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PMC:138691 / 4571-5549 JSONTXT 4 Projects

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Id Subject Object Predicate Lexical cue
T1188 0-8 NNP denotes Moynahan
T1190 9-11 FW denotes et
T1191 12-14 FW denotes al
T1192 15-16 -LRB- denotes [
T1193 16-18 CD denotes 24
T1194 18-19 -RRB- denotes ]
T1195 20-24 VBP denotes have
T1189 25-29 VBN denotes used
T1196 30-34 PDT denotes such
T1198 35-36 DT denotes a
T1199 37-40 NN denotes GFP
T1200 41-54 NN denotes recombination
T1197 55-64 NN denotes substrate
T1201 65-67 TO denotes to
T1202 68-79 VB denotes demonstrate
T1203 80-84 IN denotes that
T1205 85-90 NNS denotes cells
T1206 91-95 IN denotes with
T1207 96-105 JJ denotes defective
T1209 106-111 NN denotes BRCA2
T1208 112-119 NN denotes protein
T1204 120-123 VBP denotes are
T1210 124-133 JJ denotes deficient
T1211 134-136 IN denotes in
T1212 137-142 PRP$ denotes their
T1213 143-150 NN denotes ability
T1214 151-153 TO denotes to
T1215 154-160 VB denotes repair
T1216 161-164 DT denotes the
T1218 165-166 NN denotes I
T1220 166-167 HYPH denotes -
T1219 167-171 NN denotes SceI
T1222 171-172 HYPH denotes -
T1221 172-179 VBN denotes induced
T1217 180-183 NN denotes DSB
T1223 184-191 IN denotes through
T1224 192-202 JJ denotes homologous
T1225 203-216 NN denotes recombination
T1226 216-217 . denotes .
T1227 217-362 sentence denotes Expression of I-SceI resulted in 1 out of 1400 cells producing GFP via homologous recombination in the human pancreatic tumor cell line CAPAN-1.
T1228 218-228 NN denotes Expression
T1230 229-231 IN denotes of
T1231 232-233 NN denotes I
T1233 233-234 HYPH denotes -
T1232 234-238 NN denotes SceI
T1229 239-247 VBD denotes resulted
T1234 248-250 IN denotes in
T1235 251-252 CD denotes 1
T1237 253-256 IN denotes out
T1238 257-259 IN denotes of
T1236 260-264 CD denotes 1400
T1239 265-270 NNS denotes cells
T1240 271-280 VBG denotes producing
T1241 281-284 NN denotes GFP
T1242 285-288 IN denotes via
T1243 289-299 JJ denotes homologous
T1244 300-313 NN denotes recombination
T1245 314-316 IN denotes in
T1246 317-320 DT denotes the
T1248 321-326 JJ denotes human
T1250 327-337 JJ denotes pancreatic
T1251 338-343 NN denotes tumor
T1249 344-348 NN denotes cell
T1247 349-353 NN denotes line
T1252 354-359 NN denotes CAPAN
T1253 359-360 HYPH denotes -
T1254 360-361 CD denotes 1
T1255 361-362 . denotes .
T1256 362-492 sentence denotes CAPAN-1 cells carry a deletion of BRCA2 on one homolog and codes for a protein truncated at amino acid 1981 on the other homolog.
T1257 363-368 NN denotes CAPAN
T1259 368-369 HYPH denotes -
T1260 369-370 CD denotes 1
T1258 371-376 NNS denotes cells
T1261 377-382 VBP denotes carry
T1262 383-384 DT denotes a
T1263 385-393 NN denotes deletion
T1264 394-396 IN denotes of
T1265 397-402 NN denotes BRCA2
T1266 403-405 IN denotes on
T1267 406-409 CD denotes one
T1268 410-417 NN denotes homolog
T1269 418-421 CC denotes and
T1270 422-427 NNS denotes codes
T1271 428-431 IN denotes for
T1272 432-433 DT denotes a
T1273 434-441 NN denotes protein
T1274 442-451 VBN denotes truncated
T1275 452-454 IN denotes at
T1276 455-460 JJ denotes amino
T1277 461-465 NN denotes acid
T1278 466-470 CD denotes 1981
T1279 471-473 IN denotes on
T1280 474-477 DT denotes the
T1282 478-483 JJ denotes other
T1281 484-491 NN denotes homolog
T1283 491-492 . denotes .
T1284 492-653 sentence denotes The authors indicate that the level of I-SceI-induced recombination in CAPAN-1 is over 100-fold less than that seen using other (BRCA2+) human tumor cell lines.
