes |
found |
T1521 |
2323-2325 |
TO |
denotes |
to |
T1522 |
2326-2334 |
VB |
denotes |
localize |
T1523 |
2335-2346 |
RB |
denotes |
prominently |
T1524 |
2347-2349 |
IN |
denotes |
to |
T1525 |
2350-2353 |
DT |
denotes |
the |
T1527 |
2354-2366 |
NNS |
denotes |
mitochondria |
T1529 |
2366-2367 |
HYPH |
denotes |
- |
T1528 |
2367-2371 |
JJ |
denotes |
rich |
T1530 |
2372-2381 |
JJ |
denotes |
ellipsoid |
T1531 |
2382-2393 |
JJ |
denotes |
subcellular |
T1526 |
2394-2405 |
NN |
denotes |
compartment |
T1532 |
2406-2408 |
IN |
denotes |
of |
T1533 |
2409-2421 |
JJ |
denotes |
photosensory |
T1534 |
2422-2429 |
NNS |
denotes |
neurons |
T1535 |
2430-2431 |
-LRB- |
denotes |
[ |
T1536 |
2431-2433 |
CD |
denotes |
19 |
T1537 |
2433-2434 |
-RRB- |
denotes |
] |
T1538 |
2435-2438 |
CC |
denotes |
and |
T1539 |
2439-2441 |
IN |
denotes |
to |
T1540 |
2442-2451 |
NN |
denotes |
RanGTPase |
T1542 |
2451-2452 |
HYPH |
denotes |
- |
T1541 |
2452-2462 |
VBN |
denotes |
restricted |
T1543 |
2463-2467 |
NNS |
denotes |
foci |
T1544 |
2468-2473 |
IN |
denotes |
along |
T1545 |
2474-2485 |
JJ |
denotes |
cytoplasmic |
T1546 |
2486-2492 |
NNS |
denotes |
tracks |
T1547 |
2493-2494 |
-LRB- |
denotes |
[ |
T1548 |
2494-2496 |
CD |
denotes |
19 |
T1549 |
2496-2497 |
-RRB- |
denotes |
] |
T1550 |
2497-2499 |
, |
denotes |
, |
T1551 |
2499-2501 |
IN |
denotes |
in |
T1552 |
2502-2510 |
NN |
denotes |
addition |
T1553 |
2511-2513 |
IN |
denotes |
to |
T1554 |
2514-2517 |
PRP$ |
denotes |
its |
T1555 |
2518-2530 |
NN |
denotes |
localization |
T1556 |
2531-2533 |
IN |
denotes |
at |
T1557 |
2534-2545 |
JJ |
denotes |
cytoplasmic |
T1558 |
2546-2553 |
NNS |
denotes |
fibrils |
T1559 |
2554-2563 |
VBG |
denotes |
emanating |
T1560 |
2564-2568 |
IN |
denotes |
from |
T1561 |
2569-2576 |
JJ |
denotes |
nuclear |
T1562 |
2577-2582 |
NNS |
denotes |
pores |
T1563 |
2583-2584 |
-LRB- |
denotes |
[ |
T1565 |
2584-2585 |
CD |
denotes |
2 |
T1566 |
2585-2586 |
, |
denotes |
, |
T1567 |
2586-2587 |
CD |
denotes |
3 |
T1568 |
2587-2588 |
, |
denotes |
, |
T1569 |
2588-2590 |
CD |
denotes |
10 |
T1570 |
2590-2591 |
, |
denotes |
, |
T1571 |
2591-2593 |
CD |
denotes |
12 |
T1572 |
2593-2594 |
, |
denotes |
, |
T1564 |
2594-2596 |
CD |
denotes |
19 |
T1573 |
2596-2597 |
-RRB- |
denotes |
] |
T1574 |
2597-2598 |
. |
denotes |
. |
T1575 |
2598-2726 |
sentence |
denotes |
Emerging evidence supports that the CNS-selective effects of RanBP2 may also underlie the pathogenesis of certain neuropathies. |
T1576 |
2599-2607 |
VBG |
denotes |
Emerging |
T1577 |
2608-2616 |
NN |
denotes |
evidence |
T1578 |
2617-2625 |
VBZ |
denotes |
supports |
T1579 |
2626-2630 |
IN |
denotes |
that |
T1581 |
2631-2634 |
DT |
denotes |
the |
T1583 |
2635-2638 |
NN |
denotes |
CNS |
T1585 |
2638-2639 |
HYPH |
denotes |
- |
T1584 |
2639-2648 |
JJ |
denotes |
selective |
T1582 |
2649-2656 |
NNS |
denotes |
effects |
T1586 |
2657-2659 |
IN |
denotes |
of |
T1587 |
2660-2666 |
NN |
denotes |
RanBP2 |
T1588 |
2667-2670 |
MD |
denotes |
may |
T1589 |
2671-2675 |
RB |
denotes |
also |
T1580 |
2676-2684 |
VB |
denotes |
underlie |
T1590 |
2685-2688 |
DT |
denotes |
the |
T1591 |
2689-2701 |
NN |
denotes |
pathogenesis |
T1592 |
2702-2704 |
IN |
denotes |
of |
T1593 |
2705-2712 |
JJ |
denotes |
certain |
T1594 |
2713-2725 |
NNS |
denotes |
neuropathies |
T1595 |
2725-2726 |
. |
denotes |
. |
T1596 |
2726-2822 |
sentence |
denotes |
Parkin is ubiquitously expressed and interacts with the Ubc9-interacting domain of RanBP2 [20]. |
T1597 |
2727-2733 |
NN |
denotes |
Parkin |
T1599 |
2734-2736 |
VBZ |
denotes |
is |
T1600 |
2737-2749 |
RB |
denotes |
ubiquitously |
T1598 |
2750-2759 |
VBN |
denotes |
expressed |
T1601 |
2760-2763 |
CC |
denotes |
and |
T1602 |
2764-2773 |
VBZ |
denotes |
interacts |
T1603 |
2774-2778 |
IN |
denotes |
with |
T1604 |
2779-2782 |
DT |
denotes |
the |
T1606 |
2783-2787 |
NN |
denotes |
Ubc9 |
T1608 |
2787-2788 |
HYPH |
denotes |
- |
T1607 |
2788-2799 |
VBG |
denotes |
interacting |
T1605 |
2800-2806 |
NN |
denotes |
domain |
T1609 |
2807-2809 |
IN |
denotes |
of |
T1610 |
2810-2816 |
NN |
denotes |
RanBP2 |
T1611 |
2817-2818 |
-LRB- |
denotes |
[ |
T1612 |
2818-2820 |
CD |
denotes |
20 |
T1613 |
2820-2821 |
-RRB- |
denotes |
] |
T1614 |
2821-2822 |
. |
denotes |
. |
T1615 |
2822-2994 |
sentence |
denotes |
This promotes the ubiquitination and degradation of RanBP2 [20], possibly via the interaction of the CLD domain of RanBP2 with the 19S cap subunits of the proteasome [14]. |
T1616 |
2823-2827 |
DT |
denotes |
This |
T1617 |
2828-2836 |
VBZ |
denotes |
promotes |
T1618 |
2837-2840 |
DT |
denotes |
the |
T1619 |
2841-2855 |
NN |
denotes |
ubiquitination |
T1620 |
2856-2859 |
CC |
denotes |
and |
T1621 |
2860-2871 |
NN |
denotes |
degradation |
T1622 |
2872-2874 |
IN |
denotes |
of |
T1623 |
2875-2881 |
NN |
denotes |
RanBP2 |
T1624 |
2882-2883 |
-LRB- |
denotes |
[ |
T1625 |
2883-2885 |
CD |
denotes |
20 |
T1626 |
2885-2886 |
-RRB- |
denotes |
] |
T1627 |
2886-2888 |
, |
denotes |
, |
T1628 |
2888-2896 |
RB |
denotes |
possibly |
T1629 |
2897-2900 |
IN |
denotes |
via |
T1630 |
2901-2904 |
DT |
denotes |
the |
T1631 |
2905-2916 |
NN |
denotes |
interaction |
T1632 |
2917-2919 |
IN |
denotes |
of |
T1633 |
2920-2923 |
DT |
denotes |
the |
T1635 |
2924-2927 |
NN |
denotes |
CLD |
T1634 |
2928-2934 |
NN |
denotes |
domain |
T1636 |
2935-2937 |
IN |
denotes |
of |
T1637 |
2938-2944 |
NN |
denotes |
RanBP2 |
T1638 |
2945-2949 |
IN |
denotes |
with |
T1639 |
2950-2953 |
DT |
denotes |
the |
T1641 |
2954-2957 |
NN |
denotes |
19S |
T1642 |
2958-2961 |
NN |
denotes |
cap |
T1640 |
2962-2970 |
NNS |
denotes |
subunits |
T1643 |
2971-2973 |
IN |
denotes |
of |
T1644 |
2974-2977 |
DT |
denotes |
the |
T1645 |
2978-2988 |
NN |
denotes |
proteasome |
T1646 |
2989-2990 |
-LRB- |
denotes |
[ |
T1647 |
2990-2992 |
CD |
denotes |
14 |
T1648 |
2992-2993 |
-RRB- |
denotes |
] |
T1649 |
2993-2994 |
. |
denotes |
. |
T1650 |
2994-3191 |
sentence |
denotes |
Interestingly, the small yeast Ran-binding protein 1 (RanBP1), Yrb1p, with strong homology to the Ran-binding domains of RanBP2, is also required for cell-cycle regulated protein degradation [21]. |
T1651 |
2995-3008 |
RB |
denotes |
Interestingly |
T1653 |
3008-3010 |
, |
denotes |
, |
T1654 |
3010-3013 |
DT |
denotes |
the |
T1656 |
3014-3019 |
JJ |
denotes |
small |
T1657 |
3020-3025 |
NN |
denotes |
yeast |
T1658 |
3026-3029 |
NN |
denotes |
Ran |
T1660 |
3029-3030 |
HYPH |
denotes |
- |
T1659 |
3030-3037 |
VBG |
denotes |
binding |
T1655 |
3038-3045 |
NN |
denotes |
protein |
T1661 |
3046-3047 |
CD |
denotes |
1 |
T1662 |
3048-3049 |
-LRB- |
denotes |
( |
T1663 |
3049-3055 |
NN |
denotes |
RanBP1 |
T1664 |
3055-3056 |
-RRB- |
denotes |
) |
T1665 |
3056-3058 |
, |
denotes |
, |
T1666 |
3058-3063 |
NN |
denotes |
Yrb1p |
T1667 |
3063-3065 |
, |
denotes |
, |
T1668 |
3065-3069 |
IN |
denotes |
with |
T1669 |
3070-3076 |
JJ |
denotes |
strong |
T1670 |
3077-3085 |
NN |
denotes |
homology |
T1671 |
3086-3088 |
IN |
denotes |
to |
T1672 |
3089-3092 |
DT |
denotes |
the |
T1674 |
3093-3096 |
