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PMC:1626108 / 3465-7769 JSONTXT 5 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T1039 13-16 DT denotes The
T1041 17-23 NN denotes RanBP2
T1042 23-24 HYPH denotes /
T1040 24-30 NN denotes Nup358
T1043 31-33 VBZ denotes is
T1044 34-35 DT denotes a
T1046 36-42 JJ denotes unique
T1047 43-53 NN denotes vertebrate
T1048 54-57 CC denotes and
T1049 58-63 JJ denotes large
T1050 64-72 NN denotes scaffold
T1045 73-80 NN denotes protein
T1051 81-90 VBN denotes comprised
T1052 91-93 IN denotes of
T1053 94-102 JJ denotes multiple
T1055 103-113 JJ denotes structural
T1056 114-117 CC denotes and
T1057 118-128 JJ denotes functional
T1054 129-136 NNS denotes domains
T1058 137-138 -LRB- denotes [
T1059 138-139 CD denotes 1
T1060 139-140 SYM denotes –
T1061 140-141 CD denotes 4
T1062 141-142 -RRB- denotes ]
T1063 142-143 . denotes .
T1064 143-478 sentence denotes Several roles of RanBP2 have emerged that implicate RanBP2 in nucleocytoplasmic trafficking [3,5], protein biogenesis [6,7], the formation of the mitotic spindle, assembly of the nuclear envelope [8], and the integration of the nuclear envelope breakdown with kinetochore formation and maturation during early mitotic progression [9].
T1065 144-151 JJ denotes Several
T1066 152-157 NNS denotes roles
T1068 158-160 IN denotes of
T1069 161-167 NN denotes RanBP2
T1070 168-172 VBP denotes have
T1067 173-180 VBN denotes emerged
T1071 181-185 WDT denotes that
T1072 186-195 VBP denotes implicate
T1073 196-202 NN denotes RanBP2
T1074 203-205 IN denotes in
T1075 206-223 JJ denotes nucleocytoplasmic
T1076 224-235 NN denotes trafficking
T1077 236-237 -LRB- denotes [
T1079 237-238 CD denotes 3
T1080 238-239 , denotes ,
T1078 239-240 CD denotes 5
T1081 240-241 -RRB- denotes ]
T1082 241-243 , denotes ,
T1083 243-250 NN denotes protein
T1084 251-261 NN denotes biogenesis
T1085 262-263 -LRB- denotes [
T1087 263-264 CD denotes 6
T1088 264-265 , denotes ,
T1086 265-266 CD denotes 7
T1089 266-267 -RRB- denotes ]
T1090 267-269 , denotes ,
T1091 269-272 DT denotes the
T1092 273-282 NN denotes formation
T1093 283-285 IN denotes of
T1094 286-289 DT denotes the
T1096 290-297 JJ denotes mitotic
T1095 298-305 NN denotes spindle
T1097 305-307 , denotes ,
T1098 307-315 NN denotes assembly
T1099 316-318 IN denotes of
T1100 319-322 DT denotes the
T1102 323-330 JJ denotes nuclear
T1101 331-339 NN denotes envelope
T1103 340-341 -LRB- denotes [
T1104 341-342 CD denotes 8
T1105 342-343 -RRB- denotes ]
T1106 343-345 , denotes ,
T1107 345-348 CC denotes and
T1108 349-352 DT denotes the
T1109 353-364 NN denotes integration
T1110 365-367 IN denotes of
T1111 368-371 DT denotes the
T1113 372-379 JJ denotes nuclear
T1114 380-388 NN denotes envelope
T1112 389-398 NN denotes breakdown
T1115 399-403 IN denotes with
T1116 404-415 NN denotes kinetochore
T1117 416-425 NN denotes formation
T1118 426-429 CC denotes and
T1119 430-440 NN denotes maturation
T1120 441-447 IN denotes during
T1121 448-453 JJ denotes early
T1123 454-461 JJ denotes mitotic
T1122 462-473 NN denotes progression
T1124 474-475 -LRB- denotes [
T1125 475-476 CD denotes 9
T1126 476-477 -RRB- denotes ]
T1127 477-478 . denotes .
T1128 478-662 sentence denotes The specific interaction of RanBP2 with a diverse set of partners likely reflects a pleiotropic role of RanBP2 in cell function, possibly through the integration of multiple pathways.
T1129 479-482 DT denotes The
T1131 483-491 JJ denotes specific
T1130 492-503 NN denotes interaction
T1133 504-506 IN denotes of
T1134 507-513 NN denotes RanBP2
T1135 514-518 IN denotes with
T1136 519-520 DT denotes a
T1138 521-528 JJ denotes diverse
T1137 529-532 NN denotes set
T1139 533-535 IN denotes of
T1140 536-544 NNS denotes partners
T1141 545-551 RB denotes likely
T1132 552-560 VBZ denotes reflects
T1142 561-562 DT denotes a
T1144 563-574 JJ denotes pleiotropic
T1143 575-579 NN denotes role
T1145 580-582 IN denotes of
T1146 583-589 NN denotes RanBP2
T1147 590-592 IN denotes in
T1148 593-597 NN denotes cell
T1149 598-606 NN denotes function
T1150 606-608 , denotes ,
T1151 608-616 RB denotes possibly
T1152 617-624 IN denotes through
T1153 625-628 DT denotes the
T1154 629-640 NN denotes integration
T1155 641-643 IN denotes of
T1156 644-652 JJ denotes multiple
T1157 653-661 NNS denotes pathways
T1158 661-662 . denotes .
T1159 662-806 sentence denotes On the other hand, the cell (tissue)-selective interaction of RanBP2 with some of its partners may also impart cell-restricted roles to RanBP2.
T1160 663-665 IN denotes On
T1162 666-669 DT denotes the
T1164 670-675 JJ denotes other
T1163 676-680 NN denotes hand
T1165 680-682 , denotes ,
T1166 682-685 DT denotes the
T1168 686-690 NN denotes cell
T1170 691-692 -LRB- denotes (
T1171 692-698 NN denotes tissue
T1172 698-699 -RRB- denotes )
T1173 699-700 HYPH denotes -
T1169 700-709 JJ denotes selective
T1167 710-721 NN denotes interaction
T1174 722-724 IN denotes of
T1175 725-731 NN denotes RanBP2
T1176 732-736 IN denotes with
T1177 737-741 DT denotes some
T1178 742-744 IN denotes of
T1179 745-748 PRP$ denotes its
T1180 749-757 NNS denotes partners
T1181 758-761 MD denotes may
T1182 762-766 RB denotes also
T1161 767-773 VB denotes impart
T1183 774-778 NN denotes cell
T1185 778-779 HYPH denotes -
T1184 779-789 JJ denotes restricted
T1186 790-795 NNS denotes roles
T1187 796-798 IN denotes to
T1188 799-805 NN denotes RanBP2
T1189 805-806 . denotes .
T1190 806-1072 sentence denotes For example, the Ran-binding domains RBDn=1-4 of RanBP2 associate with the nuclear import co-receptor, importin-β [10,11], and antibodies against RanBP2 inhibit the nuclear import pathway in HeLa cells [3]; but such a role seems dispensable in Xenopus oocytes [12].
T1191 807-810 IN denotes For
T1193 811-818 NN denotes example
T1194 818-820 , denotes ,
T1195 820-823 DT denotes the
T1197 824-827 NN denotes Ran
T1199 827-828 HYPH denotes -
T1198 828-835 VBG denotes binding
T1196 836-843 NNS denotes domains
T1200 844-848 NN denotes RBDn
T1202 848-849 SYM denotes =
T1201 849-850 CD denotes 1
T1203 850-851 SYM denotes -
T1204 851-852 CD denotes 4
T1205 853-855 IN denotes of
T1206 856-862 NN denotes RanBP2
T1192 863-872 VBP denotes associate
T1207 873-877 IN denotes with
T1208 878-881 DT denotes the
T1210 882-889 JJ denotes nuclear
T1211 890-896 NN denotes import
T1209 897-908 NN denotes co-receptor
T1212 908-910 , denotes ,
T1213 910-918 NN denotes importin
T1215 918-919 HYPH denotes -
T1214 919-920 NN denotes β
T1216 921-922 -LRB- denotes [
T1218 922-924 CD denotes 10
T1219 924-925 , denotes ,
T1217 925-927 CD denotes 11
T1220 927-928 -RRB- denotes ]
T1221 928-930 , denotes ,
T1222 930-933 CC denotes and
T1223 934-944 NNS denotes antibodies
T1225 945-952 IN denotes against
T1226 953-959 NN denotes RanBP2
T1224 960-967 VBP denotes inhibit
T1227 968-971 DT denotes the
T1229 972-979 JJ denotes nuclear
T1230 980-986 NN denotes import
T1228 987-994 NN denotes pathway
T1231 995-997 IN denotes in
T1232 998-1002 NN denotes HeLa
T1233 1003-1008 NNS denotes cells
T1234 1009-1010 -LRB- denotes [
T1235 1010-1011 CD denotes 3
T1236 1011-1012 -RRB- denotes ]
T1237 1012-1013 : denotes ;
T1238 1014-1017 CC denotes but
T1239 1018-1022 PDT denotes such
T1241 1023-1024 DT denotes a
T1240 1025-1029 NN denotes role
T1242 1030-1035 VBZ denotes seems
T1243 1036-1047 JJ denotes dispensable
T1244 1048-1050 IN denotes in
T1245 1051-1058 NN denotes Xenopus
T1246 1059-1066 NNS denotes oocytes
T1247 1067-1068 -LRB- denotes [
T1248 1068-1070 CD denotes 12
T1249 1070-1071 -RRB- denotes ]
T1250 1071-1072 . denotes .
T1251 1072-1516 sentence denotes In addition, the combination of the C-terminal domains, RBD4 and CY (of RanBP2), associates with a subset of G protein-coupled receptors, the red/green opsin, expressed in photosensory neurons and enhances opsin functional production [6,7], while the interaction of the KBD of RanBP2 with a subset of the conventional microtubule-based motor proteins, the kinesins, KIF5B and KIF5C, occurs selectively in the central nervous system (CNS) [13].