T1285 493-496 DT denotes The
T1286 497-504 NNS denotes authors
T1287 505-513 VBP denotes indicate
T1288 514-518 IN denotes that
T1290 519-522 DT denotes the
T1291 523-528 NN denotes level
T1292 529-531 IN denotes of
T1293 532-533 NN denotes I
T1295 533-534 HYPH denotes -
T1294 534-538 NN denotes SceI
T1297 538-539 HYPH denotes -
T1296 539-546 VBN denotes induced
T1298 547-560 NN denotes recombination
T1299 561-563 IN denotes in
T1300 564-569 NN denotes CAPAN
T1301 569-570 HYPH denotes -
T1302 570-571 CD denotes 1
T1289 572-574 VBZ denotes is
T1303 575-579 IN denotes over
T1304 580-588 RB denotes 100-fold
T1305 589-593 JJR denotes less
T1306 594-598 IN denotes than
T1307 599-603 DT denotes that
T1308 604-608 VBN denotes seen
T1309 609-614 VBG denotes using
T1310 615-620 JJ denotes other
T1312 621-622 -LRB- denotes (
T1311 622-628 JJ denotes BRCA2+
T1314 628-629 -RRB- denotes )
T1315 630-635 JJ denotes human
T1316 636-641 NN denotes tumor
T1317 642-646 NN denotes cell
T1313 647-652 NNS denotes lines
T1318 652-653 . denotes .
T1319 653-830 sentence denotes The different lines examined, however, are very likely to differ genetically from CAPAN-1 cells not only at the BRCA2 locus, but also at a very large number of additional loci.
T1320 654-657 DT denotes The
T1322 658-667 JJ denotes different
T1321 668-673 NNS denotes lines
T1324 674-682 VBN denotes examined
T1325 682-684 , denotes ,
T1326 684-691 RB denotes however
T1327 691-693 , denotes ,
T1323 693-696 VBP denotes are
T1328 697-701 RB denotes very
T1329 702-708 JJ denotes likely
T1330 709-711 TO denotes to
T1331 712-718 VB denotes differ
T1332 719-730 RB denotes genetically
T1333 731-735 IN denotes from
T1334 736-741 NN denotes CAPAN
T1336 741-742 HYPH denotes -
T1337 742-743 CD denotes 1
T1335 744-749 NNS denotes cells
T1338 750-753 RB denotes not
T1340 754-758 RB denotes only
T1339 759-761 IN denotes at
T1341 762-765 DT denotes the
T1343 766-771 NN denotes BRCA2
T1342 772-777 NN denotes locus
T1344 777-779 , denotes ,
T1345 779-782 CC denotes but
T1346 783-787 RB denotes also
T1347 788-790 IN denotes at
T1348 791-792 DT denotes a
T1350 793-797 RB denotes very
T1351 798-803 JJ denotes large
T1349 804-810 NN denotes number
T1352 811-813 IN denotes of
T1353 814-824 JJ denotes additional
T1354 825-829 NNS denotes loci
T1355 829-830 . denotes .
T1356 830-978 sentence denotes This raises the possibility that some or even all of the recombinational repair defect seen in CAPAN-1 could be due to mutations at non-BRCA2 loci.
T1357 831-835 DT denotes This
T1358 836-842 VBZ denotes raises
T1359 843-846 DT denotes the
T1360 847-858 NN denotes possibility
T1361 859-863 IN denotes that
T1363 864-868 DT denotes some
T1364 869-871 CC denotes or
T1365 872-876 RB denotes even
T1366 877-880 DT denotes all
T1367 881-883 IN denotes of
T1368 884-887 DT denotes the
T1370 888-903 JJ denotes recombinational
T1371 904-910 NN denotes repair
T1369 911-917 NN denotes defect
T1372 918-922 VBN denotes seen
T1373 923-925 IN denotes in
T1374 926-931 NN denotes CAPAN
T1375 931-932 HYPH denotes -
T1376 932-933 CD denotes 1
T1377 934-939 MD denotes could
T1362 940-942 VB denotes be
T1378 943-946 IN denotes due
T1379 947-949 IN denotes to
T1380 950-959 NNS denotes mutations
T1381 960-962 IN denotes at
T1382 963-972 JJ denotes non-BRCA2
T1383 973-977 NNS denotes loci
T1384 977-978 . denotes .