NN |
denotes |
Ran |
T1676 |
3096-3097 |
HYPH |
denotes |
- |
T1675 |
3097-3104 |
VBG |
denotes |
binding |
T1673 |
3105-3112 |
NNS |
denotes |
domains |
T1677 |
3113-3115 |
IN |
denotes |
of |
T1678 |
3116-3122 |
NN |
denotes |
RanBP2 |
T1679 |
3122-3124 |
, |
denotes |
, |
T1680 |
3124-3126 |
VBZ |
denotes |
is |
T1681 |
3127-3131 |
RB |
denotes |
also |
T1652 |
3132-3140 |
VBN |
denotes |
required |
T1682 |
3141-3144 |
IN |
denotes |
for |
T1683 |
3145-3149 |
NN |
denotes |
cell |
T1685 |
3149-3150 |
HYPH |
denotes |
- |
T1684 |
3150-3155 |
NN |
denotes |
cycle |
T1686 |
3156-3165 |
VBN |
denotes |
regulated |
T1688 |
3166-3173 |
NN |
denotes |
protein |
T1687 |
3174-3185 |
NN |
denotes |
degradation |
T1689 |
3186-3187 |
-LRB- |
denotes |
[ |
T1690 |
3187-3189 |
CD |
denotes |
21 |
T1691 |
3189-3190 |
-RRB- |
denotes |
] |
T1692 |
3190-3191 |
. |
denotes |
. |
T1693 |
3191-3349 |
sentence |
denotes |
Parkin, like RanBP2 [17], has E3-ligase activity [22–24]; and loss-of-function of parkin leads to early onset autosomal recessive juvenile Parkinsonism [25]. |
T1694 |
3192-3198 |
NN |
denotes |
Parkin |
T1696 |
3198-3200 |
, |
denotes |
, |
T1697 |
3200-3204 |
IN |
denotes |
like |
T1698 |
3205-3211 |
NN |
denotes |
RanBP2 |
T1699 |
3212-3213 |
-LRB- |
denotes |
[ |
T1700 |
3213-3215 |
CD |
denotes |
17 |
T1701 |
3215-3216 |
-RRB- |
denotes |
] |
T1702 |
3216-3218 |
, |
denotes |
, |
T1695 |
3218-3221 |
VBZ |
denotes |
has |
T1703 |
3222-3224 |
NN |
denotes |
E3 |
T1705 |
3224-3225 |
HYPH |
denotes |
- |
T1704 |
3225-3231 |
NN |
denotes |
ligase |
T1706 |
3232-3240 |
NN |
denotes |
activity |
T1707 |
3241-3242 |
-LRB- |
denotes |
[ |
T1708 |
3242-3244 |
CD |
denotes |
22 |
T1709 |
3244-3245 |
SYM |
denotes |
– |
T1710 |
3245-3247 |
CD |
denotes |
24 |
T1711 |
3247-3248 |
-RRB- |
denotes |
] |
T1712 |
3248-3249 |
: |
denotes |
; |
T1713 |
3250-3253 |
CC |
denotes |
and |
T1714 |
3254-3258 |
NN |
denotes |
loss |
T1716 |
3258-3259 |
HYPH |
denotes |
- |
T1717 |
3259-3261 |
IN |
denotes |
of |
T1718 |
3261-3262 |
HYPH |
denotes |
- |
T1719 |
3262-3270 |
NN |
denotes |
function |
T1720 |
3271-3273 |
IN |
denotes |
of |
T1721 |
3274-3280 |
NN |
denotes |
parkin |
T1715 |
3281-3286 |
VBZ |
denotes |
leads |
T1722 |
3287-3289 |
IN |
denotes |
to |
T1723 |
3290-3295 |
JJ |
denotes |
early |
T1724 |
3296-3301 |
NN |
denotes |
onset |
T1726 |
3302-3311 |
JJ |
denotes |
autosomal |
T1727 |
3312-3321 |
JJ |
denotes |
recessive |
T1728 |
3322-3330 |
JJ |
denotes |
juvenile |
T1725 |
3331-3343 |
NN |
denotes |
Parkinsonism |
T1729 |
3344-3345 |
-LRB- |
denotes |
[ |
T1730 |
3345-3347 |
CD |
denotes |
25 |
T1731 |
3347-3348 |
-RRB- |
denotes |
] |
T1732 |
3348-3349 |
. |
denotes |
. |
T1733 |
3349-3769 |
sentence |
denotes |
While the dopaminergic neuronal-restricted effects of mutations in parkin are not understood [25], parkin−/− mice exhibit mitochondrial dysfunction and energy and growth deficits, and a fraction of parkin localizes to the cytoplasmic face of the mitochondria, where together with other partners is thought to promote the degradation of selective mitochondrial substrates and to exert a neuroprotective function [26–29]. |
T1734 |
3350-3355 |
IN |
denotes |
While |
T1736 |
3356-3359 |
DT |
denotes |
the |
T1738 |
3360-3372 |
JJ |
denotes |
dopaminergic |
T1739 |
3373-3381 |
JJ |
denotes |
neuronal |
T1741 |
3381-3382 |
HYPH |
denotes |
- |
T1740 |
3382-3392 |
VBN |
denotes |
restricted |
T1737 |
3393-3400 |
NNS |
denotes |
effects |
T1742 |
3401-3403 |
IN |
denotes |
of |
T1743 |
3404-3413 |
NNS |
denotes |
mutations |
T1744 |
3414-3416 |
IN |
denotes |
in |
T1745 |
3417-3423 |
NN |
denotes |
parkin |
T1735 |
3424-3427 |
VBP |
denotes |
are |
T1747 |
3428-3431 |
RB |
denotes |
not |
T1748 |
3432-3442 |
JJ |
denotes |
understood |
T1749 |
3443-3444 |
-LRB- |
denotes |
[ |
T1750 |
3444-3446 |
CD |
denotes |
25 |
T1751 |
3446-3447 |
-RRB- |
denotes |
] |
T1752 |
3447-3449 |
, |
denotes |
, |
T1753 |
3449-3455 |
NN |
denotes |
parkin |
T1755 |
3455-3456 |
SYM |
denotes |
− |
T1756 |
3456-3457 |
HYPH |
denotes |
/ |
T1757 |
3457-3458 |
SYM |
denotes |
− |
T1754 |
3459-3463 |
NNS |
denotes |
mice |
T1746 |
3464-3471 |
VBP |
denotes |
exhibit |
T1758 |
3472-3485 |
JJ |
denotes |
mitochondrial |
T1759 |
3486-3497 |
NN |
denotes |
dysfunction |
T1760 |
3498-3501 |
CC |
denotes |
and |
T1761 |
3502-3508 |
NN |
denotes |
energy |
T1763 |
3509-3512 |
CC |
denotes |
and |
T1764 |
3513-3519 |
NN |
denotes |
growth |
T1762 |
3520-3528 |
NNS |
denotes |
deficits |
T1765 |
3528-3530 |
, |
denotes |
, |
T1766 |
3530-3533 |
CC |
denotes |
and |
T1767 |
3534-3535 |
DT |
denotes |
a |
T1768 |
3536-3544 |
NN |
denotes |
fraction |
T1770 |
3545-3547 |
IN |
denotes |
of |
T1771 |
3548-3554 |
NN |
denotes |
parkin |
T1769 |
3555-3564 |
VBZ |
denotes |
localizes |
T1772 |
3565-3567 |
IN |
denotes |
to |
T1773 |
3568-3571 |
DT |
denotes |
the |
T1775 |
3572-3583 |
JJ |
denotes |
cytoplasmic |
T1774 |
3584-3588 |
NN |
denotes |
face |
T1776 |
3589-3591 |
IN |
denotes |
of |
T1777 |
3592-3595 |
DT |
denotes |
the |
T1778 |
3596-3608 |
NNS |
denotes |
mitochondria |
T1779 |
3608-3610 |
, |
denotes |
, |
T1780 |
3610-3615 |
WRB |
denotes |
where |
T1782 |
3616-3624 |
RB |
denotes |
together |
T1783 |
3625-3629 |
IN |
denotes |
with |
T1784 |
3630-3635 |
JJ |
denotes |
other |
T1785 |
3636-3644 |
NNS |
denotes |
partners |
T1786 |
3645-3647 |
VBZ |
denotes |
is |
T1781 |
3648-3655 |
VBN |
denotes |
thought |
T1787 |
3656-3658 |
TO |
denotes |
to |
T1788 |
3659-3666 |
VB |
denotes |
promote |
T1789 |
3667-3670 |
DT |
denotes |
the |
T1790 |
3671-3682 |
NN |
denotes |
degradation |
T1791 |
3683-3685 |
IN |
denotes |
of |
T1792 |
3686-3695 |
JJ |
denotes |
selective |
T1794 |
3696-3709 |
JJ |
denotes |
mitochondrial |
T1793 |
3710-3720 |
NNS |
denotes |
substrates |
T1795 |
3721-3724 |
CC |
denotes |
and |
T1796 |
3725-3727 |
TO |
denotes |
to |
T1797 |
3728-3733 |
VB |
denotes |
exert |
T1798 |
3734-3735 |
DT |
denotes |
a |
T1800 |
3736-3751 |
JJ |
denotes |
neuroprotective |
T1799 |
3752-3760 |
NN |
denotes |
function |
T1801 |
3761-3762 |
-LRB- |
denotes |
[ |
T1802 |
3762-3764 |
CD |
denotes |
26 |
T1803 |
3764-3765 |
SYM |
denotes |
– |
T1804 |
3765-3767 |
CD |
denotes |
29 |
T1805 |
3767-3768 |
-RRB- |
denotes |
] |
T1806 |
3768-3769 |
. |
denotes |
. |
T1807 |
3769-3907 |
sentence |
denotes |
These data suggest that deficits in RanBP2 and parkin may share (patho) physiological pathways and support a multifaceted role of RanBP2. |
T1808 |
3770-3775 |
DT |
denotes |
These |
T1809 |
3776-3780 |
NNS |
denotes |
data |
T1810 |
3781-3788 |
VBP |
denotes |
suggest |
T1811 |
3789-3793 |
IN |
denotes |
that |
T1813 |
3794-3802 |
NNS |
denotes |
deficits |
T1814 |
3803-3805 |
IN |
denotes |
in |
T1815 |
3806-3812 |
NN |
denotes |
RanBP2 |
T1816 |
3813-3816 |
CC |
denotes |
and |
T1817 |
3817-3823 |
NN |
denotes |
parkin |
T1818 |
3824-3827 |
MD |
denotes |
may |
T1812 |
3828-3833 |
VB |
denotes |
share |
T1819 |
3834-3835 |
-LRB- |
denotes |
( |
T1821 |
3835-3840 |
AFX |
denotes |
patho |
T1822 |