T1252 1073-1075 IN denotes In
T1254 1076-1084 NN denotes addition
T1255 1084-1086 , denotes ,
T1256 1086-1089 DT denotes the
T1257 1090-1101 NN denotes combination
T1258 1102-1104 IN denotes of
T1259 1105-1108 DT denotes the
T1261 1109-1110 NN denotes C
T1263 1110-1111 HYPH denotes -
T1262 1111-1119 JJ denotes terminal
T1260 1120-1127 NNS denotes domains
T1264 1127-1129 , denotes ,
T1265 1129-1133 NN denotes RBD4
T1266 1134-1137 CC denotes and
T1267 1138-1140 NN denotes CY
T1268 1141-1142 -LRB- denotes (
T1269 1142-1144 IN denotes of
T1270 1145-1151 NN denotes RanBP2
T1271 1151-1152 -RRB- denotes )
T1272 1152-1154 , denotes ,
T1253 1154-1164 VBZ denotes associates
T1273 1165-1169 IN denotes with
T1274 1170-1171 DT denotes a
T1275 1172-1178 NN denotes subset
T1276 1179-1181 IN denotes of
T1277 1182-1183 NN denotes G
T1278 1184-1191 NN denotes protein
T1280 1191-1192 HYPH denotes -
T1279 1192-1199 VBN denotes coupled
T1281 1200-1209 NNS denotes receptors
T1282 1209-1211 , denotes ,
T1283 1211-1214 DT denotes the
T1285 1215-1218 JJ denotes red
T1287 1218-1219 HYPH denotes /
T1286 1219-1224 JJ denotes green
T1284 1225-1230 NN denotes opsin
T1288 1230-1232 , denotes ,
T1289 1232-1241 VBN denotes expressed
T1290 1242-1244 IN denotes in
T1291 1245-1257 JJ denotes photosensory
T1292 1258-1265 NNS denotes neurons
T1293 1266-1269 CC denotes and
T1294 1270-1278 VBZ denotes enhances
T1295 1279-1284 NN denotes opsin
T1297 1285-1295 JJ denotes functional
T1296 1296-1306 NN denotes production
T1298 1307-1308 -LRB- denotes [
T1300 1308-1309 CD denotes 6
T1301 1309-1310 , denotes ,
T1299 1310-1311 CD denotes 7
T1302 1311-1312 -RRB- denotes ]
T1303 1312-1314 , denotes ,
T1304 1314-1319 IN denotes while
T1306 1320-1323 DT denotes the
T1307 1324-1335 NN denotes interaction
T1308 1336-1338 IN denotes of
T1309 1339-1342 DT denotes the
T1310 1343-1346 NN denotes KBD
T1311 1347-1349 IN denotes of
T1312 1350-1356 NN denotes RanBP2
T1313 1357-1361 IN denotes with
T1314 1362-1363 DT denotes a
T1315 1364-1370 NN denotes subset
T1316 1371-1373 IN denotes of
T1317 1374-1377 DT denotes the
T1319 1378-1390 JJ denotes conventional
T1320 1391-1402 NN denotes microtubule
T1322 1402-1403 HYPH denotes -
T1321 1403-1408 VBN denotes based
T1323 1409-1414 NN denotes motor
T1318 1415-1423 NN denotes proteins
T1324 1423-1425 , denotes ,
T1325 1425-1428 DT denotes the
T1326 1429-1437 NNS denotes kinesins
T1327 1437-1439 , denotes ,
T1328 1439-1444 NN denotes KIF5B
T1329 1445-1448 CC denotes and
T1330 1449-1454 NN denotes KIF5C
T1331 1454-1456 , denotes ,
T1305 1456-1462 VBZ denotes occurs
T1332 1463-1474 RB denotes selectively
T1333 1475-1477 IN denotes in
T1334 1478-1481 DT denotes the
T1336 1482-1489 JJ denotes central
T1337 1490-1497 JJ denotes nervous
T1335 1498-1504 NN denotes system
T1338 1505-1506 -LRB- denotes (
T1339 1506-1509 NN denotes CNS
T1340 1509-1510 -RRB- denotes )
T1341 1511-1512 -LRB- denotes [
T1342 1512-1514 CD denotes 13
T1343 1514-1515 -RRB- denotes ]
T1344 1515-1516 . denotes .
T1345 1516-1692 sentence denotes A diverse set of additional molecular partners, each associating specifically with a selective domain of RanBP2, are likely to impart and integrate additional roles to RanBP2.
T1346 1517-1518 DT denotes A
T1348 1519-1526 JJ denotes diverse
T1347 1527-1530 NN denotes set
T1350 1531-1533 IN denotes of
T1351 1534-1544 JJ denotes additional
T1353 1545-1554 JJ denotes molecular
T1352 1555-1563 NNS denotes partners
T1354 1563-1565 , denotes ,
T1355 1565-1569 RB denotes each
T1356 1570-1581 VBG denotes associating
T1357 1582-1594 RB denotes specifically
T1358 1595-1599 IN denotes with
T1359 1600-1601 DT denotes a
T1361 1602-1611 JJ denotes selective
T1360 1612-1618 NN denotes domain
T1362 1619-1621 IN denotes of
T1363 1622-1628 NN denotes RanBP2
T1364 1628-1630 , denotes ,
T1349 1630-1633 VBP denotes are
T1365 1634-1640 JJ denotes likely
T1366 1641-1643 TO denotes to
T1367 1644-1650 VB denotes impart
T1368 1651-1654 CC denotes and
T1369 1655-1664 VB denotes integrate
T1370 1665-1675 JJ denotes additional
T1371 1676-1681 NNS denotes roles
T1372 1682-1684 IN denotes to
T1373 1685-1691 NN denotes RanBP2
T1374 1691-1692 . denotes .
T1375 1692-2009 sentence denotes For example, the cyclophilin-like domain (CLD), the internal repeat (W1W2/IR), and zinc-finger rich (ZnF) domains of RanBP2 associate specifically with components of the 19S cap of the proteasome [14], the E2 SUMO-1-conjugating enzyme (Ubc9) [15], and the nuclear export receptor, CRM1/exportin-1 [16], respectively.
T1376 1693-1696 IN denotes For
T1378 1697-1704 NN denotes example
T1379 1704-1706 , denotes ,
T1380 1706-1709 DT denotes the
T1382 1710-1721 NN denotes cyclophilin
T1384 1721-1722 HYPH denotes -
T1383 1722-1726 JJ denotes like
T1381 1727-1733 NN denotes domain
T1385 1734-1735 -LRB- denotes (
T1386 1735-1738 NN denotes CLD
T1387 1738-1739 -RRB- denotes )
T1388 1739-1741 , denotes ,
T1389 1741-1744 DT denotes the
T1391 1745-1753 JJ denotes internal
T1392 1754-1760 NN denotes repeat
T1393 1761-1762 -LRB- denotes (
T1395 1762-1766 NN denotes W1W2
T1396 1766-1767 HYPH denotes /
T1394 1767-1769 NN denotes IR
T1397 1769-1770 -RRB- denotes )
T1398 1770-1772 , denotes ,
T1399 1772-1775 CC denotes and
T1400 1776-1780 NN denotes zinc
T1402 1780-1781 HYPH denotes -
T1401 1781-1787 NN denotes finger
T1403 1788-1792 JJ denotes rich
T1404 1793-1794 -LRB- denotes (
T1405 1794-1797 NN denotes ZnF
T1406 1797-1798 -RRB- denotes )
T1390 1799-1806 NNS denotes domains
T1407 1807-1809 IN denotes of
T1408 1810-1816 NN denotes RanBP2
T1377 1817-1826 VBP denotes associate
T1409 1827-1839 RB denotes specifically
T1410 1840-1844 IN denotes with
T1411 1845-1855 NNS denotes components
T1412 1856-1858 IN denotes of
T1413 1859-1862 DT denotes the
T1415 1863-1866 NN denotes 19S
T1414 1867-1870 NN denotes cap
T1416 1871-1873 IN denotes of
T1417 1874-1877 DT denotes the
T1418 1878-1888 NN denotes proteasome
T1419 1889-1890 -LRB- denotes [
T1420 1890-1892 CD denotes 14
T1421 1892-1893 -RRB- denotes ]
T1422 1893-1895 , denotes ,
T1423 1895-1898 DT denotes the
T1425 1899-1901 NN denotes E2
T1426 1902-1906 NN denotes SUMO
T1428 1906-1907 HYPH denotes -
T1429 1907-1908 CD denotes 1
T1430 1908-1909 HYPH denotes -
T1427 1909-1920 VBG denotes conjugating
T1424 1921-1927 NN denotes enzyme
T1431 1928-1929 -LRB- denotes (
T1432 1929-1933 NN denotes Ubc9
T1433 1933-1934 -RRB- denotes )
T1434 1935-1936 -LRB- denotes [
T1435 1936-1938 CD denotes 15
T1436 1938-1939 -RRB- denotes ]
T1437 1939-1941 , denotes ,
T1438 1941-1944 CC denotes and
T1439 1945-1948 DT denotes the
T1441 1949-1956 JJ denotes nuclear
T1442 1957-1963 NN denotes export
T1440 1964-1972 NN denotes receptor
T1443 1972-1974 , denotes ,
T1444 1974-1978 NN denotes CRM1
T1446 1978-1979 HYPH denotes /
T1445 1979-1987 NN denotes exportin
T1447 1987-1988 HYPH denotes -
T1448 1988-1989 CD denotes 1
T1449 1990-1991 -LRB- denotes [
T1450 1991-1993 CD denotes 16
T1451 1993-1994 -RRB- denotes ]
T1452 1994-1996 , denotes ,
T1453 1996-2008 RB denotes respectively
T1454 2008-2009 . denotes .
T1455 2009-2291 sentence denotes RanBP2 itself was also found to exhibit SUMO1 E3 ligase activity [17], supporting a direct link between RanBP2-mediated SUMO-1 substrate modification and relocation of SUMO-1 modified cytosolic substrates (e.g., RanGAP) to the cytosolic face of the nuclear pore complex (NPC) [18].