R738 T1188 T1189 nsubj Moynahan,used
R739 T1190 T1191 advmod et,al
R740 T1191 T1188 advmod al,Moynahan
R741 T1192 T1193 punct [,24
R742 T1193 T1188 parataxis 24,Moynahan
R743 T1194 T1193 punct ],24
R744 T1195 T1189 aux have,used
R745 T1196 T1197 predet such,substrate
R746 T1197 T1189 dobj substrate,used
R747 T1198 T1197 det a,substrate
R748 T1199 T1200 compound GFP,recombination
R749 T1200 T1197 compound recombination,substrate
R750 T1201 T1202 aux to,demonstrate
R751 T1202 T1189 advcl demonstrate,used
R752 T1203 T1204 mark that,are
R753 T1204 T1202 ccomp are,demonstrate
R754 T1205 T1204 nsubj cells,are
R755 T1206 T1205 prep with,cells
R756 T1207 T1208 amod defective,protein
R757 T1208 T1206 pobj protein,with
R758 T1209 T1208 compound BRCA2,protein
R759 T1210 T1204 acomp deficient,are
R760 T1211 T1210 prep in,deficient
R761 T1212 T1213 poss their,ability
R762 T1213 T1211 pobj ability,in
R763 T1214 T1215 aux to,repair
R764 T1215 T1213 acl repair,ability
R765 T1216 T1217 det the,DSB
R766 T1217 T1215 dobj DSB,repair
R767 T1218 T1219 compound I,SceI
R768 T1219 T1221 npadvmod SceI,induced
R769 T1220 T1219 punct -,SceI
R770 T1221 T1217 amod induced,DSB
R771 T1222 T1221 punct -,induced
R772 T1223 T1215 prep through,repair
R773 T1224 T1225 amod homologous,recombination
R774 T1225 T1223 pobj recombination,through
R775 T1226 T1189 punct .,used
R776 T1228 T1229 nsubj Expression,resulted
R777 T1230 T1228 prep of,Expression
R778 T1231 T1232 compound I,SceI
R779 T1232 T1230 pobj SceI,of
R780 T1233 T1232 punct -,SceI
R781 T1234 T1229 prep in,resulted
R782 T1235 T1236 quantmod 1,1400
R783 T1236 T1239 nummod 1400,cells
R784 T1237 T1236 quantmod out,1400
R785 T1238 T1236 quantmod of,1400
R786 T1239 T1240 nsubj cells,producing
R787 T1240 T1234 pcomp producing,in
R788 T1241 T1240 dobj GFP,producing
R789 T1242 T1240 prep via,producing
R790 T1243 T1244 amod homologous,recombination
R791 T1244 T1242 pobj recombination,via
R792 T1245 T1244 prep in,recombination
R793 T1246 T1247 det the,line
R794 T1247 T1245 pobj line,in
R795 T1248 T1249 amod human,cell
R796 T1249 T1247 compound cell,line
R797 T1250 T1249 amod pancreatic,cell
R798 T1251 T1249 compound tumor,cell
R799 T1252 T1247 appos CAPAN,line
R800 T1253 T1252 punct -,CAPAN
R801 T1254 T1252 nummod 1,CAPAN
R802 T1255 T1229 punct .,resulted
R803 T1257 T1258 nmod CAPAN,cells
R804 T1258 T1261 nsubj cells,carry
R805 T1259 T1257 punct -,CAPAN
R806 T1260 T1257 nummod 1,CAPAN
R807 T1262 T1263 det a,deletion
R808 T1263 T1261 dobj deletion,carry
R809 T1264 T1263 prep of,deletion
R810 T1265 T1264 pobj BRCA2,of
R811 T1266 T1261 prep on,carry
R812 T1267 T1268 nummod one,homolog
R813 T1268 T1266 pobj homolog,on
R814 T1269 T1261 cc and,carry
R815 T1270 T1261 conj codes,carry
R816 T1271 T1270 prep for,codes
R817 T1272 T1273 det a,protein
R818 T1273 T1271 pobj protein,for
R819 T1274 T1273 acl truncated,protein
R820 T1275 T1274 prep at,truncated
R821 T1276 T1277 amod amino,acid
R822 T1277 T1275 pobj acid,at
R823 T1278 T1277 appos 1981,acid
R824 T1279 T1270 prep on,codes
R825 T1280 T1281 det the,homolog
R826 T1281 T1279 pobj homolog,on
R827 T1282 T1281 amod other,homolog
R828 T1283 T1261 punct .,carry