3840-3841 |
-RRB- |
denotes |
) |
T1820 |
3842-3855 |
JJ |
denotes |
physiological |
T1823 |
3856-3864 |
NNS |
denotes |
pathways |
T1824 |
3865-3868 |
CC |
denotes |
and |
T1825 |
3869-3876 |
VB |
denotes |
support |
T1826 |
3877-3878 |
DT |
denotes |
a |
T1828 |
3879-3891 |
JJ |
denotes |
multifaceted |
T1827 |
3892-3896 |
NN |
denotes |
role |
T1829 |
3897-3899 |
IN |
denotes |
of |
T1830 |
3900-3906 |
NN |
denotes |
RanBP2 |
T1831 |
3906-3907 |
. |
denotes |
. |
T1832 |
3907-3983 |
sentence |
denotes |
Yet clear functions of RanBP2 in animal and cell physiology remain elusive. |
T1833 |
3908-3911 |
RB |
denotes |
Yet |
T1835 |
3912-3917 |
JJ |
denotes |
clear |
T1836 |
3918-3927 |
NNS |
denotes |
functions |
T1837 |
3928-3930 |
IN |
denotes |
of |
T1838 |
3931-3937 |
NN |
denotes |
RanBP2 |
T1839 |
3938-3940 |
IN |
denotes |
in |
T1840 |
3941-3947 |
NN |
denotes |
animal |
T1842 |
3948-3951 |
CC |
denotes |
and |
T1843 |
3952-3956 |
NN |
denotes |
cell |
T1841 |
3957-3967 |
NN |
denotes |
physiology |
T1834 |
3968-3974 |
VBP |
denotes |
remain |
T1844 |
3975-3982 |
JJ |
denotes |
elusive |
T1845 |
3982-3983 |
. |
denotes |
. |
T1846 |
3983-4304 |
sentence |
denotes |
Here, we report on the identification and function of two novel partners of RanBP2, Cox11 and hexokinase type I (HKI), which interact with a large and orphan domain of RanBP2, the leucine-rich domain (LD); and on the outcome of partial loss-of-function of RanBP2 on HKI, animal physiology, and glucose/energy metabolism. |
T1847 |
3984-3988 |
RB |
denotes |
Here |
T1849 |
3988-3990 |
, |
denotes |
, |
T1850 |
3990-3992 |
PRP |
denotes |
we |
T1848 |
3993-3999 |
VBP |
denotes |
report |
T1851 |
4000-4002 |
IN |
denotes |
on |
T1852 |
4003-4006 |
DT |
denotes |
the |
T1853 |
4007-4021 |
NN |
denotes |
identification |
T1854 |
4022-4025 |
CC |
denotes |
and |
T1855 |
4026-4034 |
NN |
denotes |
function |
T1856 |
4035-4037 |
IN |
denotes |
of |
T1857 |
4038-4041 |
CD |
denotes |
two |
T1859 |
4042-4047 |
JJ |
denotes |
novel |
T1858 |
4048-4056 |
NNS |
denotes |
partners |
T1860 |
4057-4059 |
IN |
denotes |
of |
T1861 |
4060-4066 |
NN |
denotes |
RanBP2 |
T1862 |
4066-4068 |
, |
denotes |
, |
T1863 |
4068-4073 |
NN |
denotes |
Cox11 |
T1864 |
4074-4077 |
CC |
denotes |
and |
T1865 |
4078-4088 |
NN |
denotes |
hexokinase |
T1866 |
4089-4093 |
NN |
denotes |
type |
T1867 |
4094-4095 |
CD |
denotes |
I |
T1868 |
4096-4097 |
-LRB- |
denotes |
( |
T1869 |
4097-4100 |
NN |
denotes |
HKI |
T1870 |
4100-4101 |
-RRB- |
denotes |
) |
T1871 |
4101-4103 |
, |
denotes |
, |
T1872 |
4103-4108 |
WDT |
denotes |
which |
T1873 |
4109-4117 |
VBP |
denotes |
interact |
T1874 |
4118-4122 |
IN |
denotes |
with |
T1875 |
4123-4124 |
DT |
denotes |
a |
T1877 |
4125-4130 |
JJ |
denotes |
large |
T1878 |
4131-4134 |
CC |
denotes |
and |
T1879 |
4135-4141 |
NN |
denotes |
orphan |
T1876 |
4142-4148 |
NN |
denotes |
domain |
T1880 |
4149-4151 |
IN |
denotes |
of |
T1881 |
4152-4158 |
NN |
denotes |
RanBP2 |
T1882 |
4158-4160 |
, |
denotes |
, |
T1883 |
4160-4163 |
DT |
denotes |
the |
T1885 |
4164-4171 |
NN |
denotes |
leucine |
T1887 |
4171-4172 |
HYPH |
denotes |
- |
T1886 |
4172-4176 |
JJ |
denotes |
rich |
T1884 |
4177-4183 |
NN |
denotes |
domain |
T1888 |
4184-4185 |
-LRB- |
denotes |
( |
T1889 |
4185-4187 |
NN |
denotes |
LD |
T1890 |
4187-4188 |
-RRB- |
denotes |
) |
T1891 |
4188-4189 |
: |
denotes |
; |
T1892 |
4190-4193 |
CC |
denotes |
and |
T1893 |
4194-4196 |
IN |
denotes |
on |
T1894 |
4197-4200 |
DT |
denotes |
the |
T1895 |
4201-4208 |
NN |
denotes |
outcome |
T1896 |
4209-4211 |
IN |
denotes |
of |
T1897 |
4212-4219 |
JJ |
denotes |
partial |
T1898 |
4220-4224 |
NN |
denotes |
loss |
T1899 |
4224-4225 |
HYPH |
denotes |
- |
T1900 |
4225-4227 |
IN |
denotes |
of |
T1901 |
4227-4228 |
HYPH |
denotes |
- |
T1902 |
4228-4236 |
NN |
denotes |
function |
T1903 |
4237-4239 |
IN |
denotes |
of |
T1904 |
4240-4246 |
NN |
denotes |
RanBP2 |
T1905 |
4247-4249 |
IN |
denotes |
on |
T1906 |
4250-4253 |
NN |
denotes |
HKI |
T1907 |
4253-4255 |
, |
denotes |
, |
T1908 |
4255-4261 |
NN |
denotes |
animal |
T1909 |
4262-4272 |
NN |
denotes |
physiology |
T1910 |
4272-4274 |
, |
denotes |
, |
T1911 |
4274-4277 |
CC |
denotes |
and |
T1912 |
4278-4285 |
NN |
denotes |
glucose |
T1914 |
4285-4286 |
HYPH |
denotes |
/ |
T1913 |
4286-4292 |
NN |
denotes |
energy |
T1915 |
4293-4303 |
NN |
denotes |
metabolism |
T1916 |
4303-4304 |
. |
denotes |
. |
R1000 |
T1730 |
T1715 |
parataxis |
25,leads |
R1001 |
T1731 |
T1730 |
punct |
],25 |
R1002 |
T1732 |
T1715 |
punct |
.,leads |
R1003 |
T1734 |
T1735 |
mark |
While,are |
R1004 |
T1735 |
T1746 |
advcl |
are,exhibit |
R1005 |
T1736 |
T1737 |
det |
the,effects |
R1006 |
T1737 |
T1735 |
nsubj |
effects,are |
R1007 |
T1738 |
T1737 |
amod |
dopaminergic,effects |
R1008 |
T1739 |
T1740 |
amod |
neuronal,restricted |
R1009 |
T1740 |
T1737 |
amod |
restricted,effects |
R1010 |
T1741 |
T1740 |
punct |
-,restricted |
R1011 |
T1742 |
T1737 |
prep |
of,effects |
R1012 |
T1743 |
T1742 |
pobj |
mutations,of |
R1013 |
T1744 |
T1743 |
prep |
in,mutations |
R1014 |
T1745 |
T1744 |
pobj |
parkin,in |
R1015 |
T1747 |
T1735 |
neg |
not,are |
R1016 |
T1748 |
T1735 |
acomp |
understood,are |
R1017 |
T1749 |
T1750 |
punct |
[,25 |
R1018 |
T1750 |
T1735 |
parataxis |
25,are |
R1019 |
T1751 |
T1750 |
punct |
],25 |
R1020 |
T1752 |
T1746 |
punct |
", ",exhibit |
R1021 |
T1753 |
T1754 |
nmod |
parkin,mice |
R1022 |
T1754 |
T1746 |
nsubj |
mice,exhibit |
R1023 |
T1755 |
T1753 |
punct |
−,parkin |
R1024 |
T1756 |
T1753 |
punct |
/,parkin |
R1025 |
T1757 |
T1753 |
punct |
−,parkin |
R1026 |
T1758 |
T1759 |
amod |
mitochondrial,dysfunction |
R1027 |
T1759 |
T1746 |
dobj |
dysfunction,exhibit |
R1028 |
T1760 |
T1759 |
cc |
and,dysfunction |
R1029 |
T1761 |
T1762 |
nmod |
energy,deficits |
R1030 |
T1762 |
T1759 |
conj |
deficits,dysfunction |
R1031 |
T1763 |
T1761 |
cc |
and,energy |
R1032 |
T1764 |
T1761 |
conj |
growth,energy |
R1033 |
T1765 |
T1746 |
punct |
", ",exhibit |
R1034 |
T1766 |
T1746 |
cc |
and,exhibit |
R1035 |
T1767 |
T1768 |
det |
a,fraction |
R1036 |
T1768 |
T1769 |
nsubj |
fraction,localizes |
R1037 |
T1815 |
T1814 |
pobj |
RanBP2,in |
R1038 |
T1769 |
T1746 |
conj |
localizes,exhibit |
R1039 |
T1816 |
T1815 |
cc |
and,RanBP2 |
R1040 |
T1770 |
T1768 |
prep |
of,fraction |
R1041 |
T1817 |
T1815 |
conj |
parkin,RanBP2 |
R1042 |
T1818 |
T1812 |
aux |
may,share |
R1043 |
T1819 |
T1820 |
punct |
(,physiological |
R1044 |
T1771 |
T1770 |
pobj |
parkin,of |
R1045 |
T1820 |
T1823 |
amod |
physiological,pathways |
R1046 |
T1821 |
T1820 |
advmod |
patho,physiological |
R1047 |
T1772 |
T1769 |
prep |
to,localizes |
R1048 |
T1822 |
T1820 |
punct |
),physiological |
R1049 |
T1823 |
T1812 |
dobj |
pathways,share |
R1050 |
T1824 |
T1812 |
cc |
and,share |
R1051 |
T1825 |
T1812 |
conj |
support,share |
R1052 |
T1826 |
T1827 |
det |
a,role |
R1053 |
T1827 |
T1825 |
dobj |
role,support |
R1054 |
T1773 |
T1774 |
det |
the,face |
R1055 |
T1828 |
T1827 |
amod |
multifaceted,role |
R1056 |
T1829 |
T1827 |
prep |
of,role |
R1057 |
T1830 |