T1456 2010-2016 NN denotes RanBP2
T1458 2017-2023 PRP denotes itself
T1459 2024-2027 VBD denotes was
T1460 2028-2032 RB denotes also
T1457 2033-2038 VBN denotes found
T1461 2039-2041 TO denotes to
T1462 2042-2049 VB denotes exhibit
T1463 2050-2055 NN denotes SUMO1
T1465 2056-2058 NN denotes E3
T1464 2059-2065 NN denotes ligase
T1466 2066-2074 NN denotes activity
T1467 2075-2076 -LRB- denotes [
T1468 2076-2078 CD denotes 17
T1469 2078-2079 -RRB- denotes ]
T1470 2079-2081 , denotes ,
T1471 2081-2091 VBG denotes supporting
T1472 2092-2093 DT denotes a
T1474 2094-2100 JJ denotes direct
T1473 2101-2105 NN denotes link
T1475 2106-2113 IN denotes between
T1476 2114-2120 NN denotes RanBP2
T1478 2120-2121 HYPH denotes -
T1477 2121-2129 JJ denotes mediated
T1480 2130-2134 NN denotes SUMO
T1482 2134-2135 HYPH denotes -
T1483 2135-2136 CD denotes 1
T1481 2137-2146 NN denotes substrate
T1479 2147-2159 NN denotes modification
T1484 2160-2163 CC denotes and
T1485 2164-2174 NN denotes relocation
T1486 2175-2177 IN denotes of
T1487 2178-2182 NN denotes SUMO
T1489 2182-2183 HYPH denotes -
T1490 2183-2184 CD denotes 1
T1488 2185-2193 VBN denotes modified
T1492 2194-2203 JJ denotes cytosolic
T1491 2204-2214 NNS denotes substrates
T1493 2215-2216 -LRB- denotes (
T1494 2216-2220 FW denotes e.g.
T1496 2220-2222 , denotes ,
T1495 2222-2228 NN denotes RanGAP
T1497 2228-2229 -RRB- denotes )
T1498 2230-2232 IN denotes to
T1499 2233-2236 DT denotes the
T1501 2237-2246 JJ denotes cytosolic
T1500 2247-2251 NN denotes face
T1502 2252-2254 IN denotes of
T1503 2255-2258 DT denotes the
T1505 2259-2266 JJ denotes nuclear
T1506 2267-2271 NN denotes pore
T1504 2272-2279 NN denotes complex
T1507 2280-2281 -LRB- denotes (
T1508 2281-2284 NN denotes NPC
T1509 2284-2285 -RRB- denotes )
T1510 2286-2287 -LRB- denotes [
T1511 2287-2289 CD denotes 18
T1512 2289-2290 -RRB- denotes ]
T1513 2290-2291 . denotes .
T1514 2291-2598 sentence denotes Finally, RanBP2 was also found to localize prominently to the mitochondria-rich ellipsoid subcellular compartment of photosensory neurons [19] and to RanGTPase-restricted foci along cytoplasmic tracks [19], in addition to its localization at cytoplasmic fibrils emanating from nuclear pores [2,3,10,12,19].
T1515 2292-2299 RB denotes Finally
T1517 2299-2301 , denotes ,
T1518 2301-2307 NN denotes RanBP2
T1519 2308-2311 VBD denotes was
T1520 2312-2316 RB denotes also
T1516 2317-2322 VBN denotes found
T1521 2323-2325 TO denotes to
T1522 2326-2334 VB denotes localize
T1523 2335-2346 RB denotes prominently
T1524 2347-2349 IN denotes to
T1525 2350-2353 DT denotes the
T1527 2354-2366 NNS denotes mitochondria
T1529 2366-2367 HYPH denotes -
T1528 2367-2371 JJ denotes rich
T1530 2372-2381 JJ denotes ellipsoid
T1531 2382-2393 JJ denotes subcellular
T1526 2394-2405 NN denotes compartment
T1532 2406-2408 IN denotes of
T1533 2409-2421 JJ denotes photosensory
T1534 2422-2429 NNS denotes neurons
T1535 2430-2431 -LRB- denotes [
T1536 2431-2433 CD denotes 19
T1537 2433-2434 -RRB- denotes ]
T1538 2435-2438 CC denotes and
T1539 2439-2441 IN denotes to
T1540 2442-2451 NN denotes RanGTPase
T1542 2451-2452 HYPH denotes -
T1541 2452-2462 VBN denotes restricted
T1543 2463-2467 NNS denotes foci
T1544 2468-2473 IN denotes along
T1545 2474-2485 JJ denotes cytoplasmic
T1546 2486-2492 NNS denotes tracks
T1547 2493-2494 -LRB- denotes [
T1548 2494-2496 CD denotes 19
T1549 2496-2497 -RRB- denotes ]
T1550 2497-2499 , denotes ,
T1551 2499-2501 IN denotes in
T1552 2502-2510 NN denotes addition
T1553 2511-2513 IN denotes to
T1554 2514-2517 PRP$ denotes its
T1555 2518-2530 NN denotes localization
T1556 2531-2533 IN denotes at
T1557 2534-2545 JJ denotes cytoplasmic
T1558 2546-2553 NNS denotes fibrils
T1559 2554-2563 VBG denotes emanating
T1560 2564-2568 IN denotes from
T1561 2569-2576 JJ denotes nuclear
T1562 2577-2582 NNS denotes pores
T1563 2583-2584 -LRB- denotes [
T1565 2584-2585 CD denotes 2
T1566 2585-2586 , denotes ,
T1567 2586-2587 CD denotes 3
T1568 2587-2588 , denotes ,
T1569 2588-2590 CD denotes 10
T1570 2590-2591 , denotes ,
T1571 2591-2593 CD denotes 12
T1572 2593-2594 , denotes ,
T1564 2594-2596 CD denotes 19
T1573 2596-2597 -RRB- denotes ]
T1574 2597-2598 . denotes .
T1575 2598-2726 sentence denotes Emerging evidence supports that the CNS-selective effects of RanBP2 may also underlie the pathogenesis of certain neuropathies.
T1576 2599-2607 VBG denotes Emerging
T1577 2608-2616 NN denotes evidence
T1578 2617-2625 VBZ denotes supports
T1579 2626-2630 IN denotes that
T1581 2631-2634 DT denotes the
T1583 2635-2638 NN denotes CNS
T1585 2638-2639 HYPH denotes -
T1584 2639-2648 JJ denotes selective
T1582 2649-2656 NNS denotes effects
T1586 2657-2659 IN denotes of
T1587 2660-2666 NN denotes RanBP2
T1588 2667-2670 MD denotes may
T1589 2671-2675 RB denotes also
T1580 2676-2684 VB denotes underlie
T1590 2685-2688 DT denotes the
T1591 2689-2701 NN denotes pathogenesis
T1592 2702-2704 IN denotes of
T1593 2705-2712 JJ denotes certain
T1594 2713-2725 NNS denotes neuropathies
T1595 2725-2726 . denotes .
T1596 2726-2822 sentence denotes Parkin is ubiquitously expressed and interacts with the Ubc9-interacting domain of RanBP2 [20].
T1597 2727-2733 NN denotes Parkin
T1599 2734-2736 VBZ denotes is
T1600 2737-2749 RB denotes ubiquitously
T1598 2750-2759 VBN denotes expressed
T1601 2760-2763 CC denotes and
T1602 2764-2773 VBZ denotes interacts
T1603 2774-2778 IN denotes with
T1604 2779-2782 DT denotes the
T1606 2783-2787 NN denotes Ubc9
T1608 2787-2788 HYPH denotes -
T1607 2788-2799 VBG denotes interacting
T1605 2800-2806 NN denotes domain
T1609 2807-2809 IN denotes of
T1610 2810-2816 NN denotes RanBP2
T1611 2817-2818 -LRB- denotes [
T1612 2818-2820 CD denotes 20
T1613 2820-2821 -RRB- denotes ]
T1614 2821-2822 . denotes .
T1615 2822-2994 sentence denotes This promotes the ubiquitination and degradation of RanBP2 [20], possibly via the interaction of the CLD domain of RanBP2 with the 19S cap subunits of the proteasome [14].
T1616 2823-2827 DT denotes This
T1617 2828-2836 VBZ denotes promotes
T1618 2837-2840 DT denotes the
T1619 2841-2855 NN denotes ubiquitination
T1620 2856-2859 CC denotes and
T1621 2860-2871 NN denotes degradation
T1622 2872-2874 IN denotes of
T1623 2875-2881 NN denotes RanBP2
T1624 2882-2883 -LRB- denotes [
T1625 2883-2885 CD denotes 20
T1626 2885-2886 -RRB- denotes ]
T1627 2886-2888 , denotes ,
T1628 2888-2896 RB denotes possibly
T1629 2897-2900 IN denotes via
T1630 2901-2904 DT denotes the
T1631 2905-2916 NN denotes interaction
T1632 2917-2919 IN denotes of
T1633 2920-2923 DT denotes the
T1635 2924-2927 NN denotes CLD
T1634 2928-2934 NN denotes domain
T1636 2935-2937 IN denotes of
T1637 2938-2944 NN denotes RanBP2
T1638 2945-2949 IN denotes with
T1639 2950-2953 DT denotes the
T1641 2954-2957 NN denotes 19S
T1642 2958-2961 NN denotes cap
T1640 2962-2970 NNS denotes subunits
T1643 2971-2973 IN denotes of
T1644 2974-2977 DT denotes the
T1645 2978-2988 NN denotes proteasome
T1646 2989-2990 -LRB- denotes [
T1647 2990-2992 CD denotes 14
T1648 2992-2993 -RRB- denotes ]
T1649 2993-2994 . denotes .
T1650 2994-3191 sentence denotes Interestingly, the small yeast Ran-binding protein 1 (RanBP1), Yrb1p, with strong homology to the Ran-binding domains of RanBP2, is also required for cell-cycle regulated protein degradation [21].
T1651 2995-3008 RB denotes Interestingly
T1653 3008-3010 , denotes ,
T1654 3010-3013 DT denotes the
T1656 3014-3019 JJ denotes small
T1657 3020-3025 NN denotes yeast
T1658 3026-3029 NN denotes Ran
T1660 3029-3030 HYPH denotes -
T1659 3030-3037 VBG denotes binding
T1655 3038-3045 NN denotes protein
T1661 3046-3047 CD denotes 1
T1662 3048-3049 -LRB- denotes (
T1663 3049-3055 NN denotes RanBP1
T1664 3055-3056 -RRB- denotes )
T1665 3056-3058 , denotes ,
T1666 3058-3063 NN denotes Yrb1p
T1667 3063-3065 , denotes ,
T1668 3065-3069 IN denotes with
T1669 3070-3076 JJ denotes strong
T1670 3077-3085 NN denotes homology
T1671 3086-3088 IN denotes to
T1672 3089-3092 DT denotes the
T1674 3093-3096 NN denotes Ran
T1676 3096-3097 HYPH denotes -
T1675 3097-3104 VBG denotes binding
T1673 3105-3112 NNS denotes domains
T1677 3113-3115 IN denotes of
T1678 3116-3122 NN denotes RanBP2
T1679 3122-3124 , denotes ,
T1680 3124-3126 VBZ denotes is
T1681 3127-3131 RB denotes also
T1652 3132-3140 VBN denotes required
T1682 3141-3144 IN denotes for
T1683 3145-3149 NN denotes cell
T1685 3149-3150 HYPH denotes -
T1684 3150-3155 NN denotes cycle
T1686 3156-3165 VBN denotes regulated
T1688 3166-3173 NN denotes protein
T1687 3174-3185 NN denotes degradation
T1689 3186-3187 -LRB- denotes [
T1690 3187-3189 CD denotes 21
T1691 3189-3190 -RRB- denotes ]
T1692 3190-3191 . denotes .