R829 T1285 T1286 det The,authors
R830 T1286 T1287 nsubj authors,indicate
R831 T1288 T1289 mark that,is
R832 T1289 T1287 ccomp is,indicate
R833 T1290 T1291 det the,level
R834 T1291 T1289 nsubj level,is
R835 T1292 T1291 prep of,level
R836 T1293 T1294 compound I,SceI
R837 T1294 T1296 npadvmod SceI,induced
R838 T1295 T1294 punct -,SceI
R839 T1296 T1298 amod induced,recombination
R840 T1297 T1296 punct -,induced
R841 T1298 T1292 pobj recombination,of
R842 T1299 T1291 prep in,level
R843 T1300 T1299 pobj CAPAN,in
R844 T1301 T1300 punct -,CAPAN
R845 T1302 T1300 nummod 1,CAPAN
R846 T1303 T1304 quantmod over,100-fold
R847 T1304 T1305 advmod 100-fold,less
R848 T1305 T1289 acomp less,is
R849 T1306 T1305 prep than,less
R850 T1307 T1306 pobj that,than
R851 T1308 T1307 acl seen,that
R852 T1309 T1308 advcl using,seen
R853 T1310 T1311 amod other,BRCA2+
R854 T1311 T1313 amod BRCA2+,lines
R855 T1312 T1311 punct (,BRCA2+
R856 T1313 T1309 dobj lines,using
R857 T1314 T1313 punct ),lines
R858 T1315 T1316 amod human,tumor
R859 T1316 T1317 compound tumor,cell
R860 T1317 T1313 compound cell,lines
R861 T1318 T1287 punct .,indicate
R862 T1320 T1321 det The,lines
R863 T1321 T1323 nsubj lines,are
R864 T1322 T1321 amod different,lines
R865 T1324 T1321 acl examined,lines
R866 T1325 T1323 punct ", ",are
R867 T1326 T1323 advmod however,are
R868 T1327 T1323 punct ", ",are
R869 T1328 T1329 advmod very,likely
R870 T1329 T1323 acomp likely,are
R871 T1330 T1331 aux to,differ
R872 T1331 T1329 xcomp differ,likely
R873 T1332 T1331 advmod genetically,differ
R874 T1333 T1331 prep from,differ
R875 T1334 T1335 nmod CAPAN,cells
R876 T1335 T1333 pobj cells,from
R877 T1336 T1334 punct -,CAPAN
R878 T1337 T1334 nummod 1,CAPAN
R879 T1338 T1339 preconj not,at
R880 T1339 T1331 prep at,differ
R881 T1340 T1338 advmod only,not
R882 T1341 T1342 det the,locus
R883 T1342 T1339 pobj locus,at
R884 T1343 T1342 compound BRCA2,locus
R885 T1344 T1339 punct ", ",at
R886 T1345 T1339 cc but,at
R887 T1346 T1345 advmod also,but
R888 T1347 T1339 conj at,at
R889 T1348 T1349 det a,number
R890 T1349 T1347 pobj number,at
R891 T1350 T1351 advmod very,large
R892 T1351 T1349 amod large,number
R893 T1352 T1349 prep of,number
R894 T1353 T1354 amod additional,loci
R895 T1354 T1352 pobj loci,of
R896 T1355 T1323 punct .,are
R897 T1357 T1358 nsubj This,raises
R898 T1359 T1360 det the,possibility
R899 T1360 T1358 dobj possibility,raises
R900 T1361 T1362 mark that,be
R901 T1362 T1360 acl be,possibility
R902 T1363 T1362 nsubj some,be
R903 T1364 T1363 cc or,some
R904 T1365 T1366 advmod even,all
R905 T1366 T1363 conj all,some
R906 T1367 T1363 prep of,some
R907 T1368 T1369 det the,defect
R908 T1369 T1367 pobj defect,of
R909 T1370 T1369 amod recombinational,defect
R910 T1371 T1369 compound repair,defect
R911 T1372 T1369 acl seen,defect
R912 T1373 T1372 prep in,seen
R913 T1374 T1373 pobj CAPAN,in
R914 T1375 T1374 punct -,CAPAN
R915 T1376 T1374 nummod 1,CAPAN
R916 T1377 T1362 aux could,be
R917 T1378 T1362 prep due,be
R918 T1379 T1378 pcomp to,due
R919 T1380 T1378 pobj mutations,due
R920 T1381 T1380 prep at,mutations
R921 T1382 T1383 amod non-BRCA2,loci
R922 T1383 T1381 pobj loci,at
R923 T1384 T1358 punct .,raises