T1829 |
pobj |
RanBP2,of |
R1058 |
T1831 |
T1810 |
punct |
.,suggest |
R1059 |
T1774 |
T1772 |
pobj |
face,to |
R1060 |
T1833 |
T1834 |
advmod |
Yet,remain |
R1061 |
T1775 |
T1774 |
amod |
cytoplasmic,face |
R1062 |
T1835 |
T1836 |
amod |
clear,functions |
R1063 |
T1836 |
T1834 |
nsubj |
functions,remain |
R1064 |
T1776 |
T1774 |
prep |
of,face |
R1065 |
T1837 |
T1836 |
prep |
of,functions |
R1066 |
T1838 |
T1837 |
pobj |
RanBP2,of |
R1067 |
T1839 |
T1836 |
prep |
in,functions |
R1068 |
T1777 |
T1778 |
det |
the,mitochondria |
R1069 |
T1840 |
T1841 |
nmod |
animal,physiology |
R1070 |
T1841 |
T1839 |
pobj |
physiology,in |
R1071 |
T1778 |
T1776 |
pobj |
mitochondria,of |
R1072 |
T1842 |
T1840 |
cc |
and,animal |
R1073 |
T1843 |
T1840 |
conj |
cell,animal |
R1074 |
T1844 |
T1834 |
acomp |
elusive,remain |
R1075 |
T1779 |
T1774 |
punct |
", ",face |
R1076 |
T1845 |
T1834 |
punct |
.,remain |
R1077 |
T1847 |
T1848 |
advmod |
Here,report |
R1078 |
T1780 |
T1781 |
advmod |
where,thought |
R1079 |
T1781 |
T1774 |
relcl |
thought,face |
R1080 |
T1849 |
T1848 |
punct |
", ",report |
R1081 |
T1850 |
T1848 |
nsubj |
we,report |
R1082 |
T1851 |
T1848 |
prep |
on,report |
R1083 |
T1782 |
T1781 |
advmod |
together,thought |
R1084 |
T1852 |
T1853 |
det |
the,identification |
R1085 |
T1783 |
T1782 |
prep |
with,together |
R1086 |
T1853 |
T1851 |
pobj |
identification,on |
R1087 |
T1854 |
T1853 |
cc |
and,identification |
R1088 |
T1855 |
T1853 |
conj |
function,identification |
R1089 |
T1784 |
T1785 |
amod |
other,partners |
R1090 |
T1856 |
T1853 |
prep |
of,identification |
R1091 |
T1857 |
T1858 |
nummod |
two,partners |
R1092 |
T1785 |
T1783 |
pobj |
partners,with |
R1093 |
T1858 |
T1856 |
pobj |
partners,of |
R1094 |
T1859 |
T1858 |
amod |
novel,partners |
R1095 |
T1860 |
T1858 |
prep |
of,partners |
R1096 |
T1786 |
T1781 |
auxpass |
is,thought |
R1097 |
T1861 |
T1860 |
pobj |
RanBP2,of |
R1098 |
T1862 |
T1858 |
punct |
", ",partners |
R1099 |
T1787 |
T1788 |
aux |
to,promote |
R1100 |
T1863 |
T1858 |
appos |
Cox11,partners |
R1101 |
T1864 |
T1863 |
cc |
and,Cox11 |
R1102 |
T1865 |
T1866 |
compound |
hexokinase,type |
R1103 |
T1788 |
T1781 |
xcomp |
promote,thought |
R1104 |
T1866 |
T1863 |
conj |
type,Cox11 |
R1105 |
T1867 |
T1866 |
nummod |
I,type |
R1106 |
T1868 |
T1866 |
punct |
(,type |
R1107 |
T1869 |
T1866 |
appos |
HKI,type |
R1108 |
T1870 |
T1858 |
punct |
),partners |
R1109 |
T1871 |
T1858 |
punct |
", ",partners |
R1110 |
T1789 |
T1790 |
det |
the,degradation |
R1111 |
T1872 |
T1873 |
dep |
which,interact |
R1112 |
T1873 |
T1858 |
relcl |
interact,partners |
R1113 |
T1874 |
T1873 |
prep |
with,interact |
R1114 |
T1790 |
T1788 |
dobj |
degradation,promote |
R1115 |
T1875 |
T1876 |
det |
a,domain |
R1116 |
T1876 |
T1874 |
pobj |
domain,with |
R1117 |
T1877 |
T1876 |
amod |
large,domain |
R1118 |
T1878 |
T1877 |
cc |
and,large |
R1119 |
T1791 |
T1790 |
prep |
of,degradation |
R1120 |
T1879 |
T1877 |
conj |
orphan,large |
R1121 |
T1880 |
T1876 |
prep |
of,domain |
R1122 |
T1792 |
T1793 |
amod |
selective,substrates |
R1123 |
T1881 |
T1880 |
pobj |
RanBP2,of |
R1124 |
T1882 |
T1876 |
punct |
", ",domain |
R1125 |
T1883 |
T1884 |
det |
the,domain |
R1126 |
T1793 |
T1791 |
pobj |
substrates,of |
R1127 |
T1884 |
T1876 |
appos |
domain,domain |
R1128 |
T1885 |
T1886 |
npadvmod |
leucine,rich |
R1129 |
T1886 |
T1884 |
amod |
rich,domain |
R1130 |
T1794 |
T1793 |
amod |
mitochondrial,substrates |
R1131 |
T1887 |
T1886 |
punct |
-,rich |
R1132 |
T1795 |
T1788 |
cc |
and,promote |
R1133 |
T1888 |
T1884 |
punct |
(,domain |
R1134 |
T1889 |
T1884 |
appos |
LD,domain |
R1135 |
T1890 |
T1851 |
punct |
),on |
R1136 |
T1891 |
T1851 |
punct |
;,on |
R1137 |
T1796 |
T1797 |
aux |
to,exert |
R1138 |
T1892 |
T1851 |
cc |
and,on |
R1139 |
T1893 |
T1851 |
conj |
on,on |
R1140 |
T1894 |
T1895 |
det |
the,outcome |
R1141 |
T1797 |
T1788 |
conj |
exert,promote |
R1142 |
T1895 |
T1893 |
pobj |
outcome,on |
R1143 |
T1896 |
T1895 |
prep |
of,outcome |
R1144 |
T1798 |
T1799 |
det |
a,function |
R1145 |
T1799 |
T1797 |
dobj |
function,exert |
R1146 |
T1897 |
T1898 |
amod |
partial,loss |
R1147 |
T1898 |
T1896 |
pobj |
loss,of |
R1148 |
T1800 |
T1799 |
amod |
neuroprotective,function |
R1149 |
T1899 |
T1898 |
punct |
-,loss |
R1150 |
T1900 |
T1898 |
prep |
of,loss |
R1151 |
T1901 |
T1900 |
punct |
-,of |
R1152 |
T1801 |
T1802 |
punct |
[,26 |
R1153 |
T1902 |
T1900 |
pobj |
function,of |
R1154 |
T1903 |
T1898 |
prep |
of,loss |
R1155 |
T1904 |
T1903 |
pobj |
RanBP2,of |
R1156 |
T1905 |
T1895 |
prep |
on,outcome |
R1157 |
T1906 |
T1905 |
pobj |
HKI,on |
R1158 |
T1907 |
T1906 |
punct |
", ",HKI |
R1159 |
T1802 |
T1797 |
parataxis |
26,exert |
R1160 |
T1908 |
T1909 |
compound |
animal,physiology |
R1161 |
T1909 |
T1906 |
conj |
physiology,HKI |
R1162 |
T1910 |
T1909 |
punct |
", ",physiology |
R1163 |
T1803 |
T1804 |
punct |
–,29 |
R1164 |
T1911 |
T1909 |
cc |
and,physiology |
R1165 |
T1912 |
T1913 |
compound |
glucose,energy |
R1166 |
T1913 |
T1915 |
compound |
energy,metabolism |
R1167 |
T1804 |
T1802 |
prep |
29,26 |
R1168 |
T1914 |
T1913 |
punct |
/,energy |
R1169 |
T1915 |
T1909 |
conj |
metabolism,physiology |
R1170 |
T1805 |
T1802 |
punct |
],26 |
R1171 |
T1916 |
T1848 |
punct |
.,report |
R1172 |
T1806 |
T1769 |
punct |
.,localizes |
R1173 |
T1808 |
T1809 |
det |
These,data |
R1174 |
T1809 |
T1810 |
nsubj |
data,suggest |
R1175 |
T1811 |
T1812 |
mark |
that,share |
R1176 |
T1812 |
T1810 |
ccomp |
share,suggest |
R1177 |
T1813 |
T1812 |
nsubj |
deficits,share |
R1178 |
T1814 |
T1813 |
prep |
in,deficits |
R338 |
T1039 |
T1040 |
det |
The,Nup358 |
R339 |
T1040 |
T1043 |
nsubj |
Nup358,is |
R340 |
T1041 |
T1040 |
compound |
RanBP2,Nup358 |
R341 |
T1042 |
T1040 |
punct |
/,Nup358 |
R342 |
T1044 |
T1045 |
det |
a,protein |
R343 |
T1045 |
T1043 |
attr |
protein,is |
R344 |
T1046 |
T1045 |
amod |
unique,protein |
R345 |
T1047 |
T1045 |
nmod |
vertebrate,protein |
R346 |
T1048 |
T1047 |
cc |
and,vertebrate |
R347 |
T1049 |
T1050 |
amod |
large,scaffold |
R348 |
T1050 |
T1047 |
conj |
scaffold,vertebrate |
R349 |
T1051 |
T1045 |
acl |
comprised,protein |
R350 |
T1052 |
T1051 |
prep |
of,comprised |
R351 |
T1053 |
T1054 |
amod |
multiple,domains |
R352 |
T1054 |
T1052 |
pobj |
domains,of |
R353 |
T1055 |
T1054 |
amod |
structural,domains |
R354 |
T1056 |
T1055 |
cc |
and,structural |
R355 |
T1057 |
T1055 |
conj |
functional,structural |
R356 |
T1058 |
T1059 |
punct |
[,1 |
R357 |
T1059 |
T1043 |
parataxis |
1,is |
R358 |
T1060 |
T1061 |
punct |
–,4 |
R359 |
T1061 |
T1059 |
prep |
4,1 |
R360 |
T1062 |
T1059 |
punct |
],1 |
R361 |
T1063 |
T1043 |
punct |
.,is |
R362 |
T1065 |
T1066 |
amod |
Several,roles |
R363 |
T1066 |
T1067 |
nsubj |
roles,emerged |
R364 |
T1068 |
T1066 |
prep |
of,roles |
R365 |
T1069 |
T1068 |
pobj |
RanBP2,of |
R366 |
T1070 |
T1067 |
aux |
have,emerged |
R367 |
T1071 |
T1072 |
dep |
that,implicate |
R368 |
T1072 |
T1067 |
ccomp |
implicate,emerged |
R369 |
T1073 |
T1072 |
dobj |
RanBP2,implicate |
R370 |
T1074 |
T1072 |
prep |
in,implicate |
R371 |
T1075 |
T1076 |
amod |
nucleocytoplasmic,trafficking |