T1693 3191-3349 sentence denotes Parkin, like RanBP2 [17], has E3-ligase activity [22–24]; and loss-of-function of parkin leads to early onset autosomal recessive juvenile Parkinsonism [25].
T1694 3192-3198 NN denotes Parkin
T1696 3198-3200 , denotes ,
T1697 3200-3204 IN denotes like
T1698 3205-3211 NN denotes RanBP2
T1699 3212-3213 -LRB- denotes [
T1700 3213-3215 CD denotes 17
T1701 3215-3216 -RRB- denotes ]
T1702 3216-3218 , denotes ,
T1695 3218-3221 VBZ denotes has
T1703 3222-3224 NN denotes E3
T1705 3224-3225 HYPH denotes -
T1704 3225-3231 NN denotes ligase
T1706 3232-3240 NN denotes activity
T1707 3241-3242 -LRB- denotes [
T1708 3242-3244 CD denotes 22
T1709 3244-3245 SYM denotes –
T1710 3245-3247 CD denotes 24
T1711 3247-3248 -RRB- denotes ]
T1712 3248-3249 : denotes ;
T1713 3250-3253 CC denotes and
T1714 3254-3258 NN denotes loss
T1716 3258-3259 HYPH denotes -
T1717 3259-3261 IN denotes of
T1718 3261-3262 HYPH denotes -
T1719 3262-3270 NN denotes function
T1720 3271-3273 IN denotes of
T1721 3274-3280 NN denotes parkin
T1715 3281-3286 VBZ denotes leads
T1722 3287-3289 IN denotes to
T1723 3290-3295 JJ denotes early
T1724 3296-3301 NN denotes onset
T1726 3302-3311 JJ denotes autosomal
T1727 3312-3321 JJ denotes recessive
T1728 3322-3330 JJ denotes juvenile
T1725 3331-3343 NN denotes Parkinsonism
T1729 3344-3345 -LRB- denotes [
T1730 3345-3347 CD denotes 25
T1731 3347-3348 -RRB- denotes ]
T1732 3348-3349 . denotes .
T1733 3349-3769 sentence denotes While the dopaminergic neuronal-restricted effects of mutations in parkin are not understood [25], parkin−/− mice exhibit mitochondrial dysfunction and energy and growth deficits, and a fraction of parkin localizes to the cytoplasmic face of the mitochondria, where together with other partners is thought to promote the degradation of selective mitochondrial substrates and to exert a neuroprotective function [26–29].
T1734 3350-3355 IN denotes While
T1736 3356-3359 DT denotes the
T1738 3360-3372 JJ denotes dopaminergic
T1739 3373-3381 JJ denotes neuronal
T1741 3381-3382 HYPH denotes -
T1740 3382-3392 VBN denotes restricted
T1737 3393-3400 NNS denotes effects
T1742 3401-3403 IN denotes of
T1743 3404-3413 NNS denotes mutations
T1744 3414-3416 IN denotes in
T1745 3417-3423 NN denotes parkin
T1735 3424-3427 VBP denotes are
T1747 3428-3431 RB denotes not
T1748 3432-3442 JJ denotes understood
T1749 3443-3444 -LRB- denotes [
T1750 3444-3446 CD denotes 25
T1751 3446-3447 -RRB- denotes ]
T1752 3447-3449 , denotes ,
T1753 3449-3455 NN denotes parkin
T1755 3455-3456 SYM denotes −
T1756 3456-3457 HYPH denotes /
T1757 3457-3458 SYM denotes −
T1754 3459-3463 NNS denotes mice
T1746 3464-3471 VBP denotes exhibit
T1758 3472-3485 JJ denotes mitochondrial
T1759 3486-3497 NN denotes dysfunction
T1760 3498-3501 CC denotes and
T1761 3502-3508 NN denotes energy
T1763 3509-3512 CC denotes and
T1764 3513-3519 NN denotes growth
T1762 3520-3528 NNS denotes deficits
T1765 3528-3530 , denotes ,
T1766 3530-3533 CC denotes and
T1767 3534-3535 DT denotes a
T1768 3536-3544 NN denotes fraction
T1770 3545-3547 IN denotes of
T1771 3548-3554 NN denotes parkin
T1769 3555-3564 VBZ denotes localizes
T1772 3565-3567 IN denotes to
T1773 3568-3571 DT denotes the
T1775 3572-3583 JJ denotes cytoplasmic
T1774 3584-3588 NN denotes face
T1776 3589-3591 IN denotes of
T1777 3592-3595 DT denotes the
T1778 3596-3608 NNS denotes mitochondria
T1779 3608-3610 , denotes ,
T1780 3610-3615 WRB denotes where
T1782 3616-3624 RB denotes together
T1783 3625-3629 IN denotes with
T1784 3630-3635 JJ denotes other
T1785 3636-3644 NNS denotes partners
T1786 3645-3647 VBZ denotes is
T1781 3648-3655 VBN denotes thought
T1787 3656-3658 TO denotes to
T1788 3659-3666 VB denotes promote
T1789 3667-3670 DT denotes the
T1790 3671-3682 NN denotes degradation
T1791 3683-3685 IN denotes of
T1792 3686-3695 JJ denotes selective
T1794 3696-3709 JJ denotes mitochondrial
T1793 3710-3720 NNS denotes substrates
T1795 3721-3724 CC denotes and
T1796 3725-3727 TO denotes to
T1797 3728-3733 VB denotes exert
T1798 3734-3735 DT denotes a
T1800 3736-3751 JJ denotes neuroprotective
T1799 3752-3760 NN denotes function
T1801 3761-3762 -LRB- denotes [
T1802 3762-3764 CD denotes 26
T1803 3764-3765 SYM denotes –
T1804 3765-3767 CD denotes 29
T1805 3767-3768 -RRB- denotes ]
T1806 3768-3769 . denotes .
T1807 3769-3907 sentence denotes These data suggest that deficits in RanBP2 and parkin may share (patho) physiological pathways and support a multifaceted role of RanBP2.
T1808 3770-3775 DT denotes These
T1809 3776-3780 NNS denotes data
T1810 3781-3788 VBP denotes suggest
T1811 3789-3793 IN denotes that
T1813 3794-3802 NNS denotes deficits
T1814 3803-3805 IN denotes in
T1815 3806-3812 NN denotes RanBP2
T1816 3813-3816 CC denotes and
T1817 3817-3823 NN denotes parkin
T1818 3824-3827 MD denotes may
T1812 3828-3833 VB denotes share
T1819 3834-3835 -LRB- denotes (
T1821 3835-3840 AFX denotes patho
T1822 3840-3841 -RRB- denotes )
T1820 3842-3855 JJ denotes physiological
T1823 3856-3864 NNS denotes pathways
T1824 3865-3868 CC denotes and
T1825 3869-3876 VB denotes support
T1826 3877-3878 DT denotes a
T1828 3879-3891 JJ denotes multifaceted
T1827 3892-3896 NN denotes role
T1829 3897-3899 IN denotes of
T1830 3900-3906 NN denotes RanBP2
T1831 3906-3907 . denotes .
T1832 3907-3983 sentence denotes Yet clear functions of RanBP2 in animal and cell physiology remain elusive.
T1833 3908-3911 RB denotes Yet
T1835 3912-3917 JJ denotes clear
T1836 3918-3927 NNS denotes functions
T1837 3928-3930 IN denotes of
T1838 3931-3937 NN denotes RanBP2
T1839 3938-3940 IN denotes in
T1840 3941-3947 NN denotes animal
T1842 3948-3951 CC denotes and
T1843 3952-3956 NN denotes cell
T1841 3957-3967 NN denotes physiology
T1834 3968-3974 VBP denotes remain
T1844 3975-3982 JJ denotes elusive
T1845 3982-3983 . denotes .
T1846 3983-4304 sentence denotes Here, we report on the identification and function of two novel partners of RanBP2, Cox11 and hexokinase type I (HKI), which interact with a large and orphan domain of RanBP2, the leucine-rich domain (LD); and on the outcome of partial loss-of-function of RanBP2 on HKI, animal physiology, and glucose/energy metabolism.
T1847 3984-3988 RB denotes Here
T1849 3988-3990 , denotes ,
T1850 3990-3992 PRP denotes we
T1848 3993-3999 VBP denotes report
T1851 4000-4002 IN denotes on
T1852 4003-4006 DT denotes the
T1853 4007-4021 NN denotes identification
T1854 4022-4025 CC denotes and
T1855 4026-4034 NN denotes function
T1856 4035-4037 IN denotes of
T1857 4038-4041 CD denotes two
T1859 4042-4047 JJ denotes novel
T1858 4048-4056 NNS denotes partners
T1860 4057-4059 IN denotes of
T1861 4060-4066 NN denotes RanBP2
T1862 4066-4068 , denotes ,
T1863 4068-4073 NN denotes Cox11
T1864 4074-4077 CC denotes and
T1865 4078-4088 NN denotes hexokinase
T1866 4089-4093 NN denotes type
T1867 4094-4095 CD denotes I
T1868 4096-4097 -LRB- denotes (
T1869 4097-4100 NN denotes HKI
T1870 4100-4101 -RRB- denotes )
T1871 4101-4103 , denotes ,
T1872 4103-4108 WDT denotes which
T1873 4109-4117 VBP denotes interact
T1874 4118-4122 IN denotes with
T1875 4123-4124 DT denotes a
T1877 4125-4130 JJ denotes large
T1878 4131-4134 CC denotes and
T1879 4135-4141 NN denotes orphan
T1876 4142-4148 NN denotes domain
T1880 4149-4151 IN denotes of
T1881 4152-4158 NN denotes RanBP2
T1882 4158-4160 , denotes ,
T1883 4160-4163 DT denotes the
T1885 4164-4171 NN denotes leucine
T1887 4171-4172 HYPH denotes -
T1886 4172-4176 JJ denotes rich
T1884 4177-4183 NN denotes domain
T1888 4184-4185 -LRB- denotes (
T1889 4185-4187 NN denotes LD
T1890 4187-4188 -RRB- denotes )
T1891 4188-4189 : denotes ;
T1892 4190-4193 CC denotes and
T1893 4194-4196 IN denotes on
T1894 4197-4200 DT denotes the
T1895 4201-4208 NN denotes outcome
T1896 4209-4211 IN denotes of
T1897 4212-4219 JJ denotes partial
T1898 4220-4224 NN denotes loss
T1899 4224-4225 HYPH denotes -
T1900 4225-4227 IN denotes of
T1901 4227-4228 HYPH denotes -
T1902 4228-4236 NN denotes function
T1903 4237-4239 IN denotes of
T1904 4240-4246 NN denotes RanBP2
T1905 4247-4249 IN denotes on
T1906 4250-4253 NN denotes HKI
T1907 4253-4255 , denotes ,
T1908 4255-4261 NN denotes animal
T1909 4262-4272 NN denotes physiology
T1910 4272-4274 , denotes ,
T1911 4274-4277 CC denotes and
T1912 4278-4285 NN denotes glucose
T1914 4285-4286 HYPH denotes /
T1913 4286-4292 NN denotes energy
T1915 4293-4303 NN denotes metabolism
T1916 4303-4304 . denotes .
R1000 T1730 T1715 parataxis 25,leads
R1001 T1731 T1730 punct ],25
R1002 T1732 T1715 punct .,leads
R1003 T1734 T1735 mark While,are
R1004 T1735 T1746 advcl are,exhibit
R1005 T1736 T1737 det the,effects
R1006 T1737 T1735 nsubj effects,are
R1007 T1738 T1737 amod dopaminergic,effects
R1008 T1739 T1740 amod neuronal,restricted
R1009 T1740 T1737 amod restricted,effects
R1010 T1741 T1740 punct -,restricted
R1011 T1742 T1737 prep of,effects
R1012 T1743 T1742 pobj mutations,of
R1013 T1744 T1743 prep in,mutations
R1014 T1745 T1744 pobj parkin,in
R1015 T1747 T1735 neg not,are
R1016 T1748 T1735 acomp understood,are
R1017 T1749 T1750 punct [,25
R1018 T1750 T1735 parataxis 25,are
R1019 T1751 T1750 punct ],25
R1020 T1752 T1746 punct ", ",exhibit
R1021 T1753 T1754 nmod parkin,mice
R1022 T1754 T1746 nsubj mice,exhibit
R1023 T1755 T1753 punct −,parkin
R1024 T1756 T1753 punct /,parkin
R1025 T1757 T1753 punct −,parkin
R1026 T1758 T1759 amod mitochondrial,dysfunction
R1027 T1759 T1746 dobj dysfunction,exhibit
R1028 T1760 T1759 cc and,dysfunction
R1029 T1761 T1762 nmod energy,deficits
R1030 T1762 T1759 conj deficits,dysfunction
R1031 T1763 T1761 cc and,energy
R1032 T1764 T1761 conj growth,energy
R1033 T1765 T1746 punct ", ",exhibit
R1034 T1766 T1746 cc and,exhibit
R1035 T1767 T1768 det a,fraction
R1036 T1768 T1769 nsubj fraction,localizes
R1037 T1815 T1814 pobj RanBP2,in
R1038 T1769 T1746 conj localizes,exhibit
R1039 T1816 T1815 cc and,RanBP2
R1040 T1770 T1768 prep of,fraction
R1041 T1817 T1815 conj parkin,RanBP2
R1042 T1818 T1812 aux may,share
R1043 T1819 T1820 punct (,physiological
R1044 T1771 T1770 pobj parkin,of
R1045 T1820 T1823 amod physiological,pathways
R1046 T1821 T1820 advmod patho,physiological
R1047 T1772 T1769 prep to,localizes
R1048 T1822 T1820 punct ),physiological
R1049 T1823 T1812 dobj pathways,share
R1050 T1824 T1812 cc and,share
R1051 T1825 T1812 conj support,share
R1052 T1826 T1827 det a,role
R1053 T1827 T1825 dobj role,support
R1054 T1773 T1774 det the,face
R1055 T1828 T1827 amod multifaceted,role
R1056 T1829 T1827 prep of,role
R1057 T1830 T1829 pobj RanBP2,of
R1058 T1831 T1810 punct .,suggest
R1059 T1774 T1772 pobj face,to
R1060 T1833 T1834 advmod Yet,remain
R1061 T1775 T1774 amod cytoplasmic,face
R1062 T1835 T1836 amod clear,functions
R1063 T1836 T1834 nsubj functions,remain
R1064 T1776 T1774 prep of,face
R1065 T1837 T1836 prep of,functions
R1066 T1838 T1837 pobj RanBP2,of
R1067 T1839 T1836 prep in,functions
R1068 T1777 T1778 det the,mitochondria
R1069 T1840 T1841 nmod animal,physiology
R1070 T1841 T1839 pobj physiology,in
R1071 T1778 T1776 pobj mitochondria,of
R1072 T1842 T1840 cc and,animal
R1073 T1843 T1840 conj cell,animal
R1074 T1844 T1834 acomp elusive,remain
R1075 T1779 T1774 punct ", ",face
R1076 T1845 T1834 punct .,remain
R1077 T1847 T1848 advmod Here,report
R1078 T1780 T1781 advmod where,thought
R1079 T1781 T1774 relcl thought,face
R1080 T1849 T1848 punct ", ",report
R1081 T1850 T1848 nsubj we,report
R1082 T1851 T1848 prep on,report
R1083 T1782 T1781 advmod together,thought
R1084 T1852 T1853 det the,identification
R1085 T1783 T1782 prep with,together
R1086 T1853 T1851 pobj identification,on
R1087 T1854 T1853 cc and,identification
R1088 T1855 T1853 conj function,identification
R1089 T1784 T1785 amod other,partners
R1090 T1856 T1853 prep of,identification
R1091 T1857 T1858 nummod two,partners
R1092 T1785 T1783 pobj partners,with
R1093 T1858 T1856 pobj partners,of
R1094 T1859 T1858 amod novel,partners
R1095 T1860 T1858 prep of,partners
R1096 T1786 T1781 auxpass is,thought
R1097 T1861 T1860 pobj RanBP2,of
R1098 T1862 T1858 punct ", ",partners
R1099 T1787 T1788 aux to,promote
R1100 T1863 T1858 appos Cox11,partners
R1101 T1864 T1863 cc and,Cox11
R1102 T1865 T1866 compound hexokinase,type
R1103 T1788 T1781 xcomp promote,thought
R1104 T1866 T1863 conj type,Cox11
R1105 T1867 T1866 nummod I,type
R1106 T1868 T1866 punct (,type
R1107 T1869 T1866 appos HKI,type
R1108 T1870 T1858 punct ),partners
R1109 T1871 T1858 punct ", ",partners
R1110 T1789 T1790 det the,degradation
R1111 T1872 T1873 dep which,interact
R1112 T1873 T1858 relcl interact,partners
R1113 T1874 T1873 prep with,interact
R1114 T1790 T1788 dobj degradation,promote
R1115 T1875 T1876 det a,domain
R1116 T1876 T1874 pobj domain,with
R1117 T1877 T1876 amod large,domain
R1118 T1878 T1877 cc and,large
R1119 T1791 T1790 prep of,degradation
R1120 T1879 T1877 conj orphan,large
R1121 T1880 T1876 prep of,domain
R1122 T1792 T1793 amod selective,substrates
R1123 T1881 T1880 pobj RanBP2,of
R1124 T1882 T1876 punct ", ",domain
R1125 T1883 T1884 det the,domain
R1126 T1793 T1791 pobj substrates,of
R1127 T1884 T1876 appos domain,domain
R1128 T1885 T1886 npadvmod leucine,rich
R1129 T1886 T1884 amod rich,domain
R1130 T1794 T1793 amod mitochondrial,substrates
R1131 T1887 T1886 punct -,rich
R1132 T1795 T1788 cc and,promote
R1133 T1888 T1884 punct (,domain
R1134 T1889 T1884 appos LD,domain
R1135 T1890 T1851 punct ),on
R1136 T1891 T1851 punct ;,on
R1137 T1796 T1797 aux to,exert
R1138 T1892 T1851 cc and,on
R1139 T1893 T1851 conj on,on
R1140 T1894 T1895 det the,outcome
R1141 T1797 T1788 conj exert,promote
R1142 T1895 T1893 pobj outcome,on
R1143 T1896 T1895 prep of,outcome
R1144 T1798 T1799 det a,function
R1145 T1799 T1797 dobj function,exert
R1146 T1897 T1898 amod partial,loss
R1147 T1898 T1896 pobj loss,of
R1148 T1800 T1799 amod neuroprotective,function
R1149 T1899 T1898 punct -,loss
R1150 T1900 T1898 prep of,loss
R1151 T1901 T1900 punct -,of
R1152 T1801 T1802 punct [,26
R1153 T1902 T1900 pobj function,of
R1154 T1903 T1898 prep of,loss
R1155 T1904 T1903 pobj RanBP2,of
R1156 T1905 T1895 prep on,outcome
R1157 T1906 T1905 pobj HKI,on
R1158 T1907 T1906 punct ", ",HKI
R1159 T1802 T1797 parataxis 26,exert
R1160 T1908 T1909 compound animal,physiology
R1161 T1909 T1906 conj physiology,HKI
R1162 T1910 T1909 punct ", ",physiology
R1163 T1803 T1804 punct –,29
R1164 T1911 T1909 cc and,physiology
R1165 T1912 T1913 compound glucose,energy
R1166 T1913 T1915 compound energy,metabolism
R1167 T1804 T1802 prep 29,26
R1168 T1914 T1913 punct /,energy
R1169 T1915 T1909 conj metabolism,physiology
R1170 T1805 T1802 punct ],26
R1171 T1916 T1848 punct .,report
R1172 T1806 T1769 punct .,localizes
R1173 T1808 T1809 det These,data
R1174 T1809 T1810 nsubj data,suggest
R1175 T1811 T1812 mark that,share
R1176 T1812 T1810 ccomp share,suggest
R1177 T1813 T1812 nsubj deficits,share
R1178 T1814 T1813 prep in,deficits
R338 T1039 T1040 det The,Nup358
R339 T1040 T1043 nsubj Nup358,is
R340 T1041 T1040 compound RanBP2,Nup358
R341 T1042 T1040 punct /,Nup358
R342 T1044 T1045 det a,protein
R343 T1045 T1043 attr protein,is
R344 T1046 T1045 amod unique,protein
R345 T1047 T1045 nmod vertebrate,protein
R346 T1048 T1047 cc and,vertebrate
R347 T1049 T1050 amod large,scaffold
R348 T1050 T1047 conj scaffold,vertebrate
R349 T1051 T1045 acl comprised,protein
R350 T1052 T1051 prep of,comprised
R351 T1053 T1054 amod multiple,domains
R352 T1054 T1052 pobj domains,of
R353 T1055 T1054 amod structural,domains
R354 T1056 T1055 cc and,structural
R355 T1057 T1055 conj functional,structural
R356 T1058 T1059 punct [,1
R357 T1059 T1043 parataxis 1,is
R358 T1060 T1061 punct –,4
R359 T1061 T1059 prep 4,1
R360 T1062 T1059 punct ],1
R361 T1063 T1043 punct .,is
R362 T1065 T1066 amod Several,roles
R363 T1066 T1067 nsubj roles,emerged
R364 T1068 T1066 prep of,roles
R365 T1069 T1068 pobj RanBP2,of
R366 T1070 T1067 aux have,emerged