R372 |
T1076 |
T1074 |
pobj |
trafficking,in |
R373 |
T1077 |
T1078 |
punct |
[,5 |
R374 |
T1078 |
T1076 |
parataxis |
5,trafficking |
R375 |
T1079 |
T1078 |
nummod |
3,5 |
R376 |
T1080 |
T1078 |
punct |
",",5 |
R377 |
T1081 |
T1078 |
punct |
],5 |
R378 |
T1082 |
T1076 |
punct |
", ",trafficking |
R379 |
T1083 |
T1084 |
compound |
protein,biogenesis |
R380 |
T1084 |
T1076 |
conj |
biogenesis,trafficking |
R381 |
T1085 |
T1086 |
punct |
[,7 |
R382 |
T1086 |
T1084 |
parataxis |
7,biogenesis |
R383 |
T1087 |
T1086 |
nummod |
6,7 |
R384 |
T1088 |
T1086 |
punct |
",",7 |
R385 |
T1089 |
T1086 |
punct |
],7 |
R386 |
T1090 |
T1084 |
punct |
", ",biogenesis |
R387 |
T1091 |
T1092 |
det |
the,formation |
R388 |
T1092 |
T1084 |
conj |
formation,biogenesis |
R389 |
T1093 |
T1092 |
prep |
of,formation |
R390 |
T1094 |
T1095 |
det |
the,spindle |
R391 |
T1095 |
T1093 |
pobj |
spindle,of |
R392 |
T1096 |
T1095 |
amod |
mitotic,spindle |
R393 |
T1097 |
T1092 |
punct |
", ",formation |
R394 |
T1098 |
T1092 |
conj |
assembly,formation |
R395 |
T1099 |
T1098 |
prep |
of,assembly |
R396 |
T1100 |
T1101 |
det |
the,envelope |
R397 |
T1101 |
T1099 |
pobj |
envelope,of |
R398 |
T1102 |
T1101 |
amod |
nuclear,envelope |
R399 |
T1103 |
T1104 |
punct |
[,8 |
R400 |
T1104 |
T1098 |
parataxis |
8,assembly |
R401 |
T1105 |
T1104 |
punct |
],8 |
R402 |
T1106 |
T1098 |
punct |
", ",assembly |
R403 |
T1107 |
T1098 |
cc |
and,assembly |
R404 |
T1108 |
T1109 |
det |
the,integration |
R405 |
T1109 |
T1098 |
conj |
integration,assembly |
R406 |
T1110 |
T1109 |
prep |
of,integration |
R407 |
T1111 |
T1112 |
det |
the,breakdown |
R408 |
T1112 |
T1110 |
pobj |
breakdown,of |
R409 |
T1113 |
T1114 |
amod |
nuclear,envelope |
R410 |
T1114 |
T1112 |
compound |
envelope,breakdown |
R411 |
T1115 |
T1109 |
prep |
with,integration |
R412 |
T1116 |
T1117 |
compound |
kinetochore,formation |
R413 |
T1117 |
T1115 |
pobj |
formation,with |
R414 |
T1118 |
T1117 |
cc |
and,formation |
R415 |
T1119 |
T1117 |
conj |
maturation,formation |
R416 |
T1120 |
T1109 |
prep |
during,integration |
R417 |
T1121 |
T1122 |
amod |
early,progression |
R418 |
T1122 |
T1120 |
pobj |
progression,during |
R419 |
T1123 |
T1122 |
amod |
mitotic,progression |
R420 |
T1124 |
T1125 |
punct |
[,9 |
R421 |
T1125 |
T1109 |
parataxis |
9,integration |
R422 |
T1126 |
T1125 |
punct |
],9 |
R423 |
T1127 |
T1067 |
punct |
.,emerged |
R424 |
T1129 |
T1130 |
det |
The,interaction |
R425 |
T1130 |
T1132 |
nsubj |
interaction,reflects |
R426 |
T1131 |
T1130 |
amod |
specific,interaction |
R427 |
T1133 |
T1130 |
prep |
of,interaction |
R428 |
T1134 |
T1133 |
pobj |
RanBP2,of |
R429 |
T1135 |
T1130 |
prep |
with,interaction |
R430 |
T1136 |
T1137 |
det |
a,set |
R431 |
T1137 |
T1135 |
pobj |
set,with |
R432 |
T1138 |
T1137 |
amod |
diverse,set |
R433 |
T1139 |
T1137 |
prep |
of,set |
R434 |
T1140 |
T1139 |
pobj |
partners,of |
R435 |
T1141 |
T1132 |
advmod |
likely,reflects |
R436 |
T1142 |
T1143 |
det |
a,role |
R437 |
T1143 |
T1132 |
dobj |
role,reflects |
R438 |
T1144 |
T1143 |
amod |
pleiotropic,role |
R439 |
T1145 |
T1143 |
prep |
of,role |
R440 |
T1146 |
T1145 |
pobj |
RanBP2,of |
R441 |
T1147 |
T1143 |
prep |
in,role |
R442 |
T1148 |
T1149 |
compound |
cell,function |
R443 |
T1149 |
T1147 |
pobj |
function,in |
R444 |
T1150 |
T1143 |
punct |
", ",role |
R445 |
T1151 |
T1152 |
advmod |
possibly,through |
R446 |
T1152 |
T1143 |
prep |
through,role |
R447 |
T1153 |
T1154 |
det |
the,integration |
R448 |
T1154 |
T1152 |
pobj |
integration,through |
R449 |
T1155 |
T1154 |
prep |
of,integration |
R450 |
T1156 |
T1157 |
amod |
multiple,pathways |
R451 |
T1157 |
T1155 |
pobj |
pathways,of |
R452 |
T1158 |
T1132 |
punct |
.,reflects |
R453 |
T1160 |
T1161 |
prep |
On,impart |
R454 |
T1162 |
T1163 |
det |
the,hand |
R455 |
T1163 |
T1160 |
pobj |
hand,On |
R456 |
T1164 |
T1163 |
amod |
other,hand |
R457 |
T1165 |
T1161 |
punct |
", ",impart |
R458 |
T1166 |
T1167 |
det |
the,interaction |
R459 |
T1167 |
T1161 |
nsubj |
interaction,impart |
R460 |
T1168 |
T1169 |
npadvmod |
cell,selective |
R461 |
T1169 |
T1167 |
amod |
selective,interaction |
R462 |
T1170 |
T1168 |
punct |
(,cell |
R463 |
T1171 |
T1168 |
appos |
tissue,cell |
R464 |
T1172 |
T1169 |
punct |
),selective |
R465 |
T1173 |
T1169 |
punct |
-,selective |
R466 |
T1174 |
T1167 |
prep |
of,interaction |
R467 |
T1175 |
T1174 |
pobj |
RanBP2,of |
R468 |
T1176 |
T1167 |
prep |
with,interaction |
R469 |
T1177 |
T1176 |
pobj |
some,with |
R470 |
T1178 |
T1177 |
prep |
of,some |
R471 |
T1179 |
T1180 |
poss |
its,partners |
R472 |
T1180 |
T1178 |
pobj |
partners,of |
R473 |
T1181 |
T1161 |
aux |
may,impart |
R474 |
T1182 |
T1161 |
advmod |
also,impart |
R475 |
T1183 |
T1184 |
npadvmod |
cell,restricted |
R476 |
T1184 |
T1186 |
amod |
restricted,roles |
R477 |
T1185 |
T1184 |
punct |
-,restricted |
R478 |
T1186 |
T1161 |
dobj |
roles,impart |
R479 |
T1187 |
T1161 |
prep |
to,impart |
R480 |
T1188 |
T1187 |
pobj |
RanBP2,to |
R481 |
T1189 |
T1161 |
punct |
.,impart |
R482 |
T1191 |
T1192 |
prep |
For,associate |
R483 |
T1193 |
T1191 |
pobj |
example,For |
R484 |
T1194 |
T1192 |
punct |
", ",associate |
R485 |
T1195 |
T1196 |
det |
the,domains |
R486 |
T1196 |
T1192 |
nsubj |
domains,associate |
R487 |
T1197 |
T1198 |
npadvmod |
Ran,binding |
R488 |
T1198 |
T1196 |
amod |
binding,domains |
R489 |
T1199 |
T1198 |
punct |
-,binding |
R490 |
T1200 |
T1201 |
nsubj |
RBDn,1 |
R491 |
T1201 |
T1196 |
appos |
1,domains |
R492 |
T1202 |
T1201 |
punct |
=,1 |
R493 |
T1203 |
T1204 |
punct |
-,4 |
R494 |
T1204 |
T1201 |
prep |
4,1 |
R495 |
T1205 |
T1196 |
prep |
of,domains |
R496 |
T1206 |
T1205 |
pobj |
RanBP2,of |
R497 |
T1207 |
T1192 |
prep |
with,associate |
R498 |
T1208 |
T1209 |
det |
the,co-receptor |
R499 |
T1209 |
T1207 |
pobj |
co-receptor,with |
R500 |
T1210 |
T1209 |
amod |
nuclear,co-receptor |
R501 |
T1211 |
T1209 |
compound |
import,co-receptor |
R502 |
T1212 |
T1209 |
punct |
", ",co-receptor |
R503 |
T1213 |
T1214 |
compound |
importin,β |
R504 |
T1214 |
T1209 |
appos |
β,co-receptor |
R505 |
T1215 |
T1214 |
punct |
-,β |
R506 |
T1216 |
T1217 |
punct |
[,11 |
R507 |
T1217 |
T1192 |
parataxis |
11,associate |
R508 |
T1218 |
T1217 |
nummod |
10,11 |
R509 |
T1219 |
T1217 |
punct |
",",11 |
R510 |
T1220 |
T1217 |
punct |
],11 |
R511 |
T1221 |
T1192 |
punct |
", ",associate |
R512 |
T1222 |
T1192 |
cc |
and,associate |
R513 |
T1223 |
T1224 |
nsubj |
antibodies,inhibit |
R514 |
T1224 |
T1192 |
conj |
inhibit,associate |
R515 |
T1225 |
T1223 |
prep |
against,antibodies |
R516 |
T1226 |
T1225 |
pobj |
RanBP2,against |
R517 |
T1227 |
T1228 |
det |
the,pathway |
R518 |
T1228 |
T1224 |
dobj |
pathway,inhibit |
R519 |
T1229 |
T1230 |
amod |
nuclear,import |
R520 |
T1230 |
T1228 |
compound |
import,pathway |
R521 |
T1231 |
T1228 |
prep |
in,pathway |
R522 |
T1232 |
T1233 |
compound |
HeLa,cells |
R523 |
T1233 |
T1231 |
pobj |
cells,in |
R524 |
T1234 |
T1235 |
punct |
[,3 |
R525 |
T1235 |
T1224 |
parataxis |
3,inhibit |
R526 |
T1236 |
T1235 |
punct |
],3 |
R527 |
T1237 |
T1224 |
punct |
;,inhibit |
R528 |
T1238 |