R367 T1071 T1072 dep that,implicate
R368 T1072 T1067 ccomp implicate,emerged
R369 T1073 T1072 dobj RanBP2,implicate
R370 T1074 T1072 prep in,implicate
R371 T1075 T1076 amod nucleocytoplasmic,trafficking
R372 T1076 T1074 pobj trafficking,in
R373 T1077 T1078 punct [,5
R374 T1078 T1076 parataxis 5,trafficking
R375 T1079 T1078 nummod 3,5
R376 T1080 T1078 punct ",",5
R377 T1081 T1078 punct ],5
R378 T1082 T1076 punct ", ",trafficking
R379 T1083 T1084 compound protein,biogenesis
R380 T1084 T1076 conj biogenesis,trafficking
R381 T1085 T1086 punct [,7
R382 T1086 T1084 parataxis 7,biogenesis
R383 T1087 T1086 nummod 6,7
R384 T1088 T1086 punct ",",7
R385 T1089 T1086 punct ],7
R386 T1090 T1084 punct ", ",biogenesis
R387 T1091 T1092 det the,formation
R388 T1092 T1084 conj formation,biogenesis
R389 T1093 T1092 prep of,formation
R390 T1094 T1095 det the,spindle
R391 T1095 T1093 pobj spindle,of
R392 T1096 T1095 amod mitotic,spindle
R393 T1097 T1092 punct ", ",formation
R394 T1098 T1092 conj assembly,formation
R395 T1099 T1098 prep of,assembly
R396 T1100 T1101 det the,envelope
R397 T1101 T1099 pobj envelope,of
R398 T1102 T1101 amod nuclear,envelope
R399 T1103 T1104 punct [,8
R400 T1104 T1098 parataxis 8,assembly
R401 T1105 T1104 punct ],8
R402 T1106 T1098 punct ", ",assembly
R403 T1107 T1098 cc and,assembly
R404 T1108 T1109 det the,integration
R405 T1109 T1098 conj integration,assembly
R406 T1110 T1109 prep of,integration
R407 T1111 T1112 det the,breakdown
R408 T1112 T1110 pobj breakdown,of
R409 T1113 T1114 amod nuclear,envelope
R410 T1114 T1112 compound envelope,breakdown
R411 T1115 T1109 prep with,integration
R412 T1116 T1117 compound kinetochore,formation
R413 T1117 T1115 pobj formation,with
R414 T1118 T1117 cc and,formation
R415 T1119 T1117 conj maturation,formation
R416 T1120 T1109 prep during,integration
R417 T1121 T1122 amod early,progression
R418 T1122 T1120 pobj progression,during
R419 T1123 T1122 amod mitotic,progression
R420 T1124 T1125 punct [,9
R421 T1125 T1109 parataxis 9,integration
R422 T1126 T1125 punct ],9
R423 T1127 T1067 punct .,emerged
R424 T1129 T1130 det The,interaction
R425 T1130 T1132 nsubj interaction,reflects
R426 T1131 T1130 amod specific,interaction
R427 T1133 T1130 prep of,interaction
R428 T1134 T1133 pobj RanBP2,of
R429 T1135 T1130 prep with,interaction
R430 T1136 T1137 det a,set
R431 T1137 T1135 pobj set,with
R432 T1138 T1137 amod diverse,set
R433 T1139 T1137 prep of,set
R434 T1140 T1139 pobj partners,of
R435 T1141 T1132 advmod likely,reflects
R436 T1142 T1143 det a,role
R437 T1143 T1132 dobj role,reflects
R438 T1144 T1143 amod pleiotropic,role
R439 T1145 T1143 prep of,role
R440 T1146 T1145 pobj RanBP2,of
R441 T1147 T1143 prep in,role
R442 T1148 T1149 compound cell,function
R443 T1149 T1147 pobj function,in
R444 T1150 T1143 punct ", ",role
R445 T1151 T1152 advmod possibly,through
R446 T1152 T1143 prep through,role
R447 T1153 T1154 det the,integration
R448 T1154 T1152 pobj integration,through
R449 T1155 T1154 prep of,integration
R450 T1156 T1157 amod multiple,pathways
R451 T1157 T1155 pobj pathways,of
R452 T1158 T1132 punct .,reflects
R453 T1160 T1161 prep On,impart
R454 T1162 T1163 det the,hand
R455 T1163 T1160 pobj hand,On
R456 T1164 T1163 amod other,hand
R457 T1165 T1161 punct ", ",impart
R458 T1166 T1167 det the,interaction
R459 T1167 T1161 nsubj interaction,impart
R460 T1168 T1169 npadvmod cell,selective
R461 T1169 T1167 amod selective,interaction
R462 T1170 T1168 punct (,cell
R463 T1171 T1168 appos tissue,cell
R464 T1172 T1169 punct ),selective
R465 T1173 T1169 punct -,selective
R466 T1174 T1167 prep of,interaction
R467 T1175 T1174 pobj RanBP2,of
R468 T1176 T1167 prep with,interaction
R469 T1177 T1176 pobj some,with
R470 T1178 T1177 prep of,some
R471 T1179 T1180 poss its,partners
R472 T1180 T1178 pobj partners,of
R473 T1181 T1161 aux may,impart
R474 T1182 T1161 advmod also,impart
R475 T1183 T1184 npadvmod cell,restricted
R476 T1184 T1186 amod restricted,roles
R477 T1185 T1184 punct -,restricted
R478 T1186 T1161 dobj roles,impart
R479 T1187 T1161 prep to,impart
R480 T1188 T1187 pobj RanBP2,to
R481 T1189 T1161 punct .,impart
R482 T1191 T1192 prep For,associate
R483 T1193 T1191 pobj example,For
R484 T1194 T1192 punct ", ",associate
R485 T1195 T1196 det the,domains
R486 T1196 T1192 nsubj domains,associate
R487 T1197 T1198 npadvmod Ran,binding
R488 T1198 T1196 amod binding,domains
R489 T1199 T1198 punct -,binding
R490 T1200 T1201 nsubj RBDn,1
R491 T1201 T1196 appos 1,domains
R492 T1202 T1201 punct =,1
R493 T1203 T1204 punct -,4
R494 T1204 T1201 prep 4,1
R495 T1205 T1196 prep of,domains
R496 T1206 T1205 pobj RanBP2,of
R497 T1207 T1192 prep with,associate
R498 T1208 T1209 det the,co-receptor
R499 T1209 T1207 pobj co-receptor,with
R500 T1210 T1209 amod nuclear,co-receptor
R501 T1211 T1209 compound import,co-receptor
R502 T1212 T1209 punct ", ",co-receptor
R503 T1213 T1214 compound importin,β
R504 T1214 T1209 appos β,co-receptor
R505 T1215 T1214 punct -,β
R506 T1216 T1217 punct [,11
R507 T1217 T1192 parataxis 11,associate
R508 T1218 T1217 nummod 10,11
R509 T1219 T1217 punct ",",11
R510 T1220 T1217 punct ],11
R511 T1221 T1192 punct ", ",associate
R512 T1222 T1192 cc and,associate
R513 T1223 T1224 nsubj antibodies,inhibit
R514 T1224 T1192 conj inhibit,associate
R515 T1225 T1223 prep against,antibodies
R516 T1226 T1225 pobj RanBP2,against
R517 T1227 T1228 det the,pathway
R518 T1228 T1224 dobj pathway,inhibit
R519 T1229 T1230 amod nuclear,import
R520 T1230 T1228 compound import,pathway
R521 T1231 T1228 prep in,pathway
R522 T1232 T1233 compound HeLa,cells
R523 T1233 T1231 pobj cells,in
R524 T1234 T1235 punct [,3
R525 T1235 T1224 parataxis 3,inhibit
R526 T1236 T1235 punct ],3
R527 T1237 T1224 punct ;,inhibit
R528 T1238 T1224 cc but,inhibit
R529 T1239 T1240 predet such,role
R530 T1240 T1242 nsubj role,seems
R531 T1241 T1240 det a,role
R532 T1242 T1224 conj seems,inhibit
R533 T1243 T1242 oprd dispensable,seems
R534 T1244 T1242 prep in,seems
R535 T1245 T1246 compound Xenopus,oocytes
R536 T1246 T1244 pobj oocytes,in
R537 T1247 T1248 punct [,12
R538 T1248 T1242 parataxis 12,seems
R539 T1249 T1248 punct ],12
R540 T1250 T1242 punct .,seems
R541 T1252 T1253 prep In,associates
R542 T1254 T1252 pobj addition,In
R543 T1255 T1253 punct ", ",associates
R544 T1256 T1257 det the,combination
R545 T1257 T1253 nsubj combination,associates
R546 T1258 T1257 prep of,combination
R547 T1259 T1260 det the,domains
R548 T1260 T1258 pobj domains,of
R549 T1261 T1262 npadvmod C,terminal
R550 T1262 T1260 amod terminal,domains
R551 T1263 T1262 punct -,terminal
R552 T1264 T1260 punct ", ",domains
R553 T1265 T1260 appos RBD4,domains
R554 T1266 T1265 cc and,RBD4
R555 T1267 T1265 conj CY,RBD4
R556 T1268 T1260 punct (,domains
R557 T1269 T1260 prep of,domains
R558 T1270 T1269 pobj RanBP2,of
R559 T1271 T1253 punct ),associates
R560 T1272 T1253 punct ", ",associates
R561 T1273 T1253 prep with,associates
R562 T1274 T1275 det a,subset
R563 T1275 T1273 pobj subset,with
R564 T1276 T1275 prep of,subset
R565 T1277 T1278 compound G,protein
R566 T1278 T1279 npadvmod protein,coupled
R567 T1279 T1281 amod coupled,receptors
R568 T1280 T1279 punct -,coupled
R569 T1281 T1276 pobj receptors,of
R570 T1282 T1275 punct ", ",subset
R571 T1283 T1284 det the,opsin
R572 T1284 T1275 appos opsin,subset
R573 T1285 T1286 amod red,green
R574 T1286 T1284 amod green,opsin
R575 T1287 T1286 punct /,green
R576 T1288 T1284 punct ", ",opsin
R577 T1289 T1284 acl expressed,opsin
R578 T1290 T1289 prep in,expressed
R579 T1291 T1292 amod photosensory,neurons
R580 T1292 T1290 pobj neurons,in
R581 T1293 T1253 cc and,associates
R582 T1294 T1253 conj enhances,associates
R583 T1295 T1296 nmod opsin,production
R584 T1296 T1294 dobj production,enhances
R585 T1297 T1296 amod functional,production
R586 T1298 T1299 punct [,7
R587 T1299 T1294 parataxis 7,enhances
R588 T1300 T1299 nummod 6,7
R589 T1301 T1299 punct ",",7
R590 T1302 T1299 punct ],7
R591 T1303 T1253 punct ", ",associates
R592 T1304 T1305 mark while,occurs
R593 T1305 T1253 advcl occurs,associates
R594 T1306 T1307 det the,interaction
R595 T1307 T1305 nsubj interaction,occurs
R596 T1308 T1307 prep of,interaction
R597 T1309 T1310 det the,KBD
R598 T1310 T1308 pobj KBD,of
R599 T1311 T1310 prep of,KBD
R600 T1312 T1311 pobj RanBP2,of
R601 T1313 T1307 prep with,interaction
R602 T1314 T1315 det a,subset
R603 T1315 T1313 pobj subset,with
R604 T1316 T1315 prep of,subset
R605 T1317 T1318 det the,proteins
R606 T1318 T1316 pobj proteins,of
R607 T1319 T1318 amod conventional,proteins
R608 T1320 T1321 npadvmod microtubule,based
R609 T1321 T1318 amod based,proteins
R610 T1322 T1321 punct -,based
R611 T1323 T1318 compound motor,proteins
R612 T1324 T1315 punct ", ",subset
R613 T1325 T1326 det the,kinesins
R614 T1326 T1315 appos kinesins,subset
R615 T1327 T1326 punct ", ",kinesins
R616 T1328 T1326 appos KIF5B,kinesins
R617 T1329 T1328 cc and,KIF5B
R618 T1330 T1328 conj KIF5C,KIF5B
R619 T1331 T1305 punct ", ",occurs
R620 T1332 T1305 advmod selectively,occurs
R621 T1333 T1305 prep in,occurs
R622 T1334 T1335 det the,system
R623 T1335 T1333 pobj system,in
R624 T1336 T1335 amod central,system
R625 T1337 T1335 amod nervous,system
R626 T1338 T1335 punct (,system
R627 T1339 T1335 appos CNS,system
R628 T1340 T1305 punct ),occurs
R629 T1341 T1342 punct [,13
R630 T1342 T1305 parataxis 13,occurs
R631 T1343 T1342 punct ],13
R632 T1344 T1253 punct .,associates
R633 T1346 T1347 det A,set
R634 T1347 T1349 nsubj set,are
R635 T1348 T1347 amod diverse,set
R636 T1350 T1347 prep of,set
R637 T1351 T1352 amod additional,partners
R638 T1352 T1350 pobj partners,of
R639 T1353 T1352 amod molecular,partners
R640 T1354 T1347 punct ", ",set
R641 T1355 T1347 appos each,set
R642 T1356 T1355 acl associating,each
R643 T1357 T1356 advmod specifically,associating
R644 T1358 T1356 prep with,associating
R645 T1359 T1360 det a,domain
R646 T1360 T1358 pobj domain,with
R647 T1361 T1360 amod selective,domain
R648 T1362 T1360 prep of,domain
R649 T1363 T1362 pobj RanBP2,of
R650 T1364 T1349 punct ", ",are
R651 T1365 T1349 acomp likely,are
R652 T1366 T1367 aux to,impart
R653 T1367 T1365 xcomp impart,likely
R654 T1368 T1367 cc and,impart
R655 T1369 T1367 conj integrate,impart
R656 T1370 T1371 amod additional,roles
R657 T1371 T1369 dobj roles,integrate
R658 T1372 T1371 prep to,roles
R659 T1373 T1372 pobj RanBP2,to
R660 T1374 T1349 punct .,are
R661 T1376 T1377 prep For,associate
R662 T1378 T1376 pobj example,For
R663 T1379 T1377 punct ", ",associate
R664 T1380 T1381 det the,domain
R665 T1381 T1377 nsubj domain,associate
R666 T1382 T1383 npadvmod cyclophilin,like
R667 T1383 T1381 amod like,domain
R668 T1384 T1383 punct -,like
R669 T1385 T1381 punct (,domain
R670 T1386 T1381 appos CLD,domain
R671 T1387 T1381 punct ),domain
R672 T1388 T1381 punct ", ",domain
R673 T1389 T1390 det the,domains
R674 T1390 T1381 appos domains,domain
R675 T1391 T1392 amod internal,repeat
R676 T1392 T1390 nmod repeat,domains
R677 T1393 T1394 punct (,IR
R678 T1394 T1392 parataxis IR,repeat
R679 T1395 T1394 compound W1W2,IR
R680 T1396 T1394 punct /,IR
R681 T1397 T1394 punct ),IR
R682 T1398 T1392 punct ", ",repeat
R683 T1399 T1392 cc and,repeat
R684 T1400 T1401 compound zinc,finger
R685 T1401 T1403 npadvmod finger,rich
R686 T1402 T1401 punct -,finger
R687 T1403 T1392 conj rich,repeat
R688 T1404 T1405 punct (,ZnF
R689 T1405 T1403 parataxis ZnF,rich
R690 T1406 T1405 punct ),ZnF
R691 T1407 T1381 prep of,domain
R692 T1408 T1407 pobj RanBP2,of
R693 T1409 T1377 advmod specifically,associate
R694 T1410 T1377 prep with,associate
R695 T1411 T1410 pobj components,with
R696 T1412 T1411 prep of,components
R697 T1413 T1414 det the,cap
R698 T1414 T1412 pobj cap,of
R699 T1415 T1414 compound 19S,cap
R700 T1416 T1414 prep of,cap
R701 T1417 T1418 det the,proteasome
R702 T1418 T1416 pobj proteasome,of
R703 T1419 T1420 punct [,14
R704 T1420 T1414 parataxis 14,cap
R705 T1421 T1420 punct ],14
R706 T1422 T1414 punct ", ",cap
R707 T1423 T1424 det the,enzyme
R708 T1424 T1414 conj enzyme,cap
R709 T1425 T1424 nmod E2,enzyme
R710 T1426 T1427 npadvmod SUMO,conjugating
R711 T1427 T1424 amod conjugating,enzyme
R712 T1428 T1426 punct -,SUMO
R713 T1429 T1426 nummod 1,SUMO
R714 T1430 T1426 punct -,SUMO
R715 T1431 T1424 punct (,enzyme
R716 T1432 T1424 appos Ubc9,enzyme
R717 T1433 T1424 punct ),enzyme
R718 T1434 T1435 punct [,15
R719 T1435 T1424 parataxis 15,enzyme
R720 T1436 T1435 punct ],15
R721 T1437 T1424 punct ", ",enzyme
R722 T1438 T1424 cc and,enzyme
R723 T1439 T1440 det the,receptor
R724 T1440 T1424 conj receptor,enzyme
R725 T1441 T1442 amod nuclear,export
R726 T1442 T1440 compound export,receptor
R727 T1443 T1440 punct ", ",receptor
R728 T1444 T1445 compound CRM1,exportin
R729 T1445 T1440 appos exportin,receptor
R730 T1446 T1445 punct /,exportin
R731 T1447 T1445 punct -,exportin
R732 T1448 T1445 nummod 1,exportin
R733 T1449 T1450 punct [,16
R734 T1450 T1440 parataxis 16,receptor
R735 T1451 T1450 punct ],16
R736 T1452 T1377 punct ", ",associate
R737 T1453 T1377 advmod respectively,associate
R738 T1454 T1377 punct .,associate
R739 T1456 T1457 nsubjpass RanBP2,found
R740 T1458 T1457 npadvmod itself,found
R741 T1459 T1457 auxpass was,found
R742 T1460 T1457 advmod also,found
R743 T1461 T1462 aux to,exhibit
R744 T1462 T1457 xcomp exhibit,found
R745 T1463 T1464 compound SUMO1,ligase
R746 T1464 T1466 compound ligase,activity
R747 T1465 T1464 compound E3,ligase
R748 T1466 T1462 dobj activity,exhibit
R749 T1467 T1468 punct [,17
R750 T1468 T1462 parataxis 17,exhibit
R751 T1469 T1468 punct ],17
R752 T1470 T1462 punct ", ",exhibit
R753 T1471 T1462 advcl supporting,exhibit
R754 T1472 T1473 det a,link
R755 T1473 T1471 dobj link,supporting
R756 T1474 T1473 amod direct,link
R757 T1475 T1473 prep between,link
R758 T1476 T1477 npadvmod RanBP2,mediated
R759 T1477 T1479 amod mediated,modification
R760 T1478 T1477 punct -,mediated
R761 T1479 T1475 pobj modification,between
R762 T1480 T1481 nmod SUMO,substrate
R763 T1481 T1479 compound substrate,modification
R764 T1482 T1480 punct -,SUMO
R765 T1483 T1480 nummod 1,SUMO
R766 T1484 T1479 cc and,modification
R767 T1485 T1479 conj relocation,modification
R768 T1486 T1485 prep of,relocation
R769 T1487 T1488 npadvmod SUMO,modified
R770 T1488 T1491 amod modified,substrates
R771 T1489 T1487 punct -,SUMO
R772 T1490 T1487 nummod 1,SUMO
R773 T1491 T1486 pobj substrates,of
R774 T1492 T1491 amod cytosolic,substrates
R775 T1493 T1491 punct (,substrates
R776 T1494 T1495 advmod e.g.,RanGAP
R777 T1495 T1491 appos RanGAP,substrates
R778 T1496 T1495 punct ", ",RanGAP
R779 T1497 T1485 punct ),relocation
R780 T1498 T1485 prep to,relocation
R781 T1499 T1500 det the,face
R782 T1500 T1498 pobj face,to
R783 T1501 T1500 amod cytosolic,face
R784 T1502 T1500 prep of,face
R785 T1503 T1504 det the,complex
R786 T1504 T1502 pobj complex,of
R787 T1505 T1504 amod nuclear,complex
R788 T1506 T1504 compound pore,complex
R789 T1507 T1504 punct (,complex