T1224 |
cc |
but,inhibit |
R529 |
T1239 |
T1240 |
predet |
such,role |
R530 |
T1240 |
T1242 |
nsubj |
role,seems |
R531 |
T1241 |
T1240 |
det |
a,role |
R532 |
T1242 |
T1224 |
conj |
seems,inhibit |
R533 |
T1243 |
T1242 |
oprd |
dispensable,seems |
R534 |
T1244 |
T1242 |
prep |
in,seems |
R535 |
T1245 |
T1246 |
compound |
Xenopus,oocytes |
R536 |
T1246 |
T1244 |
pobj |
oocytes,in |
R537 |
T1247 |
T1248 |
punct |
[,12 |
R538 |
T1248 |
T1242 |
parataxis |
12,seems |
R539 |
T1249 |
T1248 |
punct |
],12 |
R540 |
T1250 |
T1242 |
punct |
.,seems |
R541 |
T1252 |
T1253 |
prep |
In,associates |
R542 |
T1254 |
T1252 |
pobj |
addition,In |
R543 |
T1255 |
T1253 |
punct |
", ",associates |
R544 |
T1256 |
T1257 |
det |
the,combination |
R545 |
T1257 |
T1253 |
nsubj |
combination,associates |
R546 |
T1258 |
T1257 |
prep |
of,combination |
R547 |
T1259 |
T1260 |
det |
the,domains |
R548 |
T1260 |
T1258 |
pobj |
domains,of |
R549 |
T1261 |
T1262 |
npadvmod |
C,terminal |
R550 |
T1262 |
T1260 |
amod |
terminal,domains |
R551 |
T1263 |
T1262 |
punct |
-,terminal |
R552 |
T1264 |
T1260 |
punct |
", ",domains |
R553 |
T1265 |
T1260 |
appos |
RBD4,domains |
R554 |
T1266 |
T1265 |
cc |
and,RBD4 |
R555 |
T1267 |
T1265 |
conj |
CY,RBD4 |
R556 |
T1268 |
T1260 |
punct |
(,domains |
R557 |
T1269 |
T1260 |
prep |
of,domains |
R558 |
T1270 |
T1269 |
pobj |
RanBP2,of |
R559 |
T1271 |
T1253 |
punct |
),associates |
R560 |
T1272 |
T1253 |
punct |
", ",associates |
R561 |
T1273 |
T1253 |
prep |
with,associates |
R562 |
T1274 |
T1275 |
det |
a,subset |
R563 |
T1275 |
T1273 |
pobj |
subset,with |
R564 |
T1276 |
T1275 |
prep |
of,subset |
R565 |
T1277 |
T1278 |
compound |
G,protein |
R566 |
T1278 |
T1279 |
npadvmod |
protein,coupled |
R567 |
T1279 |
T1281 |
amod |
coupled,receptors |
R568 |
T1280 |
T1279 |
punct |
-,coupled |
R569 |
T1281 |
T1276 |
pobj |
receptors,of |
R570 |
T1282 |
T1275 |
punct |
", ",subset |
R571 |
T1283 |
T1284 |
det |
the,opsin |
R572 |
T1284 |
T1275 |
appos |
opsin,subset |
R573 |
T1285 |
T1286 |
amod |
red,green |
R574 |
T1286 |
T1284 |
amod |
green,opsin |
R575 |
T1287 |
T1286 |
punct |
/,green |
R576 |
T1288 |
T1284 |
punct |
", ",opsin |
R577 |
T1289 |
T1284 |
acl |
expressed,opsin |
R578 |
T1290 |
T1289 |
prep |
in,expressed |
R579 |
T1291 |
T1292 |
amod |
photosensory,neurons |
R580 |
T1292 |
T1290 |
pobj |
neurons,in |
R581 |
T1293 |
T1253 |
cc |
and,associates |
R582 |
T1294 |
T1253 |
conj |
enhances,associates |
R583 |
T1295 |
T1296 |
nmod |
opsin,production |
R584 |
T1296 |
T1294 |
dobj |
production,enhances |
R585 |
T1297 |
T1296 |
amod |
functional,production |
R586 |
T1298 |
T1299 |
punct |
[,7 |
R587 |
T1299 |
T1294 |
parataxis |
7,enhances |
R588 |
T1300 |
T1299 |
nummod |
6,7 |
R589 |
T1301 |
T1299 |
punct |
",",7 |
R590 |
T1302 |
T1299 |
punct |
],7 |
R591 |
T1303 |
T1253 |
punct |
", ",associates |
R592 |
T1304 |
T1305 |
mark |
while,occurs |
R593 |
T1305 |
T1253 |
advcl |
occurs,associates |
R594 |
T1306 |
T1307 |
det |
the,interaction |
R595 |
T1307 |
T1305 |
nsubj |
interaction,occurs |
R596 |
T1308 |
T1307 |
prep |
of,interaction |
R597 |
T1309 |
T1310 |
det |
the,KBD |
R598 |
T1310 |
T1308 |
pobj |
KBD,of |
R599 |
T1311 |
T1310 |
prep |
of,KBD |
R600 |
T1312 |
T1311 |
pobj |
RanBP2,of |
R601 |
T1313 |
T1307 |
prep |
with,interaction |
R602 |
T1314 |
T1315 |
det |
a,subset |
R603 |
T1315 |
T1313 |
pobj |
subset,with |
R604 |
T1316 |
T1315 |
prep |
of,subset |
R605 |
T1317 |
T1318 |
det |
the,proteins |
R606 |
T1318 |
T1316 |
pobj |
proteins,of |
R607 |
T1319 |
T1318 |
amod |
conventional,proteins |
R608 |
T1320 |
T1321 |
npadvmod |
microtubule,based |
R609 |
T1321 |
T1318 |
amod |
based,proteins |
R610 |
T1322 |
T1321 |
punct |
-,based |
R611 |
T1323 |
T1318 |
compound |
motor,proteins |
R612 |
T1324 |
T1315 |
punct |
", ",subset |
R613 |
T1325 |
T1326 |
det |
the,kinesins |
R614 |
T1326 |
T1315 |
appos |
kinesins,subset |
R615 |
T1327 |
T1326 |
punct |
", ",kinesins |
R616 |
T1328 |
T1326 |
appos |
KIF5B,kinesins |
R617 |
T1329 |
T1328 |
cc |
and,KIF5B |
R618 |
T1330 |
T1328 |
conj |
KIF5C,KIF5B |
R619 |
T1331 |
T1305 |
punct |
", ",occurs |
R620 |
T1332 |
T1305 |
advmod |
selectively,occurs |
R621 |
T1333 |
T1305 |
prep |
in,occurs |
R622 |
T1334 |
T1335 |
det |
the,system |
R623 |
T1335 |
T1333 |
pobj |
system,in |
R624 |
T1336 |
T1335 |
amod |
central,system |
R625 |
T1337 |
T1335 |
amod |
nervous,system |
R626 |
T1338 |
T1335 |
punct |
(,system |
R627 |
T1339 |
T1335 |
appos |
CNS,system |
R628 |
T1340 |
T1305 |
punct |
),occurs |
R629 |
T1341 |
T1342 |
punct |
[,13 |
R630 |
T1342 |
T1305 |
parataxis |
13,occurs |
R631 |
T1343 |
T1342 |
punct |
],13 |
R632 |
T1344 |
T1253 |
punct |
.,associates |
R633 |
T1346 |
T1347 |
det |
A,set |
R634 |
T1347 |
T1349 |
nsubj |
set,are |
R635 |
T1348 |
T1347 |
amod |
diverse,set |
R636 |
T1350 |
T1347 |
prep |
of,set |
R637 |
T1351 |
T1352 |
amod |
additional,partners |
R638 |
T1352 |
T1350 |
pobj |
partners,of |
R639 |
T1353 |
T1352 |
amod |
molecular,partners |
R640 |
T1354 |
T1347 |
punct |
", ",set |
R641 |
T1355 |
T1347 |
appos |
each,set |
R642 |
T1356 |
T1355 |
acl |
associating,each |
R643 |
T1357 |
T1356 |
advmod |
specifically,associating |
R644 |
T1358 |
T1356 |
prep |
with,associating |
R645 |
T1359 |
T1360 |
det |
a,domain |
R646 |
T1360 |
T1358 |
pobj |
domain,with |
R647 |
T1361 |
T1360 |
amod |
selective,domain |
R648 |
T1362 |
T1360 |
prep |
of,domain |
R649 |
T1363 |
T1362 |
pobj |
RanBP2,of |
R650 |
T1364 |
T1349 |
punct |
", ",are |
R651 |
T1365 |
T1349 |
acomp |
likely,are |
R652 |
T1366 |
T1367 |
aux |
to,impart |
R653 |
T1367 |
T1365 |
xcomp |
impart,likely |
R654 |
T1368 |
T1367 |
cc |
and,impart |
R655 |
T1369 |
T1367 |
conj |
integrate,impart |
R656 |
T1370 |
T1371 |
amod |
additional,roles |
R657 |
T1371 |
T1369 |
dobj |
roles,integrate |
R658 |
T1372 |
T1371 |
prep |
to,roles |
R659 |
T1373 |
T1372 |
pobj |
RanBP2,to |
R660 |
T1374 |
T1349 |
punct |
.,are |
R661 |
T1376 |
T1377 |
prep |
For,associate |
R662 |
T1378 |
T1376 |
pobj |
example,For |
R663 |
T1379 |
T1377 |
punct |
", ",associate |
R664 |
T1380 |
T1381 |
det |
the,domain |
R665 |
T1381 |
T1377 |
nsubj |
domain,associate |
R666 |
T1382 |
T1383 |
npadvmod |
cyclophilin,like |
R667 |
T1383 |
T1381 |
amod |
like,domain |
R668 |
T1384 |
T1383 |
punct |
-,like |
R669 |
T1385 |
T1381 |
punct |
(,domain |
R670 |
T1386 |
T1381 |
appos |
CLD,domain |
R671 |
T1387 |
T1381 |
punct |
),domain |
R672 |
T1388 |
T1381 |
punct |
", ",domain |
R673 |
T1389 |
T1390 |
det |
the,domains |
R674 |
T1390 |
T1381 |
appos |
domains,domain |
R675 |
T1391 |
T1392 |
amod |
internal,repeat |
R676 |
T1392 |
T1390 |
nmod |
repeat,domains |
R677 |
T1393 |
T1394 |
punct |
(,IR |
R678 |
T1394 |
T1392 |
parataxis |
IR,repeat |
R679 |
T1395 |
T1394 |
compound |
W1W2,IR |
R680 |
T1396 |
T1394 |
punct |
/,IR |
R681 |
T1397 |
T1394 |
punct |
),IR |
R682 |
T1398 |
T1392 |
punct |
", ",repeat |
R683 |
T1399 |
T1392 |
cc |
and,repeat |
R684 |
T1400 |
T1401 |
compound |
zinc,finger |
R685 |
T1401 |
T1403 |
npadvmod |
finger,rich |
R686 |
T1402 |
T1401 |
punct |
-,finger |