R790 T1508 T1504 appos NPC,complex
R791 T1509 T1471 punct ),supporting
R792 T1510 T1511 punct [,18
R793 T1511 T1471 parataxis 18,supporting
R794 T1512 T1511 punct ],18
R795 T1513 T1457 punct .,found
R796 T1515 T1516 advmod Finally,found
R797 T1517 T1516 punct ", ",found
R798 T1518 T1516 nsubjpass RanBP2,found
R799 T1519 T1516 auxpass was,found
R800 T1520 T1516 advmod also,found
R801 T1521 T1522 aux to,localize
R802 T1522 T1516 xcomp localize,found
R803 T1523 T1522 advmod prominently,localize
R804 T1524 T1522 prep to,localize
R805 T1525 T1526 det the,compartment
R806 T1526 T1524 pobj compartment,to
R807 T1527 T1528 npadvmod mitochondria,rich
R808 T1528 T1526 amod rich,compartment
R809 T1529 T1528 punct -,rich
R810 T1530 T1526 amod ellipsoid,compartment
R811 T1531 T1526 amod subcellular,compartment
R812 T1532 T1526 prep of,compartment
R813 T1533 T1534 amod photosensory,neurons
R814 T1534 T1532 pobj neurons,of
R815 T1535 T1536 punct [,19
R816 T1536 T1526 parataxis 19,compartment
R817 T1537 T1536 punct ],19
R818 T1538 T1524 cc and,to
R819 T1539 T1524 conj to,to
R820 T1540 T1541 npadvmod RanGTPase,restricted
R821 T1541 T1543 amod restricted,foci
R822 T1542 T1541 punct -,restricted
R823 T1543 T1539 pobj foci,to
R824 T1544 T1543 prep along,foci
R825 T1545 T1546 amod cytoplasmic,tracks
R826 T1546 T1544 pobj tracks,along
R827 T1547 T1548 punct [,19
R828 T1548 T1546 parataxis 19,tracks
R829 T1549 T1548 punct ],19
R830 T1550 T1522 punct ", ",localize
R831 T1551 T1522 prep in,localize
R832 T1552 T1551 pobj addition,in
R833 T1553 T1552 prep to,addition
R834 T1554 T1555 poss its,localization
R835 T1555 T1553 pobj localization,to
R836 T1556 T1555 prep at,localization
R837 T1557 T1558 amod cytoplasmic,fibrils
R838 T1558 T1556 pobj fibrils,at
R839 T1559 T1558 acl emanating,fibrils
R840 T1560 T1559 prep from,emanating
R841 T1561 T1562 amod nuclear,pores
R842 T1562 T1560 pobj pores,from
R843 T1563 T1564 punct [,19
R844 T1564 T1522 parataxis 19,localize
R845 T1565 T1564 nummod 2,19
R846 T1566 T1564 punct ",",19
R847 T1567 T1564 nummod 3,19
R848 T1568 T1564 punct ",",19
R849 T1569 T1564 nummod 10,19
R850 T1570 T1564 punct ",",19
R851 T1571 T1564 nummod 12,19
R852 T1572 T1564 punct ",",19
R853 T1573 T1564 punct ],19
R854 T1574 T1516 punct .,found
R855 T1576 T1577 amod Emerging,evidence
R856 T1577 T1578 nsubj evidence,supports
R857 T1579 T1580 mark that,underlie
R858 T1580 T1578 ccomp underlie,supports
R859 T1581 T1582 det the,effects
R860 T1582 T1580 nsubj effects,underlie
R861 T1583 T1584 npadvmod CNS,selective
R862 T1584 T1582 amod selective,effects
R863 T1585 T1584 punct -,selective
R864 T1586 T1582 prep of,effects
R865 T1587 T1586 pobj RanBP2,of
R866 T1588 T1580 aux may,underlie
R867 T1589 T1580 advmod also,underlie
R868 T1590 T1591 det the,pathogenesis
R869 T1591 T1580 dobj pathogenesis,underlie
R870 T1592 T1591 prep of,pathogenesis
R871 T1593 T1594 amod certain,neuropathies
R872 T1594 T1592 pobj neuropathies,of
R873 T1595 T1578 punct .,supports
R874 T1597 T1598 nsubjpass Parkin,expressed
R875 T1599 T1598 auxpass is,expressed
R876 T1600 T1598 advmod ubiquitously,expressed
R877 T1601 T1598 cc and,expressed
R878 T1602 T1598 conj interacts,expressed
R879 T1603 T1602 prep with,interacts
R880 T1604 T1605 det the,domain
R881 T1605 T1603 pobj domain,with
R882 T1606 T1607 npadvmod Ubc9,interacting
R883 T1607 T1605 amod interacting,domain
R884 T1608 T1607 punct -,interacting
R885 T1609 T1605 prep of,domain
R886 T1610 T1609 pobj RanBP2,of
R887 T1611 T1612 punct [,20
R888 T1612 T1602 parataxis 20,interacts
R889 T1613 T1612 punct ],20
R890 T1614 T1598 punct .,expressed
R891 T1616 T1617 nsubj This,promotes
R892 T1618 T1619 det the,ubiquitination
R893 T1619 T1617 dobj ubiquitination,promotes
R894 T1620 T1619 cc and,ubiquitination
R895 T1621 T1619 conj degradation,ubiquitination
R896 T1622 T1619 prep of,ubiquitination
R897 T1623 T1622 pobj RanBP2,of
R898 T1624 T1625 punct [,20
R899 T1625 T1619 parataxis 20,ubiquitination
R900 T1626 T1625 punct ],20
R901 T1627 T1617 punct ", ",promotes
R902 T1628 T1629 advmod possibly,via
R903 T1629 T1617 prep via,promotes
R904 T1630 T1631 det the,interaction
R905 T1631 T1629 pobj interaction,via
R906 T1632 T1631 prep of,interaction
R907 T1633 T1634 det the,domain
R908 T1634 T1632 pobj domain,of
R909 T1635 T1634 compound CLD,domain
R910 T1636 T1634 prep of,domain
R911 T1637 T1636 pobj RanBP2,of
R912 T1638 T1631 prep with,interaction
R913 T1639 T1640 det the,subunits
R914 T1640 T1638 pobj subunits,with
R915 T1641 T1642 compound 19S,cap
R916 T1642 T1640 compound cap,subunits
R917 T1643 T1640 prep of,subunits
R918 T1644 T1645 det the,proteasome
R919 T1645 T1643 pobj proteasome,of
R920 T1646 T1647 punct [,14
R921 T1647 T1631 parataxis 14,interaction
R922 T1648 T1647 punct ],14
R923 T1649 T1617 punct .,promotes
R924 T1651 T1652 advmod Interestingly,required
R925 T1653 T1652 punct ", ",required
R926 T1654 T1655 det the,protein
R927 T1655 T1652 nsubjpass protein,required
R928 T1656 T1655 amod small,protein
R929 T1657 T1655 nmod yeast,protein
R930 T1658 T1659 npadvmod Ran,binding
R931 T1659 T1655 amod binding,protein
R932 T1660 T1659 punct -,binding
R933 T1661 T1655 nummod 1,protein
R934 T1662 T1655 punct (,protein
R935 T1663 T1655 appos RanBP1,protein
R936 T1664 T1655 punct ),protein
R937 T1665 T1655 punct ", ",protein
R938 T1666 T1655 appos Yrb1p,protein
R939 T1667 T1655 punct ", ",protein
R940 T1668 T1655 prep with,protein
R941 T1669 T1670 amod strong,homology
R942 T1670 T1668 pobj homology,with
R943 T1671 T1670 prep to,homology
R944 T1672 T1673 det the,domains
R945 T1673 T1671 pobj domains,to
R946 T1674 T1675 npadvmod Ran,binding
R947 T1675 T1673 amod binding,domains
R948 T1676 T1675 punct -,binding
R949 T1677 T1673 prep of,domains
R950 T1678 T1677 pobj RanBP2,of
R951 T1679 T1652 punct ", ",required
R952 T1680 T1652 auxpass is,required
R953 T1681 T1652 advmod also,required
R954 T1682 T1652 prep for,required
R955 T1683 T1684 compound cell,cycle
R956 T1684 T1686 npadvmod cycle,regulated
R957 T1685 T1684 punct -,cycle
R958 T1686 T1687 amod regulated,degradation
R959 T1687 T1682 pobj degradation,for
R960 T1688 T1687 compound protein,degradation
R961 T1689 T1690 punct [,21
R962 T1690 T1652 parataxis 21,required
R963 T1691 T1690 punct ],21
R964 T1692 T1652 punct .,required
R965 T1694 T1695 nsubj Parkin,has
R966 T1696 T1694 punct ", ",Parkin
R967 T1697 T1694 prep like,Parkin
R968 T1698 T1697 pobj RanBP2,like
R969 T1699 T1700 punct [,17
R970 T1700 T1694 parataxis 17,Parkin
R971 T1701 T1700 punct ],17
R972 T1702 T1695 punct ", ",has
R973 T1703 T1704 compound E3,ligase
R974 T1704 T1706 compound ligase,activity
R975 T1705 T1704 punct -,ligase
R976 T1706 T1695 dobj activity,has
R977 T1707 T1708 punct [,22
R978 T1708 T1695 parataxis 22,has
R979 T1709 T1710 punct –,24
R980 T1710 T1708 prep 24,22
R981 T1711 T1708 punct ],22
R982 T1712 T1695 punct ;,has
R983 T1713 T1695 cc and,has
R984 T1714 T1715 nsubj loss,leads
R985 T1715 T1695 conj leads,has
R986 T1716 T1714 punct -,loss
R987 T1717 T1714 prep of,loss
R988 T1718 T1717 punct -,of
R989 T1719 T1717 pobj function,of
R990 T1720 T1714 prep of,loss
R991 T1721 T1720 pobj parkin,of
R992 T1722 T1715 prep to,leads
R993 T1723 T1724 amod early,onset
R994 T1724 T1725 nmod onset,Parkinsonism
R995 T1725 T1722 pobj Parkinsonism,to
R996 T1726 T1727 amod autosomal,recessive
R997 T1727 T1725 amod recessive,Parkinsonism
R998 T1728 T1725 amod juvenile,Parkinsonism
R999 T1729 T1730 punct [,25