R687 |
T1403 |
T1392 |
conj |
rich,repeat |
R688 |
T1404 |
T1405 |
punct |
(,ZnF |
R689 |
T1405 |
T1403 |
parataxis |
ZnF,rich |
R690 |
T1406 |
T1405 |
punct |
),ZnF |
R691 |
T1407 |
T1381 |
prep |
of,domain |
R692 |
T1408 |
T1407 |
pobj |
RanBP2,of |
R693 |
T1409 |
T1377 |
advmod |
specifically,associate |
R694 |
T1410 |
T1377 |
prep |
with,associate |
R695 |
T1411 |
T1410 |
pobj |
components,with |
R696 |
T1412 |
T1411 |
prep |
of,components |
R697 |
T1413 |
T1414 |
det |
the,cap |
R698 |
T1414 |
T1412 |
pobj |
cap,of |
R699 |
T1415 |
T1414 |
compound |
19S,cap |
R700 |
T1416 |
T1414 |
prep |
of,cap |
R701 |
T1417 |
T1418 |
det |
the,proteasome |
R702 |
T1418 |
T1416 |
pobj |
proteasome,of |
R703 |
T1419 |
T1420 |
punct |
[,14 |
R704 |
T1420 |
T1414 |
parataxis |
14,cap |
R705 |
T1421 |
T1420 |
punct |
],14 |
R706 |
T1422 |
T1414 |
punct |
", ",cap |
R707 |
T1423 |
T1424 |
det |
the,enzyme |
R708 |
T1424 |
T1414 |
conj |
enzyme,cap |
R709 |
T1425 |
T1424 |
nmod |
E2,enzyme |
R710 |
T1426 |
T1427 |
npadvmod |
SUMO,conjugating |
R711 |
T1427 |
T1424 |
amod |
conjugating,enzyme |
R712 |
T1428 |
T1426 |
punct |
-,SUMO |
R713 |
T1429 |
T1426 |
nummod |
1,SUMO |
R714 |
T1430 |
T1426 |
punct |
-,SUMO |
R715 |
T1431 |
T1424 |
punct |
(,enzyme |
R716 |
T1432 |
T1424 |
appos |
Ubc9,enzyme |
R717 |
T1433 |
T1424 |
punct |
),enzyme |
R718 |
T1434 |
T1435 |
punct |
[,15 |
R719 |
T1435 |
T1424 |
parataxis |
15,enzyme |
R720 |
T1436 |
T1435 |
punct |
],15 |
R721 |
T1437 |
T1424 |
punct |
", ",enzyme |
R722 |
T1438 |
T1424 |
cc |
and,enzyme |
R723 |
T1439 |
T1440 |
det |
the,receptor |
R724 |
T1440 |
T1424 |
conj |
receptor,enzyme |
R725 |
T1441 |
T1442 |
amod |
nuclear,export |
R726 |
T1442 |
T1440 |
compound |
export,receptor |
R727 |
T1443 |
T1440 |
punct |
", ",receptor |
R728 |
T1444 |
T1445 |
compound |
CRM1,exportin |
R729 |
T1445 |
T1440 |
appos |
exportin,receptor |
R730 |
T1446 |
T1445 |
punct |
/,exportin |
R731 |
T1447 |
T1445 |
punct |
-,exportin |
R732 |
T1448 |
T1445 |
nummod |
1,exportin |
R733 |
T1449 |
T1450 |
punct |
[,16 |
R734 |
T1450 |
T1440 |
parataxis |
16,receptor |
R735 |
T1451 |
T1450 |
punct |
],16 |
R736 |
T1452 |
T1377 |
punct |
", ",associate |
R737 |
T1453 |
T1377 |
advmod |
respectively,associate |
R738 |
T1454 |
T1377 |
punct |
.,associate |
R739 |
T1456 |
T1457 |
nsubjpass |
RanBP2,found |
R740 |
T1458 |
T1457 |
npadvmod |
itself,found |
R741 |
T1459 |
T1457 |
auxpass |
was,found |
R742 |
T1460 |
T1457 |
advmod |
also,found |
R743 |
T1461 |
T1462 |
aux |
to,exhibit |
R744 |
T1462 |
T1457 |
xcomp |
exhibit,found |
R745 |
T1463 |
T1464 |
compound |
SUMO1,ligase |
R746 |
T1464 |
T1466 |
compound |
ligase,activity |
R747 |
T1465 |
T1464 |
compound |
E3,ligase |
R748 |
T1466 |
T1462 |
dobj |
activity,exhibit |
R749 |
T1467 |
T1468 |
punct |
[,17 |
R750 |
T1468 |
T1462 |
parataxis |
17,exhibit |
R751 |
T1469 |
T1468 |
punct |
],17 |
R752 |
T1470 |
T1462 |
punct |
", ",exhibit |
R753 |
T1471 |
T1462 |
advcl |
supporting,exhibit |
R754 |
T1472 |
T1473 |
det |
a,link |
R755 |
T1473 |
T1471 |
dobj |
link,supporting |
R756 |
T1474 |
T1473 |
amod |
direct,link |
R757 |
T1475 |
T1473 |
prep |
between,link |
R758 |
T1476 |
T1477 |
npadvmod |
RanBP2,mediated |
R759 |
T1477 |
T1479 |
amod |
mediated,modification |
R760 |
T1478 |
T1477 |
punct |
-,mediated |
R761 |
T1479 |
T1475 |
pobj |
modification,between |
R762 |
T1480 |
T1481 |
nmod |
SUMO,substrate |
R763 |
T1481 |
T1479 |
compound |
substrate,modification |
R764 |
T1482 |
T1480 |
punct |
-,SUMO |
R765 |
T1483 |
T1480 |
nummod |
1,SUMO |
R766 |
T1484 |
T1479 |
cc |
and,modification |
R767 |
T1485 |
T1479 |
conj |
relocation,modification |
R768 |
T1486 |
T1485 |
prep |
of,relocation |
R769 |
T1487 |
T1488 |
npadvmod |
SUMO,modified |
R770 |
T1488 |
T1491 |
amod |
modified,substrates |
R771 |
T1489 |
T1487 |
punct |
-,SUMO |
R772 |
T1490 |
T1487 |
nummod |
1,SUMO |
R773 |
T1491 |
T1486 |
pobj |
substrates,of |
R774 |
T1492 |
T1491 |
amod |
cytosolic,substrates |
R775 |
T1493 |
T1491 |
punct |
(,substrates |
R776 |
T1494 |
T1495 |
advmod |
e.g.,RanGAP |
R777 |
T1495 |
T1491 |
appos |
RanGAP,substrates |
R778 |
T1496 |
T1495 |
punct |
", ",RanGAP |
R779 |
T1497 |
T1485 |
punct |
),relocation |
R780 |
T1498 |
T1485 |
prep |
to,relocation |
R781 |
T1499 |
T1500 |
det |
the,face |
R782 |
T1500 |
T1498 |
pobj |
face,to |
R783 |
T1501 |
T1500 |
amod |
cytosolic,face |
R784 |
T1502 |
T1500 |
prep |
of,face |
R785 |
T1503 |
T1504 |
det |
the,complex |
R786 |
T1504 |
T1502 |
pobj |
complex,of |
R787 |
T1505 |
T1504 |
amod |
nuclear,complex |
R788 |
T1506 |
T1504 |
compound |
pore,complex |
R789 |
T1507 |
T1504 |
punct |
(,complex |
R790 |
T1508 |
T1504 |
appos |
NPC,complex |
R791 |
T1509 |
T1471 |
punct |
),supporting |
R792 |
T1510 |
T1511 |
punct |
[,18 |
R793 |
T1511 |
T1471 |
parataxis |
18,supporting |
R794 |
T1512 |
T1511 |
punct |
],18 |
R795 |
T1513 |
T1457 |
punct |
.,found |
R796 |
T1515 |
T1516 |
advmod |
Finally,found |
R797 |
T1517 |
T1516 |
punct |
", ",found |
R798 |
T1518 |
T1516 |
nsubjpass |
RanBP2,found |
R799 |
T1519 |
T1516 |
auxpass |
was,found |
R800 |
T1520 |
T1516 |
advmod |
also,found |
R801 |
T1521 |
T1522 |
aux |
to,localize |
R802 |
T1522 |
T1516 |
xcomp |
localize,found |
R803 |
T1523 |
T1522 |
advmod |
prominently,localize |
R804 |
T1524 |
T1522 |
prep |
to,localize |
R805 |
T1525 |
T1526 |
det |
the,compartment |
R806 |
T1526 |
T1524 |
pobj |
compartment,to |
R807 |
T1527 |
T1528 |
npadvmod |
mitochondria,rich |
R808 |
T1528 |
T1526 |
amod |
rich,compartment |
R809 |
T1529 |
T1528 |
punct |
-,rich |
R810 |
T1530 |
T1526 |
amod |
ellipsoid,compartment |
R811 |
T1531 |
T1526 |
amod |
subcellular,compartment |
R812 |
T1532 |
T1526 |
prep |
of,compartment |
R813 |
T1533 |
T1534 |
amod |
photosensory,neurons |
R814 |
T1534 |
T1532 |
pobj |
neurons,of |
R815 |
T1535 |
T1536 |
punct |
[,19 |
R816 |
T1536 |
T1526 |
parataxis |
19,compartment |
R817 |
T1537 |
T1536 |
punct |
],19 |
R818 |
T1538 |
T1524 |
cc |
and,to |
R819 |
T1539 |
T1524 |
conj |
to,to |
R820 |
T1540 |
T1541 |
npadvmod |
RanGTPase,restricted |
R821 |
T1541 |
T1543 |
amod |
restricted,foci |
R822 |
T1542 |
T1541 |
punct |
-,restricted |
R823 |
T1543 |
T1539 |
pobj |
foci,to |
R824 |
T1544 |
T1543 |
prep |
along,foci |
R825 |
T1545 |
T1546 |
amod |
cytoplasmic,tracks |
R826 |
T1546 |
T1544 |
pobj |
tracks,along |
R827 |
T1547 |
T1548 |
punct |
[,19 |
R828 |
T1548 |
T1546 |
parataxis |
19,tracks |
R829 |
T1549 |
T1548 |
punct |
],19 |
R830 |
T1550 |
T1522 |
punct |
", ",localize |
R831 |
T1551 |
T1522 |
prep |
in,localize |
R832 |
T1552 |
T1551 |
pobj |
addition,in |
R833 |
T1553 |
T1552 |
prep |
to,addition |
R834 |
T1554 |
T1555 |
poss |
its,localization |
R835 |
T1555 |
T1553 |
pobj |
localization,to |
R836 |
T1556 |
T1555 |
prep |
at,localization |
R837 |
T1557 |
T1558 |
amod |
cytoplasmic,fibrils |
R838 |
T1558 |
T1556 |
pobj |
fibrils,at |
R839 |
T1559 |
T1558 |
acl |
emanating,fibrils |
R840 |
T1560 |
T1559 |
prep |
from,emanating |
R841 |
T1561 |
T1562 |
amod |
nuclear,pores |
R842 |
T1562 |
T1560 |
pobj |
pores,from |
R843 |
T1563 |
T1564 |
punct |
[,19 |
R844 |
T1564 |
T1522 |
parataxis |
19,localize |
R845 |
T1565 |
T1564 |
nummod |
2,19 |
R846 |
T1566 |
T1564 |
punct |
",",19 |
R847 |
T1567 |
T1564 |
nummod |
3,19 |
R848 |
T1568 |
T1564 |
punct |
",",19 |
R849 |
T1569 |
T1564 |
nummod |
10,19 |
R850 |
T1570 |
T1564 |
punct |
",",19 |
R851 |
T1571 |
T1564 |
nummod |
12,19 |
R852 |
T1572 |
T1564 |
punct |
",",19 |
R853 |
T1573 |
T1564 |
punct |
],19 |
R854 |
T1574 |
T1516 |
punct |
.,found |
R855 |
T1576 |
T1577 |
amod |
Emerging,evidence |
R856 |
T1577 |
T1578 |
nsubj |
evidence,supports |
R857 |
T1579 |
T1580 |
mark |
that,underlie |
R858 |
T1580 |
T1578 |
ccomp |
underlie,supports |
R859 |
T1581 |
T1582 |
det |
the,effects |
R860 |
T1582 |
T1580 |
nsubj |
effects,underlie |
R861 |
T1583 |
T1584 |
npadvmod |
CNS,selective |
R862 |
T1584 |
T1582 |
amod |
selective,effects |
R863 |
T1585 |
T1584 |
punct |
-,selective |
R864 |
T1586 |
T1582 |
prep |
of,effects |
R865 |
T1587 |
T1586 |
pobj |
RanBP2,of |
R866 |
T1588 |
T1580 |
aux |
may,underlie |
R867 |
T1589 |
T1580 |
advmod |
also,underlie |
R868 |
T1590 |
T1591 |
det |
the,pathogenesis |
R869 |
T1591 |
T1580 |
dobj |
pathogenesis,underlie |
R870 |
T1592 |
T1591 |
prep |
of,pathogenesis |
R871 |
T1593 |
T1594 |
amod |
certain,neuropathies |
R872 |
T1594 |
T1592 |
pobj |
neuropathies,of |
R873 |
T1595 |
T1578 |
punct |
.,supports |
R874 |
T1597 |
T1598 |
nsubjpass |
Parkin,expressed |
R875 |
T1599 |
T1598 |
auxpass |
is,expressed |
R876 |
T1600 |
T1598 |
advmod |
ubiquitously,expressed |
R877 |
T1601 |
T1598 |
cc |
and,expressed |
R878 |
T1602 |
T1598 |
conj |
interacts,expressed |
R879 |
T1603 |
T1602 |
prep |
with,interacts |
R880 |
T1604 |
T1605 |
det |
the,domain |
R881 |
T1605 |
T1603 |
pobj |
domain,with |
R882 |
T1606 |
T1607 |
npadvmod |
Ubc9,interacting |
R883 |
T1607 |
T1605 |
amod |
interacting,domain |
R884 |
T1608 |
T1607 |
punct |
-,interacting |
R885 |
T1609 |
T1605 |
prep |
of,domain |
R886 |
T1610 |
T1609 |
pobj |
RanBP2,of |
R887 |
T1611 |
T1612 |
punct |
[,20 |
R888 |
T1612 |
T1602 |
parataxis |
20,interacts |
R889 |
T1613 |
T1612 |
punct |
],20 |
R890 |
T1614 |
T1598 |
punct |
.,expressed |
R891 |
T1616 |
T1617 |
nsubj |
This,promotes |
R892 |
T1618 |
T1619 |
det |
the,ubiquitination |
R893 |
T1619 |
T1617 |
dobj |
ubiquitination,promotes |
R894 |
T1620 |
T1619 |
cc |
and,ubiquitination |
R895 |
T1621 |
T1619 |
conj |
degradation,ubiquitination |
R896 |
T1622 |
T1619 |
prep |
of,ubiquitination |
R897 |
T1623 |
T1622 |
pobj |
RanBP2,of |
R898 |
T1624 |
T1625 |
punct |
[,20 |
R899 |
T1625 |
T1619 |
parataxis |
20,ubiquitination |
R900 |
T1626 |
T1625 |
punct |
],20 |
R901 |
T1627 |
T1617 |
punct |
", ",promotes |
R902 |
T1628 |
T1629 |
advmod |
possibly,via |
R903 |
T1629 |
T1617 |
prep |
via,promotes |
R904 |
T1630 |
T1631 |
det |
the,interaction |
R905 |
T1631 |
T1629 |
pobj |
interaction,via |
R906 |
T1632 |
T1631 |
prep |
of,interaction |
R907 |
T1633 |
T1634 |
det |
the,domain |
R908 |
T1634 |
T1632 |
pobj |
domain,of |
R909 |
T1635 |
T1634 |
compound |
CLD,domain |
R910 |
T1636 |
T1634 |
prep |
of,domain |
R911 |
T1637 |
T1636 |
pobj |
RanBP2,of |
R912 |
T1638 |
T1631 |
prep |
with,interaction |
R913 |
T1639 |
T1640 |
det |
the,subunits |
R914 |
T1640 |
T1638 |
pobj |
subunits,with |
R915 |
T1641 |
T1642 |
compound |
19S,cap |
R916 |
T1642 |
T1640 |
compound |
cap,subunits |
R917 |
T1643 |
T1640 |
prep |
of,subunits |
R918 |
T1644 |
T1645 |
det |
the,proteasome |
R919 |
T1645 |
T1643 |
pobj |
proteasome,of |
R920 |
T1646 |
T1647 |
punct |
[,14 |
R921 |
T1647 |
T1631 |
parataxis |
14,interaction |
R922 |
T1648 |
T1647 |
punct |
],14 |
R923 |
T1649 |
T1617 |
punct |
.,promotes |
R924 |
T1651 |
T1652 |
advmod |
Interestingly,required |
R925 |
T1653 |
T1652 |
punct |
", ",required |
R926 |
T1654 |
T1655 |
det |
the,protein |
R927 |
T1655 |
T1652 |
nsubjpass |
protein,required |
R928 |
T1656 |
T1655 |
amod |
small,protein |
R929 |
T1657 |
T1655 |
nmod |
yeast,protein |
R930 |
T1658 |
T1659 |
npadvmod |
Ran,binding |
R931 |
T1659 |
T1655 |
amod |
binding,protein |
R932 |
T1660 |
T1659 |
punct |
-,binding |
R933 |
T1661 |
T1655 |
nummod |
1,protein |
R934 |
T1662 |
T1655 |
punct |
(,protein |
R935 |
T1663 |
T1655 |
appos |
RanBP1,protein |
R936 |
T1664 |
T1655 |
punct |
),protein |
R937 |
T1665 |
T1655 |
punct |
", ",protein |
R938 |
T1666 |
T1655 |
appos |
Yrb1p,protein |
R939 |
T1667 |
T1655 |
punct |
", ",protein |
R940 |
T1668 |
T1655 |
prep |
with,protein |
R941 |
T1669 |
T1670 |
amod |
strong,homology |
R942 |
T1670 |
T1668 |
pobj |
homology,with |
R943 |
T1671 |
T1670 |
prep |
to,homology |
R944 |
T1672 |
T1673 |
det |
the,domains |
R945 |
T1673 |
T1671 |
pobj |
domains,to |
R946 |
T1674 |
T1675 |
npadvmod |
Ran,binding |
R947 |
T1675 |
T1673 |
amod |
binding,domains |
R948 |
T1676 |
T1675 |
punct |
-,binding |
R949 |
T1677 |
T1673 |
prep |
of,domains |
R950 |
T1678 |
T1677 |
pobj |
RanBP2,of |
R951 |
T1679 |
T1652 |
punct |
", ",required |
R952 |
T1680 |
T1652 |
auxpass |
is,required |
R953 |
T1681 |
T1652 |
advmod |
also,required |
R954 |
T1682 |
T1652 |
prep |
for,required |
R955 |
T1683 |
T1684 |
compound |
cell,cycle |
R956 |
T1684 |
T1686 |
npadvmod |
cycle,regulated |
R957 |
T1685 |
T1684 |
punct |
-,cycle |
R958 |
T1686 |
T1687 |
amod |
regulated,degradation |
R959 |
T1687 |
T1682 |
pobj |
degradation,for |
R960 |
T1688 |
T1687 |
compound |
protein,degradation |
R961 |
T1689 |
T1690 |
punct |
[,21 |
R962 |
T1690 |
T1652 |
parataxis |
21,required |
R963 |
T1691 |
T1690 |
punct |
],21 |
R964 |
T1692 |
T1652 |
punct |
.,required |
R965 |
T1694 |
T1695 |
nsubj |
Parkin,has |
R966 |
T1696 |
T1694 |
punct |
", ",Parkin |
R967 |
T1697 |
T1694 |
prep |
like,Parkin |
R968 |
T1698 |
T1697 |
pobj |
RanBP2,like |
R969 |
T1699 |
T1700 |
punct |
[,17 |
R970 |
T1700 |
T1694 |
parataxis |
17,Parkin |
R971 |
T1701 |
T1700 |
punct |
],17 |
R972 |
T1702 |
T1695 |
punct |
", ",has |
R973 |
T1703 |
T1704 |
compound |
E3,ligase |
R974 |
T1704 |
T1706 |
compound |
ligase,activity |
R975 |
T1705 |
T1704 |
punct |
-,ligase |
R976 |
T1706 |
T1695 |
dobj |
activity,has |
R977 |
T1707 |
T1708 |
punct |
[,22 |
R978 |
T1708 |
T1695 |
parataxis |
22,has |
R979 |
T1709 |
T1710 |
punct |
–,24 |
R980 |
T1710 |
T1708 |
prep |
24,22 |
R981 |
T1711 |
T1708 |
punct |
],22 |
R982 |
T1712 |
T1695 |
punct |
;,has |
R983 |
T1713 |
T1695 |
cc |
and,has |
R984 |
T1714 |
T1715 |
nsubj |
loss,leads |
R985 |
T1715 |
T1695 |
conj |
leads,has |
R986 |
T1716 |
T1714 |
punct |
-,loss |
R987 |
T1717 |
T1714 |
prep |
of,loss |
R988 |
T1718 |
T1717 |
punct |
-,of |
R989 |
T1719 |
T1717 |
pobj |
function,of |
R990 |
T1720 |
T1714 |
prep |
of,loss |
R991 |
T1721 |
T1720 |
pobj |
parkin,of |
R992 |
T1722 |
T1715 |
prep |
to,leads |
R993 |
T1723 |
T1724 |
amod |
early,onset |
R994 |
T1724 |
T1725 |
nmod |
onset,Parkinsonism |
R995 |
T1725 |
T1722 |
pobj |
Parkinsonism,to |
R996 |
T1726 |
T1727 |
amod |
autosomal,recessive |
R997 |
T1727 |
T1725 |
amod |
recessive,Parkinsonism |
R998 |
T1728 |
T1725 |
amod |
juvenile,Parkinsonism |
R999 |
T1729 |
T1730 |
punct |
[,25 |